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class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=PAS+domain" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=PAS+domain" title="You're encouraged to log in; however, it's not mandatory. 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[o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Discovery" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Discovery"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Discovery</span> </div> </a> <ul id="toc-Discovery-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Structure</span> </div> </a> <ul id="toc-Structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Examples_of_PAS_in_organisms" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Examples_of_PAS_in_organisms"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Examples of PAS in organisms</span> </div> </a> <button aria-controls="toc-Examples_of_PAS_in_organisms-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Examples of PAS in organisms subsection</span> </button> <ul id="toc-Examples_of_PAS_in_organisms-sublist" class="vector-toc-list"> <li id="toc-Bacteria" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bacteria"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Bacteria</span> </div> </a> <ul id="toc-Bacteria-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Neurospora" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Neurospora"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span><i>Neurospora</i></span> </div> </a> <ul id="toc-Neurospora-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Drosophila" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drosophila"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span><i>Drosophila</i></span> </div> </a> <ul id="toc-Drosophila-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Arabidopsis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Arabidopsis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.4</span> <span><i>Arabidopsis</i></span> </div> </a> <ul id="toc-Arabidopsis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mammals" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mammals"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.5</span> <span>Mammals</span> </div> </a> <ul id="toc-Mammals-sublist" class="vector-toc-list"> <li id="toc-Other_mammalian_PAS_roles" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Other_mammalian_PAS_roles"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.5.1</span> <span>Other mammalian PAS roles</span> </div> </a> <ul id="toc-Other_mammalian_PAS_roles-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Related_sensor_domains" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Related_sensor_domains"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Related sensor domains</span> </div> </a> <button aria-controls="toc-Related_sensor_domains-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Related sensor domains subsection</span> </button> <ul id="toc-Related_sensor_domains-sublist" class="vector-toc-list"> <li id="toc-GAF_domain" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#GAF_domain"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>GAF domain</span> </div> </a> <ul id="toc-GAF_domain-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cache_domain" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cache_domain"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Cache domain</span> </div> </a> <ul id="toc-Cache_domain-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Other_sensor_domains" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Other_sensor_domains"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Other sensor domains</span> </div> </a> <button aria-controls="toc-Other_sensor_domains-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Other sensor domains subsection</span> </button> <ul id="toc-Other_sensor_domains-sublist" class="vector-toc-list"> <li id="toc-Hpt_domain" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hpt_domain"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Hpt domain</span> </div> </a> <ul id="toc-Hpt_domain-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-HAMP_domain" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#HAMP_domain"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>HAMP domain</span> </div> </a> <ul id="toc-HAMP_domain-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">PAS domain</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in 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Available in 5 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Dominio_PAS" title="Dominio PAS – Spanish" lang="es" hreflang="es" data-title="Dominio PAS" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Domaine_PAS" title="Domaine PAS – French" lang="fr" hreflang="fr" data-title="Domaine PAS" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/PAS_domen" title="PAS domen – Serbian" lang="sr" hreflang="sr" data-title="PAS domen" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/PAS_domen" title="PAS domen – Serbo-Croatian" lang="sh" hreflang="sh" data-title="PAS domen" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/PAS%E7%BB%93%E6%9E%84%E5%9F%9F" title="PAS结构域 – Chinese" lang="zh" hreflang="zh" data-title="PAS结构域" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q36626#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/PAS_domain" title="View the content page 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class="mw-list-item"><a href="/w/index.php?title=Special:QrCode&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FPAS_domain"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=PAS_domain&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=PAS_domain&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div 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data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein domain</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">PAS fold</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:FixL_1y28.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/FixL_1y28.png/220px-FixL_1y28.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/FixL_1y28.png/330px-FixL_1y28.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9b/FixL_1y28.png/440px-FixL_1y28.png 2x" data-file-width="1440" data-file-height="1080" /></a></span><div class="infobox-caption">Crystallographic structure of the PAS domain of the bacterial oxygen sensor protein fixL.<sup id="cite_ref-pmid12820879_1-0" class="reference"><a href="#cite_note-pmid12820879-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> The protein is depicted as a rainbow colored cartoon (<a href="/wiki/N-terminus" title="N-terminus">N-terminus</a> = blue, <a href="/wiki/C-terminus" title="C-terminus">C-terminus</a> = red) while the <a href="/wiki/Heme" title="Heme">heme</a> ligand is shown as sticks (carbon = white, nitrogen = blue, oxygen = red, iron = orange).</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">PAS</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF00989">PF00989</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a> clan</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/set/pfam/CL0183/">CL0183</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ECOD" class="mw-redirect" title="ECOD">ECOD</a></th><td class="infobox-data ECOD" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/tree?id=223.1.1">223.1.1</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR013767">IPR013767</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Simple_Modular_Architecture_Research_Tool" title="Simple Modular Architecture Research Tool">SMART</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=PAS">PAS</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PROSITE" title="PROSITE">PROSITE</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://prosite.expasy.org/PDOC50112">PDOC50112</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Structural_Classification_of_Proteins" class="mw-redirect" title="Structural Classification of Proteins">SCOP2</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://scop2.mrc-lmb.cam.ac.uk/search?t=txt;q=2phy">2phy</a> / <a rel="nofollow" class="external text" href="https://scop.berkeley.edu/pdb/code=2phy">SCOPe</a> / <a rel="nofollow" class="external text" href="http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=2phy">SUPFAM</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Conserved_Domain_Database" title="Conserved Domain Database">CDD</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130">cd00130</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF00989?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF00989">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF00989%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF00989">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF00989">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF00989">structure summary</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1byw">1byw</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1d06">1d06</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1d7e">1d7e</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1dp6">1dp6</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1dp8">1dp8</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1dp9">1dp9</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1drm">1drm</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ew0">1ew0</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1f98">1f98</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1f9i">1f9i</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1gsv">1gsv</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1gsw">1gsw</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1gsx">1gsx</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1kou">1kou</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ll8">1ll8</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1lsv">1lsv</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1lsw">1lsw</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1lsx">1lsx</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1lt0">1lt0</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1mzu">1mzu</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1nwz">1nwz</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1odv">1odv</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ot6">1ot6</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ot9">1ot9</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ota">1ota</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1otb">1otb</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1otd">1otd</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ote">1ote</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1oti">1oti</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s1y">1s1y</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s1z">1s1z</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s4r">1s4r</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s4s">1s4s</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s66">1s66</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1s67">1s67</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1t18">1t18</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1t19">1t19</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1t1a">1t1a</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1t1b">1t1b</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1t1c">1t1c</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ts0">1ts0</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ts6">1ts6</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ts7">1ts7</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ts8">1ts8</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ugu">1ugu</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1uwn">1uwn</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1uwp">1uwp</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1v9y">1v9y</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1v9z">1v9z</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1vb6">1vb6</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1wa9">1wa9</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xfn">1xfn</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xfq">1xfq</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xj2">1xj2</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xj3">1xj3</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xj4">1xj4</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1xj6">1xj6</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1y28">1y28</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2d01">2d01</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2d02">2d02</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2phy">2phy</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2pyp">2pyp</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2pyr">2pyr</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3phy">3phy</a></span>, <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3pyp">3pyp</a></span></td></tr></tbody></table></td></tr></tbody></table> <p>A <b>Per-Arnt-Sim</b> (<b>PAS</b>) <b>domain</b> is a <a href="/wiki/Protein_domain" title="Protein domain">protein domain</a> found in all kingdoms of life.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Generally, the PAS domain acts as a molecular sensor, whereby small molecules and other proteins associate via binding of the PAS domain.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-katja_5-0" class="reference"><a href="#cite_note-katja-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Due to this sensing capability, the PAS domain has been shown as the key <a href="/wiki/Structural_motif" title="Structural motif">structural motif</a> involved in protein-protein interactions of the <a href="/wiki/Circadian_clock" title="Circadian clock">circadian clock</a>, and it is also a common motif found in signaling proteins, where it functions as a signaling sensor.<sup id="cite_ref-pmid9382818_6-0" class="reference"><a href="#cite_note-pmid9382818-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid15009198_7-0" class="reference"><a href="#cite_note-pmid15009198-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Discovery">Discovery</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=1" title="Edit section: Discovery"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PAS domains are found in a large number of organisms from bacteria to mammals. The PAS domain was named after the three proteins in which it was first discovered:<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Per – <a href="/wiki/Period_(gene)" title="Period (gene)">period circadian protein</a></li> <li>Arnt – <a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">aryl hydrocarbon receptor nuclear translocator protein</a></li> <li>Sim – <a href="/wiki/SIM1" title="SIM1">single-minded protein</a></li></ul> <p>Since the initial discovery of the PAS domain, a large quantity of PAS domain binding sites have been discovered in bacteria and eukaryotes. A subset called <a href="/wiki/Light-oxygen-voltage-sensing_domain" title="Light-oxygen-voltage-sensing domain">PAS LOV</a> proteins are responsive to oxygen, light and voltage.<sup id="cite_ref-love_9-0" class="reference"><a href="#cite_note-love-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Although the PAS domain exhibits a degree of sequence variability, the three-dimensional structure of the PAS domain core is broadly conserved.<sup id="cite_ref-henry_10-0" class="reference"><a href="#cite_note-henry-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> This core consists of a five-stranded antiparallel β-sheet and several α-helices. Structural changes, as a result of signaling, predominantly originate within the <a href="/wiki/Beta_sheet" title="Beta sheet">β-sheet</a>. These signals propagate via the <a href="/wiki/Alpha_helix" title="Alpha helix">α-helices</a> of the core to the covalently-attached effector domain.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> In 1998, the PAS domain core architecture was first characterized in the structure of <a href="/wiki/Photoactive_yellow_protein" title="Photoactive yellow protein">photoactive yellow protein</a> (PYP) from <i><a href="/wiki/Halorhodospira_halophila" title="Halorhodospira halophila">Halorhodospira halophila</a></i>.<sup id="cite_ref-henry_10-1" class="reference"><a href="#cite_note-henry-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> In many proteins, a dimer of PAS domains is required, whereby one binds a ligand and the other mediates interactions with other proteins.<sup id="cite_ref-katja_5-1" class="reference"><a href="#cite_note-katja-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Examples_of_PAS_in_organisms">Examples of PAS in organisms</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=3" title="Edit section: Examples of PAS in organisms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The PAS domains that are known share less than 20% average <a href="/wiki/Sequence_alignment" title="Sequence alignment">pairwise sequence</a> identity, meaning they are surprisingly dissimilar.<sup id="cite_ref-henry_10-2" class="reference"><a href="#cite_note-henry-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> PAS domains are frequently found on proteins with other environmental sensing mechanisms. Also, many PAS domains are attached to photoreceptive cells.<sup id="cite_ref-mc_12-0" class="reference"><a href="#cite_note-mc-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Bacteria">Bacteria</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=4" title="Edit section: Bacteria"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Often in the bacterial kingdom, PAS domains are positioned at the amino terminus of signaling proteins such as sensor <a href="/wiki/Histidine_kinase" title="Histidine kinase">histidine kinases</a>, <a href="/wiki/Cyclic_di-GMP" title="Cyclic di-GMP">cyclic-di-GMP syntheses</a> and hydrolases, and <a href="/wiki/Methyl-accepting_chemotaxis_protein" class="mw-redirect" title="Methyl-accepting chemotaxis protein">methyl-accepting chemotaxis proteins</a>.<sup id="cite_ref-henry_10-3" class="reference"><a href="#cite_note-henry-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Neurospora"><i>Neurospora</i></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=5" title="Edit section: Neurospora"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Neurospora" title="Neurospora">Neurospora</a></div> <p>In the presence of light, <a href="/wiki/White_Collar-1" title="White Collar-1">White Collar-1</a> (WC-1) and White Collar-2 (WC-2) dimerizes via mediation by the PAS domains, which activates translation of <a href="/wiki/Frequency_(gene)" title="Frequency (gene)">FRQ</a>.<sup id="cite_ref-mol_13-0" class="reference"><a href="#cite_note-mol-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Drosophila"><i>Drosophila</i></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=6" title="Edit section: Drosophila"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Drosophila" title="Drosophila">Drosophila</a></div> <p>In the presence of light, <a href="/wiki/CLOCK" title="CLOCK">CLK</a> and <a href="/wiki/Cycle_(gene)" title="Cycle (gene)">CYC</a> attach via a PAS domain, activating the translation of PER, which then associates to <a href="/wiki/Timeless_(gene)" title="Timeless (gene)">Tim</a> via the PER PAS domain. The following genes contain PAS binding domains: PER, Tim, CLK, CYC. </p> <div class="mw-heading mw-heading3"><h3 id="Arabidopsis"><i>Arabidopsis</i></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=7" title="Edit section: Arabidopsis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Arabidopsis" title="Arabidopsis">Arabidopsis</a></div> <p>A PAS domain is found in the ZTL and NPH1 genes. These domains are very similar to the PAS domain found in the <i>Neurospora</i> circadian-associated protein WC-1.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mammals">Mammals</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=8" title="Edit section: Mammals"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The circadian clock that is currently understood for mammals begins when light activates <a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">BMAL1</a> and <a href="/wiki/CLOCK" title="CLOCK">CLK</a> to bind via their PAS domains. That activator complex regulates Per1, Per2, and Per3 which all have PAS domains that are used to bind to cryptochromes 1 and 2 (<a href="/wiki/Cryptochrome" title="Cryptochrome">CRY 1,2</a> family). The following mammalian genes contain PAS binding domains: Per1, Per2, Per3, Cry1, Cry2, Bmal, Clk, Pasd1. </p> <div class="mw-heading mw-heading4"><h4 id="Other_mammalian_PAS_roles">Other mammalian PAS roles</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=9" title="Edit section: Other mammalian PAS roles"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Within Mammals, both PAS domains play important roles. PAS A is responsible for the protein-protein interactions with other PAS domain proteins, while PAS B has a more versatile role. It mediates interactions with <a href="/wiki/Chaperonin" title="Chaperonin">chaperonins</a> and other small molecules like <a href="/wiki/Dioxins_and_dioxin-like_compounds" title="Dioxins and dioxin-like compounds">dioxin</a>, but PAS B domains in <a href="/wiki/NPAS2" title="NPAS2">NPAS2</a>, a homolog of the Drosophila clk gene, and the <a href="/wiki/Hypoxia-inducible_factors" class="mw-redirect" title="Hypoxia-inducible factors">hypoxia inducible factor</a> (HIF) also help to mediate <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> binding.<sup id="cite_ref-mc_12-1" class="reference"><a href="#cite_note-mc-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Furthermore, PAS domains containing the NPAS2 protein have been shown to be a substitute for the Clock gene in mutant mice who lack the Clock gene completely.<sup id="cite_ref-pmid16675400_15-0" class="reference"><a href="#cite_note-pmid16675400-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>The PAS domain also directly interacts with <a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">BHLH</a>. It is typically located on the <a href="/wiki/C-terminus" title="C-terminus">C-Terminus</a> of the BHLH protein. PAS domains containing BHLH proteins form a BHLH-Pas protein, typically found and encoded in HIF, which require both the PAS domain and BHLH domain and the Clock gene.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Related_sensor_domains">Related sensor domains</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=10" title="Edit section: Related sensor domains"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="GAF_domain">GAF domain</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=11" title="Edit section: GAF domain"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">GAF domain</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">GAF</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a> clan</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/set/pfam/CL0161/">CL0161</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ECOD" class="mw-redirect" title="ECOD">ECOD</a></th><td class="infobox-data ECOD" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/tree?id=223.1.1">223.1.1</a></td></tr></tbody></table> <p>These cGMP-binding domains are found in diverse phototransducing proteins across <a href="/wiki/Eukaryote" title="Eukaryote">eukaryotes</a> and <a href="/wiki/Bacteria" title="Bacteria">eubacteria</a>. They are present in plant and cyanobacterial <a href="/wiki/Phytochrome" title="Phytochrome">phytochromes</a>, vertebrate and invertebrate cGMP-stimulated <a href="/wiki/Phosphodiesterase" title="Phosphodiesterase">phosphodiesterases</a> (PDEs) and some non-photosynthetic eubacteria.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Galperin_2001_20-0" class="reference"><a href="#cite_note-Galperin_2001-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cache_domain">Cache domain</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=12" title="Edit section: Cache domain"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Cache domain</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Cache</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a> clan</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/set/pfam/CL0165/">CL0165</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ECOD" class="mw-redirect" title="ECOD">ECOD</a></th><td class="infobox-data ECOD" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/tree?id=223.1.1">223.1.1</a></td></tr></tbody></table> <p>These extracellular signaling domains are homologous to PAS domains but distinct.<sup id="cite_ref-Upadhyay_2016_22-0" class="reference"><a href="#cite_note-Upadhyay_2016-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> They are common to animal <a href="/wiki/Calcium_channel" title="Calcium channel">calcium (Ca2+) channel</a> subunits and certain <a href="/wiki/Prokaryote" title="Prokaryote">prokaryotic</a> <a href="/wiki/Chemotaxis" title="Chemotaxis">chemotaxis</a> receptors and play a role in small-molecule recognition across various species, suggesting a conserved mechanism of ligand binding.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> As opposite to the intracellular PAS and GAF domains, they show a long extra N-terminal <a href="/wiki/Alpha_helix" title="Alpha helix">alpha helix</a>.<sup id="cite_ref-Upadhyay_2016_22-1" class="reference"><a href="#cite_note-Upadhyay_2016-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Other_sensor_domains">Other sensor domains</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=13" title="Edit section: Other sensor domains"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Hpt_domain">Hpt domain</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=14" title="Edit section: Hpt domain"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Hpt domain</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Hpt</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF01627">PF01627</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ECOD" class="mw-redirect" title="ECOD">ECOD</a></th><td class="infobox-data ECOD" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/tree?id=601.3.1">601.3.1</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR036641">IPR036641</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF01627?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF01627">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF01627%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF01627">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF01627">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF01627">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p>Also known as <a href="/wiki/Histidine_phosphotransfer_domain" title="Histidine phosphotransfer domain">histidine phosphotransfer domains</a> and histidine phosphotransferases, these domains are <a href="/wiki/Protein_domain" title="Protein domain">protein domains</a> involved in the "phosphorelay" form of <a href="/wiki/Two-component_regulatory_system" title="Two-component regulatory system">two-component regulatory systems</a>. <sup id="cite_ref-Galperin_2001_20-1" class="reference"><a href="#cite_note-Galperin_2001-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="HAMP_domain">HAMP domain</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=15" title="Edit section: HAMP domain"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">HAMP</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">HAMP</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF00672">PF00672</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Pfam" title="Pfam">Pfam</a> clan</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/set/pfam/CL0681/">CL0681</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ECOD" class="mw-redirect" title="ECOD">ECOD</a></th><td class="infobox-data ECOD" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/tree?id=4168.1.1">4168.1.1</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR003660">IPR003660</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF00672?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF00672">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF00672%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF00672">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF00672">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF00672">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <p>The <b>HAMP domain</b> (present in <a href="/wiki/Histidine_kinase" title="Histidine kinase">Histidine kinases</a>, <a href="/wiki/Adenylate_cyclase" class="mw-redirect" title="Adenylate cyclase">Adenylate cyclases</a>, <a href="/wiki/Methyl-accepting_chemotaxis_protein" class="mw-redirect" title="Methyl-accepting chemotaxis protein">Methyl accepting proteins</a> and <a href="/wiki/Phosphatase" title="Phosphatase">Phosphatases</a>)<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> is an approximately 50-amino acid <a href="/wiki/Alpha_helix" title="Alpha helix">alpha-helical</a> region that forms a dimeric, four-helical <a href="/wiki/Coiled_coil" title="Coiled coil">coiled coil</a>.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PAS_domain&action=edit&section=16" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol 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no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output 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.navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Protein_domains" title="Template:Protein domains"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Protein_domains" title="Template talk:Protein domains"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Protein_domains" title="Special:EditPage/Template:Protein domains"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein_domains" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein_domain" title="Protein domain">Protein domains</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3H_domain" title="3H domain">3H</a></li> <li><a href="/wiki/ABM_domain" title="ABM domain">ABM</a></li> <li><a href="/wiki/ACDC_domain" title="ACDC domain">ACDC</a></li> <li><a href="/wiki/ACT_domain" title="ACT domain">ACT</a></li> <li><a href="/wiki/ADF-H_domain" title="ADF-H domain">ADF-H</a></li> <li><a href="/wiki/ANTH_domain" title="ANTH domain">ANTH</a></li> <li><a href="/wiki/ARID_domain" title="ARID domain">ARID</a></li> <li><a href="/wiki/BAR_domain" title="BAR domain">BAR</a></li> <li><a href="/wiki/BEN_domain" title="BEN domain">BEN</a></li> <li><a href="/wiki/BESS_domain" title="BESS domain">BESS</a></li> <li><a href="/wiki/Inhibitor_of_apoptosis_domain" title="Inhibitor of apoptosis domain">BIR</a></li> <li><a href="/wiki/BMC_domain" title="BMC domain">BMC</a></li> <li><a href="/wiki/BPS_domain" title="BPS domain">BPS</a></li> <li><a href="/wiki/BTB/POZ_domain" title="BTB/POZ domain">BTB/POZ</a></li> <li><a href="/wiki/BZIP_domain" title="BZIP domain">BZIP</a></li> <li><a href="/wiki/C1_domain" title="C1 domain">C1</a></li> <li><a href="/wiki/C2_domain" title="C2 domain">C2</a></li> <li><a href="/wiki/Cache_domain" title="Cache domain">Cache</a></li> <li><a href="/wiki/CBS_domain" title="CBS domain">CBS</a></li> <li><a href="/wiki/Kinase_binding_protein_CGI-121" title="Kinase binding protein CGI-121">CGI-121</a></li> <li><a href="/wiki/CRM_domain" title="CRM domain">CRM</a></li> <li><a href="/wiki/CUB_domain" title="CUB domain">CUB</a></li> <li><a href="/wiki/CUT_domain" title="CUT domain">CUT</a></li> <li><a href="/wiki/CVNH_domain" title="CVNH domain">CVHN</a></li> <li><a href="/wiki/Death_fold" title="Death fold">Death</a> <ul><li><a href="/wiki/Death_domain" title="Death domain">DD</a></li> <li><a href="/wiki/Death_effector_domain" title="Death effector domain">DED</a></li> <li><a href="/wiki/CARD_(domain)" title="CARD (domain)">CARD</a></li> <li><a href="/wiki/Pyrin_domain" title="Pyrin domain">Pyrin</a></li></ul></li> <li><a href="/wiki/DEP_domain" title="DEP domain">DEP</a></li> <li><a href="/wiki/DHHC_domain" title="DHHC domain">DHHC</a></li> <li><a href="/wiki/DHR1_domain" title="DHR1 domain">DHR1</a></li> <li><a href="/wiki/DHR2_domain" title="DHR2 domain">DHR2</a></li> <li><a href="/wiki/DM_domain" title="DM domain">DM</a></li> <li><a href="/wiki/EcoEI_R_protein_C-terminal_domain" title="EcoEI R protein C-terminal domain">EcoEI_R_C</a></li> <li><a href="/wiki/EF1_guanine_nucleotide_exchange_domain" title="EF1 guanine nucleotide exchange domain">EF1</a></li> <li><a href="/wiki/ENTH_domain" title="ENTH domain">ENTH</a></li> <li><a href="/wiki/FGGY_carbohydrate_kinase_family" title="FGGY carbohydrate kinase family">FGGY</a></li> <li><a href="/wiki/FYVE_domain" title="FYVE domain">FYVE</a></li> <li><a href="/wiki/HEAT_repeat_domain" class="mw-redirect" title="HEAT repeat domain">HEAT</a></li> <li><a href="/wiki/Kringle_domain" title="Kringle domain">Kringle</a></li> <li><a href="/wiki/LIM_domain" title="LIM domain">LIM</a></li> <li><a href="/wiki/Leucine-rich_repeat" title="Leucine-rich repeat">LRR</a></li> <li><a href="/wiki/NACHT_domain" title="NACHT domain">NACHT</a></li> <li><a class="mw-selflink selflink">PAS</a> <ul><li><a href="/wiki/Light-oxygen-voltage-sensing_domain" title="Light-oxygen-voltage-sensing domain">LOV</a></li></ul></li> <li><a href="/wiki/PDZ_domain" title="PDZ domain">PDZ</a></li> <li><a href="/wiki/Pleckstrin_homology_domain" title="Pleckstrin homology domain">PH</a></li> <li><a href="/wiki/PX_domain" title="PX domain">PX</a></li> <li><a href="/wiki/SH2_domain" title="SH2 domain">SH2</a></li> <li><a href="/wiki/SH3_domain" title="SH3 domain">SH3</a></li> <li><a href="/wiki/SUN_domain" title="SUN domain">SUN</a></li> <li><a href="/wiki/CRAL-TRIO_domain" title="CRAL-TRIO domain">TRIO</a></li> <li><a href="/wiki/WD40_repeat" title="WD40 repeat">WD40</a></li> <li><a href="/wiki/X8_protein_domain" title="X8 protein domain">X8</a></li> <li><a href="/wiki/YTH_protein_domain" title="YTH protein domain">YTH</a></li> <li><a href="/wiki/Zinc_finger" title="Zinc finger">zinc finger</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=PAS_domain&oldid=1249492576">https://en.wikipedia.org/w/index.php?title=PAS_domain&oldid=1249492576</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:PAS_domain" title="Category:PAS domain">PAS domain</a></li><li><a href="/wiki/Category:Protein_superfamilies" title="Category:Protein superfamilies">Protein superfamilies</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden 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