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Lichtheimia corymbifera - Wikipedia
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href="https://ja.wikipedia.org/wiki/%E3%83%AA%E3%82%AF%E3%83%86%E3%82%A4%E3%83%9F%E3%82%A2%E3%83%BB%E3%82%B3%E3%83%AA%E3%83%B3%E3%83%93%E3%83%95%E3%82%A7%E3%83%A9" title="リクテイミア・コリンビフェラ – Japanese" lang="ja" hreflang="ja" data-title="リクテイミア・コリンビフェラ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/Lichtheimia_corymbifera" title="Lichtheimia corymbifera – Russian" lang="ru" hreflang="ru" data-title="Lichtheimia corymbifera" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-szl mw-list-item"><a href="https://szl.wikipedia.org/wiki/Lichtheimia_corymbifera" title="Lichtheimia corymbifera – Silesian" lang="szl" hreflang="szl" data-title="Lichtheimia corymbifera" data-language-autonym="Ślůnski" 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searchaux" style="display:none">Species of fungus</div> <p class="mw-empty-elt"> </p> <table class="infobox biota" style="text-align: left; width: 200px; font-size: 100%"> <tbody><tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><i>Lichtheimia corymbifera</i> </th></tr> <tr> <td colspan="2" style="text-align: center"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Absidia_corymbifera.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Absidia_corymbifera.jpg/220px-Absidia_corymbifera.jpg" decoding="async" width="220" height="220" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Absidia_corymbifera.jpg/330px-Absidia_corymbifera.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Absidia_corymbifera.jpg/440px-Absidia_corymbifera.jpg 2x" data-file-width="600" data-file-height="600" /></a></span> </td></tr> <tr> <th colspan="2" style="color:inherit; min-width:15em; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Taxonomy_(biology)" title="Taxonomy (biology)">Scientific classification</a> <span class="plainlinks taxobox-edit-taxonomy skin-invert" style="font-size:smaller; float:right; padding-right:0.4em; margin-left:-3em;"><span typeof="mw:File"><a href="/wiki/Template:Taxonomy/Lichtheimia" title="Edit this classification"><img alt="Edit this classification" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/15px-OOjs_UI_icon_edit-ltr.svg.png" decoding="async" width="15" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/23px-OOjs_UI_icon_edit-ltr.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/30px-OOjs_UI_icon_edit-ltr.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span> </th></tr> <tr> <td>Domain: </td> <td><a href="/wiki/Eukaryote" title="Eukaryote">Eukaryota</a> </td></tr> <tr> <td>Kingdom: </td> <td><a href="/wiki/Fungus" title="Fungus">Fungi</a> </td></tr> <tr> <td>Division: </td> <td><a href="/wiki/Mucoromycota" title="Mucoromycota">Mucoromycota</a> </td></tr> <tr> <td>Class: </td> <td><a href="/wiki/Mucorales" title="Mucorales">Mucoromycetes</a> </td></tr> <tr> <td>Order: </td> <td><a href="/wiki/Mucorales" title="Mucorales">Mucorales</a> </td></tr> <tr> <td>Family: </td> <td><a href="/wiki/Lichtheimiaceae" title="Lichtheimiaceae">Lichtheimiaceae</a> </td></tr> <tr> <td>Genus: </td> <td><a href="/wiki/Lichtheimia" title="Lichtheimia"><i>Lichtheimia</i></a> </td></tr> <tr> <td>Species: </td> <td><div style="display:inline" class="species"><i><b>L. corymbifera</b></i></div> </td></tr> <tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Binomial_nomenclature" title="Binomial nomenclature">Binomial name</a> </th></tr> <tr> <td colspan="2" style="text-align: center"><b><span class="binomial"><span style="font-weight:normal;"></span><i>Lichtheimia corymbifera</i></span></b><br /><div style="font-size: 85%;">(Cohn) Vuill. (1903)</div> </td></tr> <tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Synonym_(taxonomy)" title="Synonym (taxonomy)">Synonyms</a> </th></tr> <tr> <td colspan="2" style="text-align: left"> <p><small>≡<i>Mucor corymbifer</i> Cohn ex. Lichtheim (1884)</small><br /> <small>≡<i>Absidia corymbifera</i> (Cohn) Sacc. & Trotter</small><br /> <small>≡<i>Mycocladus corymbifer</i> (Cohn) Vánová (1991)</small><br /> <small>=<i>L. hyalospora</i> K. Hoffmann, G.Walther & K.Voigt (2009)</small><br /> <small>=<i>L. sphaerocystis</i> A. Alastruey-Izquierdo & G.Walther(2010)</small><br /> <small>=<i>L. hongkongensis</i> K.Y. Yuen (2010)</small> </p> </td></tr> </tbody></table><style data-mw-deduplicate="TemplateStyles:r1238732961">@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-night .mw-parser-output .infobox.biota img{background:transparent}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-os .mw-parser-output .infobox.biota img{background:white}}.mw-parser-output .infobox.biota .taxobox-edit-taxonomy img{background:transparent!important}body.skin-vector .mw-parser-output table.biota.infobox{margin-top:0.5em}body.skin--responsive .mw-parser-output table.biota.infobox tr.taxonrow td{padding:2px 10px}</style> <p><i><b>Lichtheimia corymbifera</b></i> is a thermophilic fungus in the phylum <a href="/wiki/Zygomycota" title="Zygomycota">Zygomycota</a>. It normally lives as a <a href="/wiki/Saprotrophic" class="mw-redirect" title="Saprotrophic">saprotrophic</a> mold, but can also be an opportunistic pathogen known to cause pulmonary, CNS, rhinocerebral, or cutaneous infections in animals and humans with impaired immunity.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Appearance">Appearance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lichtheimia_corymbifera&action=edit&section=1" title="Edit section: Appearance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1237032888/mw-parser-output/.tmulti">.mw-parser-output .tmulti .multiimageinner{display:flex;flex-direction:column}.mw-parser-output .tmulti .trow{display:flex;flex-direction:row;clear:left;flex-wrap:wrap;width:100%;box-sizing:border-box}.mw-parser-output .tmulti .tsingle{margin:1px;float:left}.mw-parser-output .tmulti .theader{clear:both;font-weight:bold;text-align:center;align-self:center;background-color:transparent;width:100%}.mw-parser-output .tmulti .thumbcaption{background-color:transparent}.mw-parser-output .tmulti .text-align-left{text-align:left}.mw-parser-output .tmulti .text-align-right{text-align:right}.mw-parser-output .tmulti .text-align-center{text-align:center}@media all and (max-width:720px){.mw-parser-output .tmulti .thumbinner{width:100%!important;box-sizing:border-box;max-width:none!important;align-items:center}.mw-parser-output .tmulti .trow{justify-content:center}.mw-parser-output .tmulti .tsingle{float:none!important;max-width:100%!important;box-sizing:border-box;text-align:center}.mw-parser-output .tmulti .tsingle .thumbcaption{text-align:left}.mw-parser-output .tmulti .trow>.thumbcaption{text-align:center}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .tmulti .multiimageinner img{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .tmulti .multiimageinner img{background-color:white}}</style><div class="thumb tmulti tleft"><div class="thumbinner multiimageinner" style="width:208px;max-width:208px"><div class="trow"><div class="tsingle" style="width:102px;max-width:102px"><div class="thumbimage"><span typeof="mw:File"><a href="/wiki/File:Absidia_corymbifera_apophysis.jpeg" class="mw-file-description"><img alt="apophysis" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Absidia_corymbifera_apophysis.jpeg/100px-Absidia_corymbifera_apophysis.jpeg" decoding="async" width="100" height="100" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Absidia_corymbifera_apophysis.jpeg/150px-Absidia_corymbifera_apophysis.jpeg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Absidia_corymbifera_apophysis.jpeg/200px-Absidia_corymbifera_apophysis.jpeg 2x" data-file-width="402" data-file-height="402" /></a></span></div></div><div class="tsingle" style="width:102px;max-width:102px"><div class="thumbimage"><span typeof="mw:File"><a href="/wiki/File:Absidia_corymbifera_sporangium.jpg" class="mw-file-description"><img alt="sporangium" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Absidia_corymbifera_sporangium.jpg/100px-Absidia_corymbifera_sporangium.jpg" decoding="async" width="100" height="100" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Absidia_corymbifera_sporangium.jpg/150px-Absidia_corymbifera_sporangium.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Absidia_corymbifera_sporangium.jpg/200px-Absidia_corymbifera_sporangium.jpg 2x" data-file-width="472" data-file-height="472" /></a></span></div></div></div><div class="trow" style="display:flex"><div class="thumbcaption"><i>Lichtheimia corymbifera</i> apophysis (left) and sporangium (right).</div></div></div></div> <p><i>Lichtheimia corymbifera</i> was originally described as <i>Mucor corymbifer</i> in 1884 by Lichtheim from clinical isolations in <a href="/wiki/Wroc%C5%82aw" title="Wrocław">Wrocław</a>, Poland.<sup id="cite_ref-lichtheim1884_2-0" class="reference"><a href="#cite_note-lichtheim1884-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup class="reference nowrap"><span title="Page / location: 149">: 149 </span></sup> At the time of the description, the species epithet, "corymbifer" was attributed to Cohn. In 1903, the fungus was transferred to the mucoralean genus <i>Lichtheimia</i> (honoring Lichtheim) by Jules Vuillemin as <i>L. corymbifera</i>. In 1912 the species was again transferred by Saccardo and Trotter to the genus <i>Absidia</i> as <i>A. corymbifera</i> where it remained for most of the 20th century. Alastruey-Izquierdo and colleagues in 1991 transferred the species to the genus <i>Mycocladus</i>, described originally by Beauverie in 1900. The type of <i>Mycocladus</i> has since been shown to be a co-culture with elements that appear to be conspecific with <i>Absidia</i> van Tieghem (1876).<sup id="cite_ref-hoffmann2010_3-0" class="reference"><a href="#cite_note-hoffmann2010-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Thus the oldest available name for the fungus is <i>Lichthemia corymbifera</i>.<sup id="cite_ref-hoffmann2010_3-1" class="reference"><a href="#cite_note-hoffmann2010-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup class="reference nowrap"><span title="Page / location: 441">: 441 </span></sup><sup id="cite_ref-alastruey-izquierdo2010_4-0" class="reference"><a href="#cite_note-alastruey-izquierdo2010-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Although conventionally treated in the family Mucoraceae, the erection of a new family to accommodate the genus <i>Lichtheimia</i>, the "Lichtheimiaceae", has been proposed.<sup id="cite_ref-hoffmann2010_3-2" class="reference"><a href="#cite_note-hoffmann2010-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup class="reference nowrap"><span title="Page / location: 445">: 445 </span></sup> </p><p><i>Lichtheimia corymbifera</i> produces small, dark spores inside pear-shaped (pyriform) <a href="/wiki/Sporangia" class="mw-redirect" title="Sporangia">sporangia</a>.<sup id="cite_ref-Ransohoff_5-0" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The species is characterized by a conically shaped columella and a short, pronounced projection, a funnel-shaped apophysis, on the top. The sporangiophores (sporangia-bearing stalks) are <a href="/wiki/Hyaline" title="Hyaline">hyaline</a> to slightly pigmented, sometimes branched, and arising from <a href="/wiki/Stolons" class="mw-redirect" title="Stolons">stolons</a> in groups of three to seven. The <a href="/wiki/Zygospores" class="mw-redirect" title="Zygospores">zygospores</a> are naked with equatorial rings, have opposed suspensors, and lack appendages. There is limited production of <a href="/wiki/Rhizoids" class="mw-redirect" title="Rhizoids">rhizoids</a>, thus, it is often difficult to identify them without the assistance of a dissecting microscope.<sup id="cite_ref-alastruey-izquierdo2010_4-1" class="reference"><a href="#cite_note-alastruey-izquierdo2010-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p><i>Lichtheimia corymbifera</i> produces more compact, less effusive growth than <a href="/wiki/Lichtheimia_ramosa" title="Lichtheimia ramosa"><i>L. ramosa</i>.</a> As well, the sporangiospores of <i>L. corymbifera</i> are ellipsodial and <a href="/wiki/Hyaline" title="Hyaline">hyaline</a> when mature, versus those of <i>L. ramosa</i> which are lightly colored and ellipsodial.<sup id="cite_ref-Garcia-HermosoHoinard2009_6-0" class="reference"><a href="#cite_note-Garcia-HermosoHoinard2009-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Ecology">Ecology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lichtheimia_corymbifera&action=edit&section=2" title="Edit section: Ecology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Originally described in Central Europe, the fungus has been found in the Middle East, Great Britain, North and South America, India, and Africa.<sup id="cite_ref-Ransohoff_5-1" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> It is usually found inhabiting soil or dead plant material,<sup id="cite_ref-alastruey-izquierdo2010_4-2" class="reference"><a href="#cite_note-alastruey-izquierdo2010-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ransohoff_5-2" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> and in association with farm animals, such as cattle and horses, probably because it decomposes hay and grass.<sup id="cite_ref-Ransohoff_5-3" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Infections in farm animals can cause death relatively quickly if not treated immediately.<sup id="cite_ref-Ransohoff_5-4" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The fungus was described as a cause of mycotic abortion in cattle in <a href="/wiki/Po_Valley" title="Po Valley">Po Valley</a>, Italy.<sup id="cite_ref-PiancastelliGhidini2009_7-0" class="reference"><a href="#cite_note-PiancastelliGhidini2009-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>The natural environment for <i>L. corymbifera</i> appears to be soil and decaying grasses, with an optimal pH between 3.0-8.0.<sup id="cite_ref-Ransohoff_5-5" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In addition, it has an optimal soil depth of 30–40 cm, according to a study in India.<sup id="cite_ref-Ransohoff_5-6" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> However, they can also be found in the air or underground and can survive on humans and animals, giving it its infectious quality.<sup id="cite_ref-Ransohoff_5-7" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Furthermore, <i>L. corymbifera</i> can survive well in humid environments, for example, in swamps, dung, grasslands or sewage, in cotton, grains and straw as well.<sup id="cite_ref-Ransohoff_5-8" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <i>Lichtheimia corymbifera</i> has optimal growth at human body temperature, 35-37 °C; however, due to its thermophilic nature, it can tolerate temperatures up to 50 °C.<sup id="cite_ref-dotf_8-0" class="reference"><a href="#cite_note-dotf-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <i>Lichthemia corymbifera</i> is a fast-growing species in both culture and in vivo. In culture, the fungus is pale white at first and turns grey with age; the colonies are observed to reach up to 15 mm in thickness.<sup id="cite_ref-life_9-0" class="reference"><a href="#cite_note-life-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The fungus can also be cultured on a range of other materials including bread.<sup id="cite_ref-Ransohoff_5-9" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lichtheimia_corymbifera&action=edit&section=3" title="Edit section: Epidemiology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Lichtheimia corymbifera</i> accounts for approximately 5% of mucormycoses today,<sup id="cite_ref-alastruey-izquierdo2010_4-3" class="reference"><a href="#cite_note-alastruey-izquierdo2010-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> but true prevalence is unclear because the disease is not generally reportable and the diagnosis of mucormycosis is often empirical or based on the recovery of any zygomycetous fungus.<sup id="cite_ref-Garcia-HermosoHoinard2009_6-1" class="reference"><a href="#cite_note-Garcia-HermosoHoinard2009-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Infection can occur in people with normal immune systems but contraction is rare if the person is merely in contact with infected soil.<sup id="cite_ref-Ransohoff_5-10" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> On the other hand, infection is common in individuals with weakened immune systems due to diseases like HIV/AIDS.<sup id="cite_ref-Ransohoff_5-11" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> A 100% mortality rate has been reported for individuals with HIV/AIDS who become infected with <i>L. corymbifera</i>.<sup id="cite_ref-Ransohoff_5-12" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Other immunodeficiency diseases that predispose to infection are diabetes, blood cancers like leukemia or large skin wounds such as those secondary to burn injury.<sup id="cite_ref-Ransohoff_5-13" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In patients with leukemia, the mortality rate is 1%.<sup id="cite_ref-Ransohoff_5-14" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> In humans, mucormycosis caused by <i>L. corymbifera</i> typically involves deep infection of the rhinocerebral and bronchorespiratory tract.<sup id="cite_ref-SchrodlHeydel2011_10-0" class="reference"><a href="#cite_note-SchrodlHeydel2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The most common presentation in farm animals is mycotic abortion.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>Infection is promoted in immunosuppressed organisms through spore inhalation or direct contact of <i>L. corymbifera</i> spores with tissues.<sup id="cite_ref-AlmaslamaniTaj-Aldeen2009_12-0" class="reference"><a href="#cite_note-AlmaslamaniTaj-Aldeen2009-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Upon infection, the fungus invades the blood vessels and there is nearby tissue destruction or blood clot formation.<sup id="cite_ref-Ransohoff_5-15" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Symptoms can be seen in various organ systems. For example, if the abdomen is infected, diagnosis is difficult since it is similar to an abscess presentation. Hence, diagnosis is often only made at death.<sup id="cite_ref-Ransohoff_5-16" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Diagnosis is also difficult if the lungs are infected. X-rays are often inconclusive in differentiating between other infections. If the sinus/craniofacial area is infected, symptoms begin with facial pain, progressing to muscle or nerve impairment in the eye area, and ultimately leading to the formation of blood clots in arteries serving the brain.<sup id="cite_ref-Ransohoff_5-17" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lichtheimia_corymbifera&action=edit&section=4" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Treatment involves a combination of surgical <a href="/wiki/Debridement" title="Debridement">debridement</a> and antifungal therapy. <i>Lichtheimia corymbifera</i> is most susceptible to the antifungal drug <a href="/wiki/Amphotericin_B" title="Amphotericin B">Amphotericin B</a> and <a href="/wiki/Posaconazole" title="Posaconazole">Posaconazole</a>,<sup id="cite_ref-SchrodlHeydel2011_10-1" class="reference"><a href="#cite_note-SchrodlHeydel2011-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> however, negative side effects are possible. These side effects can be relatively mild, resulting in chills and muscle pain but can also include severe forms of nephrotoxicity.<sup id="cite_ref-Ransohoff_5-18" class="reference"><a href="#cite_note-Ransohoff-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Amphotericin_B" title="Amphotericin B">Amphotericin B</a> binds to ergosterol, found in fungal cell membranes. This causes ion and sugar leakage progressing to cell death. This species is variably susceptible to <a href="/wiki/Itraconazole" title="Itraconazole">Itraconazole</a> and highly resistant to <a href="/wiki/Fluconazole" title="Fluconazole">Fluconazole</a>, <a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a>, <a href="/wiki/Voriconazole" title="Voriconazole">Voriconazole</a> and <a href="/wiki/Echinocandins" class="mw-redirect" title="Echinocandins">Echinocandins</a>.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Higher doses must be administered for these antifungal drugs to be effective. Other species of <i>Lichtheimia</i> are morphologically and genetically distinct but share highly similar antifungal drug susceptibilities. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lichtheimia_corymbifera&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text">Fungal Infections, Lichtheimia corymbifera. (2013). Retrieved from October 10, 2013 from the Leading International Fungal Education (LIFE) Web Site: <a rel="nofollow" class="external free" href="http://www.life-worldwide.org/fungal-diseases/lichtheimia-corymbifera/">http://www.life-worldwide.org/fungal-diseases/lichtheimia-corymbifera/</a>.</span> </li> <li id="cite_note-lichtheim1884-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-lichtheim1884_2-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFLichtheim1884" class="citation journal cs1">Lichtheim, L. (1884). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=XP81AQAAMAAJ&pg=PA140">"Ueber pathogene Mucorineen und die durch sie erzeugten Mykosen des Kaninchens"</a>. <i>Zeitschrift für klinische Medizin</i>. <b>7</b>: 140–177<span class="reference-accessdate">. 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(2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264171">"Direct Analysis and Identification of Pathogenic Lichtheimia Species by Matrix-Assisted Laser Desorption Ionization-Time of Flight Analyzer-Mediated Mass Spectrometry"</a>. <i>Journal of Clinical Microbiology</i>. <b>50</b> (2): 419–427. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.01070-11">10.1128/JCM.01070-11</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0095-1137">0095-1137</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264171">3264171</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22135259">22135259</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Direct+Analysis+and+Identification+of+Pathogenic+Lichtheimia+Species+by+Matrix-Assisted+Laser+Desorption+Ionization-Time+of+Flight+Analyzer-Mediated+Mass+Spectrometry&rft.volume=50&rft.issue=2&rft.pages=419-427&rft.date=2011&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3264171%23id-name%3DPMC&rft.issn=0095-1137&rft_id=info%3Apmid%2F22135259&rft_id=info%3Adoi%2F10.1128%2FJCM.01070-11&rft.aulast=Schr%C3%B6dl&rft.aufirst=W.&rft.au=Heydel%2C+T.&rft.au=Schwartze%2C+V.+U.&rft.au=Hoffmann%2C+K.&rft.au=Grosse-Herrenthey%2C+A.&rft.au=Walther%2C+G.&rft.au=Alastruey-Izquierdo%2C+A.&rft.au=Rodriguez-Tudela%2C+J.+L.&rft.au=Olias%2C+P.&rft.au=Jacobsen%2C+I.+D.&rft.au=de+Hoog%2C+G.+S.&rft.au=Voigt%2C+K.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3264171&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALichtheimia+corymbifera" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text">Lichtheimia corymbifera. (2013). Retrieved October 15, 2013, from The University of Adelaide, Mycology Online Web Site: <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20070920092110/http://www.mycology.adelaide.edu.au/Fungal_Descriptions/Zygomycetes/Absidia/">"Mycology Online -- Absidia"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.mycology.adelaide.edu.au/Fungal_Descriptions/Zygomycetes/Absidia/">the original</a> on 2007-09-20<span class="reference-accessdate">. Retrieved <span class="nowrap">2007-11-26</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Mycology+Online+--+Absidia&rft_id=http%3A%2F%2Fwww.mycology.adelaide.edu.au%2FFungal_Descriptions%2FZygomycetes%2FAbsidia%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALichtheimia+corymbifera" class="Z3988"></span></span> </li> <li id="cite_note-AlmaslamaniTaj-Aldeen2009-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-AlmaslamaniTaj-Aldeen2009_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAlmaslamaniTaj-AldeenGarcia-HermosoDannaoui2009" class="citation journal cs1">Almaslamani, Muna; Taj-Aldeen, Saad J.; Garcia-Hermoso, Dea; Dannaoui, Eric; Alsoub, Hussam; Alkhal, Abdullatif (2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F13693780802595746">"An increasing trend of cutaneous zygomycosis caused by Mycocladus corymbifer(formerly Absidia corymbifera): report of two cases and review of primary cutaneous Mycocladus infections"</a>. <i>Medical Mycology</i>. <b>47</b> (5): 532–538. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F13693780802595746">10.1080/13693780802595746</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1369-3786">1369-3786</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19184768">19184768</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Medical+Mycology&rft.atitle=An+increasing+trend+of+cutaneous+zygomycosis+caused+by+Mycocladus+corymbifer%28formerly+Absidia+corymbifera%29%3A+report+of+two+cases+and+review+of+primary+cutaneous+Mycocladus+infections&rft.volume=47&rft.issue=5&rft.pages=532-538&rft.date=2009&rft.issn=1369-3786&rft_id=info%3Apmid%2F19184768&rft_id=info%3Adoi%2F10.1080%2F13693780802595746&rft.aulast=Almaslamani&rft.aufirst=Muna&rft.au=Taj-Aldeen%2C+Saad+J.&rft.au=Garcia-Hermoso%2C+Dea&rft.au=Dannaoui%2C+Eric&rft.au=Alsoub%2C+Hussam&rft.au=Alkhal%2C+Abdullatif&rft_id=https%3A%2F%2Fdoi.org%2F10.1080%252F13693780802595746&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALichtheimia+corymbifera" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text">Fungal Infections, Lichtheimia corymbifera. (2013). Retrieved from October 10, 2013 from the Leading International Fungal Education (LIFE) Web Site: <a rel="nofollow" class="external free" href="http://www.life-worldwide.org/fungal-diseases/lichtheimia-corymbifera/">http://www.life-worldwide.org/fungal-diseases/lichtheimia-corymbifera/</a></span> </li> </ol></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul 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aria-labelledby="Taxon_identifiers" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Taxon_identifiers" style="font-size:114%;margin:0 4em"><a href="/wiki/Help:Taxon_identifiers" title="Help:Taxon identifiers">Taxon identifiers</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;"><i>Lichtheimia corymbifera</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><span style="white-space:nowrap;"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a>: <span class="uid"><span class="external"><a href="https://www.wikidata.org/wiki/Q4669739" class="extiw" title="wikidata:Q4669739">Q4669739</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Australian_online_fauna_%26_flora_databases" title="Australian online fauna & flora databases">AusFungi</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://id.biodiversity.org.au/name/fungi/60032601">60032601</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Barcode_of_Life_Data_System" title="Barcode of Life Data System">BOLD</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.boldsystems.org/index.php/TaxBrowser_TaxonPage?taxid=460901">460901</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Catalogue_of_Life" title="Catalogue of Life">CoL</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.catalogueoflife.org/data/taxon/6PY77">6PY77</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Global_Biodiversity_Information_Facility" title="Global Biodiversity Information Facility">GBIF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.gbif.org/species/2558326">2558326</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/INaturalist" title="INaturalist">iNaturalist</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://inaturalist.org/taxa/552982">552982</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">IndexFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.indexfungorum.org/names/NamesRecord.asp?RecordID=416447">416447</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Interim_Register_of_Marine_and_Nonmarine_Genera" title="Interim Register of Marine and Nonmarine Genera">IRMNG</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.irmng.org/aphia.php?p=taxdetails&id=10399362">10399362</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/MycoBank" title="MycoBank">MycoBank</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.mycobank.org/MB/416447">416447</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/National_Biodiversity_Network" title="National Biodiversity Network">NBN</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://data.nbn.org.uk/Taxa/BMSSYS0000047594">BMSSYS0000047594</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=42458">42458</a></span></span></li> <li><span style="white-space:nowrap;">NZOR: <span class="uid"><a rel="nofollow" class="external text" href="https://www.nzor.org.nz/names/75cd6db4-88fe-48f1-bfa0-0528784a5048">75cd6db4-88fe-48f1-bfa0-0528784a5048</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Open_Tree_of_Life" title="Open Tree of Life">Open Tree of Life</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://tree.opentreeoflife.org/taxonomy/browse?id=474685">474685</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">SpeciesFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.speciesfungorum.org/Names/NamesRecord.asp?RecordID=416447">416447</a></span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;"><i>Mucor corymbifer</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><span style="white-space:nowrap;"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a>: <span class="uid"><span class="external"><a href="https://www.wikidata.org/wiki/Q59531417" class="extiw" title="wikidata:Q59531417">Q59531417</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Australian_online_fauna_%26_flora_databases" title="Australian online fauna & flora databases">AusFungi</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://id.biodiversity.org.au/name/fungi/60032603">60032603</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Global_Biodiversity_Information_Facility" title="Global Biodiversity Information Facility">GBIF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.gbif.org/species/5250312">5250312</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">IndexFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.indexfungorum.org/names/NamesRecord.asp?RecordID=229838">229838</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Interim_Register_of_Marine_and_Nonmarine_Genera" title="Interim Register of Marine and Nonmarine Genera">IRMNG</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.irmng.org/aphia.php?p=taxdetails&id=10398173">10398173</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/MycoBank" title="MycoBank">MycoBank</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.mycobank.org/MB/229838">229838</a></span></span></li> <li><span style="white-space:nowrap;">NZOR: <span class="uid"><a rel="nofollow" class="external text" href="https://www.nzor.org.nz/names/b6391d4a-b321-48f2-acaf-2b0ab649619b">b6391d4a-b321-48f2-acaf-2b0ab649619b</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">SpeciesFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.speciesfungorum.org/Names/NamesRecord.asp?RecordID=229838">229838</a></span></span></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by mw‐web.codfw.main‐f69cdc8f6‐dg26b Cached time: 20241124215304 Cache expiry: 2592000 Reduced expiry: false Complications: [vary‐revision‐sha1, show‐toc] CPU time usage: 0.582 seconds Real time usage: 0.868 seconds Preprocessor visited node count: 5727/1000000 Post‐expand include size: 50456/2097152 bytes Template argument size: 5288/2097152 bytes Highest expansion depth: 21/100 Expensive parser function count: 14/500 Unstrip recursion depth: 1/20 Unstrip post‐expand size: 54258/5000000 bytes Lua time usage: 0.371/10.000 seconds Lua memory usage: 7042538/52428800 bytes Number of Wikibase entities loaded: 14/400 --> <!-- Transclusion expansion time report (%,ms,calls,template) 100.00% 704.007 1 -total 31.01% 218.344 1 Template:Taxonbar 26.73% 188.168 1 Template:Speciesbox 25.84% 181.903 1 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