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data-dom-id="Pill-react-component-20014620-96bc-4959-8e8a-7478c11dba91"></div> <div id="Pill-react-component-20014620-96bc-4959-8e8a-7478c11dba91"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="5436993" href="https://www.academia.edu/Documents/in/Education"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Education"]}" data-trace="false" data-dom-id="Pill-react-component-41551125-1c73-4a7d-8d9a-363702d78f71"></div> <div id="Pill-react-component-41551125-1c73-4a7d-8d9a-363702d78f71"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Nayanabhirama Udupa</h3></div><div class="js-work-strip profile--work_container" data-work-id="4426632"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies"><img alt="Research paper thumbnail of Multiparticulate drug delivery system of aceclofenac: development and in vitro studies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies">Multiparticulate drug delivery system of aceclofenac: development and in vitro studies</a></div><div class="wp-workCard_item"><span>Drug development and industrial pharmacy</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90-95%. The particle size of enteric-coated pellets was found to be in the range of 0.59-0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5%) for a period of 2 h, and at pH 6.8, it shows the maximum release (85 +/- 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated pellets were compared to that of marketed product (tablets), it was observed that pellets showed better release profile. The study concluded that the formulated multiparticulate dosage forms can be used as an ideal drug delivery system for the aceclofenac.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426632"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426632"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426632; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426632]").text(description); $(".js-view-count[data-work-id=4426632]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426632; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426632']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426632]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426632,"title":"Multiparticulate drug delivery system of aceclofenac: development and in vitro studies","internal_url":"https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426631"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426631/Development_of_mucoadhesive_buccal_films_for_the_treatment_of_oral_sub_mucous_fibrosis_a_preliminary_study"><img alt="Research paper thumbnail of Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study" class="work-thumbnail" src="https://attachments.academia-assets.com/49867999/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426631/Development_of_mucoadhesive_buccal_films_for_the_treatment_of_oral_sub_mucous_fibrosis_a_preliminary_study">Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study</a></div><div class="wp-workCard_item"><span>Pharmaceutical development and technology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective of the present study was to develop the mucoadhesive buccal film of valdecoxib for ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective of the present study was to develop the mucoadhesive buccal film of valdecoxib for the treatment of oral sub mucous fibrosis, a localized buccal disease. Valdecoxib, a novel COX-2 inhibitor has been reported to be used in various osteopathic and rheumatoid conditions as oral therapy. The films were made out of chitosan and HPMC K4M as polymers. Sodium taurocholate was used as a permeation enhancer. All the formulations were examined for film thickness, swelling properties, drug content, weight variation, in vitro release studies, bioadhesive force, tensile strength, diffusion studies using pig mucosa and pharmacokinetic study in healthy male volunteers. Prepared films were thin, flexible, smooth and transparent. Bioadhesive force and tensile strength of the optimized formulation were found to be 75 ± 4 kg m −1 S −2 and more than 2.5 kg/3 cm 2 , respectively. The percent drug content was 98.5 ± 1.3%. The in vitro drug release from the selected formulation showed that about 69.34% of the drug payload was released up to 6 hours. The drug permeation through the dialysis sac and pig buccal mucosa was found to be 62.70% and 54.39%, respectively. Pharmacokinetic studies of the buccal mucoadhesive film showed that the drug was released locally at the target site of action, and a very small amount might have absorbed systemically.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbac9ac7ecdf39d0c3e5a244968f28b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49867999,"asset_id":4426631,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49867999/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426631"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426631; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426630"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426630/Preparation_in_vitro_characterization_pharmacokinetic_and_pharmacodynamic_evaluation_of_chitosan_based_plumbagin_microspheres_in_mice_bearing_B16F1_melanoma"><img alt="Research paper thumbnail of Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma" class="work-thumbnail" src="https://attachments.academia-assets.com/49868279/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426630/Preparation_in_vitro_characterization_pharmacokinetic_and_pharmacodynamic_evaluation_of_chitosan_based_plumbagin_microspheres_in_mice_bearing_B16F1_melanoma">Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma</a></div><div class="wp-workCard_item"><span>Drug delivery</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1650af3b3c0bbdb16565c7c57419267e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868279,"asset_id":4426630,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868279/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426630]").text(description); $(".js-view-count[data-work-id=4426630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426629/Chitosan_and_enteric_polymer_based_once_daily_sustained_release_tablets_of_aceclofenac_in_vitro_and_in_vivo_studies"><img alt="Research paper thumbnail of Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies" class="work-thumbnail" src="https://attachments.academia-assets.com/49868008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426629/Chitosan_and_enteric_polymer_based_once_daily_sustained_release_tablets_of_aceclofenac_in_vitro_and_in_vivo_studies">Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies</a></div><div class="wp-workCard_item"><span>AAPS PharmSciTech</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of this study was to develop a once daily sustained release tablet of aceclofenac usi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of this study was to develop a once daily sustained release tablet of aceclofenac using chitosan and an enteric coating polymer (hydroxypropyl methylcellulose phthalate or cellulose acetate phthalate). Overall sustained release for 24 h was achieved by preparing a double-layer tablet in which the immediate release layer was formulated for a prompt release of the drug and the sustained release layer was designed to achieve a prolonged release of drug. The preformulation studies like IR spectroscopic and differential scanning calorimetry showed the absence of drug–excipient interactions. The tablets were found within the permissible limits for various physicochemical parameters. Scanning electron microscopy was used to visualize the surface morphology of the tablets and to confirm drug release mechanisms. Good equivalence in the drug release profile was observed when drug release pattern of the tablet containing chitosan and hydroxypropyl methylcellulose phthalate (M-7) was compared with that of marketed tablet. The optimized tablets were stable at accelerated storage conditions for 6 months with respect to drug content and physical appearance. The results of pharmacokinetic studies in human volunteers showed that the optimized tablet (M-7) exhibited no difference in the in vivo drug release in comparison with marketed tablet. No significant difference between the values of pharmacokinetic parameters of M-7 and marketed tablets was observed (p > 0.05; 95% confidence intervals). However the clinical studies in large scale and, long term and extensive stability studies at different conditions are required to confirm these results.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6898c6fa8abf9b6278dc131207c1cac2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868008,"asset_id":4426629,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868008/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426629; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426626/Protective_Role_of_Catechin_on_d_Galactosamine_Induced_Hepatotoxicity_Through_a_p53_Dependent_Pathway"><img alt="Research paper thumbnail of Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/49868004/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426626/Protective_Role_of_Catechin_on_d_Galactosamine_Induced_Hepatotoxicity_Through_a_p53_Dependent_Pathway">Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway</a></div><div class="wp-workCard_item"><span>Indian journal of clinical biochemistry : IJCB</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective of this study was to obtain a better understanding of the mechanism responsible for the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity. Catechin 50 and 100 mg/kg b.wt was administered for 1 week by oral route. Liver damage was induced by intra-peritoneal administration of 400 mg/kg b.wt d-galactosamine on the last day of catechin treatment. At the end of treatment all animals were killed and liver enzyme levels were estimated. Dissected hepatic samples were used for histopathology, RNA isolation, expression studies of Bax, Bcl-2 and p53 mRNA levels and mitochondrial membrane potential studies. We found that increases in the liver enzyme activity and decrease in antioxidant enzyme activity by d-GalN were significantly restricted by oral pretreatment with catechin. Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1966ef341a259eabe62cc1b053fd20bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868004,"asset_id":4426626,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868004/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426626; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426622/Size_controlled_synthesis_of_biocompatible_gold_nanoparticles_and_their_activity_in_the_oxidation_of_NADH"><img alt="Research paper thumbnail of Size controlled synthesis of biocompatible gold nanoparticles and their activity in the oxidation of NADH" class="work-thumbnail" src="https://attachments.academia-assets.com/49868002/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426622/Size_controlled_synthesis_of_biocompatible_gold_nanoparticles_and_their_activity_in_the_oxidation_of_NADH">Size controlled synthesis of biocompatible gold nanoparticles and their activity in the oxidation of NADH</a></div><div class="wp-workCard_item"><span>Nanotechnology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Size and shape controlled synthesis remains a major bottleneck in the research on nanoparticles e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Size and shape controlled synthesis remains a major bottleneck in the research on nanoparticles even after the development of different methods for their preparation. By tuning the size and shape of a nanoparticle, the intrinsic properties of the nanoparticle can be controlled leading tremendous potential applications in different fields of science and technology. We describe a facile route for the one pot synthesis of gold nanoparticles in water using monosodium glutamate as the reducing and stabilizing agent in the absence of seed particles. The particle diameter can be easily controlled by varying the pH of the reaction medium. Nanoparticles were characterized using scanning electron microscopy, UV-vis absorption spectroscopy, cyclic voltammetry, and dynamic light scattering. Zeta potential measurements were made to compare the stability of the different nanoparticles. The results suggest that lower pH favours a nucleation rate giving rise to smaller particles and higher pH favours a growth rate leading to the formation of larger particles. The synthesized nanoparticles are found to be stable and biocompatible. The nanoparticles synthesized at high pH exhibited a good electrocatalytic activity towards oxidation of nicotinamide adenine dinucleotide (NADH).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db91ddf386fe6cb2679c659f29fc037f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868002,"asset_id":4426622,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868002/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426622"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426622"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426622; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426619"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426619/Solid_dispersions_a_review"><img alt="Research paper thumbnail of Solid dispersions: a review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426619/Solid_dispersions_a_review">Solid dispersions: a review</a></div><div class="wp-workCard_item"><span>Pakistan journal of pharmaceutical sciences</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Solid dispersions have attracted considerable interest as an efficient means of improving the dis...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions and recent revival has been considered.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426619]").text(description); $(".js-view-count[data-work-id=4426619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426619,"title":"Solid dispersions: a review","internal_url":"https://www.academia.edu/4426619/Solid_dispersions_a_review","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation"><img alt="Research paper thumbnail of A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation" class="work-thumbnail" src="https://attachments.academia-assets.com/49868041/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation">A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation</a></div><div class="wp-workCard_item"><span>European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Catechin is a known hepatoprotective and anticancer agent but has limited bioavailability. Its ap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Catechin is a known hepatoprotective and anticancer agent but has limited bioavailability. Its apoptotic signaling pathway in human hepatocellular carcinoma is vaguely explored. Thus, this study was designed to explore cytotoxicity by MTT assay, induction of apoptosis via DNA fragmentation, nuclear staining, bivariate flow cytometric analysis using annexin V-FITC and propidium iodide, cell cycle analysis and apoptotic markers by RT-PCR and western blotting in HepG2 cells. To increase the bioavailability and selectivity to cancer cells, various liposomes of catechin viz., conventional, charged and PEGylated forms were prepared by film hydration method and evaluated for cytotoxicity in vitro in HepG2 cells and in in vivo in EAC-induced liquid tumor model. Catechin and catechin liposomes inhibited the growth of HepG2 cell lines at concentrations 100-200 lg mL À1 depending on the length of exposure. It induced apoptosis and inhibited G 2 /M phase in cell cycle analysis. Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells. Catechin and its liposomal formulation, at a dose of 200 mg/kg body weight was found to be significantly (p < 0.05) effective in inhibiting percentage increase in body weight and enhancing the mean survival time. Deviated hematological parameters, antioxidant parameters (superoxide dismutase, catalase and lipid peroxidation) and LFT in tumor bearing mice were found to be significantly (p < 0.05) restored towards normal after treatment with catechin and its liposomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3d5d78b4ee8048d6dc98502123e76437" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868041,"asset_id":4426618,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868041/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426618]").text(description); $(".js-view-count[data-work-id=4426618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3d5d78b4ee8048d6dc98502123e76437" } } $('.js-work-strip[data-work-id=4426618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426618,"title":"A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation","internal_url":"https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868041,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868041/thumbnails/1.jpg","file_name":"A_study_on_the_role_of_-catechin_in_su20161025-30797-t5f8l1.pdf","download_url":"https://www.academia.edu/attachments/49868041/download_file","bulk_download_file_name":"A_study_on_the_role_of_catechin_in_suppr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868041/A_study_on_the_role_of_-catechin_in_su20161025-30797-t5f8l1-libre.pdf?1477439731=\u0026response-content-disposition=attachment%3B+filename%3DA_study_on_the_role_of_catechin_in_suppr.pdf\u0026Expires=1740046359\u0026Signature=AqWK92xgpvGJ6WxyTuLGOrL1dWWWB03zHQIjWf1SJKJPOTlF-K7gEWhyQOZeTmpTghoI57Ph8VviZGHuzPt-bI~rHrzwN1HuOsM7ywQV9bpe~JnPQUb9kZZHW-fo8BiYXDWTmC5HoJJcTZUGKy0FVkBZVUvNjK~BWlH0XWNZAsFcasXeeL3E5Ui-H4BEVbpV5vynR~4O0uC6TtRG9w-VLgFKzfjNYhn9APoowP3XBh11b7NtpcQ-Nm2cjI~cdON1ia~g8CQbQMnQkJO2FOhksAJF7bNcA80XvTfFQt6EGlRmB02BbJXP9QnvtYeAdxJZZBndF3RVILy2eoefixyexg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426617"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system"><img alt="Research paper thumbnail of Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system" class="work-thumbnail" src="https://attachments.academia-assets.com/49868000/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system">Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system</a></div><div class="wp-workCard_item"><span>Journal of controlled release : official journal of the Controlled Release Society</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulations with constant/programmable delivery rates make it possible to deliver drug at definite time or controlled rate in chronopharmacokinetic studies. The prepared system contained swellable polymer (L-hydroxypropyl cellulose (L-HPC), xanthan gum, polyethylene oxide or sodium alginate) together with drug tablet and erodible tablet (L-HPC or guar gum) in a pre-coated capsule. Various formulation factors were investigated through series of tests, in vitro dissolution and ex vivo continuous dissolution-absorption studies. We found that the type, amount of polymers and erodible tablet influenced the drug release. The formulation containing 200 mg sodium alginate and erodible tablet (150 mg) containing 50% guar gum and 46% lactose showed 5-6 h lag time and 10 ± 2.1% drug release in initial 6 h following rapid release (99 ± 1.7% release in 12 h) of drug was observed. The continuous dissolutionabsorption study conducted using everted rat intestinal segment indicated delay in absorption of drug. Thus this approach can provide a useful means for timed release of valsartan and may be helpful for patients with morning surge.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="179609b32ad26368653f251753fb82ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868000,"asset_id":4426617,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868000/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426617"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426617"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426617; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426617]").text(description); $(".js-view-count[data-work-id=4426617]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426617; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426617']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "179609b32ad26368653f251753fb82ab" } } $('.js-work-strip[data-work-id=4426617]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426617,"title":"Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system","internal_url":"https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868000/thumbnails/1.jpg","file_name":"Chronotherapeutic_drug_delivery_for_earl20161025-30797-i5lvf7.pdf","download_url":"https://www.academia.edu/attachments/49868000/download_file","bulk_download_file_name":"Chronotherapeutic_drug_delivery_for_earl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868000/Chronotherapeutic_drug_delivery_for_earl20161025-30797-i5lvf7-libre.pdf?1477439746=\u0026response-content-disposition=attachment%3B+filename%3DChronotherapeutic_drug_delivery_for_earl.pdf\u0026Expires=1740046359\u0026Signature=D4yXeEewbXeXgtoF71sgIEm7FAggiuEGnwZ7Muwya8yj5Qsx-xPt7stmauV78ddIWhssePAawL-NN-EMuAHfl8Y44PEYC4cj3RzbeR8a1WruHiHvRCbgPTQNneM6mD26FV61bBWTWhm2cbN4bKADlln7kSdRX9h3ARzMqWdp5EwJt~VBf6F2XYX0S-ahoXEusqLIe7NZwrjQsKIpHsd0tCYD4WakB4fMVvlWT7vP44dFVD342zBg2Ve3P8WlJz~cSBEVMhMint1FTFgETOh4FCczCADrIxg6fGztKVH-y-fNh1Enl1eUtCokHxRuSZH0EI8Rib0lASjd77zigvHciQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426616"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies"><img alt="Research paper thumbnail of Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies" class="work-thumbnail" src="https://attachments.academia-assets.com/49868005/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies">Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies</a></div><div class="wp-workCard_item"><span>Integrative cancer therapies</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study aimed at evaluating the anticancer and radiosensitizing potential of juglone ag...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study aimed at evaluating the anticancer and radiosensitizing potential of juglone against a chemoresistant and radioresistant tumor (B16F1 melanoma) growing on C57BL/6J mice. Volume doubling time, growth delay, and median survival were used to assess the in vivo anticancer and radiosensitizing potential of juglone. In vitro radiosensitizing potential of juglone was studied using clonogenic, comet, and reactive oxygen species induction assays. Treatment of tumor-bearing mice with sublethal doses of juglone caused a dose-dependent inhibition of tumor growth as evident from the growth delay and median survival values. Comet assay using tumor tissue and blood showed differential toxicity of juglone, where higher levels of DNA damage was seen in tumor tissue compared with blood cells. Pretreatment of tumor-bearing mice with optimum dose of juglone before radiation resulted in significant tumor growth inhibition compared with radiation alone. From the clonogenic assay, the authors observed a sensitization enhancement ratio of 1.37 for the combination treatment compared with radiation alone. Furthermore, comet assay studies revealed the potential of juglone to enhance the radiation-induced DNA damage and cause a delay in its repair. Juglone pretreatment before radiation also resulted in a significant elevation in the intracellular reactive oxygen species levels compared with radiation alone. In conclusion, the results of this study show the potential of juglone to inhibit the growth of melanoma in vivo. The study also revealed the potential of juglone to augment the radiation-induced cell death of melanoma cells, which may be attributed to oxidative stress-mediated DNA damage and its delayed repair.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d357c55d350fb85b004591eba5b58e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868005,"asset_id":4426616,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868005/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426616"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426616"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426616; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426616]").text(description); $(".js-view-count[data-work-id=4426616]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426616; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426616']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1d357c55d350fb85b004591eba5b58e4" } } $('.js-work-strip[data-work-id=4426616]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426616,"title":"Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies","internal_url":"https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868005,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868005/thumbnails/1.jpg","file_name":"Tumor_growth_inhibitory_effect_of_juglon20161025-30797-1lrd4du.pdf","download_url":"https://www.academia.edu/attachments/49868005/download_file","bulk_download_file_name":"Tumor_growth_inhibitory_effect_of_juglon.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868005/Tumor_growth_inhibitory_effect_of_juglon20161025-30797-1lrd4du-libre.pdf?1477439745=\u0026response-content-disposition=attachment%3B+filename%3DTumor_growth_inhibitory_effect_of_juglon.pdf\u0026Expires=1740046359\u0026Signature=cRzdaVQdt5RXk0Xm-Aha1xBvJXDcbiqbIc16rfC9gT8HlT~vSw6yHorrKpW-mG7tuK7JrOKJMWFuJOH~wK0rlpOa6F3OjQPfBedGuoRhiyC1lMEG6zs56oteEXFg-gExp8iSjQjenZXG3a81yqxwgKNezVjBI91hEdJRoMpivSUmVP50H6piwtjPcU8boUw4YG3503rCXF6C~csFP4dujukOnJfXAQ1Kdb9XkqkVpc87br-8l8NTHvncDrv0LxO~mzxaFB4IhstChOTnmbY3jHaDRaS6A~8ZF04VoIgdzGrEJT4yY1uay2y9oJa0P-jH-PrpgbfUiGIv9r0E0CDqXQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin"><img alt="Research paper thumbnail of Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin" class="work-thumbnail" src="https://attachments.academia-assets.com/49868003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin">Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin</a></div><div class="wp-workCard_item"><span>Biopharmaceutics & drug disposition</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most known interactions between herbal extracts and drugs involve the inhibition of drug-metaboli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most known interactions between herbal extracts and drugs involve the inhibition of drug-metabolizing enzymes, but little is yet known about the possible role of transporters in these interactions. In order to evaluate the effect of one of such prominent flavonoids, morin, on P-glycoprotein related efflux carriers, measurements of transport characteristics through Ussing chambers, in situ perfusion and in vivo drug absorption studies were performed with the transported, yet not metabolized model compound talinolol.This study investigated the effects of orally administered morin (1.0, 2.5 and 5.0 mg kg−1), on the pharmacokinetics of orally (10 mg kg−1) and intravenously (1.0 mg kg−1) administered talinolol in rats. In the presence of morin, the pharmacokinetic parameters of talinolol were significantly altered in the oral group but not in the intravenous group. The presence of 2.5 and 5.0 mg kg−1 of morin significantly increased (1.8–2.0 fold, p<0.01) the area under the plasma concentration–time curve and the peak plasma concentration (2.3–3.0 fold, p<0.01) of orally administered talinolol. The absolute bioavailability (F %) of talinolol in the rats pretreated with morin was significantly higher (89.09–98.29%, p<0.01) than the control (52.14%). Talinolol demonstrated asymmetric transport across rat ileum with significantly greater basolateral-to-apical (B–A) permeability than that in the apical-to-basolateral (A–B) direction. The addition of morin resulted in a concentration dependent effect, especially on the secretory transport of talinolol.The present study demonstrates that morin bears the ability to interfere with secretory intestinal transport processes. This might be due to an interaction with P-glycoprotein. Copyright © 2010 John Wiley & Sons, Ltd.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b87de30e6039fc2cef876b9a3743a36" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868003,"asset_id":4426615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868003/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426615]").text(description); $(".js-view-count[data-work-id=4426615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b87de30e6039fc2cef876b9a3743a36" } } $('.js-work-strip[data-work-id=4426615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426615,"title":"Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin","internal_url":"https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868003,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868003/thumbnails/1.jpg","file_name":"Pre-clinical_evidence_of_enhanced_oral_b20161025-30800-uhgdbb.pdf","download_url":"https://www.academia.edu/attachments/49868003/download_file","bulk_download_file_name":"Pre_clinical_evidence_of_enhanced_oral_b.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868003/Pre-clinical_evidence_of_enhanced_oral_b20161025-30800-uhgdbb-libre.pdf?1477439745=\u0026response-content-disposition=attachment%3B+filename%3DPre_clinical_evidence_of_enhanced_oral_b.pdf\u0026Expires=1740046359\u0026Signature=SVYFUXp-1Pucj68Ky-Cr~Lfgpq1qth0BCf2xGLSdYSG5hzEhp4URniogawoag6g0-6ibozsEyoZEM8XkniQ0Vb2p7AVcVRORK4O2W2VccNG8DnJclhdnRxxE8~fA6t95lqR4iJCDNHnoibu0PpvGVKL3EUA3kBs8TmgeIld3Jo7snTA5dMRCbWSBsUqSRWWU~iFSYO9r7yZt~0l~6Zo76f1jupo1rS-NX~Aia9sJ4bGsL~L6kd4iVXMxEo5CrV9VBFCq53ctcPbmOKkpABsOp7mxzKWSibSc~qBs0g4DBv~g8RVuJ95fTYTdzgFqPaZuEjyGu9ueZtH2VysW1nG9YA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426614/Preparation_and_in_vitro_preclinical_and_clinical_studies_of_aceclofenac_spherical_agglomerates"><img alt="Research paper thumbnail of Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates" class="work-thumbnail" src="https://attachments.academia-assets.com/49868011/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426614/Preparation_and_in_vitro_preclinical_and_clinical_studies_of_aceclofenac_spherical_agglomerates">Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates</a></div><div class="wp-workCard_item"><span>European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aceclofenac agglomerates were prepared by spherical crystallization technique using a three solve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aceclofenac agglomerates were prepared by spherical crystallization technique using a three solvent system comprising acetone: dichloromethane (DCM): water (bridging liquid, good solvent and bad solvent, respectively). Hydroxypropyl methylcellulose-50 cps (HPMC) in different concentrations was used as hydrophilic polymer. The effect of speed of rotation and amount of bridging liquid on spherical agglomeration were studied. The agglomerates were subjected to various physicochemical evaluations such as practical yield, drug content, particle size, loss on drying, porosity, IR spectroscopy, differential scanning calorimetry, X-ray diffraction studies, relative crystallinity, scanning electron microscopy, micromeritic properties, solubility and dissolution studies. The agglomerates showed improved micromeritic properties as well as dissolution behaviour in comparison to conventional drug crystals. The optimized agglomerates (F-9) showed good sphericity as well as high drug release, and hence they were compressed into tablets by direct compression. The tablets were found within the limits with respect to various physicochemical parameters. The dissolution rate of prepared tablets was better than that of marketed tablet and pure drug. The optimized agglomerates and tablet formulations were found to be stable for 6 months under accelerated conditions. The in vivo studies (preclinical pharmacokinetics, pharmacodynamics and toxicity studies, and clinical pharmacokinetics) of optimized agglomerates were carried out. The results of preclinical studies revealed that the agglomerates provided improved pharmacodynamic and pharmacokinetic profiles of drug besides being nontoxic. The results of pharmacokinetic studies of optimized tablet in human subjects indicated improved pharmacokinetic parameters of drug in comparison with that of marketed tablet.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f1e9bc5bccf39c8c38c11879264d0a40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868011,"asset_id":4426614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868011/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426614; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426610/Characterization_of_Different_Crystal_Forms_of_Iboprofen_Tinidazole_and_Lorazepan"><img alt="Research paper thumbnail of Characterization of Different Crystal Forms of Iboprofen, Tinidazole and Lorazepan" class="work-thumbnail" src="https://attachments.academia-assets.com/49868001/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426610/Characterization_of_Different_Crystal_Forms_of_Iboprofen_Tinidazole_and_Lorazepan">Characterization of Different Crystal Forms of Iboprofen, Tinidazole and Lorazepan</a></div><div class="wp-workCard_item"><span>Drug Development and Industrial Pharmacy</span><span>, 1990</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">MalA is an -glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">MalA is an -glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting -glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli and crystallized in four different crystal forms. Microseeding was essential for the formation of good-quality crystals of forms 2 and 4. For three of the crystal forms (2, 3 and 4) full data sets could be collected. The most suitable crystals for structure determination are the monoclinic form 4 crystals, belonging to space group P2 1 , from which data sets extending to 2.5 Å resolution have been collected. Self-rotation functions calculated for this form and for the orthorhombic (P2 1 2 1 2 1 ) form 2 indicate the presence of six molecules in the asymmetric unit related by 32 symmetry.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c020655bb05e2ef0255f6dde552cfe5f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868001,"asset_id":4426610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868001/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426610; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426609"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426609/Niosome_Encapsulated_of_Vincristine_Sulfate_Improved_Anticancer_Activity_with_Reduced_Toxicity_in_Mice"><img alt="Research paper thumbnail of Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/49868007/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426609/Niosome_Encapsulated_of_Vincristine_Sulfate_Improved_Anticancer_Activity_with_Reduced_Toxicity_in_Mice">Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice</a></div><div class="wp-workCard_item"><span>Journal of Drug Targeting</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nonionic surfactant vesicles (niosomes) are promising drug carriers for anticancer drugs. Niosome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nonionic surfactant vesicles (niosomes) are promising drug carriers for anticancer drugs. Niosome encapsulated vincristine sulfate prepared by transmembrane pH gradient drug uptake process (remote loading method) was evaluated for toxicity and antitumour activity after administration to tumour bearing mice. The toxicity of vincristine sulfate was reduced after niosome encapsulation and anticancer activity improved, which may be due to better delivery of vincristine at the tumour site.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d660768ccaacbf56288c76cc18b8cda6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868007,"asset_id":4426609,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868007/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426609"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426609"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426609; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma"><img alt="Research paper thumbnail of High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma">High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma</a></div><div class="wp-workCard_item"><span>Analytical Biochemistry</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426570]").text(description); $(".js-view-count[data-work-id=4426570]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426570; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426570']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426570,"title":"High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma","internal_url":"https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426569"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography"><img alt="Research paper thumbnail of Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography" class="work-thumbnail" src="https://attachments.academia-assets.com/49868018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography">Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography</a></div><div class="wp-workCard_item"><span>Journal of Chromatography B: Biomedical Sciences and Applications</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A high-performance liquid chromatography (HPLC) method for the determination of acetaldehyde in f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A high-performance liquid chromatography (HPLC) method for the determination of acetaldehyde in fuel ethanol was developed. Acetaldehyde was derivatized with 0.900 mL 2,4-dinitrophenylhydrazine (DNPHi) reagent and 50 lL phosphoric acid 1 mol L À1 at a controlled room temperature of 15°C for 20 min. The separation of acetaldehyde-DNPH (ADNPH) was carried out on a Shimadzu Shim-pack C 18 column, using methanol/LiCl (aq) 1.0 mM (80/20, v/v) as a mobile phase under isocratic elution and UV-Vis detection at 365 nm. The standard curve of ADNPH was linear in the range 3-300 mg L À1 per injection (20 lL) and the limit of detection (LOD) for acetaldehyde was 2.03 lg L À1 , with a correlation coefficient greater than 0.999 and a precision (relative standard deviation, RSD) of 5.6% (n=5). Recovery studies were performed by fortifying fuel samples with acetaldehyde at various concentrations and the results were in the range 98.7-102%, with a coefficient of variation (CV) from 0.2% to 7.2%. Several fuel samples collected from various gas stations were analyzed and the method was successfully applied to the analysis of acetaldehyde in fuel ethanol samples.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3138dfe51077939b7776b9c14cb730b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868018,"asset_id":4426569,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868018/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426569; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3138dfe51077939b7776b9c14cb730b8" } } $('.js-work-strip[data-work-id=4426569]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426569,"title":"Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography","internal_url":"https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868018/thumbnails/1.jpg","file_name":"Rapid_and_sensitive_method_for_the_deter20161025-30800-13209k9.pdf","download_url":"https://www.academia.edu/attachments/49868018/download_file","bulk_download_file_name":"Rapid_and_sensitive_method_for_determina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868018/Rapid_and_sensitive_method_for_the_deter20161025-30800-13209k9-libre.pdf?1477439737=\u0026response-content-disposition=attachment%3B+filename%3DRapid_and_sensitive_method_for_determina.pdf\u0026Expires=1740046359\u0026Signature=fNaACyD9BiF8zfHq8NFLf7UEDXqhntLocZtPMlOHcIc2OWMuQD4igoAhTklwoi~hLfCvw7lEidztZBHE5n54MOpYuw1v89EXxquEbm56dZon8v8wS~73pUO5buL8xGzY5l5khTpIeAkrEkoxr0Fn-0cPW9wzDWJNw7RhVBXAit22pGev6EgGLFgAnlzWhgtxiCQW6Pqz2JPx0Wn-H8ZK1onV-HLawcPbHducjjx0k6GBwy8FnoTybPAkzctW1eiRV-rFUXGRZ~WLynH8k0bsuKZ-VumjFNdIS97n~RG16-QQlb52GmsZW2nkvcYwifXilXZcqrHVJhuPeE97CFsNxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426568"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics"><img alt="Research paper thumbnail of A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics" class="work-thumbnail" src="https://attachments.academia-assets.com/49868047/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics">A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics</a></div><div class="wp-workCard_item"><span>Talanta</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Tobramycin, an aminoglycoside antibiotic, is a polar pharmaceutical compound which la...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Tobramycin, an aminoglycoside antibiotic, is a polar pharmaceutical compound which lacks a UV absorbing chromophore. Due to the absence of a UV absorbing chromophore and high polar nature of this antibiotic, the analysis of such compounds becomes a major challenge. Objective: To overcome these problems, a novel method for the determination aminoglycoside tobramycin was developed and validated based on reversed-phase high-performance liquid chromatography (RP-HPLC) with UV detector. Materials and Methods: An isocratic mobile phase consists of buffer 0.05 M diammonium hydrogen phosphate, pH adjusted to 10.0 using tetramethyl ammonium hydroxide. Chromatography was carried out at 25°C on a Purosphere RP-8e, 250 mm x 4.6 mm, 5mm. The detection was carried out using variable wavelength UV-Vis detector set at 210 nm. The compounds were eluted isocratically at a steady flow rate of 1.0 mL/min. Result and Discussion: Tobramycin retention time was about 9.0 min with an asymmetry factor of 1.4. A logarithmic calibration curve was obtained from 0.47 to 0.71 mg/mL (r > 0.9998). Within-day %RSD was 0.29 (n = 6, 0.60 mg/mL) and between-day %RSD was 0.54 Specificity/ selectivity experiments revealed the absence of interference from excipients, recovery from spiked samples was between 99.0-100.0 percent. Conclusions: A HPLC method based on UV detection has been developed and validated for determination of tobramycin from ophthalmic solution. The method is simple, rapid, specific, accurate (error 0.80%), precise (RSD <2.0%) and linear (r2=0.9998). The described method is suitable for routine analysis and quality control of ophthalmic solution containing tobramycin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="facece14afcb37a9e762c8d9efe6f511" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868047,"asset_id":4426568,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868047/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426568"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426568"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426568; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426568]").text(description); $(".js-view-count[data-work-id=4426568]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426568; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426568']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "facece14afcb37a9e762c8d9efe6f511" } } $('.js-work-strip[data-work-id=4426568]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426568,"title":"A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics","internal_url":"https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868047,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868047/thumbnails/1.jpg","file_name":"A_simple_and_rapid_high-performance_liqu20161025-30800-15p5gl7.pdf","download_url":"https://www.academia.edu/attachments/49868047/download_file","bulk_download_file_name":"A_simple_and_rapid_high_performance_liqu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868047/A_simple_and_rapid_high-performance_liqu20161025-30800-15p5gl7-libre.pdf?1477439726=\u0026response-content-disposition=attachment%3B+filename%3DA_simple_and_rapid_high_performance_liqu.pdf\u0026Expires=1740046359\u0026Signature=IO~3XcxAywrdsxC3YWbNzwi2RpdxihgDnTz8BkaObkhkpmJyXI4yn7O4YDarSPhA4FMccNZ4AwiojfSDBA4NEV6ug00oAe2jZWT45ozDkrbYX2a3OKBzop3ml6LUiFiNFQT0wLueKxjUYGnTxkY7LeI7N7GXLtZS9hve76D51JpZFQ8TJRV24rt-iOIbed4-JMNUDRn7jcyeWh8x~9Nul0PRZ0lOZjhzx8bgyUJEHog2uVTt1uB5P4pu2oT42rDb4YWSvqD-bv9vIm-~k-8X25tnCO9J3gnuEGYlPzRcFjnOqv4to6F9Pai71i6N~ObFyqarJ6xYWB9PGripOYDfpQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426565"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426565/Simultaneous_determination_of_pioglitazone_and_glimepiride_in_bulk_drug_and_pharmaceutical_dosage_form_by_RP_HPLC_method"><img alt="Research paper thumbnail of Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method" class="work-thumbnail" src="https://attachments.academia-assets.com/49868010/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426565/Simultaneous_determination_of_pioglitazone_and_glimepiride_in_bulk_drug_and_pharmaceutical_dosage_form_by_RP_HPLC_method">Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method</a></div><div class="wp-workCard_item"><span>Pakistan journal of pharmaceutical sciences</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation and quantification of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form. The quantification was carried out using Inertsil ODS (250 × 4.6 mm, 5µ) column and mobile phase comprised of acetonitrile and ammonium acetate (pH 4.5; 20mM) in proportion of 60:40 (v/v). The flow rate was 1.0 ml/min and the effluent was monitored at 230 nm. The retention time of pioglitazone and glimepiride were 7.0±0.1 and 10.2±0.1 min respectively. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of detection and limit of quantitation. Linearity of pioglitazone and glimepiride were in the range of 2.0 to 200.0µg/ml and 0.5-50µg/ml respectively. The percentage recoveries of both the drugs were 99.85% and 102.06% for pioglitazone and glimepiride respectively from the tablet formulation. The proposed method is suitable for simultaneous determination of pioglitazone and glimepiride in pharmaceutical dosage form and bulk drug.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="349530bb4b964dbc11df24ed69ca8ca8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868010,"asset_id":4426565,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868010/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426565"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426565"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426565; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426565]").text(description); $(".js-view-count[data-work-id=4426565]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426565; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426565']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426563/Effect_of_Lecithin_and_silymarin_on_D_galactosamine_induced_toxicity_in_isolated_hepatocytes_and_rats"><img alt="Research paper thumbnail of Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats" class="work-thumbnail" src="https://attachments.academia-assets.com/49868006/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426563/Effect_of_Lecithin_and_silymarin_on_D_galactosamine_induced_toxicity_in_isolated_hepatocytes_and_rats">Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats</a></div><div class="wp-workCard_item"><span>Indian journal of clinical biochemistry : IJCB</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induced toxicity in freshly isolated rat hepatocytes and animal models. Freshly isolated rat hepatocytes were exposed to Dgalactosamine (30 mM) along with/without lecithin (100 μg/ml) and the levels of selected liver enzymes were measured. Thirty six Wistar strain albino rats were used for the in vivo investigations. Lecithin 50 and 100 mg/kg.b.wt were administered for one week by oral route. Liver damage was induced by intra peritoneal administration of 400 mg/kg b.wt D-galactosamine. The antihepatotoxic effect of lecithin was observed in freshly isolated rat hepatocytes at concentration 100 μg/ml and was found to be similar to that of the standard silymarin used. Its in vivo hepatoprotective effect at 100 mg/kg b.wt was comparable with that of the standard silymarin at 100 mg/kg body weight. Lecithin was able to normalise the biochemical levels which were altered due to D-galactosamine intoxication in freshly isolated rat hepatocytes and also in animal models.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da5601d6287af4bb5f390f564f7a558a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868006,"asset_id":4426563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868006/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426563; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426563]").text(description); $(".js-view-count[data-work-id=4426563]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426563; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426563']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "da5601d6287af4bb5f390f564f7a558a" } } $('.js-work-strip[data-work-id=4426563]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426563,"title":"Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats","internal_url":"https://www.academia.edu/4426563/Effect_of_Lecithin_and_silymarin_on_D_galactosamine_induced_toxicity_in_isolated_hepatocytes_and_rats","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868006,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868006/thumbnails/1.jpg","file_name":"Effect_of_Lecithin_and_silymarin_on_D-ga20161025-30800-13vcxem.pdf","download_url":"https://www.academia.edu/attachments/49868006/download_file","bulk_download_file_name":"Effect_of_Lecithin_and_silymarin_on_D_ga.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868006/Effect_of_Lecithin_and_silymarin_on_D-ga20161025-30800-13vcxem-libre.pdf?1477439743=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Lecithin_and_silymarin_on_D_ga.pdf\u0026Expires=1740046359\u0026Signature=T~oL9J46nMTZiK2Qlt0~8XoQDLZgD6EqlAX3cO-i3JJRpNtHDtnthJA-glXtEyV6zGmIScRG3ejGTc1XZUcfxAuXN7RjiTEysWXmXYOIdFr7-rE-sE3YsD8tXmsHwut6Mloag7RRdvpk~KYRyf9HwK~AZdDLeGXEymCmM3hw99XI1~1Fiow5eZgobYTOIS9rivUPMFBDencU4zHQAPaF01eDo3nfT2gKMpnxoposXIKdY-LrEmhmfQF3WroImq2s2H2174~iouAq8qy~d7k0F2GjadB3MQWoGdUOYY2awlXON5XwMQuzLYT1xPXRDfdyU4RqAoG6pyIWF~jBnbH8Qw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="721584" id="papers"><div class="js-work-strip profile--work_container" data-work-id="4426632"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies"><img alt="Research paper thumbnail of Multiparticulate drug delivery system of aceclofenac: development and in vitro studies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies">Multiparticulate drug delivery system of aceclofenac: development and in vitro studies</a></div><div class="wp-workCard_item"><span>Drug development and industrial pharmacy</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve site-specific drug release. The formulated pellets were characterized for percentage yield, size distribution, surface morphology studies, drug content, and flow properties. In vitro dissolution test was used for comparison of drug release profiles of various coated pellets. The practical yield was found to be 90-95%. The particle size of enteric-coated pellets was found to be in the range of 0.59-0.71 mm. The pellets were spherical in shape and surfaces of pellets were found to be rough and showing micropores. Enteric-coated pellets showed good flow properties and in vitro dissolution profile. Dissolution tests were carried out in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the aceclofenac from formulated pellets was established to be minimum in the pH 1.2 (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5%) for a period of 2 h, and at pH 6.8, it shows the maximum release (85 +/- 5% release within 1 h) which indicates gastric resistance of the formulated pellets. The 20% wt/wt enteric-coated pellets were compared to that of marketed product (tablets), it was observed that pellets showed better release profile. The study concluded that the formulated multiparticulate dosage forms can be used as an ideal drug delivery system for the aceclofenac.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426632"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426632"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426632; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426632]").text(description); $(".js-view-count[data-work-id=4426632]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426632; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426632']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426632]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426632,"title":"Multiparticulate drug delivery system of aceclofenac: development and in vitro studies","internal_url":"https://www.academia.edu/4426632/Multiparticulate_drug_delivery_system_of_aceclofenac_development_and_in_vitro_studies","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426631"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426631/Development_of_mucoadhesive_buccal_films_for_the_treatment_of_oral_sub_mucous_fibrosis_a_preliminary_study"><img alt="Research paper thumbnail of Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study" class="work-thumbnail" src="https://attachments.academia-assets.com/49867999/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426631/Development_of_mucoadhesive_buccal_films_for_the_treatment_of_oral_sub_mucous_fibrosis_a_preliminary_study">Development of mucoadhesive buccal films for the treatment of oral sub-mucous fibrosis: a preliminary study</a></div><div class="wp-workCard_item"><span>Pharmaceutical development and technology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The objective of the present study was to develop the mucoadhesive buccal film of valdecoxib for ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The objective of the present study was to develop the mucoadhesive buccal film of valdecoxib for the treatment of oral sub mucous fibrosis, a localized buccal disease. Valdecoxib, a novel COX-2 inhibitor has been reported to be used in various osteopathic and rheumatoid conditions as oral therapy. The films were made out of chitosan and HPMC K4M as polymers. Sodium taurocholate was used as a permeation enhancer. All the formulations were examined for film thickness, swelling properties, drug content, weight variation, in vitro release studies, bioadhesive force, tensile strength, diffusion studies using pig mucosa and pharmacokinetic study in healthy male volunteers. Prepared films were thin, flexible, smooth and transparent. Bioadhesive force and tensile strength of the optimized formulation were found to be 75 ± 4 kg m −1 S −2 and more than 2.5 kg/3 cm 2 , respectively. The percent drug content was 98.5 ± 1.3%. The in vitro drug release from the selected formulation showed that about 69.34% of the drug payload was released up to 6 hours. The drug permeation through the dialysis sac and pig buccal mucosa was found to be 62.70% and 54.39%, respectively. Pharmacokinetic studies of the buccal mucoadhesive film showed that the drug was released locally at the target site of action, and a very small amount might have absorbed systemically.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bbac9ac7ecdf39d0c3e5a244968f28b7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49867999,"asset_id":4426631,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49867999/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426631"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426631; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426630"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426630/Preparation_in_vitro_characterization_pharmacokinetic_and_pharmacodynamic_evaluation_of_chitosan_based_plumbagin_microspheres_in_mice_bearing_B16F1_melanoma"><img alt="Research paper thumbnail of Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma" class="work-thumbnail" src="https://attachments.academia-assets.com/49868279/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426630/Preparation_in_vitro_characterization_pharmacokinetic_and_pharmacodynamic_evaluation_of_chitosan_based_plumbagin_microspheres_in_mice_bearing_B16F1_melanoma">Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma</a></div><div class="wp-workCard_item"><span>Drug delivery</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1650af3b3c0bbdb16565c7c57419267e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868279,"asset_id":4426630,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868279/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426630]").text(description); $(".js-view-count[data-work-id=4426630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426629/Chitosan_and_enteric_polymer_based_once_daily_sustained_release_tablets_of_aceclofenac_in_vitro_and_in_vivo_studies"><img alt="Research paper thumbnail of Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies" class="work-thumbnail" src="https://attachments.academia-assets.com/49868008/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426629/Chitosan_and_enteric_polymer_based_once_daily_sustained_release_tablets_of_aceclofenac_in_vitro_and_in_vivo_studies">Chitosan and enteric polymer based once daily sustained release tablets of aceclofenac: in vitro and in vivo studies</a></div><div class="wp-workCard_item"><span>AAPS PharmSciTech</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of this study was to develop a once daily sustained release tablet of aceclofenac usi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of this study was to develop a once daily sustained release tablet of aceclofenac using chitosan and an enteric coating polymer (hydroxypropyl methylcellulose phthalate or cellulose acetate phthalate). Overall sustained release for 24 h was achieved by preparing a double-layer tablet in which the immediate release layer was formulated for a prompt release of the drug and the sustained release layer was designed to achieve a prolonged release of drug. The preformulation studies like IR spectroscopic and differential scanning calorimetry showed the absence of drug–excipient interactions. The tablets were found within the permissible limits for various physicochemical parameters. Scanning electron microscopy was used to visualize the surface morphology of the tablets and to confirm drug release mechanisms. Good equivalence in the drug release profile was observed when drug release pattern of the tablet containing chitosan and hydroxypropyl methylcellulose phthalate (M-7) was compared with that of marketed tablet. The optimized tablets were stable at accelerated storage conditions for 6 months with respect to drug content and physical appearance. The results of pharmacokinetic studies in human volunteers showed that the optimized tablet (M-7) exhibited no difference in the in vivo drug release in comparison with marketed tablet. No significant difference between the values of pharmacokinetic parameters of M-7 and marketed tablets was observed (p > 0.05; 95% confidence intervals). However the clinical studies in large scale and, long term and extensive stability studies at different conditions are required to confirm these results.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6898c6fa8abf9b6278dc131207c1cac2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868008,"asset_id":4426629,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868008/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426629; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426626/Protective_Role_of_Catechin_on_d_Galactosamine_Induced_Hepatotoxicity_Through_a_p53_Dependent_Pathway"><img alt="Research paper thumbnail of Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/49868004/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426626/Protective_Role_of_Catechin_on_d_Galactosamine_Induced_Hepatotoxicity_Through_a_p53_Dependent_Pathway">Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway</a></div><div class="wp-workCard_item"><span>Indian journal of clinical biochemistry : IJCB</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective of this study was to obtain a better understanding of the mechanism responsible for the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity. Catechin 50 and 100 mg/kg b.wt was administered for 1 week by oral route. Liver damage was induced by intra-peritoneal administration of 400 mg/kg b.wt d-galactosamine on the last day of catechin treatment. At the end of treatment all animals were killed and liver enzyme levels were estimated. Dissected hepatic samples were used for histopathology, RNA isolation, expression studies of Bax, Bcl-2 and p53 mRNA levels and mitochondrial membrane potential studies. We found that increases in the liver enzyme activity and decrease in antioxidant enzyme activity by d-GalN were significantly restricted by oral pretreatment with catechin. Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1966ef341a259eabe62cc1b053fd20bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868004,"asset_id":4426626,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868004/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426626; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426622/Size_controlled_synthesis_of_biocompatible_gold_nanoparticles_and_their_activity_in_the_oxidation_of_NADH"><img alt="Research paper thumbnail of Size controlled synthesis of biocompatible gold nanoparticles and their activity in the oxidation of NADH" class="work-thumbnail" src="https://attachments.academia-assets.com/49868002/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426622/Size_controlled_synthesis_of_biocompatible_gold_nanoparticles_and_their_activity_in_the_oxidation_of_NADH">Size controlled synthesis of biocompatible gold nanoparticles and their activity in the oxidation of NADH</a></div><div class="wp-workCard_item"><span>Nanotechnology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Size and shape controlled synthesis remains a major bottleneck in the research on nanoparticles e...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Size and shape controlled synthesis remains a major bottleneck in the research on nanoparticles even after the development of different methods for their preparation. By tuning the size and shape of a nanoparticle, the intrinsic properties of the nanoparticle can be controlled leading tremendous potential applications in different fields of science and technology. We describe a facile route for the one pot synthesis of gold nanoparticles in water using monosodium glutamate as the reducing and stabilizing agent in the absence of seed particles. The particle diameter can be easily controlled by varying the pH of the reaction medium. Nanoparticles were characterized using scanning electron microscopy, UV-vis absorption spectroscopy, cyclic voltammetry, and dynamic light scattering. Zeta potential measurements were made to compare the stability of the different nanoparticles. The results suggest that lower pH favours a nucleation rate giving rise to smaller particles and higher pH favours a growth rate leading to the formation of larger particles. The synthesized nanoparticles are found to be stable and biocompatible. The nanoparticles synthesized at high pH exhibited a good electrocatalytic activity towards oxidation of nicotinamide adenine dinucleotide (NADH).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db91ddf386fe6cb2679c659f29fc037f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868002,"asset_id":4426622,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868002/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426622"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426622"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426622; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426619"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426619/Solid_dispersions_a_review"><img alt="Research paper thumbnail of Solid dispersions: a review" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426619/Solid_dispersions_a_review">Solid dispersions: a review</a></div><div class="wp-workCard_item"><span>Pakistan journal of pharmaceutical sciences</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Solid dispersions have attracted considerable interest as an efficient means of improving the dis...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions and recent revival has been considered.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426619"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426619]").text(description); $(".js-view-count[data-work-id=4426619]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426619']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426619]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426619,"title":"Solid dispersions: a review","internal_url":"https://www.academia.edu/4426619/Solid_dispersions_a_review","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation"><img alt="Research paper thumbnail of A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation" class="work-thumbnail" src="https://attachments.academia-assets.com/49868041/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation">A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation</a></div><div class="wp-workCard_item"><span>European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Catechin is a known hepatoprotective and anticancer agent but has limited bioavailability. Its ap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Catechin is a known hepatoprotective and anticancer agent but has limited bioavailability. Its apoptotic signaling pathway in human hepatocellular carcinoma is vaguely explored. Thus, this study was designed to explore cytotoxicity by MTT assay, induction of apoptosis via DNA fragmentation, nuclear staining, bivariate flow cytometric analysis using annexin V-FITC and propidium iodide, cell cycle analysis and apoptotic markers by RT-PCR and western blotting in HepG2 cells. To increase the bioavailability and selectivity to cancer cells, various liposomes of catechin viz., conventional, charged and PEGylated forms were prepared by film hydration method and evaluated for cytotoxicity in vitro in HepG2 cells and in in vivo in EAC-induced liquid tumor model. Catechin and catechin liposomes inhibited the growth of HepG2 cell lines at concentrations 100-200 lg mL À1 depending on the length of exposure. It induced apoptosis and inhibited G 2 /M phase in cell cycle analysis. Catechin downregulated Bcl-2, initiated the release of cytochrome c into the cytosol and upregulated Bax, caspase-3,-9 and p53 in the HepG2 cells. Catechin and its liposomal formulation, at a dose of 200 mg/kg body weight was found to be significantly (p < 0.05) effective in inhibiting percentage increase in body weight and enhancing the mean survival time. Deviated hematological parameters, antioxidant parameters (superoxide dismutase, catalase and lipid peroxidation) and LFT in tumor bearing mice were found to be significantly (p < 0.05) restored towards normal after treatment with catechin and its liposomes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3d5d78b4ee8048d6dc98502123e76437" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868041,"asset_id":4426618,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868041/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426618]").text(description); $(".js-view-count[data-work-id=4426618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3d5d78b4ee8048d6dc98502123e76437" } } $('.js-work-strip[data-work-id=4426618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426618,"title":"A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation","internal_url":"https://www.academia.edu/4426618/A_study_on_the_role_of_catechin_in_suppression_of_HepG2_proliferation_via_caspase_dependent_pathway_and_enhancement_of_itsin_vitro_and_in_vivo_cytotoxic_potential_through_liposomal_formulation","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868041,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868041/thumbnails/1.jpg","file_name":"A_study_on_the_role_of_-catechin_in_su20161025-30797-t5f8l1.pdf","download_url":"https://www.academia.edu/attachments/49868041/download_file","bulk_download_file_name":"A_study_on_the_role_of_catechin_in_suppr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868041/A_study_on_the_role_of_-catechin_in_su20161025-30797-t5f8l1-libre.pdf?1477439731=\u0026response-content-disposition=attachment%3B+filename%3DA_study_on_the_role_of_catechin_in_suppr.pdf\u0026Expires=1740046359\u0026Signature=AqWK92xgpvGJ6WxyTuLGOrL1dWWWB03zHQIjWf1SJKJPOTlF-K7gEWhyQOZeTmpTghoI57Ph8VviZGHuzPt-bI~rHrzwN1HuOsM7ywQV9bpe~JnPQUb9kZZHW-fo8BiYXDWTmC5HoJJcTZUGKy0FVkBZVUvNjK~BWlH0XWNZAsFcasXeeL3E5Ui-H4BEVbpV5vynR~4O0uC6TtRG9w-VLgFKzfjNYhn9APoowP3XBh11b7NtpcQ-Nm2cjI~cdON1ia~g8CQbQMnQkJO2FOhksAJF7bNcA80XvTfFQt6EGlRmB02BbJXP9QnvtYeAdxJZZBndF3RVILy2eoefixyexg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426617"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system"><img alt="Research paper thumbnail of Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system" class="work-thumbnail" src="https://attachments.academia-assets.com/49868000/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system">Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system</a></div><div class="wp-workCard_item"><span>Journal of controlled release : official journal of the Controlled Release Society</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulations with constant/programmable delivery rates make it possible to deliver drug at definite time or controlled rate in chronopharmacokinetic studies. The prepared system contained swellable polymer (L-hydroxypropyl cellulose (L-HPC), xanthan gum, polyethylene oxide or sodium alginate) together with drug tablet and erodible tablet (L-HPC or guar gum) in a pre-coated capsule. Various formulation factors were investigated through series of tests, in vitro dissolution and ex vivo continuous dissolution-absorption studies. We found that the type, amount of polymers and erodible tablet influenced the drug release. The formulation containing 200 mg sodium alginate and erodible tablet (150 mg) containing 50% guar gum and 46% lactose showed 5-6 h lag time and 10 ± 2.1% drug release in initial 6 h following rapid release (99 ± 1.7% release in 12 h) of drug was observed. The continuous dissolutionabsorption study conducted using everted rat intestinal segment indicated delay in absorption of drug. Thus this approach can provide a useful means for timed release of valsartan and may be helpful for patients with morning surge.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="179609b32ad26368653f251753fb82ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868000,"asset_id":4426617,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868000/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426617"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426617"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426617; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426617]").text(description); $(".js-view-count[data-work-id=4426617]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426617; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426617']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "179609b32ad26368653f251753fb82ab" } } $('.js-work-strip[data-work-id=4426617]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426617,"title":"Chronotherapeutic drug delivery for early morning surge in blood pressure: a programmable delivery system","internal_url":"https://www.academia.edu/4426617/Chronotherapeutic_drug_delivery_for_early_morning_surge_in_blood_pressure_a_programmable_delivery_system","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868000,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868000/thumbnails/1.jpg","file_name":"Chronotherapeutic_drug_delivery_for_earl20161025-30797-i5lvf7.pdf","download_url":"https://www.academia.edu/attachments/49868000/download_file","bulk_download_file_name":"Chronotherapeutic_drug_delivery_for_earl.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868000/Chronotherapeutic_drug_delivery_for_earl20161025-30797-i5lvf7-libre.pdf?1477439746=\u0026response-content-disposition=attachment%3B+filename%3DChronotherapeutic_drug_delivery_for_earl.pdf\u0026Expires=1740046359\u0026Signature=D4yXeEewbXeXgtoF71sgIEm7FAggiuEGnwZ7Muwya8yj5Qsx-xPt7stmauV78ddIWhssePAawL-NN-EMuAHfl8Y44PEYC4cj3RzbeR8a1WruHiHvRCbgPTQNneM6mD26FV61bBWTWhm2cbN4bKADlln7kSdRX9h3ARzMqWdp5EwJt~VBf6F2XYX0S-ahoXEusqLIe7NZwrjQsKIpHsd0tCYD4WakB4fMVvlWT7vP44dFVD342zBg2Ve3P8WlJz~cSBEVMhMint1FTFgETOh4FCczCADrIxg6fGztKVH-y-fNh1Enl1eUtCokHxRuSZH0EI8Rib0lASjd77zigvHciQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426616"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies"><img alt="Research paper thumbnail of Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies" class="work-thumbnail" src="https://attachments.academia-assets.com/49868005/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies">Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies</a></div><div class="wp-workCard_item"><span>Integrative cancer therapies</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study aimed at evaluating the anticancer and radiosensitizing potential of juglone ag...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study aimed at evaluating the anticancer and radiosensitizing potential of juglone against a chemoresistant and radioresistant tumor (B16F1 melanoma) growing on C57BL/6J mice. Volume doubling time, growth delay, and median survival were used to assess the in vivo anticancer and radiosensitizing potential of juglone. In vitro radiosensitizing potential of juglone was studied using clonogenic, comet, and reactive oxygen species induction assays. Treatment of tumor-bearing mice with sublethal doses of juglone caused a dose-dependent inhibition of tumor growth as evident from the growth delay and median survival values. Comet assay using tumor tissue and blood showed differential toxicity of juglone, where higher levels of DNA damage was seen in tumor tissue compared with blood cells. Pretreatment of tumor-bearing mice with optimum dose of juglone before radiation resulted in significant tumor growth inhibition compared with radiation alone. From the clonogenic assay, the authors observed a sensitization enhancement ratio of 1.37 for the combination treatment compared with radiation alone. Furthermore, comet assay studies revealed the potential of juglone to enhance the radiation-induced DNA damage and cause a delay in its repair. Juglone pretreatment before radiation also resulted in a significant elevation in the intracellular reactive oxygen species levels compared with radiation alone. In conclusion, the results of this study show the potential of juglone to inhibit the growth of melanoma in vivo. The study also revealed the potential of juglone to augment the radiation-induced cell death of melanoma cells, which may be attributed to oxidative stress-mediated DNA damage and its delayed repair.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d357c55d350fb85b004591eba5b58e4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868005,"asset_id":4426616,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868005/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426616"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426616"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426616; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426616]").text(description); $(".js-view-count[data-work-id=4426616]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426616; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426616']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1d357c55d350fb85b004591eba5b58e4" } } $('.js-work-strip[data-work-id=4426616]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426616,"title":"Tumor growth inhibitory effect of juglone and its radiation sensitizing potential: in vivo and in vitro studies","internal_url":"https://www.academia.edu/4426616/Tumor_growth_inhibitory_effect_of_juglone_and_its_radiation_sensitizing_potential_in_vivo_and_in_vitro_studies","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868005,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868005/thumbnails/1.jpg","file_name":"Tumor_growth_inhibitory_effect_of_juglon20161025-30797-1lrd4du.pdf","download_url":"https://www.academia.edu/attachments/49868005/download_file","bulk_download_file_name":"Tumor_growth_inhibitory_effect_of_juglon.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868005/Tumor_growth_inhibitory_effect_of_juglon20161025-30797-1lrd4du-libre.pdf?1477439745=\u0026response-content-disposition=attachment%3B+filename%3DTumor_growth_inhibitory_effect_of_juglon.pdf\u0026Expires=1740046359\u0026Signature=cRzdaVQdt5RXk0Xm-Aha1xBvJXDcbiqbIc16rfC9gT8HlT~vSw6yHorrKpW-mG7tuK7JrOKJMWFuJOH~wK0rlpOa6F3OjQPfBedGuoRhiyC1lMEG6zs56oteEXFg-gExp8iSjQjenZXG3a81yqxwgKNezVjBI91hEdJRoMpivSUmVP50H6piwtjPcU8boUw4YG3503rCXF6C~csFP4dujukOnJfXAQ1Kdb9XkqkVpc87br-8l8NTHvncDrv0LxO~mzxaFB4IhstChOTnmbY3jHaDRaS6A~8ZF04VoIgdzGrEJT4yY1uay2y9oJa0P-jH-PrpgbfUiGIv9r0E0CDqXQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin"><img alt="Research paper thumbnail of Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin" class="work-thumbnail" src="https://attachments.academia-assets.com/49868003/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin">Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin</a></div><div class="wp-workCard_item"><span>Biopharmaceutics & drug disposition</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most known interactions between herbal extracts and drugs involve the inhibition of drug-metaboli...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most known interactions between herbal extracts and drugs involve the inhibition of drug-metabolizing enzymes, but little is yet known about the possible role of transporters in these interactions. In order to evaluate the effect of one of such prominent flavonoids, morin, on P-glycoprotein related efflux carriers, measurements of transport characteristics through Ussing chambers, in situ perfusion and in vivo drug absorption studies were performed with the transported, yet not metabolized model compound talinolol.This study investigated the effects of orally administered morin (1.0, 2.5 and 5.0 mg kg−1), on the pharmacokinetics of orally (10 mg kg−1) and intravenously (1.0 mg kg−1) administered talinolol in rats. In the presence of morin, the pharmacokinetic parameters of talinolol were significantly altered in the oral group but not in the intravenous group. The presence of 2.5 and 5.0 mg kg−1 of morin significantly increased (1.8–2.0 fold, p<0.01) the area under the plasma concentration–time curve and the peak plasma concentration (2.3–3.0 fold, p<0.01) of orally administered talinolol. The absolute bioavailability (F %) of talinolol in the rats pretreated with morin was significantly higher (89.09–98.29%, p<0.01) than the control (52.14%). Talinolol demonstrated asymmetric transport across rat ileum with significantly greater basolateral-to-apical (B–A) permeability than that in the apical-to-basolateral (A–B) direction. The addition of morin resulted in a concentration dependent effect, especially on the secretory transport of talinolol.The present study demonstrates that morin bears the ability to interfere with secretory intestinal transport processes. This might be due to an interaction with P-glycoprotein. Copyright © 2010 John Wiley & Sons, Ltd.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6b87de30e6039fc2cef876b9a3743a36" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868003,"asset_id":4426615,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868003/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426615]").text(description); $(".js-view-count[data-work-id=4426615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6b87de30e6039fc2cef876b9a3743a36" } } $('.js-work-strip[data-work-id=4426615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426615,"title":"Pre-clinical evidence of enhanced oral bioavailability of the P-glycoprotein substrate talinolol in combination with morin","internal_url":"https://www.academia.edu/4426615/Pre_clinical_evidence_of_enhanced_oral_bioavailability_of_the_P_glycoprotein_substrate_talinolol_in_combination_with_morin","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868003,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868003/thumbnails/1.jpg","file_name":"Pre-clinical_evidence_of_enhanced_oral_b20161025-30800-uhgdbb.pdf","download_url":"https://www.academia.edu/attachments/49868003/download_file","bulk_download_file_name":"Pre_clinical_evidence_of_enhanced_oral_b.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868003/Pre-clinical_evidence_of_enhanced_oral_b20161025-30800-uhgdbb-libre.pdf?1477439745=\u0026response-content-disposition=attachment%3B+filename%3DPre_clinical_evidence_of_enhanced_oral_b.pdf\u0026Expires=1740046359\u0026Signature=SVYFUXp-1Pucj68Ky-Cr~Lfgpq1qth0BCf2xGLSdYSG5hzEhp4URniogawoag6g0-6ibozsEyoZEM8XkniQ0Vb2p7AVcVRORK4O2W2VccNG8DnJclhdnRxxE8~fA6t95lqR4iJCDNHnoibu0PpvGVKL3EUA3kBs8TmgeIld3Jo7snTA5dMRCbWSBsUqSRWWU~iFSYO9r7yZt~0l~6Zo76f1jupo1rS-NX~Aia9sJ4bGsL~L6kd4iVXMxEo5CrV9VBFCq53ctcPbmOKkpABsOp7mxzKWSibSc~qBs0g4DBv~g8RVuJ95fTYTdzgFqPaZuEjyGu9ueZtH2VysW1nG9YA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426614"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426614/Preparation_and_in_vitro_preclinical_and_clinical_studies_of_aceclofenac_spherical_agglomerates"><img alt="Research paper thumbnail of Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates" class="work-thumbnail" src="https://attachments.academia-assets.com/49868011/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426614/Preparation_and_in_vitro_preclinical_and_clinical_studies_of_aceclofenac_spherical_agglomerates">Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates</a></div><div class="wp-workCard_item"><span>European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aceclofenac agglomerates were prepared by spherical crystallization technique using a three solve...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aceclofenac agglomerates were prepared by spherical crystallization technique using a three solvent system comprising acetone: dichloromethane (DCM): water (bridging liquid, good solvent and bad solvent, respectively). Hydroxypropyl methylcellulose-50 cps (HPMC) in different concentrations was used as hydrophilic polymer. The effect of speed of rotation and amount of bridging liquid on spherical agglomeration were studied. The agglomerates were subjected to various physicochemical evaluations such as practical yield, drug content, particle size, loss on drying, porosity, IR spectroscopy, differential scanning calorimetry, X-ray diffraction studies, relative crystallinity, scanning electron microscopy, micromeritic properties, solubility and dissolution studies. The agglomerates showed improved micromeritic properties as well as dissolution behaviour in comparison to conventional drug crystals. The optimized agglomerates (F-9) showed good sphericity as well as high drug release, and hence they were compressed into tablets by direct compression. The tablets were found within the limits with respect to various physicochemical parameters. The dissolution rate of prepared tablets was better than that of marketed tablet and pure drug. The optimized agglomerates and tablet formulations were found to be stable for 6 months under accelerated conditions. The in vivo studies (preclinical pharmacokinetics, pharmacodynamics and toxicity studies, and clinical pharmacokinetics) of optimized agglomerates were carried out. The results of preclinical studies revealed that the agglomerates provided improved pharmacodynamic and pharmacokinetic profiles of drug besides being nontoxic. The results of pharmacokinetic studies of optimized tablet in human subjects indicated improved pharmacokinetic parameters of drug in comparison with that of marketed tablet.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f1e9bc5bccf39c8c38c11879264d0a40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868011,"asset_id":4426614,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868011/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426614"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426614"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426614; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426610"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426610/Characterization_of_Different_Crystal_Forms_of_Iboprofen_Tinidazole_and_Lorazepan"><img alt="Research paper thumbnail of Characterization of Different Crystal Forms of Iboprofen, Tinidazole and Lorazepan" class="work-thumbnail" src="https://attachments.academia-assets.com/49868001/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426610/Characterization_of_Different_Crystal_Forms_of_Iboprofen_Tinidazole_and_Lorazepan">Characterization of Different Crystal Forms of Iboprofen, Tinidazole and Lorazepan</a></div><div class="wp-workCard_item"><span>Drug Development and Industrial Pharmacy</span><span>, 1990</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">MalA is an -glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">MalA is an -glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting -glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli and crystallized in four different crystal forms. Microseeding was essential for the formation of good-quality crystals of forms 2 and 4. For three of the crystal forms (2, 3 and 4) full data sets could be collected. The most suitable crystals for structure determination are the monoclinic form 4 crystals, belonging to space group P2 1 , from which data sets extending to 2.5 Å resolution have been collected. Self-rotation functions calculated for this form and for the orthorhombic (P2 1 2 1 2 1 ) form 2 indicate the presence of six molecules in the asymmetric unit related by 32 symmetry.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c020655bb05e2ef0255f6dde552cfe5f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868001,"asset_id":4426610,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868001/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426610"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426610"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426610; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426609"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426609/Niosome_Encapsulated_of_Vincristine_Sulfate_Improved_Anticancer_Activity_with_Reduced_Toxicity_in_Mice"><img alt="Research paper thumbnail of Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/49868007/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426609/Niosome_Encapsulated_of_Vincristine_Sulfate_Improved_Anticancer_Activity_with_Reduced_Toxicity_in_Mice">Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice</a></div><div class="wp-workCard_item"><span>Journal of Drug Targeting</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nonionic surfactant vesicles (niosomes) are promising drug carriers for anticancer drugs. Niosome...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nonionic surfactant vesicles (niosomes) are promising drug carriers for anticancer drugs. Niosome encapsulated vincristine sulfate prepared by transmembrane pH gradient drug uptake process (remote loading method) was evaluated for toxicity and antitumour activity after administration to tumour bearing mice. The toxicity of vincristine sulfate was reduced after niosome encapsulation and anticancer activity improved, which may be due to better delivery of vincristine at the tumour site.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d660768ccaacbf56288c76cc18b8cda6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868007,"asset_id":4426609,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868007/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426609"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426609"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426609; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma"><img alt="Research paper thumbnail of High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma">High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma</a></div><div class="wp-workCard_item"><span>Analytical Biochemistry</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426570"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426570; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426570]").text(description); $(".js-view-count[data-work-id=4426570]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426570; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426570']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=4426570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426570,"title":"High-Performance Liquid Chromatographic Determination of Insulin in Rat and Human Plasma","internal_url":"https://www.academia.edu/4426570/High_Performance_Liquid_Chromatographic_Determination_of_Insulin_in_Rat_and_Human_Plasma","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426569"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography"><img alt="Research paper thumbnail of Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography" class="work-thumbnail" src="https://attachments.academia-assets.com/49868018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography">Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography</a></div><div class="wp-workCard_item"><span>Journal of Chromatography B: Biomedical Sciences and Applications</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A high-performance liquid chromatography (HPLC) method for the determination of acetaldehyde in f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A high-performance liquid chromatography (HPLC) method for the determination of acetaldehyde in fuel ethanol was developed. Acetaldehyde was derivatized with 0.900 mL 2,4-dinitrophenylhydrazine (DNPHi) reagent and 50 lL phosphoric acid 1 mol L À1 at a controlled room temperature of 15°C for 20 min. The separation of acetaldehyde-DNPH (ADNPH) was carried out on a Shimadzu Shim-pack C 18 column, using methanol/LiCl (aq) 1.0 mM (80/20, v/v) as a mobile phase under isocratic elution and UV-Vis detection at 365 nm. The standard curve of ADNPH was linear in the range 3-300 mg L À1 per injection (20 lL) and the limit of detection (LOD) for acetaldehyde was 2.03 lg L À1 , with a correlation coefficient greater than 0.999 and a precision (relative standard deviation, RSD) of 5.6% (n=5). Recovery studies were performed by fortifying fuel samples with acetaldehyde at various concentrations and the results were in the range 98.7-102%, with a coefficient of variation (CV) from 0.2% to 7.2%. Several fuel samples collected from various gas stations were analyzed and the method was successfully applied to the analysis of acetaldehyde in fuel ethanol samples.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3138dfe51077939b7776b9c14cb730b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868018,"asset_id":4426569,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868018/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426569; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3138dfe51077939b7776b9c14cb730b8" } } $('.js-work-strip[data-work-id=4426569]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426569,"title":"Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography","internal_url":"https://www.academia.edu/4426569/Rapid_and_sensitive_method_for_determination_of_nimesulide_in_human_plasma_by_high_performance_liquid_chromatography","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868018/thumbnails/1.jpg","file_name":"Rapid_and_sensitive_method_for_the_deter20161025-30800-13209k9.pdf","download_url":"https://www.academia.edu/attachments/49868018/download_file","bulk_download_file_name":"Rapid_and_sensitive_method_for_determina.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868018/Rapid_and_sensitive_method_for_the_deter20161025-30800-13209k9-libre.pdf?1477439737=\u0026response-content-disposition=attachment%3B+filename%3DRapid_and_sensitive_method_for_determina.pdf\u0026Expires=1740046359\u0026Signature=fNaACyD9BiF8zfHq8NFLf7UEDXqhntLocZtPMlOHcIc2OWMuQD4igoAhTklwoi~hLfCvw7lEidztZBHE5n54MOpYuw1v89EXxquEbm56dZon8v8wS~73pUO5buL8xGzY5l5khTpIeAkrEkoxr0Fn-0cPW9wzDWJNw7RhVBXAit22pGev6EgGLFgAnlzWhgtxiCQW6Pqz2JPx0Wn-H8ZK1onV-HLawcPbHducjjx0k6GBwy8FnoTybPAkzctW1eiRV-rFUXGRZ~WLynH8k0bsuKZ-VumjFNdIS97n~RG16-QQlb52GmsZW2nkvcYwifXilXZcqrHVJhuPeE97CFsNxA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426568"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics"><img alt="Research paper thumbnail of A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics" class="work-thumbnail" src="https://attachments.academia-assets.com/49868047/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics">A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics</a></div><div class="wp-workCard_item"><span>Talanta</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Tobramycin, an aminoglycoside antibiotic, is a polar pharmaceutical compound which la...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Tobramycin, an aminoglycoside antibiotic, is a polar pharmaceutical compound which lacks a UV absorbing chromophore. Due to the absence of a UV absorbing chromophore and high polar nature of this antibiotic, the analysis of such compounds becomes a major challenge. Objective: To overcome these problems, a novel method for the determination aminoglycoside tobramycin was developed and validated based on reversed-phase high-performance liquid chromatography (RP-HPLC) with UV detector. Materials and Methods: An isocratic mobile phase consists of buffer 0.05 M diammonium hydrogen phosphate, pH adjusted to 10.0 using tetramethyl ammonium hydroxide. Chromatography was carried out at 25°C on a Purosphere RP-8e, 250 mm x 4.6 mm, 5mm. The detection was carried out using variable wavelength UV-Vis detector set at 210 nm. The compounds were eluted isocratically at a steady flow rate of 1.0 mL/min. Result and Discussion: Tobramycin retention time was about 9.0 min with an asymmetry factor of 1.4. A logarithmic calibration curve was obtained from 0.47 to 0.71 mg/mL (r > 0.9998). Within-day %RSD was 0.29 (n = 6, 0.60 mg/mL) and between-day %RSD was 0.54 Specificity/ selectivity experiments revealed the absence of interference from excipients, recovery from spiked samples was between 99.0-100.0 percent. Conclusions: A HPLC method based on UV detection has been developed and validated for determination of tobramycin from ophthalmic solution. The method is simple, rapid, specific, accurate (error 0.80%), precise (RSD <2.0%) and linear (r2=0.9998). The described method is suitable for routine analysis and quality control of ophthalmic solution containing tobramycin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="facece14afcb37a9e762c8d9efe6f511" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868047,"asset_id":4426568,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868047/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426568"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426568"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426568; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "facece14afcb37a9e762c8d9efe6f511" } } $('.js-work-strip[data-work-id=4426568]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":4426568,"title":"A simple and rapid high performance liquid chromatographic method with fluorescence detection for the estimation of fexofenadine in rat plasma—Application to preclinical pharmacokinetics","internal_url":"https://www.academia.edu/4426568/A_simple_and_rapid_high_performance_liquid_chromatographic_method_with_fluorescence_detection_for_the_estimation_of_fexofenadine_in_rat_plasma_Application_to_preclinical_pharmacokinetics","owner_id":5436993,"coauthors_can_edit":true,"owner":{"id":5436993,"first_name":"Nayanabhirama","middle_initials":null,"last_name":"Udupa","page_name":"NayanabhiramaUdupa","domain_name":"manipal","created_at":"2013-09-06T19:28:20.677-07:00","display_name":"Nayanabhirama Udupa","url":"https://manipal.academia.edu/NayanabhiramaUdupa"},"attachments":[{"id":49868047,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/49868047/thumbnails/1.jpg","file_name":"A_simple_and_rapid_high-performance_liqu20161025-30800-15p5gl7.pdf","download_url":"https://www.academia.edu/attachments/49868047/download_file","bulk_download_file_name":"A_simple_and_rapid_high_performance_liqu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/49868047/A_simple_and_rapid_high-performance_liqu20161025-30800-15p5gl7-libre.pdf?1477439726=\u0026response-content-disposition=attachment%3B+filename%3DA_simple_and_rapid_high_performance_liqu.pdf\u0026Expires=1740046359\u0026Signature=IO~3XcxAywrdsxC3YWbNzwi2RpdxihgDnTz8BkaObkhkpmJyXI4yn7O4YDarSPhA4FMccNZ4AwiojfSDBA4NEV6ug00oAe2jZWT45ozDkrbYX2a3OKBzop3ml6LUiFiNFQT0wLueKxjUYGnTxkY7LeI7N7GXLtZS9hve76D51JpZFQ8TJRV24rt-iOIbed4-JMNUDRn7jcyeWh8x~9Nul0PRZ0lOZjhzx8bgyUJEHog2uVTt1uB5P4pu2oT42rDb4YWSvqD-bv9vIm-~k-8X25tnCO9J3gnuEGYlPzRcFjnOqv4to6F9Pai71i6N~ObFyqarJ6xYWB9PGripOYDfpQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426565"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426565/Simultaneous_determination_of_pioglitazone_and_glimepiride_in_bulk_drug_and_pharmaceutical_dosage_form_by_RP_HPLC_method"><img alt="Research paper thumbnail of Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method" class="work-thumbnail" src="https://attachments.academia-assets.com/49868010/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426565/Simultaneous_determination_of_pioglitazone_and_glimepiride_in_bulk_drug_and_pharmaceutical_dosage_form_by_RP_HPLC_method">Simultaneous determination of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form by RP-HPLC method</a></div><div class="wp-workCard_item"><span>Pakistan journal of pharmaceutical sciences</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A simple, fast, and precise reverse phase, isocratic HPLC method was developed for the separation and quantification of pioglitazone and glimepiride in bulk drug and pharmaceutical dosage form. The quantification was carried out using Inertsil ODS (250 × 4.6 mm, 5µ) column and mobile phase comprised of acetonitrile and ammonium acetate (pH 4.5; 20mM) in proportion of 60:40 (v/v). The flow rate was 1.0 ml/min and the effluent was monitored at 230 nm. The retention time of pioglitazone and glimepiride were 7.0±0.1 and 10.2±0.1 min respectively. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of detection and limit of quantitation. Linearity of pioglitazone and glimepiride were in the range of 2.0 to 200.0µg/ml and 0.5-50µg/ml respectively. The percentage recoveries of both the drugs were 99.85% and 102.06% for pioglitazone and glimepiride respectively from the tablet formulation. The proposed method is suitable for simultaneous determination of pioglitazone and glimepiride in pharmaceutical dosage form and bulk drug.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="349530bb4b964dbc11df24ed69ca8ca8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868010,"asset_id":4426565,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868010/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426565"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426565"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426565; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4426565]").text(description); $(".js-view-count[data-work-id=4426565]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4426565; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='4426565']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4426563"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4426563/Effect_of_Lecithin_and_silymarin_on_D_galactosamine_induced_toxicity_in_isolated_hepatocytes_and_rats"><img alt="Research paper thumbnail of Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats" class="work-thumbnail" src="https://attachments.academia-assets.com/49868006/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4426563/Effect_of_Lecithin_and_silymarin_on_D_galactosamine_induced_toxicity_in_isolated_hepatocytes_and_rats">Effect of Lecithin and silymarin on D-galactosamine induced toxicity in isolated hepatocytes and rats</a></div><div class="wp-workCard_item"><span>Indian journal of clinical biochemistry : IJCB</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induced toxicity in freshly isolated rat hepatocytes and animal models. Freshly isolated rat hepatocytes were exposed to Dgalactosamine (30 mM) along with/without lecithin (100 μg/ml) and the levels of selected liver enzymes were measured. Thirty six Wistar strain albino rats were used for the in vivo investigations. Lecithin 50 and 100 mg/kg.b.wt were administered for one week by oral route. Liver damage was induced by intra peritoneal administration of 400 mg/kg b.wt D-galactosamine. The antihepatotoxic effect of lecithin was observed in freshly isolated rat hepatocytes at concentration 100 μg/ml and was found to be similar to that of the standard silymarin used. Its in vivo hepatoprotective effect at 100 mg/kg b.wt was comparable with that of the standard silymarin at 100 mg/kg body weight. Lecithin was able to normalise the biochemical levels which were altered due to D-galactosamine intoxication in freshly isolated rat hepatocytes and also in animal models.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da5601d6287af4bb5f390f564f7a558a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49868006,"asset_id":4426563,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49868006/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4426563"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4426563"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4426563; 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