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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316574/High_performance_liquid_chromatography_method_for_the_pharmacokinetic_study_of_bicalutamide_SMEDDS_and_suspension_formulations_after_oral_administration_to_rats"><img alt="Research paper thumbnail of High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats" class="work-thumbnail" src="https://attachments.academia-assets.com/44327386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316574/High_performance_liquid_chromatography_method_for_the_pharmacokinetic_study_of_bicalutamide_SMEDDS_and_suspension_formulations_after_oral_administration_to_rats">High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats</a></div><div class="wp-workCard_item"><span>Talanta</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating prostate cancer. To evaluate the bioavailability of bicalutamide from bicalutamide self-microemulsifying drug delivery systems (SMEDDS) and bicalutamide suspension formulations, a sensitive, specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of bicalutamide (BCT) in rat blood plasma. Letrozole (LZ) was used as the internal standard. The chromatographic separation was achieved on C18 column at 35 degrees C, with a mobile phase consisting of water: acetonitrile (adjusted to pH 3.0 with 20% o-phosphoric acid) (60:40), at a flow rate of 1.0 mL min(-1). Bicalutamide and letrozole were well separated with retention times of 10.9+/-0.2 and 5.7+/-0.2 min, respectively. The method was successfully used to determine pharmacokinetics of bicalutamide, following oral administration of bicalutamide susp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdb72f3223267354870daaa9186389f0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327386,"asset_id":14316574,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327386/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316574"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316574"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316574; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells"><img alt="Research paper thumbnail of The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells">The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O-2/graphite cells with 1M LiPF6 EC:EMC ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O-2/graphite cells with 1M LiPF6 EC:EMC electrolyte containing either 0, 1 or 2 wt.% vinylene carbonate were studied using the High Precision Charger at Dalhousie University, automated cell storage and AC impedance. Vinylene carbonate (VC) was found to improve the coulombic efficiency of the cells, decrease charge endpoint capacity slippage and decrease self discharge, in all cases primarily by slowing electrolyte oxidation at the positive electrode. The beneficial impacts of VC are greater in LiCoO2 cells than in Li[Ni0.42Mn0.42Co0.16]O-2 cells. One percent VC is enough to derive the benefits without causing an impedance rise in the cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316573]").text(description); $(".js-view-count[data-work-id=14316573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316573,"title":"The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells","internal_url":"https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316572"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system"><img alt="Research paper thumbnail of A class of discontinuous dynamical systems IV. A laboratory air–water system" class="work-thumbnail" src="https://attachments.academia-assets.com/44327381/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system">A class of discontinuous dynamical systems IV. A laboratory air–water system</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An air-water experimental system consisting of two inlets and one outlet is constructed and chara...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An air-water experimental system consisting of two inlets and one outlet is constructed and characterised. It reaches the state of sliding mode, or equivalently, two phase slug ow. The linear hydraulic model proposed in the literature is adequate to describe it. Experimental data are used to tune this model. The resistance to the ow of air through the outlet valve during the two phase ow is much larger than that when air alone ows out. At the operating range, the resistance to water ow is not a ected by the presence of air. ?</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="955b86cbfefa3da6fcccd4bd1abee47d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327381,"asset_id":14316572,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327381/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316572"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316572"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316572; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316572]").text(description); $(".js-view-count[data-work-id=14316572]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316572; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316572']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "955b86cbfefa3da6fcccd4bd1abee47d" } } $('.js-work-strip[data-work-id=14316572]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316572,"title":"A class of discontinuous dynamical systems IV. A laboratory air–water system","internal_url":"https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327381,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327381/thumbnails/1.jpg","file_name":"A_class_of_discontinuous_dynamical_syste20160402-27181-24hj46.pdf","download_url":"https://www.academia.edu/attachments/44327381/download_file","bulk_download_file_name":"A_class_of_discontinuous_dynamical_syste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327381/A_class_of_discontinuous_dynamical_syste20160402-27181-24hj46-libre.pdf?1459606228=\u0026response-content-disposition=attachment%3B+filename%3DA_class_of_discontinuous_dynamical_syste.pdf\u0026Expires=1739812843\u0026Signature=HwxqJEJfcXyoTn7dNPw2swCLODq-bhWtodXguuTbLQmUnNkKEtoUIQGUfrNal1WwA2kvMmQN2XPcz080v4oGSXorzSy8HQr2pwgHvT13ouHacAlALPGXJ0sQft10dn8JqmoaDGLdn4auSUWKltrDIGJdr4Z-Qc2q1L5MbdbjmB46XLUhnkbSjdjGCaF~uIBFiur8qhw1D-ep~DYHnupKnp~-oFPmHjjvXjYjYYq~Hx7uCZHqdtJJvXYy0Zri-JtD6aTMYoCQuCoLkL5VTSXYL5v63V8926ebRZ7PGyk~3vLtbG7-VpbEEUfLNpZ2NHxabhW8s6QRF-E~MOg0bMge1w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316571"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus"><img alt="Research paper thumbnail of Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus" class="work-thumbnail" src="https://attachments.academia-assets.com/44327392/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus">Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus</a></div><div class="wp-workCard_item"><span>BMC neurology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intracranial haemorrhage accounts for 30-60 % of all stroke admissions into a hospital, with hype...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intracranial haemorrhage accounts for 30-60 % of all stroke admissions into a hospital, with hypertension being the main risk factor. Presence of intraventricular haematoma is considered a poor prognostic factor due to the resultant obstruction to CSF and the mass effect following the presence of blood resulting in raised intracranial pressure and hydrocephalus. We report the results following endoscopic decompression of obstructive hydrocephalus and evacuation of haematoma in patients with hypertensive intraventricular haemorrhage. During a two year period, 25 patients diagnosed as having an intraventricular haemorrhage with obstructive hydrocephalus secondary to hypertension were included in this study. All patients underwent endoscopic evacuation of the haematoma under general anaesthesia. Post operative evaluation was done by CT scan and Glasgow outcome scale. Of the 25 patients, thalamic haemorrhage was observed in 12 (48%) patients, while, 11 (44%) had a putaminal haematoma. N...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="97467220a7aefd9c22fe6a2c643e9c55" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327392,"asset_id":14316571,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327392/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316571"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316571; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316571]").text(description); $(".js-view-count[data-work-id=14316571]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316571; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316571']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "97467220a7aefd9c22fe6a2c643e9c55" } } $('.js-work-strip[data-work-id=14316571]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316571,"title":"Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus","internal_url":"https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327392/thumbnails/1.jpg","file_name":"Endoscopic_management_of_hypertensive_in20160402-32742-15hpcd7.pdf","download_url":"https://www.academia.edu/attachments/44327392/download_file","bulk_download_file_name":"Endoscopic_management_of_hypertensive_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327392/Endoscopic_management_of_hypertensive_in20160402-32742-15hpcd7-libre.pdf?1459606228=\u0026response-content-disposition=attachment%3B+filename%3DEndoscopic_management_of_hypertensive_in.pdf\u0026Expires=1739812843\u0026Signature=TDy21iJwUt1KP65xZo7c~7BQUzjvKdj3Dp32XmEZ07cOkQ8zR8SM-wW0i-mvBiLws0xtyjukAVxdko6fNVSunh2p~o9teKQnzMpXPAwUDQToD-PZaHSlENaHgYfiMsEutmffg7QcrsEvSUzdxDyAuY~B5tcRrJfL37fFGxMdjO6c5RzBJBNddKBx341qOEREASSYHnsqADBi47lIymg237aL~oNlXQ7KMKNESBO3jHohSbQTmRSIEMgqynpWNE6qvMjgP9WlUzTcgjM2nyXk7YBiaSsS9~nyJ48A6dsySGwL1qhUFqZlnUGyhD~tMtFSYof0SYQwBkOAXr-WTO2v2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316570/Mucinous_cystadenoma_A_rare_entity"><img alt="Research paper thumbnail of Mucinous cystadenoma: A rare entity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316570/Mucinous_cystadenoma_A_rare_entity">Mucinous cystadenoma: A rare entity</a></div><div class="wp-workCard_item"><span>Dental research journal</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cystadenoma is a rare benign salivary gland tumor that chiefly originates in the minor salivary g...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cystadenoma is a rare benign salivary gland tumor that chiefly originates in the minor salivary glands as a cystic growth with papillary projections into the cystic lumen without the lymphoid element. It is further classified into two histopathological variants that have been recognized by World Health Organization as the papillary and the mucinous forms of cystadenoma. Clinically, it is difficult to differentiate from other benign minor salivary tumors and mucous retention phenomenon. Diagnosis is chiefly based on characteristics histological features. It is believed that the salivary gland tumors are difficult to diagnose and interpret because there are varied patterns of presentation. The study of salivary gland disorders has increased in leaps and bounds. The authors report a case of mucinous cystadenoma of the minor salivary gland on the hard palate, which is even rarest of the rarely reported cystadenomas of the minor salivary glands.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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The optimized nanodispersions were prepared by double emulsification solvent evaporation method using high pressure homogenizer (500 bar pressure, 2 cycles) to homogenize primary emulsion. Particle size of nanodispersion was found to be dependent on PLGA concentration, PLGA:drug ratio, PVA concentration and W:O phase volume ratio whereas drug encapsulation was related to PLGA concentration and PLGA:drug ratio. Encapsulation efficiency of optimized nanodispersion was 62.5% with a mean particle size of around 118.5 nm which makes them a suitable candidate for ocular administration. Drug release kinetic studies indicate a sustained release profile of moxifloxacin from nanodispersions. In addition, in vitro and in vivo studies have revealed that PLGA nanodispersions were non irritant, prevent ocular drainage of moxifloxacin with enhanced ocular bioavailability by 3-fold.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316569; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="14316568"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316568/Comparative_Evaluation_of_Local_Anaesthesia_with_Adrenaline_and_Without_Adrenaline_on_Blood_Glucose_Concentration_in_Patients_Undergoing_Tooth_Extractions"><img alt="Research paper thumbnail of Comparative Evaluation of Local Anaesthesia with Adrenaline and Without Adrenaline on Blood Glucose Concentration in Patients Undergoing Tooth Extractions" class="work-thumbnail" src="https://attachments.academia-assets.com/44327408/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316568/Comparative_Evaluation_of_Local_Anaesthesia_with_Adrenaline_and_Without_Adrenaline_on_Blood_Glucose_Concentration_in_Patients_Undergoing_Tooth_Extractions">Comparative Evaluation of Local Anaesthesia with Adrenaline and Without Adrenaline on Blood Glucose Concentration in Patients Undergoing Tooth Extractions</a></div><div class="wp-workCard_item"><span>Journal of Maxillofacial and Oral Surgery</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Lignocaine hydrochloride is the most widely used and easily available local anaestheti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Lignocaine hydrochloride is the most widely used and easily available local anaesthetic agent. Adrenaline is frequently combined with lignocaine to enhance the duration of anaesthesia, decrease toxicity, to achieve vasoconstriction and to provide a bloodless field. Aim and Objective This study was conducted to do the comparative evaluation of local anaesthesia with adrenaline and without adrenaline on blood glucose concentration in patients under going tooth extraction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae325414feda2992c8c5736d8e96341c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327408,"asset_id":14316568,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327408/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316568"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316568"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316568; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316567"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316567/AQUEOUS_PHASE_TRANSFER_OF_OLEIC_ACID_COATED_IRON_OXIDE_NANOPARTICLES_INFLUENCE_OF_SOLVENTS_AND_SURFACTANTS_ON_STABILITY_AND_PHARMACEUTICAL_APPLICATIONS_OF_FERROFLUID"><img alt="Research paper thumbnail of AQUEOUS PHASE TRANSFER OF OLEIC ACID COATED IRON OXIDE NANOPARTICLES: INFLUENCE OF SOLVENTS AND SURFACTANTS ON STABILITY AND PHARMACEUTICAL APPLICATIONS OF FERROFLUID" class="work-thumbnail" src="https://attachments.academia-assets.com/39136906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316567/AQUEOUS_PHASE_TRANSFER_OF_OLEIC_ACID_COATED_IRON_OXIDE_NANOPARTICLES_INFLUENCE_OF_SOLVENTS_AND_SURFACTANTS_ON_STABILITY_AND_PHARMACEUTICAL_APPLICATIONS_OF_FERROFLUID">AQUEOUS PHASE TRANSFER OF OLEIC ACID COATED IRON OXIDE NANOPARTICLES: INFLUENCE OF SOLVENTS AND SURFACTANTS ON STABILITY AND PHARMACEUTICAL APPLICATIONS OF FERROFLUID</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/NiluJain">Nilu Jain</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SohailAkhter1">Sohail Akhter</a></span></div><div class="wp-workCard_item"><span>Magnetohydrodynamics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this work, iron oxide nanoparticles were prepared by a classical co-precipitation method in an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this work, iron oxide nanoparticles were prepared by a classical co-precipitation method in an inert atmosphere. In the first step, iron oxide nanoparticles were synthesized, coated with oleic acid (5-50%) and its dispersions in different organic solvents (n-hexane, n-heptane and n-octane) were prepared. In the second step, a ferrofluid was obtained by a mini-emulsion process with the aid of different surfactants: sodium dodecyl sulphate (SDS), polysorbate 20 (tween 20), sorbitan monolaurate (span 20), poloxamer 188, poloxamer 407, Polyoxyl 23 lauryl ether (brij 35), Polyoxyl 40 stearate (myrj 52), vitamin E polyethylene glycol succinate (vitamin E TPGS) and docusate sodium. Characterization of oleic acid coated iron oxide nanoparticles were done by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray powder diffraction (XRD). Stability study of the aqueous ferrofluid was performed by measuring the particle size and polydispersity index within a storage period of six months. Clinical application of ferrofluid in targeted drug delivery systems was also discussed with respect to different surfactants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="723ba75ca450cf5cad38ad92ea3bbcda" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39136906,"asset_id":14316567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39136906/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316567; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery"><img alt="Research paper thumbnail of UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery">UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://iabfu.academia.edu/NiyazAhmad">Niyaz Ahmad</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A simple, sensitive and selective ultra performance liquid chromatographic (UPLC) method with qua...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A simple, sensitive and selective ultra performance liquid chromatographic (UPLC) method with quadrapole-time of flight-mass spectrometric (Q-TOF-MS/MS) detection was developed for the determination of moxifloxacin (moxi) in rabbit aqueous humor. After a simple protein-precipitation by acetonitrile, the post-treatment samples were separated on a UPLC Bridged Ethyl Hybrid (BEH) C-18 column with 0.1% formic acid in water as a mobile phase</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316566]").text(description); $(".js-view-count[data-work-id=14316566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316566,"title":"UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery","internal_url":"https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316565"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report"><img alt="Research paper thumbnail of Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report" class="work-thumbnail" src="https://attachments.academia-assets.com/44327389/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report">Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report</a></div><div class="wp-workCard_item"><span>Journal of Maxillofacial and Oral Surgery</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment and reconstruction of oral scar contracture, is always a challenging procedure to resto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment and reconstruction of oral scar contracture, is always a challenging procedure to restore structure and functions of the oral cavity. We present a case of a patient with limited mouth opening who sustained extensive oral scar contracture with complete adhesion of tongue to floor of mouth following ingestion of caustic soda without his knowledge 4 years back. We performed a surgical release of the scar contractures from buccal mucosa on both sides, along with a release of the tongue from the floor of the mouth, followed by reconstruction of all sites using split skin grafts. Adequate mouth opening and tongue movement was achieved. There was a follow up period of 1 month with excellent mouth opening and tongue function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="784967ef802ce3fd1d7ae479d54ef940" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327389,"asset_id":14316565,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327389/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316565"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316565"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316565; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "784967ef802ce3fd1d7ae479d54ef940" } } $('.js-work-strip[data-work-id=14316565]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316565,"title":"Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report","internal_url":"https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327389,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327389/thumbnails/1.jpg","file_name":"Unusual_presentation_of_caustic_ingestio20160402-30507-vv91iv.pdf","download_url":"https://www.academia.edu/attachments/44327389/download_file","bulk_download_file_name":"Unusual_Presentation_of_Caustic_Ingestio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327389/Unusual_presentation_of_caustic_ingestio20160402-30507-vv91iv-libre.pdf?1459606227=\u0026response-content-disposition=attachment%3B+filename%3DUnusual_Presentation_of_Caustic_Ingestio.pdf\u0026Expires=1739812843\u0026Signature=Af-I3~e3KR-32gzCD0gBpf2ohTSLQGquYVTVSUN751QNp3V-A5nZVqrYAgyDh5lataCO0OQzeooHweGVRXAXd7ZJBZlsP5TG7CW8MNSgQ7GutBg~H8~2kF~xP7ITIOnWjs2kVK0O~Du2EOs7gaOouxzt5p45LgAiVDmUK5Vh32c-dTWgWz9l~Knj2-04v5EIhKJThE0cC5OcqKzhPESUECyH1rTV5gtcKC75NolYS5X0DqJ4oOGaBcjBPTzjwtWif93TrsclaFtQ7OeYt-xxH2lyFBGwMDQvLlm2XBlc5GSEs3asaX3Qd7HftxL81k-RvTb84h9HowI2tsu3tfOVTA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316564"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316564/Evaluation_of_efficacy_of_arthrocentesis_with_normal_saline_with_or_without_sodium_hyaluronate_in_treatment_of_internal_derangement_of_TMJ_A_prospective_randomized_study_in_20_patients"><img alt="Research paper thumbnail of Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ – A prospective randomized study in 20 patients" class="work-thumbnail" src="https://attachments.academia-assets.com/44327415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316564/Evaluation_of_efficacy_of_arthrocentesis_with_normal_saline_with_or_without_sodium_hyaluronate_in_treatment_of_internal_derangement_of_TMJ_A_prospective_randomized_study_in_20_patients">Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ – A prospective randomized study in 20 patients</a></div><div class="wp-workCard_item"><span>Journal of Oral Biology and Craniofacial Research</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arthrocentesis Sodium hyaluronidase a b s t r a c t Purpose: To compare the outcome of arthrocent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arthrocentesis Sodium hyaluronidase a b s t r a c t Purpose: To compare the outcome of arthrocentesis alone and arthrocentesis with sodium hyaluronate in internal derangement of TMJ. Materials and methods: 20 patients of disc displacement with reduction of TMJ were randomized into 2 experimental groups. Control group of patients received arthrocentesis alone and study group of patients received arthrocentesis with sodium hyaluronate. Patients TMJ status and clinical symptoms were evaluated for 6 months follow up. The clinical parameter recorded were maximal mouth opening (MMO), lateral excursions (right and left side), protrusive movement, joint noises, and pain (at rest, at function).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="161607b8935c2d05b14cb1d7f73fb929" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327415,"asset_id":14316564,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316564"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316564"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316564; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316563/Bone_metastases_as_the_initial_presentation_of_carcinoma_of_gall_bladder_a_rarity"><img alt="Research paper thumbnail of Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity" class="work-thumbnail" src="https://attachments.academia-assets.com/44327419/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316563/Bone_metastases_as_the_initial_presentation_of_carcinoma_of_gall_bladder_a_rarity">Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity</a></div><div class="wp-workCard_item"><span>Indian Journal of Surgery</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Distant metastases are rare form of presentation of carcinoma gall bladder. Bony pain as initial ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Distant metastases are rare form of presentation of carcinoma gall bladder. Bony pain as initial presentation is quite unusual. A 50-year-old woman presented with the pain in right shoulder. Investigation showed metastatic adenocarcinoma in the head of humerus and the primary was found in the gall bladder. She received local radiotherapy for bone metastases and undergoing systemic chemotherapy. Carcinoma gall bladder is a common abdominal malignancy, mostly presenting in advanced stage with abdominal symptoms and obstructive jaundice. In presence of metastasis, the management is palliative and role of chemotherapy is limited for palliation symptoms.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c43f324e0010a1482f04a6f2247018a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327419,"asset_id":14316563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327419/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316563; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits"><img alt="Research paper thumbnail of Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits">Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a></span></div><div class="wp-workCard_item"><span>Colloids and Surfaces B: Biointerfaces</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Poor drug penetration and rapid clearance after topical instillation of a drug formulation into t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops. Along with this, poor encapsulation efficiency of hydrophilic drug in polymeric nanoparticles remains a major formulation challenge. Taking this perspective into consideration, dorzolamide (DZ)-loaded PLGA nanoparticles were developed employing two different emulsifiers (PVA and vitamin E TPGS) and the effects of various formulation and process variables on particle size and encapsulation efficiency were assessed. Nanoparticles emulsified with vitamin E TPGS (DZ-T-NPs) were found to possess enhanced drug encapsulation (59.8±6.1%) as compared to those developed with PVA as emulsifier (DZ-P-NPs). Transcorneal permeation study revealed a significant enhancement in permeation (1.8-2.5 fold) as compared to solution. In addition, ex vivo biodistribution study showed a higher concentration of drug in the aqueous humour (1.5-2.3 fold). Histological and IR-camera studies proved the non-irritant potential of the formulations. Pharmacoscintigraphic studies revealed the reduced corneal clearance, as well as naso-lachrymal drainage in comparison to drug solution. Furthermore, efficacy study revealed that DZ-P-NPs and DZ-T-NPs significantly reduced the intraocular pressure by 22.81% and 29.12%, respectively, after a single topical instillation into the eye.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316562,"title":"Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits","internal_url":"https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316561/A_review_on_the_strategies_for_oral_delivery_of_proteins_and_peptides_and_their_clinical_perspectives"><img alt="Research paper thumbnail of A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/44327429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316561/A_review_on_the_strategies_for_oral_delivery_of_proteins_and_peptides_and_their_clinical_perspectives">A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a></span></div><div class="wp-workCard_item"><span>Saudi Pharmaceutical Journal</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones are being developed utilizing different sophisticated biotechnological techniques like recombinant DNA technology and protein purification. However, the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. These problems can be overcome by adopting techniques such as chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides, several research endeavors have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes such as oral, transdermal, vaginal, rectal, pulmonary and intrauterine. This review article emphasizes on the recent advancements made in the delivery of protein and peptides by a non-invasive (peroral) route into the body.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="80629653f68bd649c3bc1b3a5b130aa4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327429,"asset_id":14316561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327429/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316561; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316560"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316560/An_encyclopedia_of_mouse_DNA_elements_Mouse_ENCODE_"><img alt="Research paper thumbnail of An encyclopedia of mouse DNA elements (Mouse ENCODE)" class="work-thumbnail" src="https://attachments.academia-assets.com/44327396/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316560/An_encyclopedia_of_mouse_DNA_elements_Mouse_ENCODE_">An encyclopedia of mouse DNA elements (Mouse ENCODE)</a></div><div class="wp-workCard_item"><span>Genome Biology</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="07268a8146c95a8967f9705896b2bf0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327396,"asset_id":14316560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327396/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316560; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316560]").text(description); $(".js-view-count[data-work-id=14316560]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316560; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316560']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316559/Dental_Therapeutic_Systems"><img alt="Research paper thumbnail of Dental Therapeutic Systems" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316559/Dental_Therapeutic_Systems">Dental Therapeutic Systems</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/NiluJain">Nilu Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://omc.academia.edu/AlkaAhuja">Alka Ahuja</a></span></div><div class="wp-workCard_item"><span>Recent Patents on Drug Delivery & Formulation</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The recognition of periodontal diseases as amenable to local antibiotherapy has resulted in a par...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The recognition of periodontal diseases as amenable to local antibiotherapy has resulted in a paradigmatic shift in treatment modalities of dental afflictions. Moreover the presence of antimicrobial resistance, surfacing of untoward reactions owing to systemic consumption of antibiotics has further advocated the use of local delivery of physiologically active substances into the periodontal pocket. While antimicrobials polymerized into acrylic strips, incorporated into biodegradable collagen and hollow permeable cellulose acetate fibers, multiparticulate systems, bio-absorbable dental materials, biodegradable gels/ointments, injectables, mucoadhesive microcapsules and nanospheres will be more amenable for direct placement into the periodontal pockets the lozenges, buccoadhesive tablets, discs or gels could be effectively used to mitigate the overall gingival inflammation. Whilst effecting controlled local delivery of a few milligram of an antibacterial agent within the gingival crevicular fluid for a longer period of time, maintaining therapeutic concentrations such delivery devices will circumvent all adverse effects to non- oral sites. Since the pioneering efforts of Goodson and Lindhe in 1989, delivery at gingival and subgingival sites has witnessed a considerable progress. The interest in locally active systems is evident from the patents being filed and granted. The present article shall dwell in reviewing the recent approaches being proffered in the field. Patents as by Shefer, et al. US patent, 6589562 dealing with multicomponent biodegradable bioadhesive controlled release system for oral care products, Lee, et al. 2001, US patent 6193994, encompassing a locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof and method of treating periodontal disease as suggested by Basara in 2004via US patent 6830757, shall be the types of intellectual property reviewed and presented in the current manuscript.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316559]").text(description); $(".js-view-count[data-work-id=14316559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316559,"title":"Dental Therapeutic Systems","internal_url":"https://www.academia.edu/14316559/Dental_Therapeutic_Systems","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316558/CNS_Drug_Delivery_Systems_Novel_Approaches"><img alt="Research paper thumbnail of CNS Drug Delivery Systems: Novel Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/44327400/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316558/CNS_Drug_Delivery_Systems_Novel_Approaches">CNS Drug Delivery Systems: Novel Approaches</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/DivyaVohra">Divya Vohora</a></span></div><div class="wp-workCard_item"><span>Recent Patents on Drug Delivery & Formulation</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielde...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielded against potentially toxic substances by the presence of two barrier systems: the blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Despite aggressive research, patients suffering from fatal and/or debilitating central nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, far outnumber those dying of all types of systemic cancers or heart diseases. The abysmally low number of potential therapeutics reaching commercial success is primarily due to the complexity of the CNS drug development. The clinical failure of many probable candidates is often, ascribable to poor delivery methods which do not pervade the unyielding BBB. It restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in the pharmacological treatment of central nervous system (CNS) disorders. General methods that can enhance drug delivery to the brain are, therefore, of great pharmaceutical interest. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, prodrugs, chemical drug delivery, carrier-mediated drug delivery, receptor/vector mediated drug delivery and intranasal drug delivery, which exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain, are widely used. On the other hand the invasive methods which primarily rely on disruption of the BBB integrity by osmotic or biochemical means, or direct intracranial drug delivery by intracerebroventricular, intracerebral or intrathecal administration after creating reversible openings in the head, are recognised. Extensive review pertaining specifically, to the patents relating to drug delivery across the CNS is currently available. However, many patents e.g. US63722506, US2002183683 etc., have been mentioned in a few articles. It is the objective of this article to expansively review drug delivery systems for CNS by discussing the recent patents available.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a8ede30271f567fa403562e7d8ebb58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327400,"asset_id":14316558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327400/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316558; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases"><img alt="Research paper thumbnail of Argemone mexicana poisoning: autopsy findings of two cases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases">Argemone mexicana poisoning: autopsy findings of two cases</a></div><div class="wp-workCard_item"><span>Forensic Science International</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemic dropsy, a disease due to Argemone mexicana poisoning, is characterized by pathological a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemic dropsy, a disease due to Argemone mexicana poisoning, is characterized by pathological accumulation of diluted lymph in body tissues and cavities. Recently, the largest epidemic of the disease in India affected Delhi and its neighboring states during the months of August–September 1998. Over 3000 persons fell ill, and more than 65 died in the state of Delhi alone. Two</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316557"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316557"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316557; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316557]").text(description); $(".js-view-count[data-work-id=14316557]").attr('title', description).tooltip(); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316557]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316557,"title":"Argemone mexicana poisoning: autopsy findings of two cases","internal_url":"https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS"><img alt="Research paper thumbnail of ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS">ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a></span></div><div class="wp-workCard_item"><span>Journal of Liquid Chromatography & Related Technologies</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate the bioavailability of exemestane (EXM) from self-microemulsifying drug delivery syst...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate the bioavailability of exemestane (EXM) from self-microemulsifying drug delivery systems (SMEDDS) and suspension formulations, a sensitive, specific and rapid liquid chromatography–mass spectrometric method was developed and validated. The analyte was extracted from plasma samples and detected by mass spectrometry with an atmospheric pressure positive-ion chemical ionization (APCI) mode using a heated nebulizer interface. Progesterone (PGS) was used as</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316556]").text(description); $(".js-view-count[data-work-id=14316556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316556]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316556,"title":"ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS","internal_url":"https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316555/The_impact_of_nutritional_status_on_the_outcome_of_Indian_patients_undergoing_neurosurgical_shunt_surgery"><img alt="Research paper thumbnail of The impact of nutritional status on the outcome of Indian patients undergoing neurosurgical shunt surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/44327404/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316555/The_impact_of_nutritional_status_on_the_outcome_of_Indian_patients_undergoing_neurosurgical_shunt_surgery">The impact of nutritional status on the outcome of Indian patients undergoing neurosurgical shunt surgery</a></div><div class="wp-workCard_item"><span>British Journal of Nutrition</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Undernutrition is common in surgical patients, is frequently unrecognised and is strongly associa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Undernutrition is common in surgical patients, is frequently unrecognised and is strongly associated with adverse outcomes such as high rates of complications and mortality, worsening functional status and prolonged hospitalisation. Owing to the associated infection and symptoms such as repeated vomiting, a high prevalence of undernutrition is expected in hydrocephalus patients, which may contribute to their poor surgical outcomes. The aim of this study was to evaluate the influence of preoperative nutritional status on the outcome of Indian patients with hydrocephalus undergoing neurosurgical shunt surgery. One hundred and twenty-four consecutive patients undergoing scheduled hydrocephalus shunt surgery were studied prospectively. All patients underwent nutritional screening according to different parameters prior to surgery. The patients were classified into normally nourished and undernourished groups. The undernourished group was further subdivided into moderately and severely undernourished. The surgical outcome was compared between these groups. A high prevalence (53 %) of undernutrition was observed in these patients. Postoperative complications such as shunt infection (P¼0·0023), shunt revision (P¼ 0·0074) and mortality (P¼ 0·0003) were significantly more common in undernourished patients compared with normally nourished patients. Serum albumin emerged as the most significant independent predictor of postoperative mortality. The present study demonstrated a high prevalence of undernutrition in hydrocephalus patients in India and its adverse influence on the outcome of shunt surgery. Early preoperative nutritional status screening and its optimisation may decrease the morbidity and mortality of shunt surgery for hydrocephalus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb59a170a70a34c87c79db7800959652" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327404,"asset_id":14316555,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327404/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316555; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3267776" id="papers"><div class="js-work-strip profile--work_container" data-work-id="14316574"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316574/High_performance_liquid_chromatography_method_for_the_pharmacokinetic_study_of_bicalutamide_SMEDDS_and_suspension_formulations_after_oral_administration_to_rats"><img alt="Research paper thumbnail of High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats" class="work-thumbnail" src="https://attachments.academia-assets.com/44327386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316574/High_performance_liquid_chromatography_method_for_the_pharmacokinetic_study_of_bicalutamide_SMEDDS_and_suspension_formulations_after_oral_administration_to_rats">High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats</a></div><div class="wp-workCard_item"><span>Talanta</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating prostate cancer. To evaluate the bioavailability of bicalutamide from bicalutamide self-microemulsifying drug delivery systems (SMEDDS) and bicalutamide suspension formulations, a sensitive, specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of bicalutamide (BCT) in rat blood plasma. Letrozole (LZ) was used as the internal standard. The chromatographic separation was achieved on C18 column at 35 degrees C, with a mobile phase consisting of water: acetonitrile (adjusted to pH 3.0 with 20% o-phosphoric acid) (60:40), at a flow rate of 1.0 mL min(-1). Bicalutamide and letrozole were well separated with retention times of 10.9+/-0.2 and 5.7+/-0.2 min, respectively. The method was successfully used to determine pharmacokinetics of bicalutamide, following oral administration of bicalutamide susp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdb72f3223267354870daaa9186389f0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327386,"asset_id":14316574,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327386/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316574"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316574"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316574; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells"><img alt="Research paper thumbnail of The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells">The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O-2/graphite cells with 1M LiPF6 EC:EMC ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Wound LiCoO2/graphite and Li[Ni0.42Mn0.42Co0.16]O-2/graphite cells with 1M LiPF6 EC:EMC electrolyte containing either 0, 1 or 2 wt.% vinylene carbonate were studied using the High Precision Charger at Dalhousie University, automated cell storage and AC impedance. Vinylene carbonate (VC) was found to improve the coulombic efficiency of the cells, decrease charge endpoint capacity slippage and decrease self discharge, in all cases primarily by slowing electrolyte oxidation at the positive electrode. The beneficial impacts of VC are greater in LiCoO2 cells than in Li[Ni0.42Mn0.42Co0.16]O-2 cells. One percent VC is enough to derive the benefits without causing an impedance rise in the cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316573]").text(description); $(".js-view-count[data-work-id=14316573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316573,"title":"The Impact of Varying the Concentration of Vinylene Carbonate Electrolyte Additive in Wound Li-Ion Cells","internal_url":"https://www.academia.edu/14316573/The_Impact_of_Varying_the_Concentration_of_Vinylene_Carbonate_Electrolyte_Additive_in_Wound_Li_Ion_Cells","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316572"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system"><img alt="Research paper thumbnail of A class of discontinuous dynamical systems IV. A laboratory air–water system" class="work-thumbnail" src="https://attachments.academia-assets.com/44327381/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system">A class of discontinuous dynamical systems IV. A laboratory air–water system</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An air-water experimental system consisting of two inlets and one outlet is constructed and chara...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An air-water experimental system consisting of two inlets and one outlet is constructed and characterised. It reaches the state of sliding mode, or equivalently, two phase slug ow. The linear hydraulic model proposed in the literature is adequate to describe it. Experimental data are used to tune this model. The resistance to the ow of air through the outlet valve during the two phase ow is much larger than that when air alone ows out. At the operating range, the resistance to water ow is not a ected by the presence of air. ?</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="955b86cbfefa3da6fcccd4bd1abee47d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327381,"asset_id":14316572,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327381/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316572"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316572"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316572; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316572]").text(description); $(".js-view-count[data-work-id=14316572]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316572; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316572']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "955b86cbfefa3da6fcccd4bd1abee47d" } } $('.js-work-strip[data-work-id=14316572]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316572,"title":"A class of discontinuous dynamical systems IV. A laboratory air–water system","internal_url":"https://www.academia.edu/14316572/A_class_of_discontinuous_dynamical_systems_IV_A_laboratory_air_water_system","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327381,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327381/thumbnails/1.jpg","file_name":"A_class_of_discontinuous_dynamical_syste20160402-27181-24hj46.pdf","download_url":"https://www.academia.edu/attachments/44327381/download_file","bulk_download_file_name":"A_class_of_discontinuous_dynamical_syste.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327381/A_class_of_discontinuous_dynamical_syste20160402-27181-24hj46-libre.pdf?1459606228=\u0026response-content-disposition=attachment%3B+filename%3DA_class_of_discontinuous_dynamical_syste.pdf\u0026Expires=1739812843\u0026Signature=HwxqJEJfcXyoTn7dNPw2swCLODq-bhWtodXguuTbLQmUnNkKEtoUIQGUfrNal1WwA2kvMmQN2XPcz080v4oGSXorzSy8HQr2pwgHvT13ouHacAlALPGXJ0sQft10dn8JqmoaDGLdn4auSUWKltrDIGJdr4Z-Qc2q1L5MbdbjmB46XLUhnkbSjdjGCaF~uIBFiur8qhw1D-ep~DYHnupKnp~-oFPmHjjvXjYjYYq~Hx7uCZHqdtJJvXYy0Zri-JtD6aTMYoCQuCoLkL5VTSXYL5v63V8926ebRZ7PGyk~3vLtbG7-VpbEEUfLNpZ2NHxabhW8s6QRF-E~MOg0bMge1w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316571"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus"><img alt="Research paper thumbnail of Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus" class="work-thumbnail" src="https://attachments.academia-assets.com/44327392/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus">Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus</a></div><div class="wp-workCard_item"><span>BMC neurology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intracranial haemorrhage accounts for 30-60 % of all stroke admissions into a hospital, with hype...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intracranial haemorrhage accounts for 30-60 % of all stroke admissions into a hospital, with hypertension being the main risk factor. Presence of intraventricular haematoma is considered a poor prognostic factor due to the resultant obstruction to CSF and the mass effect following the presence of blood resulting in raised intracranial pressure and hydrocephalus. We report the results following endoscopic decompression of obstructive hydrocephalus and evacuation of haematoma in patients with hypertensive intraventricular haemorrhage. During a two year period, 25 patients diagnosed as having an intraventricular haemorrhage with obstructive hydrocephalus secondary to hypertension were included in this study. All patients underwent endoscopic evacuation of the haematoma under general anaesthesia. Post operative evaluation was done by CT scan and Glasgow outcome scale. Of the 25 patients, thalamic haemorrhage was observed in 12 (48%) patients, while, 11 (44%) had a putaminal haematoma. N...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="97467220a7aefd9c22fe6a2c643e9c55" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327392,"asset_id":14316571,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327392/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316571"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316571; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "97467220a7aefd9c22fe6a2c643e9c55" } } $('.js-work-strip[data-work-id=14316571]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316571,"title":"Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus","internal_url":"https://www.academia.edu/14316571/Endoscopic_management_of_hypertensive_intraventricular_haemorrhage_with_obstructive_hydrocephalus","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327392,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327392/thumbnails/1.jpg","file_name":"Endoscopic_management_of_hypertensive_in20160402-32742-15hpcd7.pdf","download_url":"https://www.academia.edu/attachments/44327392/download_file","bulk_download_file_name":"Endoscopic_management_of_hypertensive_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327392/Endoscopic_management_of_hypertensive_in20160402-32742-15hpcd7-libre.pdf?1459606228=\u0026response-content-disposition=attachment%3B+filename%3DEndoscopic_management_of_hypertensive_in.pdf\u0026Expires=1739812843\u0026Signature=TDy21iJwUt1KP65xZo7c~7BQUzjvKdj3Dp32XmEZ07cOkQ8zR8SM-wW0i-mvBiLws0xtyjukAVxdko6fNVSunh2p~o9teKQnzMpXPAwUDQToD-PZaHSlENaHgYfiMsEutmffg7QcrsEvSUzdxDyAuY~B5tcRrJfL37fFGxMdjO6c5RzBJBNddKBx341qOEREASSYHnsqADBi47lIymg237aL~oNlXQ7KMKNESBO3jHohSbQTmRSIEMgqynpWNE6qvMjgP9WlUzTcgjM2nyXk7YBiaSsS9~nyJ48A6dsySGwL1qhUFqZlnUGyhD~tMtFSYof0SYQwBkOAXr-WTO2v2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316570/Mucinous_cystadenoma_A_rare_entity"><img alt="Research paper thumbnail of Mucinous cystadenoma: A rare entity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316570/Mucinous_cystadenoma_A_rare_entity">Mucinous cystadenoma: A rare entity</a></div><div class="wp-workCard_item"><span>Dental research journal</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cystadenoma is a rare benign salivary gland tumor that chiefly originates in the minor salivary g...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cystadenoma is a rare benign salivary gland tumor that chiefly originates in the minor salivary glands as a cystic growth with papillary projections into the cystic lumen without the lymphoid element. It is further classified into two histopathological variants that have been recognized by World Health Organization as the papillary and the mucinous forms of cystadenoma. Clinically, it is difficult to differentiate from other benign minor salivary tumors and mucous retention phenomenon. Diagnosis is chiefly based on characteristics histological features. It is believed that the salivary gland tumors are difficult to diagnose and interpret because there are varied patterns of presentation. The study of salivary gland disorders has increased in leaps and bounds. The authors report a case of mucinous cystadenoma of the minor salivary gland on the hard palate, which is even rarest of the rarely reported cystadenomas of the minor salivary glands.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316570,"title":"Mucinous cystadenoma: A rare entity","internal_url":"https://www.academia.edu/14316570/Mucinous_cystadenoma_A_rare_entity","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316569"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316569/Development_of_Poly_Lactide_Co_Glycolide_Nanodispersions_for_Enhanced_Ocular_Delivery_of_Moxifloxacin"><img alt="Research paper thumbnail of Development of Poly Lactide-Co-Glycolide Nanodispersions for Enhanced Ocular Delivery of Moxifloxacin" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316569/Development_of_Poly_Lactide_Co_Glycolide_Nanodispersions_for_Enhanced_Ocular_Delivery_of_Moxifloxacin">Development of Poly Lactide-Co-Glycolide Nanodispersions for Enhanced Ocular Delivery of Moxifloxacin</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/NirmalJayabalan">Nirmal Jayabalan</a></span></div><div class="wp-workCard_item"><span>Science of Advanced Materials</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT In the present work we developed and optimized moxifloxacin loaded PLGA nanodispersions ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT In the present work we developed and optimized moxifloxacin loaded PLGA nanodispersions for enhanced ocular delivery of moxifloxacin. The optimized nanodispersions were prepared by double emulsification solvent evaporation method using high pressure homogenizer (500 bar pressure, 2 cycles) to homogenize primary emulsion. Particle size of nanodispersion was found to be dependent on PLGA concentration, PLGA:drug ratio, PVA concentration and W:O phase volume ratio whereas drug encapsulation was related to PLGA concentration and PLGA:drug ratio. Encapsulation efficiency of optimized nanodispersion was 62.5% with a mean particle size of around 118.5 nm which makes them a suitable candidate for ocular administration. Drug release kinetic studies indicate a sustained release profile of moxifloxacin from nanodispersions. In addition, in vitro and in vivo studies have revealed that PLGA nanodispersions were non irritant, prevent ocular drainage of moxifloxacin with enhanced ocular bioavailability by 3-fold.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316569; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="14316568"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316568/Comparative_Evaluation_of_Local_Anaesthesia_with_Adrenaline_and_Without_Adrenaline_on_Blood_Glucose_Concentration_in_Patients_Undergoing_Tooth_Extractions"><img alt="Research paper thumbnail of Comparative Evaluation of Local Anaesthesia with Adrenaline and Without Adrenaline on Blood Glucose Concentration in Patients Undergoing Tooth Extractions" class="work-thumbnail" src="https://attachments.academia-assets.com/44327408/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316568/Comparative_Evaluation_of_Local_Anaesthesia_with_Adrenaline_and_Without_Adrenaline_on_Blood_Glucose_Concentration_in_Patients_Undergoing_Tooth_Extractions">Comparative Evaluation of Local Anaesthesia with Adrenaline and Without Adrenaline on Blood Glucose Concentration in Patients Undergoing Tooth Extractions</a></div><div class="wp-workCard_item"><span>Journal of Maxillofacial and Oral Surgery</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Lignocaine hydrochloride is the most widely used and easily available local anaestheti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Lignocaine hydrochloride is the most widely used and easily available local anaesthetic agent. Adrenaline is frequently combined with lignocaine to enhance the duration of anaesthesia, decrease toxicity, to achieve vasoconstriction and to provide a bloodless field. Aim and Objective This study was conducted to do the comparative evaluation of local anaesthesia with adrenaline and without adrenaline on blood glucose concentration in patients under going tooth extraction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae325414feda2992c8c5736d8e96341c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327408,"asset_id":14316568,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327408/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316568"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316568"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316568; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316567"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316567/AQUEOUS_PHASE_TRANSFER_OF_OLEIC_ACID_COATED_IRON_OXIDE_NANOPARTICLES_INFLUENCE_OF_SOLVENTS_AND_SURFACTANTS_ON_STABILITY_AND_PHARMACEUTICAL_APPLICATIONS_OF_FERROFLUID"><img alt="Research paper thumbnail of AQUEOUS PHASE TRANSFER OF OLEIC ACID COATED IRON OXIDE NANOPARTICLES: INFLUENCE OF SOLVENTS AND SURFACTANTS ON STABILITY AND PHARMACEUTICAL APPLICATIONS OF FERROFLUID" class="work-thumbnail" src="https://attachments.academia-assets.com/39136906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316567/AQUEOUS_PHASE_TRANSFER_OF_OLEIC_ACID_COATED_IRON_OXIDE_NANOPARTICLES_INFLUENCE_OF_SOLVENTS_AND_SURFACTANTS_ON_STABILITY_AND_PHARMACEUTICAL_APPLICATIONS_OF_FERROFLUID">AQUEOUS PHASE TRANSFER OF OLEIC ACID COATED IRON OXIDE NANOPARTICLES: INFLUENCE OF SOLVENTS AND SURFACTANTS ON STABILITY AND PHARMACEUTICAL APPLICATIONS OF FERROFLUID</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/NiluJain">Nilu Jain</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SohailAkhter1">Sohail Akhter</a></span></div><div class="wp-workCard_item"><span>Magnetohydrodynamics</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this work, iron oxide nanoparticles were prepared by a classical co-precipitation method in an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this work, iron oxide nanoparticles were prepared by a classical co-precipitation method in an inert atmosphere. In the first step, iron oxide nanoparticles were synthesized, coated with oleic acid (5-50%) and its dispersions in different organic solvents (n-hexane, n-heptane and n-octane) were prepared. In the second step, a ferrofluid was obtained by a mini-emulsion process with the aid of different surfactants: sodium dodecyl sulphate (SDS), polysorbate 20 (tween 20), sorbitan monolaurate (span 20), poloxamer 188, poloxamer 407, Polyoxyl 23 lauryl ether (brij 35), Polyoxyl 40 stearate (myrj 52), vitamin E polyethylene glycol succinate (vitamin E TPGS) and docusate sodium. Characterization of oleic acid coated iron oxide nanoparticles were done by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray powder diffraction (XRD). Stability study of the aqueous ferrofluid was performed by measuring the particle size and polydispersity index within a storage period of six months. Clinical application of ferrofluid in targeted drug delivery systems was also discussed with respect to different surfactants.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="723ba75ca450cf5cad38ad92ea3bbcda" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":39136906,"asset_id":14316567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/39136906/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316567; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316566"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery"><img alt="Research paper thumbnail of UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery">UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://iabfu.academia.edu/NiyazAhmad">Niyaz Ahmad</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A simple, sensitive and selective ultra performance liquid chromatographic (UPLC) method with qua...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A simple, sensitive and selective ultra performance liquid chromatographic (UPLC) method with quadrapole-time of flight-mass spectrometric (Q-TOF-MS/MS) detection was developed for the determination of moxifloxacin (moxi) in rabbit aqueous humor. After a simple protein-precipitation by acetonitrile, the post-treatment samples were separated on a UPLC Bridged Ethyl Hybrid (BEH) C-18 column with 0.1% formic acid in water as a mobile phase</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316566"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316566"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316566; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316566]").text(description); $(".js-view-count[data-work-id=14316566]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316566; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316566']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316566]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316566,"title":"UPLC/Q-TOF-MS/MS method for evaluation of moxifloxacin loaded nanoplexes as vehicles for ocular drug delivery","internal_url":"https://www.academia.edu/14316566/UPLC_Q_TOF_MS_MS_method_for_evaluation_of_moxifloxacin_loaded_nanoplexes_as_vehicles_for_ocular_drug_delivery","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316565"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report"><img alt="Research paper thumbnail of Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report" class="work-thumbnail" src="https://attachments.academia-assets.com/44327389/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report">Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report</a></div><div class="wp-workCard_item"><span>Journal of Maxillofacial and Oral Surgery</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment and reconstruction of oral scar contracture, is always a challenging procedure to resto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment and reconstruction of oral scar contracture, is always a challenging procedure to restore structure and functions of the oral cavity. We present a case of a patient with limited mouth opening who sustained extensive oral scar contracture with complete adhesion of tongue to floor of mouth following ingestion of caustic soda without his knowledge 4 years back. We performed a surgical release of the scar contractures from buccal mucosa on both sides, along with a release of the tongue from the floor of the mouth, followed by reconstruction of all sites using split skin grafts. Adequate mouth opening and tongue movement was achieved. There was a follow up period of 1 month with excellent mouth opening and tongue function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="784967ef802ce3fd1d7ae479d54ef940" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327389,"asset_id":14316565,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327389/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316565"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316565"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316565; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "784967ef802ce3fd1d7ae479d54ef940" } } $('.js-work-strip[data-work-id=14316565]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316565,"title":"Unusual Presentation of Caustic Ingestion and its Surgical Treatment: A Case Report","internal_url":"https://www.academia.edu/14316565/Unusual_Presentation_of_Caustic_Ingestion_and_its_Surgical_Treatment_A_Case_Report","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[{"id":44327389,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/44327389/thumbnails/1.jpg","file_name":"Unusual_presentation_of_caustic_ingestio20160402-30507-vv91iv.pdf","download_url":"https://www.academia.edu/attachments/44327389/download_file","bulk_download_file_name":"Unusual_Presentation_of_Caustic_Ingestio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/44327389/Unusual_presentation_of_caustic_ingestio20160402-30507-vv91iv-libre.pdf?1459606227=\u0026response-content-disposition=attachment%3B+filename%3DUnusual_Presentation_of_Caustic_Ingestio.pdf\u0026Expires=1739812843\u0026Signature=Af-I3~e3KR-32gzCD0gBpf2ohTSLQGquYVTVSUN751QNp3V-A5nZVqrYAgyDh5lataCO0OQzeooHweGVRXAXd7ZJBZlsP5TG7CW8MNSgQ7GutBg~H8~2kF~xP7ITIOnWjs2kVK0O~Du2EOs7gaOouxzt5p45LgAiVDmUK5Vh32c-dTWgWz9l~Knj2-04v5EIhKJThE0cC5OcqKzhPESUECyH1rTV5gtcKC75NolYS5X0DqJ4oOGaBcjBPTzjwtWif93TrsclaFtQ7OeYt-xxH2lyFBGwMDQvLlm2XBlc5GSEs3asaX3Qd7HftxL81k-RvTb84h9HowI2tsu3tfOVTA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316564"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316564/Evaluation_of_efficacy_of_arthrocentesis_with_normal_saline_with_or_without_sodium_hyaluronate_in_treatment_of_internal_derangement_of_TMJ_A_prospective_randomized_study_in_20_patients"><img alt="Research paper thumbnail of Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ – A prospective randomized study in 20 patients" class="work-thumbnail" src="https://attachments.academia-assets.com/44327415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316564/Evaluation_of_efficacy_of_arthrocentesis_with_normal_saline_with_or_without_sodium_hyaluronate_in_treatment_of_internal_derangement_of_TMJ_A_prospective_randomized_study_in_20_patients">Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ – A prospective randomized study in 20 patients</a></div><div class="wp-workCard_item"><span>Journal of Oral Biology and Craniofacial Research</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arthrocentesis Sodium hyaluronidase a b s t r a c t Purpose: To compare the outcome of arthrocent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arthrocentesis Sodium hyaluronidase a b s t r a c t Purpose: To compare the outcome of arthrocentesis alone and arthrocentesis with sodium hyaluronate in internal derangement of TMJ. Materials and methods: 20 patients of disc displacement with reduction of TMJ were randomized into 2 experimental groups. Control group of patients received arthrocentesis alone and study group of patients received arthrocentesis with sodium hyaluronate. Patients TMJ status and clinical symptoms were evaluated for 6 months follow up. The clinical parameter recorded were maximal mouth opening (MMO), lateral excursions (right and left side), protrusive movement, joint noises, and pain (at rest, at function).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="161607b8935c2d05b14cb1d7f73fb929" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327415,"asset_id":14316564,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316564"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316564"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316564; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316563/Bone_metastases_as_the_initial_presentation_of_carcinoma_of_gall_bladder_a_rarity"><img alt="Research paper thumbnail of Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity" class="work-thumbnail" src="https://attachments.academia-assets.com/44327419/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316563/Bone_metastases_as_the_initial_presentation_of_carcinoma_of_gall_bladder_a_rarity">Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity</a></div><div class="wp-workCard_item"><span>Indian Journal of Surgery</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Distant metastases are rare form of presentation of carcinoma gall bladder. Bony pain as initial ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Distant metastases are rare form of presentation of carcinoma gall bladder. Bony pain as initial presentation is quite unusual. A 50-year-old woman presented with the pain in right shoulder. Investigation showed metastatic adenocarcinoma in the head of humerus and the primary was found in the gall bladder. She received local radiotherapy for bone metastases and undergoing systemic chemotherapy. Carcinoma gall bladder is a common abdominal malignancy, mostly presenting in advanced stage with abdominal symptoms and obstructive jaundice. In presence of metastasis, the management is palliative and role of chemotherapy is limited for palliation symptoms.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c43f324e0010a1482f04a6f2247018a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327419,"asset_id":14316563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327419/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316563]").text(description); $(".js-view-count[data-work-id=14316563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits"><img alt="Research paper thumbnail of Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits">Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a></span></div><div class="wp-workCard_item"><span>Colloids and Surfaces B: Biointerfaces</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Poor drug penetration and rapid clearance after topical instillation of a drug formulation into t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Poor drug penetration and rapid clearance after topical instillation of a drug formulation into the eyes are the major causes for the lower ocular bioavailability from conventional eye drops. Along with this, poor encapsulation efficiency of hydrophilic drug in polymeric nanoparticles remains a major formulation challenge. Taking this perspective into consideration, dorzolamide (DZ)-loaded PLGA nanoparticles were developed employing two different emulsifiers (PVA and vitamin E TPGS) and the effects of various formulation and process variables on particle size and encapsulation efficiency were assessed. Nanoparticles emulsified with vitamin E TPGS (DZ-T-NPs) were found to possess enhanced drug encapsulation (59.8±6.1%) as compared to those developed with PVA as emulsifier (DZ-P-NPs). Transcorneal permeation study revealed a significant enhancement in permeation (1.8-2.5 fold) as compared to solution. In addition, ex vivo biodistribution study showed a higher concentration of drug in the aqueous humour (1.5-2.3 fold). Histological and IR-camera studies proved the non-irritant potential of the formulations. Pharmacoscintigraphic studies revealed the reduced corneal clearance, as well as naso-lachrymal drainage in comparison to drug solution. Furthermore, efficacy study revealed that DZ-P-NPs and DZ-T-NPs significantly reduced the intraocular pressure by 22.81% and 29.12%, respectively, after a single topical instillation into the eye.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316562,"title":"Dorzolamide-loaded PLGA/vitamin E TPGS nanoparticles for glaucoma therapy: Pharmacoscintigraphy study and evaluation of extended ocular hypotensive effect in rabbits","internal_url":"https://www.academia.edu/14316562/Dorzolamide_loaded_PLGA_vitamin_E_TPGS_nanoparticles_for_glaucoma_therapy_Pharmacoscintigraphy_study_and_evaluation_of_extended_ocular_hypotensive_effect_in_rabbits","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316561/A_review_on_the_strategies_for_oral_delivery_of_proteins_and_peptides_and_their_clinical_perspectives"><img alt="Research paper thumbnail of A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/44327429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316561/A_review_on_the_strategies_for_oral_delivery_of_proteins_and_peptides_and_their_clinical_perspectives">A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FarhanAhmad77">Farhan Ahmad</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a></span></div><div class="wp-workCard_item"><span>Saudi Pharmaceutical Journal</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the modern world, a number of therapeutic proteins such as vaccines, antigens, and hormones are being developed utilizing different sophisticated biotechnological techniques like recombinant DNA technology and protein purification. However, the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. These problems can be overcome by adopting techniques such as chemical transformation of protein structures, enzyme inhibitors, mucoadhesive polymers and permeation enhancers. Being invasive, parenteral route is inconvenient for the administration of protein and peptides, several research endeavors have been undertaken to formulate a better delivery system for proteins and peptides with major emphasis on non-invasive routes such as oral, transdermal, vaginal, rectal, pulmonary and intrauterine. This review article emphasizes on the recent advancements made in the delivery of protein and peptides by a non-invasive (peroral) route into the body.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="80629653f68bd649c3bc1b3a5b130aa4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327429,"asset_id":14316561,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327429/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316561; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316560"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316560/An_encyclopedia_of_mouse_DNA_elements_Mouse_ENCODE_"><img alt="Research paper thumbnail of An encyclopedia of mouse DNA elements (Mouse ENCODE)" class="work-thumbnail" src="https://attachments.academia-assets.com/44327396/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316560/An_encyclopedia_of_mouse_DNA_elements_Mouse_ENCODE_">An encyclopedia of mouse DNA elements (Mouse ENCODE)</a></div><div class="wp-workCard_item"><span>Genome Biology</span><span>, 2012</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="07268a8146c95a8967f9705896b2bf0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327396,"asset_id":14316560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327396/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316560; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316560]").text(description); $(".js-view-count[data-work-id=14316560]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316560; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316560']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316559/Dental_Therapeutic_Systems"><img alt="Research paper thumbnail of Dental Therapeutic Systems" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316559/Dental_Therapeutic_Systems">Dental Therapeutic Systems</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/NiluJain">Nilu Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://omc.academia.edu/AlkaAhuja">Alka Ahuja</a></span></div><div class="wp-workCard_item"><span>Recent Patents on Drug Delivery & Formulation</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The recognition of periodontal diseases as amenable to local antibiotherapy has resulted in a par...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The recognition of periodontal diseases as amenable to local antibiotherapy has resulted in a paradigmatic shift in treatment modalities of dental afflictions. Moreover the presence of antimicrobial resistance, surfacing of untoward reactions owing to systemic consumption of antibiotics has further advocated the use of local delivery of physiologically active substances into the periodontal pocket. While antimicrobials polymerized into acrylic strips, incorporated into biodegradable collagen and hollow permeable cellulose acetate fibers, multiparticulate systems, bio-absorbable dental materials, biodegradable gels/ointments, injectables, mucoadhesive microcapsules and nanospheres will be more amenable for direct placement into the periodontal pockets the lozenges, buccoadhesive tablets, discs or gels could be effectively used to mitigate the overall gingival inflammation. Whilst effecting controlled local delivery of a few milligram of an antibacterial agent within the gingival crevicular fluid for a longer period of time, maintaining therapeutic concentrations such delivery devices will circumvent all adverse effects to non- oral sites. Since the pioneering efforts of Goodson and Lindhe in 1989, delivery at gingival and subgingival sites has witnessed a considerable progress. The interest in locally active systems is evident from the patents being filed and granted. The present article shall dwell in reviewing the recent approaches being proffered in the field. Patents as by Shefer, et al. US patent, 6589562 dealing with multicomponent biodegradable bioadhesive controlled release system for oral care products, Lee, et al. 2001, US patent 6193994, encompassing a locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof and method of treating periodontal disease as suggested by Basara in 2004via US patent 6830757, shall be the types of intellectual property reviewed and presented in the current manuscript.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316559]").text(description); $(".js-view-count[data-work-id=14316559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316559,"title":"Dental Therapeutic Systems","internal_url":"https://www.academia.edu/14316559/Dental_Therapeutic_Systems","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316558/CNS_Drug_Delivery_Systems_Novel_Approaches"><img alt="Research paper thumbnail of CNS Drug Delivery Systems: Novel Approaches" class="work-thumbnail" src="https://attachments.academia-assets.com/44327400/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316558/CNS_Drug_Delivery_Systems_Novel_Approaches">CNS Drug Delivery Systems: Novel Approaches</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://ankitkumar.academia.edu/DivyaVohra">Divya Vohora</a></span></div><div class="wp-workCard_item"><span>Recent Patents on Drug Delivery & Formulation</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielde...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The brain is a delicate organ, and nature has very efficiently protected it. The brain is shielded against potentially toxic substances by the presence of two barrier systems: the blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Despite aggressive research, patients suffering from fatal and/or debilitating central nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy, cerebrovascular diseases and neurodegenerative disorders, far outnumber those dying of all types of systemic cancers or heart diseases. The abysmally low number of potential therapeutics reaching commercial success is primarily due to the complexity of the CNS drug development. The clinical failure of many probable candidates is often, ascribable to poor delivery methods which do not pervade the unyielding BBB. It restricts the passive diffusion of many drugs into the brain and constitutes a significant obstacle in the pharmacological treatment of central nervous system (CNS) disorders. General methods that can enhance drug delivery to the brain are, therefore, of great pharmaceutical interest. Various strategies like non-invasive methods, including drug manipulation encompassing transformation into lipophilic analogues, prodrugs, chemical drug delivery, carrier-mediated drug delivery, receptor/vector mediated drug delivery and intranasal drug delivery, which exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain, are widely used. On the other hand the invasive methods which primarily rely on disruption of the BBB integrity by osmotic or biochemical means, or direct intracranial drug delivery by intracerebroventricular, intracerebral or intrathecal administration after creating reversible openings in the head, are recognised. Extensive review pertaining specifically, to the patents relating to drug delivery across the CNS is currently available. However, many patents e.g. US63722506, US2002183683 etc., have been mentioned in a few articles. It is the objective of this article to expansively review drug delivery systems for CNS by discussing the recent patents available.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8a8ede30271f567fa403562e7d8ebb58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327400,"asset_id":14316558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327400/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316558; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases"><img alt="Research paper thumbnail of Argemone mexicana poisoning: autopsy findings of two cases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases">Argemone mexicana poisoning: autopsy findings of two cases</a></div><div class="wp-workCard_item"><span>Forensic Science International</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epidemic dropsy, a disease due to Argemone mexicana poisoning, is characterized by pathological a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epidemic dropsy, a disease due to Argemone mexicana poisoning, is characterized by pathological accumulation of diluted lymph in body tissues and cavities. Recently, the largest epidemic of the disease in India affected Delhi and its neighboring states during the months of August–September 1998. Over 3000 persons fell ill, and more than 65 died in the state of Delhi alone. Two</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316557"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316557"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316557; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316557]").text(description); $(".js-view-count[data-work-id=14316557]").attr('title', description).tooltip(); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316557]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316557,"title":"Argemone mexicana poisoning: autopsy findings of two cases","internal_url":"https://www.academia.edu/14316557/Argemone_mexicana_poisoning_autopsy_findings_of_two_cases","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS"><img alt="Research paper thumbnail of ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS">ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/GauravJain96">Gaurav Jain</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MusarratWarsi">Musarrat Warsi</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RoopKhar">Roop Khar</a></span></div><div class="wp-workCard_item"><span>Journal of Liquid Chromatography & Related Technologies</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To evaluate the bioavailability of exemestane (EXM) from self-microemulsifying drug delivery syst...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To evaluate the bioavailability of exemestane (EXM) from self-microemulsifying drug delivery systems (SMEDDS) and suspension formulations, a sensitive, specific and rapid liquid chromatography–mass spectrometric method was developed and validated. The analyte was extracted from plasma samples and detected by mass spectrometry with an atmospheric pressure positive-ion chemical ionization (APCI) mode using a heated nebulizer interface. Progesterone (PGS) was used as</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14316556]").text(description); $(".js-view-count[data-work-id=14316556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14316556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14316556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14316556]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14316556,"title":"ORAL PHARMACOKINETIC STUDY OF EXEMESTANE SMEDDS AND SUSPENSION IN RAT PLASMA BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS","internal_url":"https://www.academia.edu/14316556/ORAL_PHARMACOKINETIC_STUDY_OF_EXEMESTANE_SMEDDS_AND_SUSPENSION_IN_RAT_PLASMA_BY_LIQUID_CHROMATOGRAPHY_MASS_SPECTROMETRIC_ANALYSIS","owner_id":33270193,"coauthors_can_edit":true,"owner":{"id":33270193,"first_name":"Gaurav","middle_initials":null,"last_name":"Jain","page_name":"GauravJain96","domain_name":"independent","created_at":"2015-07-22T20:27:04.270-07:00","display_name":"Gaurav Jain","url":"https://independent.academia.edu/GauravJain96"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14316555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14316555/The_impact_of_nutritional_status_on_the_outcome_of_Indian_patients_undergoing_neurosurgical_shunt_surgery"><img alt="Research paper thumbnail of The impact of nutritional status on the outcome of Indian patients undergoing neurosurgical shunt surgery" class="work-thumbnail" src="https://attachments.academia-assets.com/44327404/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14316555/The_impact_of_nutritional_status_on_the_outcome_of_Indian_patients_undergoing_neurosurgical_shunt_surgery">The impact of nutritional status on the outcome of Indian patients undergoing neurosurgical shunt surgery</a></div><div class="wp-workCard_item"><span>British Journal of Nutrition</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Undernutrition is common in surgical patients, is frequently unrecognised and is strongly associa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Undernutrition is common in surgical patients, is frequently unrecognised and is strongly associated with adverse outcomes such as high rates of complications and mortality, worsening functional status and prolonged hospitalisation. Owing to the associated infection and symptoms such as repeated vomiting, a high prevalence of undernutrition is expected in hydrocephalus patients, which may contribute to their poor surgical outcomes. The aim of this study was to evaluate the influence of preoperative nutritional status on the outcome of Indian patients with hydrocephalus undergoing neurosurgical shunt surgery. One hundred and twenty-four consecutive patients undergoing scheduled hydrocephalus shunt surgery were studied prospectively. All patients underwent nutritional screening according to different parameters prior to surgery. The patients were classified into normally nourished and undernourished groups. The undernourished group was further subdivided into moderately and severely undernourished. The surgical outcome was compared between these groups. A high prevalence (53 %) of undernutrition was observed in these patients. Postoperative complications such as shunt infection (P¼0·0023), shunt revision (P¼ 0·0074) and mortality (P¼ 0·0003) were significantly more common in undernourished patients compared with normally nourished patients. Serum albumin emerged as the most significant independent predictor of postoperative mortality. The present study demonstrated a high prevalence of undernutrition in hydrocephalus patients in India and its adverse influence on the outcome of shunt surgery. Early preoperative nutritional status screening and its optimisation may decrease the morbidity and mortality of shunt surgery for hydrocephalus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb59a170a70a34c87c79db7800959652" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44327404,"asset_id":14316555,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44327404/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14316555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14316555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14316555; 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