CINXE.COM

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class="field field--name-field-language-link field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--107 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Global</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--108 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Austria</div> </span><span class="link-text"> <div class="field 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class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Japan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.jp/">日本語</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--110 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Belgium</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-belgium-dutch"> Nederlands</a></div> <div class="field--item"><a href="/alnylam-belgium-french">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--109 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Luxembourg</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-luxembourg-french">Français</a></div> <div class="field--item"><a href="/alnylam-luxembourg-german"> Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--112 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Brazil </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.com.br/">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--111 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Netherlands </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--114 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Czech Republic</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--115 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Spain </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--116 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Denmark </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--117 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Sweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--118 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--119 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Switzerland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--120 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Germany </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--121 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">繁體中文</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1514 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Ireland </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="37" role="article" about="/about-alnylam" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="ABOUT ALNYLAM" class="hidden"></span> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--sim paragraph-id--35 paragraph--view-mode--default"> <div id="simple-banner-wrapper"> <div class="simple-banner" style=""> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2024-06/about-page-hero-section_0.png" width="2560" height="768" alt="ABOUT ALNYLAM" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--banner-overlay-html-content paragraph-id--66 paragraph--view-mode--default"> <div class="banner-overlay-html-content-description--component " style="width:1130px; margin:auto;"> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><p class="mobile-eyebrow"><span class="our-company">Our Company</span></p> <div class="about-alnylam "> <div class="row"> <div class="col-sm-12"> <h1 class="our-company text-align-center">ALNYLAM IS LEADING THE RNAi REVOLUTION™</h1> <p class="font-20 text-align-center mb-24 mm-b-16">Alnylam is a leading independent biopharmaceutical company and the pioneer in RNA interference (RNAi) therapeutics <span style="white-space: nowrap;">– a revolutionary</span> approach to treating diseases which “silences” the genes that cause or contribute to them.</p> <p>Founded in 2002 by a group of distinguished researchers and biotech leaders, Alnylam’s work over more than two decades has yielded the critical breakthroughs and advancements that have made the field of (RNAi) therapeutics possible. In 2018, our first commercial medicine, and the world’s first RNAi therapeutic was approved. Since then, four more Alnylam-developed medicines have been approved and we’re hard at work developing new therapies to treat both rare and prevalent diseases.</p> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <section class="two-column-html-content-background"> <div style="background-image: url(/sites/default/files/2024-06/in-a-name.png);"> <div class="row inner-block" style="width:970px; margin:auto;"> <div class="field field--name-field-content-html field--type-text-long field--label-hidden field--item"><div class="d-flex"> <div class="colm-1"> <h3>What’s in a Name?</h3> <p>AL-NY-LAM. Our name may not be the easiest to pronounce, but once you learn it, you’ll never forget it.</p> <p>Alnylam is derived from “Alnilam,” the bright center star in the constellation Orion’s belt, which has been used by navigators for thousands of years and symbolizes our passion for discovery.</p> </div> <div class="colm-2"><img alt="" src="/sites/default/files/inline-images/orions-belt.svg" /></div> </div> </div> </div> </div> </section> </div> <div class="field--item"> <div class="paragraph paragraph--type--body paragraph-id--2115 paragraph--view-mode--default"> <div class="description--component" style="width:px; margin:auto; "> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="whole-patient-comes-first-section new-video custom-video second-image" style="background:#f4f9fc"> <div class="content pl-0"> <div class="description"> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item" data-quickedit-field-id="paragraph/327/field_body/en/default"> <h2 class="text-center">The Leader in RNAi Therapeutics</h2> <p>Medicines based on RNAi work by “silencing” or disabling the production (“expression”) of the genes that cause specific diseases. Since our medicines work at a genetic level, we believe that we can develop small interfering RNAs that can silence virtually any gene in the genome, meaning that the diseases we’re treating with RNAi therapeutics today, are just the beginning of what’s possible.</p> </div> </div> </div> <div class="image-quote overlap"> <div class="image"> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item" data-quickedit-field-id="paragraph/327/field_upload_image/en/default"><img alt="whats-in-a-name" data-entity-type="file" src="/sites/default/files/inline-images/video-image.png" /></div> </div> <div class="cboxElement as" data-colorbox-inline=".patients-comes-first-video-home"> <div class="three-column-video-play-button"> </div> </div> <div class="patients-comes-first-video-home" style="display: none;"> <div class="field field--name-field-embed-video field--type-video-embed-field field--label-hidden field--item" data-once="quickedit" data-quickedit-field-id="paragraph/464/field_embed_video/en/default"> <div class="video-embed-field-provider-youtube video-embed-field-responsive-video form-group"><iframe allowfullscreen="allowfullscreen" data-gtm-yt-inspected-6886893_103="true" frameborder="0" height="480" id="566659760" src="https://www.youtube.com/embed/GNb03VDJEuE?si=zcjUPP-StgeeKKOV?start=0&rel=0" width="854"></iframe></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--add-block paragraph-id--2146 paragraph--view-mode--default"> <div class="addblock--component" id="cr-in-action" style="width:px; margin:auto; "> <div class="field field--name-field-add-block field--type-block-field field--label-hidden field--item"><section class="views-element-container block block-views block-views-blocktimelines-block-1 clearfix" id="block-views-block-timelines-block-1"> <div class="form-group"><div class="view view-timelines view-id-timelines view-display-id-block_1 js-view-dom-id-645641ac82a0f513d2a5bff18e8b06129227034f267d7cf3d051e106807b807d"> <div class="view-header"> <h2 class="text-center">Over 20 Years of Innovation</h2> <div class="d-flex justify-content-between"> <p> While Alnylam was founded in 2002, our history began before then, when Alnylam’s co-founder discovered that RNAi and siRNA could silence genes that cause disease. Since that historic discovery, Alnylam has continued to drive the RNAi Revolution™ forward, pioneering a new class of medicines for patients in need. </p> <div class="select-wrapper-location"> <select id="filter-select"><option value="*" selected="selected">Show All</option><option value="1998">1998</option><option value="1999">1999</option><option value="2002">2002</option><option value="2004">2004</option><option value="2005">2005</option><option value="2006">2006</option><option value="2010">2010</option><option value="2011">2011</option><option value="2012">2012</option><option value="2013">2013</option><option value="2016">2016</option><option value="2017">2017</option><option value="2018">2018</option><option value="2019">2019</option><option value="2020">2020</option><option value="2021">2021</option><option value="2022">2022</option><option value="2023">2023</option><option value="2024">2024</option></select></div> </div> <div id="loader" style="display: none"> <div class="spinner"></div> </div> </div> <div class="view-content"> <div class="item-list"> <ul> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">1998</h2> <div class="decription"> <p>Andrew Fire and Craig Mello publish paper describing the discovery of RNA interference</p> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">1999</h2> <div class="decription"> <p>Phillip Sharp’s 1999 <em>Genes & Development</em> perspective sparks collaboration and experimentation among Alnylam’s founders</p> <a target="_blank" class="learn-more js-inter-modal" href="https://genesdev.cshlp.org/content/13/2/139.full.pdf+html?sid=3a73960d-192e-4776-ae0a-a5ef242f0d1a">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2002</h2> <div class="decription"> <p>Alnylam is founded on June 14 by Phillip Sharp, David Bartel, Thomas Tuschl, Paul Schimmel and Phillip Zamore</p> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2002</h2> <div class="decription"> <p>Tuschl 1 and 2 patents in-licensed from MIT, Max Planck and Whitehead</p> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2004</h2> <div class="decription"> <p>Alnylam IPO and listing on the Nasdaq exchange</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=11661">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2005</h2> <div class="decription"> <p>First RNAi clinical program initiated (ALN-RSV01)</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=11896">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2006</h2> <div class="decription"> <p>Zimmerman et. al., <em>Nature</em> paper conclusively demonstrates the gene-silencing effect of RNAi therapeutics in mammals for the first time</p> <a target="_blank" class="learn-more js-inter-modal" href="https://www.nature.com/articles/nature04688">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2006</h2> <div class="decription"> <p>Discovery of RNAi awarded the Nobel Prize in Medicine and Physiology</p> <a target="_blank" class="learn-more js-inter-modal" href="https://www.nobelprize.org/prizes/medicine/2006/press-release/">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2010</h2> <div class="decription"> <p><em>Alnylam 5x15</em> five-year strategy launched</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=13766">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2011</h2> <div class="decription"> <p>First human POC for RNAi<br /> (ALN-TTR01 and ALN-TTR02)</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=13851">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2012</h2> <div class="decription"> <p>Alnylam's first manufacturing facility opens in Cambridge, Massachusetts (Alewife)</p> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2013</h2> <div class="decription"> <p>First human POC for GalNAc conjugates as a delivery mechanism</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=14646">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2013</h2> <div class="decription"> <p>First <em>NEJM</em> paper published on the safety and efficacy of patisiran</p> <a target="_blank" class="learn-more js-inter-modal" href="https://www.nejm.org/doi/full/10.1056/NEJMoa1208760">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2016</h2> <div class="decription"> <p>First Alnylam international office opens in Maidenhead, UK</p> <a target="_blank" class="learn-more js-inter-modal" href="https://www.businesswire.com/news/home/20160919006364/en/Alnylam-to-Expand-Global-Footprint-with-New-European-Office-in-Maidenhead-UK">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2016</h2> <div class="decription"> <p><em>Alnylam 2020</em> five-year strategy launched</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=15596">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2016</h2> <div class="decription"> <p>Groundbreaking for Norton Manufacturing Facility</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=15656">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2017</h2> <div class="decription"> <p>First positive Phase 3 Study for Alnylam and an RNAi therapeutic<br /> (APOLLO study for patisiran)</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=21961">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2018</h2> <div class="decription"> <p>ONPATTRO® approved in the US and EU. First-ever approved RNAi therapeutic, and Alnylam’s first commercial medicine</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=22946">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2018</h2> <div class="decription"> <p>Positive Topline Results from ENVISION Phase 3 Study of Givosiran</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=23111">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2019</h2> <div class="decription"> <p>Positive Topline Results from ILLUMINATE-A Phase 3 Study of Lumasiran</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=24376">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2019</h2> <div class="decription"> <p>Positive Complete Results from ORION-11 Phase 3 Study of Inclisiran (licensed to Medicines Company)</p> <a target="_blank" class="learn-more" href="https://news.alnylam.com/rnai/articles/orion-11-landmark-event-rnai-therapeutics">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2020</h2> <div class="decription"> <p>Positive Topline Results from ILLUMINATE-B Phase 3 Study of Lumasiran</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=25156">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2020</h2> <div class="decription"> <p>OXLUMO® (lumasiran) approved in US and EU</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=25271">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2021</h2> <div class="decription"> <p><em>Alnylam P<sup>5</sup>x25</em> five-year strategy launched</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=25376">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2021</h2> <div class="decription"> <p>GIVLAARI® (givosiran) approved in the US and EU</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=24281">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2021</h2> <div class="decription"> <p>Leqvio® (inclisiran) approved in the US and EU (licensed to Novartis)</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=26301">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2022</h2> <div class="decription"> <p>AMVUTTRA® (vutrisiran) approved in the US and EU</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=26776">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2022</h2> <div class="decription"> <p>Positive Topline Results from APOLLO-B Phase 3 Study of Patisiran in Patients with<br /> ATTR-CM</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=26851">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2022</h2> <div class="decription"> <p>Alnylam Celebrates 20th Anniversary</p> <a target="_blank" class="learn-more" href="https://www.alnylam20th.com/">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2023</h2> <div class="decription"> <p>First POC for targeted delivery of RNAi therapeutic to CNS (ALN-APP)</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=27441">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2023</h2> <div class="decription"> <p>First $1B annual in net product revenue</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=27941">LEARN MORE ›</a> </div> </div></span></div></li> <li><div class="views-field views-field-nothing"><span class="field-content"><div class="timeline-item"> <h2 class="year-title">2024</h2> <div class="decription"> <p>Positive Topline Results from HELIOS-B Phase 3 Study of Vutrisiran in Patients with ATTR-CM</p> <a target="_blank" class="learn-more" href="https://investors.alnylam.com/press-release?id=28231">LEARN MORE ›</a> </div> </div></span></div></li> </ul> </div> </div> </div> </div> </section> </div> </div> </div> </div> <div class="field--item"><section class="center-cards-section"> <div class="center-cards-container"> <h2>Leading by Example</h2> <div class="center-cards-wrapper"> <div class="field field--name-field-add-center-card field--type-entity-reference-revisions field--label-hidden field--items"> <div 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