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Stanley Center for Psychiatric Research | Broad Institute

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We study genetics and biology of psychiatric disorders, neurological conditions: schizophrenia, bipolar disorder, autism, Alzheimer鈥檚, Huntington&#039;s, ADHD." /> <link rel="canonical" href="https://www.broadinstitute.org/stanley-center-for-psychiatric-research" /> <link rel="shortlink" href="https://www.broadinstitute.org/node/8513" /> <link rel="image_src" href="https://www.broadinstitute.org/files/StanleyCenter-logo-space-4.png" /> <meta property="og:site_name" content="@broadinstitute" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.broadinstitute.org/stanley-center-for-psychiatric-research" /> <meta property="og:title" content="Stanley Center for Psychiatric Research" /> <meta property="og:description" content="The mission of the Stanley Center for Psychiatric Research at Broad Institute is to reduce the burden of serious mental illness through research. Using our ongoing discoveries of genetic variants associated with disease as a launch point, we are contributing to new understandings of pathogenic disease mechanisms, the identification of disease biomarkers, and above all, new treatments.聽" /> <meta property="og:image" content="https://www.broadinstitute.org/files/StanleyCenter-logo-space-4.png" /> <meta property="og:image:url" content="https://www.broadinstitute.org/files/StanleyCenter-logo-space-4.png" /> <meta property="og:image:secure_url" content="https://www.broadinstitute.org/files/StanleyCenter-logo-space-4.png" /> <meta property="og:updated_time" content="2025-02-18T12:56:44-05:00" /> <meta property="article:published_time" content="2015-12-18T10:48:49-05:00" /> <meta property="article:modified_time" content="2015-12-18T10:48:49-05:00" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:description" content="The mission of the Stanley Center for Psychiatric Research at Broad Institute is to reduce the burden of serious mental illness through research. 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class="node__content"> <div class="hero-section container"> <div class="hero-section__row row"> <div class="hero-section__content hero-section__content_left col-6"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/centers">Centers</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Stanley Center for Psychiatric Research</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p dir="ltr">The mission of the Stanley Center for Psychiatric Research at Broad Institute is to reduce the burden of serious mental illness through research. Using our ongoing discoveries of genetic variants associated with disease as a launch point, we are contributing to new understandings of pathogenic disease mechanisms, the identification of disease biomarkers, and above all, new treatments.</p> </div> </div> </div> </div> <div class="hero-section__right col-6"> <div class="hero-section__image"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-image"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"> <article class="media media--type-image media--view-mode-multiple-content-types-header"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=T9ewObO7 1x" media="all and (min-width: 1921px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop_xl/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=T9ewObO7 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="754" height="503"/> <source srcset="/files/styles/multiple_ct_header_desktop/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=41oYU9pV 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="736" height="520"/> <source srcset="/files/styles/multiple_ct_header_laptop/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=jf4ywmqI 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="641" height="451"/> <source srcset="/files/styles/multiple_ct_header_tablet/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=8bERd60j 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="706" height="417"/> <source srcset="/files/styles/multiple_ct_header_phone/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=LC7O6NhS 1x" media="all and (max-width: 539px)" type="image/png" width="499" height="294"/> <img loading="eager" width="499" height="294" src="/files/styles/multiple_ct_header_phone/public/StanleyCenter-logo-space-4.png?h=27d9a407&amp;itok=LC7O6NhS" alt="Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard" title="Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard" typeof="foaf:Image" /> </picture> </div> <div class="media-caption"> <div class="media-caption__description"> </div> </div> </article> </div> </div> </div> </div> </div> </div> <div class="content-section content-section_with-sidebars container"> <div class="row"> <div class="content-section__main col-8 offset-2"> <div class="block block-layout-builder block-field-blocknodelanding-pagebody"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Stanley Center <a href="/node/1282356">Scientific Investigators</a> are successfully working on these issues in highly collaborative teams to significantly advance our knowledge of psychiatric disease and the development of treatments. Additionally, the Stanley Center launched the Stanley Global &nbsp;Neuropsychiatric Genetics Initiative (<a href="/node/145111">Stanley Global</a>) in 2014, collaborating with research groups around the world to expand genetic sample collection across diverse worldwide populations.</p> <p>Find out more about our areas of focus:</p> <ol dir="ltr"> <li><a href="/node/139616">Human genetics initiatives</a></li> <li><a href="/node/129801">Neurobiology initiatives</a></li> <li><a href="/node/85871">Therapeutics and biomarker discovery</a></li> </ol> <p dir="ltr">&nbsp;</p> <p dir="ltr">Through research at the Broad Institute and partnerships with collaborators worldwide, scientists at the Stanley Center aim to understand the biology of schizophrenia and bipolar disorder and to develop diagnostics and treatments to help people with these disorders. Our research also informs our broader understanding of mental illness, neurodevelopmental conditions (such as ADHD and autism spectrum disorders), and neurodegenerative disorders (such as Alzheimer's and Parkinson's), nicely bridging with work going on across the <a href="https://www.broadinstitute.org/brain-health">Program in Brain Health</a> at Broad.</p> <p> <a href="/node/8458"><strong>Click here to read the Stanley Center's Commitment to Genomic Data Sharing</strong></a><br> &nbsp;</p> <p>Philanthropists Ted and Vada Stanley enabled this groundbreaking research. In 2014, Stanley announced an <a href="https://www.broadinstitute.org/blog/broad-news-ted-stanley%E2%80%99s-extraordinary-commitment-psychiatric-research">unprecedented commitment of $650 million</a> aimed at galvanizing scientific research on psychiatric disorders and bringing new treatments based on a molecular understanding. In total, the Stanley Family Foundation鈥檚 support of the Stanley Center totals $860 million, representing the largest philanthropic commitment ever in psychiatric research.</p> <p>The Stanley Center has also received generous support from other committed philanthropists and foundations. Philanthropy is critical to advancing our mission鈥攑lease email Priya McCue at <a href="mailto:pmccue@broadinstitute.org">pmccue@broadinstitute.org</a> if you are interested in supporting our efforts to uncover the biological roots of severe psychiatric disease and ultimately find new treatments. &nbsp;</p> </div> </div> </div> <div class="content-section__right col-2"> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Stanley Center</h2> <ul class="menu"> <li class="menu-item"> <a href="/stanley-center-for-psychiatric-research" data-drupal-link-system-path="node/8513" class="is-active" aria-current="page">About</a> </li> <li class="menu-item"> <a href="/stanley-center-psychiatric-research-history" title="Stanley Center History" data-drupal-link-system-path="node/1282831">History</a> </li> <li class="menu-item"> <a href="/stanley-center-psychiatric-research/stanley-center-governing-committees" data-drupal-link-system-path="node/2607">Governing 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class="views-element-container block block-views block-views-blockrelated-publications-list-more-link"> <div class="publications-list-wrapper"> <div class="publications-list-wrapper__title"> <h2>Recent publications</h2> <div class="more-link"> <a href="/publications-list/598">Other Stanley Center for Psychiatric Research publications</a> </div> </div> <div><div class="view view-related-publications view-id-related_publications view-display-id-list_more_link js-view-dom-id-42a8f3c3a7caf68cbbd7604909537de88358ac60e75b84dd6234cf3cf2c4b4aa"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1347731" hreflang="en">A concerted neuron-astrocyte program declines in ageing and schizophrenia.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1332836" hreflang="en">Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1339771" hreflang="en">Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1340926" hreflang="en">Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1341481" hreflang="en">Spatial atlas of the mouse central nervous system at molecular resolution.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1343616" hreflang="en">The molecular cytoarchitecture of the adult mouse brain.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1343761" hreflang="en">Shifting the trajectory of therapeutic development for neurological and psychiatric disorders.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1331646" hreflang="en">Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer&#039;s disease.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1168921" hreflang="en">Pyramidal neuron subtype diversity governs microglia states in the neocortex.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1132461" hreflang="en">Improving polygenic prediction in ancestrally diverse populations.</a></span></div></div> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockrelated-items-list"> <div class="related-items-list-wrapper"> <h3>Related</h3> <div><div class="view--blazy view view-related-items view-id-related_items view-display-id-list js-view-dom-id-12e816ec9f68ea9d32fddeec72db33bc817524c09218cb01b3429eebb2383191"> <div class="view-content"> <div class="slick blazy slick--view slick--view--related-items slick--view--related-items--list slick--view--related-items-block-list slick--skin--default slick--optionset--slider-with-tabs-module" data-blazy=""><div id="slick-108248bb8ce" 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layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/largest-ever-genetic-study-epilepsy-finds-possible-therapeutic-targets">News 10.03.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/largest-ever-genetic-study-epilepsy-finds-possible-therapeutic-targets" hreflang="en">Largest-ever genetic study of epilepsy finds possible therapeutic targets</a></span> </div> <div class="block-teaser-link block block-layout-builder block-extra-field-blocknodelong-storyextra-field-readmore"> <div class="field field--name-extra-field-readmore field--type-extra-field field--label-hidden field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/largest-ever-genetic-study-epilepsy-finds-possible-therapeutic-targets" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--1"> <article about="/news/machine-learning-approach-helps-researchers-design-better-gene-delivery-vehicles-gene-therapy" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/machine-learning-approach-helps-researchers-design-better-gene-delivery-vehicles-gene-therapy"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=7Bu3W0j2 1x" media="all and (min-width: 1921px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=7Bu3W0j2 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=7Bu3W0j2 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=kqvVz7HR 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=Dqd3LyEP 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=tI3_UhoU 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" width="500" height="400" src="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/News_ML-proteins_hi-res-ext_0824.png?itok=tI3_UhoU" alt="Graphic showing an AAV in front of circuits." title="Graphic showing an AAV in front of circuits." typeof="foaf:Image" /> 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field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/machine-learning-approach-helps-researchers-design-better-gene-delivery-vehicles-gene-therapy" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--2"> <article about="/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <a href="https://www.broadinstitute.org/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders"><picture> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DSC_1860-horizontal-2.jpg?itok=6H9byPjM 1x" media="all and (min-width: 1921px)" type="image/jpeg" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DSC_1860-horizontal-2.jpg?itok=6H9byPjM 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/jpeg" width="768" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_desktop/public/longstory/DSC_1860-horizontal-2.jpg?itok=6H9byPjM 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/jpeg" width="768" height="400"/> <source 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layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders">News 07.25.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders" hreflang="en">Q&amp;A: How a stem cell bank is helping scientists understand psychiatric disorders</a></span> </div> <div class="block-teaser-link block block-layout-builder block-extra-field-blocknodelong-storyextra-field-readmore"> <div class="field field--name-extra-field-readmore field--type-extra-field field--label-hidden field__items"> <div class="field__item"><a href="https://www.broadinstitute.org/news/qa-how-stem-cell-bank-helping-scientists-understand-psychiatric-disorders" hreflang="en">Read more</a></div> </div> </div> </div> </div> </div> </article> </div> <div class="slick__slide slide slide--3"> <article about="/news/brain-chimeroids-offer-window-relationships-between-genetics-and-exposures" class="node node--type-long-story node--promoted node--view-mode-teaser-related-items"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="block-teaser-image block block-layout-builder block-field-blocknodelong-storyfield-preview-image"> <div class="field field--name-field-preview-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-multiple-ct-teaser-related-items"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> 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srcset="/files/styles/multiple_ct_teaser_related_items_laptop/public/longstory/Arlotta%20lab_chimeroid_Figure1_120mm_V4_CMYK-02.png?itok=pVDRtQ_K 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="610" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_tablet/public/longstory/Arlotta%20lab_chimeroid_Figure1_120mm_V4_CMYK-02.png?itok=_Y699kzn 1x" media="all and (min-width: 540px) and (max-width: 799px)" type="image/png" width="735" height="400"/> <source srcset="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/Arlotta%20lab_chimeroid_Figure1_120mm_V4_CMYK-02.png?itok=WDDZ3HA7 1x" media="all and (max-width: 539px)" type="image/png" width="500" height="400"/> <img loading="eager" width="500" height="400" src="/files/styles/multiple_ct_teaser_related_items_phone/public/longstory/Arlotta%20lab_chimeroid_Figure1_120mm_V4_CMYK-02.png?itok=WDDZ3HA7" alt="Color microscope image of a brain chimeroid, with red and green colors highlighting different types of cells and different structures." title="Color microscope image of a brain chimeroid, with red and green colors highlighting different types of cells and different structures." typeof="foaf:Image" /> </picture></a> </div> </article> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="block-teaser-date block block-layout-builder block-extra-field-blocknodelong-storyextra-field-news-tag-date"> <a href="/news/brain-chimeroids-offer-window-relationships-between-genetics-and-exposures">News 07.08.2024</a> </div> <div class="block-teaser-title block block-layout-builder block-field-blocknodelong-storytitle"> <span class="field field--name-title field--type-string field--label-hidden"><a href="/news/brain-chimeroids-offer-window-relationships-between-genetics-and-exposures" hreflang="en">Brain chimeroids offer window into relationships between genetics and exposures</a></span> </div> <div class="block-teaser-link 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