Virology Institute | Gladstone Institutes

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<header class="node__header"> </header> <div id="intro"> <div class="container"> <nav role="navigation" aria-labelledby="block-institutetabs-menu" id="block-institutetabs" class="clearfix block block-menu navigation menu--institute-tabs"> <h2 class="visually-hidden" id="block-institutetabs-menu">Institute tabs</h2> <ul class="clearfix menu"> <li class="menu-item"> <a href="/science/institutes" data-drupal-link-system-path="node/2535">Overview</a> </li> <li class="menu-item"> <a href="/science/cardiovascular-disease-institute" data-drupal-link-system-path="node/2510">Cardiovascular Disease</a> </li> <li class="menu-item"> <a href="/science/data-science-and-biotechnology-institute" data-drupal-link-system-path="node/2513">Data Science & Biotechnology</a> </li> <li class="menu-item"> <a href="/science/genomic-immunology-institute" data-drupal-link-system-path="node/3081">Genomic Immunology</a> </li> <li class="menu-item"> <a href="/science/neurological-disease-institute" data-drupal-link-system-path="node/2512">Neurological Disease</a> </li> <li class="menu-item menu-item--active-trail"> <a href="/science/virology-institute" data-drupal-link-system-path="node/2511" class="is-active" aria-current="page">Virology</a> </li> </ul> </nav> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p class="large">Viruses majorly shape human health, both directly—through infection of human cells—and indirectly—as phages that infect the bacteria of the microbiome.</p> <p class="large">Our researchers study both human viruses and phages and how they manipulate human health and disease. They are generating rapid diagnostics, innovative vaccines and new drugs and immunotherapies against dangerous viral infections. Our scientists are also developing methods to use phages as therapies to treat antibiotic-resistant bacteria and promote healthy microbiomes.</p> <p>Gladstone virologists spearheaded the use of antiretroviral therapy as HIV prophylaxis (PREP). Equipped with two high-security biocontainment labs, Gladstone virologists rapidly responded to COVID-19, developing innovative diagnostic, preventative, and treatment approaches. These include the first host-SARS-CoV-2 interaction map, which identified FDA-approved drugs as potential antiviral treatments, a new “combined” mRNA vaccine with better efficacy, rapid testing devices using CRISPR technology and mobile phones, and virus-like particles that allow scientists to investigate new versions of the virus as they arise.</p> <p>The institute is also the organizational hub for <a href="https://gladstone.org/news/new-approach-curing-hiv" rel="noopener" target="_blank">HOPE, a multinational NIH-sponsored Collaboratory to find a cure for HIV.</a> HOPE scientists aim to convert HIV from a pandemic pathogen into a harmless part of the human genome using advanced epigenetic and gene therapy interventions.</p> <p>Gladstone scientists are dedicated to mentoring the future generation of scientists interested in virology. <a href="https://gladstone.org/training" rel="noopener" target="_blank">Learn more about Gladstone’s training programs.</a></p> </div> </div> </div> <div id="directorquote"> <div class="row"> <div id="directormug"></div> <div class="dquote"> <div class="dquote-text"> <div class="clearfix text-formatted field field--name-field-director-quote-text field--type-text-long field--label-hidden field__item"><p>“Our goal is to discover the most impactful disease mechanisms and translate basic scientific discoveries into better treatments for patients.”</p> </div> <div class="dname"> <div class="field field--name-field-director-name field--type-string field--label-hidden field__item">Melanie Ott, MD, PhD</div> </div> <em> <div class="field field--name-field-director-title field--type-string field--label-hidden field__item">Director, Gladstone Institute of Virology</div> </em> <div id="dirvisbutt">  </div> </div> </div> </div> </div> <div class="accordion-wrapper"> <div class="container"> <h2>Major Scientific Achievements</h2> <div class="accordion accord1"><h3> <div class="field field--name-field-achievement-1-title field--type-string field--label-hidden field__item">Led the Global iPrEX Study, Which Established Pre-Exposure Prophylaxis (PrEP) as an Efficient Way to Prevent New HIV Infections</div> </h3></div> <div class="panel"> <div class="clearfix text-formatted field field--name-field-achievement-1 field--type-text-long field--label-hidden field__item"><p>A Gladstone team demonstrated that two antiretroviral drugs, combined in a single tablet, can be used to prevent HIV infection in high-risk populations, providing proof of concept for pre-exposure prophylaxis. The approach has been adopted in San Francisco and worldwide.</p> </div> </div> <div class="accordion"><h3> <div class="field field--name-field-achievement-2-title field--type-string field--label-hidden field__item">Generated T Cell Lines Mimicking HIV Latency</div> </h3></div> <div class="panel"> <div class="clearfix text-formatted field field--name-field-achievement-2 field--type-text-long field--label-hidden field__item"><p>HIV can hide out quietly in human immune cells for decades, and a true HIV cure will require eradicating or permanently silencing the latent viral reservoir. Gladstone scientists developed cell models of latency that are now widely used for HIV cure research.</p> </div> </div> <div class="accordion"><h3> <div class="field field--name-field-achievement-3-title field--type-string field--label-hidden field__item">Demonstrated That Amyloid Fibrils Found in Semen Enhance Infection by HIV and Other Sexually Transmitted Viruses</div> </h3></div> <div class="panel"> <div class="clearfix text-formatted field field--name-field-achievement-3 field--type-text-long field--label-hidden field__item"><p>Sexual transmission accounts for the vast majority of HIV infections. A Gladstone team discovered that components of semen actually attract the virus and help it infect CD4 T cells. This finding could pave the way for improved microbicides that target the fibrils to protect against sexual transmission.</p> </div> </div> <div class="accordion"><h3> <div class="field field--name-field-achievement-4-title field--type-string field--label-hidden field__item">Provided First Comprehensive Host-Virus Protein Interaction Maps for HIV, Hepatitis C Virus, SARS-CoV-2, and Other Viruses</div> </h3></div> <div class="panel"> <div class="clearfix text-formatted field field--name-field-achievement-4 field--type-text-long field--label-hidden field__item"><p>By identifying the human proteins that are required for viral infection, scientists may be able to develop broad antiviral drugs that target the host proteins commonly used by many viruses. In addition, this approach could help them identify previously approved drugs targeting human proteins that may be repurposed for antiviral therapy.</p> </div> </div> <div class="accordion"><h3> <div class="field field--name-field-achievement-5-title field--type-string field--label-hidden field__item">Identified an Anti-Aging Protein That Could Rejuvenate Immune Cells</div> </h3></div> <div class="panel"> <div class="clearfix text-formatted field field--name-field-achievement-5 field--type-text-long field--label-hidden field__item"><p>Gladstone researchers revealed that a protein called SIRT1, commonly known for being activated by a component of red wine, could also be targeted to rejuvenate cells in the immune system. After identifying the crucial role played by SIRT1 in the aging of immune cells, they identified two potential new treatment targets. First, new drugs could be developed to strengthen SIRT1, which could postpone the development of age-related diseases and help people with a weaker immune system fight infections or better respond to immune vaccination. Second, drugs could be used to obtain the opposite effect on SIRT1 to support an aggressive anti-tumor response or other immune therapeutic approaches.</p> </div> </div> </div> </div> <div id="experts"> <div class="container"> <h2>Virology Experts</h2> <div id="people" class="owl-carousel"> </div> <a name="vision"></a> </div> </div> <div id="dvision"> <div class="container"> <h2 style="color:white;">Director’s Message</h2> </div> </div> <div id="related-news"> <div class="container"> <h2>Related News</h2> <div id="news-carousel" class="owl-carousel"> </div> </div> </div> </div> </div> </article> <style> .big-giant-head { background-image: url('/sites/default/files/background-images/virology-immunology.jpg'); } #directormug { background-image: url('/sites/default/files/background-images/melanieott-crop.jpg'); } </style> <script> var acc = document.getElementsByClassName("accordion"); var i; for (i = 0; i < acc.length; i++) { acc[i].addEventListener("click", function() { this.classList.toggle("active"); 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