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class="vector-toc-numb">2</span> <span>Signal transduction</span> </div> </a> <ul id="toc-Signal_transduction-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Clinical significance</span> </div> </a> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cardiovascular_implications" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Cardiovascular_implications"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Cardiovascular implications</span> </div> </a> <ul id="toc-Cardiovascular_implications-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacology" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacology"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Pharmacology</span> </div> </a> <ul id="toc-Pharmacology-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CXCR3</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" 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Available in 7 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-7" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">7 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/CXCR3" title="CXCR3 – German" lang="de" hreflang="de" data-title="CXCR3" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/CXCR3" title="CXCR3 – French" lang="fr" hreflang="fr" data-title="CXCR3" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/CXCR3" title="CXCR3 – Korean" lang="ko" hreflang="ko" data-title="CXCR3" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/CXCR3" title="CXCR3 – Japanese" lang="ja" hreflang="ja" data-title="CXCR3" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/CXCR3" title="CXCR3 – Russian" lang="ru" hreflang="ru" data-title="CXCR3" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/CXCR3" title="CXCR3 – Ukrainian" lang="uk" hreflang="uk" data-title="CXCR3" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/CXCR3" title="CXCR3 – Chinese" lang="zh" hreflang="zh" data-title="CXCR3" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q655541#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> 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</div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in humans</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">CXCR3</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/4540">CXCR3</a></span>, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C motif chemokine receptor 3, CD182</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/300574">300574</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1277207">1277207</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1153">1153</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CXCR3">CXCR3</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000186810">CXCR3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_X.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/300px-Ideogram_human_chromosome_X.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/450px-Ideogram_human_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/600px-Ideogram_human_chromosome_X.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/X_chromosome_(human)" class="mw-redirect" title="X chromosome (human)">X chromosome (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_X_ideogram.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/300px-Human_chromosome_X_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/450px-Human_chromosome_X_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/600px-Human_chromosome_X_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 129.59666341851px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CXCR3"><img alt="Genomic location for CXCR3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 135.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CXCR3"><img alt="Genomic location for CXCR3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">Xq13.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">71,615,916 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">71,618,511 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/260px-Ideogram_house_mouse_chromosome_X.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/390px-Ideogram_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/520px-Ideogram_house_mouse_chromosome_X.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">X chromosome (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/300px-Ideogram_of_house_mouse_chromosome_X.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/450px-Ideogram_of_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/600px-Ideogram_of_house_mouse_chromosome_X.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 167.91165088599px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for CXCR3"><img alt="Genomic location for CXCR3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 173.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for CXCR3"><img alt="Genomic location for CXCR3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">X D|X 44.58 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">100,775,141 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">100,777,875 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000186810">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">bone marrow</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">gallbladder</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000050232">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">zygote</li><br /><li style="line-height: 137%;">primary oocyte</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">submandibular gland</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">stroma of bone marrow</li><br /><li style="line-height: 137%;">granulocyte</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000186810">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CXCR3_207681_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_CXCR3_207681_at_fs.png/250px-PBB_GE_CXCR3_207681_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_CXCR3_207681_at_fs.png/375px-PBB_GE_CXCR3_207681_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_CXCR3_207681_at_fs.png/500px-PBB_GE_CXCR3_207681_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_CXCR3_217119_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/PBB_GE_CXCR3_217119_s_at_fs.png/250px-PBB_GE_CXCR3_217119_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/PBB_GE_CXCR3_217119_s_at_fs.png/375px-PBB_GE_CXCR3_217119_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a4/PBB_GE_CXCR3_217119_s_at_fs.png/500px-PBB_GE_CXCR3_217119_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2833/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016494">C-X-C chemokine receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004930">G protein-coupled receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019958">C-X-C chemokine binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019956">chemokine binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004950">chemokine receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038023">signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016493">C-C chemokine receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019957">C-C chemokine binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009897">external side of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005622">intracellular anatomical structure</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900118">negative regulation of execution phase of apoptosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900119">positive regulation of execution phase of apoptosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007204">positive regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010818">T cell chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070098">chemokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051281">positive regulation of release of sequestered calcium ion into cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043950">positive regulation of cAMP-mediated signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002685">regulation of leukocyte migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045766">positive regulation of angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001937">negative regulation of endothelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007166">cell surface receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050921">positive regulation of chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001525">angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071954">chemokine (C-C motif) ligand 11 production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016525">negative regulation of angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019722">calcium-mediated signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006915">apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006935">chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007189">adenylate cyclase-activating G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006955">immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060326">cell chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030155">regulation of cell adhesion</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2833&rn=1">2833</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12766&rn=1">12766</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000186810;db=core">ENSG00000186810</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000050232;db=core">ENSMUSG00000050232</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P49682">P49682</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O88410">O88410</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001142797">NM_001142797</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001504">NM_001504</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009910">NM_009910</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001136269">NP_001136269</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001495">NP_001495</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034040">NP_034040</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chrX:71615916-71618511">Chr X: 71.62 – 71.62 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chrX:100775141-100777875">Chr X: 100.78 – 100.78 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14911979" class="extiw" title="d:Q14911979">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14911980" class="extiw" title="d:Q14911980">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Chemokine receptor CXCR3</b> is a Gα<sub>i</sub> protein-coupled receptor in the <a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC chemokine receptor</a> family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt).<sup id="cite_ref-clinsci.org_5-0" class="reference"><a href="#cite_note-clinsci.org-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> <b>CXCR3-A</b> binds to the CXC chemokines <a href="/wiki/CXCL9" title="CXCL9">CXCL9</a> (MIG), <a href="/wiki/CXCL10" title="CXCL10">CXCL10</a> (IP-10), and <a href="/wiki/CXCL11" title="CXCL11">CXCL11</a> (I-TAC)<sup id="cite_ref-pmid12417585_6-0" class="reference"><a href="#cite_note-pmid12417585-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> whereas <b>CXCR3-B</b> can also bind to <a href="/wiki/CXCL4" class="mw-redirect" title="CXCL4">CXCL4</a> in addition to CXCL9, CXCL10, and CXCL11.<sup id="cite_ref-pmid12782716_7-0" class="reference"><a href="#cite_note-pmid12782716-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Expression">Expression</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=1" title="Edit section: Expression"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CXCR3 is expressed primarily on activated <a href="/wiki/T_lymphocytes" class="mw-redirect" title="T lymphocytes">T lymphocytes</a> and <a href="/wiki/NK_cells" class="mw-redirect" title="NK cells">NK cells</a>,<sup id="cite_ref-pmid9466968_8-0" class="reference"><a href="#cite_note-pmid9466968-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> and some epithelial cells. CXCR3 and <a href="/wiki/CCR5" title="CCR5">CCR5</a> are preferentially expressed on <a href="/wiki/Th1_cell" class="mw-redirect" title="Th1 cell">Th1 cells</a>, whereas Th2 cells favor the expression of <a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a> and <a href="/wiki/CCR4" title="CCR4">CCR4</a>. CXCR3 ligands that attract Th1 cells can concomitantly block the migration of Th2 cells in response to CCR3 ligands, thus enhancing the polarization of effector T cell recruitment. </p> <div class="mw-heading mw-heading2"><h2 id="Signal_transduction">Signal transduction</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=2" title="Edit section: Signal transduction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Binding of CXCL9, CXCL10, and CXCL11 to CXCR3 is able to elicit increases in intracellular Ca<sup>2++</sup> levels and activate <a href="/wiki/Phosphoinositide_3-kinase" title="Phosphoinositide 3-kinase">phosphoinositide 3-kinase</a> and <a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">mitogen-activated protein kinase</a> (MAPK).<sup id="cite_ref-pmid12750173_9-0" class="reference"><a href="#cite_note-pmid12750173-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Detailed signaling pathway has not yet been established, but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably <a href="/wiki/Integrin" title="Integrin">integrin</a> activation, cytoskeletal changes and <a href="/wiki/Chemotaxis" title="Chemotaxis">chemotactic migration</a>. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation. </p><p>As a consequence of chemokine-induced cellular <a href="/wiki/Receptor_(biochemistry)#Receptor_desensitization" title="Receptor (biochemistry)">desensitization</a> (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after <a href="/wiki/Dephosphorylation" title="Dephosphorylation">dephosphorylation</a> of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CXCR3 is its prominent expression in <i>in vitro</i> cultured <a href="/wiki/Memory_T_cells" class="mw-redirect" title="Memory T cells">effector/memory T cells</a>, and in T cells present in many types of inflamed tissues. In addition, CXCL9, CXCL10 and CXCL11 are commonly produced by local cells in inflammatory lesion, suggesting that CXCR3 and its chemokines participate in the recruitment of inflammatory cells.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Additionally, CXCR3 has been implicated in wound healing.<sup id="cite_ref-pmid17600132_11-0" class="reference"><a href="#cite_note-pmid17600132-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=4" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>CXCR3 has been implicated in the following diseases <a href="/wiki/Atherosclerosis" title="Atherosclerosis">atherosclerosis</a>,<sup id="cite_ref-pmid10525042_12-0" class="reference"><a href="#cite_note-pmid10525042-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Multiple_sclerosis" title="Multiple sclerosis">multiple sclerosis</a>,<sup id="cite_ref-pmid10079101_13-0" class="reference"><a href="#cite_note-pmid10079101-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Pulmonary_fibrosis" title="Pulmonary fibrosis">pulmonary fibrosis</a>,<sup id="cite_ref-pmid15254596_14-0" class="reference"><a href="#cite_note-pmid15254596-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Type_1_diabetes" title="Type 1 diabetes">type 1 diabetes</a>,<sup id="cite_ref-pmid12415259_15-0" class="reference"><a href="#cite_note-pmid12415259-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> autoimmune myasthenia gravis, <a href="/w/index.php?title=Nephrotoxic_nephritis&action=edit&redlink=1" class="new" title="Nephrotoxic nephritis (page does not exist)">nephrotoxic nephritis</a>,<sup id="cite_ref-pmid17538187_16-0" class="reference"><a href="#cite_note-pmid17538187-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> acute cardiac allograft rejection,<sup id="cite_ref-pmid11085753_17-0" class="reference"><a href="#cite_note-pmid11085753-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Allergic_contact_dermatitis" title="Allergic contact dermatitis">allergic contact dermatitis</a>,<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> and possibly Celiac Disease.<sup id="cite_ref-pmid18485912_19-0" class="reference"><a href="#cite_note-pmid18485912-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> It may also have implications in lung tissue repair after exposure to cigarette smoking.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Development of agents to block CXCR3-ligand interactions may provide new ways to treat these diseases. In addition, CXCR3 has been implicated in inflammatory brain damage in central nervous system (CNS) infections<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Cardiovascular_implications">Cardiovascular implications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=5" title="Edit section: Cardiovascular implications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Evidence from pre-clinical and clinical investigations has revealed the involvement of CXCR3 and its ligands in several cardiovascular diseases (CVDs) of diverse etiologies including atherosclerosis, hypertension, Kawasaki disease, myocarditis, dilated cardiomyopathies, Chagas, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD).<sup id="cite_ref-clinsci.org_5-1" class="reference"><a href="#cite_note-clinsci.org-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> CXCL9-10-11 have been recognized to be valid biomarkers for the development of heart failure and left ventricular dysfunction in two pilot studies, suggesting an underlining correlation between levels of the interferon (IFN)-γ-inducible chemokines and the development of adverse cardiac remodeling.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> <sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=6" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Recent reports indicate that there is a significant interest for the identification of small-molecule antagonists of CXCR3.<sup id="cite_ref-pmid18032038_30-0" class="reference"><a href="#cite_note-pmid18032038-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> Several small molecules <sup id="cite_ref-pmid17964154_31-0" class="reference"><a href="#cite_note-pmid17964154-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> were found to constitute a promising series of functional antagonists of CXCR3 that could be developed into new therapeutic agents for the treatment of inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diabetes. More recently the first QSAR study concerning antagonists of CXCR3 has been published in the literature. The in silico model provides a time- and cost-effective tool for the screening of existing and virtual libraries of small molecules as well as for designing of novel molecules of desired activity.<sup id="cite_ref-pmid18619714_32-0" class="reference"><a href="#cite_note-pmid18619714-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=7" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Chemokine_receptors" class="mw-redirect" title="Chemokine receptors">Chemokine receptors</a></li> <li><a href="/wiki/Chemokine" title="Chemokine">Chemokine</a></li> <li><a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">Cluster of differentiation</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000186810">GRCh38: Ensembl release 89: ENSG00000186810</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> 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"A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4] diazepane ureas". <i>European Journal of Medicinal Chemistry</i>. <b>44</b> (2): 877–884. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ejmech.2008.05.028">10.1016/j.ejmech.2008.05.028</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18619714">18619714</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Journal+of+Medicinal+Chemistry&rft.atitle=A+novel+QSAR+model+for+predicting+the+inhibition+of+CXCR3+receptor+by+4-N-aryl-%5B1%2C4%5D+diazepane+ureas&rft.volume=44&rft.issue=2&rft.pages=877-884&rft.date=2009-02&rft_id=info%3Adoi%2F10.1016%2Fj.ejmech.2008.05.028&rft_id=info%3Apmid%2F18619714&rft.aulast=Afantitis&rft.aufirst=A&rft.au=Melagraki%2C+G&rft.au=Sarimveis%2C+H&rft.au=Igglessi-Markopoulou%2C+O&rft.au=Kollias%2C+G&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACXCR3" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=CXCR3&action=edit&section=9" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2214">"Chemokine Receptors: CXCR3"</a>. <i>IUPHAR Database of Receptors and Ion Channels</i>. International Union of Basic and Clinical Pharmacology.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=IUPHAR+Database+of+Receptors+and+Ion+Channels&rft.atitle=Chemokine+Receptors%3A+CXCR3&rft_id=http%3A%2F%2Fwww.iuphar-db.org%2FGPCR%2FReceptorDisplayForward%3FreceptorID%3D2214&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACXCR3" class="Z3988"></span></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=CD183+Antigen">CD183+Antigen</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CXCR3"><i>CXCR3</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CXCR3"><i>CXCR3</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist 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title="Special:EditPage/Template:Cytokine receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytokine_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytokine_receptor" title="Cytokine receptor">Cytokine receptors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine receptor</a><br />(<a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">GPCRs</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CC_chemokine_receptors" title="CC chemokine receptors">CC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCR1" title="CCR1">CCR1</a> / <a href="/wiki/CCRL1" title="CCRL1">CCRL1</a></li> <li><a href="/wiki/CCR2" title="CCR2">CCR2</a></li> <li><a href="/wiki/CCRL2" title="CCRL2">CCRL2</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a></li> <li><a href="/wiki/CCR4" title="CCR4">CCR4</a></li> <li><a href="/wiki/CCR5" title="CCR5">CCR5</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CCR6</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CCR7</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CCR8</a></li> <li><a href="/wiki/CCR9" title="CCR9">CCR9</a></li> <li><a href="/wiki/CCR10" title="CCR10">CCR10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a> <ul><li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CXCR1</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CXCR2</a></li></ul></li> <li><a class="mw-selflink selflink">CXCR3</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CXCR4</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CXCR5</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CXCR6</a></li> <li><a href="/wiki/ACKR3" title="ACKR3">CXCR7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>CX3C <ul><li><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3CR1</a></li></ul></li> <li>XC <ul><li><a href="/wiki/XCR1" title="XCR1">XCR1</a></li></ul></li> <li><a href="/wiki/CCBP2" title="CCBP2">CCBP2</a></li> <li><a href="/wiki/CMKLR1" title="CMKLR1">CMKLR1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Tumor_necrosis_factor_receptor" class="mw-redirect" title="Tumor necrosis factor receptor">TNF receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1-10</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_receptor_1" title="Tumor necrosis factor receptor 1">TNFR1</a> <i>(TNFRSF1A)</i></li> <li><a href="/wiki/Tumor_necrosis_factor_receptor_2" title="Tumor necrosis factor receptor 2">TNFR2</a> <i>(TNFRSF1B)</i></li> <li><a href="/wiki/Lymphotoxin_beta_receptor" title="Lymphotoxin beta receptor">LTBR</a> <i>(TNFRSF3)</i></li> <li><a href="/wiki/CD134" title="CD134">CD134</a> <i>(TNFRSF4)</i></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a> <i>(TNFRSF5)</i></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">Fas receptor</a> <i>(TNFRSF6)</i></li> <li><a href="/wiki/DcR3" class="mw-redirect" title="DcR3">DcR3</a> <i>(TNFRSF6B)</i></li> <li><a href="/wiki/CD27" title="CD27">CD27</a> <i>(TNFRSF7)</i></li> <li><a href="/wiki/CD30" title="CD30">CD30</a> <i>(TNFRSF8)</i></li> <li><a href="/wiki/CD137" title="CD137">CD137</a> <i>(TNFRSF9)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">11-20</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_4" title="Death receptor 4">DR4</a> <i>(TNFRSF10A)</i></li> <li><a href="/wiki/Death_receptor_5" title="Death receptor 5">DR5</a> <i>(TNFRSF10B)</i></li> <li><a href="/wiki/Decoy_receptor_1" title="Decoy receptor 1">DcR1</a> <i>(TNFRSF10C)</i></li> <li><a href="/wiki/Decoy_receptor_2" title="Decoy receptor 2">DcR2</a> <i>(TNFRSF10D)</i></li> <li><a href="/wiki/RANK" title="RANK">RANK</a> <i>(TNFRSF11A)</i></li> <li><a href="/wiki/Osteoprotegerin" title="Osteoprotegerin">Osteoprotegerin</a> <i>(TNFRSF11B)</i></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">TweakR</a> <i>(TNFRSF12A)</i></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">TACI</a> <i>(TNFRSF13B)</i></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">BAFFR</a> <i>(TNFRSF13C)</i></li> <li><a href="/wiki/TNFRSF14" class="mw-redirect" title="TNFRSF14">HVEM</a> <i>(TNFRSF14)</i></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">NGFR</a> <i>(TNFRSF16)</i></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">BCMA</a> <i>(TNFRSF17)</i></li> <li><a href="/wiki/TNFRSF18" title="TNFRSF18">GITR</a> <i>(TNFRSF18)</i></li> <li><a href="/wiki/TNFRSF19" title="TNFRSF19">TAJ/TROY</a> <i>(TNFRSF19)</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">21-27</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Death_receptor_6" title="Death receptor 6">DR6</a> <i>(TNFRSF21)</i></li> <li><a href="/wiki/Death_receptor_3" title="Death receptor 3">DR3</a> <i>(TNFRSF25)</i></li> <li><a href="/wiki/Ectodysplasin_A2_receptor" title="Ectodysplasin A2 receptor">EDA2R</a> <i>(TNFRSF27)</i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ-chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/IL-2_receptor" title="IL-2 receptor">IL2R</a> / <a href="/wiki/IL2RA" title="IL2RA">IL2RA</a>/<a href="/wiki/IL2RB" title="IL2RB">IL2RB</a> / <a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL15R</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL4R</a> / <a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL13R</a> / <a href="/wiki/Interleukin_13_receptor,_alpha_1" title="Interleukin 13 receptor, alpha 1">IL13RA1</a> / <a href="/wiki/IL13RA2" title="IL13RA2">IL13RA2</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL7R</a> / <a href="/wiki/Interleukin-7_receptor-%CE%B1" title="Interleukin-7 receptor-α">IL7RA</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">IL9R</a></li> <li><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL21R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/CSF2RB" title="CSF2RB">β-chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL3R</a> / <a href="/wiki/IL3RA" title="IL3RA">IL3RA</a></li> <li><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL5R</a> / <a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">IL5RA</a></li></ul></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">GM-CSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL6RA</a></li> <li><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">11</a>/<a href="/wiki/Interleukin_11_receptor_alpha_subunit" title="Interleukin 11 receptor alpha subunit">IL11RA</a></li> <li><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">27</a>/<a href="/wiki/Interleukin_27_receptor,_alpha_subunit" title="Interleukin 27 receptor, alpha subunit">IL27RA</a></li></ul></li> <li><a href="/wiki/Oncostatin_M_receptor" title="Oncostatin M receptor">OSMR</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">LIFR</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTFR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL12R</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB2</a></li> <li><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL23R</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>other <a href="/wiki/CSF_receptors" class="mw-redirect" title="CSF receptors">CSF receptors</a> <ul><li><a href="/wiki/Erythropoietin_receptor" title="Erythropoietin receptor">EPO</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">G-CSF</a></li> <li><a href="/wiki/Thrombopoietin_receptor" title="Thrombopoietin receptor">Thrombopoietin</a></li></ul></li></ul> <ul><li><a href="/wiki/Hormone_receptor" title="Hormone receptor">hormone receptor</a>: <a href="/wiki/Growth_hormone_receptor" title="Growth hormone receptor">GH</a></li> <li><a href="/wiki/Prolactin_receptor" title="Prolactin receptor">prolactin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptors</a> <ul><li><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL10R</a> / <a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">IL10RA</a> / <a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL10RB</a> / <a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL22R</a> / <a href="/wiki/IL22RA1" title="IL22RA1">IL22RA1</a> / <a href="/wiki/IL22RA2" title="IL22RA2">IL22RA2</a></li> <li><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL20R</a> / <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL20RA</a> / <a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL20RB</a></li> <li><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL28R</a></li></ul></li> <li><a href="/wiki/Interferon_receptor" class="mw-redirect" title="Interferon receptor">Interferon receptors</a> <ul><li><a href="/wiki/Interferon-alpha/beta_receptor" title="Interferon-alpha/beta receptor">-α/β</a> / <a href="/wiki/IFNAR1" title="IFNAR1">IFNAR1</a>/<a href="/wiki/IFNAR2" title="IFNAR2">IFNAR2</a></li> <li><a href="/wiki/Interferon-gamma_receptor" title="Interferon-gamma receptor">-γ</a>/<a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">IFNGR1</a> / <a href="/wiki/Interferon_gamma_receptor_2" title="Interferon gamma receptor 2">IFNGR2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li class="mw-empty-elt"></li> <li><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL1</a> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">IL1R1</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">IL1R2</a></li></ul></li> <li><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL18R</a> / <a href="/wiki/IL18R1" title="IL18R1">IL18R1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/IL_17_family" class="mw-redirect" title="IL 17 family">IL 17 family</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL17</a> <ul><li><a href="/wiki/IL17RA" title="IL17RA">IL17RA</a></li> <li><a href="/wiki/IL17RB" title="IL17RB">IL17RB</a></li> <li><a href="/wiki/IL17RC" title="IL17RC">IL17RC</a></li> <li><a href="/wiki/IL17RD" title="IL17RD">IL17RD</a></li> <li><a href="/w/index.php?title=IL17RE&action=edit&redlink=1" class="new" title="IL17RE (page does not exist)">IL17RE</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Enzyme-linked_receptor" title="Enzyme-linked receptor">Enzyme-linked receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Tyr</a> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li></ul></li> <li><a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">Ser/Thr</a>: <a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF-beta</a> <ul><li><a href="/wiki/TGF_beta_receptor_1" title="TGF beta receptor 1">TGFBR1</a></li> <li><a href="/wiki/TGF_beta_receptor_2" title="TGF beta receptor 2">TGFBR2</a></li> <li><a href="/wiki/TGF-beta_receptor_family" title="TGF-beta receptor family">family</a></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Clusters_of_differentiation" title="Template:Clusters of differentiation"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation" title="Template talk:Clusters of differentiation"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation" title="Special:EditPage/Template:Clusters of differentiation"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">clusters of differentiation</a> (see also <a href="/wiki/List_of_human_clusters_of_differentiation" title="List of human clusters of differentiation">list of human clusters of differentiation</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1–50</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a> <ul><li><a href="/wiki/Group_1_CD1" class="mw-redirect" title="Group 1 CD1">a-c</a></li> <li><a href="/wiki/CD1A" title="CD1A">1A</a></li> <li><a href="/wiki/CD1b" title="CD1b">1B</a></li> <li><a href="/wiki/CD1D" title="CD1D">1D</a></li> <li><a href="/wiki/CD1E" title="CD1E">1E</a></li></ul></li> <li><a href="/wiki/CD2" title="CD2">CD2</a></li> <li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a> <ul><li><a href="/wiki/CD3G" title="CD3G">γ</a></li> <li><a href="/wiki/CD3D" title="CD3D">δ</a></li> <li><a href="/wiki/CD3E" class="mw-redirect" title="CD3E">ε</a></li></ul></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li> <li><a href="/wiki/CD6" title="CD6">CD6</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a> <ul><li><a href="/wiki/CD8A" title="CD8A">a</a></li></ul></li> <li><a href="/wiki/CD9" title="CD9">CD9</a></li> <li><a href="/wiki/Neprilysin" title="Neprilysin">CD10</a></li> <li><i>CD11</i> <ul><li><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">a</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">b</a></li> <li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">c</a></li> <li><a href="/wiki/ITGAD" class="mw-redirect" title="ITGAD">d</a></li></ul></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a href="/wiki/CD16" title="CD16">CD16</a> <ul><li><a href="/wiki/FCGR3A" title="FCGR3A">A</a></li> <li><a href="/wiki/FCGR3B" title="FCGR3B">B</a></li></ul></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD23" title="CD23">CD23</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/IL2RA" title="IL2RA">CD25</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li> <li><a href="/wiki/Integrin_beta_1" title="Integrin beta 1">CD29</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/CD31" title="CD31">CD31</a></li> <li><a href="/wiki/CD32" title="CD32">CD32</a> <ul><li><a href="/wiki/FCGR2A" title="FCGR2A">A</a></li> <li><a href="/wiki/FCGR2B" title="FCGR2B">B</a></li></ul></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/CD34" title="CD34">CD34</a></li> <li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CD35</a></li> <li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD37" title="CD37">CD37</a></li> <li><a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/ENTPD1" title="ENTPD1">CD39</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li> <li><a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">CD41</a></li> <li><a href="/wiki/Glycoprotein_Ib" title="Glycoprotein Ib">CD42</a> <ul><li><a href="/wiki/Glycoprotein_IX" title="Glycoprotein IX">a</a></li> <li><a href="/wiki/GP1BA" title="GP1BA">b</a></li> <li><a href="/wiki/GP1BB" title="GP1BB">c</a></li> <li><a href="/wiki/GP5_(gene)" title="GP5 (gene)">d</a></li></ul></li> <li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/PTPRC" title="PTPRC">CD45</a></li> <li><a href="/wiki/CD46" title="CD46">CD46</a></li> <li><a href="/wiki/CD47" title="CD47">CD47</a></li> <li><a href="/wiki/CD48" title="CD48">CD48</a></li> <li><i>CD49</i> <ul><li><a href="/wiki/CD49a" class="mw-redirect" title="CD49a">a</a></li> <li><a href="/wiki/CD49b" class="mw-redirect" title="CD49b">b</a></li> <li><a href="/wiki/CD49c" class="mw-redirect" title="CD49c">c</a></li> <li><a href="/wiki/CD49d" class="mw-redirect" title="CD49d">d</a></li> <li><a href="/wiki/ITGA5" class="mw-redirect" title="ITGA5">e</a></li> <li><a href="/wiki/ITGA6" class="mw-redirect" title="ITGA6">f</a></li></ul></li> <li><a href="/wiki/ICAM3" title="ICAM3">CD50</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">51–100</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ITGAV" class="mw-redirect" title="ITGAV">CD51</a></li> <li><a href="/wiki/CD52" title="CD52">CD52</a></li> <li><a href="/wiki/CD53" title="CD53">CD53</a></li> <li><a href="/wiki/ICAM-1" title="ICAM-1">CD54</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">CD55</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56</a></li> <li><a href="/wiki/B3GAT1" title="B3GAT1">CD57</a></li> <li><a href="/wiki/CD58" title="CD58">CD58</a></li> <li><a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li> <li><a href="/wiki/Selectin" title="Selectin">CD62</a> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P</a></li></ul></li> <li><a href="/wiki/CD63" title="CD63">CD63</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a> <ul><li><a href="/wiki/FCGR1A" title="FCGR1A">A</a></li> <li><a href="/wiki/FCGR1B" class="mw-redirect" title="FCGR1B">B</a></li> <li><a href="/wiki/FCGR1C" class="mw-redirect" title="FCGR1C">C</a></li></ul></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">CD66</a> <ul><li><a href="/wiki/CEACAM1" title="CEACAM1">a</a></li> <li><a href="/wiki/CEACAM8" title="CEACAM8">b</a></li> <li><a href="/wiki/CEACAM6" title="CEACAM6">c</a></li> <li><a href="/wiki/CEACAM3" title="CEACAM3">d</a></li> <li><a href="/wiki/CEACAM5" title="CEACAM5">e</a></li> <li><a href="/wiki/PSG1_(gene)" class="mw-redirect" title="PSG1 (gene)">f</a></li></ul></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li> <li><a href="/wiki/CD69" title="CD69">CD69</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/TFRC" class="mw-redirect" title="TFRC">CD71</a></li> <li><a href="/wiki/CD72" title="CD72">CD72</a></li> <li><a href="/wiki/NT5E" title="NT5E">CD73</a></li> <li><a href="/wiki/CD74" title="CD74">CD74</a></li> <li><a href="/wiki/CD78" title="CD78">CD78</a></li> <li><a href="/wiki/CD79" title="CD79">CD79</a> <ul><li><a href="/wiki/CD79A" title="CD79A">a</a></li> <li><a href="/wiki/CD79B" title="CD79B">b</a></li></ul></li> <li><a href="/wiki/CD80" title="CD80">CD80</a></li> <li><a href="/wiki/CD81" title="CD81">CD81</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">CD82</a></li> <li><a href="/wiki/CD83" title="CD83">CD83</a></li> <li><a href="/wiki/CD84" title="CD84">CD84</a></li> <li><i>CD85</i> <ul><li><a href="/wiki/LILRB3" title="LILRB3">a</a></li> <li><a href="/wiki/LILRB2" title="LILRB2">d</a></li> <li><a href="/wiki/LILRA3" title="LILRA3">e</a></li> <li><a href="/wiki/LILRA2" title="LILRA2">h</a></li> <li><a href="/wiki/LILRB1" title="LILRB1">j</a></li> <li><a href="/wiki/LILRB4" title="LILRB4">k</a></li></ul></li> <li><a href="/wiki/CD86" title="CD86">CD86</a></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">CD87</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">CD88</a></li> <li><a href="/wiki/FCAR" title="FCAR">CD89</a></li> <li><a href="/wiki/CD90" title="CD90">CD90</a></li> <li><a href="/wiki/LRP1" title="LRP1">CD91</a> - <a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">CD92</a></li> <li><a href="/wiki/CD93" title="CD93">CD93</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">CD94</a></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">CD95</a></li> <li><a href="/wiki/CD96" title="CD96">CD96</a></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li> <li><a href="/wiki/CD98" title="CD98">CD98</a></li> <li><a href="/wiki/CD99" title="CD99">CD99</a></li> <li><a href="/wiki/SEMA4D" title="SEMA4D">CD100</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">101–150</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IGSF2" title="IGSF2">CD101</a></li> <li><a href="/wiki/ICAM2" title="ICAM2">CD102</a></li> <li><a href="/wiki/ITGAE" title="ITGAE">CD103</a></li> <li><a href="/wiki/ITGB4" class="mw-redirect" title="ITGB4">CD104</a></li> <li><a href="/wiki/Endoglin" title="Endoglin">CD105</a></li> <li><a href="/wiki/VCAM-1" title="VCAM-1">CD106</a></li> <li><i>CD107</i> <ul><li><a href="/wiki/LAMP1" title="LAMP1">a</a></li> <li><a href="/wiki/LAMP2" title="LAMP2">b</a></li></ul></li> <li><a href="/wiki/SEMA7A" title="SEMA7A">CD108</a></li> <li><a href="/wiki/CD109" title="CD109">CD109</a></li> <li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">CD110</a></li> <li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">CD111</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">CD112</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">CD113</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">CD114</a></li> <li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CD115</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CD116</a></li> <li><a href="/wiki/KIT_(gene)" title="KIT (gene)">CD117</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">CD118</a></li> <li><a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">CD119</a></li> <li><a href="/wiki/CD120" title="CD120">CD120</a> <ul><li><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">a</a></li> <li><a href="/wiki/TNFRSF1B" class="mw-redirect" title="TNFRSF1B">b</a></li></ul></li> <li><i>CD121</i> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">a</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">b</a></li></ul></li> <li><a href="/wiki/IL2RB" title="IL2RB">CD122</a></li> <li><a href="/wiki/IL3RA" title="IL3RA">CD123</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">CD124</a></li> <li><a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">CD125</a></li> <li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">CD126</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">CD129</a></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">CD130</a></li> <li><a href="/wiki/CSF2RB" title="CSF2RB">CD131</a></li> <li><a href="/wiki/Common_gamma_chain" title="Common gamma chain">CD132</a></li> <li><a href="/wiki/CD133" title="CD133">CD133</a></li> <li><a href="/wiki/CD134" title="CD134">CD134</a></li> <li><a href="/wiki/CD135" title="CD135">CD135</a></li> <li><a href="/wiki/MST1R" title="MST1R">CD136</a></li> <li><a href="/wiki/CD137" title="CD137">CD137</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">CD140b</a></li> <li><a href="/wiki/Thrombomodulin" title="Thrombomodulin">CD141</a></li> <li><a href="/wiki/Tissue_factor" title="Tissue factor">CD142</a></li> <li><a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">CD143</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CD144</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Basigin" title="Basigin">CD147</a></li> <li><a href="/wiki/PTPRJ" title="PTPRJ">CD148</a></li> <li><a href="/wiki/SLAMF1" title="SLAMF1">CD150</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">151–200</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD151" title="CD151">CD151</a></li> <li><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CD152</a></li> <li><a href="/wiki/CD153" title="CD153">CD153</a></li> <li><a href="/wiki/CD154" title="CD154">CD154</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li> <li><i>CD156</i> <ul><li><a href="/wiki/ADAM8" title="ADAM8">a</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">b</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">c</a></li></ul></li> <li><a href="/wiki/BST1" title="BST1">CD157</a></li> <li><i>CD158</i> (<a href="/wiki/KIR2DL1" title="KIR2DL1">a</a></li> <li><a href="/wiki/KIR2DL4" title="KIR2DL4">d</a></li> <li><a href="/wiki/KIR3DL1" title="KIR3DL1">e</a></li> <li><a href="/wiki/KIR2DS4" title="KIR2DS4">i</a></li> <li><a href="/wiki/KIR3DL2" title="KIR3DL2">k</a>)</li> <li><i>CD159</i> <ul><li><a href="/wiki/NKG2" title="NKG2">a</a></li> <li><a href="/wiki/KLRC2" title="KLRC2">c</a></li></ul></li> <li><a href="/wiki/CD160" title="CD160">CD160</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">CD161</a></li> <li><a href="/wiki/P-selectin_glycoprotein_ligand-1" title="P-selectin glycoprotein ligand-1">CD162</a></li> <li><a href="/wiki/CD163" title="CD163">CD163</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/ALCAM" title="ALCAM">CD166</a></li> <li><i>CD167</i> <ul><li><a href="/wiki/DDR1" title="DDR1">a</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">b</a></li></ul></li> <li><a href="/wiki/Hyaluronan-mediated_motility_receptor" title="Hyaluronan-mediated motility receptor">CD168</a></li> <li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">CD169</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">CD170</a></li> <li><a href="/wiki/L1_(protein)" title="L1 (protein)">CD171</a></li> <li><i>CD172</i> <ul><li><a href="/wiki/Signal-regulatory_protein_alpha" title="Signal-regulatory protein alpha">a</a></li> <li><a href="/wiki/SIRPB1" title="SIRPB1">b</a></li> <li><a href="/wiki/SIRPG" title="SIRPG">g</a></li></ul></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">CD174</a></li> <li><a href="/wiki/CD177" title="CD177">CD177</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">CD178</a></li> <li><i>CD179</i> <ul><li><a href="/wiki/VPREB1" title="VPREB1">a</a></li> <li><a href="/wiki/IGLL1" title="IGLL1">b</a></li></ul></li> <li><a href="/wiki/CD180" title="CD180">CD180</a></li> <li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CD181</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CD182</a></li> <li><a class="mw-selflink selflink">CD183</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CD184</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CD185</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CD186</a></li> <li><a href="/wiki/CCR1" title="CCR1">CD191</a></li> <li><a href="/wiki/CCR2" title="CCR2">CD192</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CD193</a></li> <li><a href="/wiki/CCR4" title="CCR4">CD194</a></li> <li><a href="/wiki/CCR5" title="CCR5">CD195</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CD196</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CD197</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CDw198</a></li> <li><a href="/wiki/CCR9" title="CCR9">CDw199</a></li> <li><a href="/wiki/CD200" title="CD200">CD200</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">201–250</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endothelial_protein_C_receptor" title="Endothelial protein C receptor">CD201</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">CD202b</a></li> <li><a href="/wiki/MSR1" title="MSR1">CD204</a></li> <li><a href="/wiki/LY75" class="mw-redirect" title="LY75">CD205</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD206</a></li> <li><a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a></li> <li><a href="/wiki/LAMP3" title="LAMP3">CD208</a></li> <li><a href="/wiki/DC-SIGN" title="DC-SIGN">CD209</a></li> <li><i>CDw210</i> <ul><li><a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">a</a></li> <li><a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">b</a></li></ul></li> <li><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">CD212</a></li> <li><i>CD213a</i> <ul><li><a href="/wiki/IL13RA1" class="mw-redirect" title="IL13RA1">1</a></li> <li><a href="/wiki/IL13RA2" title="IL13RA2">2</a></li></ul></li> <li><a href="/wiki/IL17RA" title="IL17RA">CD217</a></li> <li><i>CD218</i> (<a href="/wiki/IL18R1" title="IL18R1">a</a></li> <li><a href="/wiki/IL18RAP" title="IL18RAP">b</a>)</li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">CD220</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">CD221</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">CD222</a></li> <li><a href="/wiki/LAG3" class="mw-redirect" title="LAG3">CD223</a></li> <li><a href="/wiki/GGT1" class="mw-redirect" title="GGT1">CD224</a></li> <li><a href="/wiki/IFITM1" title="IFITM1">CD225</a></li> <li><a href="/wiki/CD226" title="CD226">CD226</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">CD227</a></li> <li><a href="/wiki/MFI2" class="mw-redirect" title="MFI2">CD228</a></li> <li><a href="/wiki/LY9" title="LY9">CD229</a></li> <li><a href="/wiki/PRNP" class="mw-redirect" title="PRNP">CD230</a></li> <li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">CD233</a></li> <li><a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">CD234</a></li> <li><i>CD235</i> <ul><li><a href="/wiki/GYPA" class="mw-redirect" title="GYPA">a</a></li> <li><a href="/wiki/GYPB" title="GYPB">b</a></li></ul></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">CD236</a></li> <li><a href="/wiki/Kell_antigen_system" title="Kell antigen system">CD238</a></li> <li><a href="/wiki/Basal_cell_adhesion_molecule" title="Basal cell adhesion molecule">CD239</a></li> <li><a href="/wiki/RHCE_(gene)" title="RHCE (gene)">CD240CE</a></li> <li><a href="/wiki/RHD_(gene)" title="RHD (gene)">CD240D</a></li> <li><a href="/wiki/RHAG" title="RHAG">CD241</a></li> <li><a href="/wiki/P-glycoprotein" title="P-glycoprotein">CD243</a></li> <li><a href="/wiki/CD244" title="CD244">CD244</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">CD246</a></li> <li><a href="/wiki/CD247" class="mw-redirect" title="CD247">CD247</a> - <a href="/wiki/CD248" title="CD248">CD248</a></li> <li><a href="/wiki/Glutamyl_aminopeptidase" title="Glutamyl aminopeptidase">CD249</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">251–300</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L"> CD252</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">CD253</a></li> <li><a href="/wiki/RANKL" title="RANKL">CD254</a></li> <li><a href="/wiki/TNFSF13" class="mw-redirect" title="TNFSF13">CD256</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">CD257</a></li> <li><a href="/wiki/TNFSF14" class="mw-redirect" title="TNFSF14">CD258</a></li> <li><a href="/wiki/TNFRSF10A" class="mw-redirect" title="TNFRSF10A">CD261</a></li> <li><a href="/wiki/TNFRSF10B" class="mw-redirect" title="TNFRSF10B">CD262</a></li> <li><a href="/wiki/TNFRSF10C" class="mw-redirect" title="TNFRSF10C">CD263</a></li> <li><a href="/wiki/TNFRSF10D" class="mw-redirect" title="TNFRSF10D">CD264</a></li> <li><a href="/wiki/RANK" title="RANK">CD265</a></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">CD266</a></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">CD267</a></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">CD268</a></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">CD269</a></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">CD271</a></li> <li><a href="/wiki/BTLA" title="BTLA">CD272</a></li> <li><a href="/wiki/PDCD1LG2" title="PDCD1LG2">CD273</a></li> <li><a href="/wiki/CD274" class="mw-redirect" title="CD274">CD274</a></li> <li><a href="/wiki/ICOSLG" title="ICOSLG">CD275</a></li> <li><a href="/wiki/CD276" title="CD276">CD276</a></li> <li><a href="/wiki/CD278" title="CD278">CD278</a></li> <li><a href="/wiki/Programmed_cell_death_protein_1" title="Programmed cell death protein 1">CD279</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD280</a></li> <li><a href="/wiki/TLR_1" class="mw-redirect" title="TLR 1">CD281</a></li> <li><a href="/wiki/TLR2" class="mw-redirect" title="TLR2">CD282</a></li> <li><a href="/wiki/TLR3" class="mw-redirect" title="TLR3">CD283</a></li> <li><a href="/wiki/TLR4" class="mw-redirect" title="TLR4">CD284</a></li> <li><a href="/wiki/TLR6" class="mw-redirect" title="TLR6">CD286</a></li> <li><a href="/wiki/TLR8" class="mw-redirect" title="TLR8">CD288</a></li> <li><a href="/wiki/TLR9" class="mw-redirect" title="TLR9">CD289</a></li> <li><a href="/wiki/TLR10" class="mw-redirect" title="TLR10">CD290</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">CD292</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">CDw293</a></li> <li><a href="/wiki/CD294" class="mw-redirect" title="CD294">CD294</a></li> <li><a href="/wiki/Leptin_receptor" title="Leptin receptor">CD295</a></li> <li><a href="/wiki/ART4" title="ART4">CD297</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">CD298</a></li> <li><a href="/wiki/CLEC4M" title="CLEC4M">CD299</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">301–350</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD300A" title="CD300A">CD300A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CD301</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a></li> <li><a href="/wiki/CLEC4C" title="CLEC4C">CD303</a></li> <li><a href="/wiki/Neuropilin" title="Neuropilin">CD304</a></li> <li><a href="/wiki/LAIR1" title="LAIR1">CD305</a></li> <li><a href="/wiki/LAIR2" title="LAIR2">CD306</a></li> <li><a href="/wiki/FCRL5" title="FCRL5">CD307</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">CD309</a></li> <li><a href="/wiki/EMR2" title="EMR2">CD312</a></li> <li><a href="/wiki/NKG2D" title="NKG2D">CD314</a></li> <li><a href="/wiki/PTGFRN" title="PTGFRN">CD315</a></li> <li><a href="/wiki/IGSF8" title="IGSF8">CD316</a></li> <li><a href="/wiki/Tetherin" title="Tetherin">CD317</a></li> <li><a href="/wiki/CDCP1" title="CDCP1">CD318</a></li> <li><a href="/wiki/CD320" title="CD320">CD320</a></li> <li><a href="/wiki/F11_receptor" title="F11 receptor">CD321</a></li> <li><a href="/wiki/JAM2" title="JAM2">CD322</a></li> <li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CD324</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CD325</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">CD326</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">CD327</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">CD328</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">CD329</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">CD331</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">CD332</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">CD333</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">CD334</a></li> <li><a href="/wiki/NCR1" title="NCR1">CD335</a></li> <li><a href="/wiki/NCR2" title="NCR2">CD336</a></li> <li><a href="/wiki/NCR3" title="NCR3">CD337</a></li> <li><a href="/wiki/ABCG2" title="ABCG2">CD338</a></li> <li><a href="/wiki/JAG1" title="JAG1">CD339</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">CD340</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">CD344</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">CD349</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">CD350</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Chemokine_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chemokine_receptor_modulators" title="Template talk:Chemokine receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chemokine_receptor_modulators" title="Special:EditPage/Template:Chemokine receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Chemokine_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CC_chemokine_receptors" title="CC chemokine receptors">CC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR1" title="CCR1">CCR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL4" title="CCL4">CCL4 (MIP-1β)</a></li> <li><a href="/wiki/CCL5" title="CCL5">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL6" title="CCL6">CCL6</a></li> <li><a href="/wiki/CCL9" title="CCL9">CCL9 (CCL10)</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR2" title="CCR2">CCR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL2" title="CCL2">CCL2</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL12" title="CCL12">CCL12</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> <ul><li><i>NAMs:</i> <a href="/wiki/Cenicriviroc" title="Cenicriviroc">Cenicriviroc (TAK-652, TBR-652)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CCR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL5" title="CCL5">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL7" title="CCL7">CCL7</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL18" title="CCL18">CCL18</a></li> <li><a href="/wiki/CCL24" title="CCL24">CCL24</a></li> <li><a href="/wiki/CCL26" title="CCL26">CCL26</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR4" title="CCR4">CCR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL3" title="CCL3">CCL3 (MIP-1α)</a></li> <li><a href="/wiki/CCL5" title="CCL5">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/wiki/CCL22" title="CCL22">CCL22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Mogamulizumab" title="Mogamulizumab">Mogamulizumab</a> (against CCR4)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR5" title="CCR5">CCR5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL3" title="CCL3">CCL3 (MIP-1α)</a></li> <li><a href="/wiki/CCL4" title="CCL4">CCL4 (MIP-1β)</a></li> <li><a href="/wiki/CCL5" title="CCL5">CCL5 (RANTES)</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> <ul><li><i>NAMs:</i> <a href="/wiki/Aplaviroc" title="Aplaviroc">Aplaviroc</a></li> <li><a href="/wiki/Cenicriviroc" title="Cenicriviroc">Cenicriviroc (TAK-652, TBR-652)</a></li> <li><a href="/w/index.php?title=INCB009471&action=edit&redlink=1" class="new" title="INCB009471 (page does not exist)">INCB009471</a></li> <li><a href="/wiki/Maraviroc" title="Maraviroc">Maraviroc</a></li> <li><a href="/wiki/Vicriviroc" title="Vicriviroc">Vicriviroc</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/PRO_140" class="mw-redirect" title="PRO 140">PRO-140</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR6" class="mw-redirect" title="CCR6">CCR6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL20" title="CCL20">CCL20</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR7" class="mw-redirect" title="CCR7">CCR7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR8" class="mw-redirect" title="CCR8">CCR8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL1" title="CCL1">CCL1</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR9" title="CCR9">CCR9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL25" title="CCL25">CCL25</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR10" title="CCR10">CCR10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCR11" class="mw-redirect" title="CCR11">CCR11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li> <li><a href="/wiki/CCL25" title="CCL25">CCL25</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Antibodies:</i> <a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a> (against CCL11)</li> <li><a href="/wiki/Carlumab" title="Carlumab">Carlumab</a> (against CCL2)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXC_chemokine_receptors" title="CXC chemokine receptors">CXC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR1" class="mw-redirect" title="CXCR1">CXCR1<br /><small>(IL-8Rα)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/w/index.php?title=Emoctakin&action=edit&redlink=1" class="new" title="Emoctakin (page does not exist)">Emoctakin</a></li> <li><a href="/wiki/Interleukin-8" class="mw-redirect" title="Interleukin-8">Interleukin-8 (CXCL8, GCP-1)</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=Navarixin&action=edit&redlink=1" class="new" title="Navarixin (page does not exist)">Navarixin</a></li></ul> <ul><li><i>NAMs:</i> <a href="/w/index.php?title=Ladarixin&action=edit&redlink=1" class="new" title="Ladarixin (page does not exist)">Ladarixin</a></li> <li><a href="/w/index.php?title=Reparixin&action=edit&redlink=1" class="new" title="Reparixin (page does not exist)">Reparixin (repertaxin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR2" class="mw-redirect" title="CXCR2">CXCR2<br /><small>(IL-8Rβ)</small></a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL1" title="CXCL1">CXCL1 (MGSA)</a></li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/w/index.php?title=Emoctakin&action=edit&redlink=1" class="new" title="Emoctakin (page does not exist)">Emoctakin</a></li> <li><a href="/w/index.php?title=Garnocestim&action=edit&redlink=1" class="new" title="Garnocestim (page does not exist)">Garnocestim</a></li> <li><a href="/wiki/Interleukin-8" class="mw-redirect" title="Interleukin-8">Interleukin-8 (CXCL8, GCP-1)</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=Danirixin&action=edit&redlink=1" class="new" title="Danirixin (page does not exist)">Danirixin</a></li> <li><a href="/w/index.php?title=Elubrixin&action=edit&redlink=1" class="new" title="Elubrixin (page does not exist)">Elubrixin</a></li> <li><a href="/w/index.php?title=Navarixin&action=edit&redlink=1" class="new" title="Navarixin (page does not exist)">Navarixin</a></li></ul> <ul><li><i>NAMs:</i> <a href="/w/index.php?title=Ladarixin&action=edit&redlink=1" class="new" title="Ladarixin (page does not exist)">Ladarixin</a></li> <li><a href="/w/index.php?title=Reparixin&action=edit&redlink=1" class="new" title="Reparixin (page does not exist)">Reparixin (repertaxin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink">CXCR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL4" class="mw-redirect" title="CXCL4">CXCL4 (PF4)</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9 (MIG)</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10 (IP-10)</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11 (I-TAC)</a></li> <li><a href="/w/index.php?title=Iroplact&action=edit&redlink=1" class="new" title="Iroplact (page does not exist)">Iroplact</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Eldelumab" title="Eldelumab">Eldelumab</a> (against CXCL10)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR4" title="CXCR4">CXCR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li> <li><a href="/wiki/Stromal_cell-derived_factor_1" title="Stromal cell-derived factor 1">SDF-1 (CXCL12)</a></li> <li><a href="/wiki/Ubiquitin" title="Ubiquitin">Ubiquitin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Mavorixafor" title="Mavorixafor">Mavorixafor</a></li> <li><a href="/wiki/Plerixafor" title="Plerixafor">Plerixafor (AMD3100)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ulocuplumab" title="Ulocuplumab">Ulocuplumab</a> (against CXCR4)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR5" title="CXCR5">CXCR5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CXCR6" title="CXCR6">CXCR6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CXCL16" title="CXCL16">CXCL16</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/ACKR3" title="ACKR3">CXCR7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Conolidine" title="Conolidine">Conolidine</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11 (I-TAC)</a></li> <li><a href="/w/index.php?title=CCX771&action=edit&redlink=1" class="new" title="CCX771 (page does not exist)">CCX771</a></li> <li><a href="/wiki/LIH383" title="LIH383">LIH383</a></li> <li><a href="/wiki/RTI-5152-12" title="RTI-5152-12">RTI-5152-12</a></li> <li><a href="/wiki/Stromal_cell-derived_factor_1" title="Stromal cell-derived factor 1">SDF-1 (CXCL12)</a></li> <li><a href="/w/index.php?title=VUF15485&action=edit&redlink=1" class="new" title="VUF15485 (page does not exist)">VUF15485</a></li></ul> <ul><li><i>PAMs:</i> <a href="/wiki/Plerixafor" title="Plerixafor">Plerixafor (AMD3100)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/C_chemokine_receptor" class="mw-redirect" title="C chemokine receptor">C (XC)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="XCR1" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/XCR1" title="XCR1">XCR1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/XCL1" title="XCL1">Lymphotactin-α (XCL1)</a></li> <li><a href="/wiki/XCL2" title="XCL2">Lymphotactin-β (XCL2)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Pateclizumab" title="Pateclizumab">Pateclizumab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3C</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="CX3CR1" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CX3C_motif_chemokine_receptor_1" title="CX3C motif chemokine receptor 1">CX3CR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Fractalkine" class="mw-redirect" title="Fractalkine">Fractalkine (CX3CL1)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CCBP2" title="CCBP2">CCBP2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/CC_chemokine" class="mw-redirect" title="CC chemokine">CC (β) chemokines</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CMKLR1" title="CMKLR1">CMKLR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Chemerin" title="Chemerin">Chemerin</a></li> <li><a href="/w/index.php?title=Resolvin_E1&action=edit&redlink=1" class="new" title="Resolvin E1 (page does not exist)">Resolvin E1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=CXCR3&oldid=1241951118">https://en.wikipedia.org/w/index.php?title=CXCR3&oldid=1241951118</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_X" title="Category:Genes on human 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