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data-track="click" data-track-action="view article" data-track-label="link">Estimating uncertainty in reference-based cell type annotation in single-cell genomics</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>PopV is an ensemble method for cell type labeling in single-cell genomics. A Cell Ontology-inspired voting procedure across different algorithms highlights low confidence annotations, thereby guiding human-in-the loop components of the annotation process.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research Briefing</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-26" itemprop="datePublished">26 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-02018-9/MediaObjects/41588_2024_2018_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02018-9/MediaObjects/41588_2024_2018_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02018-9/MediaObjects/41588_2024_2018_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-02018-9" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Copy number alterations in normal breast tissues revealed by single-cell whole-genome sequencing</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Using single-cell whole-genome sequencing, we reveal the landscape of copy number alterations in normal breast tissue from both <i>BRCA</i> carriers and wild-type individuals.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research Briefing</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-26" itemprop="datePublished">26 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-01980-8/MediaObjects/41588_2024_1980_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01980-8/MediaObjects/41588_2024_1980_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01980-8/MediaObjects/41588_2024_1980_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-01980-8" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Split-pool barcoding serves up an epigenomic smorgasbord</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Perez, Goronzy et al. present ChIP-DIP, which enables multiplex genomic mapping of hundreds of epitopes from a single sample. 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class="c-meta__type">Turning Points</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-22" itemprop="datePublished">22 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-02016-x/MediaObjects/41588_2024_2016_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02016-x/MediaObjects/41588_2024_2016_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02016-x/MediaObjects/41588_2024_2016_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-02016-x" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Elucidating the genomic basis of rare pediatric neurological diseases in Central Asia and Transcaucasia</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rauan Kaiyrzhanov</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Nazira Zharkinbekova</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Henry Houlden</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Correspondence</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-22" itemprop="datePublished">22 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-01961-x/MediaObjects/41588_2024_1961_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01961-x/MediaObjects/41588_2024_1961_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01961-x/MediaObjects/41588_2024_1961_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-01961-x" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Spatial and single-nucleus analyses in human postmortem Alzheimer’s disease (AD) brain tissues at early and late stages from individuals with and without Down syndrome, as well as in AD mouse models, show sex and species-specific phenotypic changes.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Emily Miyoshi</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Samuel Morabito</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Vivek Swarup</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Article</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-22" itemprop="datePublished">22 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-01952-y/MediaObjects/41588_2024_1952_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01952-y/MediaObjects/41588_2024_1952_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01952-y/MediaObjects/41588_2024_1952_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-01952-y" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sean L. Zheng</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Albert Henry</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">R. Thomas Lumbers</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Article</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-21" itemprop="datePublished">21 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-01975-5/MediaObjects/41588_2024_1975_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01975-5/MediaObjects/41588_2024_1975_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01975-5/MediaObjects/41588_2024_1975_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-01975-5" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Genome-wide association and multitrait analyses for dilated cardiomyopathy (DCM) using 9,365 cases and 946,368 controls provide insights into the mechanisms underlying DCM and myocardial resilience</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sean J. Jurgens</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Joel T. Rämö</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Connie R. Bezzina</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Letter</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-21" itemprop="datePublished">21 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-02034-9" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Author Correction: <i>Brca1</i> haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Carman Man-Chung Li</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Alyssa Cordes</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Joan S. Brugge</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Author Correction</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-20" itemprop="datePublished">20 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-02021-0/MediaObjects/41588_2024_2021_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02021-0/MediaObjects/41588_2024_2021_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-02021-0/MediaObjects/41588_2024_2021_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-02021-0" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Epigenetic scars of <i>Brca1</i> loss point toward breast cancer cell of origin</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as <i>BRCA1</i>. However, a study now shows that the loss of just one <i>Brca1</i> allele in mice can pre-program cells for cancer-promoting changes, indicating cancer may progress earlier than previously thought.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Steven M. 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Remarkably, activation of JAK/STAT signaling is essential in regulating expansion and differentiation of Basal-B-like cells during prostate inflammation, identifying this signaling pathway as a potential therapeutic target in prostatitis associated with increased Basal-B signature.</p> </div> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research Briefing</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-15" itemprop="datePublished">15 Nov 2024</time> </div> </article> </div> </li> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41588-024-01979-1/MediaObjects/41588_2024_1979_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01979-1/MediaObjects/41588_2024_1979_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41588-024-01979-1/MediaObjects/41588_2024_1979_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41588-024-01979-1" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>This study identifies Basal-B cells as a transient cell state during prostate homeostasis and androgen-mediated regeneration. These cells exist in humans and increase in number with prostatitis and inflammation.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Wangxin Guo</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiaoyu Zhang</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Dong Gao</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Article</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-13" itemprop="datePublished">13 Nov 2024</time> </div> </article> </div> </li> </ul> </div> </section> <div class="u-container u-mb-48"> <nav class="u-display-flex u-justify-content-center u-mt-24 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