Canadian Journal of Neurological Sciences: Volume 49 - Issue 1

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if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="30F749A81026FF17F23A57D82003C3EC" data-container="representation" aria-label="Export citation for Canadian Guidelines for Hereditary Transthyretin Amyloidosis Polyneuropathy Management">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000342')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Canadian Guidelines for Hereditary Transthyretin Amyloidosis Polyneuropathy Management" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"30F749A81026FF17F23A57D82003C3EC"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000342" class="content"> <div class="abstract" data-abstract-type="normal"><p>Hereditary transthyretin-mediated (hATTR) amyloidosis is a progressive disease caused by mutations in the TTR gene leading to multisystem organ dysfunction. Pathogenic TTR aggregation, misfolding, and fibrillization lead to deposition of amyloid in multiple body organs and frequently involve the peripheral nerve system and the heart. Common neurologic manifestations include: sensorimotor polyneuropathy (PN), autonomic neuropathy, small-fiber PN, and carpal tunnel syndrome. Many patients have significant progression due to diagnostic delays as hATTR PN is not considered within the differential diagnosis. Recently, two effective novel disease-modifying therapies, inotersen and patisiran, were approved by Health Canada for the treatment of hATTR PN. Early diagnosis is crucial for the timely introduction of these disease-modifying treatments that reduce impairments, improve quality of life, and extend survival. In this guideline, we aim to improve awareness and outcomes of hATTR PN by making recommendations directed to the diagnosis, monitoring, and treatment in Canada.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.34" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.34" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="258C79CB9612091A3A13A14909FEABE6" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" 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href="/core/search?filters%5BauthorTerms%5D=Jennifer Taher&eventCode=SE-AU" class="more-by-this-author ">Jennifer Taher</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Taline Naranian&eventCode=SE-AU" class="more-by-this-author ">Taline Naranian</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yu-Yan Poon&eventCode=SE-AU" class="more-by-this-author ">Yu-Yan Poon</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Aristide Merola&eventCode=SE-AU" class="more-by-this-author ">Aristide Merola</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Tiago Mestre&eventCode=SE-AU" class="more-by-this-author ">Tiago Mestre</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Oksana Suchowersky&eventCode=SE-AU" class="more-by-this-author ">Oksana Suchowersky</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vathany Kulasingam&eventCode=SE-AU" class="more-by-this-author ">Vathany Kulasingam</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alfonso Fasano&eventCode=SE-AU" class="more-by-this-author ">Alfonso Fasano</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 20 April 2021</span><span class="pages">, pp. 19-28</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-258C79CB9612091A3A13A14909FEABE6" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/258C79CB9612091A3A13A14909FEABE6/S0317167121000780a.pdf/vitamins_and_infusion_of_levodopacarbidopa_intestinal_gel.pdf" data-pdf-content-id="258C79CB9612091A3A13A14909FEABE6" target="_blank" aria-label="Download PDF for Vitamins and Infusion of Levodopa-Carbidopa Intestinal Gel [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/258C79CB9612091A3A13A14909FEABE6/core-reader" target="_blank" aria-label="View HTML full text for Vitamins and Infusion of Levodopa-Carbidopa Intestinal Gel [Opens in a new window]" 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data-prod-id="258C79CB9612091A3A13A14909FEABE6" data-container="representation" aria-label="Export citation for Vitamins and Infusion of Levodopa-Carbidopa Intestinal Gel">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000780')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Vitamins and Infusion of Levodopa-Carbidopa Intestinal Gel" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"258C79CB9612091A3A13A14909FEABE6"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000780" class="content"> <div class="abstract" data-abstract-type="normal"><p>Levodopa-carbidopa intestinal gel infusion (LCIG) is an established therapy for advanced Parkinson disease (PD), resulting in a significant improvement of quality of life. With increased LCIG adoption worldwide, potential complications due to abnormal vitamin absorption or metabolism have been reported in these patients. Neurologists are unfamiliar with vitamins physiology and pathophysiological mechanisms in case of their deficiency. Unfortunately, clinical and laboratory guidelines related to vitamin monitoring and supplementation in the context of treatment with LCIG are not available. We herein summarize the current knowledge on three vitamins that are reduced with LCIG therapy reporting on their physiology, laboratory testing, and clinical impact of their deficiency/excess. In addition, we proposed an opinion-based recommendation for clinicians treating LCIG patients. Patients and caregivers should be informed about the risk of vitamin deficiency. Vitamin B12, homocysteine, and methylmalonic acid (MMA) should be tested before starting LCIG, six months after and once/year thereafter. Vitamin B6 and folate testing is not universally available but it should be considered if homocysteine is elevated but MMA and/or total vitamin B12 are normal. Prophylaxis of vitamin deficiency should be started as soon as LCIG is implemented, possibly even before. Dietary recommendations are enough in most patients although a subgroup of patients is at higher risk and should receive Vitamin B12 regularly and cycles of B6. Finally, once diagnosed a vitamin deficiency should be readily treated and accompanied by clinical and laboratory monitoring. Resistant cases should receive non-oral routes of administration and possibly discontinue LCIG, even temporarily.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.78" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.78" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="1AB6C88C39FF1292642C3FBC8FC81C56" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"1AB6C88C39FF1292642C3FBC8FC81C56","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="1AB6C88C39FF1292642C3FBC8FC81C56" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="171606" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/dystonia-in-performing-artists-beyond-focal-hand-dystonia/1AB6C88C39FF1292642C3FBC8FC81C56"> Dystonia in Performing Artists: Beyond Focal Hand Dystonia </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Somdattaa Ray&eventCode=SE-AU" class="more-by-this-author ">Somdattaa Ray</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pramod K. Pal&eventCode=SE-AU" class="more-by-this-author ">Pramod K. Pal</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 March 2021</span><span class="pages">, pp. 29-37</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-1AB6C88C39FF1292642C3FBC8FC81C56" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/1AB6C88C39FF1292642C3FBC8FC81C56/S031716712100041Xa.pdf/dystonia_in_performing_artists_beyond_focal_hand_dystonia.pdf" data-pdf-content-id="1AB6C88C39FF1292642C3FBC8FC81C56" target="_blank" aria-label="Download PDF for Dystonia in Performing Artists: Beyond Focal Hand Dystonia [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/1AB6C88C39FF1292642C3FBC8FC81C56/core-reader" target="_blank" aria-label="View HTML full text for Dystonia in Performing Artists: Beyond Focal Hand Dystonia [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"1AB6C88C39FF1292642C3FBC8FC81C56","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="1AB6C88C39FF1292642C3FBC8FC81C56" data-container="representation" aria-label="Export citation for Dystonia in Performing Artists: Beyond Focal Hand Dystonia">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS031716712100041X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Dystonia in Performing Artists: Beyond Focal Hand Dystonia" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"1AB6C88C39FF1292642C3FBC8FC81C56"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS031716712100041X" class="content"> <div class="abstract" data-abstract-type="normal"><p>Overuse of specific muscles in perfecting movements in performing arts makes an artist prone to many medical conditions. Musicians’ hand dystonia is focal task-specific dystonia (FTSD) of hand among musicians that has been extensively studied. However, embouchure, lower limbs, and laryngeal muscles can also be affected among musicians. Embouchure dystonia (ED) refers to dystonia of the perioral and facial muscles that occurs in musicians while playing embouchure instruments. It is essential to identify ED since the dystonia might become persistent and non-task-specific if the musician continues to play the instrument. Task-specific dystonia of lower limbs among musicians has been exclusively reported among drummers. The diagnosis rests on electromyogram (EMG) of the involved muscles during the task. Singer’s dystonia (SD) refers to task-specific laryngeal dystonia that occurs only while singing. The diagnosis of SD is based on laryngeal EMG and spectrographic analysis. Cortical hyperexcitability, loss of inhibition, and aberrant plasticity are central to the pathogenesis in both ED and musicians’ hand dystonia. The pathophysiological studies in SD are limited. This review aims to discuss the lesser known dystonias among performing artists – ED, FTSD of lower limb, and SD.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.41" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.41" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Original Article</h4> <div class="representation overview search" data-prod-id="CCF9C2FBD393E8C1BD7510A3663D80E7" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" 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class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Mohammad Aladawi&eventCode=SE-AU" class="more-by-this-author ">Mohammad Aladawi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Mohamed Elfil&eventCode=SE-AU" class="more-by-this-author ">Mohamed Elfil</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Baha Abu-Esheh&eventCode=SE-AU" class="more-by-this-author ">Baha Abu-Esheh</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Deaa Abu Jazar&eventCode=SE-AU" class="more-by-this-author ">Deaa Abu Jazar</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ahmad Armouti&eventCode=SE-AU" class="more-by-this-author ">Ahmad Armouti</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ahmed Bayoumi&eventCode=SE-AU" class="more-by-this-author ">Ahmed Bayoumi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ezequiel Piccione&eventCode=SE-AU" class="more-by-this-author ">Ezequiel Piccione</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 05 May 2021</span><span class="pages">, pp. 38-48</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-CCF9C2FBD393E8C1BD7510A3663D80E7" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/CCF9C2FBD393E8C1BD7510A3663D80E7/S0317167121001025a.pdf/guillain_barre_syndrome_as_a_complication_of_covid19_a_systematic_review.pdf" data-pdf-content-id="CCF9C2FBD393E8C1BD7510A3663D80E7" target="_blank" aria-label="Download PDF for Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/CCF9C2FBD393E8C1BD7510A3663D80E7/core-reader" target="_blank" aria-label="View HTML full text for Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review [Opens in a new window]" 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class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>In January 2020, the first case of Guillain Barre syndrome (GBS) due to COVID-19 was documented in China. GBS is known to be postinfectious following several types of infections. Although causality can only be proven through large epidemiological studies, we intended to study this association by a thorough review of the literature.</p></div><div class='sec'><span class="bold">Methods:</span><p>We searched PubMed, EMBASE, and Google scholar and included all papers with English or Spanish full text and original data of patients with GBS and recent COVID infection. Variables of interest were demographics, diagnostic investigations, and the latency between arboviral and neurological symptoms. Further variables were pooled to identify GBS clinical and electrophysiological variants, used treatments, and outcomes. The certainty of GBS diagnosis was verified using Brighton criteria.</p></div><div class='sec'><span class="bold">Results:</span><p>We identified a total of 109 GBS cases. Ninety-nine cases had confirmed COVID-19 infection with an average age of 56.07 years. The average latency period between the arboviral symptoms and neurologic manifestations for confirmed COVID-19 cases was 12.2 d. The predominant GBS clinical and electromyography variants were the classical sensorimotor GBS and acute demyelinating polyneuropathy respectively. Forty cases required intensive care, 33 cases required mechanical ventilation, and 6 cases were complicated by death.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Studies on COVID-19-related GBS commonly reported sensorimotor demyelinating GBS with frequent facial palsy. The time between the onset of infectious and neurological symptoms suggests a postinfectious mechanism. Early diagnosis of GBS in COVID-19 patients is important as it might be associated with a severe disease course requiring intensive care and mechanical ventilation.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.102" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.102" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="21E1A21A4C1E603C7F6210551C58A028" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" 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<li> Part of: <ul class="partOfCollection"> <li><a href="/core/product/identifier/DFF7E9D6-32B8-43DD-A093-075255FB2ABF/type/BESPOKE_COLLECTION" class="">CJNS Editor’s Choice Articles</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Laurent Derex&eventCode=SE-AU" class="more-by-this-author ">Laurent Derex</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Julie Haesebaert&eventCode=SE-AU" class="more-by-this-author ">Julie Haesebaert</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Céline Odier&eventCode=SE-AU" class="more-by-this-author ">Céline Odier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Walid Alesefir&eventCode=SE-AU" class="more-by-this-author ">Walid Alesefir</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yves Berthezène&eventCode=SE-AU" class="more-by-this-author ">Yves Berthezène</a><span 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href="/core/search?filters%5BauthorTerms%5D=Christian Stapf&eventCode=SE-AU" class="more-by-this-author ">Christian Stapf</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alain Weill&eventCode=SE-AU" class="more-by-this-author ">Alain Weill</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alexandre Y. Poppe&eventCode=SE-AU" class="more-by-this-author ">Alexandre Y. Poppe</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 March 2021</span><span class="pages">, pp. 49-54</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-21E1A21A4C1E603C7F6210551C58A028" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/21E1A21A4C1E603C7F6210551C58A028/S0317167121000378a.pdf/predictors_of_outcome_after_mechanical_thrombectomy_in_stroke_patients_aged_85_years.pdf" data-pdf-content-id="21E1A21A4C1E603C7F6210551C58A028" target="_blank" aria-label="Download PDF for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/21E1A21A4C1E603C7F6210551C58A028/core-reader" target="_blank" aria-label="View HTML full text for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"21E1A21A4C1E603C7F6210551C58A028","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="21E1A21A4C1E603C7F6210551C58A028" data-container="representation" aria-label="Export citation for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000378')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Predictors of Outcome After Mechanical Thrombectomy in Stroke Patients Aged ≥85 Years" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"21E1A21A4C1E603C7F6210551C58A028"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000378" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>The effectiveness of mechanical thrombectomy (MT) in elderly stroke patients remains debated. We aimed to describe outcomes and their predictors in a cohort of patients aged ≥ 85 years treated with MT.</p></div><div class='sec'><span class="bold">Methods:</span><p>Data from consecutive patients aged ≥ 85 years undergoing MT at two stroke centers between January 2016 and November 2019 were reviewed. Admission National Institutes of Health Stroke Scale (NIHSS), pre-stroke, and 3-month modified Rankin scale (mRS) were collected. Successful recanalization was defined as modified thrombolysis in cerebral ischemia score ≥ 2b. Good outcome was defined as mRS 0–3 or equal to pre-stroke mRS at 3 months.</p></div><div class='sec'><span class="bold">Results:</span><p>Of 151 included patients, successful recanalization was achieved in 74.2%. At 3 months, 44.7% of patients had a good outcome and 39% had died. Any intracranial hemorrhage (ICH) and symptomatic ICH occurred in 20.3% and 3.6%, respectively. Logistic regression analysis identiﬁed lower pre-stroke mRS score (adjusted odds ratio [aOR], 0.52; 95% CI, 0.36–0.76), lower admission NIHSS score (aOR, 0.90; 95% CI, 0.83–0.97), successful recanalization (aOR, 3.65; 95% CI, 1.32–10.09), and absence of ICH on follow-up imaging (aOR, 0.42; 95% CI, 0.08–0.75), to be independent predictors of good outcome. Patients with successful recanalization had a higher proportion of good outcome (45.3% vs 34.3%, p = 0.013) and lower mortality at 3 months (35.8% vs 48.6%, p = 0.006) compared to patients with unsuccessful recanalization.</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Among patients aged ≥ 85 years, successful recanalization with MT is relatively common and associated with better 3-month outcome and lower mortality than failed recanalization. Attempting to achieve recanalization in elderly patients using MT appears reasonable.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.37" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.37" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="1DC6D829E1FF3C6BD2ACAD11FF27993C" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"1DC6D829E1FF3C6BD2ACAD11FF27993C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="1DC6D829E1FF3C6BD2ACAD11FF27993C" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="283388" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/nearocclusion-is-a-common-variant-of-carotid-stenosis-study-and-systematic-review/1DC6D829E1FF3C6BD2ACAD11FF27993C"> Near-Occlusion is a Common Variant of Carotid Stenosis: Study and Systematic Review </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Elias Johansson&eventCode=SE-AU" class="more-by-this-author ">Elias Johansson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Allan J. Fox&eventCode=SE-AU" class="more-by-this-author ">Allan J. Fox</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 14 May 2021</span><span class="pages">, pp. 55-61</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-1DC6D829E1FF3C6BD2ACAD11FF27993C" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/1DC6D829E1FF3C6BD2ACAD11FF27993C/S0317167121000500a.pdf/nearocclusion_is_a_common_variant_of_carotid_stenosis_study_and_systematic_review.pdf" data-pdf-content-id="1DC6D829E1FF3C6BD2ACAD11FF27993C" target="_blank" aria-label="Download PDF for Near-Occlusion is a Common Variant of Carotid Stenosis: Study and Systematic Review [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/1DC6D829E1FF3C6BD2ACAD11FF27993C/core-reader" target="_blank" aria-label="View HTML full text for Near-Occlusion is a Common Variant of Carotid Stenosis: Study and Systematic Review [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"1DC6D829E1FF3C6BD2ACAD11FF27993C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="1DC6D829E1FF3C6BD2ACAD11FF27993C" data-container="representation" aria-label="Export citation for Near-Occlusion is a Common Variant of Carotid Stenosis: Study and Systematic Review">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000500')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Near-Occlusion is a Common Variant of Carotid Stenosis: Study and Systematic Review" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"1DC6D829E1FF3C6BD2ACAD11FF27993C"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000500" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Symptomatic carotid near-occlusion is often described as rare. Recent studies have shown that near-occlusions are overlooked, especially near-occlusion without full collapse (with a small but normal-appearing distal internal carotid artery).</p></div><div class='sec'><span class="bold">Objective:</span><p>To assess the prevalence of near-occlusion among symptomatic ≥50% carotid stenosis, incidence of symptomatic near-occlusion, and review the literature.</p></div><div class='sec'><span class="bold">Methods:</span><p>Prospective controlled single-center cross-sectional study. Consecutive cases with symptomatic ≥50% carotid stenosis were examined with computed tomography angiography (CTA). The CTAs were assessed for near-occlusion by two observers. A systematic literature review was performed with emphasis on how study design affects prevalence estimate.</p></div><div class='sec'><span class="bold">Results:</span><p>Totally, 186 patients with symptomatic ≥50% carotid stenosis were included, 34% (<span class='italic'>n</span> = 63, 95% CI 27, 41) had near-occlusion. The incidence of symptomatic near-occlusion was 3.4 (95% CI 2.5, 4.2) per 100,000 person-years. Inter-rater κ was 0.71. The average prevalence of near-occlusion among symptomatic ≥50% carotid stenosis was higher in studies with good design (30%, range 27%–34%) than studies without good design (9%, range 2%–10%).</p></div><div class='sec'><span class="bold">Conclusions:</span><p>Near-occlusion is common variant of symptomatic ≥50% carotid stenosis, both in the current study and in all previous studies of good design. Studies that suggest that near-occlusion is rare have had methodological issues.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.50" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.50" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="BC4FFEFE87A0A880D1F0F435E3D336CF" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"BC4FFEFE87A0A880D1F0F435E3D336CF","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="BC4FFEFE87A0A880D1F0F435E3D336CF" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="236258" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/management-of-ruptured-intracranial-aneurysms-in-the-postinternational-subarachnoid-aneurysm-trial-era-a-singlecentre-prospective-series/BC4FFEFE87A0A880D1F0F435E3D336CF"> Management of Ruptured Intracranial Aneurysms in the Post-International Subarachnoid Aneurysm Trial Era: A Single-Centre Prospective Series </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Alexander D. Wong&eventCode=SE-AU" class="more-by-this-author ">Alexander D. Wong</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rufus Alubankudi&eventCode=SE-AU" class="more-by-this-author ">Rufus Alubankudi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Judith Jarrett&eventCode=SE-AU" class="more-by-this-author ">Judith Jarrett</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Thien J. Huynh&eventCode=SE-AU" class="more-by-this-author ">Thien J. Huynh</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Adam A. Dmytriw&eventCode=SE-AU" class="more-by-this-author ">Adam A. Dmytriw</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Gwynedd E. Pickett&eventCode=SE-AU" class="more-by-this-author ">Gwynedd E. Pickett</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 17 March 2021</span><span class="pages">, pp. 62-69</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-BC4FFEFE87A0A880D1F0F435E3D336CF" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/BC4FFEFE87A0A880D1F0F435E3D336CF/S0317167121000457a.pdf/management_of_ruptured_intracranial_aneurysms_in_the_postinternational_subarachnoid_aneurysm_trial_era_a_singlecentre_prospective_series.pdf" data-pdf-content-id="BC4FFEFE87A0A880D1F0F435E3D336CF" target="_blank" aria-label="Download PDF for Management of Ruptured Intracranial Aneurysms in the Post-International Subarachnoid Aneurysm Trial Era: A Single-Centre Prospective Series [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/BC4FFEFE87A0A880D1F0F435E3D336CF/core-reader" target="_blank" aria-label="View HTML full text for Management of Ruptured Intracranial Aneurysms in the Post-International Subarachnoid Aneurysm Trial Era: A Single-Centre Prospective Series [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"BC4FFEFE87A0A880D1F0F435E3D336CF","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="BC4FFEFE87A0A880D1F0F435E3D336CF" data-container="representation" aria-label="Export citation for Management of Ruptured Intracranial Aneurysms in the Post-International Subarachnoid Aneurysm Trial Era: A Single-Centre Prospective Series">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000457')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Management of Ruptured Intracranial Aneurysms in the Post-International Subarachnoid Aneurysm Trial Era: A Single-Centre Prospective Series" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"BC4FFEFE87A0A880D1F0F435E3D336CF"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000457" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Aneurysmal subarachnoid haemorrhage (aSAH) is associated with significant morbidity and mortality. The International Subarachnoid Aneurysm Trial (ISAT) reported reduced morbidity in patients treated with endovascular coiling versus surgical clipping. However, recent studies suggest that there is no significant difference in clinical outcomes. This study examines the outcomes of either technique for treating aSAH during the 15 years post-ISAT at a Canadian quaternary centre.</p></div><div class='sec'><span class="bold">Methods:</span><p>We reviewed prospectively collected data of patients admitted with aSAH from January 2002 to December 2017. Glasgow Outcome Scale (GOS) was compared at discharge, 6 months and 12 months’ follow-up using univariate and multivariable ordinal logistic regression. Post-operative complications were assessed using binary logistic regression.</p></div><div class='sec'><span class="bold">Results:</span><p>Two-hundred and eighty-seven patients were treated with coiling and 95 patients with clipping. The mean age of clipped patients was significantly younger, and hypertension was significantly commoner in coiled patients. A greater proportion of coiled aneurysms were located in the posterior circulation. No difference in the odds of having a favourable GOS was seen between patients who were clipped versus coiled at any of follow-up time points on univariate or multivariable analysis. In both treatment groups, patient recovery to independence (GOS 4–5) was seen from discharge to 6 months, but not from 6 to 12 months’ follow-up, without difference between clipping and coiling.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>These real-world findings suggest clipping remains an effective and important treatment option for patients with aSAH who do not meet ISAT inclusion criteria. The results can assist in clinical decision-making processes and understanding of the natural recovery progression of aSAH.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.45" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.45" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="EA7614EC76816B30FA4B5B6D9FFB90D5" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" 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class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Yi Yan&eventCode=SE-AU" class="more-by-this-author ">Yi Yan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kai Hu&eventCode=SE-AU" class="more-by-this-author ">Kai Hu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Susan Alcock&eventCode=SE-AU" class="more-by-this-author ">Susan Alcock</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Esseddeeg Ghrooda&eventCode=SE-AU" class="more-by-this-author ">Esseddeeg Ghrooda</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Anurag Trivedi&eventCode=SE-AU" class="more-by-this-author ">Anurag Trivedi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=James McEachern&eventCode=SE-AU" class="more-by-this-author ">James McEachern</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Zul Kaderali&eventCode=SE-AU" class="more-by-this-author ">Zul Kaderali</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jai Shankar&eventCode=SE-AU" class="more-by-this-author ">Jai Shankar</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 February 2021</span><span class="pages">, pp. 70-75</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-EA7614EC76816B30FA4B5B6D9FFB90D5" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" 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class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Purpose:</span><p>Endovascular thrombectomy (EVT) significantly improves outcomes for acute ischemic stroke patients with large vessel occlusion (LVO) who present in a time sensitive manner. Prolonged EVT access times may reduce benefits for eligible patients. We evaluated the efficiency of EVT services including EVT rates, onset-to-CTA time and onset-to-groin puncture time in our province.</p></div><div class='sec'><span class="bold">Materials and methods:</span><p>Three areas were defined: zone I- urban region, zone II-areas within 1 h drive distance from the Comprehensive Stroke Center (CSC); and zone III-areas more than 1hr drive distance from the CSC. In this retrospective cohort study, EVT rate, onset-to-groin puncture time and onset-to-CTA time were compared among the three groups using <span class='italic'>Krustal–Wallis</span> and <span class='italic'>Wilcoxon</span> tests.</p></div><div class='sec'><span class="bold">Results:</span><p>The EVT rate per 100,000 inhabitants for urban zone I was 8.6 as compared to 5.1 in zone II, and 7.5 in zone III. Compared to zone I (114 min; 95% CI (96, 132); n = 128), mean onset-to-CTA time was 19 min longer in zone II (133 min; 95% CI (77, 189); n = 23; p = 0.0459) and 103 min longer in zone III (217 min, 95% CI (162, 272); n = 44; p < 0.0001). Compared to zone I (209 min, 95% CI (181, 238)), mean onset-to-groin puncture time was 22 min longer in zone II (231 min, 95% CI (174, 288); p = 0.046) but 163 min longer in zone III (372 min, 95% CI (312, 432); p < 0.0001).</p></div><div class='sec'><span class="bold">Conclusion:</span><p>EVT access in rural areas is considerably reduced with significantly longer onset-to-groin puncture times and onset-to-CTA times when compared to our urban area. This may help in modifying the patient transfer policy for EVT referral.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.35" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.35" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="3A4484323E024DBDE22FDADCBA10B122" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"3A4484323E024DBDE22FDADCBA10B122","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="3A4484323E024DBDE22FDADCBA10B122" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="316615" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/stroke-in-maletofemale-transgenders-a-systematic-review-and-metaanalysis/3A4484323E024DBDE22FDADCBA10B122"> Stroke in Male-to-Female Transgenders: A Systematic Review and Meta-Analysis </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Katrina Hannah D. Ignacio&eventCode=SE-AU" class="more-by-this-author ">Katrina Hannah D. Ignacio</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jose Danilo B. Diestro&eventCode=SE-AU" class="more-by-this-author ">Jose Danilo B. Diestro</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Adrian I. Espiritu&eventCode=SE-AU" class="more-by-this-author ">Adrian I. Espiritu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Maria Carissa Pineda-Franks&eventCode=SE-AU" class="more-by-this-author ">Maria Carissa Pineda-Franks</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 March 2021</span><span class="pages">, pp. 76-83</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-3A4484323E024DBDE22FDADCBA10B122" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/3A4484323E024DBDE22FDADCBA10B122/S0317167121000548a.pdf/stroke_in_maletofemale_transgenders_a_systematic_review_and_metaanalysis.pdf" data-pdf-content-id="3A4484323E024DBDE22FDADCBA10B122" target="_blank" aria-label="Download PDF for Stroke in Male-to-Female Transgenders: A Systematic Review and Meta-Analysis [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/3A4484323E024DBDE22FDADCBA10B122/core-reader" target="_blank" aria-label="View HTML full text for Stroke in Male-to-Female Transgenders: A Systematic Review and Meta-Analysis [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"3A4484323E024DBDE22FDADCBA10B122","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); 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However, similar data on male-to-female (MTF) transgenders, another important population that receives hormonal therapy is lacking. Existing studies in MTF transgenders are skewed toward mental health and health-harming behaviors while few have focused on chronic health conditions. Our study aims to review the existing data on stroke in MTF transgenders and perform a quantitative analysis on the frequency of this condition in this special population.</p></div><div class='sec'><span class="bold">Methods:</span><p>PubMed, Cochrane, Scopus, Embase, ClinicalTrials.gov, and Web of Science were systematically searched for studies that reported data on the occurrence of cerebrovascular diseases in MTF transgenders. We reported the hormonal regimens, clinical characteristics, and outcomes of stroke in MTF transgenders. A meta-analysis of proportions was performed by the random-effects model to compute for the frequency of cerebrovascular events in MTF transgenders.</p></div><div class='sec'><span class="bold">Results:</span><p>Fourteen studies were included in the qualitative analysis while five studies were included in the quantitative analysis. A total of 109 MTF transgenders (Mean 14; range 1–53) suffered a cerebrovascular event. Random-effect modeling analysis showed an overall estimated frequency of 2% for cerebrovascular events in transgenders with a moderate degree of heterogeneity (I<span class='sup'>2</span> = 62%).</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Hormonal therapy in MTF transgenders may confer cardiovascular risks in this population. However, more population-based studies that include clinical characteristics and outcomes of chronic health diseases in MTF transgenders are warranted. Such studies may be crucial in directing future guidelines on the health care and management of MTF transgenders.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.54" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.54" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="133A74C9D8918013BBA7AE6DE800DCBC" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"133A74C9D8918013BBA7AE6DE800DCBC","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="133A74C9D8918013BBA7AE6DE800DCBC" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="206848" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/what-happens-to-the-worried-well-followup-of-subjective-cognitive-impairment/133A74C9D8918013BBA7AE6DE800DCBC"> What Happens to the Worried Well? Follow-Up of Subjective Cognitive Impairment </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Margaret Sutherland&eventCode=SE-AU" class="more-by-this-author ">Margaret Sutherland</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Andrew Kirk&eventCode=SE-AU" class="more-by-this-author ">Andrew Kirk</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Chandima P. Karunanayake&eventCode=SE-AU" class="more-by-this-author ">Chandima P. Karunanayake</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Megan E. O’Connell&eventCode=SE-AU" class="more-by-this-author ">Megan E. O’Connell</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Debra G. Morgan&eventCode=SE-AU" class="more-by-this-author ">Debra G. Morgan</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 March 2021</span><span class="pages">, pp. 84-92</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-133A74C9D8918013BBA7AE6DE800DCBC" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/133A74C9D8918013BBA7AE6DE800DCBC/S0317167121000391a.pdf/what_happens_to_the_worried_well_followup_of_subjective_cognitive_impairment.pdf" data-pdf-content-id="133A74C9D8918013BBA7AE6DE800DCBC" target="_blank" aria-label="Download PDF for What Happens to the Worried Well? 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Follow-Up of Subjective Cognitive Impairment">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000391')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for What Happens to the Worried Well? Follow-Up of Subjective Cognitive Impairment" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"133A74C9D8918013BBA7AE6DE800DCBC"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000391" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Increasing concern around perceived neurocognitive decline is increasing the number of referrals to specialists and anxiety for patients. We aimed to explore the likelihood of the “worried well” experiencing neurocognitive decline and developing a neurological diagnosis.</p></div><div class='sec'><span class="bold">Methods:</span><p>A total of 166 “worried well” patients who attended the Rural and Remote Memory Clinic (RRMC) between 2004 and 2019 were included in this study. Demographic, health, social, and behavioral factors were measured at the initial visit. Mini-Mental State Examination (MMSE), Center for Epidemiologic Studies Depression Scale (CESD), and Functional Activities Questionnaire (FAQ) scores were measured and compared at initial assessment and at 1-year follow-up. MMSE scores over time were assessed with a mean follow-up of 2.95 years (SD 2.87).</p></div><div class='sec'><span class="bold">Results:</span><p>No statistically significant difference was seen in MMSE, CESD, or FAQ scores when comparing clinic day to 1-year follow-up, and no consistent pattern of MMSE score over time was seen. Of the 166 patients with subjective cognitive impairment (SCI) on initial assessment, 5 were diagnosed with Alzheimer’s disease (AD) at 8.5, 3.5, 5, 3, and 1.75 years; 2 were diagnosed with MCI at 1 and 2 years; 1 was diagnosed with vascular cognitive impairment at 5 years; and 1 was diagnosed with frontotemporal dementia (FTD) at 0.5 years.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>The likelihood of a patient with SCI developing a neurological diagnosis is reassuringly low (9/166), but not irrelevant. This, along with the benefits of early diagnosis and treatment for dementia, leads us to believe that patients with SCI should still be seen in follow-up at least at the 1-year mark.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.39" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.39" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="26CF547553DFA70828B94C77E1E451E5" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"26CF547553DFA70828B94C77E1E451E5","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="26CF547553DFA70828B94C77E1E451E5" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="182440" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/clinical-study-of-668-indian-subjects-with-juvenile-young-and-early-onset-parkinsons-disease/26CF547553DFA70828B94C77E1E451E5"> Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson’s Disease </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Prashanth L. Kukkle&eventCode=SE-AU" class="more-by-this-author ">Prashanth L. Kukkle</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vinay Goyal&eventCode=SE-AU" class="more-by-this-author ">Vinay Goyal</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Thenral S. Geetha&eventCode=SE-AU" class="more-by-this-author ">Thenral S. Geetha</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kandadai R. Mridula&eventCode=SE-AU" class="more-by-this-author ">Kandadai R. Mridula</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Hrishikesh Kumar&eventCode=SE-AU" class="more-by-this-author ">Hrishikesh Kumar</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rupam Borgohain&eventCode=SE-AU" class="more-by-this-author ">Rupam Borgohain</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Adreesh Mukherjee&eventCode=SE-AU" class="more-by-this-author ">Adreesh Mukherjee</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pettarusp M. Wadia&eventCode=SE-AU" class="more-by-this-author ">Pettarusp M. Wadia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ravi Yadav&eventCode=SE-AU" class="more-by-this-author ">Ravi Yadav</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Soaham Desai&eventCode=SE-AU" class="more-by-this-author ">Soaham Desai</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Niraj Kumar&eventCode=SE-AU" class="more-by-this-author ">Niraj Kumar</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ravi Gupta&eventCode=SE-AU" class="more-by-this-author ">Ravi Gupta</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Atanu Biswas&eventCode=SE-AU" class="more-by-this-author ">Atanu Biswas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pramod K. Pal&eventCode=SE-AU" class="more-by-this-author ">Pramod K. Pal</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Uday Muthane&eventCode=SE-AU" class="more-by-this-author ">Uday Muthane</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Shymal K. Das&eventCode=SE-AU" class="more-by-this-author ">Shymal K. Das</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Niall Quinn&eventCode=SE-AU" class="more-by-this-author ">Niall Quinn</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vedam L. Ramprasad&eventCode=SE-AU" class="more-by-this-author ">Vedam L. Ramprasad</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=the Parkinson Research Alliance of India (PRAI)&eventCode=SE-AU" class="more-by-this-author ">the Parkinson Research Alliance of India (PRAI)</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 March 2021</span><span class="pages">, pp. 93-101</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-26CF547553DFA70828B94C77E1E451E5" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/26CF547553DFA70828B94C77E1E451E5/S0317167121000408a.pdf/clinical_study_of_668_indian_subjects_with_juvenile_young_and_early_onset_parkinsons_disease.pdf" data-pdf-content-id="26CF547553DFA70828B94C77E1E451E5" target="_blank" aria-label="Download PDF for Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson’s Disease [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/26CF547553DFA70828B94C77E1E451E5/core-reader" target="_blank" aria-label="View HTML full text for Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson’s Disease [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"26CF547553DFA70828B94C77E1E451E5","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="26CF547553DFA70828B94C77E1E451E5" data-container="representation" aria-label="Export citation for Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson’s Disease">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000408')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson’s Disease" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"26CF547553DFA70828B94C77E1E451E5"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000408" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objective:</span><p>To determine the demographic pattern of juvenile-onset parkinsonism (JP, <20 years), young-onset (YOPD, 20–40 years), and early onset (EOPD, 40–50 years) Parkinson’s disease (PD) in India.</p></div><div class='sec'><span class="bold">Materials and Methods:</span><p>We conducted a 2-year, pan-India, multicenter collaborative study to analyze clinical patterns of JP, YOPD, and EOPD. All patients under follow-up of movement disorders specialists and meeting United Kingdom (UK) Brain Bank criteria for PD were included.</p></div><div class='sec'><span class="bold">Results:</span><p>A total of 668 subjects (M:F 455:213) were recruited with a mean age at onset of 38.7 ± 8.1 years. The mean duration of symptoms at the time of study was 8 ± 6 years. Fifteen percent had a family history of PD and 13% had consanguinity. JP had the highest consanguinity rate (53%). YOPD and JP cases had a higher prevalence of consanguinity, dystonia, and gait and balance issues compared to those with EOPD. In relation to nonmotor symptoms, panic attacks and depression were more common in YOPD and sleep-related issues more common in EOPD subjects. Overall, dyskinesias were documented in 32.8%. YOPD subjects had a higher frequency of dyskinesia than EOPD subjects (39.9% vs. 25.5%), but they were first noted later in the disease course (5.7 vs. 4.4 years).</p></div><div class='sec'><span class="bold">Conclusion:</span><p>This large cohort shows differing clinical patterns in JP, YOPD, and EOPD cases. We propose that cutoffs of <20, <40, and <50 years should preferably be used to define JP, YOPD, and EOPD.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.40" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.40" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="9A9374A040091AB2AC0322BB6396DF42" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"9A9374A040091AB2AC0322BB6396DF42","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="9A9374A040091AB2AC0322BB6396DF42" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="463156" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/claw-toe-anatomic-guide-for-injection-of-botulinum-toxin-into-foot-muscles/9A9374A040091AB2AC0322BB6396DF42"> Claw Toe: Anatomic Guide for Injection of Botulinum Toxin into Foot Muscles </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Toru Takekawa&eventCode=SE-AU" class="more-by-this-author ">Toru Takekawa</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Satoshi Takagi&eventCode=SE-AU" class="more-by-this-author ">Satoshi Takagi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Tomohide Kitajima&eventCode=SE-AU" class="more-by-this-author ">Tomohide Kitajima</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Tomoharu Sato&eventCode=SE-AU" class="more-by-this-author ">Tomoharu Sato</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kazuo Kinoshita&eventCode=SE-AU" class="more-by-this-author ">Kazuo Kinoshita</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Masahiro Abo&eventCode=SE-AU" class="more-by-this-author ">Masahiro Abo</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 March 2021</span><span class="pages">, pp. 102-108</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-9A9374A040091AB2AC0322BB6396DF42" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a 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class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Poor response to injection of botulinum toxin (BoNT) into the flexor digitorum longus (FDL) muscle has been reported especially in patients with claw foot deformity. We previously advocated BoNT injection into the flexor hallucis longus (FHL) muscle in such patients. Here, we determined the functional and anatomical relationships between FHL and FDL.</p></div><div class='sec'><span class="bold">Methods:</span><p>Toe flexion pattern was observed during electrical stimulation of FHL and FDL muscles in 31 post-stroke patients with claw-foot deformity treated with BoNT. The FHL and FDL tendon arrangement was also studied in five limbs of three cadavers.</p></div><div class='sec'><span class="bold">Results:</span><p>Electrical stimulation of the FHL muscle elicited big toe flexion in all 28 cases examined and second toe in 25, but the response was limited to the big toe in 3. FDL muscle stimulation in 29 patients elicited weak big toe flexion in 1 and flexion of four toes (2nd to 5th) in 16 patients. Cadaver studies showed division of the FHL tendon with branches fusing with the FDL tendon in all five limbs examined; none of the tendons was inserted only in the first toe. No branches of the FDL tendon merged with the FHL tendon.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Our results showed coupling of FHL and FDL tendons in most subjects. Movements of the second and third toes are controlled by both the FDL and FHL muscles. The findings highlight the need for BoNT injection in both the FDL and FHL muscles for the treatment of claw-toe deformity.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.52" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.52" data-link-target="_blank"></div> </div> </div> </div> <div class="representation overview search" data-prod-id="8B258EAABB02721044FC068166EB2C22" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"8B258EAABB02721044FC068166EB2C22","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="8B258EAABB02721044FC068166EB2C22" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="302604" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/factors-associated-with-quality-of-life-in-adults-with-persistent-postconcussion-symptoms/8B258EAABB02721044FC068166EB2C22"> Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Nadejda Popov&eventCode=SE-AU" class="more-by-this-author ">Nadejda Popov</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Leah J. Mercier&eventCode=SE-AU" class="more-by-this-author ">Leah J. Mercier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Regan King&eventCode=SE-AU" class="more-by-this-author ">Regan King</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Tak Fung&eventCode=SE-AU" class="more-by-this-author ">Tak Fung</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Chantel T. Debert&eventCode=SE-AU" class="more-by-this-author ">Chantel T. Debert</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 March 2021</span><span class="pages">, pp. 109-117</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-8B258EAABB02721044FC068166EB2C22" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/8B258EAABB02721044FC068166EB2C22/S0317167121000536a.pdf/factors_associated_with_quality_of_life_in_adults_with_persistent_postconcussion_symptoms.pdf" data-pdf-content-id="8B258EAABB02721044FC068166EB2C22" target="_blank" aria-label="Download PDF for Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/8B258EAABB02721044FC068166EB2C22/core-reader" target="_blank" aria-label="View HTML full text for Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"8B258EAABB02721044FC068166EB2C22","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="8B258EAABB02721044FC068166EB2C22" data-container="representation" aria-label="Export citation for Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167121000536')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Factors Associated with Quality of Life in Adults with Persistent Post-Concussion Symptoms" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"8B258EAABB02721044FC068166EB2C22"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167121000536" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objective:</span><p>To assess demographic, clinical, and injury characteristics associated with health-related quality of life (HRQOL) in adults with persistent post-concussion symptoms (PPCS).</p></div><div class='sec'><span class="bold">Methods:</span><p>Adults with PPCS presenting to a specialized brain injury clinic completed demographic, injury, and clinical outcome questionnaires at the initial clinic assessment. Clinical outcome measures were collected including the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale-7 (GAD-7), and the Fatigue Severity Scale (FSS). HRQOL was measured using the Quality of Life after Brain Injury (QOLIBRI) questionnaire. Stepwise hierarchical multiple regression analysis adjusting for age, sex, and months since injury was used to determine associations between quality of life and clinical outcome measures.</p></div><div class='sec'><span class="bold">Results:</span><p>Overall, 125 participants were included. The PHQ-9, FSS, and GAD-7 were significant predictors of QOLIBRI scores (R<span class='sup'>2</span> = 0.481, p < .001), indicating that participants with higher levels of depressive symptoms, fatigue, and anxiety reported poorer HRQOL. The PHQ-9 score was the strongest predictor, accounting for 42.0% of the variance in QOLIBRI scores. No demographic or injury characteristics significantly predicted QOLIBRI scores. There was a high prevalence of depressive symptoms with 72.8% of participants having PHQ-9 scores ≥ 10.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Among patients with PPCS, mental health and fatigue are important contributors to HRQOL. As there is a high burden of mood disorders and fatigue in this population, targeted treatments for these concerns may impact the quality of life.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.53" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.53" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Neuroimaging Highlight</h4> <div class="representation overview search" data-prod-id="FD6046D2B625904C5247BDC69B2C48E8" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"FD6046D2B625904C5247BDC69B2C48E8","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' name="productParts" style="display: inline-block" data-prod-id="FD6046D2B625904C5247BDC69B2C48E8" data-prod-source="listing" data-prod-type="JOURNAL_ARTICLE" data-file-size="2592113" data-has-entitlement="true" data-has-pdf="true" /> </label> </div> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/symptomatic-internal-carotid-artery-vasa-vasorum-treated-with-surgical-occlusion/FD6046D2B625904C5247BDC69B2C48E8"> Symptomatic Internal Carotid Artery Vasa Vasorum Treated With Surgical Occlusion </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Christine Hawkes&eventCode=SE-AU" class="more-by-this-author ">Christine Hawkes</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Craig Durant&eventCode=SE-AU" class="more-by-this-author ">Craig Durant</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian van Adel&eventCode=SE-AU" class="more-by-this-author ">Brian van Adel</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 March 2021</span><span class="pages">, pp. 118-119</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-FD6046D2B625904C5247BDC69B2C48E8" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/FD6046D2B625904C5247BDC69B2C48E8/S0317167121000494a.pdf/symptomatic_internal_carotid_artery_vasa_vasorum_treated_with_surgical_occlusion.pdf" data-pdf-content-id="FD6046D2B625904C5247BDC69B2C48E8" target="_blank" aria-label="Download PDF for Symptomatic Internal Carotid Artery Vasa Vasorum Treated With Surgical Occlusion [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/FD6046D2B625904C5247BDC69B2C48E8/core-reader" target="_blank" aria-label="View HTML full text for Symptomatic Internal Carotid Artery Vasa Vasorum Treated With Surgical Occlusion [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/journals/canadian-journal-of-neurological-sciences/issue/BAA8043A0188B7311BEC14227EC02492","productId":"FD6046D2B625904C5247BDC69B2C48E8","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); 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Park&eventCode=SE-AU" class="more-by-this-author ">Jung E. 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Six patients underwent onabotulinum toxin A injection and were assessed by Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin’s effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.42" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2021.42" data-link-target="_blank"></div> </div> </div> </div> <h4 class="journal-article-listing-type heading_12 margin-bottom">Practice Pearls</h4> <div class="representation overview search" data-prod-id="5BCA95637A282852F75CEBAA89053381" data-mathjax-disabled="true"> <div class="row"> <div class="small-1 columns checklist-col"> <label 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Micro-Arteriovenous Fistulae </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Marlise P. dos Santos&eventCode=SE-AU" class="more-by-this-author ">Marlise P. dos Santos</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Charles Haw&eventCode=SE-AU" class="more-by-this-author ">Charles Haw</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Fabio Settecase&eventCode=SE-AU" class="more-by-this-author ">Fabio Settecase</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jason Chew&eventCode=SE-AU" class="more-by-this-author ">Jason Chew</a> </li> <li> <dl> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 26 March 2021</span><span class="pages">, pp. 129-132</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li 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Canadian Journal of Neurological Sciences: Volume 49 - Issue 1 | Cambridge Core