CINXE.COM

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class="field field--name-field-language-link field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--107 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Global</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--108 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Austria</div> </span><span class="link-text"> <div class="field 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href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--114 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden 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paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Sweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--118 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> 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field--name-field-label field--type-string field--label-hidden field--item">Ireland </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> <div id="whole-header-top" class="container-fluid"> <div class="header-top-left col-sm-2"> <div class="region region-header-top-left"> <a class="logo navbar-btn pull-left" href="/" title="Home" rel="home"> <img src="/themes/custom/alnylam/logo.svg" alt="Home" /> </a> </div> </div> <div class="header-top-middle col-sm-9"> <div class="region region-header-top-middle"> <section id="block-alnylam-topnavigation-3" class="block block-superfish block-superfishtop-navigation clearfix"> <ul id="superfish-top-navigation" class="menu sf-menu 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class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="9967" role="article" about="/node/9967" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="new Section Home" class="hidden"></span> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions 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data-settings="{"grouping":[],"row_class":"","default_row_class":true,"uses_fields":false,"items":1,"itemsDesktop":[1199,1],"itemsDesktopSmall":[979,1],"itemsTablet":[768,1],"itemsMobile":[479,1],"singleItem":true,"itemsScaleUp":false,"slideSpeed":1000,"paginationSpeed":800,"rewindSpeed":2000,"autoPlay":true,"stopOnHover":false,"navigation":false,"navigationText":["prev","next"],"prevText":"prev","nextText":"next","rewindNav":true,"scrollPerPage":false,"pagination":false,"paginationNumbers":false,"responsive":true,"responsiveRefreshRate":200,"mouseDrag":true,"touchDrag":true,"transitionStyle":"fade"}" class="owl-slider-wrapper owl-carousel"> <div><div class="views-field views-field-nothing"><span class="field-content"><div class="slide"> <div class="images-con"> <div class="desktop-show"> <img src="/sites/default/files/2025-01/abuela.jpg" width="2048" height="727" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> <div class="mobile-show"> <img src="/sites/default/files/2024-12/woman_cooking_HR5-mobile.png" width="1140" height="1800" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> <div class="inner-con"> <div class="main-title"> <h2>Silence disease</h2> </div> <div class="content-desc"> <h3>Amplify life<sup>TM</sup></h3> <div class="descr"> <p>When RNAi therapeutics silence the genes that cause disease,<br /><strong>the moments that matter most can be amplified</strong>.</p> </div> <div class="buttons-con"> <a href="/about-alnylam">ABOUT ALNYLAM ›</a> </div> </div> </div> <div class="progress-bar"> </div> </div></span></div></div> <div><div class="views-field views-field-nothing"><span class="field-content"><div class="slide"> <div class="images-con"> <div class="desktop-show"> <img src="/sites/default/files/2025-01/dancing-lady.jpg" width="2048" height="727" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> <div class="mobile-show"> <img src="/sites/default/files/2024-12/danceclass_5_HR%202.png" width="1140" height="1800" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> <div class="inner-con"> <div class="main-title"> <h2>Silence disease</h2> </div> <div class="content-desc"> <h3>Amplify life<sup>TM</sup></h3> <div class="descr"> <p>When RNAi therapeutics silence the genes that cause disease,<br /><strong>the activities you love can be amplified</strong>.</p> </div> <div class="buttons-con"> <a href="/about-alnylam">ABOUT ALNYLAM ›</a> </div> </div> </div> <div class="progress-bar"> </div> </div></span></div></div> <div><div class="views-field views-field-nothing"><span class="field-content"><div class="slide"> <div class="images-con"> <div class="desktop-show"> <img src="/sites/default/files/2024-12/fishing-old-man-desktop.jpg" width="2048" height="727" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> <div class="mobile-show"> <img src="/sites/default/files/2024-12/fishing_06_HR%202.png" width="1140" height="1800" alt="" loading="lazy" typeof="Image" class="img-responsive" /> </div> </div> <div class="inner-con"> <div class="main-title"> <h2>Silence disease</h2> </div> <div class="content-desc"> <h3>Amplify life<sup>TM</sup></h3> <div class="descr"> <p>When RNAi therapeutics silence the genes that cause disease,<br /><strong>the everyday joys of life can be amplified</strong>.</p> </div> <div class="buttons-con"> <a href="/about-alnylam">ABOUT ALNYLAM ›</a> </div> </div> </div> <div class="progress-bar"> </div> </div></span></div></div> </div> </div> </div> </div> </section> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="heading-with-cards"> <div class="heading-with-cards-section-container"> <div class="section-heading"> <div class="field field--name-field-heading field--type-text-long field--label-hidden field--item"><h2 class="text-align-center">THE LEADING RNAi THERAPEUTICS COMPANY</h2> <p class="text-align-center">Alnylam has pioneered RNA interference (RNAi) therapeutics, an innovative class of medicines that treats diseases in a different way - by silencing the genes that cause or contribute to them. We are working diligently to develop RNAi-based medicines to benefit as many patients as possible.</p> </div> </div> <div class="card-items-part"> <div class="field field--name-field-cards field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="card-it"> <div class="card-image"> <img src="/sites/default/files/2025-01/about-card-0.png" alt="icon" /> </div> <div class="have-content"> <h3>About Alnylam</h3> <div class="description"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><p>We are a biopharmaceutical company driven by science and committed to delivering transformational medicines for patients.</p> </div> </div> <div class="lear-more-btn"> <a href="/about-alnylam" >Learn More</a> </div> </div> <div class="link-btn"><a href="/about-alnylam"><img src="/sites/default/files/inline-images/circled-arrow.svg" alt="icon" /></a></div> </div> </div> <div class="field--item"> <div class="card-it"> <div class="card-image"> <img src="/sites/default/files/2025-01/pipeline-man.jpg" alt="icon" /> </div> <div class="have-content"> <h3>Our Pipeline</h3> <div class="description"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><p>Our robust pipeline of investigational RNAi therapeutics is focused on both rare and prevalent diseases in several therapeutic areas.</p> </div> </div> <div class="lear-more-btn"> <a href="/alnylam-rnai-pipeline" >Learn More</a> </div> </div> <div class="link-btn"><a href="/alnylam-rnai-pipeline"><img src="/sites/default/files/inline-images/circled-arrow.svg" alt="icon" /></a></div> </div> </div> <div class="field--item"> <div class="card-it"> <div class="card-image"> <img src="/sites/default/files/2025-01/rnai_believe.jpg" alt="icon" /> </div> <div class="have-content"> <h3>Corporate  Responsibility</h3> <div class="description"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><p>We believe that Alnylam can have a positive impact on the world beyond the medicines we make and embrace the opportunity to be a force for good.</p> </div> </div> <div class="lear-more-btn"> <a href="/about-alnylam/corporate-responsibility" >Learn More</a> </div> </div> <div class="link-btn"><a href="/about-alnylam/corporate-responsibility"><img src="/sites/default/files/inline-images/circled-arrow.svg" alt="icon" /></a></div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="image-with-content"> <div class="image-uploaded"> <video autoplay="" id="vid" loop="" muted="" playsinline="" width="100%"><source src="/sites/default/files/videos/moasnippet.mp4" type="video/mp4"><source src="/sites/default/files/videos/moasnippet.mp4" type="video/ogg"></video> </div> <div class="image-with-content-container"> <div class="section-content"> <h3>SILENCING GENES TO TREAT DISEASE</h3> <div class="description"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><p>RNA interference (RNAi) is a naturally occurring process already at work inside your body which regulates how genes make new proteins. Proteins play a critical role in almost everything your body does, but sometimes, they can cause or contribute to disease. Our medicines leverage the RNAi process to selectively target and prevent specific proteins from being made, “silencing” gene expression to treat disease at its source.</p> </div> </div> <div class="action-btn-container"> <a class="action-btn" href="/our-science/the-science-of-rnai" >MORE ABOUT RNAi ›</a> </div> </div> </div> </section> </div> <div class="field--item"> <section class="block-section carousel-side-by-side"> <h3>DRIVEN BY SCIENCE, INSPIRED BY PEOPLE</h3> <div class="description"> <p>Whether we're working to develop the first treatment for a disease, or a better one, patients are at the center of all we do. They are the reason we come to work every day, and their stories inspire us to continue innovating by pushing the science of RNAi therapeutics forward.</p> </div> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><div class="wrapper-slider pb-5"> <div class="container"> <div class="row"> <div class="item-wrapper active"> <div> <div class="description"> <div class="qoute"><img alt="icon" loading="eager" src="/sites/default/files/inline-images/cout.svg" /></div> <p>When I'm in the water I feel like I’m just like everyone else… It helps me forget that I have a disability and that I have limitations. I have an Olympic dream with my swimming.</p> </div> <h2 class="title">Glauciene</h2> <p class="subtitle">Living with Acute Intermittent Porphyria</p> <a class="ext-link" href="https://www.alnylam.com/patients/porphyria" title="More about Porphyria"><span>More about Porphyria</span> <img alt="icon" loading="eager" src="/sites/default/files/inline-images/circled-arrow.svg" /></a></div> </div>  <div class="item-wrapper"> <div> <div class="description"> <div class="qoute"><img alt="icon" loading="eager" src="/sites/default/files/inline-images/cout.svg" /></div> <p>What gives us strength is life, faith, hope and gratitude; for being able to fight for life.</p> </div> <h2 class="title">Chen</h2> <p class="subtitle">Living with hATTR Amyloidosis</p> <a class="ext-link" href="https://www.alnylam.com/patients/amyloidosis" title="More about Amyloidosis"><span>More about Amyloidosis</span> <img alt="icon" loading="eager" src="/sites/default/files/inline-images/circled-arrow.svg" /></a></div> </div>  <div class="item-wrapper"> <div> <div class="description"> <div class="qoute"><img alt="icon" loading="eager" src="/sites/default/files/inline-images/cout.svg" /></div> <p>I am hopeful. There are definitely a lot of ups and downs, and many challenges, but I have that hope that I can still live a happy life.</p> </div> <h2 class="title">Aubrey</h2> <p class="subtitle">Living with Primary Hyperoxaluria Type 1</p> <a class="ext-link" href="https://www.alnylam.com/patients/primary-hyperoxaluria" title="More about PH1"><span>More about PH1</span> <img alt="icon" loading="eager" src="/sites/default/files/inline-images/circled-arrow.svg" /></a></div> </div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="two-column-content"> <div class="inner-two-column-content"> <div class="two-column-content-container"> <div class="image-uploaded"> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2025-01/career-image.jpg" width="1112" height="1114" alt="" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> <div class="section-content"> <h3>JOIN US</h3> <div class="description"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><p>Incredible things happen when science and culture come together, and we believe that our people are our greatest strength. Together, we have built an inclusive, exceptional workplace where everyone can do their best work. To those who say impossible, impractical, unrealistic, we say, Challenge Accepted.</p> </div> </div> <div class="action-btn-container"> <a class="action-btn" href="/careers" >EXPLORE CAREERS ›</a> </div> </div> </div> </div> </section> </div> <div class="field--item"> <section class="block-section new-news"> <div class="field field--name-field-add-block-to-section field--type-entity-reference-revisions field--label-hidden field--item"> <div class="paragraph paragraph--type--add-block paragraph-id--2149 paragraph--view-mode--default"> <div class="addblock--component" id="cr-in-action" style="width:1170px; margin:auto; "> <div class="field field--name-field-add-block field--type-block-field field--label-hidden field--item"><section class="views-element-container block block-views block-views-blocknew-news-block-1 clearfix" id="block-views-block-new-news-block-1"> <div class="form-group"><div class="view view-new-news view-id-new_news view-display-id-block_1 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class="media media--blazy media--slick media--image media--ratio media--ratio--fluid is-b-loading"><img class="media__image media__element b-lazy img-responsive" decoding="async" loading="lazy" data-src="/sites/default/files/2025-02/newsweek2025%281%29.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="1410" height="867" typeof="foaf:Image" /> </div> </div> <div class="slide__caption"> <div class="slide__description"><div class="views-field views-field-nothing"><span class="field-content"><div class="news-box"> <h5>Alnylam Named a Most Responsible Company by Newsweek</h5> <div class="description-text">We are honored to be recognized for the third year in a row</div> <div class="view-article-btn"><a href="https://news.alnylam.com/responsibility/articles/alnylam-named-most-responsible-company-2025">Learn More ›</a></div> </div></span></div></div> </div> </div> </div> <div class="slick__slide slide 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