Editor’s Choice Articles from CJN

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data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"DA0641BDCCD2ED53444606C8516725C3","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="DA0641BDCCD2ED53444606C8516725C3" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="301031" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/systematic-review-of-the-genetics-and-pathology-of-psychosis-in-frontotemporal-dementia/DA0641BDCCD2ED53444606C8516725C3"> A Systematic Review of the Genetics and Pathology of Psychosis in Frontotemporal Dementia </a></h3></li> <li> Part of: <ul 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Hsiung</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 51 / <a href="/core/product/F17B7DED3452BAE2F80BBAF70AC92B7F" class="productParent" data-prod-id="F17B7DED3452BAE2F80BBAF70AC92B7F">Issue 3</a> / May 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 29 June 2023</span><span class="pages">, pp. 369-378</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" 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'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="DA0641BDCCD2ED53444606C8516725C3" data-container="representation" aria-label="Export citation for A Systematic Review of the Genetics and Pathology of Psychosis in Frontotemporal Dementia">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167123002482')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for A Systematic Review of the Genetics and Pathology of Psychosis in Frontotemporal Dementia" 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7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167123002482" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objectives:</span><p>Frontotemporal dementia (FTD) patients frequently present with psychosis, which complicates diagnosis and management. In this study, we aim to examine the relationship between psychosis and the most common genetic mutations predisposing to FTD, and in the different pathological subtypes of FTD.</p></div><div class='sec'><span class="bold">Design:</span><p>We conducted a systematic review, searching the literature up to December 2022, and reviewed 50 articles that met our inclusion criteria. From the reviewed articles, we extracted and summarized data regarding the frequency of psychosis and patient characteristics in each major genetic and pathological subtype of FTD.</p></div><div class='sec'><span class="bold">Results:</span><p>Among FTD patients with confirmed genetic mutations or pathological diagnosss, the frequency of psychosis was 24.2%. Among the genetic mutation carriers, <span class='italic'>C9orf72</span> mutation carriers had the highest frequency of psychosis (31.4%), whereas <span class='italic'>GRN</span> (15.0%) and <span class='italic'>MAPT</span> (9.2%) mutation carriers had lower frequencies of psychosis. <span class='italic'>MAPT</span> mutation carriers notably developed psychosis at a younger age compared to other genetic groups. The most common psychotic symptoms were delusions among <span class='italic'>C9orf72</span> carriers and visual hallucinations among GRN mutation carriers. Among the pathological subtypes, 30% of patients with FUS pathology, 25.3% of patients with TDP-43 pathology, and 16.4% of patients with tau pathology developed psychosis. In the TDP-43 group, subtype B pathology was the most common subtype reported in association with psychosis.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Our systematic review suggests a high frequency of psychosis in specific subgroups of FTD patients. Further studies are required to understand the structural and biological underpinnings of psychosis in FTD.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2023.248" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2023.248" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="9A18B6326F61CA073DA9BE5D0E6855CB" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"9A18B6326F61CA073DA9BE5D0E6855CB","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="9A18B6326F61CA073DA9BE5D0E6855CB" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="515587" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/direct-to-angiosuite-in-acute-stroke-with-mobile-stroke-unit/9A18B6326F61CA073DA9BE5D0E6855CB"> Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Radhika Nair&eventCode=SE-AU" class="more-by-this-author ">Radhika Nair</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jeremy Rempel&eventCode=SE-AU" class="more-by-this-author ">Jeremy Rempel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Khurshid Khan&eventCode=SE-AU" class="more-by-this-author ">Khurshid Khan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Thomas Jeerakathil&eventCode=SE-AU" class="more-by-this-author ">Thomas Jeerakathil</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rene Van Dijk&eventCode=SE-AU" class="more-by-this-author ">Rene Van Dijk</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian H. 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Kate</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sibi Thirunavukkarasu&eventCode=SE-AU" class="more-by-this-author ">Sibi Thirunavukkarasu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kimberly Gilbertson&eventCode=SE-AU" class="more-by-this-author ">Kimberly Gilbertson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sathvika Thermalingem&eventCode=SE-AU" class="more-by-this-author ">Sathvika Thermalingem</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ashfaq Shuaib&eventCode=SE-AU" class="more-by-this-author ">Ashfaq Shuaib</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 51 / <a href="/core/product/F57E593421E8311D827E95C9D0E8646B" class="productParent" data-prod-id="F57E593421E8311D827E95C9D0E8646B">Issue 2</a> / March 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 29 March 2023</span><span class="pages">, pp. 226-232</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-9A18B6326F61CA073DA9BE5D0E6855CB" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/9A18B6326F61CA073DA9BE5D0E6855CB/S0317167123000367a.pdf/direct_to_angiosuite_in_acute_stroke_with_mobile_stroke_unit.pdf" data-pdf-content-id="9A18B6326F61CA073DA9BE5D0E6855CB" target="_blank" aria-label="Download PDF for Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/9A18B6326F61CA073DA9BE5D0E6855CB/core-reader" target="_blank" aria-label="View HTML full text for Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"9A18B6326F61CA073DA9BE5D0E6855CB","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="9A18B6326F61CA073DA9BE5D0E6855CB" data-container="representation" aria-label="Export citation for Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167123000367')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"9A18B6326F61CA073DA9BE5D0E6855CB"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167123000367" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Early reperfusion has the best likelihood for a favorable outcome in acute ischemic stroke (AIS) with large vessel occlusion (LVO). Our experience with mobile stroke unit (MSU) for direct to angiosuite (DTAS) transfer in AIS patients with suspected LVO is presented.</p></div><div class='sec'><span class="bold">Methods:</span><p>Retrospective review of prospectively collected data from November 2019 to August 2022, of patients evaluated and transferred by the University of Alberta Hospital MSU and moved to angiosuite for endovascular thrombectomy (EVT).</p></div><div class='sec'><span class="bold">Result:</span><p>A total of 41 cases were included. Nine were chosen for DTAS and 32 were shifted to angiosuite after stopping for computed tomography (CT) angiography of the head and neck (no-DTAS). Stroke severity measured by NIHSS (median with interquartile range (IQR)) was higher in patients of DTAS, 22 (14–24) vs 14.5 (5–25) in no-DTAS (<span class='italic'>p</span> = 0.001). The non-contrast CT head in MSU showed hyperdense vessels in 8 (88.88%) DTAS vs 11 (34.35%) no-DTAS patients (<span class='italic'>p</span> = 0.003). The EVT timelines (median with IQR, 90<span class='sup'>th</span> percentile) including “door to artery puncture time” were 31 (23–50, 49.2) vs 79 (39–264, 112.8) minutes, and “door to recanalization time” was 69 (49–110, 93.2) vs 105.5 (52–178, 159.5) minutes in DTAS vs no-DTAS group, respectively. The workflow times were significantly shorter in the DTAS group (<span class='italic'>p</span> < 0.001). Eight (88.88%) out of 9 DTAS patients had LVO and underwent thrombectomy.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>MSU for DTAS in patients with high NIHSS scores, cortical signs, and CT showing hyperdense vessel is an effective strategy to reduce the EVT workflow time.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2023.36" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2023.36" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="02F3C65FF680627DD4D59DA709007D61" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"02F3C65FF680627DD4D59DA709007D61","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="02F3C65FF680627DD4D59DA709007D61" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="815991" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/neurological-involvement-in-hospitalized-children-with-sarscov2-infection-a-multinational-study/02F3C65FF680627DD4D59DA709007D61"> Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Carmen Yea&eventCode=SE-AU" class="more-by-this-author ">Carmen Yea</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michelle Barton&eventCode=SE-AU" class="more-by-this-author ">Michelle Barton</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ari Bitnun&eventCode=SE-AU" class="more-by-this-author ">Ari Bitnun</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Shaun K. 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Ann Yeh&eventCode=SE-AU" class="more-by-this-author ">E. Ann Yeh</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 51 / <a href="/core/product/B39A0B74BB628B59E4E688D43EB6F23D" class="productParent" data-prod-id="B39A0B74BB628B59E4E688D43EB6F23D">Issue 1</a> / 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 January 2023</span><span class="pages">, pp. 40-49</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-02F3C65FF680627DD4D59DA709007D61" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/02F3C65FF680627DD4D59DA709007D61/S031716712200347Xa.pdf/neurological_involvement_in_hospitalized_children_with_sarscov2_infection_a_multinational_study.pdf" data-pdf-content-id="02F3C65FF680627DD4D59DA709007D61" target="_blank" aria-label="Download PDF for Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/02F3C65FF680627DD4D59DA709007D61/core-reader" target="_blank" aria-label="View HTML full text for Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"02F3C65FF680627DD4D59DA709007D61","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="02F3C65FF680627DD4D59DA709007D61" data-container="representation" aria-label="Export citation for Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS031716712200347X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"02F3C65FF680627DD4D59DA709007D61"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS031716712200347X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background and Objectives:</span><p>Neurological involvement associated with SARS-CoV-2 infection is increasingly recognized. However, the specific characteristics and prevalence in pediatric patients remain unclear. The objective of this study was to describe the neurological involvement in a multinational cohort of hospitalized pediatric patients with SARS-CoV-2.</p></div><div class='sec'><span class="bold">Methods:</span><p>This was a multicenter observational study of children <18 years of age with confirmed SARS-CoV-2 infection or multisystemic inflammatory syndrome (MIS-C) and laboratory evidence of SARS-CoV-2 infection in children, admitted to 15 tertiary hospitals/healthcare centers in Canada, Costa Rica, and Iran February 2020–May 2021. Descriptive statistical analyses were performed and logistic regression was used to identify factors associated with neurological involvement.</p></div><div class='sec'><span class="bold">Results:</span><p>One-hundred forty-seven (21%) of 697 hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Headache (<span class='italic'>n</span> = 103), encephalopathy (<span class='italic'>n</span> = 28), and seizures (<span class='italic'>n</span> = 30) were the most reported. Neurological signs/symptoms were significantly associated with ICU admission (OR: 1.71, 95% CI: 1.15–2.55; <span class='italic'>p</span> = 0.008), satisfaction of MIS-C criteria (OR: 3.71, 95% CI: 2.46–5.59; <span class='italic'>p</span> < 0.001), fever during hospitalization (OR: 2.15, 95% CI: 1.46–3.15; <span class='italic'>p</span> < 0.001), and gastrointestinal involvement (OR: 2.31, 95% CI: 1.58–3.40; <span class='italic'>p</span> < 0.001). Non-headache neurological manifestations were significantly associated with ICU admission (OR: 1.92, 95% CI: 1.08–3.42; <span class='italic'>p</span> = 0.026), underlying neurological disorders (OR: 2.98, 95% CI: 1.49–5.97, <span class='italic'>p</span> = 0.002), and a history of fever prior to hospital admission (OR: 2.76, 95% CI: 1.58–4.82; <span class='italic'>p</span> < 0.001).</p></div><div class='sec'><span class="bold">Discussion:</span><p>In this study, approximately 21% of hospitalized children with SARS-CoV-2 infection had neurological signs/symptoms. Future studies should focus on pathogenesis and long-term outcomes in these children.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.347" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.347" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="1E0F45CF9DB3D647DACE8D96CE2336A5" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"1E0F45CF9DB3D647DACE8D96CE2336A5","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="1E0F45CF9DB3D647DACE8D96CE2336A5" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="490493" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/estimating-the-number-of-hospital-or-emergency-department-presentations-for-stroke-in-canada/1E0F45CF9DB3D647DACE8D96CE2336A5"> Estimating the Number of Hospital or Emergency Department Presentations for Stroke in Canada </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Jessalyn K. Holodinsky&eventCode=SE-AU" class="more-by-this-author ">Jessalyn K. Holodinsky</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Patrice Lindsay&eventCode=SE-AU" class="more-by-this-author ">Patrice Lindsay</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Amy Y. X. Yu&eventCode=SE-AU" class="more-by-this-author ">Amy Y. X. Yu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Aravind Ganesh&eventCode=SE-AU" class="more-by-this-author ">Aravind Ganesh</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Raed A. Joundi&eventCode=SE-AU" class="more-by-this-author ">Raed A. Joundi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael D. Hill&eventCode=SE-AU" class="more-by-this-author ">Michael D. Hill</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/6D1D86A784C83521E905A2E87554B9CD" class="productParent" data-prod-id="6D1D86A784C83521E905A2E87554B9CD">Issue 6</a> / November 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 20 December 2022</span><span class="pages">, pp. 820-825</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-1E0F45CF9DB3D647DACE8D96CE2336A5" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/1E0F45CF9DB3D647DACE8D96CE2336A5/S0317167122003389a.pdf/estimating_the_number_of_hospital_or_emergency_department_presentations_for_stroke_in_canada.pdf" data-pdf-content-id="1E0F45CF9DB3D647DACE8D96CE2336A5" target="_blank" aria-label="Download PDF for Estimating the Number of Hospital or Emergency Department Presentations for Stroke in Canada [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/1E0F45CF9DB3D647DACE8D96CE2336A5/core-reader" target="_blank" aria-label="View HTML full text for Estimating the Number of Hospital or Emergency Department Presentations for Stroke in Canada [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"1E0F45CF9DB3D647DACE8D96CE2336A5","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="1E0F45CF9DB3D647DACE8D96CE2336A5" data-container="representation" aria-label="Export citation for Estimating the Number of Hospital or Emergency Department Presentations for Stroke in Canada">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167122003389')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Estimating the Number of Hospital or Emergency Department Presentations for Stroke in Canada" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"1E0F45CF9DB3D647DACE8D96CE2336A5"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167122003389" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Although age-standardized stroke occurrence has been decreasing, the absolute number of stroke events globally, and in Canada, is increasing. Stroke surveillance is necessary for health services planning, informing research design, and public health messaging. We used administrative data to estimate the number of stroke events resulting in hospital or emergency department presentation across Canada in the 2017–18 fiscal year.</p></div><div class='sec'><span class="bold">Methods:</span><p>Hospitalization data were obtained from the Canadian Institute for Health Information (CIHI) Discharge Abstract Database and the Ministry of Health and Social Services in Quebec. Emergency department data were obtained from the CIHI National Ambulatory Care Reporting System (Alberta and Ontario). Stroke events were identified using ICD-10 coding. Data were linked into episodes of care to account for readmissions and interfacility transfers. Projections for emergency department visits for provinces/territories outside of Alberta and Ontario were generated based upon age and sex-standardized estimates from Alberta and Ontario.</p></div><div class='sec'><span class="bold">Results:</span><p>In the 2017–18 fiscal year, there were 108,707 stroke events resulting in hospital or emergency department presentation across the country. This was made up of 54,357 events resulting in hospital admission and 54,350 events resulting in only emergency department presentation. The events resulting in only emergency department presentation consisted of 25,941 events observed in Alberta and Ontario and a projection of 28,409 events across the rest of the country.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>We estimate a stroke event resulting in hospital or emergency department presentation occurs every 5 minutes in Canada.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.338" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.338" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="6F66FB43B0BD618F35F9B9AE1C4EB1E3" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"6F66FB43B0BD618F35F9B9AE1C4EB1E3","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="6F66FB43B0BD618F35F9B9AE1C4EB1E3" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="167809" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/safety-evaluation-of-primary-carotid-stenting-transcranial-doppler-and-mri/6F66FB43B0BD618F35F9B9AE1C4EB1E3"> Safety Evaluation of Primary Carotid Stenting: Transcranial Doppler and MRI </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=David M. Pelz&eventCode=SE-AU" class="more-by-this-author ">David M. Pelz</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Stephen P. Lownie&eventCode=SE-AU" class="more-by-this-author ">Stephen P. Lownie</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Urooj F. Iftikhar&eventCode=SE-AU" class="more-by-this-author ">Urooj F. Iftikhar</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Claudio Munoz&eventCode=SE-AU" class="more-by-this-author ">Claudio Munoz</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pablo Lopez-Ojeda&eventCode=SE-AU" class="more-by-this-author ">Pablo Lopez-Ojeda</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Reza Azarpazhooh&eventCode=SE-AU" class="more-by-this-author ">Reza Azarpazhooh</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/B6820CFFBCFB61795FE88F52335C9B8F" class="productParent" data-prod-id="B6820CFFBCFB61795FE88F52335C9B8F">Issue 5</a> / September 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 17 October 2022</span><span class="pages">, pp. 651-655</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-6F66FB43B0BD618F35F9B9AE1C4EB1E3" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/6F66FB43B0BD618F35F9B9AE1C4EB1E3/S0317167122003043a.pdf/safety_evaluation_of_primary_carotid_stenting_transcranial_doppler_and_mri.pdf" data-pdf-content-id="6F66FB43B0BD618F35F9B9AE1C4EB1E3" target="_blank" aria-label="Download PDF for Safety Evaluation of Primary Carotid Stenting: Transcranial Doppler and MRI [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/6F66FB43B0BD618F35F9B9AE1C4EB1E3/core-reader" target="_blank" aria-label="View HTML full text for Safety Evaluation of Primary Carotid Stenting: Transcranial Doppler and MRI [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"6F66FB43B0BD618F35F9B9AE1C4EB1E3","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="6F66FB43B0BD618F35F9B9AE1C4EB1E3" data-container="representation" aria-label="Export citation for Safety Evaluation of Primary Carotid Stenting: Transcranial Doppler and MRI">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167122003043')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Safety Evaluation of Primary Carotid Stenting: Transcranial Doppler and MRI" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"6F66FB43B0BD618F35F9B9AE1C4EB1E3"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167122003043" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background and Purpose:</span><p>Cerebral emboli are generated by every step of standard carotid angioplasty and stenting. Primary carotid stenting (PCS) is a technique in which the use of balloon angioplasty (BA) is minimized to decrease the embolic load. The primary aim of this study is to establish the number of emboli generated by each step of primary stenting and determine the relationship to new diffusion (DWI) lesions on subsequent magnetic resonance imaging (MRI).</p></div><div class='sec'><span class="bold">Methods:</span><p>Eighty-five patients with severe, symptomatic carotid stenosis were prospectively recruited and underwent carotid stenting. Intraoperative transcranial Doppler was performed in 77 patients. The number and size of microemboli for each of seven procedural steps were recorded. Correlation was made with the number and location of new DWI lesions.</p></div><div class='sec'><span class="bold">Results:</span><p>PCS was performed in 73 patients. BA was required in 12 patients. The mean number of microemboli was 114, and most microemboli were generated by stent deployment, followed by BA. Balloon techniques generated significantly more emboli than primary stenting (<span class='italic'>p</span> = 0.017). There was a significant relationship between total microemboli and new DWI lesions (<span class='italic'>p</span> = 0.009), and between new DWI lesions in multiple territories and the severity of pretreatment stenosis (<span class='italic'>p</span> = 0.002).</p></div><div class='sec'><span class="bold">Conclusions:</span><p>During PCS, more emboli are generated by stent deployment than during any other stage of the procedure. When BA is necessary, more malignant emboli are generated but total emboli are unchanged and there is no difference in new diffusion lesions on MRI. PCS is safe and is not inferior to historical controls for the generation of new DWI lesions.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.304" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.304" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Review Article</h4> <div class="representation overview search" data-prod-id="66ECF1B8866038DDA42DBED3B91352B2" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"66ECF1B8866038DDA42DBED3B91352B2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="66ECF1B8866038DDA42DBED3B91352B2" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="402105" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/timing-of-anticoagulation-after-acute-ischemic-stroke-in-patients-with-atrial-fibrillation/66ECF1B8866038DDA42DBED3B91352B2"> Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Anas Alrohimi&eventCode=SE-AU" class="more-by-this-author ">Anas Alrohimi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Glen Jickling&eventCode=SE-AU" class="more-by-this-author ">Glen Jickling</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian Buck&eventCode=SE-AU" class="more-by-this-author ">Brian Buck</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ken S. Butcher&eventCode=SE-AU" class="more-by-this-author ">Ken S. Butcher</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/B1D0726ADFAEA7351E137CFD167845BA" class="productParent" data-prod-id="B1D0726ADFAEA7351E137CFD167845BA">Issue 4</a> / July 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 28 June 2022</span><span class="pages">, pp. 503-514</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-66ECF1B8866038DDA42DBED3B91352B2" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/66ECF1B8866038DDA42DBED3B91352B2/S0317167122002682a.pdf/timing_of_anticoagulation_after_acute_ischemic_stroke_in_patients_with_atrial_fibrillation.pdf" data-pdf-content-id="66ECF1B8866038DDA42DBED3B91352B2" target="_blank" aria-label="Download PDF for Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/66ECF1B8866038DDA42DBED3B91352B2/core-reader" target="_blank" aria-label="View HTML full text for Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"66ECF1B8866038DDA42DBED3B91352B2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="66ECF1B8866038DDA42DBED3B91352B2" data-container="representation" aria-label="Export citation for Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167122002682')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"66ECF1B8866038DDA42DBED3B91352B2"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167122002682" class="content"> <div class="abstract" data-abstract-type="normal"> <p>Patients with atrial fibrillation (AF) and ischemic stroke are at high risk for stroke recurrence. Early anticoagulation may reduce the risk of recurrent events but is usually avoided due to the risk of hemorrhagic transformation (HT). Current guidelines are based on empiric expert opinion. The assumed risk of HT is based on historical data from an older generation of anticoagulants. The direct oral anticoagulants (DOACs) have demonstrated lower risk of intracranial hemorrhage compared to older anticoagulants. However, the optimal timing of DOAC initiation after AF-related ischemic stroke has remained an area of clinical equipoise, as the pivotal phase III trials did not include patients in the early period after ischemic stroke. Multiple prospective studies and a few smaller randomized controlled trials evaluating the safety and efficacy of early versus delayed DOAC initiation have been completed. These studies have reported promising results of early DOAC initiation after acute ischemic stroke. However, a standardized documentation of HT rates on follow-up imaging with objective assessment criteria is missing from most of these studies. Larger randomized trials of early versus delayed DOAC are ongoing. A literature review was performed using keywords and Medical Subject Headings in MEDLINE/PubMed and Google Scholar databases. For each relevant paper, the bibliography was scrutinized for other relevant articles and journals. In this article, we review the risk of recurrent ischemic stroke and HT in patients with AF, pathophysiology, classification, predictors, natural history, and outcomes of HT and discuss the studies of early anticoagulation after AF-related ischemic stroke.</p> </div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.268" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.268" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="E29225CE8E66BE3D3EE7CBA920106DAB" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"E29225CE8E66BE3D3EE7CBA920106DAB","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="E29225CE8E66BE3D3EE7CBA920106DAB" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="984257" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/current-concepts-of-mixed-pathologies-in-neurodegenerative-diseases/E29225CE8E66BE3D3EE7CBA920106DAB"> Current Concepts of Mixed Pathologies in Neurodegenerative Diseases </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Shelley L. Forrest&eventCode=SE-AU" class="more-by-this-author ">Shelley L. Forrest</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Gabor G. Kovacs&eventCode=SE-AU" class="more-by-this-author ">Gabor G. Kovacs</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/49DF66B37545EEFFEAB4B9CD30456158" class="productParent" data-prod-id="49DF66B37545EEFFEAB4B9CD30456158">Issue 3</a> / May 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 31 March 2022</span><span class="pages">, pp. 329-345</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-E29225CE8E66BE3D3EE7CBA920106DAB" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/E29225CE8E66BE3D3EE7CBA920106DAB/S0317167122000348a.pdf/current_concepts_of_mixed_pathologies_in_neurodegenerative_diseases.pdf" data-pdf-content-id="E29225CE8E66BE3D3EE7CBA920106DAB" target="_blank" aria-label="Download PDF for Current Concepts of Mixed Pathologies in Neurodegenerative Diseases [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/E29225CE8E66BE3D3EE7CBA920106DAB/core-reader" target="_blank" aria-label="View HTML full text for Current Concepts of Mixed Pathologies in Neurodegenerative Diseases [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"E29225CE8E66BE3D3EE7CBA920106DAB","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="E29225CE8E66BE3D3EE7CBA920106DAB" data-container="representation" aria-label="Export citation for Current Concepts of Mixed Pathologies in Neurodegenerative Diseases">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167122000348')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Current Concepts of Mixed Pathologies in Neurodegenerative Diseases" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"E29225CE8E66BE3D3EE7CBA920106DAB"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167122000348" class="content"> <div class="abstract" data-abstract-type="normal"> <p>Neurodegenerative diseases are a pathologically, clinically and genetically diverse group of disorders without effective disease-modifying therapies. Pathologically, these disorders are characterised by disease-specific protein aggregates in neurons and/or glia and referred to as proteinopathies. Many neurodegenerative diseases show pathological overlap with the same abnormally deposited protein occurring in anatomically distinct regions, which give rise to specific patterns of cognitive and motor clinical phenotypes. Sequential distribution patterns of protein inclusions throughout the brain have been described. Rather than occurring in isolation, it is increasingly recognised that combinations of one or more proteinopathies with or without cerebrovascular disease frequently occur in individuals with neurodegenerative diseases. In addition, complex constellations of ageing-related and incidental pathologies associated with tau, TDP-43, Aβ, α-synuclein deposition have been commonly reported in longitudinal ageing studies. This review provides an overview of current classification of neurodegenerative and age-related pathologies and presents the spectrum and complexity of mixed pathologies in community-based, longitudinal ageing studies, in major proteinopathies, and genetic conditions. Mixed pathologies are commonly reported in individuals >65 years with and without cognitive impairment; however, they are increasingly recognised in younger individuals (<65 years). Mixed pathologies are thought to lower the threshold for developing cognitive impairment and dementia. Hereditary neurodegenerative diseases also show a diverse range of mixed pathologies beyond the proteinopathy primarily linked to the genetic abnormality. Cases with mixed pathologies might show a different clinical course, which has prognostic relevance and obvious implications for biomarker and therapy development, and stratifying patients for clinical trials.</p> </div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.34" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2022.34" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Original Article</h4> <div class="representation overview search" data-prod-id="08FD76BBDFF3B826C60042F8DC358DAE" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"08FD76BBDFF3B826C60042F8DC358DAE","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="08FD76BBDFF3B826C60042F8DC358DAE" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="175616" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/acute-traumatic-subdural-hematoma-and-anticoagulation-risk/08FD76BBDFF3B826C60042F8DC358DAE"> Acute Traumatic Subdural Hematoma and Anticoagulation Risk </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Maryam Kia&eventCode=SE-AU" class="more-by-this-author ">Maryam Kia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rajeet Singh Saluja&eventCode=SE-AU" class="more-by-this-author ">Rajeet Singh Saluja</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Judith Marcoux&eventCode=SE-AU" class="more-by-this-author ">Judith Marcoux</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/ED59853F20AAF664F573F8149E56AA01" class="productParent" data-prod-id="ED59853F20AAF664F573F8149E56AA01">Issue 2</a> / March 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 03 January 2022</span><span class="pages">, pp. 188-193</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-08FD76BBDFF3B826C60042F8DC358DAE" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/08FD76BBDFF3B826C60042F8DC358DAE/S0317167121005187a.pdf/acute_traumatic_subdural_hematoma_and_anticoagulation_risk.pdf" data-pdf-content-id="08FD76BBDFF3B826C60042F8DC358DAE" target="_blank" aria-label="Download PDF for Acute Traumatic Subdural Hematoma and Anticoagulation Risk [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/08FD76BBDFF3B826C60042F8DC358DAE/core-reader" target="_blank" aria-label="View HTML full text for Acute Traumatic Subdural Hematoma and Anticoagulation Risk [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"08FD76BBDFF3B826C60042F8DC358DAE","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span 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<button onclick="toggleViewHide(this, 'abstractS0317167121005187')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Acute Traumatic Subdural Hematoma and Anticoagulation Risk" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"08FD76BBDFF3B826C60042F8DC358DAE"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121005187" class="content"> <div class="abstract" data-abstract-type="normal"> <div class='sec'> <span class="bold">Background:</span> <p>Anticoagulation is used to prevent thromboembolic events. It is a common practice to hold anticoagulation in the first few days following a traumatic brain injury (TBI) with intracranial hemorrhage. However, traumatic subdural hematomas (SDH) are prone to re-hemorrhage long after the trauma. Data are scarce in the literature on the best timing to resume anticoagulation following a TBI.</p> </div> <div class='sec'> <span class="bold">Methods:</span> <p>Review of 95 consecutive patients admitted to a level 1 trauma center with a diagnosis of traumatic SDH and requiring anticoagulation. The reasons for anticoagulation, the amount of time without anticoagulation, CT characteristics, and the incidence of thromboembolic events or SDH re-hemorrhage were collected.</p> </div> <div class='sec'> <span class="bold">Results:</span> <p>41.3% used anticoagulation for coronary artery disease and peripheral vascular disease, 24% for atrial fibrillation, 12% for cardiac valve replacement, and 12% for venous thromboembolic events. Anticoagulation was held a median of 67 days. For most patients (82.1%), anticoagulation was re-introduced once the SDH had completely resolved. For 17.9%, anticoagulation was restarted while the SDH had not completely resolved. One (1.1%) patient suffered from an atrial clot while anticoagulation was held. For those with residual SDH, 41.2% suffered from a SDH re-hemorrhage and 17.6% required surgery. The risk of re-hemorrhage climbed to 62.5% if the SDH remnant was large.</p> </div> <div class='sec'> <span class="bold">Conclusion:</span> <p>Anticoagulation while there is a residual SDH was associated with a significant risk of re-hemorrhage. This risk should be weighed against the risk of holding anticoagulation.</p> </div> </div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.518" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.518" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="F26C6DAE19F920794075859D10082AB1" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"F26C6DAE19F920794075859D10082AB1","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="F26C6DAE19F920794075859D10082AB1" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="429090" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/association-between-excess-sleep-duration-and-risk-of-stroke-a-populationbased-study/F26C6DAE19F920794075859D10082AB1"> Association Between Excess Sleep Duration and Risk of Stroke: A Population-Based Study </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Raed A. Joundi&eventCode=SE-AU" class="more-by-this-author ">Raed A. Joundi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Scott B. Patten&eventCode=SE-AU" class="more-by-this-author ">Scott B. Patten</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jeanne V.A. Williams&eventCode=SE-AU" class="more-by-this-author ">Jeanne V.A. Williams</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Eric E. Smith&eventCode=SE-AU" class="more-by-this-author ">Eric E. Smith</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 50 / <a href="/core/product/CF63E659BE79CAA55AD3BDA720EEB698" class="productParent" data-prod-id="CF63E659BE79CAA55AD3BDA720EEB698">Issue 1</a> / January 2023 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 21 October 2021</span><span class="pages">, pp. 17-22</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-F26C6DAE19F920794075859D10082AB1" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/F26C6DAE19F920794075859D10082AB1/S0317167121002420a.pdf/association_between_excess_sleep_duration_and_risk_of_stroke_a_populationbased_study.pdf" data-pdf-content-id="F26C6DAE19F920794075859D10082AB1" target="_blank" aria-label="Download PDF for Association Between Excess Sleep Duration and Risk of Stroke: A Population-Based Study [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/F26C6DAE19F920794075859D10082AB1/core-reader" target="_blank" aria-label="View HTML full text for Association Between Excess Sleep Duration and Risk of Stroke: A Population-Based Study [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"F26C6DAE19F920794075859D10082AB1","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); 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We linked to hospital records to determine subsequent admissions or emergency department visits for acute stroke until December 31, 2017. We used Cox proportional hazard models to determine the association between sleep duration and risk of stroke, assessing for modification by age and sex and adjusting for demographic, vascular, and social factors. We obtained cumulative incidence of stroke accounting for the competing risk of death.</p></div><div class='sec'><span class="bold">Results:</span><p>There were 82,795 individuals in our cohort who met inclusion criteria and had self-reported sleep duration, with 1705 stroke events in follow-up. There was an association between excess sleep (≥10 h/night) and risk of stroke in those <70 years (fully adjusted hazard ratio 2.29, 95% CI 1.04–5.06), but not ≥70 years of age, with a similar association after accounting for the competing risk of death.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Sleep duration ≥10 h/night is associated with increased risk of stroke in those <70 years of age. The findings support current guidelines for 7–9 h of sleep per night. Further research is needed to elucidate the relationship between sleep and cerebrovascular disease.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.242" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.242" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="6158117EDF7E4704BC501A21D3022B41" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"6158117EDF7E4704BC501A21D3022B41","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="6158117EDF7E4704BC501A21D3022B41" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="782271" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/determinants-of-leptomeningeal-collateral-status-variability-in-ischemic-stroke-patients/6158117EDF7E4704BC501A21D3022B41"> Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Alexander D. Rebchuk&eventCode=SE-AU" class="more-by-this-author ">Alexander D. Rebchuk</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Thalia S. Field&eventCode=SE-AU" class="more-by-this-author ">Thalia S. Field</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael D. Hill&eventCode=SE-AU" class="more-by-this-author ">Michael D. Hill</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mayank Goyal&eventCode=SE-AU" class="more-by-this-author ">Mayank Goyal</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Andrew Demchuk&eventCode=SE-AU" class="more-by-this-author ">Andrew Demchuk</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jessalyn K. Holodinsky&eventCode=SE-AU" class="more-by-this-author ">Jessalyn K. 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Menon</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/8844BAA07FE99DC562028278BE92A720" class="productParent" data-prod-id="8844BAA07FE99DC562028278BE92A720">Issue 6</a> / November 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 29 September 2021</span><span class="pages">, pp. 767-773</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-6158117EDF7E4704BC501A21D3022B41" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/6158117EDF7E4704BC501A21D3022B41/S0317167121002262a.pdf/determinants_of_leptomeningeal_collateral_status_variability_in_ischemic_stroke_patients.pdf" data-pdf-content-id="6158117EDF7E4704BC501A21D3022B41" target="_blank" aria-label="Download PDF for Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/6158117EDF7E4704BC501A21D3022B41/core-reader" target="_blank" aria-label="View HTML full text for Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"6158117EDF7E4704BC501A21D3022B41","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="6158117EDF7E4704BC501A21D3022B41" data-container="representation" aria-label="Export citation for Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121002262')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"6158117EDF7E4704BC501A21D3022B41"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121002262" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Collateral status is an indicator of a favorable outcome in stroke. Leptomeningeal collaterals provide alternative routes for brain perfusion following an arterial occlusion or flow-limiting stenosis. Using a large cohort of ischemic stroke patients, we examined the relative contribution of various demographic, laboratory, and clinical variables in explaining variability in collateral status.</p></div><div class='sec'><span class="bold">Methods:</span><p>Patients with acute ischemic stroke in the anterior circulation were enrolled in a multi-center hospital-based observational study. Intracranial occlusions and collateral status were identified and graded using multiphase computed tomography angiography. Based on the percentage of affected territory filled by collateral supply, collaterals were graded as either poor (0–49%), good (50–99%), or optimal (100%). Between-group differences in demographic, laboratory, and clinical factors were explored using ordinal regression models. Further, we explored the contribution of measured variables in explaining variance in collateral status.</p></div><div class='sec'><span class="bold">Results:</span><p>386 patients with collateral status classified as poor (<span class='italic'>n</span> = 64), good (<span class='italic'>n</span> = 125), and optimal (<span class='italic'>n</span> = 197) were included. Median time from symptom onset to CT was 120 (IQR: 78–246) minutes. In final multivariable model, male sex (OR 1.9, 95% CIs [1.2, 2.9], <span class='italic'>p</span> = 0.005) and leukocytosis (OR 1.1, 95% CIs [1.1, 1.2], <span class='italic'>p</span> = 0.001) were associated with poor collaterals. Measured variables only explained 44.8–53.0% of the observed between-patient variance in collaterals.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Male sex and leukocytosis are associated with poorer collaterals. Nearly half of the variance in collateral flow remains unexplained and could be in part due to genetic differences.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.226" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.226" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="F8E6DFD9C08AAFE1F7A96C3C5039555E" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"F8E6DFD9C08AAFE1F7A96C3C5039555E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="F8E6DFD9C08AAFE1F7A96C3C5039555E" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="242614" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/return-on-investment-in-endovascular-care-the-case-of-endovascular-reperfusion-alberta/F8E6DFD9C08AAFE1F7A96C3C5039555E"> Return on Investment in Endovascular Care: The Case of Endovascular Reperfusion Alberta </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Nguyen Xuan Thanh&eventCode=SE-AU" class="more-by-this-author ">Nguyen Xuan Thanh</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Thomas Jeerakathil&eventCode=SE-AU" class="more-by-this-author ">Thomas Jeerakathil</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jillian Stang&eventCode=SE-AU" class="more-by-this-author ">Jillian Stang</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mary-Lou Halabi&eventCode=SE-AU" class="more-by-this-author ">Mary-Lou Halabi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Balraj Mann&eventCode=SE-AU" class="more-by-this-author ">Balraj Mann</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian H. 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Hill</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/BAC01E0307F869991634CF0CB75757B9" class="productParent" data-prod-id="BAC01E0307F869991634CF0CB75757B9">Issue 5</a> / 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 06 August 2021</span><span class="pages">, pp. 629-635</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-F8E6DFD9C08AAFE1F7A96C3C5039555E" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/F8E6DFD9C08AAFE1F7A96C3C5039555E/S031716712100189Xa.pdf/return_on_investment_in_endovascular_care_the_case_of_endovascular_reperfusion_alberta.pdf" data-pdf-content-id="F8E6DFD9C08AAFE1F7A96C3C5039555E" target="_blank" aria-label="Download PDF for Return on Investment in Endovascular Care: The Case of Endovascular Reperfusion Alberta [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/F8E6DFD9C08AAFE1F7A96C3C5039555E/core-reader" target="_blank" aria-label="View HTML full text for Return on Investment in Endovascular Care: The Case of Endovascular Reperfusion Alberta [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"F8E6DFD9C08AAFE1F7A96C3C5039555E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="F8E6DFD9C08AAFE1F7A96C3C5039555E" data-container="representation" aria-label="Export citation for Return on Investment in Endovascular Care: The Case of Endovascular Reperfusion Alberta">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS031716712100189X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Return on Investment in Endovascular Care: The Case of Endovascular Reperfusion Alberta" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"F8E6DFD9C08AAFE1F7A96C3C5039555E"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS031716712100189X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objective:</span><p>We examined the return on investment (ROI) from the Endovascular Reperfusion Alberta (ERA) project, a provincially funded population-wide strategy to improve access to endovascular therapy (EVT), to inform policy regarding sustainability.</p></div><div class='sec'><span class="bold">Methods:</span><p>We calculated net benefit (NB) as benefit minus cost and ROI as benefit divided by cost. Patients treated with EVT and their controls were identified from the ESCAPE trial. Using the provincial administrative databases, their health services utilization (HSU), including inpatient, outpatient, physician, long-term care services, and prescription drugs, were compared. This benefit was then extrapolated to the number of patients receiving EVT increased in 2018 and 2019 by the ERA implementation. We used three time horizons, including short (90 days), medium (1 year), and long-term (5 years).</p></div><div class='sec'><span class="bold">Results:</span><p>EVT was associated with a reduced gross HSU cost for all the three time horizons. Given the total costs of ERA were $2.04 million in 2018 ($11,860/patient) and $3.73 million in 2019 ($17,070/patient), NB per patient in 2018 (2019) was estimated at −$7,313 (−$12,524), $54,592 ($49,381), and $47,070 ($41,859) for short, medium, and long-term time horizons, respectively. Total NB for the province in 2018 (2019) were −$1.26 (−$2.74), $9.40 ($10.78), and $8.11 ($9.14) million; ROI ratios were 0.4 (0.3), 5.6 (3.9) and 5.0 (3.5). Probabilities of ERA being cost saving were 39% (31%), 97% (96%), and 94% (91%), for short, medium, and long-term time horizons, respectively.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>The ERA program was cost saving in the medium and long-term time horizons. Results emphasized the importance of considering a broad range of HSU and long-term impact to capture the full ROI.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.189" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.189" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="C675476CB3C7798F73269CA4B4D07995" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"C675476CB3C7798F73269CA4B4D07995","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="C675476CB3C7798F73269CA4B4D07995" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="161465" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/treatment-with-highdose-prednisolone-in-vigabatrinrefractory-infantile-spasms/C675476CB3C7798F73269CA4B4D07995"> Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Wafaa Al-Shehhi&eventCode=SE-AU" class="more-by-this-author ">Wafaa Al-Shehhi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vann Chau&eventCode=SE-AU" class="more-by-this-author ">Vann Chau</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jennifer Boyd&eventCode=SE-AU" class="more-by-this-author ">Jennifer Boyd</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Carter Snead&eventCode=SE-AU" class="more-by-this-author ">Carter Snead</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rohit Sharma&eventCode=SE-AU" class="more-by-this-author ">Rohit Sharma</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Elizabeth Donner&eventCode=SE-AU" class="more-by-this-author ">Elizabeth Donner</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Cristina Go&eventCode=SE-AU" class="more-by-this-author ">Cristina Go</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Puneet Jain&eventCode=SE-AU" class="more-by-this-author ">Puneet Jain</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/561C4A3B0E04561D2468C933FD527FE8" class="productParent" data-prod-id="561C4A3B0E04561D2468C933FD527FE8">Issue 4</a> / 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 02 July 2021</span><span class="pages">, pp. 532-539</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-C675476CB3C7798F73269CA4B4D07995" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/C675476CB3C7798F73269CA4B4D07995/S0317167121001566a.pdf/treatment_with_highdose_prednisolone_in_vigabatrinrefractory_infantile_spasms.pdf" data-pdf-content-id="C675476CB3C7798F73269CA4B4D07995" target="_blank" aria-label="Download PDF for Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/C675476CB3C7798F73269CA4B4D07995/core-reader" target="_blank" aria-label="View HTML full text for Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"C675476CB3C7798F73269CA4B4D07995","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the 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for Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"C675476CB3C7798F73269CA4B4D07995"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121001566" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objectives:</span><p>This research aimed to study the short-term seizure outcomes following treatment with 8 mg/kg/day prednisolone in children with infantile spasms (IS) refractory to vigabatrin. We hypothesized that high-dose prednisolone may result in similar rates of electroclinical remission when compared to published ACTH rates.</p></div><div class='sec'><span class="bold">Methods:</span><p>All consecutive children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without IS, who had been treated with vigabatrin as first-line anti-seizure medication (ASM) followed by high-dose oral prednisolone (8 mg/kg/day; maximum 60 mg/day) in cases who did not respond to vigabatrin, were included. Clinical and electroclinical response (ECR) at 2 weeks following initiation of treatment and adverse effects were assessed.</p></div><div class='sec'><span class="bold">Results:</span><p>Sixty-five children were included. A genetic etiology was seen in 38.5% cases. Complete ECR was seen in 30.8% (20/65) of the patients 2 weeks after vigabatrin. Complete ECR was noted in 77.8% (35/45) of the patients, 2 weeks after prednisolone initiation in children who failed vigabatrin, and this was sustained at 6 weeks in 66.7% (30/45) patients. Prednisolone was generally well tolerated.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>High-dose (8 mg/kg/day) oral prednisolone resulted in sustained complete ECR (at 6 weeks) in two-thirds of the children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without parentally reported IS. It was generally well tolerated and found to be safe.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.156" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.156" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="92C9537D3ACCCBAB1E940FB201AEDCF2" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"92C9537D3ACCCBAB1E940FB201AEDCF2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="92C9537D3ACCCBAB1E940FB201AEDCF2" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="179149" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/recognition-of-psychogenic-versus-epileptic-seizures-based-on-videos/92C9537D3ACCCBAB1E940FB201AEDCF2"> Recognition of Psychogenic Versus Epileptic Seizures Based on Videos </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Veronica Birca&eventCode=SE-AU" class="more-by-this-author ">Veronica Birca</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mark R. Keezer&eventCode=SE-AU" class="more-by-this-author ">Mark R. Keezer</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Laury Chamelian&eventCode=SE-AU" class="more-by-this-author ">Laury Chamelian</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Anne Lortie&eventCode=SE-AU" class="more-by-this-author ">Anne Lortie</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dang K. Nguyen&eventCode=SE-AU" class="more-by-this-author ">Dang K. Nguyen</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/9464D1CE53858B2D79E464BC64024702" class="productParent" data-prod-id="9464D1CE53858B2D79E464BC64024702">Issue 3</a> / May 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 21 June 2021</span><span class="pages">, pp. 352-360</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-92C9537D3ACCCBAB1E940FB201AEDCF2" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/92C9537D3ACCCBAB1E940FB201AEDCF2/S0317167121001438a.pdf/recognition_of_psychogenic_versus_epileptic_seizures_based_on_videos.pdf" data-pdf-content-id="92C9537D3ACCCBAB1E940FB201AEDCF2" target="_blank" aria-label="Download PDF for Recognition of Psychogenic Versus Epileptic Seizures Based on Videos [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/92C9537D3ACCCBAB1E940FB201AEDCF2/core-reader" target="_blank" aria-label="View HTML full text for Recognition of Psychogenic Versus Epileptic Seizures Based on Videos [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"92C9537D3ACCCBAB1E940FB201AEDCF2","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="92C9537D3ACCCBAB1E940FB201AEDCF2" data-container="representation" aria-label="Export citation for Recognition of Psychogenic Versus Epileptic Seizures Based on Videos">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121001438')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Recognition of Psychogenic Versus Epileptic Seizures Based on Videos" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"92C9537D3ACCCBAB1E940FB201AEDCF2"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121001438" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objective:</span><p>Ictal semiology interpretation for differentiating psychogenic nonepileptic seizures (PNESs) and epileptic seizures (ESs) is important for the institution of appropriate treatment. Our objective was to assess the ability of different health care professionals (HCPs) or students to distinguish PNES from ES based on video-recorded seizure semiology.</p></div><div class='sec'><span class="bold">Methods:</span><p>This study was designed following the Standards for Reporting of Diagnostic Accuracy Studies (STARD) guidelines. We showed in a random mix 36 videos of PNES or ES (18 each) and asked 558 participants to classify each seizure. The diagnostic accuracy of various groups of HCPs or students for PNES versus ES was assessed, as well as the effect of patient age and sex. Measures of diagnostic accuracy included sensitivity, specificity, and area under the curve (AUC).</p></div><div class='sec'><span class="bold">Results:</span><p>The descending order of diagnostic accuracy (AUC) was the following (p ≤ 0.001): (1) neurologists and epileptologists; (2) neurology residents; (3) other specialists and nurses with experience in epilepsy; and (4) undergraduate medical students. Although there was a strong trend toward statistical difference, with AUC 95% confidence intervals (CIs) that were not overlapping, between epileptologists (95% CI 93, 97) compared to neurologists (95% CI 88, 91), and neurologists compared to electroencephalography technicians (95% CI 82, 87), multiple pairwise comparisons with the conservative Tukey–Kramer honest significant difference test revealed no statistical difference (p = 0.25 and 0.1, respectively). Patient age and sex did not have an effect on diagnostic accuracy in neurology specialists.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Visual recognition of PNES by HCPs or students varies overall proportionately with the level of expertise in the field of neurology/epilepsy.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.143" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.143" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="EE7594194B5B70C06A7E3E1D1D43654B" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"EE7594194B5B70C06A7E3E1D1D43654B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="EE7594194B5B70C06A7E3E1D1D43654B" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="237669" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/use-of-alzheimers-disease-cerebrospinal-fluid-biomarkers-in-a-tertiary-care-memory-clinic/EE7594194B5B70C06A7E3E1D1D43654B"> Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Michael Stiffel&eventCode=SE-AU" class="more-by-this-author ">Michael Stiffel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=David Bergeron&eventCode=SE-AU" class="more-by-this-author ">David Bergeron</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Karim Mourabit Amari&eventCode=SE-AU" class="more-by-this-author ">Karim Mourabit Amari</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Élizabeth Poulin&eventCode=SE-AU" class="more-by-this-author ">Élizabeth Poulin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Xavier Roberge&eventCode=SE-AU" class="more-by-this-author ">Xavier Roberge</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Synthia Meilleur-Durand&eventCode=SE-AU" class="more-by-this-author ">Synthia Meilleur-Durand</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Leila Sellami&eventCode=SE-AU" class="more-by-this-author ">Leila Sellami</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pierre Molin&eventCode=SE-AU" class="more-by-this-author ">Pierre Molin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yannick Nadeau&eventCode=SE-AU" class="more-by-this-author ">Yannick Nadeau</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Marie-Pierre Fortin&eventCode=SE-AU" class="more-by-this-author ">Marie-Pierre Fortin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Stéphanie Caron&eventCode=SE-AU" class="more-by-this-author ">Stéphanie Caron</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Stéphane Poulin&eventCode=SE-AU" class="more-by-this-author ">Stéphane Poulin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Louis Verret&eventCode=SE-AU" class="more-by-this-author ">Louis Verret</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rémi W. Bouchard&eventCode=SE-AU" class="more-by-this-author ">Rémi W. Bouchard</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Charlotte Teunissen&eventCode=SE-AU" class="more-by-this-author ">Charlotte Teunissen</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Robert Jr Laforce&eventCode=SE-AU" class="more-by-this-author ">Robert Jr Laforce</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/16BB3AEBD526738C1A017DE76ACB7634" class="productParent" data-prod-id="16BB3AEBD526738C1A017DE76ACB7634">Issue 2</a> / March 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 13 April 2021</span><span class="pages">, pp. 203-209</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-EE7594194B5B70C06A7E3E1D1D43654B" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/EE7594194B5B70C06A7E3E1D1D43654B/S0317167121000676a.pdf/use_of_alzheimers_disease_cerebrospinal_fluid_biomarkers_in_a_tertiary_care_memory_clinic.pdf" data-pdf-content-id="EE7594194B5B70C06A7E3E1D1D43654B" target="_blank" aria-label="Download PDF for Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/EE7594194B5B70C06A7E3E1D1D43654B/core-reader" target="_blank" aria-label="View HTML full text for Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"EE7594194B5B70C06A7E3E1D1D43654B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="EE7594194B5B70C06A7E3E1D1D43654B" data-container="representation" aria-label="Export citation for Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000676')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Use of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"EE7594194B5B70C06A7E3E1D1D43654B"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000676" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction:</span><p>Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers are promising tools to help identify the underlying pathology of neurocognitive disorders. In this manuscript, we report our experience with AD CSF biomarkers in 262 consecutive patients in a tertiary care memory clinic.</p></div><div class='sec'><span class="bold">Methods:</span><p>We retrospectively reviewed 262 consecutive patients who underwent lumbar puncture (LP) and CSF measurement of AD biomarkers (Aβ1–42, total tau or t-tau, and p-tau181). We studied the safety of the procedure and its impact on patient’s diagnosis and management.</p></div><div class='sec'><span class="bold">Results:</span><p>The LP allowed to identify underlying AD pathology in 72 of the 121 patients (59%) with early onset amnestic mild cognitive impairment (aMCI) with a high probability of progression to AD; to distinguish the behavioral/dysexecutive variant of AD from the behavioral variant of frontotemporal dementia (bvFTD) in 25 of the 45 patients (55%) with an atypical neurobehavioral profile; to identify AD as the underlying pathology in 15 of the 27 patients (55%) with atypical or unclassifiable primary progressive aphasia (PPA); and to distinguish AD from other disorders in 9 of the 29 patients (31%) with psychiatric differential diagnoses and 19 of the 40 patients (47%) with lesional differential diagnoses (normal pressure hydrocephalus, encephalitis, prion disease, etc.). No major complications occurred following the LP.</p></div><div class='sec'><span class="bold">Interpretation:</span><p>Our results suggest that CSF analysis is a safe and effective diagnostic tool in select patients with neurocognitive disorders. We advocate for a wider use of this biomarker in tertiary care memory clinics in Canada.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.67" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.67" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="21E1A21A4C1E603C7F6210551C58A028" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" 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class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Laurent Derex&eventCode=SE-AU" class="more-by-this-author ">Laurent Derex</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Julie Haesebaert&eventCode=SE-AU" class="more-by-this-author ">Julie Haesebaert</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Céline Odier&eventCode=SE-AU" class="more-by-this-author ">Céline Odier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Walid Alesefir&eventCode=SE-AU" class="more-by-this-author ">Walid Alesefir</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yves Berthezène&eventCode=SE-AU" class="more-by-this-author ">Yves Berthezène</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Marielle Buisson&eventCode=SE-AU" class="more-by-this-author ">Marielle Buisson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Nicole Daneault&eventCode=SE-AU" class="more-by-this-author ">Nicole Daneault</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yan Deschaintre&eventCode=SE-AU" class="more-by-this-author ">Yan Deschaintre</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Omer Faruk Eker&eventCode=SE-AU" class="more-by-this-author ">Omer Faruk Eker</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Laura Gioia&eventCode=SE-AU" class="more-by-this-author ">Laura Gioia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dana Iancu&eventCode=SE-AU" class="more-by-this-author ">Dana Iancu</a><span class="separator">, </span><a 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href="/core/search?filters%5BauthorTerms%5D=Christian Stapf&eventCode=SE-AU" class="more-by-this-author ">Christian Stapf</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alain Weill&eventCode=SE-AU" class="more-by-this-author ">Alain Weill</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alexandre Y. Poppe&eventCode=SE-AU" class="more-by-this-author ">Alexandre Y. Poppe</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 49 / <a href="/core/product/BAA8043A0188B7311BEC14227EC02492" class="productParent" data-prod-id="BAA8043A0188B7311BEC14227EC02492">Issue 1</a> / 2022 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 March 2021</span><span class="pages">, pp. 49-54</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-21E1A21A4C1E603C7F6210551C58A028" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/21E1A21A4C1E603C7F6210551C58A028/S0317167121000378a.pdf/predictors_of_outcome_after_mechanical_thrombectomy_in_stroke_patients_aged_85_years.pdf" data-pdf-content-id="21E1A21A4C1E603C7F6210551C58A028" target="_blank" aria-label="Download PDF for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/21E1A21A4C1E603C7F6210551C58A028/core-reader" target="_blank" aria-label="View HTML full text for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"21E1A21A4C1E603C7F6210551C58A028","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="21E1A21A4C1E603C7F6210551C58A028" data-container="representation" aria-label="Export citation for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000378')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"21E1A21A4C1E603C7F6210551C58A028"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000378" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>The effectiveness of mechanical thrombectomy (MT) in elderly stroke patients remains debated. We aimed to describe outcomes and their predictors in a cohort of patients aged ≥ 85 years treated with MT.</p></div><div class='sec'><span class="bold">Methods:</span><p>Data from consecutive patients aged ≥ 85 years undergoing MT at two stroke centers between January 2016 and November 2019 were reviewed. Admission National Institutes of Health Stroke Scale (NIHSS), pre-stroke, and 3-month modified Rankin scale (mRS) were collected. Successful recanalization was defined as modified thrombolysis in cerebral ischemia score ≥ 2b. Good outcome was defined as mRS 0–3 or equal to pre-stroke mRS at 3 months.</p></div><div class='sec'><span class="bold">Results:</span><p>Of 151 included patients, successful recanalization was achieved in 74.2%. At 3 months, 44.7% of patients had a good outcome and 39% had died. Any intracranial hemorrhage (ICH) and symptomatic ICH occurred in 20.3% and 3.6%, respectively. Logistic regression analysis identiﬁed lower pre-stroke mRS score (adjusted odds ratio [aOR], 0.52; 95% CI, 0.36–0.76), lower admission NIHSS score (aOR, 0.90; 95% CI, 0.83–0.97), successful recanalization (aOR, 3.65; 95% CI, 1.32–10.09), and absence of ICH on follow-up imaging (aOR, 0.42; 95% CI, 0.08–0.75), to be independent predictors of good outcome. Patients with successful recanalization had a higher proportion of good outcome (45.3% vs 34.3%, p = 0.013) and lower mortality at 3 months (35.8% vs 48.6%, p = 0.006) compared to patients with unsuccessful recanalization.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Among patients aged ≥ 85 years, successful recanalization with MT is relatively common and associated with better 3-month outcome and lower mortality than failed recanalization. Attempting to achieve recanalization in elderly patients using MT appears reasonable.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.37" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.37" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="24FAF6FC573D0CCDB306177E03AC829E" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"24FAF6FC573D0CCDB306177E03AC829E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="24FAF6FC573D0CCDB306177E03AC829E" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="142004" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/autologous-hematopoietic-stem-cell-transplantation-for-chronic-inflammatory-demyelinating-polyradiculoneuropathy/24FAF6FC573D0CCDB306177E03AC829E"> Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Josée Masson-Roy&eventCode=SE-AU" class="more-by-this-author ">Josée Masson-Roy</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ari Breiner&eventCode=SE-AU" class="more-by-this-author ">Ari Breiner</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jodi Warman-Chardon&eventCode=SE-AU" class="more-by-this-author ">Jodi Warman-Chardon</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Catherine E. Pringle&eventCode=SE-AU" class="more-by-this-author ">Catherine E. Pringle</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=David Allan&eventCode=SE-AU" class="more-by-this-author ">David Allan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Christopher Bredeson&eventCode=SE-AU" class="more-by-this-author ">Christopher Bredeson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lothar Huebsch&eventCode=SE-AU" class="more-by-this-author ">Lothar Huebsch</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Natasha Kekre&eventCode=SE-AU" class="more-by-this-author ">Natasha Kekre</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael Lee Kennah&eventCode=SE-AU" class="more-by-this-author ">Michael Lee Kennah</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lisa Martin&eventCode=SE-AU" class="more-by-this-author ">Lisa Martin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sheryl McDiarmid&eventCode=SE-AU" class="more-by-this-author ">Sheryl McDiarmid</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sultan Altouri&eventCode=SE-AU" class="more-by-this-author ">Sultan Altouri</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Harold Atkins&eventCode=SE-AU" class="more-by-this-author ">Harold Atkins</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pierre R. Bourque&eventCode=SE-AU" class="more-by-this-author ">Pierre R. Bourque</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 48 / <a href="/core/product/87C162E6B0D2D716BF1DB5955A06A4F7" class="productParent" data-prod-id="87C162E6B0D2D716BF1DB5955A06A4F7">Issue 6</a> / 2021 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 February 2021</span><span class="pages">, pp. 760-766</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-24FAF6FC573D0CCDB306177E03AC829E" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/24FAF6FC573D0CCDB306177E03AC829E/S0317167121000305a.pdf/autologous_hematopoietic_stem_cell_transplantation_for_chronic_inflammatory_demyelinating_polyradiculoneuropathy.pdf" data-pdf-content-id="24FAF6FC573D0CCDB306177E03AC829E" target="_blank" aria-label="Download PDF for Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/24FAF6FC573D0CCDB306177E03AC829E/core-reader" target="_blank" aria-label="View HTML full text for Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"24FAF6FC573D0CCDB306177E03AC829E","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="24FAF6FC573D0CCDB306177E03AC829E" data-container="representation" aria-label="Export citation for Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000305')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Autologous Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"24FAF6FC573D0CCDB306177E03AC829E"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000305" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) refractory to conventional therapy can lead to marked disability and represents a therapeutic challenge.</p></div><div class='sec'><span class="bold">Objective:</span><p>To report five cases of treatment-refractory disabling CIDP treated with autologous hematopoietic stem cell transplantation (AHSCT).</p></div><div class='sec'><span class="bold">Methods:</span><p>This was a retrospective cohort study from a tertiary care referral center for both neuromuscular disease and AHSCT. Patients with CIDP treated with AHSCT between 2008 and 2020 were included. All patients had major persistent and disabling neuropathic deficits despite combinations of intensive immunosuppressive therapy. The primary outcome measures were: Medical Research Council sum score, Overall Neuropathy Limitations Scale and requirement for ongoing CIDP immunotherapy after transplantation. We also analyzed safety outcomes by documenting all severe AHSCT-related complications.</p></div><div class='sec'><span class="bold">Results:</span><p>Five patients with refractory CIDP underwent AHSCT. Three were classified as manifesting a typical syndrome, two were classified as the multifocal Lewis Sumner variant. The mean age at time of CIDP diagnosis was 33.4 years (range 24–46 years), with a median delay of 46 months (range 21–135 months) between diagnosis and AHSCT. The median follow-up period was 41 months. All five patients were able to wean off CIDP-related immunotherapy. Marked improvements in Medical Research Council scale and overall Neuropathy Limitations Scale were noted in 4/5 patients. One patient with longstanding neurogenic atrophy showed no improvement in disability scales. There were no treatment-related deaths or critical illnesses.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>AHSCT can achieve marked sustained clinical improvement of refractory CIDP and may allow for weaning off long-term complex immunotherapies.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.30" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.30" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="5F79F1468299FF3009C42F8FFD6B67D9" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"5F79F1468299FF3009C42F8FFD6B67D9","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="5F79F1468299FF3009C42F8FFD6B67D9" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="303267" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/utility-of-neuropathy-screening-for-wildtype-transthyretin-amyloidosis-patients/5F79F1468299FF3009C42F8FFD6B67D9"> Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Angela Russell&eventCode=SE-AU" class="more-by-this-author ">Angela Russell</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Christopher Hahn&eventCode=SE-AU" class="more-by-this-author ">Christopher Hahn</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sameer Chhibber&eventCode=SE-AU" class="more-by-this-author ">Sameer Chhibber</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lawrence Korngut&eventCode=SE-AU" class="more-by-this-author ">Lawrence Korngut</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Nowell M. Fine&eventCode=SE-AU" class="more-by-this-author ">Nowell M. Fine</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 48 / <a href="/core/product/B3FC9CE296A03E24C823578AF5FC9D31" class="productParent" data-prod-id="B3FC9CE296A03E24C823578AF5FC9D31">Issue 5</a> / September 2021 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 21 December 2020</span><span class="pages">, pp. 607-615</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-5F79F1468299FF3009C42F8FFD6B67D9" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/5F79F1468299FF3009C42F8FFD6B67D9/S0317167120002711a.pdf/utility_of_neuropathy_screening_for_wildtype_transthyretin_amyloidosis_patients.pdf" data-pdf-content-id="5F79F1468299FF3009C42F8FFD6B67D9" target="_blank" aria-label="Download PDF for Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/5F79F1468299FF3009C42F8FFD6B67D9/core-reader" target="_blank" aria-label="View HTML full text for Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"5F79F1468299FF3009C42F8FFD6B67D9","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="5F79F1468299FF3009C42F8FFD6B67D9" data-container="representation" aria-label="Export citation for Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120002711')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Utility of Neuropathy Screening for Wild-Type Transthyretin Amyloidosis Patients" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"5F79F1468299FF3009C42F8FFD6B67D9"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120002711" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Wild-type transthyretin amyloidosis (wtATTR) is an important cause of heart failure (HF); however, the prevalence and clinical significance of neurologic complications remains uncertain.</p></div><div class='sec'><span class="bold">Methods:</span><p>This analysis reports findings from a single-centre experience of routine neuropathy screening at the time of wtATTR diagnosis by nerve conduction studies and neurologist assessment, compared with age-matched controls.</p></div><div class='sec'><span class="bold">Results:</span><p>Forty-one wtATTR patients were included, 39 (95%) males, mean age 78.4 ± 7.7 years, 22 (54%) New York Heart Association (NYHA) class III–IV HF, along with 15 age-matched controls (mean age 77.1 ± 4.2 years, 80% male). Twenty-one (51%) wtATTR patients were diagnosed with polyneuropathy, 15 (37%) with spinal stenosis, 36 (88%) with carpal tunnel syndrome (CTS) and 14 (34%) with ulnar neuropathy. Comparison diagnoses among controls were 1 (7%), 0, 1 (7%) and 3 (20%), respectively. Among patients with NYHA class III–IV HF, 16 (73%) had polyneuropathy compared with 5 (26%) with class I–II (p < 0.01), odds ratio of 7.5 (95% confidence interval 1.9–29.9). After neuropathy screening, 19 (46%) patients were offered neurologic therapy and/or additional diagnostic evaluation. This included CTS release surgery (16, 39%), neuropathic pain medication (3, 7%), nerve block (1, 2%), wrist splinting (2, 5%) and foot care (1, 2%). Spine imaging was performed for 3 (7%) patients, and deltoid muscle and sural nerve biopsy for 1 (2%) patient.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Screening of wtATTR patients for neurologic complications resulted in a management change for nearly half. CTS, polyneuropathy and ulnar neuropathy were common. This approach warrants consideration as part of routine assessment for newly diagnosed wtATTR patients.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.271" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.271" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="05A568206C3F177EC282B6B91480D19C" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"05A568206C3F177EC282B6B91480D19C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="05A568206C3F177EC282B6B91480D19C" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="339862" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/stimulation-of-the-anterior-nucleus-of-the-thalamus-for-epilepsy-a-canadian-experience/05A568206C3F177EC282B6B91480D19C"> Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy: A Canadian Experience </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Manuel L. Herrera&eventCode=SE-AU" class="more-by-this-author ">Manuel L. Herrera</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ana Suller-Marti&eventCode=SE-AU" class="more-by-this-author ">Ana Suller-Marti</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Andrew Parrent&eventCode=SE-AU" class="more-by-this-author ">Andrew Parrent</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Keith MacDougall&eventCode=SE-AU" class="more-by-this-author ">Keith MacDougall</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jorge G. Burneo&eventCode=SE-AU" class="more-by-this-author ">Jorge G. Burneo</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 48 / <a href="/core/product/9519FD629DF81C0F3950D1C29120734B" class="productParent" data-prod-id="9519FD629DF81C0F3950D1C29120734B">Issue 4</a> / 2021 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 16 October 2020</span><span class="pages">, pp. 469-478</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-05A568206C3F177EC282B6B91480D19C" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/05A568206C3F177EC282B6B91480D19C/S0317167120002309a.pdf/stimulation_of_the_anterior_nucleus_of_the_thalamus_for_epilepsy_a_canadian_experience.pdf" data-pdf-content-id="05A568206C3F177EC282B6B91480D19C" target="_blank" aria-label="Download PDF for Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy: A Canadian Experience [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/05A568206C3F177EC282B6B91480D19C/core-reader" target="_blank" aria-label="View HTML full text for Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy: A Canadian Experience [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"05A568206C3F177EC282B6B91480D19C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="05A568206C3F177EC282B6B91480D19C" data-container="representation" aria-label="Export citation for Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy: A Canadian Experience">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120002309')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy: A Canadian Experience" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"05A568206C3F177EC282B6B91480D19C"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120002309" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objective:</span><p>To describe the experience with Anterior Nucleus of the Thalamus-Deep Brain Stimulation (ANT-DBS) for the treatment of epilepsy at a Canadian Center.</p></div><div class='sec'><span class="bold">Methods:</span><p>All patients who underwent ANT-DBS implantation between 2013 (first patient implanted at our center) and 2020 were included. These patients had therapy-resistant epilepsy (TRE), were not candidates for resective surgery, and failed vagus nerve stimulation (VNS) treatment. Baseline of monthly seizure frequency was calculated within 3 months prior to VNS placement. Monthly seizure frequency was assessed at different points along the timeline: 3 months before ANT-DBS implantation as well as 3, 6, 12, 24, 36, 48, 60, and 72 months after ANT-DBS device placement. At each time point, seizure frequency was compared to baseline.</p></div><div class='sec'><span class="bold">Results:</span><p>Six patients were implanted with ANT-DBS. Three (50%) patients had multifocal epilepsy, one (16.6%) had focal epilepsy, and two (33.4%) had combined generalized and focal epilepsy. Two patients with multifocal epilepsy experienced a seizure reduction >50% in the long-term follow-up. Three (50%) patients did not showed improvement: two with combined generalized and focal epilepsy and one with focal epilepsy. There were not surgical or device-related side effects. Two (33.3%) patients presented mild and transient headaches as a stimulation-related side effect.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>ANT-DBS is an effective and safe treatment for focal TRE. Our experience suggests that patients with multifocal epilepsy due to regional lesion may benefit from ANT-DBS the most. Further investigations are required to determine optimal parameters of stimulation.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.230" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.230" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="C3EA34405AC2C26BE6755FA75518A336" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"C3EA34405AC2C26BE6755FA75518A336","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="C3EA34405AC2C26BE6755FA75518A336" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="710173" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/choosing-wisely-neurology-recommendations-for-the-canadian-neurological-society/C3EA34405AC2C26BE6755FA75518A336"> Choosing Wisely Neurology: Recommendations for the Canadian Neurological Society </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Catherine Beyak&eventCode=SE-AU" class="more-by-this-author ">Catherine Beyak</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Fiona Costello&eventCode=SE-AU" class="more-by-this-author ">Fiona Costello</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jodie M. Burton&eventCode=SE-AU" class="more-by-this-author ">Jodie M. Burton</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Philippe Couillard&eventCode=SE-AU" class="more-by-this-author ">Philippe Couillard</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 48 / <a href="/core/product/7F105EC01A8720CD2D021ED56A6B8556" class="productParent" data-prod-id="7F105EC01A8720CD2D021ED56A6B8556">Issue 3</a> / 2021 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 22 September 2020</span><span class="pages">, pp. 308-311</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-C3EA34405AC2C26BE6755FA75518A336" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/C3EA34405AC2C26BE6755FA75518A336/S0317167120002103a.pdf/choosing_wisely_neurology_recommendations_for_the_canadian_neurological_society.pdf" data-pdf-content-id="C3EA34405AC2C26BE6755FA75518A336" target="_blank" aria-label="Download PDF for Choosing Wisely Neurology: Recommendations for the Canadian Neurological Society [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/C3EA34405AC2C26BE6755FA75518A336/core-reader" target="_blank" aria-label="View HTML full text for Choosing Wisely Neurology: Recommendations for the Canadian Neurological Society [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"C3EA34405AC2C26BE6755FA75518A336","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="C3EA34405AC2C26BE6755FA75518A336" data-container="representation" aria-label="Export citation for Choosing Wisely Neurology: Recommendations for the Canadian Neurological Society">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120002103')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Choosing Wisely Neurology: Recommendations for the Canadian Neurological Society" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"C3EA34405AC2C26BE6755FA75518A336"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120002103" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Choosing Wisely Canada (CWC) is a national branch of a global campaign advocating for fewer unnecessary tests and for optimizing patient care. Professional societies representing physicians, pharmacists, and nurses participate by generating lists of recommendations meant to reduce patient harm and resource mismanagement in healthcare. The Canadian Neurological Society (CNS) plays an important role in advocating for quality patient care demonstrated by deriving specific recommendations. This process is described.</p></div><div class='sec'><span class="bold">Method:</span><p>The CNS Choosing Wisely task force adapted 10 recommendations for Canadian neurology practice. These were approved by the CNS board, and subsequently ranked by CNS members.</p></div><div class='sec'><span class="bold">Results:</span><p>Ten recommendations were brought forward and ranked in a survey completed by CNS members. Survey ranking is presented. The top five recommendations were selected and optimized, resulting in seven key recommendations.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>The recommendations set forth by the CNS will help with resource stewardship and patient safety in the delivery of neurological care by healthcare providers in Canada.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.210" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.210" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Review Article</h4> <div class="representation overview search" data-prod-id="75F0AF329F7B28F83F8BF743CB1CBAF4" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"75F0AF329F7B28F83F8BF743CB1CBAF4","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="75F0AF329F7B28F83F8BF743CB1CBAF4" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="1958143" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/imaging-developmental-and-interventional-plasticity-following-perinatal-stroke/75F0AF329F7B28F83F8BF743CB1CBAF4"> Imaging Developmental and Interventional Plasticity Following Perinatal Stroke </a></h3></li> <li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Brandon T. Craig&eventCode=SE-AU" class="more-by-this-author ">Brandon T. Craig</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alicia Hilderley&eventCode=SE-AU" class="more-by-this-author ">Alicia Hilderley</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Adam Kirton&eventCode=SE-AU" class="more-by-this-author ">Adam Kirton</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Helen L. Carlson&eventCode=SE-AU" class="more-by-this-author ">Helen L. Carlson</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> / Volume 48 / <a href="/core/product/CF2640EA4250619229DC685589BF5474" class="productParent" data-prod-id="CF2640EA4250619229DC685589BF5474">Issue 2</a> / 2021 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 30 July 2020</span><span class="pages">, pp. 157-171</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-75F0AF329F7B28F83F8BF743CB1CBAF4" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/75F0AF329F7B28F83F8BF743CB1CBAF4/S0317167120001663a.pdf/imaging_developmental_and_interventional_plasticity_following_perinatal_stroke.pdf" data-pdf-content-id="75F0AF329F7B28F83F8BF743CB1CBAF4" target="_blank" aria-label="Download PDF for Imaging Developmental and Interventional Plasticity Following Perinatal Stroke [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/75F0AF329F7B28F83F8BF743CB1CBAF4/core-reader" target="_blank" aria-label="View HTML full text for Imaging Developmental and Interventional Plasticity Following Perinatal Stroke [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","productId":"75F0AF329F7B28F83F8BF743CB1CBAF4","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="75F0AF329F7B28F83F8BF743CB1CBAF4" data-container="representation" aria-label="Export citation for Imaging Developmental and Interventional Plasticity Following Perinatal Stroke">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167120001663')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Imaging Developmental and Interventional Plasticity Following Perinatal Stroke" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/editor-s-choice","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"75F0AF329F7B28F83F8BF743CB1CBAF4"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167120001663" class="content"> <div class="abstract" data-abstract-type="normal"><p>Perinatal stroke occurs around the time of birth and leads to lifelong neurological disabilities including hemiparetic cerebral palsy. Magnetic resonance imaging (MRI) has revolutionized our understanding of developmental neuroplasticity following early injury, quantifying volumetric, structural, functional, and metabolic compensatory changes after perinatal stroke. Such techniques can also be used to investigate how the brain responds to treatment (interventional neuroplasticity). Here, we review the current state of knowledge of how established and emerging neuroimaging modalities are informing neuroplasticity models in children with perinatal stroke. Specifically, we review structural imaging characterizing lesion characteristics and volumetrics, diffusion tensor imaging investigating white matter tracts and networks, task-based functional MRI for localizing function, resting state functional imaging for characterizing functional connectomes, and spectroscopy examining neurometabolic changes. Key challenges and exciting avenues for future investigations are also considered.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.166" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2020.166" data-link-target="_blank"></div> </div> </div> </div> </div> </div> <hr/> <div class="pagination-centered" data-test-id="paginationSearchResult"> <p class="paragraph_05 margin-bottom-small">Page 1 of 3</p> <ul class="pagination"> <li class="unavailable"><span class="in-active-item">First</span></li> <li class="unavailable"><span class="in-active-item">« Prev</span></li> <li class="current"><a href="?pageNum=1" data-page-number="1" aria-label="Page 1">1</a></li> <li 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