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{"work":{"id":26703937,"created_at":"2016-07-03T15:33:46.934-07:00","from_world_paper_id":155084369,"updated_at":"2025-01-31T17:55:42.721-08:00","_data":{"ai_title_tag":"Cholesterol Dynamics in Transgenic Mice Models","grobid_abstract":"Human lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of cholesterol and is postulated to participate in the physiological process called reverse cholesterol transport. We have used transgenic mice (Tgm) expressing either both human apolipoprotein AI (apo AI) and human LCAT genes or only the human apo AI gene (HuAILCAT or HuAI Tgm, respectively) to assess the consequences of LCAT overexpression on serum lipid and lipoprotein profiles and on the ability of each serum to promote bidirectional flux of cholesterol between serum and Fu5AH hepatoma cells. Mean serum LCAT activity of HuAILCAT Tgm was 2-fold increased compared to the HuAI group (48 9 9 vs. 24 9 5 nmol/ml per h, PB 0.01 for HuAILCAT and HuAI Tgm, respectively) and the cholesterol esterification rates were not significantly different between the two groups of animals (66911 vs. 74918 nmol/ml per h for HuAILCAT and HuAI Tgm, respectively). HuAILCAT Tgm exhibited higher total cholesterol serum values (2.3-fold) due to an increase in both HDL-cholesterol (1.9-fold) and non-HDL-cholesterol (3-fold). The HDL particles from HuAILCAT Tgm were relatively phospholipid depleted and cholesterol enriched compared to HuAI mice. When cells were incubated for six hours with the mouse serum, the fractional efflux of radiolabeled cholesterol was slightly increased with the HuAILCAT Tgm (1.2-fold) but the increase in intracellular cholesterol content was also 2-fold higher than with the HuAI Tgm. Fu5AH can be viewed as a model for the evaluation of bidirectional flux of cholesterol in SR-BI-rich cells. In this model LCAT overexpression in mice, by increasing both HDL and non-HDL-cholesterol, mostly enhances the uptake of cholesterol by the cells, which would be of benefit for the last step of reverse cholesterol transport in hepatocytes.","publication_date":"1999,,","publication_name":"Atherosclerosis","grobid_abstract_attachment_id":"46985677"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [50697757]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":46985677,"attachmentType":"pdf"}"><img alt="First page of “Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/46985677/mini_magick20190208-16001-r4wu2n.png?1549625140" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="50697757" href="https://u-psud.academia.edu/NatalieFournier"><img alt="Profile image of Natalie Fournier" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Natalie Fournier</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1999, Atherosclerosis</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">9 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 26703937; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=26703937"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Human lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of cholesterol and is postulated to participate in the physiological process called reverse cholesterol transport. We have used transgenic mice (Tgm) expressing either both human apolipoprotein AI (apo AI) and human LCAT genes or only the human apo AI gene (HuAILCAT or HuAI Tgm, respectively) to assess the consequences of LCAT overexpression on serum lipid and lipoprotein profiles and on the ability of each serum to promote bidirectional flux of cholesterol between serum and Fu5AH hepatoma cells. Mean serum LCAT activity of HuAILCAT Tgm was 2-fold increased compared to the HuAI group (48 9 9 vs. 24 9 5 nmol/ml per h, PB 0.01 for HuAILCAT and HuAI Tgm, respectively) and the cholesterol esterification rates were not significantly different between the two groups of animals (66911 vs. 74918 nmol/ml per h for HuAILCAT and HuAI Tgm, respectively). HuAILCAT Tgm exhibited higher total cholesterol serum values (2.3-fold) due to an increase in both HDL-cholesterol (1.9-fold) and non-HDL-cholesterol (3-fold). The HDL particles from HuAILCAT Tgm were relatively phospholipid depleted and cholesterol enriched compared to HuAI mice. When cells were incubated for six hours with the mouse serum, the fractional efflux of radiolabeled cholesterol was slightly increased with the HuAILCAT Tgm (1.2-fold) but the increase in intracellular cholesterol content was also 2-fold higher than with the HuAI Tgm. Fu5AH can be viewed as a model for the evaluation of bidirectional flux of cholesterol in SR-BI-rich cells. In this model LCAT overexpression in mice, by increasing both HDL and non-HDL-cholesterol, mostly enhances the uptake of cholesterol by the cells, which would be of benefit for the last step of reverse cholesterol transport in hepatocytes.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":46985677,"attachmentType":"pdf","workUrl":"https://www.academia.edu/26703937/Fractional_efflux_and_net_change_in_cellular_cholesterol_content_mediated_by_sera_from_mice_expressing_both_human_apolipoprotein_AI_and_human_lecithin_cholesterol_acyltransferase_genes"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":46985677,"attachmentType":"pdf","workUrl":"https://www.academia.edu/26703937/Fractional_efflux_and_net_change_in_cellular_cholesterol_content_mediated_by_sera_from_mice_expressing_both_human_apolipoprotein_AI_and_human_lecithin_cholesterol_acyltransferase_genes"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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In order to examine the biochemical mechanisms underlying those in ViVo observations, we have compared in Vitro properties of serum from the different groups of animals for participation in cholesterol efflux, LCAT activation, and pre-particle formation. Analysis of cholesterol efflux from both Fu5AH hepatoma and Ob1771 adipose cells revealed serum from the TgAI to be the most efficient in promoting efflux. The two-dimensional electrophoresis of mouse serum shows that control mice have exclusively apoAI in R particles. TgAI and TgAI:AII mice have 30 and 38% of total apoAI in particles with pre-electrophoretic mobility, respectively. The distribution of cell-derived cholesterol between these apoAI-containing lipoprotein subspecies after 1 and 60 min of incubation with Fu5AH hepatoma cells was examined. This revealed after a 1 min incubation 66 ( 8 and 83 ( 9% of the counts in particles with pre-mobility for TgAI and TgAI:AII mice, respectively; while after 60 min of incubation, only 6 ( 2% of counts remained in pre-particles from the TgAI and 30 ( 3% for the TgAI:AII. This suggests faster movement of cholesterol from pre-to R particles in plasma from the TgAI. Consistent with this is the observation that LCAT activity with both exogenous and endogenous substrate increased in the TgAI versus the TgAI:AII mice. The previously observed decrease in fatty streak formation in the TgAI versus the TgAI:AII and control mice is consistent with the in Vitro studies presented here and suggests that HDL containing human apoAI is a more effective participant in the postulated early steps in reverse cholesterol transport than HDL containing both human apoAI and human apoAII, and/or murine HDL.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cholesterol Efflux, Lecithin−Cholesterol Acyltransferase Activity, and Pre-β Particle Formation by Serum from Human Apolipoprotein A-I and Apolipoprotein A-I/Apolipoprotein A-II Transgenic Mice Consistent with the Latter Being Less Effective for Reverse Cholesterol Transport †","attachmentId":47268409,"attachmentType":"pdf","work_url":"https://www.academia.edu/27008300/Cholesterol_Efflux_Lecithin_Cholesterol_Acyltransferase_Activity_and_Pre_%CE%B2_Particle_Formation_by_Serum_from_Human_Apolipoprotein_A_I_and_Apolipoprotein_A_I_Apolipoprotein_A_II_Transgenic_Mice_Consistent_with_the_Latter_Being_Less_Effective_for_Reverse_Cholesterol_Transport_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27008300/Cholesterol_Efflux_Lecithin_Cholesterol_Acyltransferase_Activity_and_Pre_%CE%B2_Particle_Formation_by_Serum_from_Human_Apolipoprotein_A_I_and_Apolipoprotein_A_I_Apolipoprotein_A_II_Transgenic_Mice_Consistent_with_the_Latter_Being_Less_Effective_for_Reverse_Cholesterol_Transport_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="3582027" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/3582027/Effect_of_Up_regulating_Individual_Steps_in_the_Reverse_Cholesterol_Transport_Pathway_on_Reverse_Cholesterol_Transport_in_Normolipidemic_Mice">Effect of Up-regulating Individual Steps in the Reverse Cholesterol Transport Pathway on Reverse Cholesterol Transport in Normolipidemic Mice</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4272047" href="https://independent.academia.edu/KhurshidAlam4">Khurshid Alam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">Cholesterol acquired by extrahepatic tissues (from de novo synthesis or lipoproteins) is returned to the liver for excretion in a process called reverse cholesterol transport (RCT). We undertook studies to determine if RCT could be enhanced by up-regulating individual steps in the RCT pathway. Overexpression of 7␣-hydroxylase, Scavenger receptor B1, lecithin:cholesterol acyltransferase (LCAT), or apoA-I in the liver did not stimulate cholesterol efflux from any extrahepatic tissue. In contrast, infusion of apoA-I⅐phospholipid complexes (rHDL) that resemble nascent HDL markedly stimulated cholesterol efflux from tissues into plasma. Cholesterol effluxed to rHDL was initially unesterified but by 24 h this cholesterol was largely esterified and had shifted to normal HDL (in mice lacking cholesteryl ester transfer protein) or to apoB containing lipoproteins (in cholesteryl ester transfer protein transgenic mice). Most of the cholesterol effluxed into plasma in response to rHDL came from the liver. However, an even greater proportion of effluxed cholesterol was cleared by the liver resulting in a transient increase in liver cholesterol concentrations. Fecal sterol excretion was not increased by rHDL. Thus, although rHDL stimulated cholesterol efflux from most tissues and increased net cholesterol movement from extrahepatic tissues to the liver, cholesterol flux through the entire RCT pathway was not increased.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Up-regulating Individual Steps in the Reverse Cholesterol Transport Pathway on Reverse Cholesterol Transport in Normolipidemic Mice","attachmentId":50218521,"attachmentType":"pdf","work_url":"https://www.academia.edu/3582027/Effect_of_Up_regulating_Individual_Steps_in_the_Reverse_Cholesterol_Transport_Pathway_on_Reverse_Cholesterol_Transport_in_Normolipidemic_Mice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/3582027/Effect_of_Up_regulating_Individual_Steps_in_the_Reverse_Cholesterol_Transport_Pathway_on_Reverse_Cholesterol_Transport_in_Normolipidemic_Mice"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="31287746" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31287746/The_bidirectional_flux_of_cholesterol_between_cells_and_lipoproteins_Effects_of_phospholipid_depletion_of_high_density_lipoprotein">The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32470867" href="https://usuhs.academia.edu/PaulRapp">Paul Rapp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry</p><p class="ds-related-work--abstract ds2-5-body-sm">The bidirectional surface transfer of free cholesterol (FC) between Fu5AH rat hepatoma cells and human high density lipoprotein (HDL) was studied. Cells and HDL were prelabeled with [4-14C]FC and [7-3H]FC, respectively. Influx and efflux of FC were measured simultaneously from the appearance of 3H counts in cells and 14C counts in medium. Results were analyzed by a computerized procedure which fitted sets of kinetic data to a model assuming that cell and HDL FC populations each formed a single homogeneous pool and that together the pools formed a closed system. This analysis yielded values for the first-order rate constants of FC influx and efflux (ki and k.), from which influx and efflux of FC mass (Fi and F,) could be calculated. With normal HDL, the uptake and release of FC tracers conformed well to the above-described model; Fi and F, were approximately equal, suggesting an exchange of FC between cells and HDL. HDL was depleted of phospholipid (PL) by treatment with either phospholipase A2 or heparin-releasable rat hepatic lipase, followed by incubation with bovine serum albumin. PL depletion of HDL had little or no effect on ki, but reduced k,, indicating that PL-deficient HDL is a relatively poor acceptor of cell cholesterol. The reduction in k, resulted in initial Fi > F. and, thus, in net uptake of FC by the cells. This result explained previous results demonstrating net uptake of FC from PL-depleted HDL. In the presence of an inhibitor of acyl coenzyme Axholesterol acyltransferase, the steady state distribution of FC mass between cells and HDL was accurately predicted by the ratio of rate constants for FC flux. This result provided additional validation for describing FC flux in terms of first-order rate constants and homogeneous cell and HDL FC pools.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein","attachmentId":51686867,"attachmentType":"pdf","work_url":"https://www.academia.edu/31287746/The_bidirectional_flux_of_cholesterol_between_cells_and_lipoproteins_Effects_of_phospholipid_depletion_of_high_density_lipoprotein","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31287746/The_bidirectional_flux_of_cholesterol_between_cells_and_lipoproteins_Effects_of_phospholipid_depletion_of_high_density_lipoprotein"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="66045367" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/66045367/Cholesterol_efflux_from_cells_to_immunopurified_subfractions_of_human_high_density_lipoprotein_LP_AI_and_LP_AI_AII">Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45234665" href="https://erasmusmc.academia.edu/ArieVanTol">Arie Van Tol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of lipid …, 1991</p><p class="ds-related-work--abstract ds2-5-body-sm">Using immunoaffinity chromatography, we sepa-cells, there is little or no oxidative degradation of rated human high density lipoprotein (HDL) into two subfrac-cholesterol, and sterol homeostasis requires that excess tions: LP-AI, in which all particles contain apolipoprotein A-I cholestero~ be removed and transported to the liver. These (apoA-I) but no apoA-11, and LP-AI/AII, in which all particles removal and transport processes collectively are termed contain both apoA-I and apoA-11. To compare LP-AI and LP-AI/AII as acceptors of cell cholesterol, the isolated subfractions reverse cholesterol transport, and are mediated plasma were diluted to 50 pg phospholipid/ml, and then incubated with lipoproteins (reviewed in ref. 2). The initial removal of monolayer cultures of cells in which whole-cell and lysosomal sterol from cells involves the transfer of cholesterol from ~.~~ cholesterol has been labeled with '*c and 3H, respectively. w e used three cell types (Fu5AH rat hepatoma cells, normal human skin fibroblasts, and rabbit aortic smooth muscle cells). When these cells were DreDared to contain normal Dhvsiolocical auan-Abbreviations: HDL, high density lipoprotein; LDL, low density Supplementary key words hepatoma cells fibroblasts smooth lipoprotein; r[SH-COILDL, low density lipoprotein reconstituted with muscle cells apolipoprotein A-I apolipoprotein A-I1 plasma [3H]cholesteryl oleate; apoA-I, apolipoprotein A-I; LP-AI, immembrane lysosomes low density lipoprotein munopurified HDL fraction containing apoA-I, but no apoA-11; LP-AI/AII, immunopurified HDL fraction containing both apoA-I and apoA-11; HEPES, N-Z-hydroxyethylpiperazine-N'-Z-ethanesulfonic acid; BSA, bovine serum albumin; FC, free (unesterified) cholesterol; The major portion of cholesterol in nucleated cells of MEM, Eagle's minimum essential medium; ACAT, acyl-coenzyme mammals is found in the plasma membrane, although A:cholesterol acyltransferase; LCAT, 1ecithin:cholesterol acyltransferase.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII","attachmentId":77390125,"attachmentType":"pdf","work_url":"https://www.academia.edu/66045367/Cholesterol_efflux_from_cells_to_immunopurified_subfractions_of_human_high_density_lipoprotein_LP_AI_and_LP_AI_AII","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/66045367/Cholesterol_efflux_from_cells_to_immunopurified_subfractions_of_human_high_density_lipoprotein_LP_AI_and_LP_AI_AII"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="85617604" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85617604/Regulation_of_Cellular_Cholesterol_Efflux_by_Lecithin_Cholesterol_Acyltransferase_Reaction_through_Nonspecific_Lipid_Exchange">Regulation of Cellular Cholesterol Efflux by Lecithin:Cholesterol Acyltransferase Reaction through Nonspecific Lipid Exchange</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217294013" href="https://independent.academia.edu/HelenaPrusCzarnecka">Helena Prus - Czarnecka</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Regulation of Cellular Cholesterol Efflux by Lecithin:Cholesterol Acyltransferase Reaction through Nonspecific Lipid Exchange","attachmentId":90259661,"attachmentType":"pdf","work_url":"https://www.academia.edu/85617604/Regulation_of_Cellular_Cholesterol_Efflux_by_Lecithin_Cholesterol_Acyltransferase_Reaction_through_Nonspecific_Lipid_Exchange","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85617604/Regulation_of_Cellular_Cholesterol_Efflux_by_Lecithin_Cholesterol_Acyltransferase_Reaction_through_Nonspecific_Lipid_Exchange"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="21458831" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21458831/Role_of_HDL_phospholipid_in_efflux_of_cell_cholesterol_to_whole_serum_studies_with_human_apoA_I_transgenic_rats">Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42535572" href="https://independent.academia.edu/NFournier1">N. Fournier</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of lipid research, 1996</p><p class="ds-related-work--abstract ds2-5-body-sm">Sera of transgenic rats expressing human apoA-I were tested for their ability to stimulate efflux of radiolabeled cholesterol from Fu5AH rat hepatoma cells. Expression of human apoA-I resulted in a dose-dependent increase in HDL, as measured by both HDL-cholesterol and HDL-phospholipid, and produced a decrease in rat apoA-I. In rats expressing high concentrations of human apoA-I (TgR[hAI]high, human apoA-I &gt; 250 mg/dl), the increase in HDL-phospholipid was not proportional to the increase in human apoA-I, as illustrated by a HDL-PL/total apoA-I ratio of 0.84 +/- 0.19 compared to a ratio of 1.28 +/- 0.29 for control rats and of 1.28 +/- 0.39 for rats expressing low levels of human apoA-I (TgR[hAI]low, human apoA-I &lt; 250 mg/dl). Compared to sera from control animals, efflux of cell cholesterol was increased by 26% in the sera from TgR[hAI]low, and by 76% in the TgR[hAI]high. An examination of the relationships between efflux and HDL-related parameters demonstrated a hyperbolic r...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats","attachmentId":41888662,"attachmentType":"pdf","work_url":"https://www.academia.edu/21458831/Role_of_HDL_phospholipid_in_efflux_of_cell_cholesterol_to_whole_serum_studies_with_human_apoA_I_transgenic_rats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21458831/Role_of_HDL_phospholipid_in_efflux_of_cell_cholesterol_to_whole_serum_studies_with_human_apoA_I_transgenic_rats"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="27605855" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27605855/In_vitro_and_in_vivo_evidence_for_the_role_of_HDL_in_reverse_cholesterol_transport">In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51754001" href="https://leidenuniv.academia.edu/TheoVanBerkel">Theo Van Berkel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport","attachmentId":47870381,"attachmentType":"pdf","work_url":"https://www.academia.edu/27605855/In_vitro_and_in_vivo_evidence_for_the_role_of_HDL_in_reverse_cholesterol_transport","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27605855/In_vitro_and_in_vivo_evidence_for_the_role_of_HDL_in_reverse_cholesterol_transport"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="21877948" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21877948/Study_of_the_components_of_reverse_cholesterol_transport_in_lecithin_Cholesterol_acyltransferase_deficiency">Study of the components of reverse cholesterol transport in lecithin: Cholesterol acyltransferase deficiency</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43114356" href="https://unthsc.academia.edu/AndrasLacko">Andras Lacko</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Biochemistry and Biophysics, 1987</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Study of the components of reverse cholesterol transport in lecithin: Cholesterol acyltransferase deficiency","attachmentId":42616446,"attachmentType":"pdf","work_url":"https://www.academia.edu/21877948/Study_of_the_components_of_reverse_cholesterol_transport_in_lecithin_Cholesterol_acyltransferase_deficiency","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21877948/Study_of_the_components_of_reverse_cholesterol_transport_in_lecithin_Cholesterol_acyltransferase_deficiency"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="21999182" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21999182/International_Symposium_on_Reverse_Cholesterol_Transport_Report_on_a_meeting">International Symposium on Reverse Cholesterol Transport. Report on a meeting</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43114356" href="https://unthsc.academia.edu/AndrasLacko">Andras Lacko</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of lipid research, 1990</p><p class="ds-related-work--abstract ds2-5-body-sm">The purpose of this symposium was to provide a forum for the reporting of recent findings and the exchange of ideas concerning reverse cholesterol transport, an area of intense interest and some controversy. Data from epidemiological studies have consistently shown that elevated levels of high density lipoproteins (HDL) are an index of increased protection against coronary heart disease. However, the mechanism whereby HDL is involved in the prevention and/or reversal of atherosclerosis is unknown. According to one of the hypotheses, HDL acts as the primary acceptor of unesterified cholesterol from cells and functions jointly with the enzyme lecithin:cholesterol acyltransferase (LCAT) and the cholesteryl ester transfer protein (CETP) to facilitate the movement of cholesterol from peripheral tissues to the plasma and ultimately to the liver. Although this mechanism as originally proposed by Glomset is an essential physiological mechanism, the clinical significance of this hypothesis r...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"International Symposium on Reverse Cholesterol Transport. Report on a meeting","attachmentId":42702511,"attachmentType":"pdf","work_url":"https://www.academia.edu/21999182/International_Symposium_on_Reverse_Cholesterol_Transport_Report_on_a_meeting","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21999182/International_Symposium_on_Reverse_Cholesterol_Transport_Report_on_a_meeting"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="89463963" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89463963/Lecithin_Cholesterol_Acyltransferase_Overexpression_Generates_Hyperalpha_lipoproteinemia_and_a_Nonatherogenic_Lipoprotein_Pattern_in_Transgenic_Rabbits">Lecithin:Cholesterol Acyltransferase Overexpression Generates Hyperalpha-lipoproteinemia and a Nonatherogenic Lipoprotein Pattern in Transgenic Rabbits</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37348702" href="https://virginia.academia.edu/SanfordFeldman">Sanford H Feldman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1996</p><p class="ds-related-work--abstract ds2-5-body-sm">Cholesterol esterification within plasma lipoprotein particles is catalyzed by lecithin:cholesterol acyltransferase (LCAT). The impact of the overexpression of this enzyme on plasma concentrations of the different plasma lipoproteins in an animal model expressing cholesteryl ester transfer protein was evaluated by generating rabbits expressing human LCAT. A 6.2-kilobase human genomic DNA construct was injected into the pronuclei of rabbit embryos. Of the 1002 embryos that were injected, 3 founder rabbits were characterized that expressed the human LCAT gene. As in mice and humans, the principal sites of mRNA expression in these rabbits is in the liver and brain, indicating that the regulatory elements required for tissue-specific expression among these species are similar. The ␣-LCAT activity correlated with the number of copies of LCAT that integrated into the rabbit DNA. Compared with controls, the high expressor LCAT-transgenic rabbits total and high density lipoprotein (HDL) cholesterol concentrations were increased 1.5-2.5-fold with a 3.1-fold increase in the plasma cholesterol esterification rate. Analysis of the plasma lipoproteins by fast protein liquid chromatography indicates that these changes reflected an increased concentration of apolipoprotein Eenriched, HDL 1-sized particles, whereas atherogenic apolipoprotein B particles disappeared from the plasma. The concentrations of plasma HDL cholesterol were highly correlated with both human LCAT mass (r ‫؍‬ 0.93; p ‫؍‬ 0.001) and the log LCAT activity (r ‫؍‬ 0.94; p < 0.001) in the transgenic rabbits. These results indicate that overexpression of LCAT in the presence of cholesteryl ester transfer protein leads to both hyperalphalipoproteinemia and reduced concentrations of atherogenic lipoproteins.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lecithin:Cholesterol Acyltransferase Overexpression Generates Hyperalpha-lipoproteinemia and a Nonatherogenic Lipoprotein Pattern in Transgenic Rabbits","attachmentId":93265583,"attachmentType":"pdf","work_url":"https://www.academia.edu/89463963/Lecithin_Cholesterol_Acyltransferase_Overexpression_Generates_Hyperalpha_lipoproteinemia_and_a_Nonatherogenic_Lipoprotein_Pattern_in_Transgenic_Rabbits","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/89463963/Lecithin_Cholesterol_Acyltransferase_Overexpression_Generates_Hyperalpha_lipoproteinemia_and_a_Nonatherogenic_Lipoprotein_Pattern_in_Transgenic_Rabbits"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":46985677,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":46985677,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_46985677" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="93184303" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93184303/Evidence_for_reverse_cholesterol_transport_in_vivo_from_liver_endothelial_cells_to_parenchymal_cells_and_bile_by_high_density_lipoprotein">Evidence for reverse cholesterol transport in vivo from liver endothelial cells to parenchymal cells and bile by high-density lipoprotein</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51754001" href="https://leidenuniv.academia.edu/TheoVanBerkel">Theo 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href="https://www.academia.edu/93184303/Evidence_for_reverse_cholesterol_transport_in_vivo_from_liver_endothelial_cells_to_parenchymal_cells_and_bile_by_high_density_lipoprotein"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="113103045" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/113103045/Hepatobiliary_cholesterol_transport_is_not_impaired_in_Abca1_null_mice_lacking_HDL">Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33232520" href="https://umcg.academia.edu/FolkertKuipers">Folkert Kuipers</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Investigation, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL","attachmentId":110151886,"attachmentType":"pdf","work_url":"https://www.academia.edu/113103045/Hepatobiliary_cholesterol_transport_is_not_impaired_in_Abca1_null_mice_lacking_HDL","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/113103045/Hepatobiliary_cholesterol_transport_is_not_impaired_in_Abca1_null_mice_lacking_HDL"><span 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class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of different cellular models measuring in vitro the whole human serum cholesterol efflux capacity","attachmentId":46985666,"attachmentType":"pdf","work_url":"https://www.academia.edu/26703944/Comparison_of_different_cellular_models_measuring_in_vitro_the_whole_human_serum_cholesterol_efflux_capacity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/26703944/Comparison_of_different_cellular_models_measuring_in_vitro_the_whole_human_serum_cholesterol_efflux_capacity"><span class="ds2-5-text-link__content">View PDF</span><span 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data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26728328/Reactivity_of_HDL_subfractions_towards_lecithin_cholesterol_acyltransferase_Modulation_by_their_content_in_free_cholesterol">Reactivity of HDL subfractions towards lecithin-cholesterol acyltransferase. Modulation by their content in free cholesterol</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50672584" href="https://independent.academia.edu/BertrandPerret">Bertrand Perret</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactivity of HDL subfractions towards lecithin-cholesterol acyltransferase. Modulation by their content in free cholesterol","attachmentId":47008051,"attachmentType":"pdf","work_url":"https://www.academia.edu/26728328/Reactivity_of_HDL_subfractions_towards_lecithin_cholesterol_acyltransferase_Modulation_by_their_content_in_free_cholesterol","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/26728328/Reactivity_of_HDL_subfractions_towards_lecithin_cholesterol_acyltransferase_Modulation_by_their_content_in_free_cholesterol"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="38145001" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/38145001/Different_cellular_traffic_of_LDL_cholesterol_and_acetylated_LDL_cholesterol_leads_to_distinct_reverse_cholesterol_transport_pathways">Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6234572" href="https://vmmuzeum.academia.edu/R%C3%B3bertKiss">Róbert Kiss</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Lipid Research, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways","attachmentId":58179942,"attachmentType":"pdf","work_url":"https://www.academia.edu/38145001/Different_cellular_traffic_of_LDL_cholesterol_and_acetylated_LDL_cholesterol_leads_to_distinct_reverse_cholesterol_transport_pathways","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/38145001/Different_cellular_traffic_of_LDL_cholesterol_and_acetylated_LDL_cholesterol_leads_to_distinct_reverse_cholesterol_transport_pathways"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="14205877" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14205877/Hepatobiliary_cholesterol_transport_is_not_impaired_in_ABCA1_null_mice">Hepatobiliary cholesterol transport is not impaired in ABCA1 null mice</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33192427" href="https://independent.academia.edu/AlbertGroen">Albert Groen</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33232520" href="https://umcg.academia.edu/FolkertKuipers">Folkert Kuipers</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gastroenterology, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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data-entity-id="123995661" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123995661/Trans_intestinal_cholesterol_efflux_is_not_mediated_through_high_density_lipoprotein">Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41461685" href="https://independent.academia.edu/KarinvanDenOever">Karin van Den Oever</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Lipid Research, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Trans-intestinal cholesterol efflux is not mediated through high density 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ds2-5-body-link" href="https://www.academia.edu/10140149/Impact_of_high_cholesterol_intake_on_tissue_cholesterol_content_and_lipid_transfers_to_high_density_lipoprotein">Impact of high cholesterol intake on tissue cholesterol content and lipid transfers to high-density lipoprotein</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="24754591" href="https://independent.academia.edu/tatianeoliveira16">tatiane oliveira</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nutrition, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Impact of high cholesterol intake on tissue cholesterol content and lipid transfers to high-density 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Poledne</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Physiological research / Academia Scientiarum Bohemoslovaca, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reverse transport of cholesterol is the reason for resistance to development of atherosclerosis in Prague Hereditary Hypercholesterolemic (PHHC) rat","attachmentId":79992714,"attachmentType":"pdf","work_url":"https://www.academia.edu/70133579/Reverse_transport_of_cholesterol_is_the_reason_for_resistance_to_development_of_atherosclerosis_in_Prague_Hereditary_Hypercholesterolemic_PHHC_rat","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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href="https://www.academia.edu/70176049/In_vivo_tissue_cholesterol_efflux_is_reduced_in_carriers_of_a_mutation_in_APOA1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="16026455" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16026455/Impaired_capacity_of_acute_phase_high_density_lipoprotein_particles_to_deliver_cholesteryl_ester_to_the_human_HUH_7_hepatoma_cell_line">Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35166959" href="https://independent.academia.edu/PPussinen">P Pussinen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The International Journal of Biochemistry & Cell Biology, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line","attachmentId":42781197,"attachmentType":"pdf","work_url":"https://www.academia.edu/16026455/Impaired_capacity_of_acute_phase_high_density_lipoprotein_particles_to_deliver_cholesteryl_ester_to_the_human_HUH_7_hepatoma_cell_line","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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