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Whether you want to evaluate your KRAS-targeted compound\u2019s effect on previously radiated tumors <em>in vitro<\/em>, test it against immunotherapy-resistant subtypes <em>in vivo<\/em>, or investigate tumor microenvironment activity in humanized orthotopic patient-derived xenograft (O-PDX) cancer models, we support your forward-thinking approach to better translational data.<\/p>\n","cta":{"title":"LEARN MORE","url":"https:\/\/www.certisoncology.com\/kras-targeted-oncology-drug-development\/","target":""}}],"media-option":"image","image":{"image":{"ID":5985,"id":5985,"title":"Cancer-Models_RAS-Infographic-optimized","filename":"Cancer-Models_RAS-Infographic-optimized.webp","filesize":13292,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/cancer-models_ras-infographic-optimized\/","alt":"Cancer-Models_RAS-Infographic","author":"6","description":"Cancer-Models_RAS-Infographic","caption":"Cancer-Models_RAS-Infographic","name":"cancer-models_ras-infographic-optimized","status":"inherit","uploaded_to":221,"date":"2024-01-23 18:26:33","modified":"2024-01-23 18:26:45","menu_order":0,"mime_type":"image\/webp","type":"image","subtype":"webp","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":720,"height":540,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized-150x150.webp","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","medium-width":300,"medium-height":225,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","medium_large-width":720,"medium_large-height":540,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","large-width":720,"large-height":540,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","1536x1536-width":720,"1536x1536-height":540,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","2048x2048-width":720,"2048x2048-height":540,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized-540x405.webp","small-width":540,"small-height":405,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized-540x540.webp","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","square-md-width":720,"square-md-height":540,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized-640x540.webp","portrait-width":640,"portrait-height":540,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_RAS-Infographic-optimized.webp","landscape-width":720,"landscape-height":540}},"href":{"title":"Learn More","url":"https:\/\/www.certisoncology.com\/kras-targeted-oncology-drug-development]","target":"_blank"},"title":" Validating KRAS-Targeting Strategies","description":"<p>Our tumor bank includes 56 unique PDX models and companion PDX-derived 3D cell cultures with the most common RAS mutations in cancer, including lung, colorectal, and pancreatic.<\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"gray","direction":"right to left","vertical-align":"top"}}"></component-5f7cbffb57673><component-5f6e3c3648fee :arr="{"headline":"","content":"<h2>Tackling GBM Research Challenges Together<\/h2>\n<p>Research shows that on average, 9 out of 10 glioblastoma therapeutics fail in phase III clinical trials.<span class=\"tooltip\"><sup id=\"6014\">2<\/sup><\/span> Which is why it\u2019s important to invest in scalable and reproducible preclinical data upfront. Whether its biomarker discovery and validation, dosing and delivery optimization for single and\/or combinatorial therapies, or intracranial orthoptic <em>in vivo<\/em> studies to test the efficacy of your compounds, Certis can help bring greater certainty around go\/no-go GBM drug development decisions.<\/p>\n<p>High throughput screening of our patient-derived GBM tumorspheres \u2013 advanced 3D cell culture systems \u2013 is rapid, cost-effective and physiologically relevant. Learn about innovations in GBM model development and download our GBM data summary.<\/p>\n","cta":{"title":"VIEW GBM MODELS","url":"https:\/\/www.certisoncology.com\/innovations-in-glioblastoma-mouse-model-development\/","target":""},"media-option":"image","image":{"image":{"ID":7035,"id":7035,"title":"Cancer-Models_GBM-3D-Spheroid-reoptimized","filename":"Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","filesize":52207,"url":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","link":"https:\/\/www.certisoncology.com\/for-drug-developers\/cancer-models-preclinical-studies\/cancer-models_gbm-3d-spheroid-reoptimized\/","alt":"","author":"6","description":"","caption":"","name":"cancer-models_gbm-3d-spheroid-reoptimized","status":"inherit","uploaded_to":221,"date":"2024-02-22 21:39:46","modified":"2024-02-22 21:39:46","menu_order":0,"mime_type":"image\/jpeg","type":"image","subtype":"jpeg","icon":"https:\/\/www.certisoncology.com\/wp-includes\/images\/media\/default.png","width":721,"height":603,"sizes":{"thumbnail":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized-150x150.jpg","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","medium-width":300,"medium-height":251,"medium_large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","medium_large-width":721,"medium_large-height":603,"large":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","large-width":721,"large-height":603,"1536x1536":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","1536x1536-width":721,"1536x1536-height":603,"2048x2048":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","2048x2048-width":721,"2048x2048-height":603,"small":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized-540x452.jpg","small-width":540,"small-height":452,"square-sm":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized-540x540.jpg","square-sm-width":540,"square-sm-height":540,"square-md":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","square-md-width":720,"square-md-height":602,"portrait":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized-640x603.jpg","portrait-width":640,"portrait-height":603,"landscape":"https:\/\/www.certisoncology.com\/wp-content\/uploads\/Cancer-Models_GBM-3D-Spheroid-reoptimized.jpg","landscape-width":721,"landscape-height":603}},"href":"","title":"3D Patient-Derived GBM Tumorspheres","description":"<p>This image from Certis shows a PDX-derived 3D cell culture from a 54-year-old female with a treatment-na\u00efve primary brain tumor. <\/p>\n"},"video-service":"","video":{"id":"","title":"","description":""},"layout":{"background-color":"white","direction":"left to right","vertical-align":"top"}}"></component-5f6e3c3648fee><component-5f6e424bba9c9 :arr="{"headline":"The Story Behind BarneyOI","description":"<p style=\"text-align: left;\">The story behind the BarneyOI Cancer Model Database begins with a son named Barney who was diagnosed with an aggressive form of liposarcoma, and a frustrated father named Jim who was determined to seek cancer treatment options beyond the standard of care.<\/p>\n","cta":{"title":"READ MORE","url":"http:\/\/certisoncology.com\/about-us\/our-story\/","target":""},"layout":{"background":"cells","style":"default","sticky":false}}"></component-5f6e424bba9c9><component-5f6e40ba1bdc4 :arr="{"title":" ","content":"","headline":"BarneyOI Cancer Model Database: Answers to Frequently Asked Question","items":[{"ID":3372,"post_author":"6","post_date":"2021-09-17 19:25:08","post_date_gmt":"2021-09-17 19:25:08","post_content":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<p><a href=\"https:\/\/www.certisoncology.com\/for-drug-developers\/tumor-bank\/\">Requesting access <\/a>to the BarneyOI Cancer Model Database is easy \u2014just provide your company email address. Access to BarneyOI is generally granted within 24 hours and our scientists are available to answer questions and perform custom queries.<\/p>\n\n\n\n<p>Email <a href=\"mailto:busdev@certisoncology.com\" target=\"_blank\" rel=\"noreferrer noopener\">busdev@certisoncology.com<\/a> for database access, custom queries and any patient-derived xenograft (PDX)-related questions.<\/p>\n<\/div>\n<\/div>\n","post_title":"How do I gain access to the BarneyOI Cancer Model Database?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-i-gain-access-to-the-certis-tumor-bank","to_ping":"","pinged":"","post_modified":"2024-02-16 18:40:37","post_modified_gmt":"2024-02-16 18:40:37","post_content_filtered":"","post_parent":3384,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3372","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3373,"post_author":"6","post_date":"2021-09-17 19:18:30","post_date_gmt":"2021-09-17 19:18:30","post_content":"\n<p>Just use the convenient search and filter functions. The BarneyOI Cancer Model Database is one central, intuitive, responsive online interface that is easy to navigate to find the right PDX model for your preclinical investigation. With BarneyOI, you can:<\/p>\n\n\n\n<p>Fine-tune your custom keyword search with easy-to-use preset filters<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Drill down deep into genomic profiles using additive gene filters<\/li>\n\n\n\n<li>Easily compare gene expression results to matched disease-free tissue<\/li>\n\n\n\n<li>Obtain a detailed model profile of patient and tumor model characteristics<\/li>\n\n\n\n<li>View interactive graphical representations of model sets<\/li>\n\n\n\n<li>Export and share your selected analysis<\/li>\n<\/ul>\n\n\n\n<p>With the BarneyOI Cancer Model Database, you can easily search and select <em>in vivo<\/em> (orthotopic models and subcutaneous mouse models) and <em>in vitro<\/em> (3D cell cultures and cell line-derived xenograft) CDX models from the Certis tumor bank. You\u2019ll find robust characterization data that faithfully represent each model\u2019s unique genetic and biologic features. Watch this comprehensive <a href=\"https:\/\/share.vidyard.com\/watch\/5UZ2982LNAnE4JpUSiecSM?\" target=\"_blank\" rel=\"noreferrer noopener\">video tutorial<\/a> to learn how to take full advantage of the enhanced search functionality of our database.<\/p>\n","post_title":"How do I search the BarneyOI Cancer Model Database?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-i-search-the-certis-tumor-bank","to_ping":"","pinged":"","post_modified":"2024-07-22 15:53:20","post_modified_gmt":"2024-07-22 15:53:20","post_content_filtered":"","post_parent":3384,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3373","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3376,"post_author":"6","post_date":"2021-09-17 19:32:20","post_date_gmt":"2021-09-17 19:32:20","post_content":"\n<p>Every model undergoes a rigorous quality control process:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>WES and RNAseq data from each PDX, CDX and PDX-derived cell line model in the Certis tumor bank is analyzed by our bioinformatics team to confirm genetic fidelity of the model over serial passaging. The quality and concordance of Certis\u2019 cancer models with TCGA ensure consistency and certainty, providing drug developers with clinically relevant models for cancer research.<\/li>\n\n\n\n<li>We apply spectral flow cytometry and immunohistochemistry techniques to verify the murine content in all of our cancer models.<\/li>\n\n\n\n<li>The Certis in-house data science team conducts regular quality control checks of the tumor bank. Our data scientists review gene coverage and remove murine contamination where applicable.<\/li>\n<\/ul>\n","post_title":"How do you ensure the quality and accuracy of your cancer models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-you-ensure-the-quality-and-accuracy-of-in-vitro-cell-lines-and-in-vivo-models-in-the-certis-tumor-bank","to_ping":"","pinged":"","post_modified":"2024-02-16 18:44:56","post_modified_gmt":"2024-02-16 18:44:56","post_content_filtered":"","post_parent":3384,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3376","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3377,"post_author":"6","post_date":"2021-09-17 19:41:15","post_date_gmt":"2021-09-17 19:41:15","post_content":"\n<p>BarneyOI provides a wide variety of details about each model, including the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Patient characteristics (gender, HLA status and prior treatment – for some specimens, the donor patient’s full treatment history is available)<\/li>\n\n\n\n<li>Tumor characteristics (disease stage, disease grade, cancer type, cancer subtype, model type, tumor site, model ID)<\/li>\n\n\n\n<li>Primary\/Metastasis, with links to related models<\/li>\n\n\n\n<li>Tumor engraftment details (sample type, mouse strain, implantation site, tumor growth curves)<\/li>\n\n\n\n<li>Pharmacology study results<\/li>\n\n\n\n<li>Histology staining slides<\/li>\n\n\n\n<li>MRI imaging<\/li>\n\n\n\n<li>Genomic Analysis (expression levels, mutations, gene fusions copy number variations)<\/li>\n\n\n\n<li><em>In vitro<\/em> pharmacology<\/li>\n<\/ul>\n\n\n\n<p><span class=\"TextRun SCXW106343581 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW106343581 BCX0\">Whether your ideal model is na\u00efve or pretreated, primary or metastatic, orthotopic or heterotopic PDX or cell culture, developing clinically relevant models and providing a smarter way to find them is one more way Certis delivers Oncology Intelligence.<\/span> <\/span><\/p>\n","post_title":"What kind of characterization data is available on your PDX cancer models?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"what-kind-of-characterization-data-is-available-on-tumors-in-the-certis-tumor-bank","to_ping":"","pinged":"","post_modified":"2024-02-16 18:45:43","post_modified_gmt":"2024-02-16 18:45:43","post_content_filtered":"","post_parent":3384,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3377","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3370,"post_author":"6","post_date":"2021-09-17 18:38:48","post_date_gmt":"2021-09-17 18:38:48","post_content":"\n<p>Unlike many contract research organizations (CRO)s, Certis has developed its commercial cancer models from tissue derived from North American patients. Some models originate from personalized studies Certis has conducted for individual patients; others are developed from tissues or research models acquired through alliances with research institutions. Most models in the Certis tumor bank have been developed from tissue acquired within the last five years and many have been pretreated with current standard-of-care therapies.<\/p>\n","post_title":"Where does Certis source tissues for developing its PDX tumor bank?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"where-does-certis-source-tissues-for-developing-its-pdx-tumor-bank","to_ping":"","pinged":"","post_modified":"2024-02-16 18:46:21","post_modified_gmt":"2024-02-16 18:46:21","post_content_filtered":"","post_parent":3384,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=3370","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":5991,"post_author":"6","post_date":"2024-01-23 18:34:51","post_date_gmt":"2024-01-23 18:34:51","post_content":"\n<p>3D cancer models, including 3D cell cultures and organoids can be manipulated for preclinical drug discovery and <em>in vitro<\/em> model development. Generally, 3D cell cultures maintain several aspects of <em>in vivo <\/em>cell and tumor growth and have enabled drug developers to better bridge the gap between <em>in vitro<\/em> and<em> in vivo<\/em> studies. In 3D cell cultures, the tumor is dissociated into single-cell suspension and cultured in media as a monoculture or with other cell types. Tumor organoids, on the other hand, mimic organ organization and arise from adult, embryonic, or induced pluripotent stem cells, and are generally regarded as a complement to <em>in vivo<\/em> testing.<\/p>\n","post_title":"How do Certis\u2019 3D spheroidal cell cultures compare with organoids?","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"how-do-certis-3d-spheroidal-cell-cultures-compare-with-organoids","to_ping":"","pinged":"","post_modified":"2024-01-23 18:34:52","post_modified_gmt":"2024-01-23 18:34:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/www.certisoncology.com\/?post_type=type-faqs&p=5991","menu_order":0,"post_type":"type-faqs","post_mime_type":"","comment_count":"0","filter":"raw"}],"cta":"","layout":{"background":"","background-offset":""}}"></component-5f6e40ba1bdc4><component-5f6e424bba9c9 :arr="{"headline":"How Can We Help?","description":"","cta":{"title":"Contact Us","url":"https:\/\/www.certisoncology.com\/contact-us\/","target":""},"layout":{"background":"cells","style":"default","sticky":true}}"></component-5f6e424bba9c9> </div> <footer> <div class="container"> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="mb-4 mb-md-2 mb-lg-0 mr-sm-4"> <figure class="mb-3 mr-lg-6"> <img class="img-fluid d-block" src="/wp-content/themes/certis/images/certis-logo-lockup-white.svg"> </figure> <address> <div> <span class="street-address d-block">5626 Oberlin Drive, Suite 110</span> <span class="city state zip d-block mb-3">San Diego, CA 92121</span> </div> <div> <span class="phone d-block">Drug Development: 858-988-1033</span> <span class="phone d-block">Patients & Oncologists: 858-228-4110</span> <span class="phone d-block">Main: 858-952-1820</span> </div> </address> </div> <nav class="flex-grow-1"> <ul class="sections ml-0 ml-md-4"> <li> <h4 style="text-transform: uppercase;">Drug Developers</h4> <ul class="child-pages"> <li><a 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