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Myocardial infarction in young people with normal coronary arteries | Heart
<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE html> <html lang="en" dir="ltr" version="HTML+RDFa+MathML 1.1" xmlns:dc="http://purl.org/dc/terms/" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:og="http://ogp.me/ns#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#" xmlns:sioct="http://rdfs.org/sioc/types#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head profile="http://www.w3.org/1999/xhtml/vocab"> <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//securepubads.g.doubleclick.net" /> <link rel="dns-prefetch" href="//d1bxh8uas1mnw7.cloudfront.net" /> <link rel="dns-prefetch" href="//scholar.google.com" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="shortcut icon" href="https://heart.bmj.com/sites/default/themes/bmjj/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <script>window.dataLayer = window.dataLayer || [];window.dataLayer.push({"page":{"hwTitle":"Myocardial infarction in young people with normal coronary arteries","hwUrl":"https://heart.bmj.com/content/79/2/191","hwPath":"/content/79/2/191.long","hwType":"journal page"},"user":{"hwMemberID":"","hwLoggedIntoInstitutionID":"","hwLoggedIntoInstitution":"","hwAccessUsageTerms":"guest","hwRegisteredUser":"no","hwHasFullTextAccess":"no","hwEntitled":"no","mail":"e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855"},"content":{"hwIssueDate":"1998-02-01","hwIssueDateTime":"1998-02-01 00:00:00","hwPublicationDate":"2022-01-10","hwPublicationDateTime":"2022-01-10 07:43:15","hwNlmArticleType":"other","hwDOI":"10.1136/hrt.79.2.191","hwAuthors":"M J A Williams,N J Restieaux,C J S Low","hwContributors":"","hwIsEarlyRelease":"no","hwEissn":"1468-201X","hwPissn":"1355-6037","hwVolume":"79","hwIssue":"2","hwArticleType":"Case studies","hwTabView":"main_tab","hwViewType":"long","hwAccessType":"Paywall","hwOpenAccess":"no","hwFreeAccess":"no","hwTaxonomy":"Drugs: cardiovascular system|Acute coronary syndromes|Clinical diagnostic tests|Interventional cardiology|Tobacco use","hwCorpusCode":"heartjnl","hwType":"article","hwSubtitle":null,"hwOverline":null,"hwPisaId":"heartjnl;79/2/191","hwFirstPage":"191","hwLastPage":"194","hwIsLatestVersion":"yes","hwIsCurrentIssue":"no","hwIsOpenIssue":"no","hwHasFullText":"yes","hwHasPDF":"yes","hwParentTitle":"Heart: 79 (2)","hwElectronicPubDate":"2022-01-10","hwElectronicPubDateTime":"2022-01-10 07:43:15"}}); //--><!]]></script> <link rel="canonical" href="https://heart.bmj.com/content/79/2/191" /> <meta name="Generator" content="Drupal 7 (http://drupal.org)" /> <link rel="alternate" type="application/pdf" title="Full Text (PDF)" href="/content/79/2/191.full.pdf" /> <link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/79/2/191.full.txt" /> <meta name="type" content="article" /> <meta name="category" content="other" /> <meta name="HW.identifier" content="/heartjnl/79/2/191.atom" /> <meta name="HW.pisa" content="heartjnl;79/2/191" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta name="DC.Title" content="Myocardial infarction in young people with normal coronary arteries" /> <meta name="DC.Identifier" content="10.1136/hrt.79.2.191" /> <meta name="DC.Date" content="1998-02-01" /> <meta name="DC.Publisher" content="BMJ Publishing Group Ltd and British Cardiovascular Society" /> <meta name="DC.Rights" content="British Cardiac Society" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Myocardial infarction occurring in young people with angiographically normal coronary arteries is well described but the pathophysiology of this condition remains unknown. Coronary artery spasm in association with thrombus formation and minimal atheromatous disease or spontaneous coronary artery dissection are possible causes. Two young men presented with severe chest pain after acute alcohol intoxication and each sustained an extensive anterior myocardial infarction. Investigations including intravascular ultrasound showed no evidence of atherosclerotic coronary artery disease. Coronary artery spasm associated with acute alcohol intoxication as well as a prothrombotic state and endothelial damage related to cigarette smoking may be mechanisms leading to acute myocardial infarction in these cases. Acute myocardial infarction occurs in young persons with normal coronary arteries and the diagnosis should be considered in young patients presenting with severe chest pain, particularly those abusing cocaine or alcohol, so that reperfusion therapy can be initiated promptly." /> <meta name="DC.Contributor" content="M J A Williams" /> <meta name="DC.Contributor" content="N J Restieaux" /> <meta name="DC.Contributor" content="C J S Low" /> <meta name="article:published_time" content="1998-02-01" /> <meta name="article:section" content="Case studies" /> <meta name="citation_title" content="Myocardial infarction in young people with normal coronary arteries" /> <meta name="citation_abstract" lang="en" content="<p>Myocardial infarction occurring in young people with angiographically normal coronary arteries is well described but the pathophysiology of this condition remains unknown. Coronary artery spasm in association with thrombus formation and minimal atheromatous disease or spontaneous coronary artery dissection are possible causes. Two young men presented with severe chest pain after acute alcohol intoxication and each sustained an extensive anterior myocardial infarction. Investigations including intravascular ultrasound showed no evidence of atherosclerotic coronary artery disease. Coronary artery spasm associated with acute alcohol intoxication as well as a prothrombotic state and endothelial damage related to cigarette smoking may be mechanisms leading to acute myocardial infarction in these cases. Acute myocardial infarction occurs in young persons with normal coronary arteries and the diagnosis should be considered in young patients presenting with severe chest pain, particularly those abusing cocaine or alcohol, so that reperfusion therapy can be initiated promptly.</p>" /> <meta name="citation_journal_title" content="Heart" /> <meta name="citation_publisher" content="BMJ Publishing Group Ltd and British Cardiovascular Society" /> <meta name="citation_publication_date" content="1998/02/01" /> <meta name="citation_mjid" content="heartjnl;79/2/191" /> <meta name="citation_id" content="79/2/191" /> <meta name="citation_public_url" content="https://heart.bmj.com/content/79/2/191" /> <meta name="citation_abstract_html_url" content="https://heart.bmj.com/content/79/2/191.abstract" /> <meta name="citation_full_html_url" content="https://heart.bmj.com/content/79/2/191.full" /> <meta name="citation_pdf_url" content="https://heart.bmj.com/content/heartjnl/79/2/191.full.pdf" /> <meta name="citation_issn" content="1355-6037" /> <meta name="citation_issn" content="1468-201X" /> <meta name="citation_journal_abbrev" content="Heart" /> <meta name="citation_doi" content="10.1136/hrt.79.2.191" /> <meta name="citation_pmid" content="9538315" /> <meta name="citation_volume" content="79" /> <meta name="citation_issue" content="2" /> <meta name="citation_article_type" content="Other" /> <meta name="citation_section" content="Case studies" /> <meta name="citation_firstpage" content="191" /> <meta name="citation_lastpage" content="194" /> <meta name="citation_author" content="M J A Williams" /> <meta name="citation_author_institution" content="Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand" /> <meta name="citation_author" content="N J Restieaux" /> <meta name="citation_author_institution" content="Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand" /> <meta name="citation_author" content="C J S Low" /> <meta name="citation_author_institution" content="Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand" /> <meta name="citation_reference" content="citation_journal_title=Circulation;citation_journal_abbrev=Circulation;citation_author=EN. 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Zimmerman;citation_author=RB. Chesne;citation_title=Transmural myocardial infarction with normal coronary angiograms and with single vessel coronary obstruction. Clinical-angiographic features and five-year follow-up;citation_pages=196-202;citation_volume=83;citation_year=1983;citation_issue=2;citation_pmid=6822101;citation_doi=10.1378/chest.83.2.196" /> <meta name="twitter:title" content="Myocardial infarction in young people with normal coronary arteries" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://heart.bmj.com/sites/default/files/highwire/heartjnl/110/24.cover-source.jpg" /> <meta name="twitter:description" content="Myocardial infarction occurring in young people with angiographically normal coronary arteries is well described but the pathophysiology of this condition remains unknown. Coronary artery spasm in association with thrombus formation and minimal atheromatous disease or spontaneous coronary artery dissection are possible causes. Two young men presented with severe chest pain after acute alcohol intoxication and each sustained an extensive anterior myocardial infarction. Investigations including intravascular ultrasound showed no evidence of atherosclerotic coronary artery disease. Coronary artery spasm associated with acute alcohol intoxication as well as a prothrombotic state and endothelial damage related to cigarette smoking may be mechanisms leading to acute myocardial infarction in these cases. Acute myocardial infarction occurs in young persons with normal coronary arteries and the diagnosis should be considered in young patients presenting with severe chest pain, particularly those abusing cocaine or alcohol, so that reperfusion therapy can be initiated promptly." /> <meta name="og-title" property="og:title" content="Myocardial infarction in young people with normal coronary arteries" /> <meta name="og-url" property="og:url" content="https://heart.bmj.com/content/79/2/191" /> <meta name="og-site-name" property="og:site_name" content="Heart" /> <meta name="og-description" property="og:description" content="Myocardial infarction occurring in young people with angiographically normal coronary arteries is well described but the pathophysiology of this condition remains unknown. Coronary artery spasm in association with thrombus formation and minimal atheromatous disease or spontaneous coronary artery dissection are possible causes. Two young men presented with severe chest pain after acute alcohol intoxication and each sustained an extensive anterior myocardial infarction. Investigations including intravascular ultrasound showed no evidence of atherosclerotic coronary artery disease. Coronary artery spasm associated with acute alcohol intoxication as well as a prothrombotic state and endothelial damage related to cigarette smoking may be mechanisms leading to acute myocardial infarction in these cases. Acute myocardial infarction occurs in young persons with normal coronary arteries and the diagnosis should be considered in young patients presenting with severe chest pain, particularly those abusing cocaine or alcohol, so that reperfusion therapy can be initiated promptly." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://heart.bmj.com/sites/default/files/highwire/heartjnl/110/24.cover-source.jpg" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/79/2/191.ppt" /> <title>Myocardial infarction in young people with normal coronary arteries | Heart</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__SXL3_xTfe3XXkpNm43dxA2uKsQDjz2dOHmEpDZd_f2I__xUSLd2Ma72V6TZnlis3CmKtirol7SI-M3tHOtq4-H9M__p6CULtR_D--lY2Qlb2CJ_GXKtVXWfKdESVzHVsOQIcg.css" media="all" /> <!-- OneTrust Cookies Consent Notice start --> <script 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highwire-cite-highwire-article highwire-citation-bmjj-title clearfix"> <div class="highwire-cite-title">Myocardial infarction in young people with normal coronary arteries</div> <span class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="heartjnl;79/2/191" data-atom-uri="/heartjnl/79/2/191.atom" data-request-view="full"></span></span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs-container col-narrow-12 clear" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_template_bmjj_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://heart.bmj.com/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_template_bmjj_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">M J A Williams</span>, </li><li class="contributor" id="contrib-2"><span class="name">N J Restieaux</span>, </li><li class="last" id="contrib-3"><span class="name">C J S Low</span></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address>Department of Medicine, University of Otago, 201 Great King Street, Dunedin, New Zealand</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Dr Williams email: <span class="em-link"><span class="em-addr">michael.williams{at}stonebow.otago.ac.nz</span></span> </li></ol></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup abstract-with-bc" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-1">Myocardial infarction occurring in young people with angiographically normal coronary arteries is well described but the pathophysiology of this condition remains unknown. Coronary artery spasm in association with thrombus formation and minimal atheromatous disease or spontaneous coronary artery dissection are possible causes. Two young men presented with severe chest pain after acute alcohol intoxication and each sustained an extensive anterior myocardial infarction. Investigations including intravascular ultrasound showed no evidence of atherosclerotic coronary artery disease. Coronary artery spasm associated with acute alcohol intoxication as well as a prothrombotic state and endothelial damage related to cigarette smoking may be mechanisms leading to acute myocardial infarction in these cases. Acute myocardial infarction occurs in young persons with normal coronary arteries and the diagnosis should be considered in young patients presenting with severe chest pain, particularly those abusing cocaine or alcohol, so that reperfusion therapy can be initiated promptly.</p></div><ul class="kwd-group"><li class="kwd">myocardial infarction</li><li class="kwd">coronary vasospasm</li><li class="kwd">alcohol</li><li class="kwd">intravascular ultrasound</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right" > <div class="pane-content"> <div id="dfp-ad-mpu-wrapper" class="dfp-tag-wrapper"> <div id="dfp-ad-mpu" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-mpu"); }); </script> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-1" > <div class="pane-content"> <p><a href="https://doi.org/10.1136/hrt.79.2.191" target="_new">https://doi.org/10.1136/hrt.79.2.191</a></p> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-altmetrics" > <h2 class="pane-title">Statistics from Altmetric.com</h2> <div class="pane-content"> <div data-badge-details="right" data-badge-type="medium-donut" data-doi="10.1136/hrt.79.2.191" data-hide-no-mentions="true" class="altmetric-embed"></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-bmjj-jumplinks" > <div class="pane-content"> <div class="highwire-list-wrapper"><div class="highwire-list"><ul></ul></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-2 permissions-box" > <h2 class="pane-title">Request Permissions</h2> <div class="pane-content"> <p>If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. 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