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class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by YiTing Chen</h3></div><div class="js-work-strip profile--work_container" data-work-id="83480763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83480763/Systematic_verification_of_bladder_cancer_associated_tissue_protein_biomarker_candidates_in_clinical_urine_specimens"><img alt="Research paper thumbnail of Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens" class="work-thumbnail" src="https://attachments.academia-assets.com/88808577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83480763/Systematic_verification_of_bladder_cancer_associated_tissue_protein_biomarker_candidates_in_clinical_urine_specimens">Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens</a></div><div class="wp-workCard_item"><span>Oncotarget</span><span>, Jan 20, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficiently reliable for use in non-invasive clinical diagnosis. Verification/validation of numerous biomarker candidates for BC detection is a crucial bottleneck for novel biomarker development. A multiplexed liquid chromatography multiple-reaction-monitoring mass spectrometry assay of 122 proteins, including 118 up-regulated tissue proteins, two known bladder cancer biomarkers and two housekeeping gene products, was successfully established for protein quantification in clinical urine specimens. Quantification of 122 proteins was performed on a large cohort of urine specimens representing a variety of conditions, including 142 hernia, 126 bladder cancer, 67 hematuria, and 59 urinary tract infection samples. ANXA3 (annexin A3) and HSPE1 (heat shock protein family E member 1), which showed the highest detection frequency in bladder cancer samples, were selected for further validation. Western blo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef262c743f4276afb36db6d8df60db75" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88808577,"asset_id":83480763,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88808577/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83480763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83480763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83480763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83480763]").text(description); $(".js-view-count[data-work-id=83480763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83480763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83480763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83480763, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef262c743f4276afb36db6d8df60db75" } } $('.js-work-strip[data-work-id=83480763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83480763,"title":"Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens","translated_title":"","metadata":{"abstract":"Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficiently reliable for use in non-invasive clinical diagnosis. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83004504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83004504/Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer"><img alt="Research paper thumbnail of Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/88509934/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83004504/Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer">Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer</a></div><div class="wp-workCard_item"><span>Molecular & cellular proteomics : MCP</span><span>, Jan 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximatel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximately 150200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, iTRAQ labeling, and LC-MS/MS analysis to profile proteomic changes in fresh-frozen bladder tumor specimens. Cellular proteins from four pairs of surgically resected primary bladder cancer tumor and adjacent non-tumorous tissue were extracted for use in two batches of iTRAQ experiments, which identified a total of 3220 proteins. A DAVID analysis of dysregulated proteins revealed that the three top-ranking biological processes were extracellular matrix organization, extracellular structure organization, and oxidation-reduction. Biological processes including response to organic substances, response to metal ions, and response to inorganic substances were highlighted by up-expressed proteins in bladder cancer. Seven differentially expressed proteins were sel...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89ab4bd378b2ed5977228320f2da28d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88509934,"asset_id":83004504,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88509934/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83004504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83004504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83004504; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83004504]").text(description); $(".js-view-count[data-work-id=83004504]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83004504; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83004504']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83004504, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "89ab4bd378b2ed5977228320f2da28d5" } } $('.js-work-strip[data-work-id=83004504]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83004504,"title":"Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer","translated_title":"","metadata":{"abstract":"More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximately 150200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, iTRAQ labeling, and LC-MS/MS analysis to profile proteomic changes in fresh-frozen bladder tumor specimens. Cellular proteins from four pairs of surgically resected primary bladder cancer tumor and adjacent non-tumorous tissue were extracted for use in two batches of iTRAQ experiments, which identified a total of 3220 proteins. A DAVID analysis of dysregulated proteins revealed that the three top-ranking biological processes were extracellular matrix organization, extracellular structure organization, and oxidation-reduction. Biological processes including response to organic substances, response to metal ions, and response to inorganic substances were highlighted by up-expressed proteins in bladder cancer. Seven differentially expressed proteins were sel...","publication_date":{"day":16,"month":1,"year":2015,"errors":{}},"publication_name":"Molecular \u0026 cellular proteomics : MCP"},"translated_abstract":"More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximately 150200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, iTRAQ labeling, and LC-MS/MS analysis to profile proteomic changes in fresh-frozen bladder tumor specimens. Cellular proteins from four pairs of surgically resected primary bladder cancer tumor and adjacent non-tumorous tissue were extracted for use in two batches of iTRAQ experiments, which identified a total of 3220 proteins. A DAVID analysis of dysregulated proteins revealed that the three top-ranking biological processes were extracellular matrix organization, extracellular structure organization, and oxidation-reduction. Biological processes including response to organic substances, response to metal ions, and response to inorganic substances were highlighted by up-expressed proteins in bladder cancer. Seven differentially expressed proteins were sel...","internal_url":"https://www.academia.edu/83004504/Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer","translated_internal_url":"","created_at":"2022-07-12T03:05:45.313-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":21739390,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":88509934,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88509934/thumbnails/1.jpg","file_name":"356f1a66e7a030ebc4e05570c5b22071b3e3.pdf","download_url":"https://www.academia.edu/attachments/88509934/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparative_Tissue_Proteomics_of_Microdi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88509934/356f1a66e7a030ebc4e05570c5b22071b3e3-libre.pdf?1657645906=\u0026response-content-disposition=attachment%3B+filename%3DComparative_Tissue_Proteomics_of_Microdi.pdf\u0026Expires=1732479704\u0026Signature=JrsKIdKpZmg~~X~mScCzdewjZVfIbf-HdUHFElMaIkom~DHM~ICgoGd-X8RQzbOkt-B3AK72tqduuyDECk6HDgDnswFkFBaAO90aWKmYVt5Cy2XgVFQjqcCFZKQq8bLFUQ5NttAiGjfeJG0vvK4nZPHqiTIf4IwbKGUddMLB5plJ04jECVjp2b0i3mR98Xp9PvBytKBgzwnIFdJz-wXlMxLbeKZJKrnZODdKk0-tDTeviYa9OdTz-thlNIlCsDky-uz0FVV5GnbNndo4xlBRoukftbQPHNJHiZAgEvywgqmm4rdx9ucmqSUV5o3JEIqhaBLK45f26avOcyvXLmaTqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":21739390,"first_name":"YiTing","middle_initials":null,"last_name":"Chen","page_name":"YiTingChen3","domain_name":"independent","created_at":"2014-11-18T09:56:15.352-08:00","display_name":"YiTing Chen","url":"https://independent.academia.edu/YiTingChen3"},"attachments":[{"id":88509934,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/88509934/thumbnails/1.jpg","file_name":"356f1a66e7a030ebc4e05570c5b22071b3e3.pdf","download_url":"https://www.academia.edu/attachments/88509934/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparative_Tissue_Proteomics_of_Microdi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/88509934/356f1a66e7a030ebc4e05570c5b22071b3e3-libre.pdf?1657645906=\u0026response-content-disposition=attachment%3B+filename%3DComparative_Tissue_Proteomics_of_Microdi.pdf\u0026Expires=1732479704\u0026Signature=JrsKIdKpZmg~~X~mScCzdewjZVfIbf-HdUHFElMaIkom~DHM~ICgoGd-X8RQzbOkt-B3AK72tqduuyDECk6HDgDnswFkFBaAO90aWKmYVt5Cy2XgVFQjqcCFZKQq8bLFUQ5NttAiGjfeJG0vvK4nZPHqiTIf4IwbKGUddMLB5plJ04jECVjp2b0i3mR98Xp9PvBytKBgzwnIFdJz-wXlMxLbeKZJKrnZODdKk0-tDTeviYa9OdTz-thlNIlCsDky-uz0FVV5GnbNndo4xlBRoukftbQPHNJHiZAgEvywgqmm4rdx9ucmqSUV5o3JEIqhaBLK45f26avOcyvXLmaTqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9786,"name":"Proteomics","url":"https://www.academia.edu/Documents/in/Proteomics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":82990,"name":"Microdissection","url":"https://www.academia.edu/Documents/in/Microdissection"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry"},{"id":225787,"name":"High Performance Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Performance_Liquid_Chromatography"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":573990,"name":"Stathmin","url":"https://www.academia.edu/Documents/in/Stathmin"},{"id":4102912,"name":"Urinary bladder neoplasms","url":"https://www.academia.edu/Documents/in/Urinary_bladder_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="9376388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/9376388/Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution"><img alt="Research paper thumbnail of Resource Search in Peer-to-Peer Network Based on Power Law Distribution" class="work-thumbnail" src="https://attachments.academia-assets.com/47804628/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/9376388/Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution">Resource Search in Peer-to-Peer Network Based on Power Law Distribution</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The resource distribution in P2P network has an obvious scale free character. Using this inherent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The resource distribution in P2P network has an obvious scale free character. Using this inherent character to design resource search strategy is great significant for improving searching efficiency and reducing the costs. We analyze the scale free distribution character in P2P network, and propose a reliable random walk search algorithm to achieve high and reliable search efficiency through forwarding query messages based on the P2P scale free distribution. Moreover, we design simulation experiments to evaluate the performance of reliable random walk. The experimental results show that the reliable random walk is a scalable resource searching algorithm with high search efficiency and low costs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d967edf1d9d5c242e564880a9583c93d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47804628,"asset_id":9376388,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47804628/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="9376388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="9376388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9376388; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9376388]").text(description); $(".js-view-count[data-work-id=9376388]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9376388; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='9376388']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 9376388, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d967edf1d9d5c242e564880a9583c93d" } } $('.js-work-strip[data-work-id=9376388]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":9376388,"title":"Resource Search in Peer-to-Peer Network Based on Power Law Distribution","translated_title":"","metadata":{"abstract":"The resource distribution in P2P network has an obvious scale free character. Using this inherent character to design resource search strategy is great significant for improving searching efficiency and reducing the costs. We analyze the scale free distribution character in P2P network, and propose a reliable random walk search algorithm to achieve high and reliable search efficiency through forwarding query messages based on the P2P scale free distribution. Moreover, we design simulation experiments to evaluate the performance of reliable random walk. The experimental results show that the reliable random walk is a scalable resource searching algorithm with high search efficiency and low costs.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"The resource distribution in P2P network has an obvious scale free character. Using this inherent character to design resource search strategy is great significant for improving searching efficiency and reducing the costs. We analyze the scale free distribution character in P2P network, and propose a reliable random walk search algorithm to achieve high and reliable search efficiency through forwarding query messages based on the P2P scale free distribution. Moreover, we design simulation experiments to evaluate the performance of reliable random walk. The experimental results show that the reliable random walk is a scalable resource searching algorithm with high search efficiency and low costs.","internal_url":"https://www.academia.edu/9376388/Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution","translated_internal_url":"","created_at":"2014-11-18T09:58:31.672-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":21739390,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":47804628,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47804628/thumbnails/1.jpg","file_name":"rrw.pdf","download_url":"https://www.academia.edu/attachments/47804628/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Resource_Search_in_Peer_to_Peer_Network.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47804628/rrw-libre.pdf?1470372375=\u0026response-content-disposition=attachment%3B+filename%3DResource_Search_in_Peer_to_Peer_Network.pdf\u0026Expires=1732479704\u0026Signature=ZVxguNK4nLLLITYoHvm~zwu2MRbFc-CRd78-bnmHqz-X48AlQas6GEisljM4r9l6D8jHz7KaWDFx5Vgf9-WQZEXKNdFQdxZ7-J-ehwFchER0MPELvuwoxYLqoQBqj8gK11C251yy9mpKc-vvjcOSIpTi~aJCdEwZXzAbICcOLSWJ3arPRvIrpfsVZs9jjNsuToARagUTTqnb0GwVUaRxl~Y8Vtb1giaTsdskoFhqUN~McGlHP10xiucxCs6clSqarv01HlBwj7Y9SmvYUUFbJ5AZZPKZPUyiFi7nbND6HzBksX~R82T29fF~Xdrie4t9yo4NnbZCshBM9upezANMcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":21739390,"first_name":"YiTing","middle_initials":null,"last_name":"Chen","page_name":"YiTingChen3","domain_name":"independent","created_at":"2014-11-18T09:56:15.352-08:00","display_name":"YiTing Chen","url":"https://independent.academia.edu/YiTingChen3"},"attachments":[{"id":47804628,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47804628/thumbnails/1.jpg","file_name":"rrw.pdf","download_url":"https://www.academia.edu/attachments/47804628/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Resource_Search_in_Peer_to_Peer_Network.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47804628/rrw-libre.pdf?1470372375=\u0026response-content-disposition=attachment%3B+filename%3DResource_Search_in_Peer_to_Peer_Network.pdf\u0026Expires=1732479704\u0026Signature=ZVxguNK4nLLLITYoHvm~zwu2MRbFc-CRd78-bnmHqz-X48AlQas6GEisljM4r9l6D8jHz7KaWDFx5Vgf9-WQZEXKNdFQdxZ7-J-ehwFchER0MPELvuwoxYLqoQBqj8gK11C251yy9mpKc-vvjcOSIpTi~aJCdEwZXzAbICcOLSWJ3arPRvIrpfsVZs9jjNsuToARagUTTqnb0GwVUaRxl~Y8Vtb1giaTsdskoFhqUN~McGlHP10xiucxCs6clSqarv01HlBwj7Y9SmvYUUFbJ5AZZPKZPUyiFi7nbND6HzBksX~R82T29fF~Xdrie4t9yo4NnbZCshBM9upezANMcg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":51281,"name":"Networks Security","url":"https://www.academia.edu/Documents/in/Networks_Security"},{"id":78086,"name":"Random Walk","url":"https://www.academia.edu/Documents/in/Random_Walk"},{"id":92702,"name":"Scale-Free Networks","url":"https://www.academia.edu/Documents/in/Scale-Free_Networks"},{"id":99499,"name":"Complex network","url":"https://www.academia.edu/Documents/in/Complex_network"},{"id":119610,"name":"Mobile Peer-to-Peer Network","url":"https://www.academia.edu/Documents/in/Mobile_Peer-to-Peer_Network"},{"id":155564,"name":"Search Algorithm","url":"https://www.academia.edu/Documents/in/Search_Algorithm"},{"id":290886,"name":"Peer to Peer","url":"https://www.academia.edu/Documents/in/Peer_to_Peer"},{"id":550568,"name":"Simulation experiment","url":"https://www.academia.edu/Documents/in/Simulation_experiment"},{"id":1482264,"name":"Power Law Distribution","url":"https://www.academia.edu/Documents/in/Power_Law_Distribution"}],"urls":[{"id":3864693,"url":"http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5481116"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="2157404" id="papers"><div class="js-work-strip profile--work_container" data-work-id="83480763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83480763/Systematic_verification_of_bladder_cancer_associated_tissue_protein_biomarker_candidates_in_clinical_urine_specimens"><img alt="Research paper thumbnail of Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens" class="work-thumbnail" src="https://attachments.academia-assets.com/88808577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83480763/Systematic_verification_of_bladder_cancer_associated_tissue_protein_biomarker_candidates_in_clinical_urine_specimens">Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens</a></div><div class="wp-workCard_item"><span>Oncotarget</span><span>, Jan 20, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficiently reliable for use in non-invasive clinical diagnosis. Verification/validation of numerous biomarker candidates for BC detection is a crucial bottleneck for novel biomarker development. A multiplexed liquid chromatography multiple-reaction-monitoring mass spectrometry assay of 122 proteins, including 118 up-regulated tissue proteins, two known bladder cancer biomarkers and two housekeeping gene products, was successfully established for protein quantification in clinical urine specimens. Quantification of 122 proteins was performed on a large cohort of urine specimens representing a variety of conditions, including 142 hernia, 126 bladder cancer, 67 hematuria, and 59 urinary tract infection samples. ANXA3 (annexin A3) and HSPE1 (heat shock protein family E member 1), which showed the highest detection frequency in bladder cancer samples, were selected for further validation. Western blo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef262c743f4276afb36db6d8df60db75" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88808577,"asset_id":83480763,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88808577/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83480763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83480763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83480763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83480763]").text(description); $(".js-view-count[data-work-id=83480763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83480763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83480763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83480763, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef262c743f4276afb36db6d8df60db75" } } $('.js-work-strip[data-work-id=83480763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83480763,"title":"Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens","translated_title":"","metadata":{"abstract":"Bladder cancer biomarkers currently approved by the Food and Drug Administration are insufficiently reliable for use in non-invasive clinical diagnosis. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="83004504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/83004504/Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer"><img alt="Research paper thumbnail of Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/88509934/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/83004504/Comparative_Tissue_Proteomics_of_Microdissected_Specimens_Reveals_Novel_Candidate_Biomarkers_of_Bladder_Cancer">Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer</a></div><div class="wp-workCard_item"><span>Molecular & cellular proteomics : MCP</span><span>, Jan 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximatel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximately 150200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, iTRAQ labeling, and LC-MS/MS analysis to profile proteomic changes in fresh-frozen bladder tumor specimens. Cellular proteins from four pairs of surgically resected primary bladder cancer tumor and adjacent non-tumorous tissue were extracted for use in two batches of iTRAQ experiments, which identified a total of 3220 proteins. A DAVID analysis of dysregulated proteins revealed that the three top-ranking biological processes were extracellular matrix organization, extracellular structure organization, and oxidation-reduction. Biological processes including response to organic substances, response to metal ions, and response to inorganic substances were highlighted by up-expressed proteins in bladder cancer. Seven differentially expressed proteins were sel...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="89ab4bd378b2ed5977228320f2da28d5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":88509934,"asset_id":83004504,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/88509934/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="83004504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="83004504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 83004504; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=83004504]").text(description); $(".js-view-count[data-work-id=83004504]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 83004504; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='83004504']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 83004504, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "89ab4bd378b2ed5977228320f2da28d5" } } $('.js-work-strip[data-work-id=83004504]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":83004504,"title":"Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer","translated_title":"","metadata":{"abstract":"More than 380000 new cases of bladder cancer are diagnosed worldwide, accounting for approximately 150200 deaths each year. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="9376388"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/9376388/Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution"><img alt="Research paper thumbnail of Resource Search in Peer-to-Peer Network Based on Power Law Distribution" class="work-thumbnail" src="https://attachments.academia-assets.com/47804628/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/9376388/Resource_Search_in_Peer_to_Peer_Network_Based_on_Power_Law_Distribution">Resource Search in Peer-to-Peer Network Based on Power Law Distribution</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The resource distribution in P2P network has an obvious scale free character. Using this inherent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The resource distribution in P2P network has an obvious scale free character. Using this inherent character to design resource search strategy is great significant for improving searching efficiency and reducing the costs. We analyze the scale free distribution character in P2P network, and propose a reliable random walk search algorithm to achieve high and reliable search efficiency through forwarding query messages based on the P2P scale free distribution. Moreover, we design simulation experiments to evaluate the performance of reliable random walk. The experimental results show that the reliable random walk is a scalable resource searching algorithm with high search efficiency and low costs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d967edf1d9d5c242e564880a9583c93d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47804628,"asset_id":9376388,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47804628/download_file?st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&st=MTczMjQ3NjEwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="9376388"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="9376388"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9376388; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9376388]").text(description); $(".js-view-count[data-work-id=9376388]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9376388; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='9376388']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 9376388, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d967edf1d9d5c242e564880a9583c93d" } } $('.js-work-strip[data-work-id=9376388]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":9376388,"title":"Resource Search in Peer-to-Peer Network Based on Power Law Distribution","translated_title":"","metadata":{"abstract":"The resource distribution in P2P network has an obvious scale free character. 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