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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Heart Failure</h1><div class="u-tcGrayDark">16,468 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Heart Failure</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Heart_Failure">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Heart_Failure/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Heart_Failure/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Heart_Failure/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Heart_Failure">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25869807" data-work_id="25869807" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25869807/Renal_Hemodynamic_Changes_in_Heart_Failure">Renal Hemodynamic Changes in Heart Failure</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25869807" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="73381e965cd5686508f6e911c3d35953" rel="nofollow" data-download="{"attachment_id":46235752,"asset_id":25869807,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46235752/download_file?st=MTczOTgwNzY0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49622094" href="https://independent.academia.edu/GeorgeBakris">George Bakris</a><script data-card-contents-for-user="49622094" type="text/json">{"id":49622094,"first_name":"George","last_name":"Bakris","domain_name":"independent","page_name":"GeorgeBakris","display_name":"George Bakris","profile_url":"https://independent.academia.edu/GeorgeBakris?f_ri=49633","photo":"https://0.academia-photos.com/49622094/64740880/53066914/s65_george.bakris.jpeg"}</script></span></span></li><li class="js-paper-rank-work_25869807 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25869807"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25869807, container: ".js-paper-rank-work_25869807", }); 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The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6082696" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The acute hemodynamic efficacy of an implantable counter-pulsation device (CPD) was evaluated. The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple surface surgical procedure. Blood is drawn into the pump during systole and ejected during diastole. The acute hemodynamic effects of the 32-ml CPD were compared to a standard clinical 40-ml intra-aortic balloon pump (IABP) in calves (80 kg, n = 10). The calves were treated by a single oral dose of Monensin to produce a model of diminished cardiac function (DCF). The CPD and IABP produced similar increases in cardiac output (6% CPD vs. 5% IABP, p > 0.5) and reduction in left ventricular external work (14% CPD vs. 13% IABP, p > 0.5) compared to DCF (p < 0.05). However, the ratio of diastolic coronary artery flow to left ventricular external work increase from DCF baseline (p < 0.05) was greater with the CPD compared to the IABP (15% vs. 4%, p < 0.05). The CPD also produced a greater reduction in left ventricular myocardial oxygen consumption from DCF baseline (p < 0.05) compared to the IABP (13% vs. 9%, p < 0.05) despite each device providing similar improvements in cardiac output. There was no early indication of hemolysis, thrombus formation, or vascular injury. The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6082696" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="36bebd58d67812b5d39022b4c5f1a8b3" rel="nofollow" data-download="{"attachment_id":49026229,"asset_id":6082696,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49026229/download_file?st=MTczOTgwNzY0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="9165011" href="https://louisville.academia.edu/MarkSSlaughter">Mark S. 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The CPD is a valveless single port, 32-ml stroke volume blood chamber designed to be connected to the human axillary artery using a simple surface surgical procedure. Blood is drawn into the pump during systole and ejected during diastole. The acute hemodynamic effects of the 32-ml CPD were compared to a standard clinical 40-ml intra-aortic balloon pump (IABP) in calves (80 kg, n = 10). The calves were treated by a single oral dose of Monensin to produce a model of diminished cardiac function (DCF). The CPD and IABP produced similar increases in cardiac output (6% CPD vs. 5% IABP, p \u003e 0.5) and reduction in left ventricular external work (14% CPD vs. 13% IABP, p \u003e 0.5) compared to DCF (p \u003c 0.05). However, the ratio of diastolic coronary artery flow to left ventricular external work increase from DCF baseline (p \u003c 0.05) was greater with the CPD compared to the IABP (15% vs. 4%, p \u003c 0.05). The CPD also produced a greater reduction in left ventricular myocardial oxygen consumption from DCF baseline (p \u003c 0.05) compared to the IABP (13% vs. 9%, p \u003c 0.05) despite each device providing similar improvements in cardiac output. There was no early indication of hemolysis, thrombus formation, or vascular injury. The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation.","downloadable_attachments":[{"id":49026229,"asset_id":6082696,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":9165011,"first_name":"Mark S.","last_name":"Slaughter","domain_name":"louisville","page_name":"MarkSSlaughter","display_name":"Mark S. Slaughter","profile_url":"https://louisville.academia.edu/MarkSSlaughter?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=49633","nofollow":true},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle?f_ri=49633","nofollow":true},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=49633"},{"id":426578,"name":"Cardiac Output Monitoring","url":"https://www.academia.edu/Documents/in/Cardiac_Output_Monitoring?f_ri=49633"},{"id":1005544,"name":"Continuous Flow Heart Assist Devices","url":"https://www.academia.edu/Documents/in/Continuous_Flow_Heart_Assist_Devices?f_ri=49633"},{"id":1145520,"name":"Equipment Design","url":"https://www.academia.edu/Documents/in/Equipment_Design?f_ri=49633"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=49633"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption?f_ri=49633"},{"id":2481953,"name":"Cardiac function","url":"https://www.academia.edu/Documents/in/Cardiac_function?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18439505" data-work_id="18439505" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18439505/Dopamine_receptors%C3%A2_physiological_understanding_to_therapeutic_intervention_potential">Dopamine receptorsâphysiological understanding to therapeutic intervention potential</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There are two families of dopamine (DA) receptors, called D1 and D2, respectively. The D1 family consists of D1- and D5-receptor subtypes and the D2 family consists of D2-, D3-, and D4-receptor subtypes. The amino acid sequences of these... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18439505" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There are two families of dopamine (DA) receptors, called D1 and D2, respectively. The D1 family consists of D1- and D5-receptor subtypes and the D2 family consists of D2-, D3-, and D4-receptor subtypes. The amino acid sequences of these receptors show that they all belong to a large superfamily of receptors with seven transmembrane domains, which are coupled to their</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18439505" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6f5fb0389e81d86c9cfc0739052dc040" rel="nofollow" data-download="{"attachment_id":42169120,"asset_id":18439505,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42169120/download_file?st=MTczOTgwNzY0NSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38447597" href="https://independent.academia.edu/JeanmarieMaloteaux">Jean-marie Maloteaux</a><script data-card-contents-for-user="38447597" type="text/json">{"id":38447597,"first_name":"Jean-marie","last_name":"Maloteaux","domain_name":"independent","page_name":"JeanmarieMaloteaux","display_name":"Jean-marie Maloteaux","profile_url":"https://independent.academia.edu/JeanmarieMaloteaux?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18439505 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18439505"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18439505, container: ".js-paper-rank-work_18439505", }); 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$(".js-view-count[data-work-id=18439505]").text(description); $(".js-view-count-work_18439505").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18439505").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18439505"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51566" rel="nofollow" href="https://www.academia.edu/Documents/in/Dopamine">Dopamine</a>, <script data-card-contents-for-ri="51566" type="text/json">{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="58378" rel="nofollow" href="https://www.academia.edu/Documents/in/Acute_renal_failure">Acute renal failure</a><script data-card-contents-for-ri="58378" type="text/json">{"id":58378,"name":"Acute renal failure","url":"https://www.academia.edu/Documents/in/Acute_renal_failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18439505]'), work: {"id":18439505,"title":"Dopamine receptorsâphysiological understanding to therapeutic intervention potential","created_at":"2015-11-16T06:11:09.010-08:00","url":"https://www.academia.edu/18439505/Dopamine_receptors%C3%A2_physiological_understanding_to_therapeutic_intervention_potential?f_ri=49633","dom_id":"work_18439505","summary":"There are two families of dopamine (DA) receptors, called D1 and D2, respectively. The D1 family consists of D1- and D5-receptor subtypes and the D2 family consists of D2-, D3-, and D4-receptor subtypes. The amino acid sequences of these receptors show that they all belong to a large superfamily of receptors with seven transmembrane domains, which are coupled to their","downloadable_attachments":[{"id":42169120,"asset_id":18439505,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38447597,"first_name":"Jean-marie","last_name":"Maloteaux","domain_name":"independent","page_name":"JeanmarieMaloteaux","display_name":"Jean-marie Maloteaux","profile_url":"https://independent.academia.edu/JeanmarieMaloteaux?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=49633","nofollow":true},{"id":58378,"name":"Acute renal failure","url":"https://www.academia.edu/Documents/in/Acute_renal_failure?f_ri=49633","nofollow":true},{"id":72218,"name":"Vitamin D receptor","url":"https://www.academia.edu/Documents/in/Vitamin_D_receptor?f_ri=49633"},{"id":72821,"name":"Low Dose","url":"https://www.academia.edu/Documents/in/Low_Dose?f_ri=49633"},{"id":92680,"name":"cyclic AMP","url":"https://www.academia.edu/Documents/in/cyclic_AMP?f_ri=49633"},{"id":140065,"name":"dopamine receptor D4","url":"https://www.academia.edu/Documents/in/dopamine_receptor_D4?f_ri=49633"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function?f_ri=49633"},{"id":263029,"name":"Intensive Care Unit","url":"https://www.academia.edu/Documents/in/Intensive_Care_Unit?f_ri=49633"},{"id":278585,"name":"Tourette Syndrome","url":"https://www.academia.edu/Documents/in/Tourette_Syndrome?f_ri=49633"},{"id":429223,"name":"Dopamine Transporter","url":"https://www.academia.edu/Documents/in/Dopamine_Transporter?f_ri=49633"},{"id":565276,"name":"Toll-Like Receptors Therapeutics Pharmacology","url":"https://www.academia.edu/Documents/in/Toll-Like_Receptors_Therapeutics_Pharmacology?f_ri=49633"},{"id":780543,"name":"G protein","url":"https://www.academia.edu/Documents/in/G_protein?f_ri=49633"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=49633"},{"id":1180098,"name":"Renal disease","url":"https://www.academia.edu/Documents/in/Renal_disease?f_ri=49633"},{"id":1212380,"name":"Intracellular Signaling","url":"https://www.academia.edu/Documents/in/Intracellular_Signaling?f_ri=49633"},{"id":1275779,"name":"Drug Dependence","url":"https://www.academia.edu/Documents/in/Drug_Dependence?f_ri=49633"},{"id":2146132,"name":"Restless Leg Syndrome","url":"https://www.academia.edu/Documents/in/Restless_Leg_Syndrome?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14213397 coauthored" data-work_id="14213397" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14213397/Factors_associated_with_failure_to_rescue_in_patients_undergoing_trauma_laparotomy">Factors associated with failure-to-rescue in patients undergoing trauma laparotomy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction. Quality improvement initiatives have focused primarily on preventing in-hospital complications. Patients developing complications are at a greater risk of mortality; however, factors associated with failure-to-rescue (death... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14213397" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction. Quality improvement initiatives have focused primarily on preventing in-hospital complications. Patients developing complications are at a greater risk of mortality; however, factors associated with failure-to-rescue (death after major complication) in trauma patients remain undefined. The aim of this study was to identify risk factors associated with failure-to-rescue in patients undergoing trauma laparotomy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14213397" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e93b43bdd3b769d012d97f34660920d3" rel="nofollow" data-download="{"attachment_id":44459121,"asset_id":14213397,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44459121/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33199202" href="https://independent.academia.edu/TerenceOKeeffe">Terence O'Keeffe</a><script data-card-contents-for-user="33199202" type="text/json">{"id":33199202,"first_name":"Terence","last_name":"O'Keeffe","domain_name":"independent","page_name":"TerenceOKeeffe","display_name":"Terence O'Keeffe","profile_url":"https://independent.academia.edu/TerenceOKeeffe?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-14213397">+1</span><div class="hidden js-additional-users-14213397"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/PeterRhee">Peter Rhee</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-14213397'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-14213397').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14213397 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14213397"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14213397; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14213397]").text(description); $(".js-view-count-work_14213397").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14213397").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14213397"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="99698" rel="nofollow" href="https://www.academia.edu/Documents/in/Resuscitation">Resuscitation</a>, <script data-card-contents-for-ri="99698" type="text/json">{"id":99698,"name":"Resuscitation","url":"https://www.academia.edu/Documents/in/Resuscitation?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="109739" rel="nofollow" href="https://www.academia.edu/Documents/in/Infection">Infection</a><script data-card-contents-for-ri="109739" type="text/json">{"id":109739,"name":"Infection","url":"https://www.academia.edu/Documents/in/Infection?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14213397]'), work: {"id":14213397,"title":"Factors associated with failure-to-rescue in patients undergoing trauma laparotomy","created_at":"2015-07-20T09:39:34.203-07:00","url":"https://www.academia.edu/14213397/Factors_associated_with_failure_to_rescue_in_patients_undergoing_trauma_laparotomy?f_ri=49633","dom_id":"work_14213397","summary":"Introduction. Quality improvement initiatives have focused primarily on preventing in-hospital complications. Patients developing complications are at a greater risk of mortality; however, factors associated with failure-to-rescue (death after major complication) in trauma patients remain undefined. 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DESIGN: Randomized, controlled trial with follow-up through 52 weeks... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13328628" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">OBJECTIVES: To examine the effectiveness of a transitional care intervention delivered by advanced practice nurses (APNs) to elders hospitalized with heart failure. DESIGN: Randomized, controlled trial with follow-up through 52 weeks postindex hospital discharge. SETTING: Six Philadelphia academic and community hospitals. PARTICIPANTS: Two hundred thirty-nine eligible patients were aged 65 and older and hospitalized with heart failure. INTERVENTION: A 3-month APN-directed discharge planning and home follow-up protocol. MEASUREMENTS: Time to first rehospitalization or death, number of rehospitalizations, quality of life, functional status, costs, and satisfaction with care. RESULTS: Mean age of patients (control n 5 121; intervention n 5 118) enrolled was 76; 43% were male, and 36% were African American. Time to first readmission or death was longer in intervention patients (log rank w 2 5 5.0, P 5.026; Cox regression incidence density ratio 5 1.65, 95% confidence interval 5 1.13-2.40). At 52 weeks, intervention group patients had fewer readmissions (104 vs 162, P 5.047) and lower mean total costs ($7,636 vs $12,481, P 5.002). For intervention patients, only short-term improvements were demonstrated in overall quality of life (12 weeks, Po.05), physical dimension of quality of life (2 weeks, Po.01; 12 weeks, Po.05) and patient satisfaction (assessed at 2 and 6 weeks, Po.001).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13328628" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8c0592318af509cf8892b71af089bb93" rel="nofollow" data-download="{"attachment_id":45460915,"asset_id":13328628,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45460915/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32570289" href="https://upenn.academia.edu/GregMaislin">Greg Maislin</a><script data-card-contents-for-user="32570289" type="text/json">{"id":32570289,"first_name":"Greg","last_name":"Maislin","domain_name":"upenn","page_name":"GregMaislin","display_name":"Greg Maislin","profile_url":"https://upenn.academia.edu/GregMaislin?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13328628 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13328628"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13328628, container: ".js-paper-rank-work_13328628", }); 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DESIGN: Randomized, controlled trial with follow-up through 52 weeks postindex hospital discharge. SETTING: Six Philadelphia academic and community hospitals. PARTICIPANTS: Two hundred thirty-nine eligible patients were aged 65 and older and hospitalized with heart failure. INTERVENTION: A 3-month APN-directed discharge planning and home follow-up protocol. MEASUREMENTS: Time to first rehospitalization or death, number of rehospitalizations, quality of life, functional status, costs, and satisfaction with care. RESULTS: Mean age of patients (control n 5 121; intervention n 5 118) enrolled was 76; 43% were male, and 36% were African American. Time to first readmission or death was longer in intervention patients (log rank w 2 5 5.0, P 5.026; Cox regression incidence density ratio 5 1.65, 95% confidence interval 5 1.13-2.40). At 52 weeks, intervention group patients had fewer readmissions (104 vs 162, P 5.047) and lower mean total costs ($7,636 vs $12,481, P 5.002). For intervention patients, only short-term improvements were demonstrated in overall quality of life (12 weeks, Po.05), physical dimension of quality of life (2 weeks, Po.01; 12 weeks, Po.05) and patient satisfaction (assessed at 2 and 6 weeks, Po.001).","downloadable_attachments":[{"id":45460915,"asset_id":13328628,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32570289,"first_name":"Greg","last_name":"Maislin","domain_name":"upenn","page_name":"GregMaislin","display_name":"Greg Maislin","profile_url":"https://upenn.academia.edu/GregMaislin?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=49633","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=49633","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":68342,"name":"African American","url":"https://www.academia.edu/Documents/in/African_American?f_ri=49633"},{"id":75348,"name":"Cox Regression","url":"https://www.academia.edu/Documents/in/Cox_Regression?f_ri=49633"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=49633"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals?f_ri=49633"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":144052,"name":"Patient Satisfaction","url":"https://www.academia.edu/Documents/in/Patient_Satisfaction?f_ri=49633"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=49633"},{"id":194055,"name":"Randomised Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomised_Controlled_Trial?f_ri=49633"},{"id":233800,"name":"African Americans","url":"https://www.academia.edu/Documents/in/African_Americans?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":408219,"name":"Aftercare","url":"https://www.academia.edu/Documents/in/Aftercare?f_ri=49633"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=49633"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial?f_ri=49633"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group?f_ri=49633"},{"id":719793,"name":"Healthcare Costs","url":"https://www.academia.edu/Documents/in/Healthcare_Costs?f_ri=49633"},{"id":806178,"name":"Older Adult","url":"https://www.academia.edu/Documents/in/Older_Adult?f_ri=49633"},{"id":1034177,"name":"Continuity of Patient Care","url":"https://www.academia.edu/Documents/in/Continuity_of_Patient_Care?f_ri=49633"},{"id":1441309,"name":"Functional Status","url":"https://www.academia.edu/Documents/in/Functional_Status?f_ri=49633"},{"id":1524625,"name":"Home Care Services","url":"https://www.academia.edu/Documents/in/Home_Care_Services?f_ri=49633"},{"id":1587858,"name":"Confidence Interval","url":"https://www.academia.edu/Documents/in/Confidence_Interval?f_ri=49633"},{"id":2345130,"name":"Socioeconomic Factors","url":"https://www.academia.edu/Documents/in/Socioeconomic_Factors?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4609493" data-work_id="4609493" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4609493/Mitochondrial_potassium_transport_the_role_of_the_mitochondrial_ATP_sensitive_K_channel_in_cardiac_function_and_cardioprotection">Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K + channel in cardiac function and cardioprotection</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Coronary artery disease and its sequelae-ischemia, myocardial infarction, and heart failure-are leading causes of morbidity and mortality in man. Considerable effort has been devoted toward improving functional recovery and reducing the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4609493" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Coronary artery disease and its sequelae-ischemia, myocardial infarction, and heart failure-are leading causes of morbidity and mortality in man. Considerable effort has been devoted toward improving functional recovery and reducing the extent of infarction after ischemic episodes. As a step in this direction, it was found that the heart was significantly protected against ischemia -reperfusion injury if it was first preconditioned by brief ischemia or by administering a potassium channel opener. Both of these preconditioning strategies were found to require opening of a K ATP channel, and in 1997 we showed that this pivotal role was mediated by the mitochondrial ATP-sensitive K + channel (mitoK ATP ). This paper will review the evidence showing that opening mitoK ATP is cardioprotective against ischemiareperfusion injury and, moreover, that mitoK ATP plays this role during all three phases of the natural history of ischemia -reperfusion injury preconditioning, ischemia, and reperfusion. We discuss two distinct mechanisms by which mitoK ATP opening protects the heart-increased mitochondrial production of reactive oxygen species (ROS) during the preconditioning phase and regulation of intermembrane space (IMS) volume during the ischemic and reperfusion phases. It is likely that cardioprotection by ischemic preconditioning (IPC) and K ATP channel openers (KCOs) arises from utilization of normal physiological processes. Accordingly, we summarize the results of new studies that focus on the role of mitoK ATP in normal cardiomyocyte physiology. Here, we observe the same two mechanisms at work. In low-energy states, mitoK ATP opening triggers increased mitochondrial ROS production, thereby amplifying a cell signaling pathway leading to gene transcription and cell growth. In high-energy states, mitoK ATP opening prevents the matrix contraction that would otherwise occur during high rates of electron transport. MitoK ATP -mediated volume regulation, in turn, prevents disruption of the structure -function of the IMS and facilitates efficient energy transfers between mitochondria and myofibrillar ATPases. D</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4609493" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="078579ee1496a7775dbcc1634bb2b864" rel="nofollow" data-download="{"attachment_id":49756986,"asset_id":4609493,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49756986/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5803791" href="https://independent.academia.edu/AlexandreCosta5">Alexandre Costa</a><script data-card-contents-for-user="5803791" type="text/json">{"id":5803791,"first_name":"Alexandre","last_name":"Costa","domain_name":"independent","page_name":"AlexandreCosta5","display_name":"Alexandre Costa","profile_url":"https://independent.academia.edu/AlexandreCosta5?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_4609493 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4609493"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4609493, container: ".js-paper-rank-work_4609493", }); 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Considerable effort has been devoted toward improving functional recovery and reducing the extent of infarction after ischemic episodes. As a step in this direction, it was found that the heart was significantly protected against ischemia -reperfusion injury if it was first preconditioned by brief ischemia or by administering a potassium channel opener. Both of these preconditioning strategies were found to require opening of a K ATP channel, and in 1997 we showed that this pivotal role was mediated by the mitochondrial ATP-sensitive K + channel (mitoK ATP ). This paper will review the evidence showing that opening mitoK ATP is cardioprotective against ischemiareperfusion injury and, moreover, that mitoK ATP plays this role during all three phases of the natural history of ischemia -reperfusion injury preconditioning, ischemia, and reperfusion. We discuss two distinct mechanisms by which mitoK ATP opening protects the heart-increased mitochondrial production of reactive oxygen species (ROS) during the preconditioning phase and regulation of intermembrane space (IMS) volume during the ischemic and reperfusion phases. It is likely that cardioprotection by ischemic preconditioning (IPC) and K ATP channel openers (KCOs) arises from utilization of normal physiological processes. Accordingly, we summarize the results of new studies that focus on the role of mitoK ATP in normal cardiomyocyte physiology. Here, we observe the same two mechanisms at work. In low-energy states, mitoK ATP opening triggers increased mitochondrial ROS production, thereby amplifying a cell signaling pathway leading to gene transcription and cell growth. In high-energy states, mitoK ATP opening prevents the matrix contraction that would otherwise occur during high rates of electron transport. MitoK ATP -mediated volume regulation, in turn, prevents disruption of the structure -function of the IMS and facilitates efficient energy transfers between mitochondria and myofibrillar ATPases. D","downloadable_attachments":[{"id":49756986,"asset_id":4609493,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5803791,"first_name":"Alexandre","last_name":"Costa","domain_name":"independent","page_name":"AlexandreCosta5","display_name":"Alexandre Costa","profile_url":"https://independent.academia.edu/AlexandreCosta5?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9588,"name":"Natural History","url":"https://www.academia.edu/Documents/in/Natural_History?f_ri=49633","nofollow":true},{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins?f_ri=49633","nofollow":true},{"id":17856,"name":"Cell Signaling","url":"https://www.academia.edu/Documents/in/Cell_Signaling?f_ri=49633","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":50948,"name":"Ischemia Reperfusion Injury","url":"https://www.academia.edu/Documents/in/Ischemia_Reperfusion_Injury?f_ri=49633"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=49633"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences?f_ri=49633"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=49633"},{"id":132784,"name":"Low Energy Buildngs","url":"https://www.academia.edu/Documents/in/Low_Energy_Buildngs?f_ri=49633"},{"id":160656,"name":"Potassium","url":"https://www.academia.edu/Documents/in/Potassium?f_ri=49633"},{"id":186094,"name":"Electron Transport","url":"https://www.academia.edu/Documents/in/Electron_Transport?f_ri=49633"},{"id":400537,"name":"Functional Recovery","url":"https://www.academia.edu/Documents/in/Functional_Recovery?f_ri=49633"},{"id":557691,"name":"Potassium Channels","url":"https://www.academia.edu/Documents/in/Potassium_Channels?f_ri=49633"},{"id":717129,"name":"Energy Transfer","url":"https://www.academia.edu/Documents/in/Energy_Transfer?f_ri=49633"},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease?f_ri=49633"},{"id":1011864,"name":"Structure Function","url":"https://www.academia.edu/Documents/in/Structure_Function?f_ri=49633"},{"id":1499498,"name":"High energy","url":"https://www.academia.edu/Documents/in/High_energy?f_ri=49633"},{"id":1535956,"name":"Ischemic Preconditioning","url":"https://www.academia.edu/Documents/in/Ischemic_Preconditioning?f_ri=49633"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=49633"},{"id":1816594,"name":"Adenosine Triphosphate","url":"https://www.academia.edu/Documents/in/Adenosine_Triphosphate?f_ri=49633"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth?f_ri=49633"},{"id":2431818,"name":"Mitochondrion","url":"https://www.academia.edu/Documents/in/Mitochondrion?f_ri=49633"},{"id":2481953,"name":"Cardiac function","url":"https://www.academia.edu/Documents/in/Cardiac_function?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23281770" data-work_id="23281770" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23281770/Emerging_markers_of_cachexia_predict_survival_in_cancer_patients">Emerging markers of cachexia predict survival in cancer patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23281770" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. Methods: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. Results: Ghrelin levels were significantly higher in cancer patients than in healthy subjects (573.31 ± 130 vs 320.20 ± 66.48 ng/ml, p < 0.0001), while obestatin (17.42 ± 7.12 vs 24.89 ± 5.54 ng/ml, p < 0.0001) and leptin (38.4 ± 21.2 vs 76.28 ± 17.48 ng/ml, p < 0.0001) values were lower. At ROC analyses the diagnostic profile of ghrelin (AUC 0.962; sensitivity 83%; specificity 98%), obestatin (AUC 0.798; sensitivity 74.5%; specificity 81.5%) and leptin (AUC 0.828; sensitivity 79%; specificity 73%) was superior to that of albumin (AUC 0.547; sensitivity 63%, specificity 69.4%) for detecting cachexia among cancer patients. On Cox multivariate analyses ghrelin (HR 1.02; 95% CI 1.01 -1.03; p < 0.0001) and leptin (HR 0.94; 95% CI 0.92 -0.96; p < 0.0001) were significant predictors of death even after correction for other known risk factors such as presence of metastasis and chronic kidney disease. Conclusion: Ghrelin and leptin are promising biomarkers to diagnose cachexia and to predict survival in cancer patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23281770" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="afe7b50a472e52b5495d8f5f7891f47e" rel="nofollow" data-download="{"attachment_id":43751435,"asset_id":23281770,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43751435/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45162731" href="https://unime.academia.edu/SMondello">Stefania Mondello</a><script data-card-contents-for-user="45162731" type="text/json">{"id":45162731,"first_name":"Stefania","last_name":"Mondello","domain_name":"unime","page_name":"SMondello","display_name":"Stefania Mondello","profile_url":"https://unime.academia.edu/SMondello?f_ri=49633","photo":"https://0.academia-photos.com/45162731/28977264/27032638/s65_stefania.mondello.jpg"}</script></span></span></li><li class="js-paper-rank-work_23281770 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23281770"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23281770, container: ".js-paper-rank-work_23281770", }); });</script></li><li class="js-percentile-work_23281770 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23281770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23281770"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23281770 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23281770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23281770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23281770]").text(description); $(".js-view-count-work_23281770").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23281770").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23281770"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="41783" rel="nofollow" href="https://www.academia.edu/Documents/in/Ghrelin">Ghrelin</a>, <script data-card-contents-for-ri="41783" type="text/json">{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71511" rel="nofollow" href="https://www.academia.edu/Documents/in/Diabetes_mellitus">Diabetes mellitus</a>, <script data-card-contents-for-ri="71511" type="text/json">{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="90514" rel="nofollow" href="https://www.academia.edu/Documents/in/Cholesterol">Cholesterol</a><script data-card-contents-for-ri="90514" type="text/json">{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23281770]'), work: {"id":23281770,"title":"Emerging markers of cachexia predict survival in cancer patients","created_at":"2016-03-15T08:26:18.887-07:00","url":"https://www.academia.edu/23281770/Emerging_markers_of_cachexia_predict_survival_in_cancer_patients?f_ri=49633","dom_id":"work_23281770","summary":"Background: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. Methods: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. Results: Ghrelin levels were significantly higher in cancer patients than in healthy subjects (573.31 ± 130 vs 320.20 ± 66.48 ng/ml, p \u003c 0.0001), while obestatin (17.42 ± 7.12 vs 24.89 ± 5.54 ng/ml, p \u003c 0.0001) and leptin (38.4 ± 21.2 vs 76.28 ± 17.48 ng/ml, p \u003c 0.0001) values were lower. At ROC analyses the diagnostic profile of ghrelin (AUC 0.962; sensitivity 83%; specificity 98%), obestatin (AUC 0.798; sensitivity 74.5%; specificity 81.5%) and leptin (AUC 0.828; sensitivity 79%; specificity 73%) was superior to that of albumin (AUC 0.547; sensitivity 63%, specificity 69.4%) for detecting cachexia among cancer patients. On Cox multivariate analyses ghrelin (HR 1.02; 95% CI 1.01 -1.03; p \u003c 0.0001) and leptin (HR 0.94; 95% CI 0.92 -0.96; p \u003c 0.0001) were significant predictors of death even after correction for other known risk factors such as presence of metastasis and chronic kidney disease. Conclusion: Ghrelin and leptin are promising biomarkers to diagnose cachexia and to predict survival in cancer patients.","downloadable_attachments":[{"id":43751435,"asset_id":23281770,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45162731,"first_name":"Stefania","last_name":"Mondello","domain_name":"unime","page_name":"SMondello","display_name":"Stefania Mondello","profile_url":"https://unime.academia.edu/SMondello?f_ri=49633","photo":"https://0.academia-photos.com/45162731/28977264/27032638/s65_stefania.mondello.jpg"}],"research_interests":[{"id":41783,"name":"Ghrelin","url":"https://www.academia.edu/Documents/in/Ghrelin?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=49633","nofollow":true},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=49633","nofollow":true},{"id":135357,"name":"Leptin","url":"https://www.academia.edu/Documents/in/Leptin?f_ri=49633"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=49633"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=49633"},{"id":540859,"name":"Cachexia","url":"https://www.academia.edu/Documents/in/Cachexia?f_ri=49633"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=49633"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin?f_ri=49633"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=49633"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve?f_ri=49633"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=49633"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=49633"},{"id":2349258,"name":"Serum albumin","url":"https://www.academia.edu/Documents/in/Serum_albumin?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28391536" data-work_id="28391536" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28391536/Exercise_training_in_heart_failure_from_theory_to_practice_A_consensus_document_of_the_Heart_Failure_Association_and_the_European_Association_for_Cardiovascular_Prevention_and_Rehabilitation">Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28391536" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside specialized centres and in the real world of heart failure clinics. In reality, exercise intolerance can be successfully tackled by applying ET. We need to encourage the mindset that breathlessness may be evidence of signalling between the periphery and central haemodynamic performance and regular physical activity may ultimately bring about favourable changes in myocardial function, symptoms, functional capacity, and increased hospitalization-free life span and probably survival. In this position paper, we provide practical advice for the application of exercise in heart failure and how to overcome traditional barriers, based on the current scientific and clinical knowledge supporting the beneficial effect of this intervention.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28391536" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="34da325f2a4c3d949b7d7f8cc8fa76a1" rel="nofollow" data-download="{"attachment_id":48728902,"asset_id":28391536,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48728902/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="53225820" href="https://independent.academia.edu/BurkertPieske">Burkert Pieske</a><script data-card-contents-for-user="53225820" type="text/json">{"id":53225820,"first_name":"Burkert","last_name":"Pieske","domain_name":"independent","page_name":"BurkertPieske","display_name":"Burkert Pieske","profile_url":"https://independent.academia.edu/BurkertPieske?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_28391536 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="28391536"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 28391536, container: ".js-paper-rank-work_28391536", }); });</script></li><li class="js-percentile-work_28391536 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28391536; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_28391536"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_28391536 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="28391536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28391536; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28391536]").text(description); $(".js-view-count-work_28391536").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_28391536").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="28391536"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1237" rel="nofollow" href="https://www.academia.edu/Documents/in/Social_Sciences">Social Sciences</a>, <script data-card-contents-for-ri="1237" type="text/json">{"id":1237,"name":"Social Sciences","url":"https://www.academia.edu/Documents/in/Social_Sciences?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25443" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise_therapy">Exercise therapy</a>, <script data-card-contents-for-ri="25443" type="text/json">{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28391536]'), work: {"id":28391536,"title":"Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation","created_at":"2016-09-10T08:14:34.048-07:00","url":"https://www.academia.edu/28391536/Exercise_training_in_heart_failure_from_theory_to_practice_A_consensus_document_of_the_Heart_Failure_Association_and_the_European_Association_for_Cardiovascular_Prevention_and_Rehabilitation?f_ri=49633","dom_id":"work_28391536","summary":"The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside specialized centres and in the real world of heart failure clinics. In reality, exercise intolerance can be successfully tackled by applying ET. We need to encourage the mindset that breathlessness may be evidence of signalling between the periphery and central haemodynamic performance and regular physical activity may ultimately bring about favourable changes in myocardial function, symptoms, functional capacity, and increased hospitalization-free life span and probably survival. In this position paper, we provide practical advice for the application of exercise in heart failure and how to overcome traditional barriers, based on the current scientific and clinical knowledge supporting the beneficial effect of this intervention.","downloadable_attachments":[{"id":48728902,"asset_id":28391536,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":53225820,"first_name":"Burkert","last_name":"Pieske","domain_name":"independent","page_name":"BurkertPieske","display_name":"Burkert Pieske","profile_url":"https://independent.academia.edu/BurkertPieske?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1237,"name":"Social Sciences","url":"https://www.academia.edu/Documents/in/Social_Sciences?f_ri=49633","nofollow":true},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=49633","nofollow":true},{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":75826,"name":"Europe","url":"https://www.academia.edu/Documents/in/Europe?f_ri=49633"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=49633"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=49633"},{"id":746572,"name":"Implantable defibrillators-cardioverters","url":"https://www.academia.edu/Documents/in/Implantable_defibrillators-cardioverters?f_ri=49633"},{"id":2491318,"name":"Guideline Adherence","url":"https://www.academia.edu/Documents/in/Guideline_Adherence?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73937468" data-work_id="73937468" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73937468/%CE%B2_Blockers">β-Blockers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">British Library Cataloguing in Publication Data Handbook of pediatric cardiovascular drugs 1. 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Cardiovascular system-Diseases-Chemotherapy","downloadable_attachments":[{"id":83822413,"asset_id":73937468,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":59200228,"first_name":"Traci","last_name":"Kazmerski","domain_name":"independent","page_name":"TraciKazmerski","display_name":"Traci Kazmerski","profile_url":"https://independent.academia.edu/TraciKazmerski?f_ri=49633","photo":"https://gravatar.com/avatar/e8f25096074489777b1aeb6753b570fd?s=65"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true},{"id":749957,"name":"Right Ventricle","url":"https://www.academia.edu/Documents/in/Right_Ventricle?f_ri=49633","nofollow":true},{"id":2938568,"name":"single ventricle","url":"https://www.academia.edu/Documents/in/single_ventricle?f_ri=49633","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16304097" data-work_id="16304097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16304097/Thyroid_Disease_and_the_Heart">Thyroid Disease and the Heart</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Abstract—The cardiovascular signs and symptoms,of thyroid disease are some of the most profound and clinically relevant findings that accompany,both hyperthyroidism,and hypothyroidism. On the basis of the understanding of the cellular... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16304097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Abstract—The cardiovascular signs and symptoms,of thyroid disease are some of the most profound and clinically relevant findings that accompany,both hyperthyroidism,and hypothyroidism. On the basis of the understanding of the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16304097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3016b51b79b254b6b3eecf19ee056631" rel="nofollow" data-download="{"attachment_id":38935132,"asset_id":16304097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38935132/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35408333" href="https://independent.academia.edu/IrwinKlein">Irwin Klein</a><script data-card-contents-for-user="35408333" type="text/json">{"id":35408333,"first_name":"Irwin","last_name":"Klein","domain_name":"independent","page_name":"IrwinKlein","display_name":"Irwin Klein","profile_url":"https://independent.academia.edu/IrwinKlein?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16304097 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16304097"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16304097, container: ".js-paper-rank-work_16304097", }); 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$(".js-view-count[data-work-id=16304097]").text(description); $(".js-view-count-work_16304097").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16304097").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16304097"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">23</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1085" rel="nofollow" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88114" rel="nofollow" href="https://www.academia.edu/Documents/in/Congestive_Heart_Failure">Congestive Heart Failure</a>, <script data-card-contents-for-ri="88114" type="text/json">{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88321" rel="nofollow" href="https://www.academia.edu/Documents/in/Blood_Pressure">Blood Pressure</a><script data-card-contents-for-ri="88321" type="text/json">{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16304097]'), work: {"id":16304097,"title":"Thyroid Disease and the Heart","created_at":"2015-09-29T15:35:26.423-07:00","url":"https://www.academia.edu/16304097/Thyroid_Disease_and_the_Heart?f_ri=49633","dom_id":"work_16304097","summary":"Abstract—The cardiovascular signs and symptoms,of thyroid disease are some of the most profound and clinically relevant findings that accompany,both hyperthyroidism,and hypothyroidism. On the basis of the understanding of the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system, it is possible to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm disturbances","downloadable_attachments":[{"id":38935132,"asset_id":16304097,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35408333,"first_name":"Irwin","last_name":"Klein","domain_name":"independent","page_name":"IrwinKlein","display_name":"Irwin Klein","profile_url":"https://independent.academia.edu/IrwinKlein?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":88114,"name":"Congestive Heart 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class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25772905" data-work_id="25772905" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25772905/Percutaneous_closure_of_acquired_Gerbode_defect_management_of_a_rare_complication_of_cardiac_surgery">Percutaneous closure of acquired Gerbode defect: management of a rare complication of cardiac surgery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although rare, acquired Gerbode defect (abnormal communication between left ventricle and right atrium) may result as a complication of myocardial infarction, endocarditis as well as aortic or mitral valve replacement resulting in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25772905" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although rare, acquired Gerbode defect (abnormal communication between left ventricle and right atrium) may result as a complication of myocardial infarction, endocarditis as well as aortic or mitral valve replacement resulting in resistant heart failure secondary to significant left to right shunting. We are reporting the case of a 50-year old lady with repeated aortic valve replacement presenting with resistant heart failure secondary to an acquired Gerbode defect. Management of this defect in these high-risk patients may be challenging and percutaneous closure, if feasible, may represent the best management option.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25772905" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="308993a3882c009c10258e6b4d1ace70" rel="nofollow" data-download="{"attachment_id":46129596,"asset_id":25772905,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46129596/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49517054" href="https://christianacare.academia.edu/NiksadAbraham">Niksad Abraham</a><script data-card-contents-for-user="49517054" type="text/json">{"id":49517054,"first_name":"Niksad","last_name":"Abraham","domain_name":"christianacare","page_name":"NiksadAbraham","display_name":"Niksad Abraham","profile_url":"https://christianacare.academia.edu/NiksadAbraham?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25772905 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25772905"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25772905, container: ".js-paper-rank-work_25772905", }); 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$(".js-view-count[data-work-id=25772905]").text(description); $(".js-view-count-work_25772905").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25772905").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25772905"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="291048" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiac_Catheterization">Cardiac Catheterization</a>, <script data-card-contents-for-ri="291048" type="text/json">{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="410370" rel="nofollow" href="https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1">Public health systems and services research</a><script data-card-contents-for-ri="410370" type="text/json">{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25772905]'), work: {"id":25772905,"title":"Percutaneous closure of acquired Gerbode defect: management of a rare complication of cardiac surgery","created_at":"2016-06-01T05:08:42.571-07:00","url":"https://www.academia.edu/25772905/Percutaneous_closure_of_acquired_Gerbode_defect_management_of_a_rare_complication_of_cardiac_surgery?f_ri=49633","dom_id":"work_25772905","summary":"Although rare, acquired Gerbode defect (abnormal communication between left ventricle and right atrium) may result as a complication of myocardial infarction, endocarditis as well as aortic or mitral valve replacement resulting in resistant heart failure secondary to significant left to right shunting. We are reporting the case of a 50-year old lady with repeated aortic valve replacement presenting with resistant heart failure secondary to an acquired Gerbode defect. Management of this defect in these high-risk patients may be challenging and percutaneous closure, if feasible, may represent the best management option.","downloadable_attachments":[{"id":46129596,"asset_id":25772905,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49517054,"first_name":"Niksad","last_name":"Abraham","domain_name":"christianacare","page_name":"NiksadAbraham","display_name":"Niksad Abraham","profile_url":"https://christianacare.academia.edu/NiksadAbraham?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=49633","nofollow":true},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633","nofollow":true},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=49633"},{"id":1264978,"name":"Aortic Valve","url":"https://www.academia.edu/Documents/in/Aortic_Valve?f_ri=49633"},{"id":2463621,"name":"Postoperative Complications","url":"https://www.academia.edu/Documents/in/Postoperative_Complications?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13486325" data-work_id="13486325" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/13486325/Cardiac_Rehabilitation_Exercise_Training_and_Psychosocial_Risk_Factors">Cardiac Rehabilitation, Exercise Training, and Psychosocial Risk Factors</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We review data from our institution demonstrating the benefits of cardiac rehabilitation and exercise training on coronary risk factors, exercise capacity, behavioral characteristics, and quality of life in various subgroups of patients.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13486325" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We review data from our institution demonstrating the benefits of cardiac rehabilitation and exercise training on coronary risk factors, exercise capacity, behavioral characteristics, and quality of life in various subgroups of patients. In addition, we discuss our research in several other areas of preventive cardiology, including lipid disorders, hypertension, left ventricular hypertrophy, fish oils, and antioxidants. We believe that we are now in a very exciting era in which a multifactorial approach to the primary and secondary prevention of coronary artery disease is needed in order to further reduce morbidity and mortality rates.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13486325" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c8b07d8deaeb0c2ab89ce7372717816b" rel="nofollow" data-download="{"attachment_id":45284762,"asset_id":13486325,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45284762/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32697394" rel="nofollow" href="https://independent.academia.edu/JamesBlumenthal">James Blumenthal</a><script data-card-contents-for-user="32697394" type="text/json">{"id":32697394,"first_name":"James","last_name":"Blumenthal","domain_name":"independent","page_name":"JamesBlumenthal","display_name":"James Blumenthal","profile_url":"https://independent.academia.edu/JamesBlumenthal?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13486325 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13486325"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13486325, container: ".js-paper-rank-work_13486325", }); });</script></li><li class="js-percentile-work_13486325 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13486325; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13486325"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13486325 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13486325"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13486325; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13486325]").text(description); $(".js-view-count-work_13486325").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13486325").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13486325"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">22</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3217" rel="nofollow" href="https://www.academia.edu/Documents/in/Depression">Depression</a>, <script data-card-contents-for-ri="3217" type="text/json">{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7471" rel="nofollow" href="https://www.academia.edu/Documents/in/Life_Style">Life Style</a>, <script data-card-contents-for-ri="7471" type="text/json">{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8207" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk">Risk</a>, <script data-card-contents-for-ri="8207" type="text/json">{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25443" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise_therapy">Exercise therapy</a><script data-card-contents-for-ri="25443" type="text/json">{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13486325]'), work: {"id":13486325,"title":"Cardiac Rehabilitation, Exercise Training, and Psychosocial Risk Factors","created_at":"2015-07-01T04:38:35.603-07:00","url":"https://www.academia.edu/13486325/Cardiac_Rehabilitation_Exercise_Training_and_Psychosocial_Risk_Factors?f_ri=49633","dom_id":"work_13486325","summary":"We review data from our institution demonstrating the benefits of cardiac rehabilitation and exercise training on coronary risk factors, exercise capacity, behavioral characteristics, and quality of life in various subgroups of patients. In addition, we discuss our research in several other areas of preventive cardiology, including lipid disorders, hypertension, left ventricular hypertrophy, fish oils, and antioxidants. We believe that we are now in a very exciting era in which a multifactorial approach to the primary and secondary prevention of coronary artery disease is needed in order to further reduce morbidity and mortality rates.","downloadable_attachments":[{"id":45284762,"asset_id":13486325,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32697394,"first_name":"James","last_name":"Blumenthal","domain_name":"independent","page_name":"JamesBlumenthal","display_name":"James Blumenthal","profile_url":"https://independent.academia.edu/JamesBlumenthal?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=49633","nofollow":true},{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style?f_ri=49633","nofollow":true},{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk?f_ri=49633","nofollow":true},{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=49633"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants?f_ri=49633"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=49633"},{"id":95056,"name":"Omega-3 fatty acids","url":"https://www.academia.edu/Documents/in/Omega-3_fatty_acids?f_ri=49633"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=49633"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction?f_ri=49633"},{"id":395473,"name":"Patient Care Team","url":"https://www.academia.edu/Documents/in/Patient_Care_Team?f_ri=49633"},{"id":398808,"name":"Coronary heart disease","url":"https://www.academia.edu/Documents/in/Coronary_heart_disease?f_ri=49633"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=49633"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=49633"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=49633"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=49633"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1?f_ri=49633"},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13891443" data-work_id="13891443" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13891443/Idiopathic_restrictive_cardiomyopathy_in_the_young_report_of_two_cases">Idiopathic restrictive cardiomyopathy in the young: report of two cases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Rapezzi C, Ortolani P, Binetti G, Picchio FM, Magnani B. Idiopathic restrictive cardiomyopathy in the young: report of two cases. Int J Cardiol 1990;29:121-126.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13891443" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="07f1b4d2417161c41eb786c16eeace15" rel="nofollow" data-download="{"attachment_id":44831462,"asset_id":13891443,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44831462/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32964184" href="https://independent.academia.edu/FernandoPicchio">Fernando Picchio</a><script data-card-contents-for-user="32964184" type="text/json">{"id":32964184,"first_name":"Fernando","last_name":"Picchio","domain_name":"independent","page_name":"FernandoPicchio","display_name":"Fernando Picchio","profile_url":"https://independent.academia.edu/FernandoPicchio?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13891443 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13891443"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13891443, container: ".js-paper-rank-work_13891443", }); });</script></li><li class="js-percentile-work_13891443 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13891443; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13891443"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13891443 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13891443"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13891443; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13891443]").text(description); $(".js-view-count-work_13891443").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13891443").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13891443"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="39000" rel="nofollow" href="https://www.academia.edu/Documents/in/Electrocardiography">Electrocardiography</a>, <script data-card-contents-for-ri="39000" type="text/json">{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a>, <script data-card-contents-for-ri="46824" type="text/json">{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13891443]'), work: {"id":13891443,"title":"Idiopathic restrictive cardiomyopathy in the young: report of two cases","created_at":"2015-07-10T08:52:58.469-07:00","url":"https://www.academia.edu/13891443/Idiopathic_restrictive_cardiomyopathy_in_the_young_report_of_two_cases?f_ri=49633","dom_id":"work_13891443","summary":"Rapezzi C, Ortolani P, Binetti G, Picchio FM, Magnani B. Idiopathic restrictive cardiomyopathy in the young: report of two cases. Int J Cardiol 1990;29:121-126.","downloadable_attachments":[{"id":44831462,"asset_id":13891443,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32964184,"first_name":"Fernando","last_name":"Picchio","domain_name":"independent","page_name":"FernandoPicchio","display_name":"Fernando Picchio","profile_url":"https://independent.academia.edu/FernandoPicchio?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography?f_ri=49633","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=49633"},{"id":247701,"name":"Angiography","url":"https://www.academia.edu/Documents/in/Angiography?f_ri=49633"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=49633"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20107718 coauthored" data-work_id="20107718" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20107718/556_The_SWAT_Team_Approach_for_Treating_the_Unstable_Patient_in_Acute_Cardiopulmonary_Shock">556: The SWAT Team Approach for Treating the Unstable Patient in Acute Cardiopulmonary Shock</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: 123 I-MIBG uptake improves in patients recovered with LVAD and drug combination therapy. MIBG uptake is assessed using Heart/ Mediastinum (H/M) ratio and washout rate (W/O). After drawing a region of interest (ROI) around the LV,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20107718" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: 123 I-MIBG uptake improves in patients recovered with LVAD and drug combination therapy. MIBG uptake is assessed using Heart/ Mediastinum (H/M) ratio and washout rate (W/O). After drawing a region of interest (ROI) around the LV, the average myocardial counts per pixel is calculated. A large heart will have an apparent lower MIBG uptake due to lower average counts per pixel than a smaller heart despite unchanged sympathetic function. In this study we investigated whether changes in MIBG uptake in LVAD patients is secondary to reduction in LV size or improvement in the uptake mechanism itself. Methods and Materials: MIBG uptake was assessed serially in 9 LVAD patients at two time points, T1 and T2 (40 Ϯ 20 days and 289 Ϯ 84 days following device implantation, respectively). Planar scintigraphy in the anterior projection was performed at 15 minutes and 4 hours. ROI were drawn over the heart excluding the LVAD. Counts per pixel were calculated for each ROI to obtain early and delayed H/M ratios and W/O rate. To index for LV size, ROIs drawn at T1 were superimposed on acquisitions acquired at T2 and the H/M ratios and the W/O rate were re-calculated.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20107718" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="aa81847f201f202a49ebd4797b5b36e1" rel="nofollow" data-download="{"attachment_id":41990467,"asset_id":20107718,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41990467/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36706580" href="https://independent.academia.edu/DawnJaroszewski">Dawn Jaroszewski</a><script data-card-contents-for-user="36706580" type="text/json">{"id":36706580,"first_name":"Dawn","last_name":"Jaroszewski","domain_name":"independent","page_name":"DawnJaroszewski","display_name":"Dawn Jaroszewski","profile_url":"https://independent.academia.edu/DawnJaroszewski?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-20107718">+1</span><div class="hidden js-additional-users-20107718"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/LouisLanza">Louis Lanza</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-20107718'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-20107718').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_20107718 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20107718"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20107718, container: ".js-paper-rank-work_20107718", }); });</script></li><li class="js-percentile-work_20107718 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20107718; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20107718"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20107718 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20107718"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20107718; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20107718]").text(description); $(".js-view-count-work_20107718").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20107718").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20107718"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1036494" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation">Heart and Lung Transplantation</a><script data-card-contents-for-ri="1036494" type="text/json">{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20107718]'), work: {"id":20107718,"title":"556: The SWAT Team Approach for Treating the Unstable Patient in Acute Cardiopulmonary Shock","created_at":"2016-01-08T11:09:58.032-08:00","url":"https://www.academia.edu/20107718/556_The_SWAT_Team_Approach_for_Treating_the_Unstable_Patient_in_Acute_Cardiopulmonary_Shock?f_ri=49633","dom_id":"work_20107718","summary":"Purpose: 123 I-MIBG uptake improves in patients recovered with LVAD and drug combination therapy. MIBG uptake is assessed using Heart/ Mediastinum (H/M) ratio and washout rate (W/O). After drawing a region of interest (ROI) around the LV, the average myocardial counts per pixel is calculated. A large heart will have an apparent lower MIBG uptake due to lower average counts per pixel than a smaller heart despite unchanged sympathetic function. In this study we investigated whether changes in MIBG uptake in LVAD patients is secondary to reduction in LV size or improvement in the uptake mechanism itself. Methods and Materials: MIBG uptake was assessed serially in 9 LVAD patients at two time points, T1 and T2 (40 Ϯ 20 days and 289 Ϯ 84 days following device implantation, respectively). Planar scintigraphy in the anterior projection was performed at 15 minutes and 4 hours. ROI were drawn over the heart excluding the LVAD. Counts per pixel were calculated for each ROI to obtain early and delayed H/M ratios and W/O rate. To index for LV size, ROIs drawn at T1 were superimposed on acquisitions acquired at T2 and the H/M ratios and the W/O rate were re-calculated.","downloadable_attachments":[{"id":41990467,"asset_id":20107718,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36706580,"first_name":"Dawn","last_name":"Jaroszewski","domain_name":"independent","page_name":"DawnJaroszewski","display_name":"Dawn Jaroszewski","profile_url":"https://independent.academia.edu/DawnJaroszewski?f_ri=49633","photo":"/images/s65_no_pic.png"},{"id":41145738,"first_name":"Louis","last_name":"Lanza","domain_name":"independent","page_name":"LouisLanza","display_name":"Louis Lanza","profile_url":"https://independent.academia.edu/LouisLanza?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":1036494,"name":"Heart and Lung Transplantation","url":"https://www.academia.edu/Documents/in/Heart_and_Lung_Transplantation?f_ri=49633","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19609539" data-work_id="19609539" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19609539/Atrial_septal_defect_in_adults_40_years_old_negative_impact_of_low_arterial_oxygen_saturation">Atrial septal defect in adults ≥40 years old: negative impact of low arterial oxygen saturation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19609539" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of presentation, anatomical characteristics, outcome and predictive factors for free-event survival of major cardiovascular and pulmonary events. Methods and results: Two-hundred survivors of atrial septal defect aged over 40-yr attended from 1985 to 1998 were reviewed and followed-up from 1.6 to 22 years. Patients were classified in three groups according to age at entry: Group 1, between 40 and 49; Group 2; 50 and 59; and Group 3, z 60 years old. The mean age at presentation was 48.8 F 9.2 years, and the most common clinical presentations were arrhythmia and dyspnea (51.4%). There were 37 (18.5%) events: 7 heart failure-related, 5 sudden death, 13 severe pulmonary infections, 5 embolisms, and 4 strokes. According to Cox's regression analysis, predictors of primary end point included age group at presentation (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54), and either pulmonary hypertension (mean pulmonary pressure > 35 mmHg; hazard ratio = 0.65 (4.6, confidence limits 2.2 to 9.5) or, arterial oxygen saturation < 80% (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54). Conclusions: This study supports that long term outcome of patients aged >40 years with unoperated ASD is importantly determined by the mPAP (>35 mmHg), SaO2% (_80) and the age at diagnosis. Nevertheless we identified an inverse association between the mPAP level and SaO2% (interaction). The event-free survival expectancy may be estimated using the age at diagnosis and either SaO2% or mPAP. This prognostic stratification based on pathophysiological principles, may help in making decisions for therapeutic interventions. SaO2% should always be measured as a part of the initial clinical approach of those patients with atrial septal defect aged over 40 years. D</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19609539" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="15b84071c432df40f835463a5791f496" rel="nofollow" data-download="{"attachment_id":42072642,"asset_id":19609539,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42072642/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40029084" href="https://unac.academia.edu/CarlosCastellanos">Carlos Castellanos</a><script data-card-contents-for-user="40029084" type="text/json">{"id":40029084,"first_name":"Carlos","last_name":"Castellanos","domain_name":"unac","page_name":"CarlosCastellanos","display_name":"Carlos Castellanos","profile_url":"https://unac.academia.edu/CarlosCastellanos?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_19609539 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19609539"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19609539, container: ".js-paper-rank-work_19609539", }); });</script></li><li class="js-percentile-work_19609539 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19609539; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_19609539"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_19609539 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="19609539"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19609539; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19609539]").text(description); $(".js-view-count-work_19609539").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19609539").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19609539"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">27</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25436" rel="nofollow" href="https://www.academia.edu/Documents/in/Stratification">Stratification</a>, <script data-card-contents-for-ri="25436" type="text/json">{"id":25436,"name":"Stratification","url":"https://www.academia.edu/Documents/in/Stratification?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a><script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19609539]'), work: {"id":19609539,"title":"Atrial septal defect in adults ≥40 years old: negative impact of low arterial oxygen saturation","created_at":"2015-12-11T08:47:06.586-08:00","url":"https://www.academia.edu/19609539/Atrial_septal_defect_in_adults_40_years_old_negative_impact_of_low_arterial_oxygen_saturation?f_ri=49633","dom_id":"work_19609539","summary":"Background: Although good prognosis and clinical long-term outcome have been commonly reported in minimally symptomatic adult patients with ASD, this information has been based on studies with a relatively small number of adult patients. We studied unoperated patients aged over 40 years to define the patterns of presentation, anatomical characteristics, outcome and predictive factors for free-event survival of major cardiovascular and pulmonary events. Methods and results: Two-hundred survivors of atrial septal defect aged over 40-yr attended from 1985 to 1998 were reviewed and followed-up from 1.6 to 22 years. Patients were classified in three groups according to age at entry: Group 1, between 40 and 49; Group 2; 50 and 59; and Group 3, z 60 years old. The mean age at presentation was 48.8 F 9.2 years, and the most common clinical presentations were arrhythmia and dyspnea (51.4%). There were 37 (18.5%) events: 7 heart failure-related, 5 sudden death, 13 severe pulmonary infections, 5 embolisms, and 4 strokes. According to Cox's regression analysis, predictors of primary end point included age group at presentation (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54), and either pulmonary hypertension (mean pulmonary pressure \u003e 35 mmHg; hazard ratio = 0.65 (4.6, confidence limits 2.2 to 9.5) or, arterial oxygen saturation \u003c 80% (hazard ratio 1.71, 95% confidence limits 1.16 to 2.54). Conclusions: This study supports that long term outcome of patients aged \u003e40 years with unoperated ASD is importantly determined by the mPAP (\u003e35 mmHg), SaO2% (_80) and the age at diagnosis. Nevertheless we identified an inverse association between the mPAP level and SaO2% (interaction). The event-free survival expectancy may be estimated using the age at diagnosis and either SaO2% or mPAP. This prognostic stratification based on pathophysiological principles, may help in making decisions for therapeutic interventions. SaO2% should always be measured as a part of the initial clinical approach of those patients with atrial septal defect aged over 40 years. D","downloadable_attachments":[{"id":42072642,"asset_id":19609539,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40029084,"first_name":"Carlos","last_name":"Castellanos","domain_name":"unac","page_name":"CarlosCastellanos","display_name":"Carlos Castellanos","profile_url":"https://unac.academia.edu/CarlosCastellanos?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=49633","nofollow":true},{"id":25436,"name":"Stratification","url":"https://www.academia.edu/Documents/in/Stratification?f_ri=49633","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":59748,"name":"Sudden Death","url":"https://www.academia.edu/Documents/in/Sudden_Death?f_ri=49633"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=49633"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=49633"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":164831,"name":"Dyspnea","url":"https://www.academia.edu/Documents/in/Dyspnea?f_ri=49633"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=49633"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=49633"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=49633"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=49633"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=49633"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=49633"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=49633"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=49633"},{"id":735030,"name":"Congenital Heart Disease","url":"https://www.academia.edu/Documents/in/Congenital_Heart_Disease?f_ri=49633"},{"id":746681,"name":"Arrhythmia","url":"https://www.academia.edu/Documents/in/Arrhythmia?f_ri=49633"},{"id":985062,"name":"Clinical Presentation","url":"https://www.academia.edu/Documents/in/Clinical_Presentation?f_ri=49633"},{"id":1228884,"name":"Confidence Limit","url":"https://www.academia.edu/Documents/in/Confidence_Limit?f_ri=49633"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=49633"},{"id":1325909,"name":"Atrial Septal Defect","url":"https://www.academia.edu/Documents/in/Atrial_Septal_Defect?f_ri=49633"},{"id":1470936,"name":"Age Groups","url":"https://www.academia.edu/Documents/in/Age_Groups?f_ri=49633"},{"id":1558342,"name":"Oxygen saturation","url":"https://www.academia.edu/Documents/in/Oxygen_saturation?f_ri=49633"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48727123" data-work_id="48727123" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/48727123/Heart_Failure_in_Young_Adults_Is_Associated_With_High_Mortality_A_Contemporary_Population_Level_Analysis">Heart Failure in Young Adults Is Associated With High Mortality: A Contemporary Population-Level Analysis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background. Data on young patients with heart failure (HF) are sparse. We examined the characteristics, healthcare utilization and survival of younger versus older patients with HF. Methods. Analysis of linked administrative databases in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48727123" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background. Data on young patients with heart failure (HF) are sparse. We examined the characteristics, healthcare utilization and survival of younger versus older patients with HF. Methods. Analysis of linked administrative databases in Alberta, Canada. 34,548 patients with first hospitalization for HF as principal diagnosis were identified from 2002 to 2014. Patients were stratified into four age groups: 20-44, 45-54, 55-64, and ≥65 years. Results. Of the 34548 patients, 496 (1.4%), 1319 (3.8%), 3359 (9.7%) and 29374 (85%) patients were aged 20-44, 45-54, 55-64 and ≥65 years, respectively. Incidence of HF hospitalization decreased over time among patients ≥65 years, and increased among men aged 20-64 years. In the year following the index HF hospitalization, younger compared to older patients were less likely to present to the emergency department (ED) (e.g. 67.2% of those aged 20-44 years vs. 74.8% of those aged ≥65 years) or be hospitalized: for any reason (48.5% vs. 61.2%), cardiovascular causes (28.6% vs. 34.4%), or HF (14.8% vs. 23.6%). Mortality rates were lower in younger patients aged 20-44 years, but still substantial: 3.9%, 12.4%, and 27.7% at 30 days, 1 year, and 5 years respectively. Conclusions. Although young patients, especially those <45 years of age, accounted for a small proportion of the total population, adverse events were frequent, with half of the younger patients being readmitted, two thirds presenting to an ED, and over 10% dying within a year.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48727123" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="70b58fefbf18a9b38b7f928b7ca65280" rel="nofollow" data-download="{"attachment_id":67191279,"asset_id":48727123,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67191279/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64545696" rel="nofollow" href="https://independent.academia.edu/AnamariaSavu1">Anamaria Savu</a><script data-card-contents-for-user="64545696" type="text/json">{"id":64545696,"first_name":"Anamaria","last_name":"Savu","domain_name":"independent","page_name":"AnamariaSavu1","display_name":"Anamaria Savu","profile_url":"https://independent.academia.edu/AnamariaSavu1?f_ri=49633","photo":"https://0.academia-photos.com/64545696/89568328/78284639/s65_anamaria.savu.png"}</script></span></span></li><li class="js-paper-rank-work_48727123 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48727123"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48727123, container: ".js-paper-rank-work_48727123", }); });</script></li><li class="js-percentile-work_48727123 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48727123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48727123"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48727123 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48727123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48727123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48727123]").text(description); $(".js-view-count-work_48727123").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48727123").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48727123"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="96213" rel="nofollow" href="https://www.academia.edu/Documents/in/Hospitalization">Hospitalization</a>, <script data-card-contents-for-ri="96213" type="text/json">{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="133057" rel="nofollow" href="https://www.academia.edu/Documents/in/Young_Adult">Young Adult</a>, <script data-card-contents-for-ri="133057" type="text/json">{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a><script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48727123]'), work: {"id":48727123,"title":"Heart Failure in Young Adults Is Associated With High Mortality: A Contemporary Population-Level Analysis","created_at":"2021-05-05T07:42:18.226-07:00","url":"https://www.academia.edu/48727123/Heart_Failure_in_Young_Adults_Is_Associated_With_High_Mortality_A_Contemporary_Population_Level_Analysis?f_ri=49633","dom_id":"work_48727123","summary":"Background. Data on young patients with heart failure (HF) are sparse. We examined the characteristics, healthcare utilization and survival of younger versus older patients with HF. Methods. Analysis of linked administrative databases in Alberta, Canada. 34,548 patients with first hospitalization for HF as principal diagnosis were identified from 2002 to 2014. Patients were stratified into four age groups: 20-44, 45-54, 55-64, and ≥65 years. Results. Of the 34548 patients, 496 (1.4%), 1319 (3.8%), 3359 (9.7%) and 29374 (85%) patients were aged 20-44, 45-54, 55-64 and ≥65 years, respectively. Incidence of HF hospitalization decreased over time among patients ≥65 years, and increased among men aged 20-64 years. In the year following the index HF hospitalization, younger compared to older patients were less likely to present to the emergency department (ED) (e.g. 67.2% of those aged 20-44 years vs. 74.8% of those aged ≥65 years) or be hospitalized: for any reason (48.5% vs. 61.2%), cardiovascular causes (28.6% vs. 34.4%), or HF (14.8% vs. 23.6%). Mortality rates were lower in younger patients aged 20-44 years, but still substantial: 3.9%, 12.4%, and 27.7% at 30 days, 1 year, and 5 years respectively. Conclusions. Although young patients, especially those \u003c45 years of age, accounted for a small proportion of the total population, adverse events were frequent, with half of the younger patients being readmitted, two thirds presenting to an ED, and over 10% dying within a year.","downloadable_attachments":[{"id":67191279,"asset_id":48727123,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64545696,"first_name":"Anamaria","last_name":"Savu","domain_name":"independent","page_name":"AnamariaSavu1","display_name":"Anamaria Savu","profile_url":"https://independent.academia.edu/AnamariaSavu1?f_ri=49633","photo":"https://0.academia-photos.com/64545696/89568328/78284639/s65_anamaria.savu.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=49633","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=49633","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":356669,"name":"Alberta","url":"https://www.academia.edu/Documents/in/Alberta?f_ri=49633"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11937077" data-work_id="11937077" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11937077/Effect_of_a_Seated_Exercise_Program_to_Improve_Physical_Function_and_Health_Status_in_Frail_Patients_70_Years_of_Age_With_Heart_Failure">Effect of a Seated Exercise Program to Improve Physical Function and Health Status in Frail Patients ≥70 Years of Age With Heart Failure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Eighty-two patients aged >70 years with heart failure were randomized to a gentle, seated exercise program or to usual care. Six-minute walk distance and quality of life did not change between groups, but daily activity as measured by... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11937077" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Eighty-two patients aged >70 years with heart failure were randomized to a gentle, seated exercise program or to usual care. Six-minute walk distance and quality of life did not change between groups, but daily activity as measured by accelerometry increased in the exercise group relative to the control group. ᮊ2005</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11937077" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="838b8d3bb84058357d157e7bf4dfbe68" rel="nofollow" data-download="{"attachment_id":46429759,"asset_id":11937077,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46429759/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="29580095" href="https://aberdeen.academia.edu/DerekJohnston">Derek Johnston</a><script data-card-contents-for-user="29580095" type="text/json">{"id":29580095,"first_name":"Derek","last_name":"Johnston","domain_name":"aberdeen","page_name":"DerekJohnston","display_name":"Derek Johnston","profile_url":"https://aberdeen.academia.edu/DerekJohnston?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11937077 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11937077"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11937077, container: ".js-paper-rank-work_11937077", }); });</script></li><li class="js-percentile-work_11937077 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11937077; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11937077"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11937077 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11937077"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11937077; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11937077]").text(description); $(".js-view-count-work_11937077").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11937077").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11937077"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="202" rel="nofollow" href="https://www.academia.edu/Documents/in/Program_Evaluation">Program Evaluation</a>, <script data-card-contents-for-ri="202" type="text/json">{"id":202,"name":"Program Evaluation","url":"https://www.academia.edu/Documents/in/Program_Evaluation?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25443" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise_therapy">Exercise therapy</a>, <script data-card-contents-for-ri="25443" type="text/json">{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="73118" rel="nofollow" href="https://www.academia.edu/Documents/in/Walking">Walking</a><script data-card-contents-for-ri="73118" type="text/json">{"id":73118,"name":"Walking","url":"https://www.academia.edu/Documents/in/Walking?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11937077]'), work: {"id":11937077,"title":"Effect of a Seated Exercise Program to Improve Physical Function and Health Status in Frail Patients ≥70 Years of Age With Heart Failure","created_at":"2015-04-14T01:57:31.995-07:00","url":"https://www.academia.edu/11937077/Effect_of_a_Seated_Exercise_Program_to_Improve_Physical_Function_and_Health_Status_in_Frail_Patients_70_Years_of_Age_With_Heart_Failure?f_ri=49633","dom_id":"work_11937077","summary":"Eighty-two patients aged \u003e70 years with heart failure were randomized to a gentle, seated exercise program or to usual care. Six-minute walk distance and quality of life did not change between groups, but daily activity as measured by accelerometry increased in the exercise group relative to the control group. ᮊ2005","downloadable_attachments":[{"id":46429759,"asset_id":11937077,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":29580095,"first_name":"Derek","last_name":"Johnston","domain_name":"aberdeen","page_name":"DerekJohnston","display_name":"Derek Johnston","profile_url":"https://aberdeen.academia.edu/DerekJohnston?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":202,"name":"Program Evaluation","url":"https://www.academia.edu/Documents/in/Program_Evaluation?f_ri=49633","nofollow":true},{"id":25443,"name":"Exercise therapy","url":"https://www.academia.edu/Documents/in/Exercise_therapy?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":73118,"name":"Walking","url":"https://www.academia.edu/Documents/in/Walking?f_ri=49633","nofollow":true},{"id":228356,"name":"Posture","url":"https://www.academia.edu/Documents/in/Posture?f_ri=49633"},{"id":232534,"name":"Health Status","url":"https://www.academia.edu/Documents/in/Health_Status?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":1115362,"name":"Physical Function","url":"https://www.academia.edu/Documents/in/Physical_Function?f_ri=49633"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=49633"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity?f_ri=49633"},{"id":2466765,"name":"Frail elderly","url":"https://www.academia.edu/Documents/in/Frail_elderly?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78124300" data-work_id="78124300" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78124300/How_to_fix_a_broken_heart_Cardiac_disease_and_the_multiverse_of_stem_cell_research_in_Canada">How to fix a broken heart: Cardiac disease and the ‘multiverse’ of stem cell research in Canada</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">You have to have a good cell to repair the heart. (Researcher B) Stem cell treatments, in many cases, are 'technologies of hope' for patients suffering from a severely disabling, sometimes mortal, health condition (see ; also Leibing and</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78124300" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bd508604d5577d921b9798ed404abc0d" rel="nofollow" data-download="{"attachment_id":85281759,"asset_id":78124300,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85281759/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36999864" href="https://independent.academia.edu/RachelMenezes">Rachel Menezes</a><script data-card-contents-for-user="36999864" type="text/json">{"id":36999864,"first_name":"Rachel","last_name":"Menezes","domain_name":"independent","page_name":"RachelMenezes","display_name":"Rachel Menezes","profile_url":"https://independent.academia.edu/RachelMenezes?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78124300 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78124300"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78124300, container: ".js-paper-rank-work_78124300", }); });</script></li><li class="js-percentile-work_78124300 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78124300; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78124300"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78124300 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78124300"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78124300; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78124300]").text(description); $(".js-view-count-work_78124300").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78124300").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78124300"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="184" rel="nofollow" href="https://www.academia.edu/Documents/in/Sociology">Sociology</a>, <script data-card-contents-for-ri="184" type="text/json">{"id":184,"name":"Sociology","url":"https://www.academia.edu/Documents/in/Sociology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="200" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Sociology">Medical Sociology</a>, <script data-card-contents-for-ri="200" type="text/json">{"id":200,"name":"Medical Sociology","url":"https://www.academia.edu/Documents/in/Medical_Sociology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="767" rel="nofollow" href="https://www.academia.edu/Documents/in/Anthropology">Anthropology</a>, <script data-card-contents-for-ri="767" type="text/json">{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="793" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Anthropology">Medical Anthropology</a><script data-card-contents-for-ri="793" type="text/json">{"id":793,"name":"Medical Anthropology","url":"https://www.academia.edu/Documents/in/Medical_Anthropology?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78124300]'), work: {"id":78124300,"title":"How to fix a broken heart: Cardiac disease and the ‘multiverse’ of stem cell research in Canada","created_at":"2022-05-01T07:21:02.582-07:00","url":"https://www.academia.edu/78124300/How_to_fix_a_broken_heart_Cardiac_disease_and_the_multiverse_of_stem_cell_research_in_Canada?f_ri=49633","dom_id":"work_78124300","summary":"You have to have a good cell to repair the heart. (Researcher B) Stem cell treatments, in many cases, are 'technologies of hope' for patients suffering from a severely disabling, sometimes mortal, health condition (see ; also Leibing and","downloadable_attachments":[{"id":85281759,"asset_id":78124300,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36999864,"first_name":"Rachel","last_name":"Menezes","domain_name":"independent","page_name":"RachelMenezes","display_name":"Rachel Menezes","profile_url":"https://independent.academia.edu/RachelMenezes?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":184,"name":"Sociology","url":"https://www.academia.edu/Documents/in/Sociology?f_ri=49633","nofollow":true},{"id":200,"name":"Medical Sociology","url":"https://www.academia.edu/Documents/in/Medical_Sociology?f_ri=49633","nofollow":true},{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology?f_ri=49633","nofollow":true},{"id":793,"name":"Medical Anthropology","url":"https://www.academia.edu/Documents/in/Medical_Anthropology?f_ri=49633","nofollow":true},{"id":906,"name":"Applied Ethics","url":"https://www.academia.edu/Documents/in/Applied_Ethics?f_ri=49633"},{"id":1237,"name":"Social Sciences","url":"https://www.academia.edu/Documents/in/Social_Sciences?f_ri=49633"},{"id":3642,"name":"Stem Cells","url":"https://www.academia.edu/Documents/in/Stem_Cells?f_ri=49633"},{"id":3699,"name":"Stem cell and Regenerative medicine","url":"https://www.academia.edu/Documents/in/Stem_cell_and_Regenerative_medicine?f_ri=49633"},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=49633"},{"id":13514,"name":"STS (Anthropology)","url":"https://www.academia.edu/Documents/in/STS_Anthropology_?f_ri=49633"},{"id":21500,"name":"Social Studies Of Science","url":"https://www.academia.edu/Documents/in/Social_Studies_Of_Science?f_ri=49633"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada?f_ri=49633"},{"id":54424,"name":"science and technology studies (STS)","url":"https://www.academia.edu/Documents/in/science_and_technology_studies_STS_?f_ri=49633"},{"id":61603,"name":"Uncertainty","url":"https://www.academia.edu/Documents/in/Uncertainty?f_ri=49633"},{"id":78521,"name":"Social Gerontology","url":"https://www.academia.edu/Documents/in/Social_Gerontology?f_ri=49633"},{"id":86098,"name":"Critical gerontology","url":"https://www.academia.edu/Documents/in/Critical_gerontology?f_ri=49633"},{"id":228832,"name":"Heart Disease","url":"https://www.academia.edu/Documents/in/Heart_Disease?f_ri=49633"},{"id":626706,"name":"Social Studies of Science","url":"https://www.academia.edu/Documents/in/Social_Studies_of_Science-1?f_ri=49633"},{"id":1744493,"name":"Science and Technology Studies","url":"https://www.academia.edu/Documents/in/Science_and_Technology_Studies?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_74674709" data-work_id="74674709" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/74674709/Home_based_advance_care_programme_is_effective_in_reducing_hospitalisations_of_advanced_heart_failure_patients_a_clinical_and_healthcare_cost_study">Home-based advance care programme is effective in reducing hospitalisations of advanced heart failure patients: a clinical and healthcare cost study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In end-stage heart failure (HF) that is not eligible for mechanical assist device or heart transplant, palliative care serves to maximise symptom control and quality of life. We sought to evaluate the impact of home-based advance care... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_74674709" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In end-stage heart failure (HF) that is not eligible for mechanical assist device or heart transplant, palliative care serves to maximise symptom control and quality of life. We sought to evaluate the impact of home-based advance care programme (ACP) on healthcare utilisation in end-stage HF patients. Prospectively collected registry data on all end-stage HF recruited into ACP between July 2008 and July 2010 were analysed. Chart reviews were conducted on HF database and hospital electronic records. Phone interview and home visit details by ACP team were extracted to complete data entry. HF and all-cause hospitalisations 1 year before, and any time after ACP inception were defined as events. For the latter analysis, follow-up duration adjustment to event episodes was performed to account for death less than a year. Forty-four patients (mean age 79 years, 39% men) were followed up for 15±8 months. Fifty-seven percent had diabetes, 80% ischaemic heart disease, and 60% chronic kidney di...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/74674709" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ce66bb967298bf318911b9deed6b1dfb" rel="nofollow" data-download="{"attachment_id":82741311,"asset_id":74674709,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82741311/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="115789726" href="https://independent.academia.edu/AngelineSeah1">Angeline Seah</a><script data-card-contents-for-user="115789726" type="text/json">{"id":115789726,"first_name":"Angeline","last_name":"Seah","domain_name":"independent","page_name":"AngelineSeah1","display_name":"Angeline Seah","profile_url":"https://independent.academia.edu/AngelineSeah1?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_74674709 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="74674709"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 74674709, container: ".js-paper-rank-work_74674709", }); 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$(".js-view-count[data-work-id=74674709]").text(description); $(".js-view-count-work_74674709").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_74674709").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="74674709"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4482" rel="nofollow" href="https://www.academia.edu/Documents/in/Palliative_Care">Palliative Care</a>, <script data-card-contents-for-ri="4482" type="text/json">{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71511" rel="nofollow" href="https://www.academia.edu/Documents/in/Diabetes_mellitus">Diabetes mellitus</a><script data-card-contents-for-ri="71511" type="text/json">{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=74674709]'), work: {"id":74674709,"title":"Home-based advance care programme is effective in reducing hospitalisations of advanced heart failure patients: a clinical and healthcare cost study","created_at":"2022-03-27T01:57:55.373-07:00","url":"https://www.academia.edu/74674709/Home_based_advance_care_programme_is_effective_in_reducing_hospitalisations_of_advanced_heart_failure_patients_a_clinical_and_healthcare_cost_study?f_ri=49633","dom_id":"work_74674709","summary":"In end-stage heart failure (HF) that is not eligible for mechanical assist device or heart transplant, palliative care serves to maximise symptom control and quality of life. We sought to evaluate the impact of home-based advance care programme (ACP) on healthcare utilisation in end-stage HF patients. Prospectively collected registry data on all end-stage HF recruited into ACP between July 2008 and July 2010 were analysed. Chart reviews were conducted on HF database and hospital electronic records. Phone interview and home visit details by ACP team were extracted to complete data entry. HF and all-cause hospitalisations 1 year before, and any time after ACP inception were defined as events. For the latter analysis, follow-up duration adjustment to event episodes was performed to account for death less than a year. Forty-four patients (mean age 79 years, 39% men) were followed up for 15±8 months. Fifty-seven percent had diabetes, 80% ischaemic heart disease, and 60% chronic kidney di...","downloadable_attachments":[{"id":82741311,"asset_id":74674709,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":115789726,"first_name":"Angeline","last_name":"Seah","domain_name":"independent","page_name":"AngelineSeah1","display_name":"Angeline Seah","profile_url":"https://independent.academia.edu/AngelineSeah1?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=49633","nofollow":true},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=49633","nofollow":true},{"id":83471,"name":"Health Services","url":"https://www.academia.edu/Documents/in/Health_Services?f_ri=49633"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633"},{"id":209856,"name":"Registries","url":"https://www.academia.edu/Documents/in/Registries?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology?f_ri=49633"},{"id":906536,"name":"Health Care Costs","url":"https://www.academia.edu/Documents/in/Health_Care_Costs?f_ri=49633"},{"id":2503388,"name":"Myocardial Ischemia","url":"https://www.academia.edu/Documents/in/Myocardial_Ischemia?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34083012" data-work_id="34083012" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34083012/Age_related_Ventricular_Remodeling_is_an_Independent_Risk_for_Heart_Failure_Symptoms_in_Subjects_With_Preserved_Systolic_Function">Age-related Ventricular Remodeling is an Independent Risk for Heart Failure Symptoms in Subjects With Preserved Systolic Function</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">s u m m a r y Background: Age has been shown to be related with increased vascular stiffness, cardiac structural alterations, and geometric remodeling. Data regarding the relationship between clinical heart failure (HF) symptoms and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34083012" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">s u m m a r y Background: Age has been shown to be related with increased vascular stiffness, cardiac structural alterations, and geometric remodeling. Data regarding the relationship between clinical heart failure (HF) symptoms and aging-related alterations of ventricular geometries are scarce. We therefore investigated this issue. Methods: We subsequently studied 1,577 participants without cardiovascular or chronic lung disorders. Echocardiography-defined cardiac structures and left ventricular (LV) geometries, including LV mass, relative wall thickness, and mass-to-volume ratio were all determined. Baseline clinical variables, medical histories, and functional impairment in terms of HF symptoms during exercise were all obtained. Multivariate bootstrapping derived odds ratio from various models were used to represent the independent predictors for HF. Results: Of all, 1,459 participants (age: 49.3 AE 10.8; 36% female) with normal ejection fraction (66.8 AE 4.7%) were enrolled in our study. Cardiac structural alterations, ventricular geometric remodeling, and diastolic dysfunction were significantly related to aging process, along with increasing cardiovascular morbidities and risk factors. After adjusting for confounders and LV mass, change in ventricular geometries in terms of mass-to-volume ratio remained an independent risk, whereas relative wall thickness had a borderline significance for HF symptoms (odds ratio: 2.79 and 1.04, p ¼ 0.047 and 0.08, respectively). Conclusion: Cardiac structure, function, and various ventricular remodeling patterns were age-related. Such remodeling process is not only associated with a higher incidence of cardiovascular morbidities but also more likely to develop HF symptoms, which are independent of clinical variables and LV mass.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34083012" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6e515082d66f26ece3d92a35fa2311a5" rel="nofollow" data-download="{"attachment_id":54016702,"asset_id":34083012,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54016702/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="488231" href="https://independent.academia.edu/ChungLiehHung">Chung-Lieh Hung</a><script data-card-contents-for-user="488231" type="text/json">{"id":488231,"first_name":"Chung-Lieh","last_name":"Hung","domain_name":"independent","page_name":"ChungLiehHung","display_name":"Chung-Lieh Hung","profile_url":"https://independent.academia.edu/ChungLiehHung?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34083012 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34083012"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34083012, container: ".js-paper-rank-work_34083012", }); });</script></li><li class="js-percentile-work_34083012 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34083012; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_34083012"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_34083012 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="34083012"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34083012; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34083012]").text(description); $(".js-view-count-work_34083012").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34083012").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34083012"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="2506" rel="nofollow" href="https://www.academia.edu/Documents/in/Gerontology">Gerontology</a>, <script data-card-contents-for-ri="2506" type="text/json">{"id":2506,"name":"Gerontology","url":"https://www.academia.edu/Documents/in/Gerontology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88113" rel="nofollow" href="https://www.academia.edu/Documents/in/Left_Ventricular_Assist_Device">Left Ventricular Assist Device</a>, <script data-card-contents-for-ri="88113" type="text/json">{"id":88113,"name":"Left Ventricular Assist Device","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Assist_Device?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34083012]'), work: {"id":34083012,"title":"Age-related Ventricular Remodeling is an Independent Risk for Heart Failure Symptoms in Subjects With Preserved Systolic Function","created_at":"2017-07-30T21:59:25.442-07:00","url":"https://www.academia.edu/34083012/Age_related_Ventricular_Remodeling_is_an_Independent_Risk_for_Heart_Failure_Symptoms_in_Subjects_With_Preserved_Systolic_Function?f_ri=49633","dom_id":"work_34083012","summary":"s u m m a r y Background: Age has been shown to be related with increased vascular stiffness, cardiac structural alterations, and geometric remodeling. Data regarding the relationship between clinical heart failure (HF) symptoms and aging-related alterations of ventricular geometries are scarce. We therefore investigated this issue. Methods: We subsequently studied 1,577 participants without cardiovascular or chronic lung disorders. Echocardiography-defined cardiac structures and left ventricular (LV) geometries, including LV mass, relative wall thickness, and mass-to-volume ratio were all determined. Baseline clinical variables, medical histories, and functional impairment in terms of HF symptoms during exercise were all obtained. Multivariate bootstrapping derived odds ratio from various models were used to represent the independent predictors for HF. Results: Of all, 1,459 participants (age: 49.3 AE 10.8; 36% female) with normal ejection fraction (66.8 AE 4.7%) were enrolled in our study. Cardiac structural alterations, ventricular geometric remodeling, and diastolic dysfunction were significantly related to aging process, along with increasing cardiovascular morbidities and risk factors. After adjusting for confounders and LV mass, change in ventricular geometries in terms of mass-to-volume ratio remained an independent risk, whereas relative wall thickness had a borderline significance for HF symptoms (odds ratio: 2.79 and 1.04, p ¼ 0.047 and 0.08, respectively). Conclusion: Cardiac structure, function, and various ventricular remodeling patterns were age-related. Such remodeling process is not only associated with a higher incidence of cardiovascular morbidities but also more likely to develop HF symptoms, which are independent of clinical variables and LV mass.","downloadable_attachments":[{"id":54016702,"asset_id":34083012,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":488231,"first_name":"Chung-Lieh","last_name":"Hung","domain_name":"independent","page_name":"ChungLiehHung","display_name":"Chung-Lieh Hung","profile_url":"https://independent.academia.edu/ChungLiehHung?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2506,"name":"Gerontology","url":"https://www.academia.edu/Documents/in/Gerontology?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":88113,"name":"Left Ventricular Assist Device","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Assist_Device?f_ri=49633","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30893688" data-work_id="30893688" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30893688/Nurses_Knowledge_of_Heart_Failure_Self_Management">Nurses' Knowledge of Heart Failure Self-Management</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">and hospital performance measures used to ensure quality care. Nurses are often the primary providers of education to patients with HF. This study assessed nurses' knowledge of basic principles of HF self-management. The study surveyed 49... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30893688" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">and hospital performance measures used to ensure quality care. Nurses are often the primary providers of education to patients with HF. This study assessed nurses' knowledge of basic principles of HF self-management. The study surveyed 49 nurses who regularly provided care to patients with HF at a hospital in the southeastern United States. A 20-item, true/false survey was administered to participants. Mean HF self-management knowledge score was 15.97 (79.85% correct). Consistent with previous studies, nurses scored lowest on knowledge related to transient dizziness (16.3% answered correctly), daily weight monitoring (36.2% answered correctly), and asymptomatic hypotension (58.3% answered correctly). Findings confirm previous work suggesting that nurses may not be adequately prepared to educate patients with HF about self-management. (Prog Cardiovasc Nurs. 2007;22:190-195)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30893688" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a41278523c69ffc84ec98cf3d6b4cdf2" rel="nofollow" data-download="{"attachment_id":51319203,"asset_id":30893688,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51319203/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="15899868" href="https://uncg.academia.edu/LeslieDavis">Leslie Davis</a><script data-card-contents-for-user="15899868" type="text/json">{"id":15899868,"first_name":"Leslie","last_name":"Davis","domain_name":"uncg","page_name":"LeslieDavis","display_name":"Leslie Davis","profile_url":"https://uncg.academia.edu/LeslieDavis?f_ri=49633","photo":"https://0.academia-photos.com/15899868/4300496/4998908/s65_leslie.davis.jpg_oh_3c5b03f076219642420b3fc449aba9f7_oe_546d93c1___gda___1416421933_c8eff942b7f98a627fa2f24c206b4d2f"}</script></span></span></li><li class="js-paper-rank-work_30893688 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30893688"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30893688, container: ".js-paper-rank-work_30893688", }); });</script></li><li class="js-percentile-work_30893688 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30893688; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_30893688"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_30893688 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="30893688"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30893688; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30893688]").text(description); $(".js-view-count-work_30893688").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30893688").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30893688"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4413" rel="nofollow" href="https://www.academia.edu/Documents/in/Educational_Measurement">Educational Measurement</a>, <script data-card-contents-for-ri="4413" type="text/json">{"id":4413,"name":"Educational Measurement","url":"https://www.academia.edu/Documents/in/Educational_Measurement?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9590" rel="nofollow" href="https://www.academia.edu/Documents/in/Self_Care">Self Care</a>, <script data-card-contents-for-ri="9590" type="text/json">{"id":9590,"name":"Self Care","url":"https://www.academia.edu/Documents/in/Self_Care?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30893688]'), work: {"id":30893688,"title":"Nurses' Knowledge of Heart Failure Self-Management","created_at":"2017-01-12T07:23:28.279-08:00","url":"https://www.academia.edu/30893688/Nurses_Knowledge_of_Heart_Failure_Self_Management?f_ri=49633","dom_id":"work_30893688","summary":"and hospital performance measures used to ensure quality care. Nurses are often the primary providers of education to patients with HF. This study assessed nurses' knowledge of basic principles of HF self-management. The study surveyed 49 nurses who regularly provided care to patients with HF at a hospital in the southeastern United States. A 20-item, true/false survey was administered to participants. Mean HF self-management knowledge score was 15.97 (79.85% correct). Consistent with previous studies, nurses scored lowest on knowledge related to transient dizziness (16.3% answered correctly), daily weight monitoring (36.2% answered correctly), and asymptomatic hypotension (58.3% answered correctly). Findings confirm previous work suggesting that nurses may not be adequately prepared to educate patients with HF about self-management. (Prog Cardiovasc Nurs. 2007;22:190-195)","downloadable_attachments":[{"id":51319203,"asset_id":30893688,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":15899868,"first_name":"Leslie","last_name":"Davis","domain_name":"uncg","page_name":"LeslieDavis","display_name":"Leslie Davis","profile_url":"https://uncg.academia.edu/LeslieDavis?f_ri=49633","photo":"https://0.academia-photos.com/15899868/4300496/4998908/s65_leslie.davis.jpg_oh_3c5b03f076219642420b3fc449aba9f7_oe_546d93c1___gda___1416421933_c8eff942b7f98a627fa2f24c206b4d2f"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=49633","nofollow":true},{"id":4413,"name":"Educational Measurement","url":"https://www.academia.edu/Documents/in/Educational_Measurement?f_ri=49633","nofollow":true},{"id":9590,"name":"Self Care","url":"https://www.academia.edu/Documents/in/Self_Care?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring?f_ri=49633"},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633"},{"id":94214,"name":"Telemetry","url":"https://www.academia.edu/Documents/in/Telemetry?f_ri=49633"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=49633"},{"id":181467,"name":"Nursing Education and Research in Nursing","url":"https://www.academia.edu/Documents/in/Nursing_Education_and_Research_in_Nursing?f_ri=49633"},{"id":238658,"name":"Progress","url":"https://www.academia.edu/Documents/in/Progress?f_ri=49633"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=49633"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=49633"},{"id":615484,"name":"Hypotension","url":"https://www.academia.edu/Documents/in/Hypotension?f_ri=49633"},{"id":704648,"name":"Clinical Competence","url":"https://www.academia.edu/Documents/in/Clinical_Competence?f_ri=49633"},{"id":784431,"name":"Nursing Assessment","url":"https://www.academia.edu/Documents/in/Nursing_Assessment?f_ri=49633"},{"id":998123,"name":"Southeastern United States","url":"https://www.academia.edu/Documents/in/Southeastern_United_States?f_ri=49633"},{"id":1214764,"name":"Dizziness","url":"https://www.academia.edu/Documents/in/Dizziness?f_ri=49633"},{"id":2491318,"name":"Guideline Adherence","url":"https://www.academia.edu/Documents/in/Guideline_Adherence?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9270425" data-work_id="9270425" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9270425/Long_term_survival_after_aortic_valve_replacement_for_native_active_infective_endocarditis">Long-term survival after aortic valve replacement for native active infective endocarditis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-term prognosis after surgery. Methods: A total of 161 patients underwent aortic valve... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_9270425" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-term prognosis after surgery. Methods: A total of 161 patients underwent aortic valve replacement for native active aortic valve endocarditis (NAAVE) during a 29-year period, from 1967 to 1995 (age range: 10 to 72 years; mean 48 ± 12). The main indication for surgery was progressive congestive heart failure (76%). Other indications were unbeatable sepsis (27%), peripheral or central emboli (12%) and, from 1978, echocardiographic evidence of friable, pedunculated vegetations (3%). Streptococcal and staphylococcal infections predominated. Concomitant procedures were performed in 27% of the patients, including mitral and tricuspid valve surgery and coronary bypass procedures. Results: Operative mortality was 8% in the majority of cases caused by heart failure or multiorgan failure. Multivariate logistic regression analysis identified NYHA class IV to be an independent predictor for postoperative death. Long-term survival for discharged patients was 75% at 10 years and 58% at 15 years, with a mortality rate of 3.6%/patient/year. Cox regression analysis identified the year of operation, trivalvular endocarditis and staphylococcal infection as independent predictors of survival. At 10 and 15 years after aortic valve replacement, 91% and 84% of the patients, respectively, were free of recurrent endocarditis. The presence of an abscess cavity at first operation was found to be predictive of recurrent endocarditis. Conclusions: Valve replacement for NAAVE offers a good chance for a cure and satisfactory long-term survival. Improvements in pre- and per-op-rative management of the very ill patient, and the use of allograft valves are likely to further improve long-term results. Finally, the presence of staphylococcal endocarditis requires long-term postoperative antibiotic therapy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9270425" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0821bd88d17c60b676f720d23798368d" rel="nofollow" data-download="{"attachment_id":47835598,"asset_id":9270425,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47835598/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="21312840" href="https://independent.academia.edu/MohamedAmrani5">Mohamed Amrani</a><script data-card-contents-for-user="21312840" type="text/json">{"id":21312840,"first_name":"Mohamed","last_name":"Amrani","domain_name":"independent","page_name":"MohamedAmrani5","display_name":"Mohamed Amrani","profile_url":"https://independent.academia.edu/MohamedAmrani5?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9270425 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9270425"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9270425, container: ".js-paper-rank-work_9270425", }); });</script></li><li class="js-percentile-work_9270425 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 9270425; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_9270425"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_9270425 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="9270425"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 9270425; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=9270425]").text(description); $(".js-view-count-work_9270425").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_9270425").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="9270425"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4366" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiovascular">Cardiovascular</a>, <script data-card-contents-for-ri="4366" type="text/json">{"id":4366,"name":"Cardiovascular","url":"https://www.academia.edu/Documents/in/Cardiovascular?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="40862" rel="nofollow" href="https://www.academia.edu/Documents/in/Belgium">Belgium</a>, <script data-card-contents-for-ri="40862" type="text/json">{"id":40862,"name":"Belgium","url":"https://www.academia.edu/Documents/in/Belgium?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=9270425]'), work: {"id":9270425,"title":"Long-term survival after aortic valve replacement for native active infective endocarditis","created_at":"2014-11-12T04:55:36.968-08:00","url":"https://www.academia.edu/9270425/Long_term_survival_after_aortic_valve_replacement_for_native_active_infective_endocarditis?f_ri=49633","dom_id":"work_9270425","summary":"Background: The objective of this study was to analyse the impact of acute surgery for native aortic valve endocarditis and its influence on the long-term prognosis after surgery. Methods: A total of 161 patients underwent aortic valve replacement for native active aortic valve endocarditis (NAAVE) during a 29-year period, from 1967 to 1995 (age range: 10 to 72 years; mean 48 ± 12). The main indication for surgery was progressive congestive heart failure (76%). Other indications were unbeatable sepsis (27%), peripheral or central emboli (12%) and, from 1978, echocardiographic evidence of friable, pedunculated vegetations (3%). Streptococcal and staphylococcal infections predominated. Concomitant procedures were performed in 27% of the patients, including mitral and tricuspid valve surgery and coronary bypass procedures. Results: Operative mortality was 8% in the majority of cases caused by heart failure or multiorgan failure. Multivariate logistic regression analysis identified NYHA class IV to be an independent predictor for postoperative death. Long-term survival for discharged patients was 75% at 10 years and 58% at 15 years, with a mortality rate of 3.6%/patient/year. Cox regression analysis identified the year of operation, trivalvular endocarditis and staphylococcal infection as independent predictors of survival. At 10 and 15 years after aortic valve replacement, 91% and 84% of the patients, respectively, were free of recurrent endocarditis. The presence of an abscess cavity at first operation was found to be predictive of recurrent endocarditis. Conclusions: Valve replacement for NAAVE offers a good chance for a cure and satisfactory long-term survival. Improvements in pre- and per-op-rative management of the very ill patient, and the use of allograft valves are likely to further improve long-term results. Finally, the presence of staphylococcal endocarditis requires long-term postoperative antibiotic therapy.","downloadable_attachments":[{"id":47835598,"asset_id":9270425,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":21312840,"first_name":"Mohamed","last_name":"Amrani","domain_name":"independent","page_name":"MohamedAmrani5","display_name":"Mohamed Amrani","profile_url":"https://independent.academia.edu/MohamedAmrani5?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4366,"name":"Cardiovascular","url":"https://www.academia.edu/Documents/in/Cardiovascular?f_ri=49633","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true},{"id":40862,"name":"Belgium","url":"https://www.academia.edu/Documents/in/Belgium?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=49633"},{"id":75348,"name":"Cox Regression","url":"https://www.academia.edu/Documents/in/Cox_Regression?f_ri=49633"},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=49633"},{"id":212320,"name":"Logistic Regression Analysis","url":"https://www.academia.edu/Documents/in/Logistic_Regression_Analysis?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":358648,"name":"Infective Endocarditis","url":"https://www.academia.edu/Documents/in/Infective_Endocarditis?f_ri=49633"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=49633"},{"id":691300,"name":"CARDİOVASCULAR SURGERY","url":"https://www.academia.edu/Documents/in/CARD%C4%B0OVASCULAR_SURGERY?f_ri=49633"},{"id":1264978,"name":"Aortic Valve","url":"https://www.academia.edu/Documents/in/Aortic_Valve?f_ri=49633"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=49633"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=49633"},{"id":1680434,"name":"Mortality rate","url":"https://www.academia.edu/Documents/in/Mortality_rate?f_ri=49633"},{"id":2079289,"name":"Valve replacement","url":"https://www.academia.edu/Documents/in/Valve_replacement?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27309365" data-work_id="27309365" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27309365/Survival_and_complications_in_patients_with_thalassemia_major_treated_with_transfusion_and_deferoxamine">Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Seven Italian centers reported data on survival, causes of death and appearance of complications in patients with thalassemia major. The interactions between gender, birth cohort, complications, and ferritin on survival and complications... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27309365" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Seven Italian centers reported data on survival, causes of death and appearance of complications in patients with thalassemia major. The interactions between gender, birth cohort, complications, and ferritin on survival and complications were analyzed. Survival after the first decade was studied for 977 patients born since 1960 whereas survival since birth and complication appearance was studied for the 720 patients born after 1970. Better survival was demonstrated for patients born in more recent years (p&lt;0.00005) and for females (p=0.0003); 68% of the patients are alive at the age of 35 years. In the entire population 67% of the deaths were due to heart disease. There was a significant association between birth cohort and complication-free survival (p&lt;0.0005). The prevalence of complications was: heart failure 6.8%, arrhythmia 5.7%, hypogonadism 54.7%, hypothyroidism 10.8%, diabetes 6.4%, HIV infection 1.7%, and thrombosis 1.1%. Lower ferritin levels were associated with a l...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27309365" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1ad4cca42d6e34c97986fde51b7849ef" rel="nofollow" data-download="{"attachment_id":47565897,"asset_id":27309365,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47565897/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32905769" href="https://independent.academia.edu/GianForni">Gian Forni</a><script data-card-contents-for-user="32905769" type="text/json">{"id":32905769,"first_name":"Gian","last_name":"Forni","domain_name":"independent","page_name":"GianForni","display_name":"Gian Forni","profile_url":"https://independent.academia.edu/GianForni?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27309365 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27309365"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27309365, container: ".js-paper-rank-work_27309365", }); 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The interactions between gender, birth cohort, complications, and ferritin on survival and complications were analyzed. Survival after the first decade was studied for 977 patients born since 1960 whereas survival since birth and complication appearance was studied for the 720 patients born after 1970. Better survival was demonstrated for patients born in more recent years (p\u0026lt;0.00005) and for females (p=0.0003); 68% of the patients are alive at the age of 35 years. In the entire population 67% of the deaths were due to heart disease. There was a significant association between birth cohort and complication-free survival (p\u0026lt;0.0005). The prevalence of complications was: heart failure 6.8%, arrhythmia 5.7%, hypogonadism 54.7%, hypothyroidism 10.8%, diabetes 6.4%, HIV infection 1.7%, and thrombosis 1.1%. Lower ferritin levels were associated with a l...","downloadable_attachments":[{"id":47565897,"asset_id":27309365,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32905769,"first_name":"Gian","last_name":"Forni","domain_name":"independent","page_name":"GianForni","display_name":"Gian Forni","profile_url":"https://independent.academia.edu/GianForni?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7825,"name":"Thalassemia","url":"https://www.academia.edu/Documents/in/Thalassemia?f_ri=49633","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=49633","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":231186,"name":"Hypothyroidism","url":"https://www.academia.edu/Documents/in/Hypothyroidism?f_ri=49633"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=49633"},{"id":375034,"name":"Late onset hypogonadism","url":"https://www.academia.edu/Documents/in/Late_onset_hypogonadism?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=49633"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=49633"},{"id":627890,"name":"Blood Transfusion","url":"https://www.academia.edu/Documents/in/Blood_Transfusion?f_ri=49633"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=49633"},{"id":1491248,"name":"Life tables","url":"https://www.academia.edu/Documents/in/Life_tables?f_ri=49633"},{"id":1800451,"name":"Chelation Therapy","url":"https://www.academia.edu/Documents/in/Chelation_Therapy?f_ri=49633"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=49633"},{"id":2190600,"name":"Splenectomy","url":"https://www.academia.edu/Documents/in/Splenectomy?f_ri=49633"},{"id":2397637,"name":"Deferoxamine","url":"https://www.academia.edu/Documents/in/Deferoxamine?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11886950" data-work_id="11886950" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11886950/Role_of_proteases_in_the_pathophysiology_of_cardiac_disease">Role of proteases in the pathophysiology of cardiac disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cardiovascular disease is a major cause of death and thus a great deal of effort has been made in salvaging the diseased myocardium. Although various factors have been identified as possible causes of different cardiac diseases such as... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11886950" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cardiovascular disease is a major cause of death and thus a great deal of effort has been made in salvaging the diseased myocardium. Although various factors have been identified as possible causes of different cardiac diseases such as heart failure and ischemic heart disease, there is a real need to elucidate their role for the better understanding of the cardiac disease pathology and formulation of strategies for developing newer therapeutic interventions. In view of the intimate involvement of different types of proteases in maintaining cellular structure, the role of proteases in various cardiac diseases has become the focus of recent research. Proteases are present in the cytosol as well as are localized in a number of subcellular organelles in the cell. These are known to use extracellular matrix, cytoskeletal, sarcolemmal, sarcoplasmic reticular, mitochondrial and myofibrillar proteins as substrates. Work from different laboratories using a wide variety of techniques has shown that the activation of proteases causes alterations of a number of specific proteins leading to subcellular remodeling and cardiac dysfunction. Inhibition of protease action by different drugs and agents, therefore, has a clinical relevance and is expected to form a part of new treatment paradigm for improving heart function. This review examines the biochemistry and localization of some of the proteases in the cardiac tissue in addition to identification of the sites of action of some protease inhibitors. (Mol Cell Biochem 263: 241–256, 2004)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11886950" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6c1ab4be8801cdfe9d819ab69b2cc541" rel="nofollow" data-download="{"attachment_id":46458228,"asset_id":11886950,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46458228/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="29381160" href="https://independent.academia.edu/RajaSingh20">Raja Singh</a><script data-card-contents-for-user="29381160" type="text/json">{"id":29381160,"first_name":"Raja","last_name":"Singh","domain_name":"independent","page_name":"RajaSingh20","display_name":"Raja Singh","profile_url":"https://independent.academia.edu/RajaSingh20?f_ri=49633","photo":"https://0.academia-photos.com/29381160/8407857/9399911/s65_raja.singh.jpg"}</script></span></span></li><li class="js-paper-rank-work_11886950 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11886950"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11886950, container: ".js-paper-rank-work_11886950", }); 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Although various factors have been identified as possible causes of different cardiac diseases such as heart failure and ischemic heart disease, there is a real need to elucidate their role for the better understanding of the cardiac disease pathology and formulation of strategies for developing newer therapeutic interventions. In view of the intimate involvement of different types of proteases in maintaining cellular structure, the role of proteases in various cardiac diseases has become the focus of recent research. Proteases are present in the cytosol as well as are localized in a number of subcellular organelles in the cell. These are known to use extracellular matrix, cytoskeletal, sarcolemmal, sarcoplasmic reticular, mitochondrial and myofibrillar proteins as substrates. Work from different laboratories using a wide variety of techniques has shown that the activation of proteases causes alterations of a number of specific proteins leading to subcellular remodeling and cardiac dysfunction. Inhibition of protease action by different drugs and agents, therefore, has a clinical relevance and is expected to form a part of new treatment paradigm for improving heart function. This review examines the biochemistry and localization of some of the proteases in the cardiac tissue in addition to identification of the sites of action of some protease inhibitors. (Mol Cell Biochem 263: 241–256, 2004)","downloadable_attachments":[{"id":46458228,"asset_id":11886950,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":29381160,"first_name":"Raja","last_name":"Singh","domain_name":"independent","page_name":"RajaSingh20","display_name":"Raja Singh","profile_url":"https://independent.academia.edu/RajaSingh20?f_ri=49633","photo":"https://0.academia-photos.com/29381160/8407857/9399911/s65_raja.singh.jpg"}],"research_interests":[{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease?f_ri=49633","nofollow":true},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":63067,"name":"Molecular and cellular 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data-work_id="11979185" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11979185/Contraindications_to_metformin_therapy_in_patients_with_Type_2_diabetes_a_population_based_study_of_adherence_to_prescribing_guidelines">Contraindications to metformin therapy in patients with Type 2 diabetes—a population‐based study of adherence to prescribing guidelines</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aims To de®ne the number of people in Tayside, Scotland (population 349 303) with Type 2 diabetes who use metformin, the incidence of contraindications to its continued use in these people and the proportion that discontinued metformin... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_11979185" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aims To de®ne the number of people in Tayside, Scotland (population 349 303) with Type 2 diabetes who use metformin, the incidence of contraindications to its continued use in these people and the proportion that discontinued metformin treatment following the development of a contraindication.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11979185" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5c84527888257de59144d820a52b6207" rel="nofollow" data-download="{"attachment_id":46414011,"asset_id":11979185,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46414011/download_file?st=MTczOTgwNzY0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="29766291" href="https://independent.academia.edu/FrankSullivan4">Frank Sullivan</a><script data-card-contents-for-user="29766291" type="text/json">{"id":29766291,"first_name":"Frank","last_name":"Sullivan","domain_name":"independent","page_name":"FrankSullivan4","display_name":"Frank Sullivan","profile_url":"https://independent.academia.edu/FrankSullivan4?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11979185 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11979185"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11979185, container: ".js-paper-rank-work_11979185", }); });</script></li><li class="js-percentile-work_11979185 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11979185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11979185"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11979185 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11979185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11979185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11979185]").text(description); $(".js-view-count-work_11979185").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11979185").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11979185"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="25469" rel="nofollow" href="https://www.academia.edu/Documents/in/Family_Practice">Family Practice</a>, <script data-card-contents-for-ri="25469" type="text/json">{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47067" rel="nofollow" href="https://www.academia.edu/Documents/in/Liver_diseases">Liver diseases</a>, <script data-card-contents-for-ri="47067" type="text/json">{"id":47067,"name":"Liver diseases","url":"https://www.academia.edu/Documents/in/Liver_diseases?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71297" rel="nofollow" href="https://www.academia.edu/Documents/in/Metformin">Metformin</a><script data-card-contents-for-ri="71297" type="text/json">{"id":71297,"name":"Metformin","url":"https://www.academia.edu/Documents/in/Metformin?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11979185]'), work: {"id":11979185,"title":"Contraindications to metformin therapy in patients with Type 2 diabetes—a population‐based study of adherence to prescribing guidelines","created_at":"2015-04-16T17:09:47.737-07:00","url":"https://www.academia.edu/11979185/Contraindications_to_metformin_therapy_in_patients_with_Type_2_diabetes_a_population_based_study_of_adherence_to_prescribing_guidelines?f_ri=49633","dom_id":"work_11979185","summary":"Aims To de®ne the number of people in Tayside, Scotland (population 349 303) with Type 2 diabetes who use metformin, the incidence of contraindications to its continued use in these people and the proportion that discontinued metformin treatment following the development of a contraindication.","downloadable_attachments":[{"id":46414011,"asset_id":11979185,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":29766291,"first_name":"Frank","last_name":"Sullivan","domain_name":"independent","page_name":"FrankSullivan4","display_name":"Frank Sullivan","profile_url":"https://independent.academia.edu/FrankSullivan4?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=49633","nofollow":true},{"id":47067,"name":"Liver diseases","url":"https://www.academia.edu/Documents/in/Liver_diseases?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":71297,"name":"Metformin","url":"https://www.academia.edu/Documents/in/Metformin?f_ri=49633","nofollow":true},{"id":81559,"name":"Scotland","url":"https://www.academia.edu/Documents/in/Scotland?f_ri=49633"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics?f_ri=49633"},{"id":121179,"name":"Population based study","url":"https://www.academia.edu/Documents/in/Population_based_study?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction?f_ri=49633"},{"id":453923,"name":"Oral Hypoglycemic Agents","url":"https://www.academia.edu/Documents/in/Oral_Hypoglycemic_Agents?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus?f_ri=49633"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24460878" data-work_id="24460878" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24460878/Trends_in_mortality_from_acute_myocardial_infarction_in_the_Coronary_Care_Unit">Trends in mortality from acute myocardial infarction in the Coronary Care Unit</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: The treatment and outcome of acute myocardial infarction (AMI) has evolved greatly over the past few decades. We compared the mortality and complication rates of patients with AMI admitted to the Coronary Care Unit (CCU) in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24460878" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: The treatment and outcome of acute myocardial infarction (AMI) has evolved greatly over the past few decades. We compared the mortality and complication rates of patients with AMI admitted to the Coronary Care Unit (CCU) in 2002 to previously reported data. Materials and Methods: All data for AMI patients admitted to National Heart Centre CCU in 2002 were collected through the Singapore Cardiac Data Bank, including demographics, inhospital complications and mortality. These were compared to previous reports from the same institution in 1988, 1975 and 1967. Results: A total of 516 cases with AMI were identified. A higher proportion of patients were aged ≥ ≥ ≥ ≥ ≥70 years in 2002 (31.8%) compared to 1988 (25%), 1975 (11%) and 1967 (5.6%). Acute percutaneous transluminal coronary angioplasty (PTCA) was performed in 250 of 516 (48%) patients in 2002. The overall in-patient and age-standardised mortality was 14.7% and 10% respectively, compared to 20.6% and 17% respectively in 1988 (P = 0.06). For the 250 patients who underwent acute PTCA, overall mortality was 5.2% compared to 24% in those who did not (P <0.001). Common in-hospital complications included heart failure (38%), non-sustained ventricular tachycardia (8%), atrial fibrillation (8%) and complete heart block (6%). Age, heart failure, bundle branch block and sustained ventricular tachycardia were associated with higher mortality by univariate analysis. On multivariate analysis, older age, heart failure and the absence of percutaneous intervention were independently associated with higher mortality. Conclusion: In-hospital mortality for AMI patients admitted to the CCU declined from 1988 to 2002 despite a higher proportion of elderly patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24460878" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3e9ce9cc62d35b89e16d10abe0f736a4" rel="nofollow" data-download="{"attachment_id":44792283,"asset_id":24460878,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44792283/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47147388" href="https://duke-nus.academia.edu/AaronWong">Aaron Wong</a><script data-card-contents-for-user="47147388" type="text/json">{"id":47147388,"first_name":"Aaron","last_name":"Wong","domain_name":"duke-nus","page_name":"AaronWong","display_name":"Aaron Wong","profile_url":"https://duke-nus.academia.edu/AaronWong?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_24460878 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24460878"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24460878, container: ".js-paper-rank-work_24460878", }); });</script></li><li class="js-percentile-work_24460878 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24460878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24460878"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24460878 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24460878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24460878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24460878]").text(description); $(".js-view-count-work_24460878").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24460878").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24460878"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24377" rel="nofollow" href="https://www.academia.edu/Documents/in/Mortality">Mortality</a>, <script data-card-contents-for-ri="24377" type="text/json">{"id":24377,"name":"Mortality","url":"https://www.academia.edu/Documents/in/Mortality?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41482" rel="nofollow" href="https://www.academia.edu/Documents/in/Multivariate_Analysis">Multivariate Analysis</a>, <script data-card-contents-for-ri="41482" type="text/json">{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24460878]'), work: {"id":24460878,"title":"Trends in mortality from acute myocardial infarction in the Coronary Care Unit","created_at":"2016-04-16T06:47:40.799-07:00","url":"https://www.academia.edu/24460878/Trends_in_mortality_from_acute_myocardial_infarction_in_the_Coronary_Care_Unit?f_ri=49633","dom_id":"work_24460878","summary":"Introduction: The treatment and outcome of acute myocardial infarction (AMI) has evolved greatly over the past few decades. We compared the mortality and complication rates of patients with AMI admitted to the Coronary Care Unit (CCU) in 2002 to previously reported data. Materials and Methods: All data for AMI patients admitted to National Heart Centre CCU in 2002 were collected through the Singapore Cardiac Data Bank, including demographics, inhospital complications and mortality. These were compared to previous reports from the same institution in 1988, 1975 and 1967. Results: A total of 516 cases with AMI were identified. A higher proportion of patients were aged ≥ ≥ ≥ ≥ ≥70 years in 2002 (31.8%) compared to 1988 (25%), 1975 (11%) and 1967 (5.6%). Acute percutaneous transluminal coronary angioplasty (PTCA) was performed in 250 of 516 (48%) patients in 2002. The overall in-patient and age-standardised mortality was 14.7% and 10% respectively, compared to 20.6% and 17% respectively in 1988 (P = 0.06). For the 250 patients who underwent acute PTCA, overall mortality was 5.2% compared to 24% in those who did not (P \u003c0.001). Common in-hospital complications included heart failure (38%), non-sustained ventricular tachycardia (8%), atrial fibrillation (8%) and complete heart block (6%). Age, heart failure, bundle branch block and sustained ventricular tachycardia were associated with higher mortality by univariate analysis. On multivariate analysis, older age, heart failure and the absence of percutaneous intervention were independently associated with higher mortality. Conclusion: In-hospital mortality for AMI patients admitted to the CCU declined from 1988 to 2002 despite a higher proportion of elderly patients.","downloadable_attachments":[{"id":44792283,"asset_id":24460878,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47147388,"first_name":"Aaron","last_name":"Wong","domain_name":"duke-nus","page_name":"AaronWong","display_name":"Aaron Wong","profile_url":"https://duke-nus.academia.edu/AaronWong?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=49633","nofollow":true},{"id":24377,"name":"Mortality","url":"https://www.academia.edu/Documents/in/Mortality?f_ri=49633","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":130890,"name":"Atrial Fibrillation","url":"https://www.academia.edu/Documents/in/Atrial_Fibrillation?f_ri=49633"},{"id":172151,"name":"Acute Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Acute_Myocardial_Infarction?f_ri=49633"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology?f_ri=49633"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=49633"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=49633"},{"id":793339,"name":"Intensive Care Units","url":"https://www.academia.edu/Documents/in/Intensive_Care_Units?f_ri=49633"},{"id":901284,"name":"Hospital Mortality","url":"https://www.academia.edu/Documents/in/Hospital_Mortality?f_ri=49633"},{"id":1242166,"name":"Ventricular Tachycardia","url":"https://www.academia.edu/Documents/in/Ventricular_Tachycardia?f_ri=49633"},{"id":1548059,"name":"Critical Illness","url":"https://www.academia.edu/Documents/in/Critical_Illness?f_ri=49633"},{"id":1637400,"name":"Bundle Branch Block","url":"https://www.academia.edu/Documents/in/Bundle_Branch_Block?f_ri=49633"},{"id":1675693,"name":"Coronary Care Unit","url":"https://www.academia.edu/Documents/in/Coronary_Care_Unit?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15018266" data-work_id="15018266" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15018266/The_influence_of_the_recipients_body_weight_on_the_probability_to_obtain_a_heart_transplant_POLKARD_HF_registry">The influence of the recipient's body weight on the probability to obtain a heart transplant-POLKARD HF registry</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of the study was to analyze the influence of body weight of the adult heart recipient on the chance to obtain a transplant. We analyzed the data from all 658 patients listed for heart transplantation. During the follow-up period,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15018266" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of the study was to analyze the influence of body weight of the adult heart recipient on the chance to obtain a transplant. We analyzed the data from all 658 patients listed for heart transplantation. During the follow-up period, 325 (49%) of listed patients underwent transplantation with 102 (15%) succumbing before heart transplantation. The mean weight of transplanted patients was 73.7 +/- 13.7 kg and 81.2 +/- 15.4 kg for those not transplanted (P &lt; .00001). Patients were divided according to body weight in two groups: light = below 80 kg (n = 360) or heavy &gt; or = 80 kg or above (n = 297). On the transplant list, 111 heavy patients (37%) versus 213 light patients (59%) underwent the procedure, a significant difference. The waiting time among light patients was 255 versus heavy patients of 395 days (P &lt; .005). There was a similar number of deaths before transplantation among the light (n = 56 360 patients; 15.5%) versus the heavy group (49/297; 16%). Upon multivari...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15018266" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b3d5e343c23e91d6138b8dacd8f778d0" rel="nofollow" data-download="{"attachment_id":43652997,"asset_id":15018266,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43652997/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34021810" href="https://independent.academia.edu/JerzySadowski">Jerzy Sadowski</a><script data-card-contents-for-user="34021810" type="text/json">{"id":34021810,"first_name":"Jerzy","last_name":"Sadowski","domain_name":"independent","page_name":"JerzySadowski","display_name":"Jerzy Sadowski","profile_url":"https://independent.academia.edu/JerzySadowski?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15018266 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15018266"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15018266, container: ".js-paper-rank-work_15018266", }); 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We analyzed the data from all 658 patients listed for heart transplantation. During the follow-up period, 325 (49%) of listed patients underwent transplantation with 102 (15%) succumbing before heart transplantation. The mean weight of transplanted patients was 73.7 +/- 13.7 kg and 81.2 +/- 15.4 kg for those not transplanted (P \u0026lt; .00001). Patients were divided according to body weight in two groups: light = below 80 kg (n = 360) or heavy \u0026gt; or = 80 kg or above (n = 297). On the transplant list, 111 heavy patients (37%) versus 213 light patients (59%) underwent the procedure, a significant difference. The waiting time among light patients was 255 versus heavy patients of 395 days (P \u0026lt; .005). There was a similar number of deaths before transplantation among the light (n = 56 360 patients; 15.5%) versus the heavy group (49/297; 16%). Upon multivari...","downloadable_attachments":[{"id":43652997,"asset_id":15018266,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34021810,"first_name":"Jerzy","last_name":"Sadowski","domain_name":"independent","page_name":"JerzySadowski","display_name":"Jerzy Sadowski","profile_url":"https://independent.academia.edu/JerzySadowski?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":27363,"name":"Poland","url":"https://www.academia.edu/Documents/in/Poland?f_ri=49633","nofollow":true},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":63375,"name":"Overweight","url":"https://www.academia.edu/Documents/in/Overweight?f_ri=49633","nofollow":true},{"id":82641,"name":"Survivors","url":"https://www.academia.edu/Documents/in/Survivors?f_ri=49633"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=49633"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate?f_ri=49633"},{"id":209856,"name":"Registries","url":"https://www.academia.edu/Documents/in/Registries?f_ri=49633"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=49633"},{"id":543452,"name":"Thinness","url":"https://www.academia.edu/Documents/in/Thinness?f_ri=49633"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=49633"},{"id":892682,"name":"Body Height","url":"https://www.academia.edu/Documents/in/Body_Height?f_ri=49633"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=49633"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15621753 coauthored" data-work_id="15621753" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15621753/Relation_of_B_Type_Natriuretic_Peptide_Level_in_Heart_Failure_to_Sudden_Cardiac_Death_in_Patients_With_and_Without_QT_Interval_Prolongation">Relation of B-Type Natriuretic Peptide Level in Heart Failure to Sudden Cardiac Death in Patients With and Without QT Interval Prolongation</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15621753" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="da1d2f2230aeed5b2e3ca0227a9822e0" rel="nofollow" data-download="{"attachment_id":43026508,"asset_id":15621753,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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href="https://www.academia.edu/Documents/in/Electrocardiography">Electrocardiography</a>, <script data-card-contents-for-ri="39000" type="text/json">{"id":39000,"name":"Electrocardiography","url":"https://www.academia.edu/Documents/in/Electrocardiography?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46824" rel="nofollow" href="https://www.academia.edu/Documents/in/Echocardiography">Echocardiography</a>, <script data-card-contents-for-ri="46824" type="text/json">{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a 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Prolongation","created_at":"2015-09-12T01:52:20.460-07:00","url":"https://www.academia.edu/15621753/Relation_of_B_Type_Natriuretic_Peptide_Level_in_Heart_Failure_to_Sudden_Cardiac_Death_in_Patients_With_and_Without_QT_Interval_Prolongation?f_ri=49633","dom_id":"work_15621753","summary":null,"downloadable_attachments":[{"id":43026508,"asset_id":15621753,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34796747,"first_name":"Gregor","last_name":"Poglajen","domain_name":"independent","page_name":"GregorPoglajen","display_name":"Gregor Poglajen","profile_url":"https://independent.academia.edu/GregorPoglajen?f_ri=49633","photo":"/images/s65_no_pic.png"},{"id":34834404,"first_name":"Ivan","last_name":"Knezevic","domain_name":"independent","page_name":"IvanKnezevic1","display_name":"Ivan 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class="clearfix u-pv7x u-mb0x js-work-card work_21291196" data-work_id="21291196" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21291196/Pre_dialysis_clinic_attendance_improves_quality_of_life_among_hemodialysis_patients">Pre-dialysis clinic attendance improves quality of life among hemodialysis patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although previous research has demonstrated that referral to pre-dialysis clinics is associated with favourable objective outcomes, the benefit of a pre-dialysis clinic from the perspective of patient-perceived subjective outcomes, such... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21291196" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although previous research has demonstrated that referral to pre-dialysis clinics is associated with favourable objective outcomes, the benefit of a pre-dialysis clinic from the perspective of patient-perceived subjective outcomes, such as quality of life (QOL), is less well defined. A retrospective incident cohort study was conducted to determine if pre-dialysis clinic attendance was a predictor of better QOL scores measured within the first six months of hemodialysis (HD) initiation. Inclusion criteria were HD initiation from January 1 1998 to January 1 2000, diagnosis of chronic renal failure, and completion of the QOL questionnaire within six months of HD initiation. Patients receiving HD for less than four weeks were excluded. An incident cohort of 120 dialysis patients was identified, including 74 patients who attended at least one pre-dialysis clinic and 46 patients who did not. QOL was measured using the SF 36-Item Health Survey. Independent variables included age, sex, diab...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21291196" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1d7640f1bfe5aa582df6c375f58dfdbe" rel="nofollow" data-download="{"attachment_id":41801580,"asset_id":21291196,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41801580/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="336458" href="https://westernu.academia.edu/ChristineWhite">Christine White</a><script data-card-contents-for-user="336458" type="text/json">{"id":336458,"first_name":"Christine","last_name":"White","domain_name":"westernu","page_name":"ChristineWhite","display_name":"Christine White","profile_url":"https://westernu.academia.edu/ChristineWhite?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21291196 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21291196"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21291196, container: ".js-paper-rank-work_21291196", }); });</script></li><li class="js-percentile-work_21291196 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21291196; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21291196"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21291196 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21291196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21291196; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21291196]").text(description); $(".js-view-count-work_21291196").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21291196").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21291196"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41482" rel="nofollow" href="https://www.academia.edu/Documents/in/Multivariate_Analysis">Multivariate Analysis</a>, <script data-card-contents-for-ri="41482" type="text/json">{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="101212" rel="nofollow" href="https://www.academia.edu/Documents/in/Hemodialysis">Hemodialysis</a><script data-card-contents-for-ri="101212" type="text/json">{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21291196]'), work: {"id":21291196,"title":"Pre-dialysis clinic attendance improves quality of life among hemodialysis patients","created_at":"2016-01-31T04:18:05.850-08:00","url":"https://www.academia.edu/21291196/Pre_dialysis_clinic_attendance_improves_quality_of_life_among_hemodialysis_patients?f_ri=49633","dom_id":"work_21291196","summary":"Although previous research has demonstrated that referral to pre-dialysis clinics is associated with favourable objective outcomes, the benefit of a pre-dialysis clinic from the perspective of patient-perceived subjective outcomes, such as quality of life (QOL), is less well defined. A retrospective incident cohort study was conducted to determine if pre-dialysis clinic attendance was a predictor of better QOL scores measured within the first six months of hemodialysis (HD) initiation. Inclusion criteria were HD initiation from January 1 1998 to January 1 2000, diagnosis of chronic renal failure, and completion of the QOL questionnaire within six months of HD initiation. Patients receiving HD for less than four weeks were excluded. An incident cohort of 120 dialysis patients was identified, including 74 patients who attended at least one pre-dialysis clinic and 46 patients who did not. QOL was measured using the SF 36-Item Health Survey. Independent variables included age, sex, diab...","downloadable_attachments":[{"id":41801580,"asset_id":21291196,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":336458,"first_name":"Christine","last_name":"White","domain_name":"westernu","page_name":"ChristineWhite","display_name":"Christine White","profile_url":"https://westernu.academia.edu/ChristineWhite?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=49633","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis?f_ri=49633","nofollow":true},{"id":131185,"name":"Cohort Study","url":"https://www.academia.edu/Documents/in/Cohort_Study?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":267579,"name":"General Health","url":"https://www.academia.edu/Documents/in/General_Health?f_ri=49633"},{"id":290332,"name":"Chronic Renal Failure","url":"https://www.academia.edu/Documents/in/Chronic_Renal_Failure?f_ri=49633"},{"id":329135,"name":"Social Functioning","url":"https://www.academia.edu/Documents/in/Social_Functioning?f_ri=49633"},{"id":350855,"name":"Peripheral Vascular Disease","url":"https://www.academia.edu/Documents/in/Peripheral_Vascular_Disease?f_ri=49633"},{"id":395473,"name":"Patient Care Team","url":"https://www.academia.edu/Documents/in/Patient_Care_Team?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":659547,"name":"Ischemic Heart Disease","url":"https://www.academia.edu/Documents/in/Ischemic_Heart_Disease?f_ri=49633"},{"id":883945,"name":"Chronic lung disease","url":"https://www.academia.edu/Documents/in/Chronic_lung_disease?f_ri=49633"},{"id":1115362,"name":"Physical Function","url":"https://www.academia.edu/Documents/in/Physical_Function?f_ri=49633"},{"id":1265252,"name":"Health Survey","url":"https://www.academia.edu/Documents/in/Health_Survey?f_ri=49633"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20828549" data-work_id="20828549" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20828549/A_multicenter_analysis_of_the_ED_diagnosis_of_pneumonia">A multicenter analysis of the ED diagnosis of pneumonia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives: The objective of this study was to describe the prevalence of pneumonia-like signs and symptoms in patients admitted from the emergency department (ED) with a diagnosis of community acquired pneumonia (CAP) but subsequently... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_20828549" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives: The objective of this study was to describe the prevalence of pneumonia-like signs and symptoms in patients admitted from the emergency department (ED) with a diagnosis of community acquired pneumonia (CAP) but subsequently discharged from the hospital with a nonpneumonia diagnosis. Methods: A retrospective, structured, chart review of ED patients with CAP at 3 academic hospitals was performed by trained extractors on all adult patients admitted for CAP. Demographic data, Pneumonia Patient Outcomes Research Team scores, and discharge diagnosis data (International Classification of Diseases, Ninth Revision [ICD-9] codes) were extracted using a predetermined case report form. Results: A total of 800 patients were admitted from the ED with a diagnosis of CAP from the 3 hospitals, and 219 (27.3%; 95% confidence interval [CI], 24-31) ultimately had a nonpneumonia diagnosis upon discharge. Characteristics of this group included a mean age of 62.6 years, 50% female, and a history of congestive heart failure (CHF) (14%) or cancer (12%). After excluding patients with missing data, 123 patients (65%) had an abnormal chest x-ray, and 13% had abnormal oxygen saturation. Cough, sputum production, fever, tachypnea, or leukocytosis were present in 91.5% of this cohort, and 63.8% had at least 2 of these findings. Twenty alternate ICD-9s were identified, including non-CAP pulmonary disease (18%; 95% CI, 13-24), renal disease (16%; 95% CI, 13-19), other infections (9%; 95% CI, 7-11), cardiovascular diseases (3%; 95% CI, 2-4), and other miscellaneous diagnosis (28%; 95% CI, 25-31). Conclusions: Our data suggest that the ED diagnosis of CAP frequently differs from the discharge diagnosis. This may be due to the fact that a diagnosis of CAP relies on a combination of potentially nonspecific clinical and radiographic features. New diagnostic approaches and tools with better specificity are needed to improve ED diagnosis of CAP.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20828549" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0dfa9d29b73489c0a939da75d07de32b" rel="nofollow" data-download="{"attachment_id":41585097,"asset_id":20828549,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41585097/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42125650" href="https://duke.academia.edu/AlexLimkakeng">Alex Limkakeng</a><script data-card-contents-for-user="42125650" type="text/json">{"id":42125650,"first_name":"Alex","last_name":"Limkakeng","domain_name":"duke","page_name":"AlexLimkakeng","display_name":"Alex Limkakeng","profile_url":"https://duke.academia.edu/AlexLimkakeng?f_ri=49633","photo":"https://0.academia-photos.com/42125650/27530181/25866687/s65_alex.limkakeng.jpeg"}</script></span></span></li><li class="js-paper-rank-work_20828549 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="20828549"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 20828549, container: ".js-paper-rank-work_20828549", }); });</script></li><li class="js-percentile-work_20828549 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20828549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_20828549"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_20828549 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="20828549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20828549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20828549]").text(description); $(".js-view-count-work_20828549").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_20828549").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="20828549"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="96213" rel="nofollow" href="https://www.academia.edu/Documents/in/Hospitalization">Hospitalization</a>, <script data-card-contents-for-ri="96213" type="text/json">{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="111112" rel="nofollow" href="https://www.academia.edu/Documents/in/Pneumonia">Pneumonia</a>, <script data-card-contents-for-ri="111112" type="text/json">{"id":111112,"name":"Pneumonia","url":"https://www.academia.edu/Documents/in/Pneumonia?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="115488" rel="nofollow" href="https://www.academia.edu/Documents/in/Lung_Diseases">Lung Diseases</a><script data-card-contents-for-ri="115488" type="text/json">{"id":115488,"name":"Lung Diseases","url":"https://www.academia.edu/Documents/in/Lung_Diseases?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=20828549]'), work: {"id":20828549,"title":"A multicenter analysis of the ED diagnosis of pneumonia","created_at":"2016-01-26T04:36:13.069-08:00","url":"https://www.academia.edu/20828549/A_multicenter_analysis_of_the_ED_diagnosis_of_pneumonia?f_ri=49633","dom_id":"work_20828549","summary":"Objectives: The objective of this study was to describe the prevalence of pneumonia-like signs and symptoms in patients admitted from the emergency department (ED) with a diagnosis of community acquired pneumonia (CAP) but subsequently discharged from the hospital with a nonpneumonia diagnosis. Methods: A retrospective, structured, chart review of ED patients with CAP at 3 academic hospitals was performed by trained extractors on all adult patients admitted for CAP. Demographic data, Pneumonia Patient Outcomes Research Team scores, and discharge diagnosis data (International Classification of Diseases, Ninth Revision [ICD-9] codes) were extracted using a predetermined case report form. Results: A total of 800 patients were admitted from the ED with a diagnosis of CAP from the 3 hospitals, and 219 (27.3%; 95% confidence interval [CI], 24-31) ultimately had a nonpneumonia diagnosis upon discharge. Characteristics of this group included a mean age of 62.6 years, 50% female, and a history of congestive heart failure (CHF) (14%) or cancer (12%). After excluding patients with missing data, 123 patients (65%) had an abnormal chest x-ray, and 13% had abnormal oxygen saturation. Cough, sputum production, fever, tachypnea, or leukocytosis were present in 91.5% of this cohort, and 63.8% had at least 2 of these findings. Twenty alternate ICD-9s were identified, including non-CAP pulmonary disease (18%; 95% CI, 13-24), renal disease (16%; 95% CI, 13-19), other infections (9%; 95% CI, 7-11), cardiovascular diseases (3%; 95% CI, 2-4), and other miscellaneous diagnosis (28%; 95% CI, 25-31). Conclusions: Our data suggest that the ED diagnosis of CAP frequently differs from the discharge diagnosis. This may be due to the fact that a diagnosis of CAP relies on a combination of potentially nonspecific clinical and radiographic features. New diagnostic approaches and tools with better specificity are needed to improve ED diagnosis of CAP.","downloadable_attachments":[{"id":41585097,"asset_id":20828549,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42125650,"first_name":"Alex","last_name":"Limkakeng","domain_name":"duke","page_name":"AlexLimkakeng","display_name":"Alex Limkakeng","profile_url":"https://duke.academia.edu/AlexLimkakeng?f_ri=49633","photo":"https://0.academia-photos.com/42125650/27530181/25866687/s65_alex.limkakeng.jpeg"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633","nofollow":true},{"id":111112,"name":"Pneumonia","url":"https://www.academia.edu/Documents/in/Pneumonia?f_ri=49633","nofollow":true},{"id":115488,"name":"Lung Diseases","url":"https://www.academia.edu/Documents/in/Lung_Diseases?f_ri=49633","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":571425,"name":"Oximetry","url":"https://www.academia.edu/Documents/in/Oximetry?f_ri=49633"},{"id":626159,"name":"Community Acquired Pneumonia","url":"https://www.academia.edu/Documents/in/Community_Acquired_Pneumonia?f_ri=49633"},{"id":724400,"name":"Sputum","url":"https://www.academia.edu/Documents/in/Sputum?f_ri=49633"},{"id":1435137,"name":"Emergency Department","url":"https://www.academia.edu/Documents/in/Emergency_Department?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19925628 coauthored" data-work_id="19925628" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19925628/Ontologies_supporting_continuity_of_care_The_case_of_heart_failure">Ontologies supporting continuity of care: The case of heart failure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Heart failure can be the final stage of almost any type of cardiovascular diseases. Such diseases are the leading cause of recurrent hospital stay and mortality in developed countries, and an increasingly important cause of morbidity and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19925628" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Heart failure can be the final stage of almost any type of cardiovascular diseases. Such diseases are the leading cause of recurrent hospital stay and mortality in developed countries, and an increasingly important cause of morbidity and mortality in developing countries. In consideration of the growing incidence of this syndrome, the Province of Trento (Northern Italy) supports a research project called e-Heart Failure. The aims of this project include the implementation of a web-based patient record management system which must allow all the professionals involved in the care process to provide a shared and continuous care. This paper emphasizes the role of ontologies in supporting the continuity of care. In a complex scenario where multiple agents co-operate in order to allow continuity of care, ontologies are the essential glue to ensure semantic consistency to data and knowledge shared by the different actors involved in the process, including patients and their families.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19925628" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3fe123efcd103dd08ac734613b6e5eb7" rel="nofollow" data-download="{"attachment_id":40919034,"asset_id":19925628,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40919034/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40779341" href="https://cnr-it.academia.edu/DomenicoPisanelli">Domenico Pisanelli</a><script data-card-contents-for-user="40779341" type="text/json">{"id":40779341,"first_name":"Domenico","last_name":"Pisanelli","domain_name":"cnr-it","page_name":"DomenicoPisanelli","display_name":"Domenico Pisanelli","profile_url":"https://cnr-it.academia.edu/DomenicoPisanelli?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-19925628">+1</span><div class="hidden js-additional-users-19925628"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://fbk.academia.edu/ClaudioEccher">Claudio Eccher</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-19925628'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-19925628').html(); 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Such diseases are the leading cause of recurrent hospital stay and mortality in developed countries, and an increasingly important cause of morbidity and mortality in developing countries. In consideration of the growing incidence of this syndrome, the Province of Trento (Northern Italy) supports a research project called e-Heart Failure. The aims of this project include the implementation of a web-based patient record management system which must allow all the professionals involved in the care process to provide a shared and continuous care. This paper emphasizes the role of ontologies in supporting the continuity of care. In a complex scenario where multiple agents co-operate in order to allow continuity of care, ontologies are the essential glue to ensure semantic consistency to data and knowledge shared by the different actors involved in the process, including patients and their families.","downloadable_attachments":[{"id":40919034,"asset_id":19925628,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40779341,"first_name":"Domenico","last_name":"Pisanelli","domain_name":"cnr-it","page_name":"DomenicoPisanelli","display_name":"Domenico Pisanelli","profile_url":"https://cnr-it.academia.edu/DomenicoPisanelli?f_ri=49633","photo":"/images/s65_no_pic.png"},{"id":24855356,"first_name":"Claudio","last_name":"Eccher","domain_name":"fbk","page_name":"ClaudioEccher","display_name":"Claudio Eccher","profile_url":"https://fbk.academia.edu/ClaudioEccher?f_ri=49633","photo":"https://0.academia-photos.com/24855356/6726893/7598083/s65_claudio.eccher.jpg_oh_ca47598a104652e4b01ece68ec83a346_oe_5521730a___gda___1432739739_dfc04e4acce17138d3991c37ca77d679"}],"research_interests":[{"id":1212,"name":"Medical Informatics","url":"https://www.academia.edu/Documents/in/Medical_Informatics?f_ri=49633","nofollow":true},{"id":3419,"name":"Multimedia","url":"https://www.academia.edu/Documents/in/Multimedia?f_ri=49633","nofollow":true},{"id":5527,"name":"Knowledge sharing","url":"https://www.academia.edu/Documents/in/Knowledge_sharing?f_ri=49633","nofollow":true},{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease?f_ri=49633","nofollow":true},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=49633"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=49633"},{"id":130698,"name":"Continuity of Care","url":"https://www.academia.edu/Documents/in/Continuity_of_Care?f_ri=49633"},{"id":290799,"name":"Management System","url":"https://www.academia.edu/Documents/in/Management_System?f_ri=49633"},{"id":1034177,"name":"Continuity of Patient Care","url":"https://www.academia.edu/Documents/in/Continuity_of_Patient_Care?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18604575" data-work_id="18604575" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18604575/Effect_of_tricuspid_regurgitation_on_the_reliability_of_the_thermodilution_cardiac_output_technique_in_congestive_heart_failure">Effect of tricuspid regurgitation on the reliability of the thermodilution cardiac output technique in congestive heart failure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">... Effect of Tricuspid Regurgttation on the Reliability of the Thermodilution Cardiac Output Technique in Congestive Heart Failure Michele A. Hamilton, MD, Lynne W. Stevenson, MD, Mary Woo, RN,John S. Child, MD ... 6. Rubin SA,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18604575" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">... Effect of Tricuspid Regurgttation on the Reliability of the Thermodilution Cardiac Output Technique in Congestive Heart Failure Michele A. Hamilton, MD, Lynne W. Stevenson, MD, Mary Woo, RN,John S. Child, MD ... 6. Rubin SA, Siemienczuk D, Nathan MD, Prause J, Swan HJC. ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18604575" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8864d0ad51f2b98be188501c9b58eb52" rel="nofollow" data-download="{"attachment_id":42152100,"asset_id":18604575,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42152100/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38648213" href="https://independent.academia.edu/LynneStevenson">Lynne Stevenson</a><script data-card-contents-for-user="38648213" type="text/json">{"id":38648213,"first_name":"Lynne","last_name":"Stevenson","domain_name":"independent","page_name":"LynneStevenson","display_name":"Lynne Stevenson","profile_url":"https://independent.academia.edu/LynneStevenson?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18604575 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18604575"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18604575, container: ".js-paper-rank-work_18604575", }); 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$(".js-view-count[data-work-id=18604575]").text(description); $(".js-view-count-work_18604575").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18604575").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18604575"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88114" rel="nofollow" href="https://www.academia.edu/Documents/in/Congestive_Heart_Failure">Congestive Heart Failure</a>, <script data-card-contents-for-ri="88114" type="text/json">{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" rel="nofollow" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18604575]'), work: {"id":18604575,"title":"Effect of tricuspid regurgitation on the reliability of the thermodilution cardiac output technique in congestive heart failure","created_at":"2015-11-18T13:02:03.215-08:00","url":"https://www.academia.edu/18604575/Effect_of_tricuspid_regurgitation_on_the_reliability_of_the_thermodilution_cardiac_output_technique_in_congestive_heart_failure?f_ri=49633","dom_id":"work_18604575","summary":"... Effect of Tricuspid Regurgttation on the Reliability of the Thermodilution Cardiac Output Technique in Congestive Heart Failure Michele A. Hamilton, MD, Lynne W. Stevenson, MD, Mary Woo, RN,John S. Child, MD ... 6. Rubin SA, Siemienczuk D, Nathan MD, Prause J, Swan HJC. ...","downloadable_attachments":[{"id":42152100,"asset_id":18604575,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38648213,"first_name":"Lynne","last_name":"Stevenson","domain_name":"independent","page_name":"LynneStevenson","display_name":"Lynne Stevenson","profile_url":"https://independent.academia.edu/LynneStevenson?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633","nofollow":true},{"id":426578,"name":"Cardiac Output Monitoring","url":"https://www.academia.edu/Documents/in/Cardiac_Output_Monitoring?f_ri=49633"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=49633"},{"id":1730761,"name":"Tricuspid Regurgitation","url":"https://www.academia.edu/Documents/in/Tricuspid_Regurgitation?f_ri=49633"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13672068" data-work_id="13672068" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13672068/Knowledge_expectations_and_health_of_CR_T_patients">Knowledge expectations and health of CR T patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Conclusion: Heart failure patients waiting for a CRT device implantation have high expectations for multiple aspects of knowledge, including self-care issues, before their procedure. Read this original research and sign up to receive... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13672068" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Conclusion: Heart failure patients waiting for a CRT device implantation have high expectations for multiple aspects of knowledge, including self-care issues, before their procedure. <br /> <br />Read this original research and sign up to receive Patient Preference and Adherence journal here: <a href="http://www.dovepress.com/articles.php?article_id=22443" rel="nofollow">http://www.dovepress.com/articles.php?article_id=22443</a></div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13672068" data-share-source="work_strip" 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var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13672068]").text(description); $(".js-view-count-work_13672068").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13672068").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13672068"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52710" rel="nofollow" href="https://www.academia.edu/Documents/in/Patient_education">Patient education</a>, <script data-card-contents-for-ri="52710" type="text/json">{"id":52710,"name":"Patient education","url":"https://www.academia.edu/Documents/in/Patient_education?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="161518" rel="nofollow" href="https://www.academia.edu/Documents/in/Patient_Preference">Patient Preference</a>, <script data-card-contents-for-ri="161518" type="text/json">{"id":161518,"name":"Patient Preference","url":"https://www.academia.edu/Documents/in/Patient_Preference?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="462474" rel="nofollow" href="https://www.academia.edu/Documents/in/Adherence">Adherence</a><script data-card-contents-for-ri="462474" type="text/json">{"id":462474,"name":"Adherence","url":"https://www.academia.edu/Documents/in/Adherence?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13672068]'), work: {"id":13672068,"title":"Knowledge expectations and health of CR T patients","created_at":"2015-07-05T17:24:18.783-07:00","url":"https://www.academia.edu/13672068/Knowledge_expectations_and_health_of_CR_T_patients?f_ri=49633","dom_id":"work_13672068","summary":"Conclusion: Heart failure patients waiting for a CRT device implantation have high expectations for multiple aspects of knowledge, including self-care issues, before their procedure.\r\n\r\nRead this original research and sign up to receive Patient Preference and Adherence journal here: http://www.dovepress.com/articles.php?article_id=22443","downloadable_attachments":[{"id":38100287,"asset_id":13672068,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4281291,"first_name":"Dove Medical","last_name":"Press","domain_name":"dovepress","page_name":"AdieChan","display_name":"Dove Medical Press","profile_url":"https://dovepress.academia.edu/AdieChan?f_ri=49633","photo":"https://0.academia-photos.com/4281291/1704374/2044736/s65_albert.chan.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":52710,"name":"Patient education","url":"https://www.academia.edu/Documents/in/Patient_education?f_ri=49633","nofollow":true},{"id":161518,"name":"Patient Preference","url":"https://www.academia.edu/Documents/in/Patient_Preference?f_ri=49633","nofollow":true},{"id":462474,"name":"Adherence","url":"https://www.academia.edu/Documents/in/Adherence?f_ri=49633","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76977573 coauthored" data-work_id="76977573" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/76977573/COST_EFFECTIVENESS_OF_SACUBITRIL_VALSARTAN_COMPARED_TO_ANGIOTENSIN_CONVERTING_ENZYME_INHIBITORS_IN_PATIENTS_WITH_HEART_FAILURE_WITH_REDUCED_EJECTION_FRACTION">COST-EFFECTIVENESS OF SACUBITRIL–VALSARTAN COMPARED TO ANGIOTENSIN-CONVERTING ENZYME INHIBITORS IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives: The goal of this study was to compare cost-effectiveness of sacubitril/valsartan with angiotensin-converting enzyme (ACE) inhibitors for treating chronic heart failure patients with reduced ejection fraction (HFrEF) from the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_76977573" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives: The goal of this study was to compare cost-effectiveness of sacubitril/valsartan with angiotensin-converting enzyme (ACE) inhibitors for treating chronic heart failure patients with reduced ejection fraction (HFrEF) from the published articles and explore the methodology applied in the studies.<br />Methods: Systematic research was conducted in February 2021 using PubMed, Cochrane, and EBSCO. A combination of MeSH terms of ‘cost-effectiveness analysis’, ‘heart failure with reduced ejection fraction’, ‘sacubitril valsartan’ and ‘angiotensin converting enzyme inhibitor’ was employed. The review selected for articles published in the last five years in English. <br />Results: A total of 15 studies were included in this review. We found that the studies had been conducted in 12 different countries. The United States had the greatest number of publications (5), followed by the Netherlands (2). The study method most used was the Markov decision model (73%). Almost all studies produced ICERs and QALYs that were numerically high.<br />Conclusions: The use of sacubitril/valsartan associates with longer life expectancy and incremental cost-effectiveness ratio than angiotensin-converting enzyme inhibitors.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76977573" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c3fa907448a6228f19529a20434750f2" rel="nofollow" data-download="{"attachment_id":84519138,"asset_id":76977573,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/84519138/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="98064718" href="https://uns-id.academia.edu/StefanusErdanaPutra">Stefanus Erdana Putra</a><script data-card-contents-for-user="98064718" type="text/json">{"id":98064718,"first_name":"Stefanus Erdana","last_name":"Putra","domain_name":"uns-id","page_name":"StefanusErdanaPutra","display_name":"Stefanus Erdana Putra","profile_url":"https://uns-id.academia.edu/StefanusErdanaPutra?f_ri=49633","photo":"https://0.academia-photos.com/98064718/21848360/35507648/s65_stefanus_erdana.putra.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-76977573">+1</span><div class="hidden js-additional-users-76977573"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/RatihPuspitaFebrinasari">Ratih Puspita Febrinasari</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-76977573'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-76977573').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_76977573 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76977573"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76977573, container: ".js-paper-rank-work_76977573", }); });</script></li><li class="js-percentile-work_76977573 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 76977573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_76977573"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_76977573 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="76977573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 76977573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=76977573]").text(description); $(".js-view-count-work_76977573").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_76977573").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="76977573"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3286" rel="nofollow" href="https://www.academia.edu/Documents/in/Patient_Safety">Patient Safety</a>, <script data-card-contents-for-ri="3286" type="text/json">{"id":3286,"name":"Patient Safety","url":"https://www.academia.edu/Documents/in/Patient_Safety?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16288" rel="nofollow" href="https://www.academia.edu/Documents/in/Public_Health">Public Health</a>, <script data-card-contents-for-ri="16288" type="text/json">{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24735" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiovascular_disease">Cardiovascular disease</a><script data-card-contents-for-ri="24735" type="text/json">{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=76977573]'), work: {"id":76977573,"title":"COST-EFFECTIVENESS OF SACUBITRIL–VALSARTAN COMPARED TO ANGIOTENSIN-CONVERTING ENZYME INHIBITORS IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION","created_at":"2022-04-19T10:19:19.811-07:00","url":"https://www.academia.edu/76977573/COST_EFFECTIVENESS_OF_SACUBITRIL_VALSARTAN_COMPARED_TO_ANGIOTENSIN_CONVERTING_ENZYME_INHIBITORS_IN_PATIENTS_WITH_HEART_FAILURE_WITH_REDUCED_EJECTION_FRACTION?f_ri=49633","dom_id":"work_76977573","summary":"Objectives: The goal of this study was to compare cost-effectiveness of sacubitril/valsartan with angiotensin-converting enzyme (ACE) inhibitors for treating chronic heart failure patients with reduced ejection fraction (HFrEF) from the published articles and explore the methodology applied in the studies.\nMethods: Systematic research was conducted in February 2021 using PubMed, Cochrane, and EBSCO. A combination of MeSH terms of ‘cost-effectiveness analysis’, ‘heart failure with reduced ejection fraction’, ‘sacubitril valsartan’ and ‘angiotensin converting enzyme inhibitor’ was employed. The review selected for articles published in the last five years in English. \nResults: A total of 15 studies were included in this review. We found that the studies had been conducted in 12 different countries. The United States had the greatest number of publications (5), followed by the Netherlands (2). The study method most used was the Markov decision model (73%). Almost all studies produced ICERs and QALYs that were numerically high.\nConclusions: The use of sacubitril/valsartan associates with longer life expectancy and incremental cost-effectiveness ratio than angiotensin-converting enzyme inhibitors.\n","downloadable_attachments":[{"id":84519138,"asset_id":76977573,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":98064718,"first_name":"Stefanus Erdana","last_name":"Putra","domain_name":"uns-id","page_name":"StefanusErdanaPutra","display_name":"Stefanus Erdana Putra","profile_url":"https://uns-id.academia.edu/StefanusErdanaPutra?f_ri=49633","photo":"https://0.academia-photos.com/98064718/21848360/35507648/s65_stefanus_erdana.putra.jpg"},{"id":222098217,"first_name":"Ratih","last_name":"Puspita Febrinasari","domain_name":"independent","page_name":"RatihPuspitaFebrinasari","display_name":"Ratih Puspita Febrinasari","profile_url":"https://independent.academia.edu/RatihPuspitaFebrinasari?f_ri=49633","photo":"https://0.academia-photos.com/222098217/79777096/68346852/s65_ratih.puspita_febrinasari.jpeg"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":3286,"name":"Patient Safety","url":"https://www.academia.edu/Documents/in/Patient_Safety?f_ri=49633","nofollow":true},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=49633","nofollow":true},{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease?f_ri=49633","nofollow":true},{"id":32355,"name":"Cost Management","url":"https://www.academia.edu/Documents/in/Cost_Management?f_ri=49633"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":705104,"name":"Valsartan","url":"https://www.academia.edu/Documents/in/Valsartan?f_ri=49633"},{"id":719604,"name":"Angiotensin Converting Enzyme","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme?f_ri=49633"},{"id":3767164,"name":"Sacubitril","url":"https://www.academia.edu/Documents/in/Sacubitril?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73504074" data-work_id="73504074" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73504074/Intensive_vs_Standard_Blood_Pressure_Control_and_Cardiovascular_Disease_Outcomes_in_Adults_Aged_75_Years_A_Randomized_Clinical_Trial">Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. To evaluate the effects of intensive (&lt;120 mm Hg) compared with standard (&lt;140 mm Hg) SBP targets in persons... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73504074" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. To evaluate the effects of intensive (&lt;120 mm Hg) compared with standard (&lt;140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes. A multicenter, randomized clinical trial of patients aged 75 years or older who participated in the Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010, and follow-up ended on August 20, 2015. Participants were randomized to an SBP target of less than 120 mm Hg (intensive treatment group, n = 1317) or an SBP target of less than 140 mm Hg (standard treatment group, n = 1319). The primary cardiovascular disease outcome was a composite of nonfatal myocardial infarction, acute coronary syndrome not resulting in a myocardial infarction, nonfatal stroke, nonfatal acute decompensated heart failure, and death from cardiovascular causes. All-cause mortality w...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73504074" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dfd21720445687c19af1b2385448d2cd" rel="nofollow" data-download="{"attachment_id":82001668,"asset_id":73504074,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82001668/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51581174" href="https://independent.academia.edu/ChristianneRoumie">Christianne Roumie</a><script data-card-contents-for-user="51581174" type="text/json">{"id":51581174,"first_name":"Christianne","last_name":"Roumie","domain_name":"independent","page_name":"ChristianneRoumie","display_name":"Christianne Roumie","profile_url":"https://independent.academia.edu/ChristianneRoumie?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73504074 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73504074"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73504074, container: ".js-paper-rank-work_73504074", }); 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To evaluate the effects of intensive (\u0026lt;120 mm Hg) compared with standard (\u0026lt;140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes. A multicenter, randomized clinical trial of patients aged 75 years or older who participated in the Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010, and follow-up ended on August 20, 2015. Participants were randomized to an SBP target of less than 120 mm Hg (intensive treatment group, n = 1317) or an SBP target of less than 140 mm Hg (standard treatment group, n = 1319). The primary cardiovascular disease outcome was a composite of nonfatal myocardial infarction, acute coronary syndrome not resulting in a myocardial infarction, nonfatal stroke, nonfatal acute decompensated heart failure, and death from cardiovascular causes. All-cause mortality w...","downloadable_attachments":[{"id":82001668,"asset_id":73504074,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51581174,"first_name":"Christianne","last_name":"Roumie","domain_name":"independent","page_name":"ChristianneRoumie","display_name":"Christianne Roumie","profile_url":"https://independent.academia.edu/ChristianneRoumie?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=49633","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=49633","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633","nofollow":true},{"id":300876,"name":"Acute Coronary Syndrome","url":"https://www.academia.edu/Documents/in/Acute_Coronary_Syndrome?f_ri=49633"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction?f_ri=49633"},{"id":1504413,"name":"JAMA","url":"https://www.academia.edu/Documents/in/JAMA?f_ri=49633"},{"id":3197604,"name":"Cause of death","url":"https://www.academia.edu/Documents/in/Cause_of_death?f_ri=49633"},{"id":3489153,"name":"Antihypertensive agents","url":"https://www.academia.edu/Documents/in/Antihypertensive_agents?f_ri=49633"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64346884" data-work_id="64346884" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64346884/Long_term_effects_of_a_once_a_day_versus_twice_a_day_regimen_of_enalapril_for_congestive_heart_failure">Long-term effects of a once-a-day versus twice-a-day regimen of enalapril for congestive heart failure</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64346884" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b626a0f665930b7eb3e0a2b726b73647" rel="nofollow" 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type="text/json">{"id":71284,"name":"Enalapril","url":"https://www.academia.edu/Documents/in/Enalapril?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" rel="nofollow" href="https://www.academia.edu/Documents/in/Aged">Aged</a>, <script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="413195" rel="nofollow" href="https://www.academia.edu/Documents/in/Time_Factors">Time Factors</a><script data-card-contents-for-ri="413195" type="text/json">{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64346884]'), work: {"id":64346884,"title":"Long-term effects of a once-a-day versus twice-a-day regimen of enalapril for congestive heart failure","created_at":"2021-12-15T10:54:51.375-08:00","url":"https://www.academia.edu/64346884/Long_term_effects_of_a_once_a_day_versus_twice_a_day_regimen_of_enalapril_for_congestive_heart_failure?f_ri=49633","dom_id":"work_64346884","summary":null,"downloadable_attachments":[{"id":76424081,"asset_id":64346884,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":145069568,"first_name":"Gidudu","last_name":"Francis","domain_name":"icpau","page_name":"GiduduFrancis","display_name":"Gidudu Francis","profile_url":"https://icpau.academia.edu/GiduduFrancis?f_ri=49633","photo":"https://0.academia-photos.com/145069568/151043809/140628879/s65_gidudu.francis.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":71284,"name":"Enalapril","url":"https://www.academia.edu/Documents/in/Enalapril?f_ri=49633","nofollow":true},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633","nofollow":true},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=49633","nofollow":true},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test?f_ri=49633"},{"id":1592853,"name":"Drug Tolerance","url":"https://www.academia.edu/Documents/in/Drug_Tolerance?f_ri=49633"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation?f_ri=49633"},{"id":2463778,"name":"Clinical Trials as Topic","url":"https://www.academia.edu/Documents/in/Clinical_Trials_as_Topic?f_ri=49633"},{"id":2471457,"name":"Multicenter Studies as Topic","url":"https://www.academia.edu/Documents/in/Multicenter_Studies_as_Topic?f_ri=49633"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59698422" data-work_id="59698422" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59698422/2013_ACCF_AHA_Guideline_for_the_Management_of_Heart_Failure_A_Report_of_the_American_College_of_Cardiology_Foundation_American_Heart_Association_Task_Force_on_Practice_Guidelines">2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Additionally, the committee reviewed documents related to the subject matter previously published by the ACCF and AHA. References selected and published in this document are representative and not all-inclusive. To provide clinicians with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59698422" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Additionally, the committee reviewed documents related to the subject matter previously published by the ACCF and AHA. References selected and published in this document are representative and not all-inclusive. To provide clinicians with a representative evidence base, whenever deemed appropriate or when published, the absolute risk difference and number needed to treat or harm are provided in the guideline (within tables), along with confidence intervals and data related to the relative treatment effects such as odds ratio, relative risk, hazard ratio, and incidence rate ratio.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59698422" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d128c9e8f20e29b4233144d211171e46" rel="nofollow" data-download="{"attachment_id":73486976,"asset_id":59698422,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73486976/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41101047" href="https://independent.academia.edu/EdwardKasper">Edward Kasper</a><script data-card-contents-for-user="41101047" type="text/json">{"id":41101047,"first_name":"Edward","last_name":"Kasper","domain_name":"independent","page_name":"EdwardKasper","display_name":"Edward Kasper","profile_url":"https://independent.academia.edu/EdwardKasper?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_59698422 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59698422"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59698422, container: ".js-paper-rank-work_59698422", }); 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$(".js-view-count[data-work-id=59698422]").text(description); $(".js-view-count-work_59698422").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_59698422").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="59698422"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3645" rel="nofollow" href="https://www.academia.edu/Documents/in/Evidence_Based_Medicine">Evidence Based Medicine</a>, <script data-card-contents-for-ri="3645" type="text/json">{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3709" rel="nofollow" href="https://www.academia.edu/Documents/in/Evidence_Based_Practice">Evidence Based Practice</a>, <script data-card-contents-for-ri="3709" type="text/json">{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59698422]'), work: {"id":59698422,"title":"2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines","created_at":"2021-10-23T13:27:10.758-07:00","url":"https://www.academia.edu/59698422/2013_ACCF_AHA_Guideline_for_the_Management_of_Heart_Failure_A_Report_of_the_American_College_of_Cardiology_Foundation_American_Heart_Association_Task_Force_on_Practice_Guidelines?f_ri=49633","dom_id":"work_59698422","summary":"Additionally, the committee reviewed documents related to the subject matter previously published by the ACCF and AHA. References selected and published in this document are representative and not all-inclusive. To provide clinicians with a representative evidence base, whenever deemed appropriate or when published, the absolute risk difference and number needed to treat or harm are provided in the guideline (within tables), along with confidence intervals and data related to the relative treatment effects such as odds ratio, relative risk, hazard ratio, and incidence rate ratio.","downloadable_attachments":[{"id":73486976,"asset_id":59698422,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41101047,"first_name":"Edward","last_name":"Kasper","domain_name":"independent","page_name":"EdwardKasper","display_name":"Edward Kasper","profile_url":"https://independent.academia.edu/EdwardKasper?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":3645,"name":"Evidence Based Medicine","url":"https://www.academia.edu/Documents/in/Evidence_Based_Medicine?f_ri=49633","nofollow":true},{"id":3709,"name":"Evidence Based Practice","url":"https://www.academia.edu/Documents/in/Evidence_Based_Practice?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=49633"},{"id":138569,"name":"Advisory Committees","url":"https://www.academia.edu/Documents/in/Advisory_Committees?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633"},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation?f_ri=49633"},{"id":690114,"name":"American Heart Association","url":"https://www.academia.edu/Documents/in/American_Heart_Association?f_ri=49633"},{"id":906958,"name":"Disease Management","url":"https://www.academia.edu/Documents/in/Disease_Management?f_ri=49633"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49724589" data-work_id="49724589" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49724589/Abnormal_pulmonary_function_specifically_related_to_congestive_heart_failure_Comparison_of_patients_before_and_after_cardiac_transplantation">Abnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A variety of abnormalities in pulmonary function have been attributed to, or are believed to be, exacerbated by congestive heart failure. Separating out specific contributions from cardiac versus pnimonary disease is difficult. In order... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49724589" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A variety of abnormalities in pulmonary function have been attributed to, or are believed to be, exacerbated by congestive heart failure. Separating out specific contributions from cardiac versus pnimonary disease is difficult. In order to investigate the impact of cardiac disease on pulmonary function, we performed spirometry on patients immediately before and after cardiac transplantation. PATIENTS AND METHODS: Seventeen patients (13 men, 4 women) with a mean age of 44 years (range: 20 to 62 years) were studied before and 15 4-10 (mean 4-SD) months after cardiac transplantation. Eleven patients had a significant smoking history. RESULTS: In comparing pre-and post-transplant spirometric results, forced vital capacity (FVC) and forced expiratory volume in 1 second (FEVI) increased substantially after transplant (3.34 4-0.96 L versus 3.89 4-1.00 L, p-0.0054, and 2.63 4-0.80 L versus 2.95 4-0.83 L, p = 0.042, respectively). FEV1/ FVC was not significantly different between study states in the entire group (0.78 4-0.10 versus 0.76 4-0.10, p = NS), nor was it different in those patients with and without a smoking history (0.76 4-0.11</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49724589" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6d5b8f2e90469bc5abf89304981372b5" rel="nofollow" data-download="{"attachment_id":67987010,"asset_id":49724589,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67987010/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42413115" href="https://independent.academia.edu/ThomasStibolt">Thomas Stibolt</a><script data-card-contents-for-user="42413115" type="text/json">{"id":42413115,"first_name":"Thomas","last_name":"Stibolt","domain_name":"independent","page_name":"ThomasStibolt","display_name":"Thomas Stibolt","profile_url":"https://independent.academia.edu/ThomasStibolt?f_ri=49633","photo":"https://0.academia-photos.com/42413115/19608388/19495082/s65_thomas.stibolt.jpeg"}</script></span></span></li><li class="js-paper-rank-work_49724589 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49724589"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49724589, container: ".js-paper-rank-work_49724589", }); 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$(".js-view-count[data-work-id=49724589]").text(description); $(".js-view-count-work_49724589").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49724589").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="49724589"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74347" rel="nofollow" href="https://www.academia.edu/Documents/in/Hemodynamics">Hemodynamics</a>, <script data-card-contents-for-ri="74347" type="text/json">{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="75318" rel="nofollow" href="https://www.academia.edu/Documents/in/Smoking">Smoking</a>, <script data-card-contents-for-ri="75318" type="text/json">{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="88114" rel="nofollow" href="https://www.academia.edu/Documents/in/Congestive_Heart_Failure">Congestive Heart Failure</a><script data-card-contents-for-ri="88114" type="text/json">{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49724589]'), work: {"id":49724589,"title":"Abnormal pulmonary function specifically related to congestive heart failure: Comparison of patients before and after cardiac transplantation","created_at":"2021-07-10T22:14:26.188-07:00","url":"https://www.academia.edu/49724589/Abnormal_pulmonary_function_specifically_related_to_congestive_heart_failure_Comparison_of_patients_before_and_after_cardiac_transplantation?f_ri=49633","dom_id":"work_49724589","summary":"A variety of abnormalities in pulmonary function have been attributed to, or are believed to be, exacerbated by congestive heart failure. Separating out specific contributions from cardiac versus pnimonary disease is difficult. In order to investigate the impact of cardiac disease on pulmonary function, we performed spirometry on patients immediately before and after cardiac transplantation. PATIENTS AND METHODS: Seventeen patients (13 men, 4 women) with a mean age of 44 years (range: 20 to 62 years) were studied before and 15 4-10 (mean 4-SD) months after cardiac transplantation. Eleven patients had a significant smoking history. RESULTS: In comparing pre-and post-transplant spirometric results, forced vital capacity (FVC) and forced expiratory volume in 1 second (FEVI) increased substantially after transplant (3.34 4-0.96 L versus 3.89 4-1.00 L, p-0.0054, and 2.63 4-0.80 L versus 2.95 4-0.83 L, p = 0.042, respectively). FEV1/ FVC was not significantly different between study states in the entire group (0.78 4-0.10 versus 0.76 4-0.10, p = NS), nor was it different in those patients with and without a smoking history (0.76 4-0.11","downloadable_attachments":[{"id":67987010,"asset_id":49724589,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42413115,"first_name":"Thomas","last_name":"Stibolt","domain_name":"independent","page_name":"ThomasStibolt","display_name":"Thomas Stibolt","profile_url":"https://independent.academia.edu/ThomasStibolt?f_ri=49633","photo":"https://0.academia-photos.com/42413115/19608388/19495082/s65_thomas.stibolt.jpeg"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=49633","nofollow":true},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=49633","nofollow":true},{"id":88114,"name":"Congestive Heart Failure","url":"https://www.academia.edu/Documents/in/Congestive_Heart_Failure?f_ri=49633","nofollow":true},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=49633"},{"id":378984,"name":"Spirometry","url":"https://www.academia.edu/Documents/in/Spirometry?f_ri=49633"},{"id":677189,"name":"Pulmonary Function","url":"https://www.academia.edu/Documents/in/Pulmonary_Function?f_ri=49633"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=49633"},{"id":1793399,"name":"Cardiac Transplantation","url":"https://www.academia.edu/Documents/in/Cardiac_Transplantation?f_ri=49633"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests?f_ri=49633"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_36739097" data-work_id="36739097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/36739097/Bidirectional_shunt_in_uncomplicated_atrial_septal_defect">Bidirectional shunt in uncomplicated atrial septal defect</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_36739097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right to left shunt was found: left atrial oxygen stepdown was >0 7 vol%, mean right to left shunt 0-67 1/min/m2 (range 0.361-0), and arterial oxygen saturation between 84% and 90.5%. The patients in group 1 did not show any differences from those with left to right shunts alone (group 2) as regards sex, cardiac rhythm, heart rate, "a" wave and mean right atrial pressure, end diastolic right ventricular pressure, morphology of diastolic right ventricular pressure curves, pulmonary to systemic vascular resistance ratio, size of the defect, and coexistence of anomalous pulmonary venous drainage. Patients with coexisting right to left shunts were, however, significantly older and had smaller left to right shunts.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/36739097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c0f67b88f6f6304471240333afd36642" rel="nofollow" data-download="{"attachment_id":56682269,"asset_id":36739097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/56682269/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64787511" href="https://independent.academia.edu/JuanAngel63">Juan Angel</a><script data-card-contents-for-user="64787511" type="text/json">{"id":64787511,"first_name":"Juan","last_name":"Angel","domain_name":"independent","page_name":"JuanAngel63","display_name":"Juan Angel","profile_url":"https://independent.academia.edu/JuanAngel63?f_ri=49633","photo":"https://0.academia-photos.com/64787511/34318770/30213250/s65_juan.angel.jpg"}</script></span></span></li><li class="js-paper-rank-work_36739097 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="36739097"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 36739097, container: ".js-paper-rank-work_36739097", }); 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$(".js-view-count[data-work-id=36739097]").text(description); $(".js-view-count-work_36739097").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_36739097").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="36739097"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31958" rel="nofollow" href="https://www.academia.edu/Documents/in/Pulmonary_Hypertension">Pulmonary Hypertension</a>, <script data-card-contents-for-ri="31958" type="text/json">{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=36739097]'), work: {"id":36739097,"title":"Bidirectional shunt in uncomplicated atrial septal defect","created_at":"2018-05-29T04:56:33.224-07:00","url":"https://www.academia.edu/36739097/Bidirectional_shunt_in_uncomplicated_atrial_septal_defect?f_ri=49633","dom_id":"work_36739097","summary":"The presence of right to left shunts at atrial level in 40 patients with an uncomplicated atrial septal defect was determined by measuring the pulmonary vein to systemic artery oxygen stepdown. In six patients (group 1) a sizeable right to left shunt was found: left atrial oxygen stepdown was \u003e0 7 vol%, mean right to left shunt 0-67 1/min/m2 (range 0.361-0), and arterial oxygen saturation between 84% and 90.5%. The patients in group 1 did not show any differences from those with left to right shunts alone (group 2) as regards sex, cardiac rhythm, heart rate, \"a\" wave and mean right atrial pressure, end diastolic right ventricular pressure, morphology of diastolic right ventricular pressure curves, pulmonary to systemic vascular resistance ratio, size of the defect, and coexistence of anomalous pulmonary venous drainage. Patients with coexisting right to left shunts were, however, significantly older and had smaller left to right shunts.","downloadable_attachments":[{"id":56682269,"asset_id":36739097,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64787511,"first_name":"Juan","last_name":"Angel","domain_name":"independent","page_name":"JuanAngel63","display_name":"Juan Angel","profile_url":"https://independent.academia.edu/JuanAngel63?f_ri=49633","photo":"https://0.academia-photos.com/64787511/34318770/30213250/s65_juan.angel.jpg"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true},{"id":31958,"name":"Pulmonary Hypertension","url":"https://www.academia.edu/Documents/in/Pulmonary_Hypertension?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=49633","nofollow":true},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=49633"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate?f_ri=49633"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":291048,"name":"Cardiac Catheterization","url":"https://www.academia.edu/Documents/in/Cardiac_Catheterization?f_ri=49633"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=49633"},{"id":487159,"name":"Group","url":"https://www.academia.edu/Documents/in/Group?f_ri=49633"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=49633"},{"id":1325909,"name":"Atrial Septal Defect","url":"https://www.academia.edu/Documents/in/Atrial_Septal_Defect?f_ri=49633"},{"id":1558342,"name":"Oxygen saturation","url":"https://www.academia.edu/Documents/in/Oxygen_saturation?f_ri=49633"},{"id":1969879,"name":"Vascular Resistance","url":"https://www.academia.edu/Documents/in/Vascular_Resistance?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30856569" data-work_id="30856569" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30856569/Predicting_death_due_to_progressive_heart_failure_in_patients_with_mild_to_moderate_chronic_heart_failure">Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to explore the value of noninvasive predictors of death/mode of death in ambulant outpatients with chronic heart failure (HF). BACKGROUND Mortality in chronic HF remains high, with a significant number of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30856569" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to explore the value of noninvasive predictors of death/mode of death in ambulant outpatients with chronic heart failure (HF). BACKGROUND Mortality in chronic HF remains high, with a significant number of patients dying of progressive disease. Identification of these patients is important.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30856569" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="919613e272206960bd5aae71bde784dd" rel="nofollow" data-download="{"attachment_id":51283191,"asset_id":30856569,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51283191/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="58727913" href="https://independent.academia.edu/JamesNolan15">James Nolan</a><script data-card-contents-for-user="58727913" type="text/json">{"id":58727913,"first_name":"James","last_name":"Nolan","domain_name":"independent","page_name":"JamesNolan15","display_name":"James Nolan","profile_url":"https://independent.academia.edu/JamesNolan15?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30856569 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30856569"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30856569, container: ".js-paper-rank-work_30856569", }); });</script></li><li class="js-percentile-work_30856569 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30856569; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_30856569"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_30856569 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="30856569"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30856569; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30856569]").text(description); $(".js-view-count-work_30856569").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30856569").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30856569"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="30372" rel="nofollow" href="https://www.academia.edu/Documents/in/Low_Frequency">Low Frequency</a>, <script data-card-contents-for-ri="30372" type="text/json">{"id":30372,"name":"Low Frequency","url":"https://www.academia.edu/Documents/in/Low_Frequency?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41482" rel="nofollow" href="https://www.academia.edu/Documents/in/Multivariate_Analysis">Multivariate Analysis</a>, <script data-card-contents-for-ri="41482" type="text/json">{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30856569]'), work: {"id":30856569,"title":"Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure","created_at":"2017-01-10T06:23:55.461-08:00","url":"https://www.academia.edu/30856569/Predicting_death_due_to_progressive_heart_failure_in_patients_with_mild_to_moderate_chronic_heart_failure?f_ri=49633","dom_id":"work_30856569","summary":"The aim of this study was to explore the value of noninvasive predictors of death/mode of death in ambulant outpatients with chronic heart failure (HF). BACKGROUND Mortality in chronic HF remains high, with a significant number of patients dying of progressive disease. Identification of these patients is important.","downloadable_attachments":[{"id":51283191,"asset_id":30856569,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":58727913,"first_name":"James","last_name":"Nolan","domain_name":"independent","page_name":"JamesNolan15","display_name":"James Nolan","profile_url":"https://independent.academia.edu/JamesNolan15?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true},{"id":30372,"name":"Low Frequency","url":"https://www.academia.edu/Documents/in/Low_Frequency?f_ri=49633","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=49633"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=49633"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate?f_ri=49633"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":291274,"name":"Great Britain","url":"https://www.academia.edu/Documents/in/Great_Britain?f_ri=49633"},{"id":363788,"name":"Receiving Operating Characteristic","url":"https://www.academia.edu/Documents/in/Receiving_Operating_Characteristic?f_ri=49633"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633"},{"id":411266,"name":"Chronic Heart Failure","url":"https://www.academia.edu/Documents/in/Chronic_Heart_Failure?f_ri=49633"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=49633"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=49633"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=49633"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=49633"},{"id":2366663,"name":"Glomerular Filtration Rate","url":"https://www.academia.edu/Documents/in/Glomerular_Filtration_Rate?f_ri=49633"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_3615452" data-work_id="3615452" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3615452/Long_Term_Prospective_Randomized_Controlled_Study_Using_Repetitive_Education_at_Six_Month_Intervals_and_Monitoring_for_Adherence_in_Heart_Failure_Outpatients_The_REMADHE_Trial">Long-Term Prospective, Randomized, Controlled Study Using Repetitive Education at Six-Month Intervals and Monitoring for Adherence in Heart Failure Outpatients: The REMADHE Trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Background The effectiveness of heart failure(HF) disease management programs(DMP) in patients under cardiologists´care over long-term follow-up is not established.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3615452" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="282d8deaf7cb88acb95ece23c63199b2" rel="nofollow" data-download="{"attachment_id":50198219,"asset_id":3615452,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50198219/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3928039" href="https://uerj.academia.edu/LuizGuilhermeIssa">Luiz Guilherme Issa</a><script data-card-contents-for-user="3928039" type="text/json">{"id":3928039,"first_name":"Luiz Guilherme","last_name":"Issa","domain_name":"uerj","page_name":"LuizGuilhermeIssa","display_name":"Luiz Guilherme Issa","profile_url":"https://uerj.academia.edu/LuizGuilhermeIssa?f_ri=49633","photo":"https://0.academia-photos.com/3928039/1465108/1789879/s65_luiz_guilherme.issa.jpg"}</script></span></span></li><li class="js-paper-rank-work_3615452 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3615452"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3615452, container: ".js-paper-rank-work_3615452", }); });</script></li><li class="js-percentile-work_3615452 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3615452; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_3615452"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); 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u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9821" rel="nofollow" href="https://www.academia.edu/Documents/in/Brazil">Brazil</a>, <script data-card-contents-for-ri="9821" type="text/json">{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3615452]'), work: {"id":3615452,"title":"Long-Term Prospective, Randomized, Controlled Study Using Repetitive Education at Six-Month Intervals and Monitoring for Adherence in Heart Failure Outpatients: The REMADHE Trial","created_at":"2013-05-27T13:31:01.448-07:00","url":"https://www.academia.edu/3615452/Long_Term_Prospective_Randomized_Controlled_Study_Using_Repetitive_Education_at_Six_Month_Intervals_and_Monitoring_for_Adherence_in_Heart_Failure_Outpatients_The_REMADHE_Trial?f_ri=49633","dom_id":"work_3615452","summary":"Background The effectiveness of heart failure(HF) disease management programs(DMP) in patients under cardiologists´care over long-term follow-up is not established.","downloadable_attachments":[{"id":50198219,"asset_id":3615452,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3928039,"first_name":"Luiz Guilherme","last_name":"Issa","domain_name":"uerj","page_name":"LuizGuilhermeIssa","display_name":"Luiz Guilherme Issa","profile_url":"https://uerj.academia.edu/LuizGuilhermeIssa?f_ri=49633","photo":"https://0.academia-photos.com/3928039/1465108/1789879/s65_luiz_guilherme.issa.jpg"}],"research_interests":[{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=49633","nofollow":true},{"id":9821,"name":"Brazil","url":"https://www.academia.edu/Documents/in/Brazil?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=49633","nofollow":true},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633"},{"id":135005,"name":"Patient Compliance","url":"https://www.academia.edu/Documents/in/Patient_Compliance?f_ri=49633"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":187758,"name":"Case Management","url":"https://www.academia.edu/Documents/in/Case_Management?f_ri=49633"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=49633"},{"id":378991,"name":"Outpatients","url":"https://www.academia.edu/Documents/in/Outpatients?f_ri=49633"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=49633"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=49633"},{"id":584597,"name":"Controlled Clinical Trial","url":"https://www.academia.edu/Documents/in/Controlled_Clinical_Trial?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5768262" data-work_id="5768262" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5768262/MRI_to_X_ray_fluoroscopy_overlay_for_guidance_of_cardiac_resynchronization_therapy_procedures">MRI to X-ray fluoroscopy overlay for guidance of cardiac resynchronization therapy procedures</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cardiac resynchronization therapy (CRT) can be an effective procedure for patients with heart failure but 30% of patients do not respond. This may be partially caused by the sub-optimal placement of the left ventricular lead. We... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5768262" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cardiac resynchronization therapy (CRT) can be an effective procedure for patients with heart failure but 30% of patients do not respond. This may be partially caused by the sub-optimal placement of the left ventricular lead. We demonstrate how pre-procedural cardiac MR images can be used to assist CRT by integration of anatomical and functional information with live X-ray images. We evaluated our approach in 7 patients. Each patient underwent pre-CRT MRI scan using MultiHance contrast. This included whole heart imaging sequence; 3D tagged and cine imaging for function; and late enhancement imaging for scar. The MRI data were processed to yield a detailed anatomical model. Whole heart segmentation was achieved automatically using the Philips EP Planner and the coronary venous anatomy was manually segmented by a clinical expert. Functional information was derived using the Tomtec 4D LV-Analysis. The left ventricle was segmented into the standard 16 segment AHA model and the functional information could be added to this. If scar was present, this was segmented by an expert and added to the model. The implant was carried out using a Philips Allura X-ray system and the detailed cardiac model was registered to the X-ray fluoroscopy using multiple views of a catheter looped in the right atrium. There was complete freedom of movement of the X-ray system and respiratory motion compensation was achieved by tracking the diaphragm. The software framework was a specially modified version of the Philips EP Navigator. We validated the registration using balloon occlusion coronary veno-grams. The mean 2D target registration error for 7 patients was 1.3±0.68 mm. Furthermore, left lead deployment was successful in all patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5768262" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ecc322f525fa3b1aecfd1b1b9f4322df" rel="nofollow" data-download="{"attachment_id":49146077,"asset_id":5768262,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49146077/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8416645" href="https://independent.academia.edu/PhaniChinchapatnam">Phani Chinchapatnam</a><script data-card-contents-for-user="8416645" type="text/json">{"id":8416645,"first_name":"Phani","last_name":"Chinchapatnam","domain_name":"independent","page_name":"PhaniChinchapatnam","display_name":"Phani Chinchapatnam","profile_url":"https://independent.academia.edu/PhaniChinchapatnam?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_5768262 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5768262"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5768262, container: ".js-paper-rank-work_5768262", }); 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This may be partially caused by the sub-optimal placement of the left ventricular lead. We demonstrate how pre-procedural cardiac MR images can be used to assist CRT by integration of anatomical and functional information with live X-ray images. We evaluated our approach in 7 patients. Each patient underwent pre-CRT MRI scan using MultiHance contrast. This included whole heart imaging sequence; 3D tagged and cine imaging for function; and late enhancement imaging for scar. The MRI data were processed to yield a detailed anatomical model. Whole heart segmentation was achieved automatically using the Philips EP Planner and the coronary venous anatomy was manually segmented by a clinical expert. Functional information was derived using the Tomtec 4D LV-Analysis. The left ventricle was segmented into the standard 16 segment AHA model and the functional information could be added to this. If scar was present, this was segmented by an expert and added to the model. The implant was carried out using a Philips Allura X-ray system and the detailed cardiac model was registered to the X-ray fluoroscopy using multiple views of a catheter looped in the right atrium. There was complete freedom of movement of the X-ray system and respiratory motion compensation was achieved by tracking the diaphragm. The software framework was a specially modified version of the Philips EP Navigator. We validated the registration using balloon occlusion coronary veno-grams. The mean 2D target registration error for 7 patients was 1.3±0.68 mm. Furthermore, left lead deployment was successful in all patients.","downloadable_attachments":[{"id":49146077,"asset_id":5768262,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":8416645,"first_name":"Phani","last_name":"Chinchapatnam","domain_name":"independent","page_name":"PhaniChinchapatnam","display_name":"Phani Chinchapatnam","profile_url":"https://independent.academia.edu/PhaniChinchapatnam?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":10654,"name":"X-ray imaging","url":"https://www.academia.edu/Documents/in/X-ray_imaging?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":56001,"name":"X Rays","url":"https://www.academia.edu/Documents/in/X_Rays?f_ri=49633","nofollow":true},{"id":88113,"name":"Left Ventricular Assist Device","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Assist_Device?f_ri=49633"},{"id":151108,"name":"Respiratory Motion","url":"https://www.academia.edu/Documents/in/Respiratory_Motion?f_ri=49633"},{"id":243832,"name":"Software Framework","url":"https://www.academia.edu/Documents/in/Software_Framework?f_ri=49633"},{"id":919179,"name":"Cardiac-Resynchronization-Therapy-Devices-Market","url":"https://www.academia.edu/Documents/in/Cardiac-Resynchronization-Therapy-Devices-Market?f_ri=49633"},{"id":1015743,"name":"Image Sequence","url":"https://www.academia.edu/Documents/in/Image_Sequence?f_ri=49633"},{"id":1122411,"name":"Mr Imaging","url":"https://www.academia.edu/Documents/in/Mr_Imaging?f_ri=49633"},{"id":1254076,"name":"Right Atrium","url":"https://www.academia.edu/Documents/in/Right_Atrium?f_ri=49633"},{"id":1269419,"name":"Multiple Views","url":"https://www.academia.edu/Documents/in/Multiple_Views?f_ri=49633"},{"id":1572218,"name":"Left Ventricle","url":"https://www.academia.edu/Documents/in/Left_Ventricle?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9360358" data-work_id="9360358" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9360358/Cardiac_Specific_Overexpression_of_GLUT1_Prevents_the_Development_of_Heart_Failure_Attributable_to_Pressure_Overload_in_Mice">Cardiac-Specific Overexpression of GLUT1 Prevents the Development of Heart Failure Attributable to Pressure Overload in Mice</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" 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itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12594218/A_new_use_for_B_type_natriuretic_peptide_to_detect_myocardial_ischaemia_in_non_heart_failure_patients">A new use for B-type natriuretic peptide: to detect myocardial ischaemia in non-heart failure patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">-type natriuretic peptide (BNP) is a natriuretic peptide released primarily by ventricular myocytes in response to various physiological and pathological stimuli. In addition to its established diagnostic role in patients with heart... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12594218" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">-type natriuretic peptide (BNP) is a natriuretic peptide released primarily by ventricular myocytes in response to various physiological and pathological stimuli. In addition to its established diagnostic role in patients with heart failure, a growing body of evidence suggests that raised levels of BNP in the absence of heart failure can indicate myocardial ischaemia. This appears to be the case in patients with symptomatic, and even asymptomatic coronary artery disease (CAD). In this review, we discuss the current evidence supporting the role of BNP as a simple marker of cardiac ischaemia and CAD. We also propose some therapeutic interventions that may be useful when BNP detects silent myocardial ischaemia. Br J Diabetes Vasc Dis 2010;10:78-82</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12594218" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3a2411141a37b3c9580d145fde57b129" rel="nofollow" data-download="{"attachment_id":46062622,"asset_id":12594218,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46062622/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31536066" href="https://independent.academia.edu/JacobGeorge21">Jacob George</a><script data-card-contents-for-user="31536066" type="text/json">{"id":31536066,"first_name":"Jacob","last_name":"George","domain_name":"independent","page_name":"JacobGeorge21","display_name":"Jacob George","profile_url":"https://independent.academia.edu/JacobGeorge21?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12594218 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12594218"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12594218, container: ".js-paper-rank-work_12594218", }); 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In addition to its established diagnostic role in patients with heart failure, a growing body of evidence suggests that raised levels of BNP in the absence of heart failure can indicate myocardial ischaemia. This appears to be the case in patients with symptomatic, and even asymptomatic coronary artery disease (CAD). In this review, we discuss the current evidence supporting the role of BNP as a simple marker of cardiac ischaemia and CAD. We also propose some therapeutic interventions that may be useful when BNP detects silent myocardial ischaemia. Br J Diabetes Vasc Dis 2010;10:78-82","downloadable_attachments":[{"id":46062622,"asset_id":12594218,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31536066,"first_name":"Jacob","last_name":"George","domain_name":"independent","page_name":"JacobGeorge21","display_name":"Jacob George","profile_url":"https://independent.academia.edu/JacobGeorge21?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633","nofollow":true},{"id":789977,"name":"Coronary Artery Disease","url":"https://www.academia.edu/Documents/in/Coronary_Artery_Disease?f_ri=49633","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13485840" data-work_id="13485840" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13485840/Clinical_and_echocardiographic_characteristics_of_patients_with_mitral_anular_calcification">Clinical and echocardiographic characteristics of patients with mitral anular calcification</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Background-Cardiac papillary fibroelastoma (CPF) is a primary cardiac neoplasm that is increasingly detected by echocardiography. The clinical manifestations of this entity are not well described.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13485840" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="580e555bc9fba06974a637fa1dcca255" rel="nofollow" data-download="{"attachment_id":45285438,"asset_id":13485840,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45285438/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32697189" href="https://uwm.academia.edu/BijoyKhandheria">Bijoy Khandheria</a><script data-card-contents-for-user="32697189" type="text/json">{"id":32697189,"first_name":"Bijoy","last_name":"Khandheria","domain_name":"uwm","page_name":"BijoyKhandheria","display_name":"Bijoy Khandheria","profile_url":"https://uwm.academia.edu/BijoyKhandheria?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13485840 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13485840"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13485840, container: ".js-paper-rank-work_13485840", }); 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The clinical manifestations of this entity are not well described.","downloadable_attachments":[{"id":45285438,"asset_id":13485840,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32697189,"first_name":"Bijoy","last_name":"Khandheria","domain_name":"uwm","page_name":"BijoyKhandheria","display_name":"Bijoy Khandheria","profile_url":"https://uwm.academia.edu/BijoyKhandheria?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=49633","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=49633","nofollow":true},{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=49633","nofollow":true},{"id":39851,"name":"Cardiac Surgery","url":"https://www.academia.edu/Documents/in/Cardiac_Surgery?f_ri=49633","nofollow":true},{"id":46824,"name":"Echocardiography","url":"https://www.academia.edu/Documents/in/Echocardiography?f_ri=49633"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633"},{"id":62235,"name":"Tuberculosis","url":"https://www.academia.edu/Documents/in/Tuberculosis?f_ri=49633"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization?f_ri=49633"},{"id":227310,"name":"Blood Urea Nitrogen","url":"https://www.academia.edu/Documents/in/Blood_Urea_Nitrogen?f_ri=49633"},{"id":231933,"name":"Mitral Valve Repair","url":"https://www.academia.edu/Documents/in/Mitral_Valve_Repair?f_ri=49633"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":312834,"name":"Cardiovascular system","url":"https://www.academia.edu/Documents/in/Cardiovascular_system?f_ri=49633"},{"id":313752,"name":"Gold Standard","url":"https://www.academia.edu/Documents/in/Gold_Standard?f_ri=49633"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=49633"},{"id":375133,"name":"Calcinosis","url":"https://www.academia.edu/Documents/in/Calcinosis?f_ri=49633"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=49633"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=49633"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=49633"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=49633"},{"id":496063,"name":"Thrombosis","url":"https://www.academia.edu/Documents/in/Thrombosis?f_ri=49633"},{"id":515070,"name":"Circulation","url":"https://www.academia.edu/Documents/in/Circulation?f_ri=49633"},{"id":532928,"name":"Chest","url":"https://www.academia.edu/Documents/in/Chest?f_ri=49633"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=49633"},{"id":911627,"name":"Pulmonary Tuberculosis","url":"https://www.academia.edu/Documents/in/Pulmonary_Tuberculosis?f_ri=49633"},{"id":1311261,"name":"Hemoglobins","url":"https://www.academia.edu/Documents/in/Hemoglobins?f_ri=49633"},{"id":1312754,"name":"Prospective Study","url":"https://www.academia.edu/Documents/in/Prospective_Study?f_ri=49633"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=49633"},{"id":2207328,"name":"Heart Diseases","url":"https://www.academia.edu/Documents/in/Heart_Diseases?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13616055 coauthored" data-work_id="13616055" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13616055/The_impact_of_body_mass_index_on_clinical_outcomes_after_acute_myocardial_infarction">The impact of body mass index on clinical outcomes after acute myocardial infarction</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Several studies indicated that an elevated body mass index (BMI) is associated with a lower rate of mortality in patients with acute myocardial infarction (AMI). However, the existence of the obesity paradox in AMI patients... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13616055" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Several studies indicated that an elevated body mass index (BMI) is associated with a lower rate of mortality in patients with acute myocardial infarction (AMI). However, the existence of the obesity paradox in AMI patients remains controversial. Methods: We examined the association of BMI and clinical outcomes in 2157 patient with AMI (mean followup of 26 months). BMI was categorized into 9 groups (b 18.5, 18.5 to 20.9, 21.0 to 23.4, 23.5 to 24.9, 25.0 to 26.4, 26.5 to 27.9, 28.0 to 29.9, 30.0 to 34.9, and ≥ 35.0 kg/m 2 ). Cox regression was used to calculate hazard ratios (HR) for the various BMI categories, adjusting for the clinical variables, left ventricular ejection fraction, and hemoglobin level. Results: BMI had a U-shaped association with mortality. Relative to the lowest mortality group (BMI of 26.5 to 27.9 kg/m 2 ), the adjusted HRs for mortality were increased only in the lower (HR 2.3; 95% CI 1.3-4.2) and upper (HR 1.8; 95% 1.2-2.9) BMI categories. There was a significant interaction between BMI and anemia (P = 0.0003) such that the U-shaped relationship between BMI and mortality was present mainly in patients with anemia. Patients in the lower and upper BMI categories and concomitant anemia had a striking increase in mortality (adjusted HR 5.1, 95% CI 1.9-11.7 and 3.2, 95% CI 1.5-7.0, respectively). Conclusion: Both obesity and underweight are associated with increased mortality in patients with AMI. The risk of mortality is particularly high among underweight and obese patients with anemia.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13616055" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7d60d77ab34a63245c9122df041592ba" rel="nofollow" data-download="{"attachment_id":45151908,"asset_id":13616055,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45151908/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32813596" href="https://independent.academia.edu/ZaherAzzam">Zaher Azzam</a><script data-card-contents-for-user="32813596" type="text/json">{"id":32813596,"first_name":"Zaher","last_name":"Azzam","domain_name":"independent","page_name":"ZaherAzzam","display_name":"Zaher Azzam","profile_url":"https://independent.academia.edu/ZaherAzzam?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13616055">+1</span><div class="hidden js-additional-users-13616055"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://csregistry.academia.edu/DoronAronson">Doron Aronson</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-13616055'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-13616055').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_13616055 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13616055"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13616055, container: ".js-paper-rank-work_13616055", }); });</script></li><li class="js-percentile-work_13616055 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13616055; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13616055"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13616055 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13616055"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13616055; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13616055]").text(description); $(".js-view-count-work_13616055").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13616055").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13616055"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3851" rel="nofollow" href="https://www.academia.edu/Documents/in/Obesity">Obesity</a>, <script data-card-contents-for-ri="3851" type="text/json">{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a>, <script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="136346" rel="nofollow" href="https://www.academia.edu/Documents/in/Anemia">Anemia</a><script data-card-contents-for-ri="136346" type="text/json">{"id":136346,"name":"Anemia","url":"https://www.academia.edu/Documents/in/Anemia?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13616055]'), work: {"id":13616055,"title":"The impact of body mass index on clinical outcomes after acute myocardial infarction","created_at":"2015-07-04T06:41:43.689-07:00","url":"https://www.academia.edu/13616055/The_impact_of_body_mass_index_on_clinical_outcomes_after_acute_myocardial_infarction?f_ri=49633","dom_id":"work_13616055","summary":"Background: Several studies indicated that an elevated body mass index (BMI) is associated with a lower rate of mortality in patients with acute myocardial infarction (AMI). However, the existence of the obesity paradox in AMI patients remains controversial. Methods: We examined the association of BMI and clinical outcomes in 2157 patient with AMI (mean followup of 26 months). BMI was categorized into 9 groups (b 18.5, 18.5 to 20.9, 21.0 to 23.4, 23.5 to 24.9, 25.0 to 26.4, 26.5 to 27.9, 28.0 to 29.9, 30.0 to 34.9, and ≥ 35.0 kg/m 2 ). Cox regression was used to calculate hazard ratios (HR) for the various BMI categories, adjusting for the clinical variables, left ventricular ejection fraction, and hemoglobin level. Results: BMI had a U-shaped association with mortality. Relative to the lowest mortality group (BMI of 26.5 to 27.9 kg/m 2 ), the adjusted HRs for mortality were increased only in the lower (HR 2.3; 95% CI 1.3-4.2) and upper (HR 1.8; 95% 1.2-2.9) BMI categories. There was a significant interaction between BMI and anemia (P = 0.0003) such that the U-shaped relationship between BMI and mortality was present mainly in patients with anemia. Patients in the lower and upper BMI categories and concomitant anemia had a striking increase in mortality (adjusted HR 5.1, 95% CI 1.9-11.7 and 3.2, 95% CI 1.5-7.0, respectively). Conclusion: Both obesity and underweight are associated with increased mortality in patients with AMI. The risk of mortality is particularly high among underweight and obese patients with anemia.","downloadable_attachments":[{"id":45151908,"asset_id":13616055,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32813596,"first_name":"Zaher","last_name":"Azzam","domain_name":"independent","page_name":"ZaherAzzam","display_name":"Zaher Azzam","profile_url":"https://independent.academia.edu/ZaherAzzam?f_ri=49633","photo":"/images/s65_no_pic.png"},{"id":32786363,"first_name":"Doron","last_name":"Aronson","domain_name":"csregistry","page_name":"DoronAronson","display_name":"Doron Aronson","profile_url":"https://csregistry.academia.edu/DoronAronson?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=49633","nofollow":true},{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":136346,"name":"Anemia","url":"https://www.academia.edu/Documents/in/Anemia?f_ri=49633","nofollow":true},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=49633"},{"id":172151,"name":"Acute Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Acute_Myocardial_Infarction?f_ri=49633"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=49633"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":353233,"name":"Body mass index (BMI)","url":"https://www.academia.edu/Documents/in/Body_mass_index_BMI_?f_ri=49633"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction?f_ri=49633"},{"id":398808,"name":"Coronary heart disease","url":"https://www.academia.edu/Documents/in/Coronary_heart_disease?f_ri=49633"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=49633"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=49633"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22379695" data-work_id="22379695" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22379695/Prevalence_of_chronic_heart_failure_in_Southwestern_Europe_the_EPICA_study">Prevalence of chronic heart failure in Southwestern Europe: the EPICA study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Aim: To estimate the prevalence of chronic heart failure (CHF) in mainland Portugal in 1998. Methods and population: A community-based epidemiological survey involving subjects attending primary care centres selected by a combined... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22379695" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Aim: To estimate the prevalence of chronic heart failure (CHF) in mainland Portugal in 1998. Methods and population: A community-based epidemiological survey involving subjects attending primary care centres selected by a combined two-stage sampling and stratified procedure. General practitioners (GPs) randomly selected in proportion to the population of the District, evaluated subjects attending primary care centres aged over 25 years, recruited consecutively and stratified by age. CHF cases were identified according to the Guidelines of the European Society of Cardiology for CHF diagnosis. Results: 5434 eligible subjects were evaluated by 365 GPs; 551 patients with CHF were identified. The overall prevalence and 95% CI of CHF in mainland Portugal is 4.36% (3.69-5.02%), 4.33% in males (3.19-5.46%), and 4.38% in females (3.64-5.13%). Age-specific CHF prevalence was as follows: 1.36% in the 25-49 years-old group (0.39-2.33%), 2.93% in the 50-59 years-old group (5.58-9.37%), 7.63% in the 60-69 years-old group (5.58-9.37%), 12.67% in the 70-79 years-old group (10.73-14.6%), and 16.14% in group over 80 years old (13.81-18.47%). The prevalence of CHF due to systolic dysfunction was 1.3% and the prevalence of CHF with normal systolic function was 1.7%. Conclusions: The overall prevalence of CHF in Portugal was slightly higher than that of other European studies and increases sharply with age. The prevalence of CHF due to systolic dysfunction is very similar to that reported by other recent European studies. The differences found may correspond to differences in methodology rather than actual differences in the population. 4 See Appendix A. 5 three decades, it is likely that the number of CHF cases has increased as a result of general improvement in health care, leading to increased life expectancy and progressive ageing of the Western population w2-6x. Moreover, the effective treatment of chronic cardiovascular disorders, such as ischemic heart disease and hypertension, and other relevant diseases, such as diabetes mellitus, may actually postpone rather than prevent CHF w7x.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22379695" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8a90fb3ddfc0b5178fbda90a27bc79a7" rel="nofollow" data-download="{"attachment_id":43008175,"asset_id":22379695,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43008175/download_file?st=MTczOTgwNzY0Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43836195" href="https://independent.academia.edu/FatimaCeia">Fatima Ceia</a><script data-card-contents-for-user="43836195" type="text/json">{"id":43836195,"first_name":"Fatima","last_name":"Ceia","domain_name":"independent","page_name":"FatimaCeia","display_name":"Fatima Ceia","profile_url":"https://independent.academia.edu/FatimaCeia?f_ri=49633","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22379695 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22379695"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22379695, container: ".js-paper-rank-work_22379695", }); 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$(".js-view-count[data-work-id=22379695]").text(description); $(".js-view-count-work_22379695").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22379695").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22379695"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="633" rel="nofollow" href="https://www.academia.edu/Documents/in/Primary_Care">Primary Care</a>, <script data-card-contents-for-ri="633" type="text/json">{"id":633,"name":"Primary Care","url":"https://www.academia.edu/Documents/in/Primary_Care?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="25469" rel="nofollow" href="https://www.academia.edu/Documents/in/Family_Practice">Family Practice</a>, <script data-card-contents-for-ri="25469" type="text/json">{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="44510" rel="nofollow" href="https://www.academia.edu/Documents/in/Portugal">Portugal</a>, <script data-card-contents-for-ri="44510" type="text/json">{"id":44510,"name":"Portugal","url":"https://www.academia.edu/Documents/in/Portugal?f_ri=49633","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="49633" rel="nofollow" href="https://www.academia.edu/Documents/in/Heart_Failure">Heart Failure</a><script data-card-contents-for-ri="49633" type="text/json">{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22379695]'), work: {"id":22379695,"title":"Prevalence of chronic heart failure in Southwestern Europe: the EPICA study","created_at":"2016-02-24T04:06:59.131-08:00","url":"https://www.academia.edu/22379695/Prevalence_of_chronic_heart_failure_in_Southwestern_Europe_the_EPICA_study?f_ri=49633","dom_id":"work_22379695","summary":"Aim: To estimate the prevalence of chronic heart failure (CHF) in mainland Portugal in 1998. Methods and population: A community-based epidemiological survey involving subjects attending primary care centres selected by a combined two-stage sampling and stratified procedure. General practitioners (GPs) randomly selected in proportion to the population of the District, evaluated subjects attending primary care centres aged over 25 years, recruited consecutively and stratified by age. CHF cases were identified according to the Guidelines of the European Society of Cardiology for CHF diagnosis. Results: 5434 eligible subjects were evaluated by 365 GPs; 551 patients with CHF were identified. The overall prevalence and 95% CI of CHF in mainland Portugal is 4.36% (3.69-5.02%), 4.33% in males (3.19-5.46%), and 4.38% in females (3.64-5.13%). Age-specific CHF prevalence was as follows: 1.36% in the 25-49 years-old group (0.39-2.33%), 2.93% in the 50-59 years-old group (5.58-9.37%), 7.63% in the 60-69 years-old group (5.58-9.37%), 12.67% in the 70-79 years-old group (10.73-14.6%), and 16.14% in group over 80 years old (13.81-18.47%). The prevalence of CHF due to systolic dysfunction was 1.3% and the prevalence of CHF with normal systolic function was 1.7%. Conclusions: The overall prevalence of CHF in Portugal was slightly higher than that of other European studies and increases sharply with age. The prevalence of CHF due to systolic dysfunction is very similar to that reported by other recent European studies. The differences found may correspond to differences in methodology rather than actual differences in the population. 4 See Appendix A. 5 three decades, it is likely that the number of CHF cases has increased as a result of general improvement in health care, leading to increased life expectancy and progressive ageing of the Western population w2-6x. Moreover, the effective treatment of chronic cardiovascular disorders, such as ischemic heart disease and hypertension, and other relevant diseases, such as diabetes mellitus, may actually postpone rather than prevent CHF w7x.","downloadable_attachments":[{"id":43008175,"asset_id":22379695,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43836195,"first_name":"Fatima","last_name":"Ceia","domain_name":"independent","page_name":"FatimaCeia","display_name":"Fatima Ceia","profile_url":"https://independent.academia.edu/FatimaCeia?f_ri=49633","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":633,"name":"Primary Care","url":"https://www.academia.edu/Documents/in/Primary_Care?f_ri=49633","nofollow":true},{"id":25469,"name":"Family Practice","url":"https://www.academia.edu/Documents/in/Family_Practice?f_ri=49633","nofollow":true},{"id":44510,"name":"Portugal","url":"https://www.academia.edu/Documents/in/Portugal?f_ri=49633","nofollow":true},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure?f_ri=49633","nofollow":true},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=49633"},{"id":131495,"name":"Heart","url":"https://www.academia.edu/Documents/in/Heart?f_ri=49633"},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=49633"},{"id":198747,"name":"Left Ventricular Dysfunction","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Dysfunction?f_ri=49633"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=49633"},{"id":411266,"name":"Chronic Heart Failure","url":"https://www.academia.edu/Documents/in/Chronic_Heart_Failure?f_ri=49633"},{"id":466522,"name":"General practitioner","url":"https://www.academia.edu/Documents/in/General_practitioner?f_ri=49633"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=49633"}]}, }) } })();</script></ul></li></ul></div></div></div><div class="u-taCenter Pagination"><ul class="pagination"><li class="next_page"><a href="/Documents/in/Heart_Failure?after=50%2C22379695" rel="next">Next</a></li><li class="last next"><a href="/Documents/in/Heart_Failure?page=last">Last »</a></li></ul></div></div><div class="hidden-xs hidden-sm"><div class="u-pl6x"><div style="width: 300px;"><div class="panel panel-flat u-mt7x"><div class="panel-heading u-p5x"><div class="u-tcGrayDark u-taCenter u-fw700 u-textUppercase">Related Topics</div></div><ul class="list-group"><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div 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