Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

<!DOCTYPE html> <html lang="en" class="grade-c"> <head> <title>Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer | Nature Genetics</title> <link rel="alternate" type="application/rss+xml" href="https://www.nature.com/ng.rss"/> <script id="save-data-connection-testing"> function hasConnection() { return navigator.connection || navigator.mozConnection || navigator.webkitConnection || navigator.msConnection; } function createLink(src) { var preloadLink = document.createElement("link"); preloadLink.rel = "preload"; preloadLink.href = src; preloadLink.as = "font"; preloadLink.type = "font/woff2"; preloadLink.crossOrigin = ""; document.head.insertBefore(preloadLink, document.head.firstChild); } var connectionDetail = { saveDataEnabled: false, slowConnection: false }; var connection = hasConnection(); if (connection) { connectionDetail.saveDataEnabled = connection.saveData; if (/\slow-2g|2g/.test(connection.effectiveType)) { 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They identify common variants at the ABO blood group locus associated with susceptibility to pancreatic cancer, consistent with previous epidemiological evidence suggesting that individuals with A or B blood types have greater risk of this cancer than individuals with blood type O. We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10−8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12–1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.","datePublished":"2009-08-02T00:00:00Z","dateModified":"2009-08-02T00:00:00Z","pageStart":"986","pageEnd":"990","sameAs":"https://doi.org/10.1038/ng.429","keywords":["Biomedicine","general","Human Genetics","Cancer Research","Agriculture","Gene Function","Animal Genetics and Genomics"],"image":["https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.429/MediaObjects/41588_2009_Article_BFng429_Fig1_HTML.jpg","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.429/MediaObjects/41588_2009_Article_BFng429_Fig2_HTML.jpg"],"isPartOf":{"name":"Nature Genetics","issn":["1546-1718","1061-4036"],"volumeNumber":"41","@type":["Periodical","PublicationVolume"]},"publisher":{"name":"Nature Publishing Group 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Springer Nature America, Inc."/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="Stephen Chanock and colleagues report a genome-wide association study of pancreatic cancer. They identify common variants at the ABO blood group locus associated with susceptibility to pancreatic cancer, consistent with previous epidemiological evidence suggesting that individuals with A or B blood types have greater risk of this cancer than individuals with blood type O. We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10−8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12–1.28). This SNP maps to the first intron of the ABO blood group gene. 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The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann. Epidemiol. 4, 1–10 (1994)."/> <meta name="citation_reference" content="citation_journal_title=Public Health Nutr.; citation_title=European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection; citation_author=E Riboli; citation_volume=5; citation_publication_date=2002; citation_pages=1113-1124; citation_doi=10.1079/PHN2002394; citation_id=CR9"/> <meta name="citation_reference" content="citation_journal_title=Am. J. 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Cancer; citation_title=Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: results of a prospective study; citation_author=A Zeleniuch-Jacquotte; citation_volume=114; citation_publication_date=2005; citation_pages=323-327; citation_doi=10.1002/ijc.20694; citation_id=CR12"/> <meta name="citation_reference" content="citation_journal_title=Mutat. Res.; citation_title=Methods for etiologic and early marker investigations in the PLCO trial; citation_author=RB Hayes; citation_volume=592; citation_publication_date=2005; citation_pages=147-154; citation_doi=10.1016/j.mrfmmm.2005.06.013; citation_id=CR13"/> <meta name="citation_reference" content="citation_journal_title=Prev. 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Womens Health Gend. Based Med.; citation_title=Baseline characteristics of participants in the Women's Health Study; citation_author=KM Rexrode, IM Lee, NR Cook, CH Hennekens, JE Buring; citation_volume=9; citation_publication_date=2000; citation_pages=19-27; citation_doi=10.1089/152460900318911; citation_id=CR17"/> <meta name="citation_reference" content="citation_journal_title=Cancer Res.; citation_title=Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk; citation_author=RR McWilliams; citation_volume=68; citation_publication_date=2008; citation_pages=4928-4935; citation_doi=10.1158/0008-5472.CAN-07-5539; citation_id=CR18"/> <meta name="citation_reference" content="citation_journal_title=Int. J. Cancer; citation_title=Allergies are associated with reduced pancreas cancer risk: A population-based case-control study in Ontario, Canada; citation_author=A Eppel, M Cotterchio, S Gallinger; citation_volume=121; citation_publication_date=2007; citation_pages=2241-2245; citation_doi=10.1002/ijc.22884; citation_id=CR19"/> <meta name="citation_reference" content="citation_journal_title=Cancer Epidemiol. Biomarkers Prev.; citation_title=Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer; citation_author=EJ Duell; citation_volume=17; citation_publication_date=2008; citation_pages=1470-1479; citation_doi=10.1158/1055-9965.EPI-07-2797; citation_id=CR20"/> <meta name="citation_reference" content="citation_journal_title=Am. J. Gastroenterol.; citation_title=Risk factors for pancreatic cancer: case-control study; citation_author=MM Hassan; citation_volume=102; citation_publication_date=2007; citation_pages=2696-2707; citation_doi=10.1111/j.1572-0241.2007.01510.x; citation_id=CR21"/> <meta name="citation_reference" content="citation_journal_title=Cancer Detect. Prev.; citation_title=Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer; citation_author=SH Olson; citation_volume=31; citation_publication_date=2007; citation_pages=345-351; citation_doi=10.1016/j.cdp.2007.10.002; citation_id=CR22"/> <meta name="citation_reference" content="citation_journal_title=J. Natl. Cancer Inst.; citation_title=Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity; citation_author=HA Risch; citation_volume=95; citation_publication_date=2003; citation_pages=948-960; citation_doi=10.1093/jnci/95.13.948; citation_id=CR23"/> <meta name="citation_reference" content="citation_journal_title=Nat. Genet.; citation_title=Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies; citation_author=AD Skol, LJ Scott, GR Abecasis, M Boehnke; citation_volume=38; citation_publication_date=2006; citation_pages=209-213; citation_doi=10.1038/ng1706; citation_id=CR24"/> <meta name="citation_reference" content="Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678 (2007)."/> <meta name="citation_reference" content="citation_journal_title=BMJ; citation_title=A relationship between cancer of stomach and the ABO blood groups; citation_author=I Aird, HH Bentall, JA Roberts; citation_volume=1; citation_publication_date=1953; citation_pages=799-801; citation_doi=10.1136/bmj.1.4814.799; citation_id=CR26"/> <meta name="citation_reference" content="citation_journal_title=N. Engl. J. Med.; citation_title=The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human disease; citation_author=DM Marcus; citation_volume=280; citation_publication_date=1969; citation_pages=994-1006; citation_doi=10.1056/NEJM196905012801806; citation_id=CR27"/> <meta name="citation_reference" content="citation_journal_title=PLoS Genet.; citation_title=A genome-wide association study identifies protein quantitative trait loci (pQTLs); citation_author=D Melzer; citation_volume=4; citation_publication_date=2008; citation_pages=e1000072; citation_doi=10.1371/journal.pgen.1000072; citation_id=CR28"/> <meta name="citation_reference" content="citation_journal_title=PLoS Genet.; citation_title=Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women; citation_author=G Paré; citation_volume=4; citation_publication_date=2008; citation_pages=e1000118; citation_doi=10.1371/journal.pgen.1000118; citation_id=CR29"/> <meta name="citation_reference" content="citation_journal_title=Am. J. Hum. Genet.; citation_title=Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes; citation_author=X Yuan; citation_volume=83; citation_publication_date=2008; citation_pages=520-528; citation_doi=10.1016/j.ajhg.2008.09.012; citation_id=CR30"/> <meta name="citation_reference" content="citation_journal_title=J. Natl. Cancer Inst.; citation_title=Cancer-associated alterations of blood group antigen expression in the human pancreas; citation_author=SH Itzkowitz; citation_volume=79; citation_publication_date=1987; citation_pages=425-434; citation_id=CR31"/> <meta name="citation_reference" content="citation_journal_title=Nature; citation_title=Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours; citation_author=DM Berman; citation_volume=425; citation_publication_date=2003; citation_pages=846-851; citation_doi=10.1038/nature01972; citation_id=CR32"/> <meta name="citation_reference" content="citation_journal_title=J. Natl. Cancer Inst.; citation_title=ABO blood group and the risk of pancreatic cancer; citation_author=BM Wolpin; citation_volume=101; citation_publication_date=2009; citation_pages=424-431; citation_doi=10.1093/jnci/djp020; citation_id=CR33"/> <meta name="citation_reference" content="citation_journal_title=Am. J. Hum. 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Genet.; citation_title=Multiple loci identified in a genome-wide association study of prostate cancer; citation_author=G Thomas; citation_volume=40; citation_publication_date=2008; citation_pages=310-315; citation_doi=10.1038/ng.91; citation_id=CR37"/> <meta name="citation_reference" content="citation_journal_title=Nat. Genet.; citation_title=A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer; citation_author=DJ Hunter; citation_volume=39; citation_publication_date=2007; citation_pages=870-874; citation_doi=10.1038/ng2075; citation_id=CR38"/> <meta name="citation_reference" content="citation_journal_title=PLoS One; citation_title=Population substructure and control selection in genome-wide association studies; citation_author=K Yu; citation_volume=3; citation_publication_date=2008; citation_pages=e2551; citation_doi=10.1371/journal.pone.0002551; citation_id=CR39"/> <meta name="citation_reference" content="citation_journal_title=Nat. 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class="c-article-author-list c-article-author-list--long" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Laufey-Amundadottir-Aff1-Aff2" data-author-popup="auth-Laufey-Amundadottir-Aff1-Aff2" data-author-search="Amundadottir, Laufey">Laufey Amundadottir</a><sup class="u-js-hide"><a href="#Aff1">1</a>,<a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#na1">na1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Peter-Kraft-Aff3-Aff4" data-author-popup="auth-Peter-Kraft-Aff3-Aff4" data-author-search="Kraft, Peter">Peter Kraft</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff4">4</a></sup><sup class="u-js-hide"> <a href="#na1">na1</a></sup>, </li><li 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c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Gloria_M-Petersen-Aff7" data-author-popup="auth-Gloria_M-Petersen-Aff7" data-author-search="Petersen, Gloria M">Gloria M Petersen</a><sup class="u-js-hide"><a href="#Aff7">7</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Alan_A-Arslan-Aff8-Aff9-Aff10" data-author-popup="auth-Alan_A-Arslan-Aff8-Aff9-Aff10" data-author-search="Arslan, Alan A">Alan A Arslan</a><sup class="u-js-hide"><a href="#Aff8">8</a>,<a href="#Aff9">9</a>,<a href="#Aff10">10</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-H_Bas-Bueno_de_Mesquita-Aff11" data-author-popup="auth-H_Bas-Bueno_de_Mesquita-Aff11" data-author-search="Bueno-de-Mesquita, H Bas">H Bas Bueno-de-Mesquita</a><sup class="u-js-hide"><a href="#Aff11">11</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Myron-Gross-Aff12" data-author-popup="auth-Myron-Gross-Aff12" data-author-search="Gross, Myron">Myron Gross</a><sup class="u-js-hide"><a href="#Aff12">12</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Kathy-Helzlsouer-Aff13" data-author-popup="auth-Kathy-Helzlsouer-Aff13" data-author-search="Helzlsouer, Kathy">Kathy Helzlsouer</a><sup class="u-js-hide"><a href="#Aff13">13</a></sup>, </li><li 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data-author-popup="auth-Wei-Zheng-Aff16" data-author-search="Zheng, Wei">Wei Zheng</a><sup class="u-js-hide"><a href="#Aff16">16</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Demetrius-Albanes-Aff2" data-author-popup="auth-Demetrius-Albanes-Aff2" data-author-search="Albanes, Demetrius">Demetrius Albanes</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-William-Bamlet-Aff7" data-author-popup="auth-William-Bamlet-Aff7" data-author-search="Bamlet, William">William Bamlet</a><sup class="u-js-hide"><a href="#Aff7">7</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Christine_D-Berg-Aff17" data-author-popup="auth-Christine_D-Berg-Aff17" data-author-search="Berg, Christine D">Christine D Berg</a><sup class="u-js-hide"><a href="#Aff17">17</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Franco-Berrino-Aff18" data-author-popup="auth-Franco-Berrino-Aff18" data-author-search="Berrino, Franco">Franco Berrino</a><sup class="u-js-hide"><a href="#Aff18">18</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Sheila-Bingham-Aff19" data-author-popup="auth-Sheila-Bingham-Aff19" data-author-search="Bingham, Sheila">Sheila Bingham</a><sup class="u-js-hide"><a href="#Aff19">19</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Julie_E-Buring-Aff20-Aff21" data-author-popup="auth-Julie_E-Buring-Aff20-Aff21" data-author-search="Buring, Julie E">Julie E Buring</a><sup class="u-js-hide"><a href="#Aff20">20</a>,<a href="#Aff21">21</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Paige_M-Bracci-Aff22" data-author-popup="auth-Paige_M-Bracci-Aff22" data-author-search="Bracci, Paige M">Paige M Bracci</a><sup class="u-js-hide"><a href="#Aff22">22</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Federico-Canzian-Aff23" data-author-popup="auth-Federico-Canzian-Aff23" data-author-search="Canzian, Federico">Federico Canzian</a><sup class="u-js-hide"><a href="#Aff23">23</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Fran_oise-Clavel_Chapelon-Aff24" data-author-popup="auth-Fran_oise-Clavel_Chapelon-Aff24" data-author-search="Clavel-Chapelon, Françoise">Françoise Clavel-Chapelon</a><sup class="u-js-hide"><a href="#Aff24">24</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Sandra-Clipp-Aff25" data-author-popup="auth-Sandra-Clipp-Aff25" data-author-search="Clipp, Sandra">Sandra Clipp</a><sup class="u-js-hide"><a href="#Aff25">25</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Michelle-Cotterchio-Aff26" data-author-popup="auth-Michelle-Cotterchio-Aff26" data-author-search="Cotterchio, Michelle">Michelle Cotterchio</a><sup class="u-js-hide"><a href="#Aff26">26</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Mariza-de_Andrade-Aff7" data-author-popup="auth-Mariza-de_Andrade-Aff7" data-author-search="de Andrade, Mariza">Mariza de Andrade</a><sup class="u-js-hide"><a href="#Aff7">7</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Eric_J-Duell-Aff27" data-author-popup="auth-Eric_J-Duell-Aff27" data-author-search="Duell, Eric J">Eric J Duell</a><sup class="u-js-hide"><a href="#Aff27">27</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-John_W-Fox_Jr-Aff28" data-author-popup="auth-John_W-Fox_Jr-Aff28" data-author-search="Fox Jr, John W">John W Fox Jr</a><sup class="u-js-hide"><a href="#Aff28">28</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Steven-Gallinger-Aff29" data-author-popup="auth-Steven-Gallinger-Aff29" data-author-search="Gallinger, Steven">Steven Gallinger</a><sup class="u-js-hide"><a href="#Aff29">29</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-J_Michael-Gaziano-Aff30" data-author-popup="auth-J_Michael-Gaziano-Aff30" data-author-search="Gaziano, J Michael">J Michael Gaziano</a><sup class="u-js-hide"><a href="#Aff30">30</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Edward_L-Giovannucci-Aff3-Aff6-Aff31" data-author-popup="auth-Edward_L-Giovannucci-Aff3-Aff6-Aff31" data-author-search="Giovannucci, Edward L">Edward L Giovannucci</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff6">6</a>,<a href="#Aff31">31</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Michael-Goggins-Aff32" data-author-popup="auth-Michael-Goggins-Aff32" data-author-search="Goggins, Michael">Michael Goggins</a><sup class="u-js-hide"><a href="#Aff32">32</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Carlos_A-Gonz_lez-Aff33" data-author-popup="auth-Carlos_A-Gonz_lez-Aff33" data-author-search="González, Carlos A">Carlos A González</a><sup class="u-js-hide"><a href="#Aff33">33</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-G_ran-Hallmans-Aff34" data-author-popup="auth-G_ran-Hallmans-Aff34" data-author-search="Hallmans, Göran">Göran Hallmans</a><sup class="u-js-hide"><a href="#Aff34">34</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Susan_E-Hankinson-Aff3-Aff6" data-author-popup="auth-Susan_E-Hankinson-Aff3-Aff6" data-author-search="Hankinson, Susan E">Susan E Hankinson</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff6">6</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Manal-Hassan-Aff35" data-author-popup="auth-Manal-Hassan-Aff35" data-author-search="Hassan, Manal">Manal Hassan</a><sup class="u-js-hide"><a href="#Aff35">35</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Elizabeth_A-Holly-Aff22" data-author-popup="auth-Elizabeth_A-Holly-Aff22" data-author-search="Holly, Elizabeth A">Elizabeth A Holly</a><sup class="u-js-hide"><a href="#Aff22">22</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-David_J-Hunter-Aff3-Aff6" data-author-popup="auth-David_J-Hunter-Aff3-Aff6" data-author-search="Hunter, David J">David J Hunter</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff6">6</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Amy-Hutchinson-Aff2-Aff36" data-author-popup="auth-Amy-Hutchinson-Aff2-Aff36" data-author-search="Hutchinson, Amy">Amy Hutchinson</a><sup class="u-js-hide"><a href="#Aff2">2</a>,<a href="#Aff36">36</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Rebecca-Jackson-Aff37" data-author-popup="auth-Rebecca-Jackson-Aff37" data-author-search="Jackson, Rebecca">Rebecca Jackson</a><sup class="u-js-hide"><a href="#Aff37">37</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Kevin_B-Jacobs-Aff2-Aff36-Aff38" data-author-popup="auth-Kevin_B-Jacobs-Aff2-Aff36-Aff38" data-author-search="Jacobs, Kevin B">Kevin B Jacobs</a><sup class="u-js-hide"><a href="#Aff2">2</a>,<a href="#Aff36">36</a>,<a href="#Aff38">38</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Mazda-Jenab-Aff27" data-author-popup="auth-Mazda-Jenab-Aff27" data-author-search="Jenab, Mazda">Mazda Jenab</a><sup class="u-js-hide"><a href="#Aff27">27</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Rudolf-Kaaks-Aff23" data-author-popup="auth-Rudolf-Kaaks-Aff23" data-author-search="Kaaks, Rudolf">Rudolf Kaaks</a><sup class="u-js-hide"><a href="#Aff23">23</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Alison_P-Klein-Aff39-Aff40" data-author-popup="auth-Alison_P-Klein-Aff39-Aff40" data-author-search="Klein, Alison P">Alison P Klein</a><sup class="u-js-hide"><a href="#Aff39">39</a>,<a href="#Aff40">40</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Charles-Kooperberg-Aff15" data-author-popup="auth-Charles-Kooperberg-Aff15" data-author-search="Kooperberg, Charles">Charles Kooperberg</a><sup class="u-js-hide"><a href="#Aff15">15</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Robert_C-Kurtz-Aff41" data-author-popup="auth-Robert_C-Kurtz-Aff41" data-author-search="Kurtz, Robert C">Robert C Kurtz</a><sup class="u-js-hide"><a href="#Aff41">41</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Donghui-Li-Aff35" data-author-popup="auth-Donghui-Li-Aff35" data-author-search="Li, Donghui">Donghui Li</a><sup class="u-js-hide"><a href="#Aff35">35</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Shannon_M-Lynch-Aff42" data-author-popup="auth-Shannon_M-Lynch-Aff42" data-author-search="Lynch, Shannon M">Shannon M Lynch</a><sup class="u-js-hide"><a href="#Aff42">42</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Margaret-Mandelson-Aff15-Aff43" data-author-popup="auth-Margaret-Mandelson-Aff15-Aff43" data-author-search="Mandelson, Margaret">Margaret Mandelson</a><sup class="u-js-hide"><a href="#Aff15">15</a>,<a href="#Aff43">43</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Robert_R-McWilliams-Aff44" data-author-popup="auth-Robert_R-McWilliams-Aff44" data-author-search="McWilliams, Robert R">Robert R McWilliams</a><sup class="u-js-hide"><a href="#Aff44">44</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Julie_B-Mendelsohn-Aff2" data-author-popup="auth-Julie_B-Mendelsohn-Aff2" data-author-search="Mendelsohn, Julie B">Julie B Mendelsohn</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Dominique_S-Michaud-Aff3-Aff45" data-author-popup="auth-Dominique_S-Michaud-Aff3-Aff45" data-author-search="Michaud, Dominique S">Dominique S Michaud</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff45">45</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Sara_H-Olson-Aff46" data-author-popup="auth-Sara_H-Olson-Aff46" data-author-search="Olson, Sara H">Sara H Olson</a><sup class="u-js-hide"><a href="#Aff46">46</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Kim-Overvad-Aff47" data-author-popup="auth-Kim-Overvad-Aff47" data-author-search="Overvad, Kim">Kim Overvad</a><sup class="u-js-hide"><a href="#Aff47">47</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Alpa_V-Patel-Aff14" data-author-popup="auth-Alpa_V-Patel-Aff14" data-author-search="Patel, Alpa V">Alpa V Patel</a><sup class="u-js-hide"><a href="#Aff14">14</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Petra_H_M-Peeters-Aff45-Aff48" data-author-popup="auth-Petra_H_M-Peeters-Aff45-Aff48" data-author-search="Peeters, Petra H M">Petra H M Peeters</a><sup class="u-js-hide"><a href="#Aff45">45</a>,<a href="#Aff48">48</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Aleksandar-Rajkovic-Aff49" data-author-popup="auth-Aleksandar-Rajkovic-Aff49" data-author-search="Rajkovic, Aleksandar">Aleksandar Rajkovic</a><sup class="u-js-hide"><a href="#Aff49">49</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Elio-Riboli-Aff45" data-author-popup="auth-Elio-Riboli-Aff45" data-author-search="Riboli, Elio">Elio Riboli</a><sup class="u-js-hide"><a href="#Aff45">45</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Harvey_A-Risch-Aff50" data-author-popup="auth-Harvey_A-Risch-Aff50" data-author-search="Risch, Harvey A">Harvey A Risch</a><sup class="u-js-hide"><a href="#Aff50">50</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Xiao_Ou-Shu-Aff16" data-author-popup="auth-Xiao_Ou-Shu-Aff16" data-author-search="Shu, Xiao-Ou">Xiao-Ou Shu</a><sup class="u-js-hide"><a href="#Aff16">16</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Gilles-Thomas-Aff2" data-author-popup="auth-Gilles-Thomas-Aff2" data-author-search="Thomas, Gilles">Gilles Thomas</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Geoffrey_S-Tobias-Aff2" data-author-popup="auth-Geoffrey_S-Tobias-Aff2" data-author-search="Tobias, Geoffrey S">Geoffrey S Tobias</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Dimitrios-Trichopoulos-Aff3-Aff51" data-author-popup="auth-Dimitrios-Trichopoulos-Aff3-Aff51" data-author-search="Trichopoulos, Dimitrios">Dimitrios Trichopoulos</a><sup class="u-js-hide"><a href="#Aff3">3</a>,<a href="#Aff51">51</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Stephen_K-Van_Den_Eeden-Aff52" data-author-popup="auth-Stephen_K-Van_Den_Eeden-Aff52" data-author-search="Van Den Eeden, Stephen K">Stephen K Van Den Eeden</a><sup class="u-js-hide"><a href="#Aff52">52</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Jarmo-Virtamo-Aff53" data-author-popup="auth-Jarmo-Virtamo-Aff53" data-author-search="Virtamo, Jarmo">Jarmo Virtamo</a><sup class="u-js-hide"><a href="#Aff53">53</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Jean-Wactawski_Wende-Aff54" data-author-popup="auth-Jean-Wactawski_Wende-Aff54" data-author-search="Wactawski-Wende, Jean">Jean Wactawski-Wende</a><sup class="u-js-hide"><a href="#Aff54">54</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Brian_M-Wolpin-Aff5-Aff6" data-author-popup="auth-Brian_M-Wolpin-Aff5-Aff6" data-author-search="Wolpin, Brian M">Brian M Wolpin</a><sup class="u-js-hide"><a href="#Aff5">5</a>,<a href="#Aff6">6</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Herbert-Yu-Aff50" data-author-popup="auth-Herbert-Yu-Aff50" data-author-search="Yu, Herbert">Herbert Yu</a><sup class="u-js-hide"><a href="#Aff50">50</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Kai-Yu-Aff2" data-author-popup="auth-Kai-Yu-Aff2" data-author-search="Yu, Kai">Kai Yu</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Anne-Zeleniuch_Jacquotte-Aff9-Aff10" data-author-popup="auth-Anne-Zeleniuch_Jacquotte-Aff9-Aff10" data-author-search="Zeleniuch-Jacquotte, Anne">Anne Zeleniuch-Jacquotte</a><sup class="u-js-hide"><a href="#Aff9">9</a>,<a href="#Aff10">10</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Stephen_J-Chanock-Aff1-Aff2" data-author-popup="auth-Stephen_J-Chanock-Aff1-Aff2" data-author-search="Chanock, Stephen J" data-corresp-id="c1">Stephen J Chanock<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a>,<a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#na1">na1</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Patricia-Hartge-Aff2" data-author-popup="auth-Patricia-Hartge-Aff2" data-author-search="Hartge, Patricia">Patricia Hartge</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#na1">na1</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 71 authors for this article" title="Show all 71 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Robert_N-Hoover-Aff2" data-author-popup="auth-Robert_N-Hoover-Aff2" data-author-search="Hoover, Robert N">Robert N Hoover</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#na1">na1</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <p class="c-article-info-details" data-container-section="info"> <a data-test="journal-link" href="/ng" data-track="click" data-track-action="journal homepage" data-track-category="article body" data-track-label="link"><i data-test="journal-title">Nature Genetics</i></a> <b data-test="journal-volume"><span class="u-visually-hidden">volume</span> 41</b>, <span class="u-visually-hidden">pages </span>986–990 (<span data-test="article-publication-year">2009</span>)<a href="#citeas" class="c-article-info-details__cite-as u-hide-print" data-track="click" data-track-action="cite this article" data-track-label="link">Cite this article</a> </p> <div class="c-article-metrics-bar__wrapper u-clear-both"> <ul class="c-article-metrics-bar u-list-reset"> <li class=" c-article-metrics-bar__item" data-test="access-count"> <p class="c-article-metrics-bar__count">3832 <span class="c-article-metrics-bar__label">Accesses</span></p> </li> <li class="c-article-metrics-bar__item" data-test="altmetric-score"> <p class="c-article-metrics-bar__count">68 <span class="c-article-metrics-bar__label">Altmetric</span></p> </li> <li class="c-article-metrics-bar__item"> <p class="c-article-metrics-bar__details"><a href="/articles/ng.429/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Metrics <span class="u-visually-hidden">details</span></a></p> </li> </ul> </div> </header> </div> <div class="c-article-body"> <section aria-labelledby="Abs2" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs2-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs2">Abstract</h2><div class="c-article-section__content" id="Abs2-content"><p>We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined <i>P</i> = 5.37 × 10<sup>−8</sup>; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12–1.28). This SNP maps to the first intron of the <i>ABO</i> blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.</p></div></div></section> <noscript> <div class="c-nature-box c-nature-box--side " data-component="entitlement-box"> <div class="js-access-button"> <a href="https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fng.429" class="c-article__button" data-test="ra21"> <svg class="u-icon" width="18" height="18" aria-hidden="true" focusable="false"><use href="#icon-institution"></use></svg> <span class="c-article__button-text">Access through your institution</span> </a> </div> <div class="js-buy-button"> <a href="#access-options" class="c-article__button c-article__button--inverted" data-test="ra21"> <span>Buy or subscribe</span> </a> </div> </div> </noscript> <div class="js-context-bar-sticky-point-mobile" data-track-context="article body"> </div> <div class="c-article-access-provider 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Cancer statistics, 2008. <i>CA Cancer J. Clin.</i> <b>58</b>, 71–96 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.3322/CA.2007.0010" data-track-item_id="10.3322/CA.2007.0010" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.3322%2FCA.2007.0010" aria-label="Article reference 1" data-doi="10.3322/CA.2007.0010">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18287387" aria-label="PubMed reference 1">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 1" href="http://scholar.google.com/scholar_lookup?&title=Cancer%20statistics%2C%202008&journal=CA%20Cancer%20J.%20Clin.&doi=10.3322%2FCA.2007.0010&volume=58&pages=71-96&publication_year=2008&author=Jemal%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="2"><p class="c-article-references__text" id="ref-CR2">Ferlay, J., Bray, F., Pisani, P. & Parkin, D.M. GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide. <i>IARC CancerBase</i> <b>No. 5</b>, IARC<i>Press</i>, Lyon (2004).</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="3"><p class="c-article-references__text" id="ref-CR3">Anderson, K.E., Mack, T. & Silverman, D. Cancer of the pancreas. in <i>Cancer Epidemiology and Prevention</i> (ed. Schottenfeld, D. & Fraumeni, J.J.) (Oxford Univ. Press, New York, 2006).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 3" href="http://scholar.google.com/scholar_lookup?&title=Cancer%20of%20the%20pancreas&publication_year=2006&author=Anderson%2CKE&author=Mack%2CT&author=Silverman%2CD"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="4"><p class="c-article-references__text" id="ref-CR4">Lowenfels, A.B. et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. <i>J. Natl. Cancer Inst.</i> <b>89</b>, 442–446 (1997).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/jnci/89.6.442" data-track-item_id="10.1093/jnci/89.6.442" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Fjnci%2F89.6.442" aria-label="Article reference 4" data-doi="10.1093/jnci/89.6.442">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaK2s3ivVWhug%3D%3D" aria-label="CAS reference 4">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9091646" aria-label="PubMed reference 4">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 4" href="http://scholar.google.com/scholar_lookup?&title=Hereditary%20pancreatitis%20and%20the%20risk%20of%20pancreatic%20cancer.%20International%20Hereditary%20Pancreatitis%20Study%20Group&journal=J.%20Natl.%20Cancer%20Inst.&doi=10.1093%2Fjnci%2F89.6.442&volume=89&pages=442-446&publication_year=1997&author=Lowenfels%2CAB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="5"><p class="c-article-references__text" id="ref-CR5">Castleman, B. Case records of the Massachusetts General Hospital. <i>N. Engl. J. Med.</i> <b>286</b>, 1353–1359 (1972).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1056/NEJM197206222862510" data-track-item_id="10.1056/NEJM197206222862510" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1056%2FNEJM197206222862510" aria-label="Article reference 5" data-doi="10.1056/NEJM197206222862510">Article</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 5" href="http://scholar.google.com/scholar_lookup?&title=Case%20records%20of%20the%20Massachusetts%20General%20Hospital&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJM197206222862510&volume=286&pages=1353-1359&publication_year=1972&author=Castleman%2CB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="6"><p class="c-article-references__text" id="ref-CR6">Klein, A.P. et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. <i>Cancer Res.</i> <b>64</b>, 2634–2638 (2004).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1158/0008-5472.CAN-03-3823" data-track-item_id="10.1158/0008-5472.CAN-03-3823" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1158%2F0008-5472.CAN-03-3823" aria-label="Article reference 6" data-doi="10.1158/0008-5472.CAN-03-3823">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2cXis1yju7s%3D" aria-label="CAS reference 6">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15059921" aria-label="PubMed reference 6">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 6" href="http://scholar.google.com/scholar_lookup?&title=Prospective%20risk%20of%20pancreatic%20cancer%20in%20familial%20pancreatic%20cancer%20kindreds&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-03-3823&volume=64&pages=2634-2638&publication_year=2004&author=Klein%2CAP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="7"><p class="c-article-references__text" id="ref-CR7">Calle, E.E. et al. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. <i>Cancer</i> <b>94</b>, 2490–2501 (2002).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/cncr.101970" data-track-item_id="10.1002/cncr.101970" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fcncr.101970" aria-label="Article reference 7" data-doi="10.1002/cncr.101970">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12015775" aria-label="PubMed reference 7">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 7" href="http://scholar.google.com/scholar_lookup?&title=The%20American%20Cancer%20Society%20Cancer%20Prevention%20Study%20II%20Nutrition%20Cohort%3A%20rationale%2C%20study%20design%2C%20and%20baseline%20characteristics&journal=Cancer&doi=10.1002%2Fcncr.101970&volume=94&pages=2490-2501&publication_year=2002&author=Calle%2CEE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="8"><p class="c-article-references__text" id="ref-CR8">The ATBC Cancer Prevention Study Group. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. <i>Ann. Epidemiol.</i> <b>4</b>, 1–10 (1994).</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="9"><p class="c-article-references__text" id="ref-CR9">Riboli, E. et al. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. <i>Public Health Nutr.</i> <b>5</b>, 1113–1124 (2002).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1079/PHN2002394" data-track-item_id="10.1079/PHN2002394" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1079%2FPHN2002394" aria-label="Article reference 9" data-doi="10.1079/PHN2002394">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3s7is1Ohsw%3D%3D" aria-label="CAS reference 9">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12639222" aria-label="PubMed reference 9">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 9" href="http://scholar.google.com/scholar_lookup?&title=European%20Prospective%20Investigation%20into%20Cancer%20and%20Nutrition%20%28EPIC%29%3A%20study%20populations%20and%20data%20collection&journal=Public%20Health%20Nutr.&doi=10.1079%2FPHN2002394&volume=5&pages=1113-1124&publication_year=2002&author=Riboli%2CE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="10"><p class="c-article-references__text" id="ref-CR10">Gallicchio, L. et al. Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland. <i>Am. J. Epidemiol.</i> <b>167</b>, 807–813 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/aje/kwm378" data-track-item_id="10.1093/aje/kwm378" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Faje%2Fkwm378" aria-label="Article reference 10" data-doi="10.1093/aje/kwm378">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18263601" aria-label="PubMed reference 10">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 10" href="http://scholar.google.com/scholar_lookup?&title=Single%20nucleotide%20polymorphisms%20in%20inflammation-related%20genes%20and%20mortality%20in%20a%20community-based%20cohort%20in%20Washington%20County%2C%20Maryland&journal=Am.%20J.%20Epidemiol.&doi=10.1093%2Faje%2Fkwm378&volume=167&pages=807-813&publication_year=2008&author=Gallicchio%2CL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="11"><p class="c-article-references__text" id="ref-CR11">Wolpin, B.M. et al. Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. <i>Cancer Res.</i> <b>67</b>, 7923–7928 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1158/0008-5472.CAN-07-0373" data-track-item_id="10.1158/0008-5472.CAN-07-0373" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1158%2F0008-5472.CAN-07-0373" aria-label="Article reference 11" data-doi="10.1158/0008-5472.CAN-07-0373">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2sXptVGltL4%3D" aria-label="CAS reference 11">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17699799" aria-label="PubMed reference 11">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 11" href="http://scholar.google.com/scholar_lookup?&title=Circulating%20insulin-like%20growth%20factor%20binding%20protein-1%20and%20the%20risk%20of%20pancreatic%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-07-0373&volume=67&pages=7923-7928&publication_year=2007&author=Wolpin%2CBM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="12"><p class="c-article-references__text" id="ref-CR12">Zeleniuch-Jacquotte, A. et al. Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: results of a prospective study. <i>Int. J. Cancer</i> <b>114</b>, 323–327 (2005).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/ijc.20694" data-track-item_id="10.1002/ijc.20694" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fijc.20694" aria-label="Article reference 12" data-doi="10.1002/ijc.20694">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2MXhtFOksLo%3D" aria-label="CAS reference 12">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15540225" aria-label="PubMed reference 12">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 12" href="http://scholar.google.com/scholar_lookup?&title=Postmenopausal%20levels%20of%20sex%20hormones%20and%20risk%20of%20breast%20carcinoma%20in%20situ%3A%20results%20of%20a%20prospective%20study&journal=Int.%20J.%20Cancer&doi=10.1002%2Fijc.20694&volume=114&pages=323-327&publication_year=2005&author=Zeleniuch-Jacquotte%2CA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="13"><p class="c-article-references__text" id="ref-CR13">Hayes, R.B. et al. Methods for etiologic and early marker investigations in the PLCO trial. <i>Mutat. Res.</i> <b>592</b>, 147–154 (2005).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.mrfmmm.2005.06.013" data-track-item_id="10.1016/j.mrfmmm.2005.06.013" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.mrfmmm.2005.06.013" aria-label="Article reference 13" data-doi="10.1016/j.mrfmmm.2005.06.013">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2MXht1OmsLzN" aria-label="CAS reference 13">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16054167" aria-label="PubMed reference 13">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 13" href="http://scholar.google.com/scholar_lookup?&title=Methods%20for%20etiologic%20and%20early%20marker%20investigations%20in%20the%20PLCO%20trial&journal=Mutat.%20Res.&doi=10.1016%2Fj.mrfmmm.2005.06.013&volume=592&pages=147-154&publication_year=2005&author=Hayes%2CRB"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="14"><p class="c-article-references__text" id="ref-CR14">Xu, W.H. et al. Joint effect of cigarette smoking and alcohol consumption on mortality. <i>Prev. Med.</i> <b>45</b>, 313–319 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ypmed.2007.05.015" data-track-item_id="10.1016/j.ypmed.2007.05.015" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ypmed.2007.05.015" aria-label="Article reference 14" data-doi="10.1016/j.ypmed.2007.05.015">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17628652" aria-label="PubMed reference 14">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997335" aria-label="PubMed Central reference 14">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 14" href="http://scholar.google.com/scholar_lookup?&title=Joint%20effect%20of%20cigarette%20smoking%20and%20alcohol%20consumption%20on%20mortality&journal=Prev.%20Med.&doi=10.1016%2Fj.ypmed.2007.05.015&volume=45&pages=313-319&publication_year=2007&author=Xu%2CWH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="15"><p class="c-article-references__text" id="ref-CR15">Zheng, W. et al. The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. <i>Am. J. Epidemiol.</i> <b>162</b>, 1123–1131 (2005).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/aje/kwi322" data-track-item_id="10.1093/aje/kwi322" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Faje%2Fkwi322" aria-label="Article reference 15" data-doi="10.1093/aje/kwi322">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16236996" aria-label="PubMed reference 15">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 15" href="http://scholar.google.com/scholar_lookup?&title=The%20Shanghai%20Women%27s%20Health%20Study%3A%20rationale%2C%20study%20design%2C%20and%20baseline%20characteristics&journal=Am.%20J.%20Epidemiol.&doi=10.1093%2Faje%2Fkwi322&volume=162&pages=1123-1131&publication_year=2005&author=Zheng%2CW"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="16"><p class="c-article-references__text" id="ref-CR16">Anderson, G.L. et al. Implementation of the Women's Health Initiative study design. <i>Ann. Epidemiol.</i> <b>13</b>, S5–S17 (2003).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/S1047-2797(03)00043-7" data-track-item_id="10.1016/S1047-2797(03)00043-7" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2FS1047-2797%2803%2900043-7" aria-label="Article reference 16" data-doi="10.1016/S1047-2797(03)00043-7">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14575938" aria-label="PubMed reference 16">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 16" href="http://scholar.google.com/scholar_lookup?&title=Implementation%20of%20the%20Women%27s%20Health%20Initiative%20study%20design&journal=Ann.%20Epidemiol.&doi=10.1016%2FS1047-2797%2803%2900043-7&volume=13&pages=S5-S17&publication_year=2003&author=Anderson%2CGL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="17"><p class="c-article-references__text" id="ref-CR17">Rexrode, K.M., Lee, I.M., Cook, N.R., Hennekens, C.H. & Buring, J.E. Baseline characteristics of participants in the Women's Health Study. <i>J. Womens Health Gend. Based Med.</i> <b>9</b>, 19–27 (2000).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1089/152460900318911" data-track-item_id="10.1089/152460900318911" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1089%2F152460900318911" aria-label="Article reference 17" data-doi="10.1089/152460900318911">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3c7otFChuw%3D%3D" aria-label="CAS reference 17">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10718501" aria-label="PubMed reference 17">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 17" href="http://scholar.google.com/scholar_lookup?&title=Baseline%20characteristics%20of%20participants%20in%20the%20Women%27s%20Health%20Study&journal=J.%20Womens%20Health%20Gend.%20Based%20Med.&doi=10.1089%2F152460900318911&volume=9&pages=19-27&publication_year=2000&author=Rexrode%2CKM&author=Lee%2CIM&author=Cook%2CNR&author=Hennekens%2CCH&author=Buring%2CJE"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="18"><p class="c-article-references__text" id="ref-CR18">McWilliams, R.R. et al. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. <i>Cancer Res.</i> <b>68</b>, 4928–4935 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1158/0008-5472.CAN-07-5539" data-track-item_id="10.1158/0008-5472.CAN-07-5539" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1158%2F0008-5472.CAN-07-5539" aria-label="Article reference 18" data-doi="10.1158/0008-5472.CAN-07-5539">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXnt1ejt70%3D" aria-label="CAS reference 18">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18544627" aria-label="PubMed reference 18">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652067" aria-label="PubMed Central reference 18">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 18" href="http://scholar.google.com/scholar_lookup?&title=Polymorphisms%20in%20DNA%20repair%20genes%2C%20smoking%2C%20and%20pancreatic%20adenocarcinoma%20risk&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-07-5539&volume=68&pages=4928-4935&publication_year=2008&author=McWilliams%2CRR"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="19"><p class="c-article-references__text" id="ref-CR19">Eppel, A., Cotterchio, M. & Gallinger, S. Allergies are associated with reduced pancreas cancer risk: A population-based case-control study in Ontario, Canada. <i>Int. J. Cancer</i> <b>121</b>, 2241–2245 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/ijc.22884" data-track-item_id="10.1002/ijc.22884" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fijc.22884" aria-label="Article reference 19" data-doi="10.1002/ijc.22884">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2sXht1aisL7F" aria-label="CAS reference 19">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17582608" aria-label="PubMed reference 19">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 19" href="http://scholar.google.com/scholar_lookup?&title=Allergies%20are%20associated%20with%20reduced%20pancreas%20cancer%20risk%3A%20A%20population-based%20case-control%20study%20in%20Ontario%2C%20Canada&journal=Int.%20J.%20Cancer&doi=10.1002%2Fijc.22884&volume=121&pages=2241-2245&publication_year=2007&author=Eppel%2CA&author=Cotterchio%2CM&author=Gallinger%2CS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="20"><p class="c-article-references__text" id="ref-CR20">Duell, E.J. et al. Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. <i>Cancer Epidemiol. Biomarkers Prev.</i> <b>17</b>, 1470–1479 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1158/1055-9965.EPI-07-2797" data-track-item_id="10.1158/1055-9965.EPI-07-2797" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1158%2F1055-9965.EPI-07-2797" aria-label="Article reference 20" data-doi="10.1158/1055-9965.EPI-07-2797">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXnsVKgtbs%3D" aria-label="CAS reference 20">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18559563" aria-label="PubMed reference 20">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410856" aria-label="PubMed Central reference 20">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 20" href="http://scholar.google.com/scholar_lookup?&title=Detecting%20pathway-based%20gene-gene%20and%20gene-environment%20interactions%20in%20pancreatic%20cancer&journal=Cancer%20Epidemiol.%20Biomarkers%20Prev.&doi=10.1158%2F1055-9965.EPI-07-2797&volume=17&pages=1470-1479&publication_year=2008&author=Duell%2CEJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="21"><p class="c-article-references__text" id="ref-CR21">Hassan, M.M. et al. Risk factors for pancreatic cancer: case-control study. <i>Am. J. Gastroenterol.</i> <b>102</b>, 2696–2707 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1111/j.1572-0241.2007.01510.x" data-track-item_id="10.1111/j.1572-0241.2007.01510.x" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1111%2Fj.1572-0241.2007.01510.x" aria-label="Article reference 21" data-doi="10.1111/j.1572-0241.2007.01510.x">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17764494" aria-label="PubMed reference 21">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423805" aria-label="PubMed Central reference 21">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 21" href="http://scholar.google.com/scholar_lookup?&title=Risk%20factors%20for%20pancreatic%20cancer%3A%20case-control%20study&journal=Am.%20J.%20Gastroenterol.&doi=10.1111%2Fj.1572-0241.2007.01510.x&volume=102&pages=2696-2707&publication_year=2007&author=Hassan%2CMM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="22"><p class="c-article-references__text" id="ref-CR22">Olson, S.H. et al. Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer. <i>Cancer Detect. Prev.</i> <b>31</b>, 345–351 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.cdp.2007.10.002" data-track-item_id="10.1016/j.cdp.2007.10.002" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.cdp.2007.10.002" aria-label="Article reference 22" data-doi="10.1016/j.cdp.2007.10.002">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXhslKrsLg%3D" aria-label="CAS reference 22">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18031948" aria-label="PubMed reference 22">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 22" href="http://scholar.google.com/scholar_lookup?&title=Allergies%2C%20variants%20in%20IL-4%20and%20IL-4R%20alpha%20genes%2C%20and%20risk%20of%20pancreatic%20cancer&journal=Cancer%20Detect.%20Prev.&doi=10.1016%2Fj.cdp.2007.10.002&volume=31&pages=345-351&publication_year=2007&author=Olson%2CSH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="23"><p class="c-article-references__text" id="ref-CR23">Risch, H.A. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. <i>J. Natl. Cancer Inst.</i> <b>95</b>, 948–960 (2003).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/jnci/95.13.948" data-track-item_id="10.1093/jnci/95.13.948" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Fjnci%2F95.13.948" aria-label="Article reference 23" data-doi="10.1093/jnci/95.13.948">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD3sXltFygtLg%3D" aria-label="CAS reference 23">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12837831" aria-label="PubMed reference 23">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 23" href="http://scholar.google.com/scholar_lookup?&title=Etiology%20of%20pancreatic%20cancer%2C%20with%20a%20hypothesis%20concerning%20the%20role%20of%20N-nitroso%20compounds%20and%20excess%20gastric%20acidity&journal=J.%20Natl.%20Cancer%20Inst.&doi=10.1093%2Fjnci%2F95.13.948&volume=95&pages=948-960&publication_year=2003&author=Risch%2CHA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="24"><p class="c-article-references__text" id="ref-CR24">Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. <i>Nat. Genet.</i> <b>38</b>, 209–213 (2006).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/ng1706" data-track-item_id="10.1038/ng1706" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fng1706" aria-label="Article reference 24" data-doi="10.1038/ng1706">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD28XotlGlsg%3D%3D" aria-label="CAS reference 24">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16415888" aria-label="PubMed reference 24">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 24" href="http://scholar.google.com/scholar_lookup?&title=Joint%20analysis%20is%20more%20efficient%20than%20replication-based%20analysis%20for%20two-stage%20genome-wide%20association%20studies&journal=Nat.%20Genet.&doi=10.1038%2Fng1706&volume=38&pages=209-213&publication_year=2006&author=Skol%2CAD&author=Scott%2CLJ&author=Abecasis%2CGR&author=Boehnke%2CM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="25"><p class="c-article-references__text" id="ref-CR25">Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. <i>Nature</i> <b>447</b>, 661–678 (2007).</p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="26"><p class="c-article-references__text" id="ref-CR26">Aird, I., Bentall, H.H. & Roberts, J.A. A relationship between cancer of stomach and the ABO blood groups. <i>BMJ</i> <b>1</b>, 799–801 (1953).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1136/bmj.1.4814.799" data-track-item_id="10.1136/bmj.1.4814.799" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1136%2Fbmj.1.4814.799" aria-label="Article reference 26" data-doi="10.1136/bmj.1.4814.799">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaG3s%2Flslajsw%3D%3D" aria-label="CAS reference 26">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=13032504" aria-label="PubMed reference 26">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2015995" aria-label="PubMed Central reference 26">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 26" href="http://scholar.google.com/scholar_lookup?&title=A%20relationship%20between%20cancer%20of%20stomach%20and%20the%20ABO%20blood%20groups&journal=BMJ&doi=10.1136%2Fbmj.1.4814.799&volume=1&pages=799-801&publication_year=1953&author=Aird%2CI&author=Bentall%2CHH&author=Roberts%2CJA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="27"><p class="c-article-references__text" id="ref-CR27">Marcus, D.M. The ABO and Lewis blood-group system. Immunochemistry, genetics and relation to human disease. <i>N. Engl. J. Med.</i> <b>280</b>, 994–1006 (1969).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1056/NEJM196905012801806" data-track-item_id="10.1056/NEJM196905012801806" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1056%2FNEJM196905012801806" aria-label="Article reference 27" data-doi="10.1056/NEJM196905012801806">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaF1M7lslGgsg%3D%3D" aria-label="CAS reference 27">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=4888078" aria-label="PubMed reference 27">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 27" href="http://scholar.google.com/scholar_lookup?&title=The%20ABO%20and%20Lewis%20blood-group%20system.%20Immunochemistry%2C%20genetics%20and%20relation%20to%20human%20disease&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJM196905012801806&volume=280&pages=994-1006&publication_year=1969&author=Marcus%2CDM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="28"><p class="c-article-references__text" id="ref-CR28">Melzer, D. et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). <i>PLoS Genet.</i> <b>4</b>, e1000072 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1371/journal.pgen.1000072" data-track-item_id="10.1371/journal.pgen.1000072" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1371%2Fjournal.pgen.1000072" aria-label="Article reference 28" data-doi="10.1371/journal.pgen.1000072">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464913" aria-label="PubMed reference 28">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362067" aria-label="PubMed Central reference 28">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 28" href="http://scholar.google.com/scholar_lookup?&title=A%20genome-wide%20association%20study%20identifies%20protein%20quantitative%20trait%20loci%20%28pQTLs%29&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1000072&volume=4&publication_year=2008&author=Melzer%2CD"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="29"><p class="c-article-references__text" id="ref-CR29">Paré, G. et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. <i>PLoS Genet.</i> <b>4</b>, e1000118 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1371/journal.pgen.1000118" data-track-item_id="10.1371/journal.pgen.1000118" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1371%2Fjournal.pgen.1000118" aria-label="Article reference 29" data-doi="10.1371/journal.pgen.1000118">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18604267" aria-label="PubMed reference 29">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432033" aria-label="PubMed Central reference 29">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 29" href="http://scholar.google.com/scholar_lookup?&title=Novel%20association%20of%20ABO%20histo-blood%20group%20antigen%20with%20soluble%20ICAM-1%3A%20results%20of%20a%20genome-wide%20association%20study%20of%206%2C578%20women&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1000118&volume=4&publication_year=2008&author=Par%C3%A9%2CG"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="30"><p class="c-article-references__text" id="ref-CR30">Yuan, X. et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. <i>Am. J. Hum. Genet.</i> <b>83</b>, 520–528 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1016/j.ajhg.2008.09.012" data-track-item_id="10.1016/j.ajhg.2008.09.012" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1016%2Fj.ajhg.2008.09.012" aria-label="Article reference 30" data-doi="10.1016/j.ajhg.2008.09.012">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXht1OmtbrM" aria-label="CAS reference 30">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18940312" aria-label="PubMed reference 30">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561937" aria-label="PubMed Central reference 30">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 30" href="http://scholar.google.com/scholar_lookup?&title=Population-based%20genome-wide%20association%20studies%20reveal%20six%20loci%20influencing%20plasma%20levels%20of%20liver%20enzymes&journal=Am.%20J.%20Hum.%20Genet.&doi=10.1016%2Fj.ajhg.2008.09.012&volume=83&pages=520-528&publication_year=2008&author=Yuan%2CX"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="31"><p class="c-article-references__text" id="ref-CR31">Itzkowitz, S.H. et al. Cancer-associated alterations of blood group antigen expression in the human pancreas. <i>J. Natl. Cancer Inst.</i> <b>79</b>, 425–434 (1987).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DyaL2szht1Ohsg%3D%3D" aria-label="CAS reference 31">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2442445" aria-label="PubMed reference 31">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 31" href="http://scholar.google.com/scholar_lookup?&title=Cancer-associated%20alterations%20of%20blood%20group%20antigen%20expression%20in%20the%20human%20pancreas&journal=J.%20Natl.%20Cancer%20Inst.&volume=79&pages=425-434&publication_year=1987&author=Itzkowitz%2CSH"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="32"><p class="c-article-references__text" id="ref-CR32">Berman, D.M. et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. <i>Nature</i> <b>425</b>, 846–851 (2003).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/nature01972" data-track-item_id="10.1038/nature01972" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fnature01972" aria-label="Article reference 32" data-doi="10.1038/nature01972">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD3sXotlWqsLc%3D" aria-label="CAS reference 32">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14520411" aria-label="PubMed reference 32">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 32" href="http://scholar.google.com/scholar_lookup?&title=Widespread%20requirement%20for%20Hedgehog%20ligand%20stimulation%20in%20growth%20of%20digestive%20tract%20tumours&journal=Nature&doi=10.1038%2Fnature01972&volume=425&pages=846-851&publication_year=2003&author=Berman%2CDM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="33"><p class="c-article-references__text" id="ref-CR33">Wolpin, B.M. et al. ABO blood group and the risk of pancreatic cancer. <i>J. Natl. Cancer Inst.</i> <b>101</b>, 424–431 (2009).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1093/jnci/djp020" data-track-item_id="10.1093/jnci/djp020" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1093%2Fjnci%2Fdjp020" aria-label="Article reference 33" data-doi="10.1093/jnci/djp020">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1MXjsFCjtr4%3D" aria-label="CAS reference 33">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19276450" aria-label="PubMed reference 33">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657095" aria-label="PubMed Central reference 33">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 33" href="http://scholar.google.com/scholar_lookup?&title=ABO%20blood%20group%20and%20the%20risk%20of%20pancreatic%20cancer&journal=J.%20Natl.%20Cancer%20Inst.&doi=10.1093%2Fjnci%2Fdjp020&volume=101&pages=424-431&publication_year=2009&author=Wolpin%2CBM"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="34"><p class="c-article-references__text" id="ref-CR34">Wigginton, J.E., Cutler, D.J. & Abecasis, G.R. A note on exact tests of Hardy-Weinberg equilibrium. <i>Am. J. Hum. Genet.</i> <b>76</b>, 887–893 (2005).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1086/429864" data-track-item_id="10.1086/429864" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1086%2F429864" aria-label="Article reference 34" data-doi="10.1086/429864">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2MXjs12rtLY%3D" aria-label="CAS reference 34">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15789306" aria-label="PubMed reference 34">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199378" aria-label="PubMed Central reference 34">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 34" href="http://scholar.google.com/scholar_lookup?&title=A%20note%20on%20exact%20tests%20of%20Hardy-Weinberg%20equilibrium&journal=Am.%20J.%20Hum.%20Genet.&doi=10.1086%2F429864&volume=76&pages=887-893&publication_year=2005&author=Wigginton%2CJE&author=Cutler%2CDJ&author=Abecasis%2CGR"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="35"><p class="c-article-references__text" id="ref-CR35">Pritchard, J.K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. <i>Genetics</i> <b>155</b>, 945–959 (2000).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:STN:280:DC%2BD3cvislKrtA%3D%3D" aria-label="CAS reference 35">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10835412" aria-label="PubMed reference 35">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461096" aria-label="PubMed Central reference 35">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 35" href="http://scholar.google.com/scholar_lookup?&title=Inference%20of%20population%20structure%20using%20multilocus%20genotype%20data&journal=Genetics&volume=155&pages=945-959&publication_year=2000&author=Pritchard%2CJK&author=Stephens%2CM&author=Donnelly%2CP"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="36"><p class="c-article-references__text" id="ref-CR36">Frazer, K.A. et al. A second generation human haplotype map of over 3.1 million SNPs. <i>Nature</i> <b>449</b>, 851–861 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/nature06258" data-track-item_id="10.1038/nature06258" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fnature06258" aria-label="Article reference 36" data-doi="10.1038/nature06258">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2sXhtFOjt7jL" aria-label="CAS reference 36">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17943122" aria-label="PubMed reference 36">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 36" href="http://scholar.google.com/scholar_lookup?&title=A%20second%20generation%20human%20haplotype%20map%20of%20over%203.1%20million%20SNPs&journal=Nature&doi=10.1038%2Fnature06258&volume=449&pages=851-861&publication_year=2007&author=Frazer%2CKA"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="37"><p class="c-article-references__text" id="ref-CR37">Thomas, G. et al. Multiple loci identified in a genome-wide association study of prostate cancer. <i>Nat. Genet.</i> <b>40</b>, 310–315 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/ng.91" data-track-item_id="10.1038/ng.91" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fng.91" aria-label="Article reference 37" data-doi="10.1038/ng.91">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD1cXisVKht78%3D" aria-label="CAS reference 37">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18264096" aria-label="PubMed reference 37">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 37" href="http://scholar.google.com/scholar_lookup?&title=Multiple%20loci%20identified%20in%20a%20genome-wide%20association%20study%20of%20prostate%20cancer&journal=Nat.%20Genet.&doi=10.1038%2Fng.91&volume=40&pages=310-315&publication_year=2008&author=Thomas%2CG"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="38"><p class="c-article-references__text" id="ref-CR38">Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. <i>Nat. Genet.</i> <b>39</b>, 870–874 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/ng2075" data-track-item_id="10.1038/ng2075" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fng2075" aria-label="Article reference 38" data-doi="10.1038/ng2075">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD2sXmvFKlsLg%3D" aria-label="CAS reference 38">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17529973" aria-label="PubMed reference 38">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493132" aria-label="PubMed Central reference 38">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 38" href="http://scholar.google.com/scholar_lookup?&title=A%20genome-wide%20association%20study%20identifies%20alleles%20in%20FGFR2%20associated%20with%20risk%20of%20sporadic%20postmenopausal%20breast%20cancer&journal=Nat.%20Genet.&doi=10.1038%2Fng2075&volume=39&pages=870-874&publication_year=2007&author=Hunter%2CDJ"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="39"><p class="c-article-references__text" id="ref-CR39">Yu, K. et al. Population substructure and control selection in genome-wide association studies. <i>PLoS One</i> <b>3</b>, e2551 (2008).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1371/journal.pone.0002551" data-track-item_id="10.1371/journal.pone.0002551" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1371%2Fjournal.pone.0002551" aria-label="Article reference 39" data-doi="10.1371/journal.pone.0002551">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18596976" aria-label="PubMed reference 39">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432498" aria-label="PubMed Central reference 39">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 39" href="http://scholar.google.com/scholar_lookup?&title=Population%20substructure%20and%20control%20selection%20in%20genome-wide%20association%20studies&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0002551&volume=3&publication_year=2008&author=Yu%2CK"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="40"><p class="c-article-references__text" id="ref-CR40">Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. <i>Nat. Genet.</i> <b>38</b>, 904–909 (2006).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1038/ng1847" data-track-item_id="10.1038/ng1847" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1038%2Fng1847" aria-label="Article reference 40" data-doi="10.1038/ng1847">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="cas reference" data-track-action="cas reference" href="/articles/cas-redirect/1:CAS:528:DC%2BD28XnsVCgsrg%3D" aria-label="CAS reference 40">CAS</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16862161" aria-label="PubMed reference 40">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 40" href="http://scholar.google.com/scholar_lookup?&title=Principal%20components%20analysis%20corrects%20for%20stratification%20in%20genome-wide%20association%20studies&journal=Nat.%20Genet.&doi=10.1038%2Fng1847&volume=38&pages=904-909&publication_year=2006&author=Price%2CAL"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="41"><p class="c-article-references__text" id="ref-CR41">Patterson, N., Price, A.L. & Reich, D. Population structure and eigenanalysis. <i>PLoS Genet.</i> <b>2</b>, e190 (2006).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1371/journal.pgen.0020190" data-track-item_id="10.1371/journal.pgen.0020190" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1371%2Fjournal.pgen.0020190" aria-label="Article reference 41" data-doi="10.1371/journal.pgen.0020190">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17194218" aria-label="PubMed reference 41">PubMed</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed central reference" data-track-action="pubmed central reference" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1713260" aria-label="PubMed Central reference 41">PubMed Central</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 41" href="http://scholar.google.com/scholar_lookup?&title=Population%20structure%20and%20eigenanalysis&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0020190&volume=2&publication_year=2006&author=Patterson%2CN&author=Price%2CAL&author=Reich%2CD"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="42"><p class="c-article-references__text" id="ref-CR42">Sun, L., Wilder, K. & McPeek, M.S. Enhanced pedigree error detection. <i>Hum. Hered.</i> <b>54</b>, 99–110 (2002).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1159/000067666" data-track-item_id="10.1159/000067666" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1159%2F000067666" aria-label="Article reference 42" data-doi="10.1159/000067666">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12566741" aria-label="PubMed reference 42">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 42" href="http://scholar.google.com/scholar_lookup?&title=Enhanced%20pedigree%20error%20detection&journal=Hum.%20Hered.&doi=10.1159%2F000067666&volume=54&pages=99-110&publication_year=2002&author=Sun%2CL&author=Wilder%2CK&author=McPeek%2CMS"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="43"><p class="c-article-references__text" id="ref-CR43">Lettre, G., Lange, C. & Hirschhorn, J.N. Genetic model testing and statistical power in population-based association studies of quantitative traits. <i>Genet. Epidemiol.</i> <b>31</b>, 358–362 (2007).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/gepi.20217" data-track-item_id="10.1002/gepi.20217" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fgepi.20217" aria-label="Article reference 43" data-doi="10.1002/gepi.20217">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17352422" aria-label="PubMed reference 43">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 43" href="http://scholar.google.com/scholar_lookup?&title=Genetic%20model%20testing%20and%20statistical%20power%20in%20population-based%20association%20studies%20of%20quantitative%20traits&journal=Genet.%20Epidemiol.&doi=10.1002%2Fgepi.20217&volume=31&pages=358-362&publication_year=2007&author=Lettre%2CG&author=Lange%2CC&author=Hirschhorn%2CJN"> Google Scholar</a> </p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="44"><p class="c-article-references__text" id="ref-CR44">Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. <i>Stat. Med.</i> <b>21</b>, 1539–1558 (2002).</p><p class="c-article-references__links u-hide-print"><a data-track="click_references" rel="nofollow noopener" data-track-label="10.1002/sim.1186" data-track-item_id="10.1002/sim.1186" data-track-value="article reference" data-track-action="article reference" href="https://doi.org/10.1002%2Fsim.1186" aria-label="Article reference 44" data-doi="10.1002/sim.1186">Article</a> <a data-track="click_references" rel="nofollow noopener" data-track-label="link" data-track-item_id="link" data-track-value="pubmed reference" data-track-action="pubmed reference" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12111919" aria-label="PubMed reference 44">PubMed</a> <a data-track="click_references" data-track-action="google scholar reference" data-track-value="google scholar reference" data-track-label="link" data-track-item_id="link" rel="nofollow noopener" aria-label="Google Scholar reference 44" href="http://scholar.google.com/scholar_lookup?&title=Quantifying%20heterogeneity%20in%20a%20meta-analysis&journal=Stat.%20Med.&doi=10.1002%2Fsim.1186&volume=21&pages=1539-1558&publication_year=2002&author=Higgins%2CJP&author=Thompson%2CSG"> Google Scholar</a> </p></li></ol><p class="c-article-references__download u-hide-print"><a data-track="click" data-track-action="download citation references" data-track-label="link" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1038/ng.429?format=refman&flavour=references">Download references<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p></div></div></div></section></div><section data-title="Acknowledgements"><div class="c-article-section" id="Ack1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Ack1">Acknowledgements</h2><div class="c-article-section__content" id="Ack1-content"><p>The authors gratefully acknowledge the energy and contribution of our late colleague, Robert Welch. Additional acknowledgments are found in the <a data-track="click" data-track-label="link" data-track-action="supplementary material anchor" href="/articles/ng.429#MOESM12">Supplementary Note</a>.</p></div></div></section><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><span class="c-article-author-information__subtitle u-visually-hidden" id="author-notes">Author notes</span><ol class="c-article-author-information__list"><li class="c-article-author-information__item" id="na1"><p>Laufey Amundadottir, Peter Kraft, Rachael Z Stolzenberg-Solomon, Charles S Fuchs, Stephen J Chanock, Patricia Hartge and Robert N Hoover: These authors contributed equally to this work.</p></li></ol><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Laufey Amundadottir & Stephen J Chanock</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Laufey Amundadottir, Rachael Z Stolzenberg-Solomon, Demetrius Albanes, Amy Hutchinson, Kevin B Jacobs, Julie B Mendelsohn, Gilles Thomas, Geoffrey S Tobias, Kai Yu, Stephen J Chanock, Patricia Hartge & Robert N Hoover</p></li><li id="Aff3"><p class="c-article-author-affiliation__address">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Peter Kraft, Edward L Giovannucci, Susan E Hankinson, David J Hunter, Dominique S Michaud & Dimitrios Trichopoulos</p></li><li id="Aff4"><p class="c-article-author-affiliation__address">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Peter Kraft</p></li><li id="Aff5"><p class="c-article-author-affiliation__address">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Charles S Fuchs & Brian M Wolpin</p></li><li id="Aff6"><p class="c-article-author-affiliation__address">Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Charles S Fuchs, Edward L Giovannucci, Susan E Hankinson, David J Hunter & Brian M Wolpin</p></li><li id="Aff7"><p class="c-article-author-affiliation__address">Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</p><p class="c-article-author-affiliation__authors-list">Gloria M Petersen, William Bamlet & Mariza de Andrade</p></li><li id="Aff8"><p class="c-article-author-affiliation__address">Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA</p><p class="c-article-author-affiliation__authors-list">Alan A Arslan</p></li><li id="Aff9"><p class="c-article-author-affiliation__address">Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA</p><p class="c-article-author-affiliation__authors-list">Alan A Arslan & Anne Zeleniuch-Jacquotte</p></li><li id="Aff10"><p class="c-article-author-affiliation__address">New York University Cancer Institute, New York, New York, USA</p><p class="c-article-author-affiliation__authors-list">Alan A Arslan & Anne Zeleniuch-Jacquotte</p></li><li id="Aff11"><p class="c-article-author-affiliation__address">and Department of Gastroenterology and Hepatology, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, University Medical Center Utrecht, Utrecht, The Netherlands</p><p class="c-article-author-affiliation__authors-list">H Bas Bueno-de-Mesquita</p></li><li id="Aff12"><p class="c-article-author-affiliation__address">Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA</p><p class="c-article-author-affiliation__authors-list">Myron Gross</p></li><li id="Aff13"><p class="c-article-author-affiliation__address">Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Kathy Helzlsouer</p></li><li id="Aff14"><p class="c-article-author-affiliation__address">Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA</p><p class="c-article-author-affiliation__authors-list">Eric J Jacobs & Alpa V Patel</p></li><li id="Aff15"><p class="c-article-author-affiliation__address">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</p><p class="c-article-author-affiliation__authors-list">Andrea LaCroix, Charles Kooperberg & Margaret Mandelson</p></li><li id="Aff16"><p class="c-article-author-affiliation__address">Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA</p><p class="c-article-author-affiliation__authors-list">Wei Zheng & Xiao-Ou Shu</p></li><li id="Aff17"><p class="c-article-author-affiliation__address">Division of Cancer Prevention, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Christine D Berg</p></li><li id="Aff18"><p class="c-article-author-affiliation__address">Etiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy</p><p class="c-article-author-affiliation__authors-list">Franco Berrino</p></li><li id="Aff19"><p class="c-article-author-affiliation__address">MRC Dunn Human Nutrition Unit, University of Cambridge, Cambridge, UK</p><p class="c-article-author-affiliation__authors-list">Sheila Bingham</p></li><li id="Aff20"><p class="c-article-author-affiliation__address">Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Julie E Buring</p></li><li id="Aff21"><p class="c-article-author-affiliation__address">Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Julie E Buring</p></li><li id="Aff22"><p class="c-article-author-affiliation__address">Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California, USA</p><p class="c-article-author-affiliation__authors-list">Paige M Bracci & Elizabeth A Holly</p></li><li id="Aff23"><p class="c-article-author-affiliation__address">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</p><p class="c-article-author-affiliation__authors-list">Federico Canzian & Rudolf Kaaks</p></li><li id="Aff24"><p class="c-article-author-affiliation__address">Institut National de la Santé et de la Recherche Médicale (INSERM) and Institut Gustave Roussy, Villejuif, France</p><p class="c-article-author-affiliation__authors-list">Françoise Clavel-Chapelon</p></li><li id="Aff25"><p class="c-article-author-affiliation__address">The Johns Hopkins Bloomberg School of Public Health, George W. Comstock Center for Public Health Research and Prevention, Hagerstown, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Sandra Clipp</p></li><li id="Aff26"><p class="c-article-author-affiliation__address">Cancer Care Ontario and Dalla Lana School of Public Health, University of Toronto, Ontario, Canada</p><p class="c-article-author-affiliation__authors-list">Michelle Cotterchio</p></li><li id="Aff27"><p class="c-article-author-affiliation__address">International Agency for Research on Cancer, Lyon, France</p><p class="c-article-author-affiliation__authors-list">Eric J Duell & Mazda Jenab</p></li><li id="Aff28"><p class="c-article-author-affiliation__address">College of Human Medicine, Michigan State University, East Lansing, Michigan, USA</p><p class="c-article-author-affiliation__authors-list">John W Fox Jr</p></li><li id="Aff29"><p class="c-article-author-affiliation__address">Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</p><p class="c-article-author-affiliation__authors-list">Steven Gallinger</p></li><li id="Aff30"><p class="c-article-author-affiliation__address">Divisions of Aging, Department of Medicine, Physicians' Health Study, Cardiovascular Medicine and Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA, and Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">J Michael Gaziano</p></li><li id="Aff31"><p class="c-article-author-affiliation__address">Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</p><p class="c-article-author-affiliation__authors-list">Edward L Giovannucci</p></li><li id="Aff32"><p class="c-article-author-affiliation__address">Departments of Oncology, Pathology and Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Michael Goggins</p></li><li id="Aff33"><p class="c-article-author-affiliation__address">Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain</p><p class="c-article-author-affiliation__authors-list">Carlos A González</p></li><li id="Aff34"><p class="c-article-author-affiliation__address">Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden</p><p class="c-article-author-affiliation__authors-list">Göran Hallmans</p></li><li id="Aff35"><p class="c-article-author-affiliation__address">Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</p><p class="c-article-author-affiliation__authors-list">Manal Hassan & Donghui Li</p></li><li id="Aff36"><p class="c-article-author-affiliation__address">Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Amy Hutchinson & Kevin B Jacobs</p></li><li id="Aff37"><p class="c-article-author-affiliation__address">Division of Endocrinology, Department of Internal Medicine and Center for Clinical and Translational Science, Diabetes and Metabolism, Ohio State University, Columbus, Ohio, USA</p><p class="c-article-author-affiliation__authors-list">Rebecca Jackson</p></li><li id="Aff38"><p class="c-article-author-affiliation__address">Bioinformed, LLC, Gaithersburg, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Kevin B Jacobs</p></li><li id="Aff39"><p class="c-article-author-affiliation__address">Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Alison P Klein</p></li><li id="Aff40"><p class="c-article-author-affiliation__address">Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Sol Goldman Pancreatic Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Alison P Klein</p></li><li id="Aff41"><p class="c-article-author-affiliation__address">Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</p><p class="c-article-author-affiliation__authors-list">Robert C Kurtz</p></li><li id="Aff42"><p class="c-article-author-affiliation__address">Division of Cancer Control and Population Sciences, Department of Health and Human Services, Epidemiology and Genetics Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</p><p class="c-article-author-affiliation__authors-list">Shannon M Lynch</p></li><li id="Aff43"><p class="c-article-author-affiliation__address">Group Health Center for Health Studies, Seattle, Washington, USA</p><p class="c-article-author-affiliation__authors-list">Margaret Mandelson</p></li><li id="Aff44"><p class="c-article-author-affiliation__address">Department of Oncology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</p><p class="c-article-author-affiliation__authors-list">Robert R McWilliams</p></li><li id="Aff45"><p class="c-article-author-affiliation__address">Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK</p><p class="c-article-author-affiliation__authors-list">Dominique S Michaud, Petra H M Peeters & Elio Riboli</p></li><li id="Aff46"><p class="c-article-author-affiliation__address">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</p><p class="c-article-author-affiliation__authors-list">Sara H Olson</p></li><li id="Aff47"><p class="c-article-author-affiliation__address">Department of Cardiology and Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark</p><p class="c-article-author-affiliation__authors-list">Kim Overvad</p></li><li id="Aff48"><p class="c-article-author-affiliation__address">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands</p><p class="c-article-author-affiliation__authors-list">Petra H M Peeters</p></li><li id="Aff49"><p class="c-article-author-affiliation__address">Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA</p><p class="c-article-author-affiliation__authors-list">Aleksandar Rajkovic</p></li><li id="Aff50"><p class="c-article-author-affiliation__address">Yale University School of Public Health, New Haven, Connecticut, USA</p><p class="c-article-author-affiliation__authors-list">Harvey A Risch & Herbert Yu</p></li><li id="Aff51"><p class="c-article-author-affiliation__address">Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece</p><p class="c-article-author-affiliation__authors-list">Dimitrios Trichopoulos</p></li><li id="Aff52"><p class="c-article-author-affiliation__address">Division of Research, Kaiser Permanente, Northern California Region, Oakland, California, USA</p><p class="c-article-author-affiliation__authors-list">Stephen K Van Den Eeden</p></li><li id="Aff53"><p class="c-article-author-affiliation__address">Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland</p><p class="c-article-author-affiliation__authors-list">Jarmo Virtamo</p></li><li id="Aff54"><p class="c-article-author-affiliation__address">Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA</p><p class="c-article-author-affiliation__authors-list">Jean Wactawski-Wende</p></li></ol><div 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L.A., A.H., K.B.J., G.T. and S.J.C. supervised genotyping of samples. L.A., P.K., R.Z.S.-S., C.S.F., K.B.J., C.K., K.Y., S.J.C., P.H. and R.N.H. contributed to the design and execution of statistical analysis. LA., S.J.C., P.H. and R.N.H. wrote the first draft of the manuscript. R.Z.S.-S., C.S.F., G.M.P., A.A.A., H.B.B.-d.-M., M.G., K.H., E.J.J., A.L., W.Z., D.A., W.B., C.D.B., F.B., S.B., J.E.B., P.M.B., F.C., F.C.-C., S.C., M.C., M.d.A., E.J.D., J.W.F., S.G., J.M.G., E.L.G., M.G., C.A.G., G.H., S.E.H., M.H., E.A.H., D.J.H., R.J., M.J., R.K., A.P.K., C.K., R.C.K., D.L., M.M., R.R.M., D.S.M., S.H.O., K.O., A.V.P., P.H.M.P., A.R., E.R., H.A.R., X.-O.S., D.T., S.K.V.D.E., J.V., J.W.-W., B.M.W., H.Y. and A.Z.-J. conducted the epidemiologic studies and contributed samples to the PanScan GWAS and/or replication. All authors contributed to the writing of the manuscript.</p><h3 class="c-article__sub-heading" id="corresponding-author">Corresponding author</h3><p id="corresponding-author-list">Correspondence to <a id="corresp-c1" href="mailto:chanocks@mail.nih.gov">Stephen J Chanock</a>.</p></div></div></section><section data-title="Supplementary information"><div class="c-article-section" id="Sec8-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec8">Supplementary information</h2><div class="c-article-section__content" id="Sec8-content"><div data-test="supplementary-info"><div id="figshareContainer" class="c-article-figshare-container" data-test="figshare-container"></div><div class="c-article-supplementary__item" data-test="supp-item" id="MOESM12"><h3 class="c-article-supplementary__title u-h3"><a class="print-link" data-track="click" data-track-action="view supplementary info" data-test="supp-info-link" data-track-label="supplementary text 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class="c-bibliographic-information__citation">Amundadottir, L., Kraft, P., Stolzenberg-Solomon, R. <i>et al.</i> Genome-wide association study identifies variants in the <i>ABO</i> locus associated with susceptibility to pancreatic cancer. <i>Nat Genet</i> <b>41</b>, 986–990 (2009). https://doi.org/10.1038/ng.429</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1038/ng.429?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul class="c-bibliographic-information__list" data-test="publication-history"><li 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Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer | Nature Genetics