Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders

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Options For Opioid Use Disorder and Overdose</a></li> <li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders</li> </ol> </nav> </div> </div> <div class="col-sm-12 col-md-5"> </div> </div> </div> <div class="layout-content"> <div> <div id="block-particle-content"> <h1> Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders </h1> <div> <div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> </div> <p class='col-12'> <h2>Overview</h2> <h3>The Research Need</h3> <p>Buprenorphine to treat opioid use disorder is typically taken by mouth daily, over long periods of time. Buprenorphine is formulated as a tablet or film that is placed under the tongue or between the gums and cheeks so it can dissolve slowly. The U.S. Food and Drug Administration recently reported that oral buprenorphine can cause dental caries, dental abscesses or infections, tooth erosion, and tooth loss. Research is needed to address these harmful side effects of buprenorphine.</p> <h3>About the Program</h3> <p>This program supports basic research to understand how buprenorphine causes oral complications. Research explores changes in the mouth that result from buprenorphine administration and their effects on oral bacteria, saliva composition, pH, and other factors that may affect the integrity and physiology of teeth.</p> <p>The program also supports clinical research to determine clinical progression and outcomes of oral disease in people taking medications for opioid use disorder. Research includes both newly developed oral complications and worsening of existing oral problems. Research also studies behavioral and psychosocial factors that influence oral health in people who take buprenorphine by mouth, the role of access to and quality of dental care for these individuals, and prevention strategies.</p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-1c4a3e4c705d300b3eed364a2a5b25eb99c167d41adc418ecf602e283acd1ed0"> <h2>Open Funding Opportunities </h2> There are no Open Funding Opportunities at this time. </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Research Examples </h2> <div class="basic-content-grid-no-media"> <div> <p>Research examples supported by this program include: </p> <ul> <li>Determining direct chemical effects of buprenorphine or other components of this medication on teeth and oral tissues</li> <li>Identifying the effects of buprenorphine and other medications for opioid use disorder on the oral microbiome</li> <li>Conducting clinical studies to determine the onset, extent, and rate of progression of oral complications in individuals taking buprenorphine</li> <li>Identifying barriers to and facilitators of oral health care in people with opioid use disorder</li> <li>Developing and evaluating strategies to prevent dental and oral disease in individuals receiving medications for opioid use disorder</li> </ul> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-504462390" class="col-12 accordion"> <div class="card-header col-12" id="heading-504462390-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-504462390-0" aria-expanded="false" aria-controls="collapse-504462390-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-504462390-0" class="collapse " aria-labelledby="heading-504462390-0" data-parent="#accordion-504462390"> <div class="card-body"> <ul> <li><strong>Brigham and Women's Hospital</strong> – Massachusetts</li> <li><strong>University of Houston</strong> – Texas</li> <li><strong>University of Kentucky </strong>– Kentucky</li> <li><strong>University of Pittsburgh</strong> – Pennsylvania</li> </ul> </div> </div> </div> <div id="accordion-522191697" class="col-12 accordion"> <div class="card-header col-12" id="heading-522191697-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-522191697-1" aria-expanded="false" aria-controls="collapse-522191697-1"> Funded Projects </button> </h2> </div> <div id="collapse-522191697-1" class="collapse " aria-labelledby="heading-522191697-1" data-parent="#accordion-522191697"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-81d34fb0f79340c15d4aae2c29a77a694a295b96df94dd821b89a07a4859d30b"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> Understanding the Association Between Sublingual Buprenorphine and Oral Health Outcomes </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=44106#project-title-46246> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=44106#project-title-46246">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 28, 2023 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> Comparative Risk of Oral Complications Associated with Medications for Opioid Use Disorder: A Mixed-Methods Approach </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=44106#project-title-46261> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=44106#project-title-46261">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 28, 2023 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> Oral Complications From Sublingual Buprenorphine Treatment: A Prospective Cohort Study </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=44106#project-title-46251> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=44106#project-title-46251">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 28, 2023 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2023 </div> <div class="col-lg-6 col-md-12"> Elucidating High Oral Fluid Exposure Mechanisms of Buprenorphine to Reduce Dental Caries </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=44106#project-title-46256> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=44106#project-title-46256">Summary</a> </div> <div class="col-6 d-lg-none"> Nov 28, 2023 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" href=/funding/awarded?research_program=44106> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contact </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#c9adaca7a8e7afa0baaaa1acbb89a7a0a1e7aea6bf">Dena Fischer, D.D.S., M.S.D., M.S.</a>, NIDCR</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Participating NIH Institutes, Centers, and Offices</h3> <p><ul> <li><a href="https://nccih.nih.gov/">National Center for Complementary and Integrative Health (NCCIH)</a> </li> <li><a href="https://www.nidcr.nih.gov/">National Institute of Dental and Craniofacial Research (NIDCR)</a></li> <li><a href="https://nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul> <li><a href="/research/medication-options/focusing-development">Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose</a></li> <li><a href="/research/medication-options/immunotherapies">Development of Novel Immunotherapeutics for Opioid Addiction</a></li> <li><a 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