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id="header-menu-menu-link-content01012a58-7026-4031-ac0f-ff1c4ebfa2b0" class="sf-depth-4 sf-no-children"><a href="/metabolomics" class="sf-depth-4">Metabolomics</a></li><li id="header-menu-menu-link-contentc47e179f-f657-4d1c-845a-cf4a5ad385ab" class="sf-depth-4 sf-no-children"><a href="/proteomics" class="sf-depth-4">Proteomics</a></li><li id="header-menu-menu-link-content8c052979-e431-4001-a66d-e1c748fcbcfa" class="sf-depth-4 sf-no-children"><a href="/spatial-technology-platform" class="sf-depth-4">Spatial technologies</a></li></ul></li></ol></div></li><li id="header-menu-menu-link-content72a439d6-d068-45b2-91bd-e260d096d7a0" class="sf-depth-2 sf-multicolumn-column menuparent"><div class="sf-multicolumn-column"><span class="hidden sf-depth-2 menuparent nolink">Science</span><ol><li id="header-menu-menu-link-contentcec421e8-e0b3-4987-b4dd-7c19285b27ae" class="sf-depth-3 sf-no-children"><a href="/patient-partnered-research" class="sf-depth-3" title="Patients partner with our scientists to accelerate the pace of discovery and find better treatments.">Patient-partnered research <span class="sf-description">Patients partner with our scientists to accelerate the pace of discovery and find better treatments.</span></a></li><li id="header-menu-menu-link-content93f5c6b6-e25f-4dcf-940d-8cd0ebdaab9a" class="sf-depth-3 sf-no-children"><a href="/strategic-alliances-and-partnering" class="sf-depth-3" title="We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.">Partnering and licensing <span class="sf-description">We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries.</span></a></li><li id="header-menu-menu-link-content40d899bd-29da-4415-816c-0381756261ac" class="sf-depth-3 sf-no-children"><a href="/publications" class="sf-depth-3" title="A catalog of scientific papers published by our members and staff scientists.">Publications <span class="sf-description">A catalog of scientific papers published by our members and staff scientists.</span></a></li><li id="header-menu-menu-link-content34ab328b-68c7-4d06-a9ba-588a6ceee9ba" class="sf-depth-3 sf-no-children"><a href="/resources-services-and-tools" class="sf-depth-3" title="Key scientific datasets and computational tools developed by our scientists and their collaborators.">Resources, services, and tools <span class="sf-description">Key scientific datasets and computational tools developed by our scientists and their collaborators.</span></a></li><li id="header-menu-menu-link-contenta0572cb2-0bde-499b-bec6-b924aa62edfc" class="sf-depth-3 sf-no-children"><a href="/collaborations-and-consortia" class="sf-depth-3" title="We join with institutions and scientists the world over to address foundational challenges in science and health.">Collaborations and consortia <span class="sf-description">We join with institutions and scientists the world over to address foundational challenges in science and health.</span></a></li></ol></div></li></ol></li></ul></li><li id="header-menu-menu-link-content9cc92c89-3ea1-4a3d-b678-15216f32ab77" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Centers</span><ul class="sf-multicolumn"><li class="sf-multicolumn-wrapper "><ol><li id="header-menu-menu-link-content876bc9c1-14fb-46d8-8a3f-cef576f8af99" class="sf-depth-2 sf-no-children"><a href="/sigma" class="sf-depth-2" title="The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.">Carlos Slim Center for Health Research <span class="sf-description">The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.</span></a></li><li id="header-menu-menu-link-content160561bf-c8e9-4bf6-aca8-4d2848930259" class="sf-depth-2 sf-no-children"><a href="/gerstner-center-cancer-diagnostics" class="sf-depth-2" title="The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.">Gerstner Center for Cancer Diagnostics <span class="sf-description">The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.</span></a></li><li id="header-menu-menu-link-contenta1450e5b-1fbb-4d9e-85f7-e0df335ada8c" class="sf-depth-2 sf-no-children"><a href="/klarman-cell-observatory" class="sf-depth-2" title="The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.">Klarman Cell Observatory <span class="sf-description">The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.</span></a></li><li id="header-menu-menu-link-contentf919ca42-db45-41ce-8888-efe027a9fb36" class="sf-depth-2 sf-no-children"><a href="/merkin-institute-transformative-technologies-healthcare" class="sf-depth-2" title="The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.">Merkin Institute for Transformative Technologies in Healthcare <span class="sf-description">The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.</span></a></li><li id="header-menu-menu-link-contentb12c2ad1-a84c-455a-821e-59bfd482c758" class="sf-depth-2 sf-no-children"><a href="/nnfc" class="sf-depth-2" title="This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.">Novo Nordisk Foundation Center for Genomic Mechanisms of Disease <span class="sf-description">This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.</span></a></li><li id="header-menu-menu-link-content317da4e7-16de-4bbc-95da-f3ea10e0c178" class="sf-depth-2 sf-no-children"><a href="/ewsc" class="sf-depth-2" title="The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.">Eric and Wendy Schmidt Center <span class="sf-description">The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.</span></a></li><li id="header-menu-menu-link-content13d4c1b3-4076-45da-bf73-8a5d2c08222e" class="sf-depth-2 sf-no-children"><a 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field__item"> <a href="https://www.broadinstitute.org/news/researchers-identify-source-brain-cancers-deadly-transformation"><picture> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_desktop_xl/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=0S9VBVhD 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="360" height="440"/> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_desktop_xl/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=0S9VBVhD 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="360" height="440"/> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_desktop/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=ov9aRGNd 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="354" height="433"/> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_laptop/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=jl3uiYZP 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/jpeg" width="280" height="342"/> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_tablet/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=UarnlfxR 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/jpeg" width="340" height="273"/> <source srcset="/files/styles/multiple_ct_teaser_latest_bottom_phone/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=Tjlpw30y 1x" media="all and (max-width: 539px)" type="image/jpeg" width="499" height="399"/> <img loading="eager" src="/files/styles/multiple_ct_teaser_latest_bottom_phone/public/longstory/32446414167_c546eaaeb3_k%20%281%29.jpg?h=bce46435&itok=Tjlpw30y" width="499" height="399" alt="Microscopy image shows glioma tumor cells in blue and pink." title="Microscopy image shows glioma tumor cells in blue and pink." typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="teaser-news__main-content"> <div class="teaser-news__main"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/researchers-identify-source-brain-cancers-deadly-transformation">News 11.21.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/researchers-identify-source-brain-cancers-deadly-transformation" hreflang="en">Researchers identify source of a brain cancer鈥檚 deadly transformation</a></span> </div> </div> </div> </div> </div> </article> </div> <div class="views-row"> <article about="/news/scientists-find-region-mouse-gut-tightly-regulated-immune-system" class="node node--type-long-story 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