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100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Saleem Basha S</h3></div><div class="js-work-strip profile--work_container" data-work-id="112651215"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112651215/Reduced_Th17_responses_to_Streptococcus_pneumoniae_in_infection_prone_children_can_be_rescued_by_addition_of_innate_cytokines"><img alt="Research paper thumbnail of Reduced Th17 responses to Streptococcus pneumoniae in infection-prone children can be rescued by addition of innate cytokines" class="work-thumbnail" src="https://attachments.academia-assets.com/109815517/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112651215/Reduced_Th17_responses_to_Streptococcus_pneumoniae_in_infection_prone_children_can_be_rescued_by_addition_of_innate_cytokines">Reduced Th17 responses to Streptococcus pneumoniae in infection-prone children can be rescued by addition of innate cytokines</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Apr 13, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understand the mechanism of failure of Th17 immunity resulting in Spn infections in children less than 2 years old. Peripheral blood mononuclear cells (PBMCs) from infection-prone (IP) and non-infection-prone (NIP) children of 9-18 months old were examined for their responses to heat-killed Spn by flow cytometry, RT-PCR, and ELISA. We measured cytokine production, proliferation and differentiation of Th17 cells and the expression of transcription factors in response to Spn. PBMCs of IP children stimulated with heat-killed Spn had significantly reduced percentages of CD4+ Th1 (interleukin (IL)-2, TNF-α) and Th17 (IL-17A) cells compared to NIP children. Addition of exogenous Th17-promoting cytokines (IL-6, IL-1β, IL-23 and TGF-β) restored CD4+ Th17 cell function in cells from IP children to levels measured in NIP children. Reduced Th17 responses to Spn in PBMCs of IP children can be rescued by addi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="989b989e25b750d9d247781af5176a6e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815517,"asset_id":112651215,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815517/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112651215"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112651215"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112651215; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112651215]").text(description); $(".js-view-count[data-work-id=112651215]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112651215; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112651215']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112651215, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "989b989e25b750d9d247781af5176a6e" } } $('.js-work-strip[data-work-id=112651215]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112651215,"title":"Reduced Th17 responses to Streptococcus pneumoniae in infection-prone children can be rescued by addition of innate cytokines","translated_title":"","metadata":{"abstract":"Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understand the mechanism of failure of Th17 immunity resulting in Spn infections in children less than 2 years old. Peripheral blood mononuclear cells (PBMCs) from infection-prone (IP) and non-infection-prone (NIP) children of 9-18 months old were examined for their responses to heat-killed Spn by flow cytometry, RT-PCR, and ELISA. We measured cytokine production, proliferation and differentiation of Th17 cells and the expression of transcription factors in response to Spn. PBMCs of IP children stimulated with heat-killed Spn had significantly reduced percentages of CD4+ Th1 (interleukin (IL)-2, TNF-α) and Th17 (IL-17A) cells compared to NIP children. Addition of exogenous Th17-promoting cytokines (IL-6, IL-1β, IL-23 and TGF-β) restored CD4+ Th17 cell function in cells from IP children to levels measured in NIP children. 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Email: {1amudhavel86, 1smartsaleem1979, 1vengat.mailbox, 1dhavachelvan, 2baskaran. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112651213"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112651213"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112651213; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112651213]").text(description); $(".js-view-count[data-work-id=112651213]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112651213; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112651213']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112651213, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112651213]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112651213,"title":"Metric based Efficient Traffic Management in Intranets using Incremental Advanced DST Approach","translated_title":"","metadata":{"abstract":"1Department of Computer Science, Pondicherry University, Puducherry, India. 2Department of Computer Science and Engineering, Anna University, Chennai, India. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650769"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650769/Domain_specific_variation_in_hemagglutinin_specific_T_cell_responses_elicited_by_licensed_seasonal_influenza_vaccines_106_11_"><img alt="Research paper thumbnail of Domain-specific variation in hemagglutinin-specific T-cell responses elicited by licensed seasonal influenza vaccines (106.11)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650769/Domain_specific_variation_in_hemagglutinin_specific_T_cell_responses_elicited_by_licensed_seasonal_influenza_vaccines_106_11_">Domain-specific variation in hemagglutinin-specific T-cell responses elicited by licensed seasonal influenza vaccines (106.11)</a></div><div class="wp-workCard_item"><span>Journal of Immunology</span><span>, Apr 1, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650769]").text(description); $(".js-view-count[data-work-id=112650769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650769, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650768"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650768/Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_"><img alt="Research paper thumbnail of Human T cell immunity to influenza: magnitude, breadth, and antigenic variation (130.17)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650768/Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_">Human T cell immunity to influenza: magnitude, breadth, and antigenic variation (130.17)</a></div><div class="wp-workCard_item"><span>The Journal of Immunology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Unraveling the nature of T cell immunity to influenza is currently an active area of research. Se...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Unraveling the nature of T cell immunity to influenza is currently an active area of research. Several lines of evidence now suggest that cell mediated immunity plays a significant role in controlling influenza disease in humans. While influenza hemagglutinin (HA)-specific humoral responses have been studied in considerable detail, our understanding of the coexistent cellular responses elicited by HA in humans is woefully limited. Utilizing quantitative approaches including ELISPOT and multiparametric flow cytometry we determine the magnitude of cell mediated responses to HA, the lineage of the responding T cells, and their frequency of prevalence in a tightly-defined cohort of healthy subjects. We demonstrate that the magnitude of HA-specific T cell memory populations are maintained at a low, finite frequency and vary significantly among individuals. HA-specific humoral- and T cell immunity do not correlate with each other. Importantly, the contribution of the T cell responses elic...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650768"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650768; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650768]").text(description); $(".js-view-count[data-work-id=112650768]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650768; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650768']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650768, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650768]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650768,"title":"Human T cell immunity to influenza: magnitude, breadth, and antigenic variation (130.17)","translated_title":"","metadata":{"abstract":"Unraveling the nature of T cell immunity to influenza is currently an active area of research. Several lines of evidence now suggest that cell mediated immunity plays a significant role in controlling influenza disease in humans. While influenza hemagglutinin (HA)-specific humoral responses have been studied in considerable detail, our understanding of the coexistent cellular responses elicited by HA in humans is woefully limited. Utilizing quantitative approaches including ELISPOT and multiparametric flow cytometry we determine the magnitude of cell mediated responses to HA, the lineage of the responding T cells, and their frequency of prevalence in a tightly-defined cohort of healthy subjects. We demonstrate that the magnitude of HA-specific T cell memory populations are maintained at a low, finite frequency and vary significantly among individuals. HA-specific humoral- and T cell immunity do not correlate with each other. Importantly, the contribution of the T cell responses elic...","publisher":"The American Association of Immunologists","publication_name":"The Journal of Immunology"},"translated_abstract":"Unraveling the nature of T cell immunity to influenza is currently an active area of research. Several lines of evidence now suggest that cell mediated immunity plays a significant role in controlling influenza disease in humans. While influenza hemagglutinin (HA)-specific humoral responses have been studied in considerable detail, our understanding of the coexistent cellular responses elicited by HA in humans is woefully limited. Utilizing quantitative approaches including ELISPOT and multiparametric flow cytometry we determine the magnitude of cell mediated responses to HA, the lineage of the responding T cells, and their frequency of prevalence in a tightly-defined cohort of healthy subjects. We demonstrate that the magnitude of HA-specific T cell memory populations are maintained at a low, finite frequency and vary significantly among individuals. HA-specific humoral- and T cell immunity do not correlate with each other. Importantly, the contribution of the T cell responses elic...","internal_url":"https://www.academia.edu/112650768/Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_","translated_internal_url":"","created_at":"2023-12-30T23:06:26.045-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":18327,"name":"Immunology of the Gut","url":"https://www.academia.edu/Documents/in/Immunology_of_the_Gut"},{"id":84924,"name":"Immunity","url":"https://www.academia.edu/Documents/in/Immunity"},{"id":2019324,"name":"Humoral Immunity","url":"https://www.academia.edu/Documents/in/Humoral_Immunity"}],"urls":[{"id":37987720,"url":"https://journals.aai.org/jimmunol/article/182/1_Supplement/130.17/44822/Human-T-cell-immunity-to-influenza-magnitude"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650767"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center"><img alt="Research paper thumbnail of Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center">Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center</a></div><div class="wp-workCard_item"><span>Indian Journal of Surgical Oncology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The oncological necessity of submandibular gland removal during neck dissection for oral cavity s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650767"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650767"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650767; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650767]").text(description); $(".js-view-count[data-work-id=112650767]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650767; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650767']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650767, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650767]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650767,"title":"Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center","translated_title":"","metadata":{"abstract":"The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...","publisher":"Indian Journal of Surgical Oncology","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Indian Journal of Surgical Oncology"},"translated_abstract":"The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...","internal_url":"https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center","translated_internal_url":"","created_at":"2023-12-30T23:06:25.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":15052,"name":"Surgical Oncology","url":"https://www.academia.edu/Documents/in/Surgical_Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":2717351,"name":"Prospective Cohort Study","url":"https://www.academia.edu/Documents/in/Prospective_Cohort_Study"},{"id":3194190,"name":"Neck dissection","url":"https://www.academia.edu/Documents/in/Neck_dissection"},{"id":3768034,"name":"Perineural invasion","url":"https://www.academia.edu/Documents/in/Perineural_invasion"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650766"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services"><img alt="Research paper thumbnail of Analysis on Countering XML-Based Attacks in Web Services" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services">Analysis on Countering XML-Based Attacks in Web Services</a></div><div class="wp-workCard_item"><span>International Review on Computers and Software</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) imp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650766]").text(description); $(".js-view-count[data-work-id=112650766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650766, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650766,"title":"Analysis on Countering XML-Based Attacks in Web Services","translated_title":"","metadata":{"abstract":"Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"International Review on Computers and Software"},"translated_abstract":"Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.","internal_url":"https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services","translated_internal_url":"","created_at":"2023-12-30T23:06:25.767-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Analysis_on_Countering_XML_Based_Attacks_in_Web_Services","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":5279,"name":"XML","url":"https://www.academia.edu/Documents/in/XML"},{"id":13923,"name":"Computer Security","url":"https://www.academia.edu/Documents/in/Computer_Security"},{"id":26860,"name":"Cloud Computing","url":"https://www.academia.edu/Documents/in/Cloud_Computing"},{"id":316280,"name":"SOAP","url":"https://www.academia.edu/Documents/in/SOAP"},{"id":317992,"name":"Web Service","url":"https://www.academia.edu/Documents/in/Web_Service"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650765/Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants"><img alt="Research paper thumbnail of Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants" class="work-thumbnail" src="https://attachments.academia-assets.com/109815184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650765/Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants">Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Jun 9, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated"> We sought to understand why some children respond poorly to vaccinations in the first year of li...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden"> We sought to understand why some children respond poorly to vaccinations in the first year of life. A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell (PBMC) samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed by ELISA, and frequency of memory B-cells, functional T-cell responses, and APC responses were assessed in PBMC samples by flow cytometric analysis. 11% of children were low vaccine responders (LVRs) defined a priori as those with sub-protective IgG antibody levels to ≥66% of vaccines tested. LVRs generated fewer memory B-cells, had reduced activation by CD4+ and CD8+ T-cells upon polyclonal stimulation, and displayed lower MHC II expression by APCs. We conclude that sub-protective vaccine responses in infants are associated with a distinct immunologic profile.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a707a71816b7d2f78255e1f8621550fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815184,"asset_id":112650765,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815184/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650765]").text(description); $(".js-view-count[data-work-id=112650765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a707a71816b7d2f78255e1f8621550fe" } } $('.js-work-strip[data-work-id=112650765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650765,"title":"Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants","translated_title":"","metadata":{"abstract":" We sought to understand why some children respond poorly to vaccinations in the first year of life. 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We conclude that sub-protective vaccine responses in infants are associated with a distinct immunologic profile.","publication_date":{"day":9,"month":6,"year":2016,"errors":{}},"publication_name":"The Journal of infectious diseases"},"translated_abstract":" We sought to understand why some children respond poorly to vaccinations in the first year of life. A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell (PBMC) samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed by ELISA, and frequency of memory B-cells, functional T-cell responses, and APC responses were assessed in PBMC samples by flow cytometric analysis. 11% of children were low vaccine responders (LVRs) defined a priori as those with sub-protective IgG antibody levels to ≥66% of vaccines tested. LVRs generated fewer memory B-cells, had reduced activation by CD4+ and CD8+ T-cells upon polyclonal stimulation, and displayed lower MHC II expression by APCs. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650764"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650764/Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae"><img alt="Research paper thumbnail of Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650764/Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae">Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae</a></div><div class="wp-workCard_item"><span>Expert review of vaccines</span><span>, Jul 19, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory naso...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650764"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650764"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650764; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650764]").text(description); $(".js-view-count[data-work-id=112650764]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650764; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650764']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650764, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650764]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650764,"title":"Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae","translated_title":"","metadata":{"abstract":"Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.","publication_date":{"day":19,"month":7,"year":2016,"errors":{}},"publication_name":"Expert review of vaccines"},"translated_abstract":"Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. 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Gelatin and sodium alginate have proven to own wound healing properties individually. Hence the combination of these two polymers and incorporation of drugs into their matrices may show a synergistic improvement in wound healing activity. Hence, the objective of this study was to evaluate the efficacy of sustained release of aminoglycoside antibiotic gentamycin from gelatin-alginate matrix, in order to establish a new delivery system for local anti-infective therapy. Thus, the drug loaded Gelatin-alginate matrices were prepared with two different gelatin concentrations (3% and 5%) and evaluated for various in vitro evaluation tests like swelling capacity, drug loading efficiency, SEM, FT-IR, in-vitro drug release by diffusion studies, antibacterial activity, and wound healing studies. The obtained matrices were characterized by good sorption properties and int...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd6b572b4777a518bdbca85669e63f16" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109998671,"asset_id":112650761,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109998671/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650761"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650761"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650761; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650761]").text(description); $(".js-view-count[data-work-id=112650761]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650761; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650761']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650761, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fd6b572b4777a518bdbca85669e63f16" } } $('.js-work-strip[data-work-id=112650761]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650761,"title":"Design and evaluation of controlled release gentamycin incorporated gelatin alginate matrices for wound management","translated_title":"","metadata":{"abstract":"Natural polymers have gained profound importance as lead compounds for delivery of drugs in treatment of various infections. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650760"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650760/A_Context_Driven_Multidimensional_Matching_Model_For_Information_Retrieval"><img alt="Research paper thumbnail of A Context-Driven Multidimensional Matching Model For Information Retrieval" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650760/A_Context_Driven_Multidimensional_Matching_Model_For_Information_Retrieval">A Context-Driven Multidimensional Matching Model For Information Retrieval</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Current information retrieval systems face three inherent limitations. To overcome these deficien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Current information retrieval systems face three inherent limitations. To overcome these deficiencies, a multidimensional match model was proposed to use context as an independent dimension besides content dimension. All contexts were classified into two parts: context about users and context about documents. The Discounted Cumulative Gain was introduced to evaluate the search results. Results showed that this model can improve the relevance of returned items, and also demonstrated that the implicit match owns more weight than explicit match</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650760"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650760"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650760; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650760]").text(description); $(".js-view-count[data-work-id=112650760]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650760; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650760']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650760, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650760]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650760,"title":"A Context-Driven Multidimensional Matching Model For Information Retrieval","translated_title":"","metadata":{"abstract":"Current information retrieval systems face three inherent limitations. 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650759]").text(description); $(".js-view-count[data-work-id=112650759]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650759; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650759']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650759, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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It causes symmetric polyarthritis involving smaller and larger joints and extra-articular manifestations. Rheumatoid arthritis is associated with increased cardiovascular events including cardiac insufficiency, acute myocardial infarction and stroke. [1] It was said that the release of pro-inflammatory cytokines and acute phase proteins are responsible for atherosclerosis. [2] Cardiovascular disease (CVD) in rheumatoid arthritis patients accounts for 35% to 51% of all mortality. [3] Lipoprotein (a) [Lp (a)] is a low-density lipoprotein (LDL)-like particle, which has apolipoprotein (A) [apo (A)] attached to apolipoprotein (B) [apo (B)] molecule via disulfide bond. There are 34 different Lp (a) isoforms depending on the size of apo (A). Lp (a) levels are influenced by apo (A) polymorphism. [4] Apolipoprotein (A) has a high degree homology with plasminogen and competes with plasminogen for fibrin binding sites and inhibits fibrinolysis. This increases plaque formation and thus promotes atherosclerosis. In addition to its role as a cholesterol carrier, Lp (a) involved in both inflammation and thrombosis. Lp (a) was significantly associated with acute phase proteins and was found to promote proliferation of vascular smooth muscle cells and chemotaxis of human monocytes.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Journal of Pharmacy And Bioallied Sciences","grobid_abstract_attachment_id":110060109},"translated_abstract":null,"internal_url":"https://www.academia.edu/112650759/A_comparative_study_on_serum_lipoprotein_a_and_lipid_profile_between_rheumatoid_arthritis_patients_and_normal_subjects","translated_internal_url":"","created_at":"2023-12-30T23:06:24.681-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":110060109,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110060109/thumbnails/1.jpg","file_name":"0975-7406.15576720240105-1-2gs4ae.pdf","download_url":"https://www.academia.edu/attachments/110060109/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparative_study_on_serum_lipoprotein.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110060109/0975-7406.15576720240105-1-2gs4ae-libre.pdf?1704443718=\u0026response-content-disposition=attachment%3B+filename%3DA_comparative_study_on_serum_lipoprotein.pdf\u0026Expires=1733023617\u0026Signature=fdyaFYOuyH5rovSPTXRHU3LfwBb~WCw~8R1FmEsfMm~SzRq~cDrhS84r8t7pNxRIzK1YS5TE~N9TG5PfmM1yZmWSPosGU9l98Kg9kRUbC7I4Yvk2sbFH2R5F81hRsvswXOF8so4UfSwiBd1EEt7p7-ITOEueZ3~hdoPZvJhvOQt7GloScx0rf2sXZBplVacCm46PkDK60CiQ8M4UYgPob9sukbMzZ9mQU~IyVjZdhx4AMf~LH6~krVk536YuHytjueWQhePlmcDafUTmvhYrpwv3zsZ-vdTbKnzOiYOf-jx3aJclUfm8eD4mTr60Dr1DusUg9uyF8JIOB3b2jVddiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_comparative_study_on_serum_lipoprotein_a_and_lipid_profile_between_rheumatoid_arthritis_patients_and_normal_subjects","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[{"id":110060109,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110060109/thumbnails/1.jpg","file_name":"0975-7406.15576720240105-1-2gs4ae.pdf","download_url":"https://www.academia.edu/attachments/110060109/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparative_study_on_serum_lipoprotein.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110060109/0975-7406.15576720240105-1-2gs4ae-libre.pdf?1704443718=\u0026response-content-disposition=attachment%3B+filename%3DA_comparative_study_on_serum_lipoprotein.pdf\u0026Expires=1733023617\u0026Signature=fdyaFYOuyH5rovSPTXRHU3LfwBb~WCw~8R1FmEsfMm~SzRq~cDrhS84r8t7pNxRIzK1YS5TE~N9TG5PfmM1yZmWSPosGU9l98Kg9kRUbC7I4Yvk2sbFH2R5F81hRsvswXOF8so4UfSwiBd1EEt7p7-ITOEueZ3~hdoPZvJhvOQt7GloScx0rf2sXZBplVacCm46PkDK60CiQ8M4UYgPob9sukbMzZ9mQU~IyVjZdhx4AMf~LH6~krVk536YuHytjueWQhePlmcDafUTmvhYrpwv3zsZ-vdTbKnzOiYOf-jx3aJclUfm8eD4mTr60Dr1DusUg9uyF8JIOB3b2jVddiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12733,"name":"Rheumatoid Arthritis","url":"https://www.academia.edu/Documents/in/Rheumatoid_Arthritis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":191096,"name":"Arthritis","url":"https://www.academia.edu/Documents/in/Arthritis"},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease"},{"id":801998,"name":"Lipid Profile","url":"https://www.academia.edu/Documents/in/Lipid_Profile"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650758/Immune_responses_in_neonates"><img alt="Research paper thumbnail of Immune responses in neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/109815177/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650758/Immune_responses_in_neonates">Immune responses in neonates</a></div><div class="wp-workCard_item"><span>Expert Review of Clinical Immunology</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dcccb7ed281a693ea3cb94b5d733e4a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815177,"asset_id":112650758,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815177/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650758; 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Recent advances in understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of exposure. Studies in neonatal mouse models and human umbilical cord blood cells demonstrate the capability of neonatal immune cells to produce immune responses similar to adults in some aspects but not others. This review focuses mainly on the developmental and functional mechanisms of the human neonatal immune system. In particular, the mechanism of innate and adaptive immunity and the role of neutrophils, antigen presenting cells, differences in subclasses of T lymphocytes (Th1, Th2, Tregs) and B cells are discussed. In addition, we have included the recent developments in neonatal mouse immune system. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650757"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650757/An_Overview_of_Web_Services_Composition_Approaches"><img alt="Research paper thumbnail of An Overview of Web Services Composition Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/109815176/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650757/An_Overview_of_Web_Services_Composition_Approaches">An Overview of Web Services Composition Approaches</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba0624e29f8167e17face7474bd6900b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815176,"asset_id":112650757,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815176/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650757"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650757"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650757; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650756"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650756/Web_Service_Based_Secure_E_Learning_Management_System_EWeMS"><img alt="Research paper thumbnail of Web Service Based Secure E-Learning Management System - EWeMS" class="work-thumbnail" src="https://attachments.academia-assets.com/110060160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650756/Web_Service_Based_Secure_E_Learning_Management_System_EWeMS">Web Service Based Secure E-Learning Management System - EWeMS</a></div><div class="wp-workCard_item"><span>Journal of Convergence Information Technology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f9536faec703d134960a9d32e2ad35d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110060160,"asset_id":112650756,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110060160/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650756"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650756"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650756; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650755"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650755/A_Comparative_Analysis_of_Scheduling_Policies_in_Cloud_Computing_Environment"><img alt="Research paper thumbnail of A Comparative Analysis of Scheduling Policies in Cloud Computing Environment" class="work-thumbnail" src="https://attachments.academia-assets.com/109815175/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650755/A_Comparative_Analysis_of_Scheduling_Policies_in_Cloud_Computing_Environment">A Comparative Analysis of Scheduling Policies in Cloud Computing Environment</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b793e067b5786086758c23f1c4bd459" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815175,"asset_id":112650755,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815175/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650755"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650755"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650755; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650754"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650754/Pandemic_and_seasonal_H1N1_influenza_hemagglutinin_specific_T_cell_responses_elicited_by_seasonal_influenza_vaccination"><img alt="Research paper thumbnail of Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination" class="work-thumbnail" src="https://attachments.academia-assets.com/109815223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650754/Pandemic_and_seasonal_H1N1_influenza_hemagglutinin_specific_T_cell_responses_elicited_by_seasonal_influenza_vaccination">Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9c147c3b274166643c3c64c00dbdf39f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815223,"asset_id":112650754,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815223/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650754"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650754"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650754; 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receptors" class="work-thumbnail" src="https://attachments.academia-assets.com/109815186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650753/Polyvalent_inhibitors_of_anthrax_toxin_that_target_host_receptors">Polyvalent inhibitors of anthrax toxin that target host receptors</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance can emerge naturally, but it can also be engineered intentionally, which is an important consideration in designing therapeutics for bioterrorism agents. Blocking host receptors used by pathogens represents a powerful strategy to overcome this problem, because extensive alterations to the pathogen may be required to enable it to switch to a new receptor that can still support pathogenesis. Here, we demonstrate a facile method for producing potent receptor-directed antitoxins. We used phage display to identify a peptide that binds both anthrax-toxin receptors and attached this peptide to a synthetic scaffold. Polyvalency increased the potency of these peptides by &gt;50,000-fold in vitro and enabled the neutralization of anthrax toxin in vivo . This work demonstrates a receptor-directed anthrax-toxin inhibitor and represents a promising strategy to combat a variety of viral and bacterial...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e408c931aa63868fad8e95df21498ca" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815186,"asset_id":112650753,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815186/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650753"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650753"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650753; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650753]").text(description); $(".js-view-count[data-work-id=112650753]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650753; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650753']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650753, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e408c931aa63868fad8e95df21498ca" } } $('.js-work-strip[data-work-id=112650753]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650753,"title":"Polyvalent inhibitors of anthrax toxin that target host receptors","translated_title":"","metadata":{"abstract":"Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. 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We used phage display to identify a peptide that binds both anthrax-toxin receptors and attached this peptide to a synthetic scaffold. Polyvalency increased the potency of these peptides by \u0026gt;50,000-fold in vitro and enabled the neutralization of anthrax toxin in vivo . 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="18649088" id="papers"><div class="js-work-strip profile--work_container" data-work-id="112651215"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112651215/Reduced_Th17_responses_to_Streptococcus_pneumoniae_in_infection_prone_children_can_be_rescued_by_addition_of_innate_cytokines"><img alt="Research paper thumbnail of Reduced Th17 responses to Streptococcus pneumoniae in infection-prone children can be rescued by addition of innate cytokines" class="work-thumbnail" src="https://attachments.academia-assets.com/109815517/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112651215/Reduced_Th17_responses_to_Streptococcus_pneumoniae_in_infection_prone_children_can_be_rescued_by_addition_of_innate_cytokines">Reduced Th17 responses to Streptococcus pneumoniae in infection-prone children can be rescued by addition of innate cytokines</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Apr 13, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understand the mechanism of failure of Th17 immunity resulting in Spn infections in children less than 2 years old. Peripheral blood mononuclear cells (PBMCs) from infection-prone (IP) and non-infection-prone (NIP) children of 9-18 months old were examined for their responses to heat-killed Spn by flow cytometry, RT-PCR, and ELISA. We measured cytokine production, proliferation and differentiation of Th17 cells and the expression of transcription factors in response to Spn. PBMCs of IP children stimulated with heat-killed Spn had significantly reduced percentages of CD4+ Th1 (interleukin (IL)-2, TNF-α) and Th17 (IL-17A) cells compared to NIP children. Addition of exogenous Th17-promoting cytokines (IL-6, IL-1β, IL-23 and TGF-β) restored CD4+ Th17 cell function in cells from IP children to levels measured in NIP children. 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We sought to understand the mechanism of failure of Th17 immunity resulting in Spn infections in children less than 2 years old. Peripheral blood mononuclear cells (PBMCs) from infection-prone (IP) and non-infection-prone (NIP) children of 9-18 months old were examined for their responses to heat-killed Spn by flow cytometry, RT-PCR, and ELISA. We measured cytokine production, proliferation and differentiation of Th17 cells and the expression of transcription factors in response to Spn. PBMCs of IP children stimulated with heat-killed Spn had significantly reduced percentages of CD4+ Th1 (interleukin (IL)-2, TNF-α) and Th17 (IL-17A) cells compared to NIP children. Addition of exogenous Th17-promoting cytokines (IL-6, IL-1β, IL-23 and TGF-β) restored CD4+ Th17 cell function in cells from IP children to levels measured in NIP children. Reduced Th17 responses to Spn in PBMCs of IP children can be rescued by addi...","publication_date":{"day":13,"month":4,"year":2017,"errors":{}},"publication_name":"The Journal of infectious diseases"},"translated_abstract":"Th17 cells are important in the control of Streptococcus pneumoniae (Spn). We sought to understand the mechanism of failure of Th17 immunity resulting in Spn infections in children less than 2 years old. Peripheral blood mononuclear cells (PBMCs) from infection-prone (IP) and non-infection-prone (NIP) children of 9-18 months old were examined for their responses to heat-killed Spn by flow cytometry, RT-PCR, and ELISA. We measured cytokine production, proliferation and differentiation of Th17 cells and the expression of transcription factors in response to Spn. PBMCs of IP children stimulated with heat-killed Spn had significantly reduced percentages of CD4+ Th1 (interleukin (IL)-2, TNF-α) and Th17 (IL-17A) cells compared to NIP children. Addition of exogenous Th17-promoting cytokines (IL-6, IL-1β, IL-23 and TGF-β) restored CD4+ Th17 cell function in cells from IP children to levels measured in NIP children. 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Total LDH activity was significantly increased in all the study groups (cerebrovascular accident group, Neurological cases group and brain tumor cases) as compared to Control group (non-neurological cases). Moreover the current study also suggest that the isoenzyme subunit ratio H/M was significantly decreased (p\u003c0.001) in all the study groups as compared to non-neurological Control group. 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Se...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Unraveling the nature of T cell immunity to influenza is currently an active area of research. Several lines of evidence now suggest that cell mediated immunity plays a significant role in controlling influenza disease in humans. While influenza hemagglutinin (HA)-specific humoral responses have been studied in considerable detail, our understanding of the coexistent cellular responses elicited by HA in humans is woefully limited. Utilizing quantitative approaches including ELISPOT and multiparametric flow cytometry we determine the magnitude of cell mediated responses to HA, the lineage of the responding T cells, and their frequency of prevalence in a tightly-defined cohort of healthy subjects. 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Importantly, the contribution of the T cell responses elic...","publisher":"The American Association of Immunologists","publication_name":"The Journal of Immunology"},"translated_abstract":"Unraveling the nature of T cell immunity to influenza is currently an active area of research. Several lines of evidence now suggest that cell mediated immunity plays a significant role in controlling influenza disease in humans. While influenza hemagglutinin (HA)-specific humoral responses have been studied in considerable detail, our understanding of the coexistent cellular responses elicited by HA in humans is woefully limited. Utilizing quantitative approaches including ELISPOT and multiparametric flow cytometry we determine the magnitude of cell mediated responses to HA, the lineage of the responding T cells, and their frequency of prevalence in a tightly-defined cohort of healthy subjects. We demonstrate that the magnitude of HA-specific T cell memory populations are maintained at a low, finite frequency and vary significantly among individuals. HA-specific humoral- and T cell immunity do not correlate with each other. Importantly, the contribution of the T cell responses elic...","internal_url":"https://www.academia.edu/112650768/Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_","translated_internal_url":"","created_at":"2023-12-30T23:06:26.045-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Human_T_cell_immunity_to_influenza_magnitude_breadth_and_antigenic_variation_130_17_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":18327,"name":"Immunology of the Gut","url":"https://www.academia.edu/Documents/in/Immunology_of_the_Gut"},{"id":84924,"name":"Immunity","url":"https://www.academia.edu/Documents/in/Immunity"},{"id":2019324,"name":"Humoral Immunity","url":"https://www.academia.edu/Documents/in/Humoral_Immunity"}],"urls":[{"id":37987720,"url":"https://journals.aai.org/jimmunol/article/182/1_Supplement/130.17/44822/Human-T-cell-immunity-to-influenza-magnitude"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650767"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center"><img alt="Research paper thumbnail of Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center">Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center</a></div><div class="wp-workCard_item"><span>Indian Journal of Surgical Oncology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The oncological necessity of submandibular gland removal during neck dissection for oral cavity s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650767"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650767"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650767; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650767]").text(description); $(".js-view-count[data-work-id=112650767]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650767; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650767']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650767, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650767]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650767,"title":"Predictive Factors for Submandibular Gland Involvement in Oral Cavity Squamous Cell Carcinoma—a Prospective Study from a Tertiary Cancer Center","translated_title":"","metadata":{"abstract":"The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...","publisher":"Indian Journal of Surgical Oncology","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Indian Journal of Surgical Oncology"},"translated_abstract":"The oncological necessity of submandibular gland removal during neck dissection for oral cavity squamous cell carcinoma surgery has remained controversial. This study was aimed to determine the rate of SMG involvement and assess the feasibility of submandibular gland (SMG) preservation. We present a prospective study conducted at a tertiary cancer center from June 2017 to May 2019. All patients of oral squamous cell carcinoma who underwent primary surgery with neck dissection were included and analyzed for incidence and predictive factors for incidence of level IB nodal and SMG involvement as per CAP guidelines. A total of 60 patients were inducted in the study, wherein 63 neck dissections were performed including bilateral dissection in three cases. There was involvement of SMG in 6 patients with two cases each in floor of mouth cancer, gingivo-buccal, and alveolar lesions. The SMG was involved by direct contiguous spread from the primary lesion in two cases, extra-capsular extensi...","internal_url":"https://www.academia.edu/112650767/Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center","translated_internal_url":"","created_at":"2023-12-30T23:06:25.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Predictive_Factors_for_Submandibular_Gland_Involvement_in_Oral_Cavity_Squamous_Cell_Carcinoma_a_Prospective_Study_from_a_Tertiary_Cancer_Center","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":15052,"name":"Surgical Oncology","url":"https://www.academia.edu/Documents/in/Surgical_Oncology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":2717351,"name":"Prospective Cohort Study","url":"https://www.academia.edu/Documents/in/Prospective_Cohort_Study"},{"id":3194190,"name":"Neck dissection","url":"https://www.academia.edu/Documents/in/Neck_dissection"},{"id":3768034,"name":"Perineural invasion","url":"https://www.academia.edu/Documents/in/Perineural_invasion"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650766"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services"><img alt="Research paper thumbnail of Analysis on Countering XML-Based Attacks in Web Services" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services">Analysis on Countering XML-Based Attacks in Web Services</a></div><div class="wp-workCard_item"><span>International Review on Computers and Software</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) imp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650766]").text(description); $(".js-view-count[data-work-id=112650766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650766, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650766,"title":"Analysis on Countering XML-Based Attacks in Web Services","translated_title":"","metadata":{"abstract":"Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"International Review on Computers and Software"},"translated_abstract":"Cloud Computing is found to be today’s most commonly used Service Oriented Architecture (SOA) implementation. Cloud utilizes XML-based technologies like Web Services for accessing and controlling the cloud, these are of particular importance for the security assessment of cloud systems. XML usage in Web Service introduces various vulnerabilities which affects basic security factors such as Confidentiality, Integrity and Availability. Various frameworks aiming at countering the XML based attacks were designed and developed.The Analysis of the frameworks available for countering the XML-based attacks simulated in the SOAP messages is presented benefiting the future researchers and also provides insight of various attack simulations and the countermeasures respectively. The parameters responsible for evaluating the strength of the frameworks were also specified and discussed as part of this work.","internal_url":"https://www.academia.edu/112650766/Analysis_on_Countering_XML_Based_Attacks_in_Web_Services","translated_internal_url":"","created_at":"2023-12-30T23:06:25.767-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Analysis_on_Countering_XML_Based_Attacks_in_Web_Services","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":5279,"name":"XML","url":"https://www.academia.edu/Documents/in/XML"},{"id":13923,"name":"Computer Security","url":"https://www.academia.edu/Documents/in/Computer_Security"},{"id":26860,"name":"Cloud Computing","url":"https://www.academia.edu/Documents/in/Cloud_Computing"},{"id":316280,"name":"SOAP","url":"https://www.academia.edu/Documents/in/SOAP"},{"id":317992,"name":"Web Service","url":"https://www.academia.edu/Documents/in/Web_Service"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650765/Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants"><img alt="Research paper thumbnail of Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants" class="work-thumbnail" src="https://attachments.academia-assets.com/109815184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650765/Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants">Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants</a></div><div class="wp-workCard_item"><span>The Journal of infectious diseases</span><span>, Jun 9, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated"> We sought to understand why some children respond poorly to vaccinations in the first year of li...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden"> We sought to understand why some children respond poorly to vaccinations in the first year of life. A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell (PBMC) samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed by ELISA, and frequency of memory B-cells, functional T-cell responses, and APC responses were assessed in PBMC samples by flow cytometric analysis. 11% of children were low vaccine responders (LVRs) defined a priori as those with sub-protective IgG antibody levels to ≥66% of vaccines tested. LVRs generated fewer memory B-cells, had reduced activation by CD4+ and CD8+ T-cells upon polyclonal stimulation, and displayed lower MHC II expression by APCs. We conclude that sub-protective vaccine responses in infants are associated with a distinct immunologic profile.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a707a71816b7d2f78255e1f8621550fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815184,"asset_id":112650765,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815184/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650765]").text(description); $(".js-view-count[data-work-id=112650765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a707a71816b7d2f78255e1f8621550fe" } } $('.js-work-strip[data-work-id=112650765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650765,"title":"Functional Immune Cell Differences Associated with Low Vaccine Responses in Infants","translated_title":"","metadata":{"abstract":" We sought to understand why some children respond poorly to vaccinations in the first year of life. A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell (PBMC) samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed by ELISA, and frequency of memory B-cells, functional T-cell responses, and APC responses were assessed in PBMC samples by flow cytometric analysis. 11% of children were low vaccine responders (LVRs) defined a priori as those with sub-protective IgG antibody levels to ≥66% of vaccines tested. LVRs generated fewer memory B-cells, had reduced activation by CD4+ and CD8+ T-cells upon polyclonal stimulation, and displayed lower MHC II expression by APCs. We conclude that sub-protective vaccine responses in infants are associated with a distinct immunologic profile.","publication_date":{"day":9,"month":6,"year":2016,"errors":{}},"publication_name":"The Journal of infectious diseases"},"translated_abstract":" We sought to understand why some children respond poorly to vaccinations in the first year of life. A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell (PBMC) samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed by ELISA, and frequency of memory B-cells, functional T-cell responses, and APC responses were assessed in PBMC samples by flow cytometric analysis. 11% of children were low vaccine responders (LVRs) defined a priori as those with sub-protective IgG antibody levels to ≥66% of vaccines tested. LVRs generated fewer memory B-cells, had reduced activation by CD4+ and CD8+ T-cells upon polyclonal stimulation, and displayed lower MHC II expression by APCs. We conclude that sub-protective vaccine responses in infants are associated with a distinct immunologic profile.","internal_url":"https://www.academia.edu/112650765/Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants","translated_internal_url":"","created_at":"2023-12-30T23:06:25.373-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109815184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109815184/thumbnails/1.jpg","file_name":"jiw053.pdf","download_url":"https://www.academia.edu/attachments/109815184/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Functional_Immune_Cell_Differences_Assoc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109815184/jiw053-libre.pdf?1704007688=\u0026response-content-disposition=attachment%3B+filename%3DFunctional_Immune_Cell_Differences_Assoc.pdf\u0026Expires=1733023616\u0026Signature=WwDd1cKbY2AuhkIMJzAC68PoeSOBKC3bJbQZXA-SWzfVK3XcIySGz0dX1BBMUoWIkSDTjM0-QM2FTDNAShTcX582TlRoLYsr-q8-2-DcodWDbTjj~IqgfTdBxWc74WQqBTKMY~e86yOQKCwUK3bx26sPatLp6dxPEXGfZvF3sn0JTkYQQvBGX8au0UiHZzoHJN~2NvrpCBXWYIRgvPzF7mhp6bVwcgnsFb48hg-FdqIhTeBxh350jGxMGQI~-FSt1nDtoKTaPTY~FDuXbiTfG1wMUm6~loP0-SSq~bmIRyXY2H0VTSX~9Ys2fU2o6PD8T23PUdz9j~GWbys3JmPaow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Functional_Immune_Cell_Differences_Associated_with_Low_Vaccine_Responses_in_Infants","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[{"id":109815184,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109815184/thumbnails/1.jpg","file_name":"jiw053.pdf","download_url":"https://www.academia.edu/attachments/109815184/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Functional_Immune_Cell_Differences_Assoc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109815184/jiw053-libre.pdf?1704007688=\u0026response-content-disposition=attachment%3B+filename%3DFunctional_Immune_Cell_Differences_Assoc.pdf\u0026Expires=1733023616\u0026Signature=WwDd1cKbY2AuhkIMJzAC68PoeSOBKC3bJbQZXA-SWzfVK3XcIySGz0dX1BBMUoWIkSDTjM0-QM2FTDNAShTcX582TlRoLYsr-q8-2-DcodWDbTjj~IqgfTdBxWc74WQqBTKMY~e86yOQKCwUK3bx26sPatLp6dxPEXGfZvF3sn0JTkYQQvBGX8au0UiHZzoHJN~2NvrpCBXWYIRgvPzF7mhp6bVwcgnsFb48hg-FdqIhTeBxh350jGxMGQI~-FSt1nDtoKTaPTY~FDuXbiTfG1wMUm6~loP0-SSq~bmIRyXY2H0VTSX~9Ys2fU2o6PD8T23PUdz9j~GWbys3JmPaow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines"},{"id":16061,"name":"Polysaccharides","url":"https://www.academia.edu/Documents/in/Polysaccharides"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":51789,"name":"Antibodies","url":"https://www.academia.edu/Documents/in/Antibodies"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":553115,"name":"Pertussis Vaccine","url":"https://www.academia.edu/Documents/in/Pertussis_Vaccine"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1792514,"name":"Antigen presenting cells","url":"https://www.academia.edu/Documents/in/Antigen_presenting_cells"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650764"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650764/Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae"><img alt="Research paper thumbnail of Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112650764/Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae">Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae</a></div><div class="wp-workCard_item"><span>Expert review of vaccines</span><span>, Jul 19, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory naso...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650764"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650764"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650764; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650764]").text(description); $(".js-view-count[data-work-id=112650764]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650764; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650764']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650764, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112650764]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650764,"title":"Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae","translated_title":"","metadata":{"abstract":"Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.","publication_date":{"day":19,"month":7,"year":2016,"errors":{}},"publication_name":"Expert review of vaccines"},"translated_abstract":"Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in children and vulnerable populations such as the elderly and those with chronic obstructive pulmonary disease (COPD). One NTHi protein is included in a pneumococcal conjugate vaccine and has been shown to provide efficacy. Our lab has been interested in understanding the immunogenicity of NTHi vaccine candidates P6, PD and OMP26 for preventing acute otitis media in young children. We expect that continued investigation and progress in the development of an efficacious protein based vaccine against NTHi infections is achievable in the near future.","internal_url":"https://www.academia.edu/112650764/Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae","translated_internal_url":"","created_at":"2023-12-30T23:06:25.208-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":271018186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Developing_a_vaccine_to_prevent_otitis_media_caused_by_nontypeable_Haemophilus_influenzae","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":271018186,"first_name":"Saleem Basha","middle_initials":null,"last_name":"S","page_name":"SaleemBashaS","domain_name":"independent","created_at":"2023-05-24T03:09:54.099-07:00","display_name":"Saleem Basha S","url":"https://independent.academia.edu/SaleemBashaS"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":10640,"name":"Drug Discovery","url":"https://www.academia.edu/Documents/in/Drug_Discovery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":111112,"name":"Pneumonia","url":"https://www.academia.edu/Documents/in/Pneumonia"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":509607,"name":"Otitis Media","url":"https://www.academia.edu/Documents/in/Otitis_Media"},{"id":1314192,"name":"Immunogenicity","url":"https://www.academia.edu/Documents/in/Immunogenicity"},{"id":1533489,"name":"Haemophilus Infections Market","url":"https://www.academia.edu/Documents/in/Haemophilus_Infections_Market"},{"id":1990998,"name":"Haemophilus influenzae","url":"https://www.academia.edu/Documents/in/Haemophilus_influenzae"},{"id":4148508,"name":"Otitis","url":"https://www.academia.edu/Documents/in/Otitis"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112650763/Why_Cryptosystem_Fails_How_to_Overcome"><img alt="Research paper thumbnail of Why Cryptosystem Fails? 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Gelatin and sodium alginate have proven to own wound healing properties individually. Hence the combination of these two polymers and incorporation of drugs into their matrices may show a synergistic improvement in wound healing activity. Hence, the objective of this study was to evaluate the efficacy of sustained release of aminoglycoside antibiotic gentamycin from gelatin-alginate matrix, in order to establish a new delivery system for local anti-infective therapy. Thus, the drug loaded Gelatin-alginate matrices were prepared with two different gelatin concentrations (3% and 5%) and evaluated for various in vitro evaluation tests like swelling capacity, drug loading efficiency, SEM, FT-IR, in-vitro drug release by diffusion studies, antibacterial activity, and wound healing studies. 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To overcome these deficien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Current information retrieval systems face three inherent limitations. To overcome these deficiencies, a multidimensional match model was proposed to use context as an independent dimension besides content dimension. All contexts were classified into two parts: context about users and context about documents. The Discounted Cumulative Gain was introduced to evaluate the search results. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650758"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650758/Immune_responses_in_neonates"><img alt="Research paper thumbnail of Immune responses in neonates" class="work-thumbnail" src="https://attachments.academia-assets.com/109815177/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650758/Immune_responses_in_neonates">Immune responses in neonates</a></div><div class="wp-workCard_item"><span>Expert Review of Clinical Immunology</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dcccb7ed281a693ea3cb94b5d733e4a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815177,"asset_id":112650758,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815177/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650758"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650758"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650758; 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Recent advances in understanding of neonatal immunity indicate that both innate and adaptive responses are dependent on precursor frequency of lymphocytes, antigenic dose and mode of exposure. Studies in neonatal mouse models and human umbilical cord blood cells demonstrate the capability of neonatal immune cells to produce immune responses similar to adults in some aspects but not others. This review focuses mainly on the developmental and functional mechanisms of the human neonatal immune system. In particular, the mechanism of innate and adaptive immunity and the role of neutrophils, antigen presenting cells, differences in subclasses of T lymphocytes (Th1, Th2, Tregs) and B cells are discussed. In addition, we have included the recent developments in neonatal mouse immune system. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650757"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650757/An_Overview_of_Web_Services_Composition_Approaches"><img alt="Research paper thumbnail of An Overview of Web Services Composition Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/109815176/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650757/An_Overview_of_Web_Services_Composition_Approaches">An Overview of Web Services Composition Approaches</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba0624e29f8167e17face7474bd6900b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815176,"asset_id":112650757,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815176/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650757"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650757"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650757; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650756"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650756/Web_Service_Based_Secure_E_Learning_Management_System_EWeMS"><img alt="Research paper thumbnail of Web Service Based Secure E-Learning Management System - EWeMS" class="work-thumbnail" src="https://attachments.academia-assets.com/110060160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650756/Web_Service_Based_Secure_E_Learning_Management_System_EWeMS">Web Service Based Secure E-Learning Management System - EWeMS</a></div><div class="wp-workCard_item"><span>Journal of Convergence Information Technology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f9536faec703d134960a9d32e2ad35d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110060160,"asset_id":112650756,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110060160/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650756"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650756"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650756; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650756]").text(description); $(".js-view-count[data-work-id=112650756]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650756; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650756']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650756, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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The learners do not have to travel for acquiring knowledge through e-learning. Learning is the ability of the learner to enhance his character and behavior. One of the most important roles of the information and communication technology is to provide e-learning. E-learning fulfils the thirst of knowledge for the learner at any location, time and age while compared with classical learning system. This paper aim to provide the web service based secure e-learning management system (EWeMS) to address the issues and challenges of the traditional E-learning Management System (EMS). EWeMS are superior in terms of convenience, agile, reusability, independence, adaptation, and interaction. EWeMS provides an environment for management and e-learning strategy. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112650755"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112650755/A_Comparative_Analysis_of_Scheduling_Policies_in_Cloud_Computing_Environment"><img alt="Research paper thumbnail of A Comparative Analysis of Scheduling Policies in Cloud Computing Environment" class="work-thumbnail" src="https://attachments.academia-assets.com/109815175/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650755/A_Comparative_Analysis_of_Scheduling_Policies_in_Cloud_Computing_Environment">A Comparative Analysis of Scheduling Policies in Cloud Computing Environment</a></div><div class="wp-workCard_item"><span>International Journal of Computer Applications</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b793e067b5786086758c23f1c4bd459" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815175,"asset_id":112650755,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815175/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650755"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650755"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650755; 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receptors" class="work-thumbnail" src="https://attachments.academia-assets.com/109815186/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112650753/Polyvalent_inhibitors_of_anthrax_toxin_that_target_host_receptors">Polyvalent inhibitors of anthrax toxin that target host receptors</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance can emerge naturally, but it can also be engineered intentionally, which is an important consideration in designing therapeutics for bioterrorism agents. Blocking host receptors used by pathogens represents a powerful strategy to overcome this problem, because extensive alterations to the pathogen may be required to enable it to switch to a new receptor that can still support pathogenesis. Here, we demonstrate a facile method for producing potent receptor-directed antitoxins. We used phage display to identify a peptide that binds both anthrax-toxin receptors and attached this peptide to a synthetic scaffold. Polyvalency increased the potency of these peptides by &gt;50,000-fold in vitro and enabled the neutralization of anthrax toxin in vivo . This work demonstrates a receptor-directed anthrax-toxin inhibitor and represents a promising strategy to combat a variety of viral and bacterial...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e408c931aa63868fad8e95df21498ca" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109815186,"asset_id":112650753,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109815186/download_file?st=MTczMzAzODE2NSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112650753"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112650753"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112650753; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112650753]").text(description); $(".js-view-count[data-work-id=112650753]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112650753; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112650753']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112650753, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e408c931aa63868fad8e95df21498ca" } } $('.js-work-strip[data-work-id=112650753]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112650753,"title":"Polyvalent inhibitors of anthrax toxin that target host receptors","translated_title":"","metadata":{"abstract":"Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance can emerge naturally, but it can also be engineered intentionally, which is an important consideration in designing therapeutics for bioterrorism agents. Blocking host receptors used by pathogens represents a powerful strategy to overcome this problem, because extensive alterations to the pathogen may be required to enable it to switch to a new receptor that can still support pathogenesis. Here, we demonstrate a facile method for producing potent receptor-directed antitoxins. We used phage display to identify a peptide that binds both anthrax-toxin receptors and attached this peptide to a synthetic scaffold. Polyvalency increased the potency of these peptides by \u0026gt;50,000-fold in vitro and enabled the neutralization of anthrax toxin in vivo . This work demonstrates a receptor-directed anthrax-toxin inhibitor and represents a promising strategy to combat a variety of viral and bacterial...","publisher":"Proceedings of the National Academy of Sciences","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Proceedings of the National Academy of Sciences"},"translated_abstract":"Resistance of pathogens to antimicrobial therapeutics has become a widespread problem. Resistance can emerge naturally, but it can also be engineered intentionally, which is an important consideration in designing therapeutics for bioterrorism agents. Blocking host receptors used by pathogens represents a powerful strategy to overcome this problem, because extensive alterations to the pathogen may be required to enable it to switch to a new receptor that can still support pathogenesis. Here, we demonstrate a facile method for producing potent receptor-directed antitoxins. We used phage display to identify a peptide that binds both anthrax-toxin receptors and attached this peptide to a synthetic scaffold. Polyvalency increased the potency of these peptides by \u0026gt;50,000-fold in vitro and enabled the neutralization of anthrax toxin in vivo . 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