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{"work":{"id":109720158,"created_at":"2023-11-24T03:07:02.960-08:00","from_world_paper_id":243862666,"updated_at":"2024-11-24T17:01:56.760-08:00","_data":{"grobid_abstract":"In the present study, a review of the literature that examines the widely used clinical applications of Forced Oscillation Technique (FOT) and Impulse Oscillometry (IOS) is attempted, in order to evaluate the contribution of the method to laboratory lung function testing. The typical modifications of respiratory impedance components and their diagnostic value are pointed out, as well as the parameters of optimal validity towards pathophysiology survey, but also the evaluation of effectiveness of treatment, for chronic obstructive pulmonary disease and bronchial asthma, in stable disease and exacerbations. Moreover, the current data to evaluate upper intrathoracic and extrathoracic airways obstruction is presented, but also to evaluate the state of diseases with restrictive and mixed (obstructive/restrictive) pathophysiology. Finally, there is an individual report about the correlation between the frequency and the intensity of abnormal oscillometric indices and common signs and symptoms of patients suffering from above diseases, but also the correlation between these indices and established values of spirometry and body-plythesmography. 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const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=109720158"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">In the present study, a review of the literature that examines the widely used clinical applications of Forced Oscillation Technique (FOT) and Impulse Oscillometry (IOS) is attempted, in order to evaluate the contribution of the method to laboratory lung function testing. The typical modifications of respiratory impedance components and their diagnostic value are pointed out, as well as the parameters of optimal validity towards pathophysiology survey, but also the evaluation of effectiveness of treatment, for chronic obstructive pulmonary disease and bronchial asthma, in stable disease and exacerbations. Moreover, the current data to evaluate upper intrathoracic and extrathoracic airways obstruction is presented, but also to evaluate the state of diseases with restrictive and mixed (obstructive/restrictive) pathophysiology. Finally, there is an individual report about the correlation between the frequency and the intensity of abnormal oscillometric indices and common signs and symptoms of patients suffering from above diseases, but also the correlation between these indices and established values of spirometry and body-plythesmography. In this review, studies on pediatric populations are not included and all the data referred to, concern adult patients.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":107760591,"attachmentType":"pdf","workUrl":"https://www.academia.edu/109720158/Forced_Oscillations_in_Applied_Respiratory_Physiology_Clinical"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":107760591,"attachmentType":"pdf","workUrl":"https://www.academia.edu/109720158/Forced_Oscillations_in_Applied_Respiratory_Physiology_Clinical"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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The typical modifications of respiratory impedance components and their diagnostic value are pointed out, as well as the parameters of optimal validity towards pathophysiology survey, but also the evaluation of effectiveness of treatment, for chronic obstructive pulmonary disease and bronchial asthma, in stable disease and exacerbations. Moreover, the current data to evaluate upper intrathoracic and extrathoracic airways obstruction is presented, but also to evaluate the state of diseases with restrictive and mixed (obstructive/restrictive) pathophysiology. Finally, there is an individual report about the correlation between the frequency and the intensity of abnormal oscillometric indices and common signs and symptoms of patients suffering from above diseases, but also the correlation between these indices and established values of spirometry and body-plythesmography. In this review, studies on pediatric populations are not included and all the data referred to, concern adult patients.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Forced oscillations in applied respiratory physiology: Clinical Applications","attachmentId":77294953,"attachmentType":"pdf","work_url":"https://www.academia.edu/65895186/Forced_oscillations_in_applied_respiratory_physiology_Clinical_Applications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65895186/Forced_oscillations_in_applied_respiratory_physiology_Clinical_Applications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="47725722" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/47725722/Lung_Function_Assessment_by_Impulse_Oscillometry_in_Adults">Lung Function Assessment by Impulse Oscillometry in Adults</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="174375818" href="https://independent.academia.edu/NPorojanSuppini">Noemi Porojan-Suppini</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="192015189" href="https://independent.academia.edu/MonicaMarc3">Monica Marc</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57816380" href="https://independent.academia.edu/OvidiuFiraMladinescu">Ovidiu Fira-Mladinescu</a></div><p class="ds-related-work--metadata ds2-5-body-xs"> Therapeutics and Clinical Risk Management, 2020</p><p class="ds-related-work--abstract ds2-5-body-sm">Over the past decades, impulse oscillometry (IOS) has gained ground in the battery of pulmonary function tests. Performing the test requires minimal cooperation of the patient; therefore, it is a useful tool, especially in evaluating lung mechanics in children, elderly patients, and those who cannot perform spirometry. Oscillometry has also been used in both clinical and research departments. Studies were published mainly in asthma regarding detection of bronchodilator response and the therapeutic response to different drugs. Furthermore, it has been shown to be a sensitive technique to evaluate disease control. Other studied diseases were COPD, interstitial lung diseases, small airway disease, impairment of lung function due to exposure to occupational hazards or smoking, central airways obstruction, cystic fibrosis, monitoring lung mechanics during mechanical ventilation and sleep, neuromuscular diseases, lung transplant, and graft function. The aim of this review is to present the utility of oscillometry on the previously mentioned clinical fields.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lung Function Assessment by Impulse Oscillometry in Adults","attachmentId":66673272,"attachmentType":"pdf","work_url":"https://www.academia.edu/47725722/Lung_Function_Assessment_by_Impulse_Oscillometry_in_Adults","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/47725722/Lung_Function_Assessment_by_Impulse_Oscillometry_in_Adults"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="5172129" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5172129/Detection_of_changes_in_respiratory_mechanics_due_to_increasing_degrees_of_airway_obstruction_in_asthma_by_the_forced_oscillation_technique">Detection of changes in respiratory mechanics due to increasing degrees of airway obstruction in asthma by the forced oscillation technique</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7008009" href="https://unirio.academia.edu/PedroLopes">Pedro Lopes</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Respiratory Medicine, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Forced expiratory airflows and volumes are often used to assess the airway obstruction in asthmatics. However, forced maneuvers may change bronchial tone and modify airway patency. The aim of this study was to determine whether the Forced Oscillation Technique (FOT), which does not require forced manoeuvres, may be useful to describe the changes in respiratory mechanics in progressive asthma. This study involved 25 healthy and 84 asthmatics, including patients with normal spirometric exam (NE), mild moderate and severe obstruction. Resistive data were interpreted using the respiratory system resistance extrapolated at 0 Hz (R0), the mean respiratory resistance (Rm), and the resistance/frequency slope (S). Reactance data were interpreted by its mean values (Xm), the dynamic compliance (Crs,dyn), and resonant frequency (fr). Receiver operating characteristics curves were used to determine the sensitivity (Se) and specificity (Sp) of FOT parameters in identifying asthma.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Detection of changes in respiratory mechanics due to increasing degrees of airway obstruction in asthma by the forced oscillation technique","attachmentId":49418309,"attachmentType":"pdf","work_url":"https://www.academia.edu/5172129/Detection_of_changes_in_respiratory_mechanics_due_to_increasing_degrees_of_airway_obstruction_in_asthma_by_the_forced_oscillation_technique","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5172129/Detection_of_changes_in_respiratory_mechanics_due_to_increasing_degrees_of_airway_obstruction_in_asthma_by_the_forced_oscillation_technique"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="121814031" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/121814031/Impulse_oscillometry_as_an_alternative_modality_to_the_conventional_pulmonary_function_tests_in_chronic_obstructive_pulmonary_disease">Impulse oscillometry as an alternative modality to the conventional pulmonary function tests in chronic obstructive pulmonary disease</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="181203148" href="https://independent.academia.edu/SherifNabhanMohamadTawfickaddah">Sherif Nabhan Mohamad Tawfic kaddah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Egyptian Journal of Chest Diseases and Tuberculosis, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Impulse oscillometry as an alternative modality to the conventional pulmonary function tests in chronic obstructive pulmonary disease","attachmentId":116607487,"attachmentType":"pdf","work_url":"https://www.academia.edu/121814031/Impulse_oscillometry_as_an_alternative_modality_to_the_conventional_pulmonary_function_tests_in_chronic_obstructive_pulmonary_disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/121814031/Impulse_oscillometry_as_an_alternative_modality_to_the_conventional_pulmonary_function_tests_in_chronic_obstructive_pulmonary_disease"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="126826182" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/126826182/The_utility_of_impulse_oscillometry_in_asthma_A_comparison_of_spirometry_versus_impulse_oscillometry_system">The utility of impulse oscillometry in asthma: A comparison of spirometry versus impulse oscillometry system</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="206479326" href="https://independent.academia.edu/ragiasharshar">ragia sharshar</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Egyptian Journal of Chest Diseases and Tuberculosis, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Spirometry and body plethysmography have been routinely used for measuring pulmonary function. Impulse oscillometry (IOS) is a variant of forced oscillation technique based on physiologic concepts that were first described almost 50 years ago are emerging in research and in clinical practice. Objective: To evaluate IOS usefulness in patients with asthma. Methodology: This study conducted on 50 patients with a diagnosis of asthma who were classified into two groups, mild-moderate and severe. Spirometry and IOS were performed before and after three months of treatment. Conclusion: Impulse oscillometry provides an easily, rapid tool to diagnose and classify airway obstructive severity in asthma.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The utility of impulse oscillometry in asthma: A comparison of spirometry versus impulse oscillometry system","attachmentId":120646110,"attachmentType":"pdf","work_url":"https://www.academia.edu/126826182/The_utility_of_impulse_oscillometry_in_asthma_A_comparison_of_spirometry_versus_impulse_oscillometry_system","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/126826182/The_utility_of_impulse_oscillometry_in_asthma_A_comparison_of_spirometry_versus_impulse_oscillometry_system"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="12745739" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12745739/The_utility_of_the_forced_oscillation_technique_in_assessing_bronchodilator_responsiveness_in_patients_with_asthma">The utility of the forced oscillation technique in assessing bronchodilator responsiveness in patients with asthma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31785167" href="https://nyu.academia.edu/MichaelAkerman">Michael Akerman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Respiratory Medicine, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective: To address the utility of the forced oscillation technique (FOT) in assessing bronchodilator responsiveness compared with forced expiratory volume in 1 s (FEV 1 ). Methods: This is a retrospective analysis of consecutive 126 patients with a clinical history of asthma without any other lung diseases at a pulmonary function testing laboratory. The following measurements were obtained three times each, before and after two doses of pirbuterol 0.2 mg inhalation: the respiratory resistance at 5 Hz (Rrs5), the mean respiratory resistance between 5 and 20 Hz (Rrs5-20), and the mean respiratory conductance (Grs5-20) by FOT and the FEV 1 by spirometer. These measurements were transformed into dimensionless subject-specific effect-size ''d-scores'' by dividing them by the estimated pooled within-subject standard deviation. Results: Descriptive statistics for each value were the following [mean baseline value (7SD), D value (pre-minus post value), and d-score (P value compared to FEV 1 )]: Grs5-20</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The utility of the forced oscillation technique in assessing bronchodilator responsiveness in patients with asthma","attachmentId":45965834,"attachmentType":"pdf","work_url":"https://www.academia.edu/12745739/The_utility_of_the_forced_oscillation_technique_in_assessing_bronchodilator_responsiveness_in_patients_with_asthma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12745739/The_utility_of_the_forced_oscillation_technique_in_assessing_bronchodilator_responsiveness_in_patients_with_asthma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="89751053" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89751053/Impulse_oscillometry_to_differentiate_between_chronic_obstructive_pulmonary_disease_and_bronchial_asthma">Impulse oscillometry to differentiate between chronic obstructive pulmonary disease and bronchial asthma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="147547969" href="https://independent.academia.edu/EsraaMohammed46">Esraa Mohammed</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Egyptian Journal of Bronchology, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Background The impulse oscillation system (IOS) yields useful clinical data that predominantly include functional assessment of peripheral airways more than that available from commonly used spirometry. The aim of this study was to differentiate between chronic obstructive pulmonary disease (COPD) and bronchial asthma using IOS. Patients and methods This study was carried out on 40 patients; 20 patients were diagnosed with bronchial asthma and the remaining 20 patients had a clinical diagnosis of COPD. All patients underwent baseline IOS and spirometry, and then after 15 min of inhalation of 400 μg salbutamol, spirometry was repeated in all patients. Results A highly statistically significant difference was found between asthma patients and COPD patients in R20, whereas no statistically significant difference was found between the two studied groups in R5, X5. There was a statistically significant difference between asthma patients and COPD patients in resistance; 75% of asthmatic p...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Impulse oscillometry to differentiate between chronic obstructive pulmonary disease and bronchial asthma","attachmentId":93506259,"attachmentType":"pdf","work_url":"https://www.academia.edu/89751053/Impulse_oscillometry_to_differentiate_between_chronic_obstructive_pulmonary_disease_and_bronchial_asthma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/89751053/Impulse_oscillometry_to_differentiate_between_chronic_obstructive_pulmonary_disease_and_bronchial_asthma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="15241019" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15241019/Evaluation_of_impulse_oscillometry_during_bronchial_challenge_testing_in_children">Evaluation of impulse oscillometry during bronchial challenge testing in children</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34312118" href="https://independent.academia.edu/DominiqueCrenesse">Dominique Crenesse</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatric Pulmonology, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: The impulse oscillation system (IOS) allows easy measurement of respiratory system impedance (Zrs). The aim of this retrospective study was to evaluate the accuracy of IOS parameters obtained during methacholine challenge by comparison with ''the gold standard'' forced expiratory volume in the first second (FEV 1 ). Methods: Measurements of FEV 1 and resistances at 5 and 20 Hz, reactance at 5 Hz, impedance at 5 Hz and resonant frequency were performed in 227 children with suspected asthma, before and during methacholine challenge. Data were analyzed in the overall population and in three subgroups according to the final diagnosis: asthma (n ¼ 72), chronic cough and nonspecific respiratory symptoms (n ¼ 122), allergic rhinitis (n ¼ 33). Results: All IOS parameters changed significantly during the tests but only changes in X5 were significantly different between responders and nonresponders. Moreover, changes in IOS parameters were not correlated with changes in FEV 1 apart from a weak correlation for X5. The receiver operating characteristic (ROC) curve for changes in X5 (to predict a 20% decrease in FEV 1 ) showed a best decision level for a 50% decrease in X5 with a sensitivity of 36% and a specificity of 85%. Results were not different in the asthma group. Conclusion: The accuracy of measurements by IOS during methacholine bronchial challenge in children was not suitable when compared with FEV 1 . It could be assumed that spirometry and IOS, while both providing indirect indices of airway patency, are exploring different mechanisms, each with its own methodological potentials and limitations.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of impulse oscillometry during bronchial challenge testing in children","attachmentId":43406969,"attachmentType":"pdf","work_url":"https://www.academia.edu/15241019/Evaluation_of_impulse_oscillometry_during_bronchial_challenge_testing_in_children","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15241019/Evaluation_of_impulse_oscillometry_during_bronchial_challenge_testing_in_children"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="14536630" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14536630/A_study_of_the_use_of_impulse_oscillometry_in_the_evaluation_of_children_with_asthma_Analysis_of_lung_parameters_order_effect_and_utility_compared_with_spirometry">A study of the use of impulse oscillometry in the evaluation of children with asthma: Analysis of lung parameters, order effect, and utility compared with spirometry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33548251" href="https://independent.academia.edu/HirshKomarow">Hirsh Komarow</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33496358" href="https://independent.academia.edu/PeterGergen">Peter Gergen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatric Pulmonology, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Background-The ability to objectively measure lung function in children is critical in the assessment and treatment of asthma in this age group. We thus determined the effectiveness of impulse oscillometry (IOS) as a non-invasive technique to assess lung function in children and in comparison to spirometry for sensitivity and specificity, testing variability, and the order effect of sequential testing of IOS and spirometry.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A study of the use of impulse oscillometry in the evaluation of children with asthma: Analysis of lung parameters, order effect, and utility compared with spirometry","attachmentId":44085350,"attachmentType":"pdf","work_url":"https://www.academia.edu/14536630/A_study_of_the_use_of_impulse_oscillometry_in_the_evaluation_of_children_with_asthma_Analysis_of_lung_parameters_order_effect_and_utility_compared_with_spirometry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14536630/A_study_of_the_use_of_impulse_oscillometry_in_the_evaluation_of_children_with_asthma_Analysis_of_lung_parameters_order_effect_and_utility_compared_with_spirometry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="77598206" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77598206/_p_Comparison_of_impedance_measured_by_the_forced_oscillation_technique_and_pulmonary_functions_including_static_lung_compliance_in_obstructive_and_interstitial_lung_disease_p_"><p>Comparison of impedance measured by the forced oscillation technique and pulmonary functions, including static lung compliance, in obstructive and interstitial lung disease</p></a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="221858051" href="https://independent.academia.edu/Jos%C3%A9%C3%81ngelG%C3%B3mez2">José Ángel Gómez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Chronic Obstructive Pulmonary Disease, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective: To examine whether the parameters of impedance measured by the broadband frequency forced oscillation technique (FOT) were reflected by changes in lung compliance induced by emphysema and fibrosis, we retrospectively compared the parameters of FOT and pulmonary functions, including static lung compliance (Cst), in obstructive lung disease (OLD) and interstitial lung disease (ILD). Patients and methods: The data of 18 patients with OLD (16 with COPD, two with asthma COPD overlap), 11 with ILD, and 24 healthy volunteers, whose respiratory impedance was measured using a MostGraph-01 and other pulmonary functions including Cst and lung resistance (R L) were measured on the same day and were retrospectively collected and compared. Results: The parameters of resistance, reactance, and resonant frequency showed good correlations with ventilation unevenness (r=0.63, −0.89, 0.77, respectively) and lung elastic resistance (r=0.59, −0.80, 0.73, respectively) in all groups (N=53). These indices were significant determinants of increased respiratory resistance and more negative shift of respiratory reactance (Xrs) at lower frequency (P<0.001). Decreased functional residual capacity was also a determinant of Xrs at 5 Hz (X5) (P<0.05). The differences in mean X5 in the expiratory phase relative to those in the inspiratory phase (within-breath changes in X5) were associated with airflow obstruction (P<0.002) and lung elastic resistance (P<0.001). However, no significant correlations between Cst and any parameters of respiratory impedance were observed. Conclusions: These findings suggest that the impedance parameters measured by FOT are reflected by airway obstruction, ventilation unevenness, and lung resistance, but hardly reflected by changes in lung compliance due to emphysema or fibrosis in both CLD and ILD.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"\u003cp\u003eComparison of impedance measured by the forced oscillation technique and pulmonary functions, including static lung compliance, in obstructive and interstitial lung disease\u003c/p\u003e","attachmentId":84871854,"attachmentType":"pdf","work_url":"https://www.academia.edu/77598206/_p_Comparison_of_impedance_measured_by_the_forced_oscillation_technique_and_pulmonary_functions_including_static_lung_compliance_in_obstructive_and_interstitial_lung_disease_p_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/77598206/_p_Comparison_of_impedance_measured_by_the_forced_oscillation_technique_and_pulmonary_functions_including_static_lung_compliance_in_obstructive_and_interstitial_lung_disease_p_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":107760591,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":107760591,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_107760591" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="124071846" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124071846/Forced_Oscillation_Technique_Fot_a_Novel_Method_for_the_Detection_of_Early_Airway_Changes">Forced Oscillation Technique (Fot) – a Novel Method for the Detection of Early Airway Changes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36276288" href="https://independent.academia.edu/StoilkaMandadzhieva">Stoilka Mandadzhieva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medis, 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style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="14558522" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14558522/Changes_in_respiratory_mechanics_with_increasing_degrees_of_airway_obstruction_in_COPD_Detection_by_forced_oscillation_technique">Changes in respiratory mechanics with increasing degrees of airway obstruction in COPD: Detection by forced oscillation technique</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33521885" href="https://sportsinbrazil.academia.edu/AgnaldoLopes">Agnaldo Lopes</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Respiratory Medicine, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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js-related-work-sidebar-card" data-collection-position="3" data-entity-id="103781939" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103781939/The_Use_and_Interpretation_of_Impedance_Oscillometry_in_Pulmonary_Disorders">The Use and Interpretation of Impedance Oscillometry in Pulmonary Disorders</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="274761929" href="https://independent.academia.edu/AlexanderDuarte67">Alexander Duarte</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Current Pulmonology Reports, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Use and Interpretation of Impedance Oscillometry in Pulmonary 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