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class="firstHeading mw-first-heading"><span class="mw-page-title-main">Baricitinib</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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href="https://ca.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Catalan" lang="ca" hreflang="ca" data-title="Baricitinib" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Baricitinib" title="Baricitinib – German" lang="de" hreflang="de" data-title="Baricitinib" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Spanish" lang="es" hreflang="es" data-title="Baricitinib" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%D8%A7%D8%B1%DB%8C%D8%B3%DB%8C%D8%AA%DB%8C%D9%86%DB%8C%D8%A8" title="باریسیتینیب – Persian" lang="fa" hreflang="fa" data-title="باریسیتینیب" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Baricitinib" title="Baricitinib – French" lang="fr" hreflang="fr" data-title="Baricitinib" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Italian" lang="it" hreflang="it" data-title="Baricitinib" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%91%D7%A8%D7%99%D7%A6%D7%99%D7%98%D7%99%D7%A0%D7%99%D7%91" title="בריציטיניב – Hebrew" lang="he" hreflang="he" data-title="בריציטיניב" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%90%E3%83%AA%E3%82%B7%E3%83%81%E3%83%8B%E3%83%96" title="バリシチニブ – Japanese" lang="ja" hreflang="ja" data-title="バリシチニブ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AC%E0%AC%BE%E0%AC%B0%E0%AC%BF%E0%AC%B8%E0%AC%BF%E0%AC%9F%E0%AC%BF%E0%AC%A8%E0%AC%BF%E0%AC%AC" title="ବାରିସିଟିନିବ – Odia" lang="or" hreflang="or" data-title="ବାରିସିଟିନିବ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Baricitinibe" title="Baricitinibe – Portuguese" lang="pt" hreflang="pt" data-title="Baricitinibe" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Romanian" lang="ro" hreflang="ro" data-title="Baricitinib" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D0%B8%D1%86%D0%B8%D1%82%D0%B8%D0%BD%D0%B8%D0%B1" title="Барицитиниб – Russian" lang="ru" hreflang="ru" data-title="Барицитиниб" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Serbian" lang="sr" hreflang="sr" data-title="Baricitinib" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Baricitinib" title="Baricitinib – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Baricitinib" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D0%B0%D1%80%D1%96%D1%86%D0%B8%D1%82%D0%B8%D0%BD%D1%96%D0%B1" title="Баріцитиніб – 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.infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Baricitinib">Baricitinib</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><table style="width:100%; margin:0;"><tbody><tr> <td style="vertical-align:top; text-align:center; width:50%;"><span typeof="mw:File"><a href="/wiki/File:Baricitinib_structure.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Baricitinib_structure.svg/140px-Baricitinib_structure.svg.png" decoding="async" width="140" height="221" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Baricitinib_structure.svg/210px-Baricitinib_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Baricitinib_structure.svg/280px-Baricitinib_structure.svg.png 2x" data-file-width="512" data-file-height="809" /></a></span></td> <td style="vertical-align:top; text-align:center; width:50%;"><span typeof="mw:File"><a href="/wiki/File:Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png/140px-Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png" decoding="async" width="140" height="223" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png/210px-Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png/280px-Baricitinib-portrait-ligand-3JW-from-PDB-xtal-4W9X-Mercury-3D-balls.png 2x" data-file-width="1257" data-file-height="2000" /></a></span></td> </tr></tbody></table></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Olumiant, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">INCB28050, LY3009104</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/baricitinib.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a618033.html">a618033</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Baricitinib">Baricitinib</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> D<sup id="cite_ref-Olumiant_AU_PI_1-0" class="reference"><a href="#cite_note-Olumiant_AU_PI-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Drugs.com_pregnancy_2-0" class="reference"><a href="#cite_note-Drugs.com_pregnancy-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li>Use is contraindicated</li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">By mouth</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_L04" title="ATC code L04">L04AF02</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=L04AF02">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Olumiant_AU_PI_1-1" class="reference"><a href="#cite_note-Olumiant_AU_PI-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Boxed_warning" title="Boxed warning"><span style="border:thin solid black;">WARNING</span></a><sup id="cite_ref-FDA-AllBoxedWarnings_3-0" class="reference"><a href="#cite_note-FDA-AllBoxedWarnings-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>Rx-only<sup id="cite_ref-Olumiant_FDA_label_7-0" class="reference"><a href="#cite_note-Olumiant_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-Olumiant_EPAR_8-0" class="reference"><a href="#cite_note-Olumiant_EPAR-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">79%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">50%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data"><a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a> (<10%)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">12.5 hours</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">75% urine, 20% faeces</td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">2-[1-Ethylsulfonyl-3-[4-(7<i>H</i>-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1187594-09-7">1187594-09-7</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/44205240">44205240</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB11817">DB11817</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.26373084.html">26373084</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/ISP4442I3Y">ISP4442I3Y</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D10308">D10308</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:95341">CHEBI:95341</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL2105759">ChEMBL2105759</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB ligand</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>3JW (<span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=3JW">PDBe</a></span>, <span title="www.rcsb.org"><a rel="nofollow" class="external text" href="https://www.rcsb.org/ligand/3JW">RCSB PDB</a></span>)</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID30152228">DTXSID30152228</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4860707#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.219.080">100.219.080</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4860707#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>16</sub><span title="Hydrogen">H</span><sub>17</sub><span title="Nitrogen">N</span><sub>7</sub><span title="Oxygen">O</span><sub>2</sub><span title="Sulfur">S</span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002371420000000000♠"></span>371.42</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CCS%28%3DO%29%28%3DO%29N1CC%28CC%23N%29%28n2cc%28-c3ncnc4%5BnH%5Dccc34%29cn2%29C1">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:XUZMWHLSFXCVMG-UHFFFAOYSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Baricitinib</b>, sold under the brand name <b>Olumiant</b> among others, is an <a href="/wiki/Immunomodulatory" class="mw-redirect" title="Immunomodulatory">immunomodulatory</a> <a href="/wiki/Medication" title="Medication">medication</a> used for the treatment of <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Alopecia_areata" title="Alopecia areata">alopecia areata</a>, and <a href="/wiki/COVID-19" title="COVID-19">COVID-19</a>.<sup id="cite_ref-Olumiant_FDA_label_7-1" class="reference"><a href="#cite_note-Olumiant_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Olumiant_EPAR_8-1" class="reference"><a href="#cite_note-Olumiant_EPAR-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_snapshot_9-0" class="reference"><a href="#cite_note-FDA_snapshot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20220613_10-0" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It acts as an <a href="/wiki/Janus_kinase_inhibitor" title="Janus kinase inhibitor">inhibitor of janus kinase</a> (JAK), blocking the subtypes <a href="/wiki/JAK1" class="mw-redirect" title="JAK1">JAK1</a> and <a href="/wiki/JAK2" class="mw-redirect" title="JAK2">JAK2</a>.<sup id="cite_ref-CHMP_11-0" class="reference"><a href="#cite_note-CHMP-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>Baricitinib is approved for medical use in the European Union<sup id="cite_ref-Olumiant_EPAR_8-2" class="reference"><a href="#cite_note-Olumiant_EPAR-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> and in the United States.<sup id="cite_ref-FDA_snapshot_9-1" class="reference"><a href="#cite_note-FDA_snapshot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_12-0" class="reference"><a href="#cite_note-FDA_approval-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20220613_10-1" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In February 2017, baricitinib was approved for use in the European Union as a second-line therapy for moderate to severe active rheumatoid arthritis in adults, either alone or in combination with <a href="/wiki/Methotrexate" title="Methotrexate">methotrexate</a>.<sup id="cite_ref-EMA_13-0" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Olumiant_EPAR_8-3" class="reference"><a href="#cite_note-Olumiant_EPAR-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>In May 2018, the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) approved baricitinib for the treatment of adults with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.<sup id="cite_ref-FDA_approval_12-1" class="reference"><a href="#cite_note-FDA_approval-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_snapshot_9-2" class="reference"><a href="#cite_note-FDA_snapshot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Olumiant_FDA_label_7-2" class="reference"><a href="#cite_note-Olumiant_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>In May 2022, the FDA approved baricitinib for the treatment of COVID-19 in hospitalized adults requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO).<sup id="cite_ref-Olumiant_FDA_label_7-3" class="reference"><a href="#cite_note-Olumiant_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_FAQ_14-0" class="reference"><a href="#cite_note-FDA_FAQ-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20220510_15-0" class="reference"><a href="#cite_note-FDA_PR_20220510-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Baricitinib is the first immunomodulatory treatment for COVID-19 to receive FDA approval.<sup id="cite_ref-FDA_PR_20220510_15-1" class="reference"><a href="#cite_note-FDA_PR_20220510-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>In the United States, baricitinib is authorized under an <a href="/wiki/Emergency_use_authorization" class="mw-redirect" title="Emergency use authorization">emergency use authorization</a> (EUA) for the treatment of COVID-19 in hospitalized people aged 2 to less than 18 years of age who require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation.<sup id="cite_ref-FDA_FAQ_14-1" class="reference"><a href="#cite_note-FDA_FAQ-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>In June 2022, the FDA authorized baricitinib for the treatment of severe alopecia areata.<sup id="cite_ref-FDA_PR_20220613_10-2" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lilly_PR_20220613_16-0" class="reference"><a href="#cite_note-Lilly_PR_20220613-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=2" title="Edit section: Contraindications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>During pregnancy, the use of baricitinib is contraindicated.<sup id="cite_ref-Drugs.com_pregnancy_2-1" class="reference"><a href="#cite_note-Drugs.com_pregnancy-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EMA_13-1" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Side_effects">Side effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=3" title="Edit section: Side effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In studies, <a href="/wiki/Upper_respiratory_tract_infection" title="Upper respiratory tract infection">upper respiratory tract infections</a> and high blood <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> levels (<a href="/wiki/Hypercholesterolemia" title="Hypercholesterolemia">hypercholesterolemia</a>) occurred in more than 10% of participants. Less common side effects included other infections such as <a href="/wiki/Herpes_zoster" class="mw-redirect" title="Herpes zoster">herpes zoster</a>, <a href="/wiki/Herpes_simplex" class="mw-redirect" title="Herpes simplex">herpes simplex</a>, <a href="/wiki/Urinary_tract_infection" title="Urinary tract infection">urinary tract infections</a>, and <a href="/wiki/Gastroenteritis" title="Gastroenteritis">gastroenteritis</a>.<sup id="cite_ref-EMA_13-2" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=4" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Being <a href="/wiki/Metabolized" class="mw-redirect" title="Metabolized">metabolized</a> only to a small extent, the substance has a low potential for interactions. In studies, inhibitors of the liver enzymes <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>, <a href="/wiki/CYP2C19" title="CYP2C19">CYP2C19</a>, and <a href="/wiki/CYP2C9" title="CYP2C9">CYP2C9</a>, as well as the CYP3A4 <a href="/wiki/Enzyme_inducer" title="Enzyme inducer">inducer</a> <a href="/wiki/Rifampicin" title="Rifampicin">rifampicin</a>, had no relevant influence on baricitinib concentrations in the bloodstream. While baricitinib blocks a number of <a href="/wiki/Transporter_protein" class="mw-redirect" title="Transporter protein">transporter proteins</a> <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i>, clinically relevant interactions via this mechanism are considered very unlikely, except perhaps for the cation transporter <a href="/wiki/SLC22A1" title="SLC22A1">SLC22A1</a> (OCT1).<sup id="cite_ref-EMA_13-3" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>An additive effect with other <a href="/wiki/Immunosuppressant" class="mw-redirect" title="Immunosuppressant">immunosuppressants</a> cannot be excluded.<sup id="cite_ref-EMA_13-4" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=5" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Mechanism_of_action">Mechanism of action</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=6" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Further information: <a href="/wiki/Janus_kinase_inhibitor#Mechanism_of_action" title="Janus kinase inhibitor">Janus kinase inhibitor § Mechanism of action</a></div> <p>Baricitinib is a Janus kinase (JAK) inhibitor that reversibly inhibits <a href="/wiki/Janus_kinase_1" title="Janus kinase 1">Janus kinase 1</a> with a <a href="/wiki/Half_maximal_inhibitory_concentration" class="mw-redirect" title="Half maximal inhibitory concentration">half maximal inhibitory concentration</a> (IC<sub>50</sub>) of 5.9 <a href="/wiki/Nanomolar" class="mw-redirect" title="Nanomolar">nM</a> and <a href="/wiki/Janus_kinase_2" title="Janus kinase 2">Janus kinase 2</a> with an IC<sub>50</sub> of 5.7 nM. <a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">Tyrosine kinase 2</a>, which belongs to the same enzyme family, is affected less (IC<sub>50</sub> = 53 nM), and <a href="/wiki/Janus_kinase_3" title="Janus kinase 3">Janus kinase 3</a> far less (IC<sub>50</sub> > 400 nM). Via a <a href="/wiki/Signal_transduction" title="Signal transduction">signal transduction</a> pathway involving <a href="/wiki/STAT_protein" title="STAT protein">STAT proteins</a>, this ultimately modulates <a href="/wiki/Gene_expression" title="Gene expression">gene expression</a> in immunological cells.<sup id="cite_ref-EMA_13-5" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Other JAK inhibitors include <a href="/wiki/Tofacitinib" title="Tofacitinib">tofacitinib</a>, which is indicated for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis;<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-November2012_18-0" class="reference"><a href="#cite_note-November2012-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Fedratinib" title="Fedratinib">fedratinib</a>,<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Ruxolitinib" title="Ruxolitinib">ruxolitinib</a>.<sup id="cite_ref-Mesa2010_20-0" class="reference"><a href="#cite_note-Mesa2010-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=7" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The substance is quickly absorbed from the gut with an absolute <a href="/wiki/Bioavailability" title="Bioavailability">bioavailability</a> of 79%. It reaches highest <a href="/wiki/Blood_plasma" title="Blood plasma">blood plasma</a> levels after about an hour; in different individuals the time to reach this level ranges from 0.5 to 3 hours. Food intake has no relevant influence on the drug's pharmacokinetics. 50% of the circulating baricitinib are bound to blood <a href="/wiki/Plasma_protein" title="Plasma protein">plasma proteins</a>.<sup id="cite_ref-EMA_13-6" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Less than 10% of the substance is metabolized to four different oxidation products by CYP3A4; the rest is left unchanged. <a href="/wiki/Elimination_half-life" class="mw-redirect" title="Elimination half-life">Elimination half-life</a> is 12.5 hours on average. About 75% is eliminated via the urine, and 20% via the <a href="/wiki/Faeces" class="mw-redirect" title="Faeces">faeces</a>.<sup id="cite_ref-EMA_13-7" class="reference"><a href="#cite_note-EMA-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=8" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Baricitinib was discovered by <a href="/wiki/Incyte" title="Incyte">Incyte</a> and licensed to <a href="/wiki/Eli_Lilly_and_Company" title="Eli Lilly and Company">Eli Lilly</a>.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=9" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Legal_status">Legal status</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=10" title="Edit section: Legal status"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In January 2016, Eli Lilly submitted a <a href="/wiki/New_drug_application" class="mw-redirect" title="New drug application">new drug application</a> to the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) for the approval of baricitinib to treat moderately-to-severely active rheumatoid arthritis.<sup id="cite_ref-NDA_23-0" class="reference"><a href="#cite_note-NDA-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>In December 2016, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) recommended the approval of baricitinib as a therapy for rheumatoid arthritis.<sup id="cite_ref-CHMP_11-1" class="reference"><a href="#cite_note-CHMP-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> European Union approval was granted in February 2017.<sup id="cite_ref-Olumiant_EPAR_8-4" class="reference"><a href="#cite_note-Olumiant_EPAR-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Despite widespread expectations that the FDA would approve baricitinib for rheumatoid arthritis,<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> in April 2017, the FDA issued a rejection, citing concerns about dosing and safety.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p><p>In May 2018, baricitinib was approved in the United States for the treatment of rheumatoid arthritis.<sup id="cite_ref-FDA_snapshot_9-3" class="reference"><a href="#cite_note-FDA_snapshot-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_approval_12-2" class="reference"><a href="#cite_note-FDA_approval-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20220613_10-3" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>In March 2020, the US FDA granted <a href="/wiki/Breakthrough_therapy" title="Breakthrough therapy">breakthrough therapy</a> designation to baricitinib for the treatment of <a href="/wiki/Alopecia_areata" title="Alopecia areata">alopecia areata</a><sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> and granted approval in June 2022.<sup id="cite_ref-Lilly_PR_20220613_16-1" class="reference"><a href="#cite_note-Lilly_PR_20220613-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>The efficacy and safety of baricitinib in alopecia areata was studied in two randomized, double-blind, placebo-controlled trials (Trial AA-1 and Trial AA-2) with participants who had at least 50% scalp hair loss as measured by the Severity of Alopecia Tool for more than six months.<sup id="cite_ref-FDA_PR_20220613_10-4" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Participants in these trials received either a placebo, 2 milligrams of baricitinib, or 4 milligrams of baricitinib every day.<sup id="cite_ref-FDA_PR_20220613_10-5" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The primary measurement of efficacy for both trials was the proportion of participants who achieved at least 80% scalp hair coverage at week 36.<sup id="cite_ref-FDA_PR_20220613_10-6" class="reference"><a href="#cite_note-FDA_PR_20220613-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=11" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As of August 2016<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Baricitinib&action=edit">[update]</a></sup>, 31 clinical trials had been registered for baricitinib of which 24 had completed,<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> and 4 of 6 phase 3 trials had completed.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Manual_of_Style/Dates_and_numbers#Chronological_items" title="Wikipedia:Manual of Style/Dates and numbers"><span title="The date of the event predicted near this tag has passed. (April 2020)">needs update</span></a></i>]</sup> </p><p>As of March 2022<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Baricitinib&action=edit">[update]</a></sup>, a phase III clinical trial showed hair regrowth for those with <a href="/wiki/Alopecia_areata" title="Alopecia areata">alopecia areata</a>.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="COVID-19">COVID-19</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=12" title="Edit section: COVID-19"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><span class="anchor" id="COVID-19_research"></span> </p><p>In April 2020, Lilly announced they were investigating the use of baricitinib for treating people with <a href="/wiki/COVID-19" title="COVID-19">COVID-19</a>. The drug's anti-inflammatory activity was expected to act on the inflammatory cascade associated with COVID-19.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p><p>In April and June 2020, the first two studies of baricitinib prescribed for hospitalized people with COVID-19 were published online.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> Then in November 2020, published research showed baricitinib was beneficial in treating people with COVID-19. According to the paper "mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication and the <a href="/wiki/Cytokine_storm" title="Cytokine storm">cytokine storm</a>, and is associated with beneficial outcomes including in severely ill elderly people".<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p><p>In a clinical trial of hospitalized people with COVID-19, baricitinib, in combination with remdesivir, was shown to reduce time to recovery within 29 days after initiating treatment compared to participants who received a placebo with remdesivir.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p><p>The data supporting the US <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) <a href="/wiki/Emergency_use_authorization" class="mw-redirect" title="Emergency use authorization">emergency use authorization</a> (EUA) for baricitinib combined with remdesivir was based on a randomized, double-blind, placebo-controlled clinical trial (ACTT-2), which was conducted by the US <a href="/wiki/National_Institute_of_Allergy_and_Infectious_Diseases" title="National Institute of Allergy and Infectious Diseases">National Institute of Allergy and Infectious Diseases</a> (NIAID).<sup id="cite_ref-FDA_PR_20201119_37-0" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_CDER_Review_38-0" class="reference"><a href="#cite_note-FDA_CDER_Review-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> This clinical trial evaluated whether baricitinib impacted how long it took for subjects who were also taking remdesivir to recover from COVID-19.<sup id="cite_ref-FDA_PR_20201119_37-1" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> The trial followed participants for 29 days and included 1,033 participants with moderate or severe COVID-19; 515 participants received baricitinib plus remdesivir, and 518 participants received placebo plus remdesivir.<sup id="cite_ref-FDA_PR_20201119_37-2" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Recovery was defined as either being discharged from the hospital or being hospitalized but not requiring supplemental oxygen and no longer requiring ongoing medical care.<sup id="cite_ref-FDA_PR_20201119_37-3" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> The median time to recovery from COVID-19 was seven days for baricitinib plus remdesivir and eight days for placebo plus remdesivir.<sup id="cite_ref-FDA_PR_20201119_37-4" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> The odds of a patient's condition progressing to death or being ventilated at day 29 was 31% lower in the baricitinib plus remdesivir group versus the placebo plus remdesivir group.<sup id="cite_ref-FDA_PR_20201119_37-5" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> The odds of clinical improvement at day 15 was 30% higher in the baricitinib plus remdesivir group versus the placebo plus remdesivir group.<sup id="cite_ref-FDA_PR_20201119_37-6" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> For all of these endpoints, the effects were statistically significant.<sup id="cite_ref-FDA_PR_20201119_37-7" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> The EUA was issued to <a href="/wiki/Eli_Lilly_and_Company" title="Eli Lilly and Company">Eli Lilly and Company</a>.<sup id="cite_ref-FDA_PR_20201119_37-8" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p><p>In November 2020, the World Health Organization (WHO) updated its guideline on therapeutics for COVID-19 to include a conditional recommendation against the use of remdesivir, triggered by results from the WHO <a href="/wiki/Solidarity_trial" title="Solidarity trial">Solidarity trial</a>.<sup id="cite_ref-WHO_guidelines_39-0" class="reference"><a href="#cite_note-WHO_guidelines-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-who-lg_40-0" class="reference"><a href="#cite_note-who-lg-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p><p>In November 2020, the FDA issued an <a href="/wiki/Emergency_use_authorization" class="mw-redirect" title="Emergency use authorization">emergency use authorization</a> (EUA) for the combination of baricitinib with <a href="/wiki/Remdesivir" title="Remdesivir">remdesivir</a>, for the treatment of suspected or laboratory confirmed <a href="/wiki/COVID-19" title="COVID-19">COVID-19</a> in hospitalized people aged two years of age or older requiring supplemental oxygen, invasive mechanical ventilation, or <a href="/wiki/Extracorporeal_membrane_oxygenation" title="Extracorporeal membrane oxygenation">extracorporeal membrane oxygenation</a> (ECMO).<sup id="cite_ref-FDA_EUA_41-0" class="reference"><a href="#cite_note-FDA_EUA-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_Fact_Sheet_42-0" class="reference"><a href="#cite_note-FDA_EUA_Fact_Sheet-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20201119_37-9" class="reference"><a href="#cite_note-FDA_PR_20201119-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p><p>Then in September 2021, the largest randomized, placebo-controlled trial of hospitalized people with COVID-19 to date, COV-BARRIER, was published.<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> This trial randomized 1525 participants to either baricitinib or placebo. Nearly 80% of participants were receiving systemic corticosteroids at enrollment. There was an absolute risk reduction of 2.7 percent in the primary endpoint of progression to high-flow oxygen, non-invasive ventilation, invasive mechanical ventilation, or death by day 28. The 38.2% statistically significant reduction in all-cause 28-day mortality for participants receiving baricitinib compared to placebo was the largest mortality reduction to date and maintained at 60 days. This translates into one additional death prevented for every 20 participants treated with baricitinib. The frequencies of serious adverse events were lower for participants receiving baricitinib compared to those receiving placebo.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (October 2022)">citation needed</span></a></i>]</sup> </p><p>As of April 2021<sup class="plainlinks noexcerpt noprint asof-tag update" style="display:none;"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Baricitinib&action=edit">[update]</a></sup>, the <a href="/wiki/Committee_for_Medicinal_Products_for_Human_Use" title="Committee for Medicinal Products for Human Use">Committee for Medicinal Products for Human Use</a> (CHMP) of the <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA) is evaluating the use of baricitinib to include treatment of COVID-19 in hospitalized people from ten years of age who require supplemental oxygen.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> </p><p>In July 2021, the FDA revised the EUA for baricitinib authorizing it alone for the treatment of COVID-19 in hospitalized people aged two years of age or older requiring supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO).<sup id="cite_ref-FDA_EUA_41-1" class="reference"><a href="#cite_note-FDA_EUA-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_EUA_Fact_Sheet_42-1" class="reference"><a href="#cite_note-FDA_EUA_Fact_Sheet-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FDA_PR_20210730_45-0" class="reference"><a href="#cite_note-FDA_PR_20210730-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> Under the revised EUA, baricitinib is not required to be administered with remdesivir.<sup id="cite_ref-FDA_PR_20210730_45-1" class="reference"><a href="#cite_note-FDA_PR_20210730-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p><p>As of January 2022, the World Health Organization recommends baricitinib for people with severe or critical COVID-19.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> Thereafter in February 2022, an exploratory randomized, placebo-controlled trial of participants receiving invasive mechanical ventilation or extracorporeal membrane oxygenation were randomly to baricitinib or placebo. There was a 46% statistically significant relative reduction in all-cause mortality for participants receiving baricitinib compared to those receiving placebo at 28 days which was sustained at 60 days.<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p><p>Then in May 2022, the FDA approved use of baricitinib for the treatment of adults hospitalized with COVID-19 who require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation with a recommended dose of 4 mg once daily for 14 days or until hospital discharge, whichever happens first.<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p><p>In March 2022, the <a href="/wiki/RECOVERY_Trial" title="RECOVERY Trial">RECOVERY trial</a> reported that the use of baricitinib cut the risk of death by about a fifth in about 12,000 participants.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=13" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-Olumiant_AU_PI-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-Olumiant_AU_PI_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Olumiant_AU_PI_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2018-PI-01225-1">"Olumiant Product Information"</a> <span class="cs1-format">(PDF)</span>. <i><a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">Therapeutic Goods Administration</a> (TGA)</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210920213103/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2018-PI-01225-1">Archived</a> from the original on 20 September 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">12 June</span> 2021</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Therapeutic+Goods+Administration+%28TGA%29&rft.atitle=Olumiant+Product+Information&rft_id=https%3A%2F%2Fwww.ebs.tga.gov.au%2Febs%2Fpicmi%2Fpicmirepository.nsf%2Fpdf%3FOpenAgent%26id%3DCP-2018-PI-01225-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-Drugs.com_pregnancy-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs.com_pregnancy_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs.com_pregnancy_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/pregnancy/baricitinib.html">"Baricitinib (Olumiant) Use During Pregnancy"</a>. <i>Drugs.com</i>. 8 November 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200626063309/https://www.drugs.com/pregnancy/baricitinib.html">Archived</a> from the original on 26 June 2020<span class="reference-accessdate">. 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Retrieved <span class="nowrap">29 May</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Summary+Basis+of+Decision+%28SBD%29+for+Olumiant&rft.date=2014-10-23&rft_id=https%3A%2F%2Fhpr-rps.hres.ca%2Freg-content%2Fsummary-basis-decision-detailTwo.php%3FlinkID%3DSBD00410%26lang%3Den&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dhpp.hpfb-dgpsa.ca/review-documents/resource/RDS1710876504060">"Regulatory Decision Summary for Olumiant"</a>. <i>Drug and Health Products Portal</i>. 26 January 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">2 April</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drug+and+Health+Products+Portal&rft.atitle=Regulatory+Decision+Summary+for+Olumiant&rft.date=2024-01-26&rft_id=https%3A%2F%2Fdhpp.hpfb-dgpsa.ca%2Freview-documents%2Fresource%2FRDS1710876504060&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-Olumiant_FDA_label-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-Olumiant_FDA_label_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Olumiant_FDA_label_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Olumiant_FDA_label_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Olumiant_FDA_label_7-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=866e9f35-9035-4581-a4b1-75a621ab55cf">"Olumiant- baricitinib tablet, film coated"</a>. <i>DailyMed</i>. 13 November 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200927111424/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=866e9f35-9035-4581-a4b1-75a621ab55cf">Archived</a> from the original on 27 September 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">16 March</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Olumiant-+baricitinib+tablet%2C+film+coated&rft.date=2019-11-13&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3D866e9f35-9035-4581-a4b1-75a621ab55cf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-Olumiant_EPAR-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-Olumiant_EPAR_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Olumiant_EPAR_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Olumiant_EPAR_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Olumiant_EPAR_8-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Olumiant_EPAR_8-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/medicines/human/EPAR/olumiant">"Olumiant EPAR"</a>. <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 3 December 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210825064838/https://www.ema.europa.eu/en/medicines/human/EPAR/olumiant">Archived</a> from the original on 25 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">17 March</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Olumiant+EPAR&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2019-12-03&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fmedicines%2Fhuman%2FEPAR%2Folumiant&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span> Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</span> </li> <li id="cite_note-FDA_snapshot-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_snapshot_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_snapshot_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_snapshot_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-FDA_snapshot_9-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-olumiant">"Drug Trials Snapshots: Olumiant"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 31 May 2018. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20191213230735/https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-olumiant">Archived</a> from the original on 13 December 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">16 March</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Drug+Trials+Snapshots%3A+Olumiant&rft.date=2018-05-31&rft_id=http%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fdrug-approvals-and-databases%2Fdrug-trials-snapshots-olumiant&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-FDA_PR_20220613-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_PR_20220613_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-FDA_PR_20220613_10-6"><sup><i><b>g</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation pressrelease cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-systemic-treatment-alopecia-areata">"FDA Approves First Systemic Treatment for Alopecia Areata"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i> (Press release). 13 June 2022. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220614051142/https://www.fda.gov/news-events/press-announcements/fda-approves-first-systemic-treatment-alopecia-areata">Archived</a> from the original on 14 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">13 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=FDA+Approves+First+Systemic+Treatment+for+Alopecia+Areata&rft.date=2022-06-13&rft_id=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Ffda-approves-first-systemic-treatment-alopecia-areata&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span> <span class="noviewer" typeof="mw:File"><span><img alt="Public Domain" src="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/12px-PD-icon.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/18px-PD-icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/6/62/PD-icon.svg/24px-PD-icon.svg.png 2x" data-file-width="196" data-file-height="196" /></span></span> This article incorporates text from this source, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</span> </li> <li id="cite_note-CHMP-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-CHMP_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-CHMP_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/004085/WC500218183.pdf">"Summary of opinion for Olumiant"</a> <span class="cs1-format">(PDF)</span>. <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a> (EMA). 15 December 2016. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180315212105/http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/004085/WC500218183.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 15 March 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">18 December</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Summary+of+opinion+for+Olumiant&rft.pub=European+Medicines+Agency+%28EMA%29&rft.date=2016-12-15&rft_id=http%3A%2F%2Fwww.ema.europa.eu%2Fdocs%2Fen_GB%2Fdocument_library%2FSummary_of_opinion_-_Initial_authorisation%2Fhuman%2F004085%2FWC500218183.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-FDA_approval-12"><span class="mw-cite-backlink">^ <a href="#cite_ref-FDA_approval_12-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-FDA_approval_12-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-FDA_approval_12-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/207924Orig1s000TOC.cfm">"Drug Approval Package: Olumiant (baricitinib)"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 5 July 2018. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200428001853/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/207924Orig1s000TOC.cfm">Archived</a> from the original on 28 April 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">16 March</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Drug+Approval+Package%3A+Olumiant+%28baricitinib%29&rft.date=2018-07-05&rft_id=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Fnda%2F2018%2F207924Orig1s000TOC.cfm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> <li id="cite_note-EMA-13"><span class="mw-cite-backlink">^ <a href="#cite_ref-EMA_13-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-EMA_13-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-EMA_13-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-EMA_13-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-EMA_13-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-EMA_13-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-EMA_13-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-EMA_13-7"><sup><i><b>h</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf">"Olumiant: EPAR – Product Information"</a> <span class="cs1-format">(PDF)</span>. <a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a>. 13 February 2017. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20180712201644/http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 12 July 2018<span class="reference-accessdate">. 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(RECOVERY Collaborative Group) (July 2022). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333998">"Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis"</a>. <i>Lancet</i>. <b>400</b> (10349): 359–368. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0140-6736%2822%2901109-6">10.1016/S0140-6736(22)01109-6</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333998">9333998</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/35908569">35908569</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:247216504">247216504</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Baricitinib+in+patients+admitted+to+hospital+with+COVID-19+%28RECOVERY%29%3A+a+randomised%2C+controlled%2C+open-label%2C+platform+trial+and+updated+meta-analysis&rft.volume=400&rft.issue=10349&rft.pages=359-368&rft.date=2022-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9333998%23id-name%3DPMC&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A247216504%23id-name%3DS2CID&rft_id=info%3Apmid%2F35908569&rft_id=info%3Adoi%2F10.1016%2FS0140-6736%2822%2901109-6&rft.aulast=Abani&rft.aufirst=O&rft.au=Abbas%2C+A&rft.au=Abbas%2C+F&rft.au=Abbas%2C+J&rft.au=Abbas%2C+K&rft.au=Abbas%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9333998&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Baricitinib&action=edit&section=14" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCingolaniTummoloMontemurroGremese2020" class="citation journal cs1">Cingolani A, Tummolo AM, Montemurro G, Gremese E, Larosa L, Cipriani MC, et al. (October 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340855">"Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab"</a>. <i>Infection</i>. <b>48</b> (5): 767–771. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs15010-020-01476-7">10.1007/s15010-020-01476-7</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340855">7340855</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32642806">32642806</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Infection&rft.atitle=Baricitinib+as+rescue+therapy+in+a+patient+with+COVID-19+with+no+complete+response+to+sarilumab&rft.volume=48&rft.issue=5&rft.pages=767-771&rft.date=2020-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7340855%23id-name%3DPMC&rft_id=info%3Apmid%2F32642806&rft_id=info%3Adoi%2F10.1007%2Fs15010-020-01476-7&rft.aulast=Cingolani&rft.aufirst=A&rft.au=Tummolo%2C+AM&rft.au=Montemurro%2C+G&rft.au=Gremese%2C+E&rft.au=Larosa%2C+L&rft.au=Cipriani%2C+MC&rft.au=Pasciuto%2C+G&rft.au=Liperoti%2C+R&rft.au=Murri%2C+R&rft.au=Pirronti%2C+T&rft.au=Cauda%2C+R&rft.au=Fantoni%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7340855&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJorgensenTseBurryDresser2020" class="citation journal cs1">Jorgensen SC, Tse CL, Burry L, Dresser LD (August 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323235">"Baricitinib: A Review of Pharmacology, Safety, and Emerging Clinical Experience in COVID-19"</a>. <i>Pharmacotherapy</i>. <b>40</b> (8): 843–856. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fphar.2438">10.1002/phar.2438</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323235">7323235</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32542785">32542785</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Baricitinib%3A+A+Review+of+Pharmacology%2C+Safety%2C+and+Emerging+Clinical+Experience+in+COVID-19&rft.volume=40&rft.issue=8&rft.pages=843-856&rft.date=2020-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7323235%23id-name%3DPMC&rft_id=info%3Apmid%2F32542785&rft_id=info%3Adoi%2F10.1002%2Fphar.2438&rft.aulast=Jorgensen&rft.aufirst=SC&rft.au=Tse%2C+CL&rft.au=Burry%2C+L&rft.au=Dresser%2C+LD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7323235&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABaricitinib" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKalilPattersonMehtaTomashek2021" class="citation journal cs1">Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, et al. 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class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangZhangQiaoZhang2020" class="citation journal cs1">Zhang X, Zhang Y, Qiao W, Zhang J, Qi Z (September 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328558">"Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19"</a>. <i>International Immunopharmacology</i>. <b>86</b>: 106749. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.intimp.2020.106749">10.1016/j.intimp.2020.106749</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328558">7328558</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32645632">32645632</a>.</cite><span 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navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Immunosuppressants" title="Template:Immunosuppressants"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Immunosuppressants" title="Template talk:Immunosuppressants"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Immunosuppressants" title="Special:EditPage/Template:Immunosuppressants"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Immunosuppressive_drugs_/_Immunosuppressants_(L04)" style="font-size:114%;margin:0 4em"><a href="/wiki/Immunosuppressive_drug" title="Immunosuppressive drug">Immunosuppressive drugs</a> / <a href="/wiki/Immunosuppression" title="Immunosuppression">Immunosuppressants</a> (<a href="/wiki/ATC_code_L04" title="ATC code L04">L04</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular<br />(initiation)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antimetabolite" title="Antimetabolite">Antimetabolites</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Purine_synthesis_inhibitor" class="mw-redirect" title="Purine synthesis inhibitor">purine synthesis inhibitors</a></i> <ul><li><a href="/wiki/Azathioprine" title="Azathioprine">Azathioprine</a></li> <li><a href="/wiki/Mycophenolic_acid" title="Mycophenolic acid">Mycophenolic acid</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Dihydroorotate_dehydrogenase" title="Dihydroorotate dehydrogenase">dihydroorotate dehydrogenase</a></i> inhibitors <ul><li><a href="/wiki/Leflunomide" title="Leflunomide">Leflunomide</a></li> <li><a href="/wiki/Teriflunomide" title="Teriflunomide">Teriflunomide</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Antifolate" title="Antifolate">antifolate</a></i> <ul><li><a href="/wiki/Methotrexate" title="Methotrexate">Methotrexate</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Macrolide" title="Macrolide">Macrolides</a>/<br />other <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> inhibitors</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/FKBP" title="FKBP">FKBP</a>/<a href="/wiki/Cyclophilin" title="Cyclophilin">Cyclophilin</a>/<a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></i> <ul><li><a href="/wiki/Ciclosporin" title="Ciclosporin">Ciclosporin</a></li> <li><a href="/wiki/Pimecrolimus" title="Pimecrolimus">Pimecrolimus</a></li> <li><a href="/wiki/Tacrolimus" title="Tacrolimus">Tacrolimus</a></li> <li><a href="/wiki/Voclosporin" title="Voclosporin">Voclosporin</a></li></ul></li></ul> <ul><li><a href="/wiki/Abetimus" title="Abetimus">Abetimus</a></li> <li><a href="/wiki/Gusperimus" title="Gusperimus">Gusperimus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunomodulatory_imide_drug" class="mw-redirect" title="Immunomodulatory imide drug">IMiDs</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lenalidomide" title="Lenalidomide">Lenalidomide</a></li> <li><a href="/wiki/Pomalidomide" title="Pomalidomide">Pomalidomide</a></li> <li><a href="/wiki/Thalidomide" title="Thalidomide">Thalidomide</a></li> <li><i><a href="/wiki/PDE4_inhibitor" title="PDE4 inhibitor">PDE4 inhibitor</a></i> <ul><li><a href="/wiki/Apremilast" title="Apremilast">Apremilast</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Intracellular<br />(reception)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1 receptor antagonists</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MTOR" title="MTOR">mTOR</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Everolimus" title="Everolimus">Everolimus</a></li> <li><a href="/wiki/Ridaforolimus" title="Ridaforolimus">Ridaforolimus</a></li> <li><a href="/wiki/Sirolimus" title="Sirolimus">Sirolimus</a></li> <li><a href="/wiki/Temsirolimus" title="Temsirolimus">Temsirolimus</a></li> <li><a href="/wiki/Umirolimus" title="Umirolimus">Umirolimus</a></li> <li><a href="/wiki/Zotarolimus" title="Zotarolimus">Zotarolimus</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Extracellular</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antibody" title="Antibody">Antibodies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Serum target<br />(noncellular)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Complement_component_5" title="Complement component 5">Complement component 5</a></i> <ul><li><a href="/wiki/Eculizumab" title="Eculizumab">Eculizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/TNF_inhibitor" title="TNF inhibitor">TNF</a></i> <ul><li><a href="/wiki/Adalimumab" title="Adalimumab">Adalimumab</a></li> <li><a href="/wiki/Afelimomab" title="Afelimomab">Afelimomab</a></li> <li><a href="/wiki/Certolizumab_pegol" title="Certolizumab pegol">Certolizumab pegol</a></li> <li><a href="/wiki/Golimumab" title="Golimumab">Golimumab</a></li> <li><a href="/wiki/Infliximab" title="Infliximab">Infliximab</a></li> <li><a href="/wiki/Nerelimomab" title="Nerelimomab">Nerelimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></i> <ul><li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/w/index.php?title=Netakimab&action=edit&redlink=1" class="new" title="Netakimab (page does not exist)">Netakimab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></i> <ul><li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Immunoglobulin_E" title="Immunoglobulin E">Immunoglobulin E</a></i> <ul><li><a href="/wiki/Omalizumab" title="Omalizumab">Omalizumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interferon" title="Interferon">Interferon</a></i> <ul><li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a></i> <ul><li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_12" title="Interleukin 12">IL-12</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>, and <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a></i> <ul><li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17A</a></i> <ul><li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Cellular<br />target</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a></i> <ul><li><a href="/wiki/Muromonab-CD3" title="Muromonab-CD3">Muromonab-CD3</a></li> <li><a href="/wiki/Otelixizumab" title="Otelixizumab">Otelixizumab</a></li> <li><a href="/wiki/Teplizumab" title="Teplizumab">Teplizumab</a></li> <li><a href="/wiki/Visilizumab" title="Visilizumab">Visilizumab</a></li></ul></li> <li><i><a href="/wiki/CD4" title="CD4">CD4</a></i> <ul><li><a href="/wiki/Clenoliximab" title="Clenoliximab">Clenoliximab</a></li> <li><a href="/wiki/Keliximab" title="Keliximab">Keliximab</a></li> <li><a href="/wiki/Zanolimumab" title="Zanolimumab">Zanolimumab</a></li></ul></li> <li><i><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">CD11a</a></i> <ul><li><a href="/wiki/Efalizumab" title="Efalizumab">Efalizumab</a></li></ul></li> <li><i><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></i> <ul><li><a href="/wiki/Erlizumab" title="Erlizumab">Erlizumab</a></li></ul></li> <li><i><a href="/wiki/CD20" title="CD20">CD20</a></i> <ul><li><a href="/wiki/Obinutuzumab" title="Obinutuzumab">Obinutuzumab</a></li> <li><a href="/wiki/Ocrelizumab" title="Ocrelizumab">Ocrelizumab</a> (<a href="/wiki/Ocrelizumab/hyaluronidase" title="Ocrelizumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li> <li><a href="/wiki/Rituximab" title="Rituximab">Rituximab</a></li> <li><a href="/wiki/Ublituximab" title="Ublituximab">Ublituximab</a></li></ul></li> <li><i><a href="/wiki/CD23" title="CD23">CD23</a></i> <ul><li><a href="/wiki/Gomiliximab" class="mw-redirect" title="Gomiliximab">Gomiliximab</a></li> <li><a href="/wiki/Lumiliximab" title="Lumiliximab">Lumiliximab</a></li></ul></li> <li><i><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></i> <ul><li><a href="/wiki/Teneliximab" title="Teneliximab">Teneliximab</a></li> <li><a href="/wiki/Toralizumab" title="Toralizumab">Toralizumab</a></li></ul></li> <li><i><a href="/wiki/L-selectin" title="L-selectin">CD62L/L-selectin</a></i> <ul><li><a href="/wiki/Aselizumab" title="Aselizumab">Aselizumab</a></li></ul></li> <li><i><a href="/wiki/CD80" title="CD80">CD80</a></i> <ul><li><a href="/wiki/Galiximab" title="Galiximab">Galiximab</a></li></ul></li> <li><i><a href="/wiki/Basigin" title="Basigin">CD147/Basigin</a></i> <ul><li><a href="/wiki/Gavilimomab" title="Gavilimomab">Gavilimomab</a></li></ul></li> <li><i><a href="/wiki/CD154" title="CD154">CD154</a></i> <ul><li><a href="/wiki/Frexalimab" title="Frexalimab">Frexalimab</a></li> <li><a href="/wiki/Ruplizumab" title="Ruplizumab">Ruplizumab</a></li></ul></li></ul> <ul><li><i>BLyS</i> <ul><li><a href="/wiki/Belimumab" title="Belimumab">Belimumab</a></li></ul></li> <li><i><a href="/wiki/Chloramphenicol_acetyltransferase" title="Chloramphenicol acetyltransferase">CAT</a></i> <ul><li><a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul></li> <li><i><a href="/wiki/Integrin" title="Integrin">Integrin</a></i> <ul><li><a href="/wiki/Natalizumab" title="Natalizumab">Natalizumab</a></li> <li><a href="/wiki/Vedolizumab" title="Vedolizumab">Vedolizumab</a></li></ul></li> <li><i><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">Interleukin-6 receptor</a></i> <ul><li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li></ul></li> <li><i><a href="/wiki/Lymphocyte_function-associated_antigen_1" title="Lymphocyte function-associated antigen 1">LFA-1</a></i> <ul><li><a href="/wiki/Odulimomab" title="Odulimomab">Odulimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/IL-2_receptor" title="IL-2 receptor">IL-2 receptor/CD25</a></i> <ul><li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul></li></ul> <ul><li><i><a href="/wiki/T_cell" title="T cell">T-lymphocyte</a></i> (<a href="/wiki/Zolimomab_aritox" title="Zolimomab aritox">Zolimomab aritox</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alemtuzumab" title="Alemtuzumab">Alemtuzumab</a></li> <li><a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Atorolimumab" title="Atorolimumab">Atorolimumab</a></li> <li><a href="/w/index.php?title=Begelomab&action=edit&redlink=1" class="new" title="Begelomab (page does not exist)">Begelomab</a></li> <li><a href="/wiki/Cedelizumab" title="Cedelizumab">Cedelizumab</a></li> <li><a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li> <li><a href="/wiki/Inebilizumab" title="Inebilizumab">Inebilizumab</a></li> <li><a href="/wiki/Maslimomab" title="Maslimomab">Maslimomab</a></li> <li><a href="/wiki/Morolimumab" title="Morolimumab">Morolimumab</a></li> <li><a href="/wiki/Ofatumumab" title="Ofatumumab">Ofatumumab</a></li> <li><a href="/wiki/Pexelizumab" title="Pexelizumab">Pexelizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li> <li><a href="/wiki/Rovelizumab" title="Rovelizumab">Rovelizumab</a></li> <li><a href="/wiki/Siplizumab" title="Siplizumab">Siplizumab</a></li> <li><a href="/wiki/Talizumab" title="Talizumab">Talizumab</a></li> <li><a href="/wiki/Telimomab_aritox" title="Telimomab aritox">Telimomab aritox</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/wiki/Vapaliximab" title="Vapaliximab">Vapaliximab</a></li> <li><a href="/wiki/Vepalimomab" title="Vepalimomab">Vepalimomab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polyclonal_antibodies" title="Polyclonal antibodies">Polyclonal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anti-thymocyte_globulin" title="Anti-thymocyte globulin">Anti-thymocyte globulin</a></li> <li><a href="/wiki/Anti-lymphocyte_globulin" title="Anti-lymphocyte globulin">Anti-lymphocyte globulin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">-cept (<a href="/wiki/Fusion_protein" title="Fusion protein">Fusion</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CTLA-4</a></i> <ul><li><a href="/wiki/Abatacept" title="Abatacept">Abatacept</a></li> <li><a href="/wiki/Belatacept" title="Belatacept">Belatacept</a></li></ul></li> <li><i><a href="/wiki/TNF_inhibitor" title="TNF inhibitor">TNF inhibitor</a></i> <ul><li><a href="/wiki/Etanercept" title="Etanercept">Etanercept</a></li> <li><a href="/w/index.php?title=Opinercept&action=edit&redlink=1" class="new" title="Opinercept (page does not exist)">Opinercept</a></li></ul></li> <li><a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li> <li><a href="/wiki/Alefacept" title="Alefacept">Alefacept</a></li> <li><a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Avacopan" title="Avacopan">Avacopan</a></li> <li><a class="mw-selflink selflink">Baricitinib</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a href="/wiki/Blisibimod" title="Blisibimod">Blisibimod</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Crovalimab" title="Crovalimab">Crovalimab</a></li> <li><a href="/wiki/Danicopan" title="Danicopan">Danicopan</a></li> <li><a href="/wiki/Darvadstrocel" title="Darvadstrocel">Darvadstrocel</a></li> <li><a href="/wiki/Deucravacitinib" title="Deucravacitinib">Deucravacitinib</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Dimethyl_fumarate" title="Dimethyl fumarate">Dimethyl fumarate</a></li> <li><a href="/wiki/Diroximel_fumarate" title="Diroximel fumarate">Diroximel fumarate</a></li> <li><a href="/wiki/Efgartigimod_alfa" title="Efgartigimod alfa">Efgartigimod alfa</a> (<a href="/wiki/Efgartigimod_alfa/hyaluronidase" title="Efgartigimod alfa/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Etrasimod" title="Etrasimod">Etrasimod</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Fingolimod" title="Fingolimod">Fingolimod</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Iptacopan" title="Iptacopan">Iptacopan</a></li> <li><a href="/w/index.php?title=Itacitinib&action=edit&redlink=1" class="new" title="Itacitinib (page does not exist)">Itacitinib</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/w/index.php?title=Netakimab&action=edit&redlink=1" class="new" title="Netakimab (page does not exist)">Netakimab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Ozanimod" title="Ozanimod">Ozanimod</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Pegcetacoplan" title="Pegcetacoplan">Pegcetacoplan</a></li> <li><a href="/wiki/Pirfenidone" title="Pirfenidone">Pirfenidone</a></li> <li><a href="/wiki/Ponesimod" title="Ponesimod">Ponesimod</a></li> <li><a href="/wiki/Ravulizumab" title="Ravulizumab">Ravulizumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Ritlecitinib" title="Ritlecitinib">Ritlecitinib</a></li> <li><a href="/wiki/Rozanolixizumab" title="Rozanolixizumab">Rozanolixizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Siponimod" title="Siponimod">Siponimod</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Sutimlimab" title="Sutimlimab">Sutimlimab</a></li> <li><a href="/wiki/Telitacicept" title="Telitacicept">Telitacicept</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib</a></li> <li><a href="/wiki/Upadacitinib" title="Upadacitinib">Upadacitinib</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cytokine_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cytokine_receptor_modulators" title="Template talk:Cytokine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cytokine_receptor_modulators" title="Special:EditPage/Template:Cytokine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Colony-stimulating_factor_receptor" class="mw-redirect" title="Colony-stimulating factor receptor">CSF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">Erythropoietin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=ARA-290&action=edit&redlink=1" class="new" title="ARA-290 (page does not exist)">ARA-290</a></li> <li><a href="/w/index.php?title=Asialo_erythropoietin&action=edit&redlink=1" class="new" title="Asialo erythropoietin (page does not exist)">Asialo erythropoietin</a></li> <li><a href="/w/index.php?title=Carbamylated_erythropoietin&action=edit&redlink=1" class="new" title="Carbamylated erythropoietin (page does not exist)">Carbamylated erythropoietin</a></li> <li><a href="/w/index.php?title=CNTO-530&action=edit&redlink=1" class="new" title="CNTO-530 (page does not exist)">CNTO-530</a></li> <li><a href="/wiki/Darbepoetin_alfa" title="Darbepoetin alfa">Darbepoetin alfa</a></li> <li><a href="/wiki/Epoetin_alfa" title="Epoetin alfa">Epoetin alfa</a></li> <li><a href="/wiki/Epoetin_beta" title="Epoetin beta">Epoetin beta</a></li> <li><a href="/w/index.php?title=Epoetin_delta&action=edit&redlink=1" class="new" title="Epoetin delta (page does not exist)">Epoetin delta</a></li> <li><a href="/w/index.php?title=Epoetin_epsilon&action=edit&redlink=1" class="new" title="Epoetin epsilon (page does not exist)">Epoetin epsilon</a></li> <li><a href="/w/index.php?title=Epoetin_gamma&action=edit&redlink=1" class="new" title="Epoetin gamma (page does not exist)">Epoetin gamma</a></li> <li><a href="/w/index.php?title=Epoetin_kappa&action=edit&redlink=1" class="new" title="Epoetin kappa (page does not exist)">Epoetin kappa</a></li> <li><a href="/w/index.php?title=Epoetin_omega&action=edit&redlink=1" class="new" title="Epoetin omega (page does not exist)">Epoetin omega</a></li> <li><a href="/wiki/Epoetin_theta" title="Epoetin theta">Epoetin theta</a></li> <li><a href="/wiki/Epoetin_zeta" class="mw-redirect" title="Epoetin zeta">Epoetin zeta</a></li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin (EPO)</a></li> <li><a href="/w/index.php?title=Erythropoietin-Fc&action=edit&redlink=1" class="new" title="Erythropoietin-Fc (page does not exist)">Erythropoietin-Fc</a></li> <li><a href="/wiki/Methoxy_polyethylene_glycol-epoetin_beta" title="Methoxy polyethylene glycol-epoetin beta">Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)</a></li> <li><a href="/wiki/Peginesatide" title="Peginesatide">Peginesatide</a></li> <li><a href="/w/index.php?title=Pegol_sihematide&action=edit&redlink=1" class="new" title="Pegol sihematide (page does not exist)">Pegol sihematide (EPO-018B)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF (CSF3)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Filgrastim" title="Filgrastim">Filgrastim</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor" title="Granulocyte colony-stimulating factor">Granulocyte colony-stimulating factor</a></li> <li><a href="/wiki/Lenograstim" title="Lenograstim">Lenograstim</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/wiki/Lipegfilgrastim" title="Lipegfilgrastim">Lipegfilgrastim</a></li> <li><a href="/w/index.php?title=Nartograstim&action=edit&redlink=1" class="new" title="Nartograstim (page does not exist)">Nartograstim</a></li> <li><a href="/wiki/Pegfilgrastim" title="Pegfilgrastim">Pegfilgrastim</a></li> <li><a href="/w/index.php?title=Pegnartograstim&action=edit&redlink=1" class="new" title="Pegnartograstim (page does not exist)">Pegnartograstim</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF (CSF2)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ecogramostim&action=edit&redlink=1" class="new" title="Ecogramostim (page does not exist)">Ecogramostim</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">Granulocyte macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/wiki/Molgramostim" title="Molgramostim">Molgramostim</a></li> <li><a href="/w/index.php?title=Regramostim&action=edit&redlink=1" class="new" title="Regramostim (page does not exist)">Regramostim</a></li> <li><a href="/wiki/Sargramostim" title="Sargramostim">Sargramostim</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Mavrilimumab" title="Mavrilimumab">Mavrilimumab</a></li> <li><a href="/wiki/Namilumab" title="Namilumab">Namilumab</a></li> <li><a href="/wiki/Otilimab" title="Otilimab">Otilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Macrophage colony-stimulating factor receptor">M-CSF (CSF1)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Cilmostim&action=edit&redlink=1" class="new" title="Cilmostim (page does not exist)">Cilmostim</a></li> <li><a href="/wiki/Interleukin-34" class="mw-redirect" title="Interleukin-34">Interleukin-34</a></li> <li><a href="/w/index.php?title=Lanimostim&action=edit&redlink=1" class="new" title="Lanimostim (page does not exist)">Lanimostim</a></li> <li><a href="/wiki/Macrophage_colony-stimulating_factor" title="Macrophage colony-stimulating factor">Macrophage colony-stimulating factor</a></li> <li><a href="/w/index.php?title=Mirimostim&action=edit&redlink=1" class="new" title="Mirimostim (page does not exist)">Mirimostim</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Eltrombopag" title="Eltrombopag">Eltrombopag</a></li> <li><a href="/w/index.php?title=Pegacaristim&action=edit&redlink=1" class="new" title="Pegacaristim (page does not exist)">Pegacaristim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li> <li><a href="/wiki/Romiplostim" title="Romiplostim">Romiplostim</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin (THPO, MGDF)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">IFNAR (α/β, I)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Albinterferon" title="Albinterferon">Albinterferon</a></li> <li><a href="/wiki/Interferon_alpha" class="mw-redirect" title="Interferon alpha">Interferon alpha (interferon alfa, IFN-α)</a></li> <li><a href="/wiki/Interferon_alfa" title="Interferon alfa">Interferon alfa</a> (<a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a>, <a href="/wiki/IFNA2" title="IFNA2">IFNA2</a>, <a href="/wiki/IFNA4" title="IFNA4">IFNA4</a>, <a href="/wiki/IFNA5" title="IFNA5">IFNA5</a>, <a href="/wiki/IFNA6" title="IFNA6">IFNA6</a>, <a href="/wiki/IFNA7" title="IFNA7">IFNA7</a>, <a href="/wiki/IFNA8" title="IFNA8">IFNA8</a>, <a href="/wiki/IFNA10" title="IFNA10">IFNA10</a>, <a href="/wiki/IFNA13" title="IFNA13">IFNA13</a>, <a href="/wiki/IFNA14" title="IFNA14">IFNA14</a>, <a href="/wiki/IFNA16" title="IFNA16">IFNA16</a>, <a href="/wiki/IFNA17" title="IFNA17">IFNA17</a>, <a href="/wiki/IFNA21" title="IFNA21">IFNA21</a>)</li> <li><a href="/wiki/Interferon_alfa_2a" class="mw-redirect" title="Interferon alfa 2a">Interferon alfa 2a</a></li> <li><a href="/wiki/Interferon_alfa_2b" class="mw-redirect" title="Interferon alfa 2b">Interferon alfa 2b</a></li> <li><a href="/w/index.php?title=Interferon_alfa_n1&action=edit&redlink=1" class="new" title="Interferon alfa n1 (page does not exist)">Interferon alfa n1</a></li> <li><a href="/wiki/Interferon_alfacon-1" title="Interferon alfacon-1">Interferon alfacon-1</a></li> <li><a href="/wiki/Interferon_alpha-n3" title="Interferon alpha-n3">Interferon alpha-n3</a></li> <li><a href="/wiki/Interferon_beta" class="mw-redirect" title="Interferon beta">Interferon beta (IFN-β)</a> (<a href="/wiki/IFNB1" title="IFNB1">IFNB1</a>, <a href="/w/index.php?title=IFNB3&action=edit&redlink=1" class="new" title="IFNB3 (page does not exist)">IFNB3</a>)</li> <li><a href="/wiki/Interferon_beta_1a" class="mw-redirect" title="Interferon beta 1a">Interferon beta 1a</a></li> <li><a href="/wiki/Interferon_beta_1b" class="mw-redirect" title="Interferon beta 1b">Interferon beta 1b</a></li> <li><a href="/wiki/Interferon_kappa" class="mw-redirect" title="Interferon kappa">Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)</a></li> <li><a href="/wiki/Interferon_omega" class="mw-redirect" title="Interferon omega">Interferon omega (IFN-ω, IFNW1)</a></li> <li><a href="/wiki/Peginterferon_alfa-2a" title="Peginterferon alfa-2a">Peginterferon alfa-2a</a></li> <li><a href="/wiki/Peginterferon_alfa-2b" title="Peginterferon alfa-2b">Peginterferon alfa-2b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li> <li><a href="/w/index.php?title=MEDI-545&action=edit&redlink=1" class="new" title="MEDI-545 (page does not exist)">MEDI-545</a></li> <li><a href="/wiki/Rontalizumab" title="Rontalizumab">Rontalizumab</a></li> <li><a href="/wiki/Sifalimumab" title="Sifalimumab">Sifalimumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=Bifarcept&action=edit&redlink=1" class="new" title="Bifarcept (page does not exist)">Bifarcept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">IFNGR (γ, II)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interferon_gamma" title="Interferon gamma">Interferon gamma (IFN-γ)</a></li> <li><a href="/wiki/Interferon_gamma_1b" class="mw-redirect" title="Interferon gamma 1b">Interferon gamma 1b</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interferon-lambda_receptor" class="mw-redirect" title="Interferon-lambda receptor">IFNLR (λ, III)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See IL-28R (IFNLR) <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TNF_receptor_superfamily_modulators" title="Template:TNF receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a><br /><small>(<a href="/wiki/Janus_kinase_inhibitor" title="Janus kinase inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK1" class="mw-redirect" title="JAK1">JAK1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abrocitinib" title="Abrocitinib">Abrocitinib</a></li> <li><a class="mw-selflink selflink">Baricitinib</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Filgotinib" title="Filgotinib">Filgotinib</a></li> <li><a href="/wiki/Momelotinib" title="Momelotinib">Momelotinib</a></li> <li><a href="/wiki/Oclacitinib" title="Oclacitinib">Oclacitinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/wiki/Upadacitinib" title="Upadacitinib">Upadacitinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK2" class="mw-redirect" title="JAK2">JAK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Atiprimod" title="Atiprimod">Atiprimod</a></li> <li><a href="/w/index.php?title=AZD-1480&action=edit&redlink=1" class="new" title="AZD-1480 (page does not exist)">AZD-1480</a></li> <li><a class="mw-selflink selflink">Baricitinib</a></li> <li><a href="/wiki/CHZ868" title="CHZ868">CHZ868</a></li> <li><a href="/wiki/Cucurbitacin_I" class="mw-redirect" title="Cucurbitacin I">Cucurbitacin I (elatericin B, JSI-124)</a></li> <li><a href="/wiki/CYT387" class="mw-redirect" title="CYT387">CYT387</a></li> <li><a href="/wiki/Deuruxolitinib" title="Deuruxolitinib">Deuruxolitinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=NSC-7908&action=edit&redlink=1" class="new" title="NSC-7908 (page does not exist)">NSC-7908</a></li> <li><a href="/w/index.php?title=NSC-33994&action=edit&redlink=1" class="new" title="NSC-33994 (page does not exist)">NSC-33994</a></li> <li><a href="/wiki/Pacritinib" title="Pacritinib">Pacritinib</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ruxolitinib" title="Ruxolitinib">Ruxolitinib</a></li> <li><a href="/w/index.php?title=SD-1008&action=edit&redlink=1" class="new" title="SD-1008 (page does not exist)">SD-1008</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/JAK3" class="mw-redirect" title="JAK3">JAK3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Cercosporamide&action=edit&redlink=1" class="new" title="Cercosporamide (page does not exist)">Cercosporamide</a></li> <li><a href="/wiki/Decernotinib" title="Decernotinib">Decernotinib (VX-509)</a></li> <li><a href="/wiki/Peficitinib" title="Peficitinib">Peficitinib</a></li> <li><a href="/wiki/Ritlecitinib" title="Ritlecitinib">Ritlecitinib</a></li> <li><a href="/w/index.php?title=TCS-21311&action=edit&redlink=1" class="new" title="TCS-21311 (page does not exist)">TCS-21311</a></li> <li><a href="/wiki/Tofacitinib" title="Tofacitinib">Tofacitinib (tasocitinib)</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li> <li><a href="/w/index.php?title=ZM-39923&action=edit&redlink=1" class="new" title="ZM-39923 (page does not exist)">ZM-39923</a></li> <li><a href="/w/index.php?title=ZM-449829&action=edit&redlink=1" class="new" title="ZM-449829 (page does not exist)">ZM-449829</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deucravacitinib" title="Deucravacitinib">Deucravacitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional cytokines:</i> <a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">Cardiotrophin 1 (CT-1)</a></li> <li><a href="/wiki/FMS-like_tyrosine_kinase_3_ligand" title="FMS-like tyrosine kinase 3 ligand">FMS-like tyrosine kinase 3 ligand (FLT3L)</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia/leukocyte inhibitory factor (LIF)</a></li> <li><a href="/wiki/Oncostatin_M" title="Oncostatin M">Oncostatin M (OSM)</a></li> <li><a href="/wiki/Thymic_stromal_lymphopoietin" title="Thymic stromal lymphopoietin">Thymic stromal lymphopoietin (TSLP)</a></li></ul> <ul><li><i>Additional cytokine receptor modulators:</i> <a href="/w/index.php?title=Emfilermin&action=edit&redlink=1" class="new" title="Emfilermin (page does not exist)">Emfilermin</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/wiki/Midostaurin" title="Midostaurin">Midostaurin</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Eli_Lilly_and_Company" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Eli_Lilly_and_Company" title="Template:Eli Lilly and Company"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Eli_Lilly_and_Company" title="Template talk:Eli Lilly and Company"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Eli_Lilly_and_Company" title="Special:EditPage/Template:Eli Lilly and Company"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Eli_Lilly_and_Company" style="font-size:114%;margin:0 4em"><a href="/wiki/Eli_Lilly_and_Company" title="Eli Lilly and Company">Eli Lilly and Company</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Corporation" title="Corporation">Corporate</a> <a href="/wiki/Board_of_directors" title="Board of directors">directors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/John_C._Lechleiter" title="John C. Lechleiter">John C. Lechleiter</a></li> <li><a href="/wiki/Ralph_Alvarez" title="Ralph Alvarez">Ralph Alvarez</a></li> <li><a href="/wiki/Winfried_Bischoff" title="Winfried Bischoff">Sir Winfried Bischoff</a></li> <li><a href="/wiki/Michael_L._Eskew" title="Michael L. Eskew">Michael L. Eskew</a></li> <li><a href="/wiki/Martin_Feldstein" title="Martin Feldstein">Martin S. Feldstein</a></li> <li><a href="/w/index.php?title=J._Erik_Fyrwald&action=edit&redlink=1" class="new" title="J. Erik Fyrwald (page does not exist)">J. Erik Fyrwald</a></li> <li><a href="/wiki/Alfred_G._Gilman" title="Alfred G. Gilman">Alfred G. Gilman</a></li> <li><a href="/wiki/Karen_N._Horn" title="Karen N. Horn">Karen N. Horn</a></li> <li><a href="/w/index.php?title=Ellen_R._Marram&action=edit&redlink=1" class="new" title="Ellen R. Marram (page does not exist)">Ellen R. Marram</a></li> <li><a href="/wiki/Douglas_R._Oberhelman" class="mw-redirect" title="Douglas R. Oberhelman">Douglas R. Oberhelman</a></li> <li><a href="/w/index.php?title=Franklyn_G._Prendergast&action=edit&redlink=1" class="new" title="Franklyn G. Prendergast (page does not exist)">Franklyn G. Prendergast</a></li> <li><a href="/wiki/Kathi_Seifert" title="Kathi Seifert">Kathi P. Seifert</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Products</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adcirca" class="mw-redirect" title="Adcirca">Adcirca</a></li> <li><a href="/wiki/Pemetrexed" title="Pemetrexed">Alimta</a></li> <li><a href="/wiki/Amyvid" class="mw-redirect" title="Amyvid">Amyvid</a></li> <li><a href="/wiki/Bamlanivimab" title="Bamlanivimab">Bamlanivimab</a></li> <li><a href="/wiki/Baqsimi" class="mw-redirect" title="Baqsimi">Baqsimi</a></li> <li><a class="mw-selflink selflink">Baricitinib</a></li> <li><a href="/wiki/Basaglar" class="mw-redirect" title="Basaglar">Basaglar</a></li> <li><a href="/wiki/Tadalafil" title="Tadalafil">Cialis</a></li> <li><a href="/wiki/Duloxetine" title="Duloxetine">Cymbalta</a></li> <li><a href="/wiki/Cyramza" class="mw-redirect" title="Cyramza">Cyramza</a></li> <li><a href="/wiki/Emgality" class="mw-redirect" title="Emgality">Emgality</a></li> <li><a href="/wiki/Erbitux" class="mw-redirect" title="Erbitux">Erbitux</a></li> <li><a href="/wiki/Etesevimab" class="mw-redirect" title="Etesevimab">Etesevimab</a></li> <li><a href="/wiki/Raloxifene" title="Raloxifene">Evista</a></li> <li><a href="/wiki/Teriparatide" title="Teriparatide">Forteo</a></li> <li><a href="/wiki/Gemcitabine" title="Gemcitabine">Gemzar</a></li> <li><a href="/wiki/Glucagon_(medication)" title="Glucagon (medication)">Glucagon</a></li> <li><a href="/wiki/Glyxambi" class="mw-redirect" title="Glyxambi">Glyxambi</a></li> <li><a href="/wiki/Insulin_lispro" title="Insulin lispro">Humalog</a></li> <li><a href="/wiki/Humatrope" class="mw-redirect" title="Humatrope">Humatrope</a></li> <li><a href="/wiki/Humulin" class="mw-redirect" title="Humulin">Humulin</a></li> <li><a href="/wiki/Jardiance" class="mw-redirect" title="Jardiance">Jardiance</a></li> <li><a href="/wiki/Jaypirca" class="mw-redirect" 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