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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="YyT5tZ/SPP0y0f0kcf+5wXX8rKHjAaP7D+idGETxYrrLSQ5kQohr9OUep1lyGeOVgJes+QOz3GfK3j7+jS2Eiw==" /> <meta name="citation_title" content="Role of immunoglobulins in neonatal sepsis" /> <meta name="citation_publication_date" content="2015/01/01" /> <meta name="citation_journal_title" content="Translational Medicine @ UniSa" /> <meta name="citation_author" content="FEDERICA IZZO" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis" /> <meta name="twitter:title" content="Role of immunoglobulins in neonatal sepsis" /> <meta name="twitter:description" content="Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune" /> <meta name="twitter:image" content="https://0.academia-photos.com/244473959/99052558/88179455/s200_federica.izzo.png" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis" /> <meta property="og:title" content="Role of immunoglobulins in neonatal sepsis" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune" /> <meta property="article:author" content="https://independent.academia.edu/FEDERICAIZZO10" /> <meta name="description" content="Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune" /> <title>(PDF) Role of immunoglobulins in neonatal sepsis | FEDERICA IZZO - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '92477ec68c09d28ae4730a4143c926f074776319'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732800846000); window.Aedu.timeDifference = new Date().getTime() - 1732800846000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.","author":[{"@context":"https://schema.org","@type":"Person","name":"FEDERICA IZZO"}],"contributor":[],"dateCreated":"2022-11-09","dateModified":null,"datePublished":"2015-01-01","headline":"Role of immunoglobulins in neonatal sepsis","inLanguage":"en","keywords":["Medicine","Sepsis","Antibody","Neonatal Sepsis","Immunoglobulins","Neonate"],"locationCreated":null,"publication":"Translational Medicine @ UniSa","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Translational medicine @ UniSa"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link 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The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.","publisher":"Translational medicine @ UniSa","publication_date":"2015,,","publication_name":"Translational Medicine @ UniSa"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Role of immunoglobulins in neonatal sepsis","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [244473959]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":93940870,"attachmentType":"pdf"}"><img alt="First page of “Role of immunoglobulins in neonatal sepsis”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/93940870/mini_magick20221109-1-uzl5yq.png?1667988214" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Role of immunoglobulins in neonatal sepsis</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="244473959" href="https://independent.academia.edu/FEDERICAIZZO10"><img alt="Profile image of FEDERICA IZZO" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/244473959/99052558/88179455/s65_federica.izzo.png" />FEDERICA IZZO</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2015, Translational Medicine @ UniSa</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">6 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 90355451; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=90355451"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { const viewCountNumber = Number(viewCount); if (!viewCountNumber) { throw new Error('Failed to parse view count'); } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (viewCountBody) { viewCountBody.textContent = `${commaizedViewCount} views`; } else { throw new Error('Failed to find work views element'); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Neonates, especially VLBW, are at high risk for sepsis related morbidity and mortality for immaturity of their immune system and invasive NICU practices. The paucity of immunoglobulins in preterm neonates consequently to the immaturity of immune system contributes to their high risk for systemic infection. The use of intravenous IgM enriched immunoglobulins, with higher antimicrobial activity than standard IgG, has been demonstrated in a retrospective study to reduce short term mortality in VLBW infant with proven sepsis. Larger, randomized prospective trials given the enormous burden of morbidity and mortality imposed by neonatal sepsis should urgently be addressed not only to validate this results but also to tailor the optimal scheme of treatment.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":93940870,"attachmentType":"pdf","workUrl":"https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":93940870,"attachmentType":"pdf","workUrl":"https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="93940870" data-landing_url="https://www.academia.edu/90355451/Role_of_immunoglobulins_in_neonatal_sepsis" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="93255343" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies">A Study to Assess the Importance of Intravenous Immunoglobulin (Ivig) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="250465137" href="https://independent.academia.edu/MannanMalik3">Mannan Malik</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Study to Assess the Importance of Intravenous Immunoglobulin (Ivig) as an Adjuvant in the Treatment of Neonatal Sepsis in Preterm Babies","attachmentId":96043012,"attachmentType":"pdf","work_url":"https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93255343/A_Study_to_Assess_the_Importance_of_Intravenous_Immunoglobulin_Ivig_as_an_Adjuvant_in_the_Treatment_of_Neonatal_Sepsis_in_Preterm_Babies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="83750309" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis">Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63989664" href="https://independent.academia.edu/AldoBancalari">Aldo Bancalari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Neonatal-Perinatal Medicine, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">BACKGROUND: Neonatal infections are a leading cause of morbi-mortality despite advances in antimicrobials and neonatal care. Preterm infants have greater susceptibility to sepsis due to an immature immune system and lower immunoglobulin levels. Intravenous immunoglobulins (IVIG) have been used in several studies as an adjuvant treatment to improve this physiological immune deficiency, with different outcomes. METHODS: Very low birth weight (VLBW) infants who developed sepsis in the neonatal ICU were studied. They were randomly divided in 2 groups: one group was treated with antibiotics (Group I), and the other received antibiotics plus a 500 mg/kg/day of IVIG during 7 days (Group II). Serum IgG concentration was determined at initiation, during and after treatment Group I, and daily during the 7 days of therapy in Group II. RESULTS: The baseline IgG concentration in group II was 486 g/dL, and increased to 852 mg/dL after the first dose of IVIG (p</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis","attachmentId":88994346,"attachmentType":"pdf","work_url":"https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83750309/Prolonged_intravenous_immunoglobulin_treatment_in_very_low_birth_weight_infants_with_late_onset_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="69160562" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study">Effect of Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis: A Clinical Trial Study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47645342" href="https://independent.academia.edu/saadathossein">hossein saadat</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Healthmedica, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis: A Clinical Trial Study","attachmentId":79362603,"attachmentType":"pdf","work_url":"https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/69160562/Effect_of_Intravenous_Immunoglobulin_in_Prevention_of_Preterm_Neonatal_Sepsis_A_Clinical_Trial_Study"><span 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data-collection-position="4" data-entity-id="124799840" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124799840/Immunoglobulins_in_neonatal_sepsis_has_the_final_word_been_said">Immunoglobulins in neonatal sepsis: has the final word been said?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="318530694" href="https://independent.academia.edu/TeresaFerrara14">Teresa Ferrara</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Early Human Development, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunoglobulins in neonatal sepsis: has the final word been said?","attachmentId":118958304,"attachmentType":"pdf","work_url":"https://www.academia.edu/124799840/Immunoglobulins_in_neonatal_sepsis_has_the_final_word_been_said","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124799840/Immunoglobulins_in_neonatal_sepsis_has_the_final_word_been_said"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="98441844" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis">Intravenous Immunoglobulin in Neonatal Sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="261377943" href="https://independent.academia.edu/GautamMaheshKumar">Mahesh Kumar Gautam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Nepal Paediatric Society, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal be...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intravenous Immunoglobulin in Neonatal Sepsis","attachmentId":99792213,"attachmentType":"pdf","work_url":"https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/98441844/Intravenous_Immunoglobulin_in_Neonatal_Sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="18323843" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G">Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40422752" href="https://independent.academia.edu/MarthaEibl">Martha Eibl</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38316079" href="https://meduniwien.academia.edu/AngelikaBerger">Angelika Berger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G","attachmentId":39995097,"attachmentType":"pdf","work_url":"https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18323843/Preterm_infants_with_low_immunoglobulin_G_levels_have_increased_risk_of_neonatal_sepsis_but_do_not_benefit_from_prophylactic_immunoglobulin_G"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="19471008" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19471008/The_influence_of_IgM_enriched_immunoglobulin_therapy_on_neonatal_mortality_and_hematological_variables_in_newborn_infants_with_blood_culture_proven_sepsis">The influence of IgM-enriched immunoglobulin therapy on neonatal mortality and hematological variables in newborn infants with blood culture-proven sepsis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39683660" href="https://unina.academia.edu/FrancescoRaimondi">Francesco Raimondi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Turkish journal of pediatrics</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The influence of IgM-enriched immunoglobulin therapy on neonatal mortality and hematological variables in newborn infants with blood culture-proven sepsis","attachmentId":40638727,"attachmentType":"pdf","work_url":"https://www.academia.edu/19471008/The_influence_of_IgM_enriched_immunoglobulin_therapy_on_neonatal_mortality_and_hematological_variables_in_newborn_infants_with_blood_culture_proven_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19471008/The_influence_of_IgM_enriched_immunoglobulin_therapy_on_neonatal_mortality_and_hematological_variables_in_newborn_infants_with_blood_culture_proven_sepsis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="124799850" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124799850/Adjuvant_therapy_in_septic_neonates_with_immunoglobulin_preparationscontaining_Ig_isotypes_in_addition_to_IgG_A_critical_review_of_currentliterature">Adjuvant therapy in septic neonates with immunoglobulin preparationscontaining Ig isotypes in addition to IgG: A critical review of currentliterature</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="318530694" href="https://independent.academia.edu/TeresaFerrara14">Teresa Ferrara</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Current Pediatric Research, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Preterm VLBW neonates are extremely susceptible to sepsis and its consequences in terms of morbidity and mortality. This susceptibility to sepsis is related either to the immaturity of their immune system either to the exposure to invasive NICU maneuvers. The paucity of immunoglobulins contributes to the high risk of systemic infection. Very recent data on critical septic adults demonstrated that IgM enriched immunoglobulins reduce mortality. Available data about the role of IgM enriched immunoglobulins as adjuvant therapy in neonatal sepsis are still conflicting especially on VLBW infants that are the class of neonate more susceptible to infection. We provide a critical review on current literature.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Adjuvant therapy in septic neonates with immunoglobulin preparationscontaining Ig isotypes in addition to IgG: A critical review of currentliterature","attachmentId":118958309,"attachmentType":"pdf","work_url":"https://www.academia.edu/124799850/Adjuvant_therapy_in_septic_neonates_with_immunoglobulin_preparationscontaining_Ig_isotypes_in_addition_to_IgG_A_critical_review_of_currentliterature","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124799850/Adjuvant_therapy_in_septic_neonates_with_immunoglobulin_preparationscontaining_Ig_isotypes_in_addition_to_IgG_A_critical_review_of_currentliterature"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="43962406" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code">PHARMACEUTICAL SCIENCES SJIF Impact Factor: 7.187 A STUDY TO ASSESS THE IMPORTANCE OF INTRAVENOUS IMMUNOGLOBULIN (IVIG) AS AN ADJUVANT IN THE TREATMENT OF NEONATAL SEPSIS IN PRETERM BABIES QR code</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15402473" href="https://nagajunauniversity.academia.edu/Editoriajps">Editor iajps</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune deficient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at full term. Furthermore, exceptionally preterm newborn children have lessened supplement components, polymorphonuclear chemotaxis and are obligated to debilitate their capacity pools. Goals and Goals: An attempt was made to conduct this planned study with accompanying goals to focus on administering IVIG in addition to antibiotics to improve the therapeutic consequences of sepsis in premature infants. Materials and Methods: Sixty preterm infants with sepsis were randomly assigned to study and control groups in the Neonatal Intensive Care Unit of Fauji Foundation Hospital, Rawalpindi for one-year duration from May 2019 to April 2020. The study group was given IVIG in addition to standard treatment. Results: A total of 60 patients were enrolled, 30 in the study and 30 in the control group. There were no differences between the sexes (male 50%, females 50%) of the included newborns, which is also visible in the study (men 47.7%, women 52.3%) and the control group (males 52.3%, females 47.7 %). Conclusion: The low level of immunity in premature babies causes increased morbidity and mortality in severe infections. Using IVIG along with antibiotics and other supportive therapies may improve outcome.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"PHARMACEUTICAL SCIENCES SJIF Impact Factor: 7.187 A STUDY TO ASSESS THE IMPORTANCE OF INTRAVENOUS IMMUNOGLOBULIN (IVIG) AS AN ADJUVANT IN THE TREATMENT OF NEONATAL SEPSIS IN PRETERM BABIES QR code","attachmentId":64289846,"attachmentType":"pdf","work_url":"https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43962406/PHARMACEUTICAL_SCIENCES_SJIF_Impact_Factor_7_187_A_STUDY_TO_ASSESS_THE_IMPORTANCE_OF_INTRAVENOUS_IMMUNOGLOBULIN_IVIG_AS_AN_ADJUVANT_IN_THE_TREATMENT_OF_NEONATAL_SEPSIS_IN_PRETERM_BABIES_QR_code"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":93940870,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":93940870,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_93940870" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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href="https://www.academia.edu/50832753/L_administration_d_immunoglobulines_intraveineuses_n_est_pas_sans_risque_durant_la_p%C3%A9riode_n%C3%A9onatale">L’administration d’immunoglobulines intraveineuses n’est pas sans risque durant la période néonatale</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="194962700" href="https://independent.academia.edu/CostantinoDeGiacomo">Costantino De Giacomo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives de Pédiatrie, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"L’administration d’immunoglobulines intraveineuses n’est pas sans risque durant la période 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intravenous administration of immune globulin in preterm infants: Effect on serum immunoglobulin concentrations during the first year of life</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58351060" href="https://independent.academia.edu/GPardalos">G. Pardalos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Pediatrics, 1991</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prophylactic intravenous administration of immune globulin in preterm infants: Effect on serum immunoglobulin concentrations during the first year of life","attachmentId":70063265,"attachmentType":"pdf","work_url":"https://www.academia.edu/53132479/Prophylactic_intravenous_administration_of_immune_globulin_in_preterm_infants_Effect_on_serum_immunoglobulin_concentrations_during_the_first_year_of_life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/53132479/Prophylactic_intravenous_administration_of_immune_globulin_in_preterm_infants_Effect_on_serum_immunoglobulin_concentrations_during_the_first_year_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="117497725" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117497725/Umbilical_Cord_Blood_IgA_Levels_and_Bacterial_Profile_in_Preterm_Neonates_Born_with_Maternal_Risk_Factors_for_Early_Onset_Neonatal_Sepsis_Authors_Reply">Umbilical Cord Blood IgA Levels and Bacterial Profile in Preterm Neonates Born with Maternal Risk Factors for Early-Onset Neonatal Sepsis: Authors’ Reply</a><div 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href="https://hms-harvard.academia.edu/OferLevy">Ofer Levy</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Perinatology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis","attachmentId":75148561,"attachmentType":"pdf","work_url":"https://www.academia.edu/62353309/Potential_of_immunomodulatory_agents_for_prevention_and_treatment_of_neonatal_sepsis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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