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id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein domain</div> <p><b>DHR2</b> (<u>D</u>OCK <u>h</u>omology <u>r</u>egion 2), also known as <b>CZH2</b> or <b>Docker2</b>, is a <a href="/wiki/Protein_domain" title="Protein domain">protein domain</a> of approximately 450-550 <a href="/wiki/Amino_acids" class="mw-redirect" title="Amino acids">amino acids</a> that is present in the <a href="/wiki/DOCK_(protein)" title="DOCK (protein)">DOCK</a> family of proteins.<sup id="cite_ref-Meller_2005_1-0" class="reference"><a href="#cite_note-Meller_2005-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> This domain functions as a <a href="/wiki/Guanine_nucleotide_exchange_factor" title="Guanine nucleotide exchange factor">guanine nucleotide exchange factor</a> (GEF) domain for small <a href="/wiki/G_protein" title="G protein">G proteins</a> of the <a href="/wiki/Rho_family" class="mw-redirect" title="Rho family">Rho family</a>.<sup id="cite_ref-Côté_2002_2-0" class="reference"><a href="#cite_note-Côté_2002-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> DHR2 domains bear no significant similarity to the well described <a href="/wiki/RhoGEF_domain" title="RhoGEF domain">DH domain</a> (<u>D</u>bl <u>h</u>omologous domain) present in other RhoGEFs such as <a href="/wiki/Vav_(protein)" title="Vav (protein)">Vav</a>, <a href="/w/index.php?title=P-Rex&action=edit&redlink=1" class="new" title="P-Rex (page does not exist)">P-Rex</a> and <a href="/wiki/TRIO_(gene)" title="TRIO (gene)">TRIO</a>. Indeed, the most divergent mammalian DHR2 domains share only 16-17% <a href="/wiki/Sequence_similarity" class="mw-redirect" title="Sequence similarity">sequence similarity</a>. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DHR2_domain&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Meller_2005-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Meller_2005_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFMellerMerlotGuda2005" class="citation journal cs1">Meller N, Merlot S, Guda C (November 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.02671">"CZH proteins: a new family of Rho-GEFs"</a>. <i>J. Cell Sci</i>. <b>118</b> (Pt 21): 4937–46. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.02671">10.1242/jcs.02671</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16254241">16254241</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Sci.&rft.atitle=CZH+proteins%3A+a+new+family+of+Rho-GEFs&rft.volume=118&rft.issue=Pt+21&rft.pages=4937-46&rft.date=2005-11&rft_id=info%3Adoi%2F10.1242%2Fjcs.02671&rft_id=info%3Apmid%2F16254241&rft.aulast=Meller&rft.aufirst=N&rft.au=Merlot%2C+S&rft.au=Guda%2C+C&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fjcs.02671&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADHR2+domain" class="Z3988"></span></span> </li> <li id="cite_note-Côté_2002-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-Côté_2002_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCôtéVuori2002" class="citation journal cs1">Côté JF, Vuori K (December 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.00219">"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity"</a>. <i>J. Cell Sci</i>. <b>115</b> (Pt 24): 4901–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.00219">10.1242/jcs.00219</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12432077">12432077</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Cell+Sci.&rft.atitle=Identification+of+an+evolutionarily+conserved+superfamily+of+DOCK180-related+proteins+with+guanine+nucleotide+exchange+activity&rft.volume=115&rft.issue=Pt+24&rft.pages=4901-13&rft.date=2002-12&rft_id=info%3Adoi%2F10.1242%2Fjcs.00219&rft_id=info%3Apmid%2F12432077&rft.aulast=C%C3%B4t%C3%A9&rft.aufirst=JF&rft.au=Vuori%2C+K&rft_id=https%3A%2F%2Fdoi.org%2F10.1242%252Fjcs.00219&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADHR2+domain" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DHR2_domain&action=edit&section=2" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCôtéVuori2007" class="citation journal cs1">Côté JF, Vuori K (2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887429">"GEF what? Dock180 and related proteins help Rac to polarize cells in new ways"</a>. <i>Trends Cell Biol</i>. <b>17</b> (8): 383–393. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.tcb.2007.05.001">10.1016/j.tcb.2007.05.001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887429">2887429</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17765544">17765544</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Trends+Cell+Biol.&rft.atitle=GEF+what%3F+Dock180+and+related+proteins+help+Rac+to+polarize+cells+in+new+ways&rft.volume=17&rft.issue=8&rft.pages=383-393&rft.date=2007&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2887429%23id-name%3DPMC&rft_id=info%3Apmid%2F17765544&rft_id=info%3Adoi%2F10.1016%2Fj.tcb.2007.05.001&rft.aulast=C%C3%B4t%C3%A9&rft.aufirst=JF&rft.au=Vuori%2C+K&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2887429&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADHR2+domain" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCôtéVuori2006" class="citation book cs1">Côté JF, Vuori K (2006). "In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains". <i>Regulators and Effectors of Small GTPases: Rho Family</i>. Methods in Enzymology. 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