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It is peculiar in that it is not a circumscribed disease. It is a scourge both in developed and developing countries as it has been recognised as one of the greatest causes of perinatal mortality. In 2005, it was estimated that about 1.6 million neonatal deaths in developing countries were caused by neonatal infections[1]. In these countries, neonatal infections were found to cause 34 out of 1000 deaths compared to 5 out of 1000 neonatal deaths in developed countries[2]. It was found to be the sixth greatest cause of death neonates in the United States in 2011[3]. Among major causes of neonatal death are perinatal asphyxia and prematurity[1]. Despite decades of history on the subject, a definition has yet to be established for neonatal sepsis. Over the years, the definition has included the isolation of a causative microorganism (bacteria, fungi, virus) from clinical samples obtained from the baby. Loosely, it is a term used to designate a systemic condition of bacterial, viral, or fungal (yeast) origin that is associated with haemodynamic changes and other clinical manifestations and results in substantial morbidity and mortality[4]. In 2005, the International Paediatric Sepsis Consensus Conference defined sepsis as a “systemic inflammatory response syndrome (SIRS) in the presence of or as a result of suspected or proven 5infection.”[5] New born infants are predisposed to infections which lead to sepsis and the reason for this is discernible in the nature of their immune systems. The immune system of the new born is greatly devoid of several components and those which are present are largely underdeveloped[3]. This state leaves them susceptible/vulnerable to infections by a host of organisms which range from viruses, fungi, bacteria et cetera[3].","author":[{"@context":"https://schema.org","@type":"Person","name":"Ifemed Journal"},{"@context":"https://schema.org","@type":"Person","name":"E. Adejuyigbe"}],"contributor":[{"@context":"https://schema.org","@type":"Person","name":"E. Adejuyigbe"}],"dateCreated":"2020-02-19","dateModified":"2024-11-30","datePublished":null,"headline":"Neonatal Sepsis: Current Issues","inLanguage":"en","keywords":["Neonatal Sepsis"],"locationCreated":null,"publication":null,"publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/42015561/Neonatal_Sepsis_Current_Issues","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" 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window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":42015561,"created_at":"2020-02-19T04:32:21.414-08:00","from_world_paper_id":null,"updated_at":"2024-11-30T11:21:26.611-08:00","_data":{"abstract":"Neonatal sepsis is an entity of worldwide concern. It is peculiar in that it is not a circumscribed disease. It is a scourge both in developed and developing countries as it has been recognised as one of the greatest causes of perinatal mortality. In 2005, it was estimated that about 1.6 million neonatal deaths in developing countries were caused by neonatal infections[1]. In these countries, neonatal infections were found to cause 34 out of 1000 deaths compared to 5 out of 1000 neonatal deaths in developed countries[2]. It was found to be the sixth greatest cause of death neonates in the United States in 2011[3]. Among major causes of neonatal death are perinatal asphyxia and prematurity[1].\nDespite decades of history on the subject, a definition has yet to be established for neonatal sepsis. Over the years, the definition has included the isolation of a causative microorganism (bacteria, fungi, virus) from clinical samples obtained from the baby. Loosely, it is a term used to designate a systemic condition of bacterial, viral, or fungal (yeast) origin that is associated with haemodynamic changes and other clinical manifestations and results in substantial morbidity and mortality[4]. In 2005, the International Paediatric Sepsis Consensus Conference defined sepsis as a “systemic inflammatory response syndrome (SIRS) in the presence of or as a result of suspected or proven 5infection.”[5]\nNew born infants are predisposed to infections which lead to sepsis and the reason for this is discernible in the nature of their immune systems. The immune system of the new born is greatly devoid of several components and those which are present are largely underdeveloped[3]. This state leaves them susceptible/vulnerable to infections by a host of organisms which range from viruses, fungi, bacteria et cetera[3].","ai_title_tag":"Neonatal Sepsis: Global Impact and Definition Challenges"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Neonatal Sepsis: Current Issues","broadcastable":true,"draft":false,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [146695012,47625572]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":62140081,"attachmentType":"pdf"}"><img alt="First page of “Neonatal Sepsis: Current Issues”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/62140081/mini_magick20200219-19496-18g35gj.png?1582115567" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Neonatal Sepsis: Current Issues</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="146695012" href="https://independent.academia.edu/EAdejuyigbe"><img alt="Profile image of E. Adejuyigbe" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />E. Adejuyigbe</a><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="47625572" href="https://independent.academia.edu/IfemedJournal"><img alt="Profile image of Ifemed Journal" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/47625572/28112767/26338418/s65_ifemed.journal.jpg" />Ifemed Journal</a></div><div class="ds-work-card--detail"></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Neonatal sepsis is an entity of worldwide concern. It is peculiar in that it is not a circumscribed disease. It is a scourge both in developed and developing countries as it has been recognised as one of the greatest causes of perinatal mortality. In 2005, it was estimated that about 1.6 million neonatal deaths in developing countries were caused by neonatal infections[1]. In these countries, neonatal infections were found to cause 34 out of 1000 deaths compared to 5 out of 1000 neonatal deaths in developed countries[2]. It was found to be the sixth greatest cause of death neonates in the United States in 2011[3]. Among major causes of neonatal death are perinatal asphyxia and prematurity[1]. Despite decades of history on the subject, a definition has yet to be established for neonatal sepsis. Over the years, the definition has included the isolation of a causative microorganism (bacteria, fungi, virus) from clinical samples obtained from the baby. Loosely, it is a term used to designate a systemic condition of bacterial, viral, or fungal (yeast) origin that is associated with haemodynamic changes and other clinical manifestations and results in substantial morbidity and mortality[4]. In 2005, the International Paediatric Sepsis Consensus Conference defined sepsis as a “systemic inflammatory response syndrome (SIRS) in the presence of or as a result of suspected or proven 5infection.”[5] New born infants are predisposed to infections which lead to sepsis and the reason for this is discernible in the nature of their immune systems. The immune system of the new born is greatly devoid of several components and those which are present are largely underdeveloped[3]. This state leaves them susceptible/vulnerable to infections by a host of organisms which range from viruses, fungi, bacteria et cetera[3].</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":62140081,"attachmentType":"pdf","workUrl":"https://www.academia.edu/42015561/Neonatal_Sepsis_Current_Issues"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":62140081,"attachmentType":"pdf","workUrl":"https://www.academia.edu/42015561/Neonatal_Sepsis_Current_Issues"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="62140081" data-landing_url="https://www.academia.edu/42015561/Neonatal_Sepsis_Current_Issues" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="54957757" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54957757/Neonatal_Sepsis_Past_to_Present">Neonatal Sepsis Past to Present</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26200429" href="https://independent.academia.edu/SantoshKumarKamalakannan">Santosh Kumar Kamalakannan</a></div><p 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