Pragmatic Studies for Pain Management Without Opioids

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<div class="container"> <a id="main-content" tabindex="-1"></a> <div class="row"> <div class="col-sm-12 breadcrumb-col col-md-7"> <div id="block-particle-breadcrumbs"> <nav aria-label="breadcrumb" role="navigation"> <ol class="breadcrumb"> <li class="breadcrumb-item gtm-breadcrumb"><a href="/" class="gtm-breadcrumb">Home</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research" class="gtm-breadcrumb">Research</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research/clinical-research" class="gtm-breadcrumb">Clinical Research In Pain Management</a></li> <li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)</li> </ol> </nav> </div> </div> <div class="col-sm-12 col-md-5"> </div> </div> </div> <div class="layout-content"> <div> <div id="block-particle-content"> <h1> Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) </h1> <div> <div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> <div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-2a2fb27407b3a88270f13089068fc3784da98a25c2817d4010441b988cacc802"> <div id="carousel-1429047459" class="callout carousel slide" data-ride="carousel"> <button type=button class="btn carousel-pause" target="" > <span class="pause-icon"></span> </button> <button type=button class="btn carousel-play" target="" > <span class="play-icon"></span> </button> <ol class="carousel-indicators"> <li data-target="#carousel-1429047459" data-slide-to="0" class="active"></li> <li data-target="#carousel-1429047459" data-slide-to="1" class=""></li> <li data-target="#carousel-1429047459" data-slide-to="2" class=""></li> </ol> <div class="carousel-inner"> <p><strong>Research Spotlights</strong></p> <div class="carousel-item active"> <span class="carousel-item-container"> <div class="card overlay-body" id="finding-new-options-for-sickle-cell-disease-pain"> <a href="/news/stories/new-options-sickle-cell-disease-pain" aria-label="Finding New Options for Sickle Cell Disease Pain"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/sickle-cell-landing-page.jpg?itok=K5u97IEp" width="900" height="507" alt="woman sitting in a chair looking at a laptop and wearing headphones" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/new-options-sickle-cell-disease-pain"> Finding New Options for Sickle Cell Disease Pain </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="electronic-health-record-systems-let-patients-choose-complementary-and-integrative-pain-treatments"> <a href="/news/stories/non-medication-pain-treatments-surgical-care" aria-label="Electronic Health Record Systems Let Patients Choose Complementary and Integrative Pain Treatments "> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/electronic-health-record.jpeg?itok=i9_a-TH2" width="900" height="507" alt="healthcare provider looking at electronic health records" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/non-medication-pain-treatments-surgical-care"> Electronic Health Record Systems Let Patients Choose Complementary and Integrative Pain Treatments </a> </p> </div> </div> </div> </div> </span> </div> <div class="carousel-item "> <span class="carousel-item-container"> <div class="card overlay-body" id="phone-based-pain-management-could-be-a-lifeline-for-low-income-patients"> <a href="/news/stories/phone-based-pain-management" aria-label="Phone-Based Pain Management Could be a Lifeline for Low-Income Patients"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/1187354794.jpg?itok=AES1ecYU" width="900" height="507" alt="Person stretching and grabbing their feet" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/phone-based-pain-management"> Phone-Based Pain Management Could be a Lifeline for Low-Income Patients </a> </p> </div> </div> </div> </div> </span> </div> <a class="carousel-control-prev" href="#carousel-1429047459" role="button" data-slide="prev"> <span class="carousel-control-prev-icon" aria-hidden="true"> <span class="angle-left-icon"></span> </span> <span class="sr-only">Previous</span> </a> <a class="carousel-control-next" href="#carousel-1429047459" role="button" data-slide="next"> <span class="carousel-control-next-icon" aria-hidden="true"> <span class="angle-right-icon"></span> </span> </span> <span class="sr-only">Next</span> </a> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview</h2> <h3>The Research Need</h3> <p>Recent decades have seen an overreliance on the prescription of opioids for chronic pain, which has contributed to an epidemic of opioid overdose deaths and addiction. Research has shown that non-opioid pain management interventions can be effective for treating acute and chronic pain.</p> <p>More support is needed to assess the impact of evidence-based health care strategies and clinical practices and procedures when they are included in health care systems. Pragmatic and implementation trials could identify strategies to most effectively implement evidence-based interventions and pain management guidelines.</p> <h3>About the Program</h3> <p>The Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) project will support multiple pragmatic trials to conduct research embedded in health care systems. These trials will determine the effectiveness of multiple non-opioid interventions for treating pain and assess the impact of implementing interventions or guidelines to improve pain management and reduce reliance on opioids.</p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-5830e86407a7225480520aefa5aa597e302bcb39f4fb029c700e9af8289620be"> <h2>Open Funding Opportunities </h2> There are no Open Funding Opportunities at this time. </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Program Details </h2> <div class="basic-content-grid-no-media"> <div> <p>To date, through the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup>, NIH has funded seven awards for this program, totaling $40.4 million.</p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Research Examples </h2> <div class="basic-content-grid-no-media"> <div> <p>Research institutions will undertake the following types of studies to determine the effectiveness of interventions for pain and assess the impact of implementing interventions to improve pain management within health care systems:</p> <ul> <li>Testing the use of decision support tools embedded in electronic health records to help patients and clinicians choose nondrug pain care after surgery and to improve patients’ role in managing their chronic pain</li> <li>Determining whether physical therapy (PT) plus transcutaneous electrical nerve stimulation in women with fibromyalgia is more effective than PT alone at community PT clinics</li> <li>Evaluating the effectiveness of incorporating a sustainable and billable mindfulness-based stress-reduction program into a primary care treatment for chronic low back pain</li> <li>Conducting a clinical trial in older adults (aged 65 years or older) with chronic low back pain to evaluate whether acupuncture is effective in this patient population</li> <li>Evaluating physical therapy telehealth interventions for low back pain in rural and low-income communities served by Federally Qualified Health Centers (FQHCs)</li> <li>Assessing the effectiveness of acupuncture and guided relaxation in patients with sickle cell disease</li> </ul> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-1468526609" class="col-12 accordion"> <div class="card-header col-12" id="heading-1468526609-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1468526609-0" aria-expanded="false" aria-controls="collapse-1468526609-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-1468526609-0" class="collapse " aria-labelledby="heading-1468526609-0" data-parent="#accordion-1468526609"> <div class="card-body"> <h3>Lead Trial Research Institutions</h3> <ul> <li><strong>Boston Medical Center</strong> – Massachusetts</li> <li><strong>Kaiser Foundation Research Institute</strong> – California</li> <li><strong>Mayo Clinic</strong> – Minnesota</li> <li><strong>University of Illinois at Chicago</strong> – Illinois </li> <li><strong>University of Iowa</strong> – Iowa</li> <li><strong>University of Utah</strong> - Utah </li> </ul> <h3>Resource Coordinating Center</h3> <ul> <li><strong>Duke University</strong> – North Carolina</li> </ul> </div> </div> </div> <div id="accordion-1931323191" class="col-12 accordion"> <div class="card-header col-12" id="heading-1931323191-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1931323191-1" aria-expanded="false" aria-controls="collapse-1931323191-1"> Funded Projects </button> </h2> </div> <div id="collapse-1931323191-1" class="collapse " aria-labelledby="heading-1931323191-1" data-parent="#accordion-1931323191"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-878ad03236ca65d58c0c504adf759598625814c088169500714554001ce4a85d"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2024 </div> <div class="col-lg-6 col-md-12"> Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=171#project-title-46441> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=171#project-title-46441">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 27, 2024 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2021 </div> <div class="col-lg-6 col-md-12"> Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=171#project-title-39826> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=171#project-title-39826">Summary</a> </div> <div class="col-6 d-lg-none"> Sep 25, 2021 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Nonpharmacologic Pain Management in FQHC primary care clinics </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=171#project-title-38291> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=171#project-title-38291">Summary</a> </div> <div class="col-6 d-lg-none"> Sep 29, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=171#project-title-38296> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=171#project-title-38296">Summary</a> </div> <div class="col-6 d-lg-none"> Sep 29, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Non-pharmacological Options in postoperative Hospital-based And Rehabilitation pain Management (NOHARM) pragmatic clinical trial </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" target="" href=/funding/awarded?research_program=171#project-title-34091> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=171#project-title-34091">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" target="" href=/funding/awarded?research_program=171> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contacts </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#4c3b292e293e3b260c212d252062222524622b233a">Wendy Weber, N.D., Ph.D., M.P.H.</a><br /> NCCIH</p> <p><a href="/cdn-cgi/l/email-protection#f4869b969d9ada969b9d9a919581b49a9d9cda939b82">Robin Boineau, M.D., M.A.</a><br /> NCCIH</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Participating NIH Institutes, Centers, and Offices</h3> <p><ul> <li><a href="https://nccih.nih.gov/">National Center for Complementary and Integrative Health (NCCIH)</a></li> <li><a href="https://www.nia.nih.gov/">National Institute on Aging (NIA)</a></li> <li><a href="http://www.niams.nih.gov/">National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)</a></li> <li><a href="https://www.nichd.nih.gov/"><em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development (NICHD)</a> <ul> <li><a href="https://www.nichd.nih.gov/about/org/ncmrr">National Center for Medical Rehabilitation Research (NCMRR)</a></li> </ul> </li> <li><a href="http://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li> <li><a href="http://www.ninr.nih.gov/">National Institute of Nursing Research (NINR)</a></li> <li><a href="http://obssr.od.nih.gov/">Office of Behavioral and Social Sciences Research (OBSSR)</a></li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul> <li><a href="https://heal.nih.gov/research/clinical-research/health-equity-pain-management">Advancing Health Equity in Pain Management</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/back-pain">Back Pain Consortium Research Program (BACPAC)</a></li> <li><a href="https://heal.nih.gov/research/preclinical-translational/biomarkers">Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/eppic-net">Early Phase Pain Investigation Clinical Network (EPPIC Net)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/hemodialysis">Integrated Approach to Pain and Opioid Use in Hemodialysis Patients (HOPE)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/integrative-management-chronic-pain">Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/pain-management-research">Pain Management Effectiveness Research Network (ERN)</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated August 20, 2024</p> </div> </div> </div> <footer 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Pragmatic Studies for Pain Management Without Opioids | NIH HEAL Initiative