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genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.</span></a></li><li id="header-menu-menu-link-content160561bf-c8e9-4bf6-aca8-4d2848930259" class="sf-depth-2 sf-no-children"><a href="/gerstner-center-cancer-diagnostics" class="sf-depth-2" title="The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.">Gerstner Center for Cancer Diagnostics <span class="sf-description">The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.</span></a></li><li id="header-menu-menu-link-contenta1450e5b-1fbb-4d9e-85f7-e0df335ada8c" class="sf-depth-2 sf-no-children"><a href="/klarman-cell-observatory" class="sf-depth-2" title="The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.">Klarman Cell Observatory <span class="sf-description">The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.</span></a></li><li id="header-menu-menu-link-contentf919ca42-db45-41ce-8888-efe027a9fb36" class="sf-depth-2 sf-no-children"><a href="/merkin-institute-transformative-technologies-healthcare" class="sf-depth-2" title="The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.">Merkin Institute for Transformative Technologies in Healthcare <span class="sf-description">The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.</span></a></li><li id="header-menu-menu-link-contentb12c2ad1-a84c-455a-821e-59bfd482c758" class="sf-depth-2 sf-no-children"><a href="/nnfc" class="sf-depth-2" title="This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.">Novo Nordisk Foundation Center for Genomic Mechanisms of Disease <span class="sf-description">This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community.</span></a></li><li id="header-menu-menu-link-content317da4e7-16de-4bbc-95da-f3ea10e0c178" class="sf-depth-2 sf-no-children"><a href="/ewsc" class="sf-depth-2" title="The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.">Eric and Wendy Schmidt Center <span class="sf-description">The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.</span></a></li><li id="header-menu-menu-link-content13d4c1b3-4076-45da-bf73-8a5d2c08222e" class="sf-depth-2 sf-no-children"><a href="/stanley-center-for-psychiatric-research" class="sf-depth-2" title="The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.">Stanley Center for Psychiatric Research <span class="sf-description">The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.</span></a></li></ol></li></ul></li><li id="header-menu-menu-link-content77da995c-f5d1-4f7a-bcf0-9955394a546b" class="sf-depth-1 menuparent"><a href="/education-and-outreach" class="sf-depth-1 menuparent">Education and outreach</a><ul 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class="node__content"> <div class="hero-section hero-section_image-bottom container"> <div class="hero-section__row row"> <div class="hero-section__content col-8 offset-2"> <div class="hero-section__breadcrumbs"> <div class="block block-system block-system-breadcrumb-block"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/technology-areas">Technology Areas</a> </li> </ol> </nav> </div> </div> <div class="hero-section__title"> <div class="block block-layout-builder block-field-blocknodelanding-pagetitle"> <span class="field field--name-title field--type-string field--label-hidden"><h1>Spatial Technology Platform</h1> </span> </div> </div> <div class="hero-section__description"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-featured-description"> <div class="clearfix text-formatted field field--name-field-featured-description field--type-text-long field--label-hidden field__item"><p>To advance cutting edge spatial and imaging technologies </p> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="block block-layout-builder block-field-blocknodelanding-pagefield-content-paragraphs"> <div class="field field--name-field-content-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--home-banner home-banner"> <div class="home-banner-container"> <div class="field field--name-field-image field--type-entity-reference field--label-hidden field__item"><article class="media media--type-image media--view-mode-pt-home-banner"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/files/styles/pt_home_banner_desktop/public/2024-03/SARDANA_CRC_resized_small.png?h=12a0cd32&itok=Z-Ifpmdy 1x" media="all and (min-width: 1921px)" type="image/png" width="1800" height="659"/> <source srcset="/files/styles/pt_home_banner_desktop/public/2024-03/SARDANA_CRC_resized_small.png?h=12a0cd32&itok=Z-Ifpmdy 1x" media="all and (min-width: 1601px) and (max-width: 1920px)" type="image/png" width="1800" height="659"/> <source srcset="/files/styles/pt_home_banner_tablet/public/2024-03/SARDANA_CRC_resized_small.png?h=12a0cd32&itok=b5vM3Rmg 1x" media="all and (min-width: 1340px) and (max-width: 1600px)" type="image/png" width="1025" height="440"/> <source srcset="/files/styles/pt_home_banner_tablet/public/2024-03/SARDANA_CRC_resized_small.png?h=12a0cd32&itok=b5vM3Rmg 1x" media="all and (min-width: 800px) and (max-width: 1339px)" type="image/png" width="1025" height="440"/> <source 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field--name-field-link field--type-link field--label-hidden field__item"><a href="/spatial-technology-platform/platform-capabilities">/spatial-technology-platform/platform-capabilities</a></div> </div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--text-with-sidebar text-with-sidebar"> <div class="field field--name-field-sidebar field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--menu-reference paragraph--view-mode--default"> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="open block block-broad-menu-reference block-broad-menu-blockadmin"> <h2>Spatial Technology Platform</h2> <ul class="menu"> <li class="menu-item"> <a href="/spatial-technology-platform" data-drupal-link-system-path="node/5556461" class="is-active" aria-current="page">About</a> </li> <li class="menu-item menu-item--expanded"> <div class="dropdown-reference"> <a href="/spatial-technology-platform/platform-capabilities" data-drupal-link-system-path="node/5556671">Platform capabilities</a> <div class="dropdown-reference-btn"></div> </div> <ul class="menu"> <li class="menu-item"> <a href="/spatial-technology-platform/platform-capabilities" data-drupal-link-system-path="node/5556671">Technologies</a> </li> <li class="menu-item"> <a href="/broad-technology-labs/faq" data-drupal-link-system-path="node/5556666">FAQ</a> </li> </ul> </li> <li class="menu-item"> <a href="/technology-areas-spatial-technology-platform/spatial-technology-platform-team" data-drupal-link-system-path="node/5556681">Team</a> </li> <li class="menu-item"> <a href="/spatial-technology-platform/social" data-drupal-link-system-path="node/5556856">Social</a> </li> <li class="menu-item menu-item--expanded"> <div class="dropdown-reference"> <a href="/spatial-technology-platform/research" data-drupal-link-system-path="node/5556646">Research</a> <div class="dropdown-reference-btn"></div> </div> <ul class="menu"> <li class="menu-item"> <a href="/spatial-technology-platform/research#farhi" data-drupal-link-system-path="node/5556646">Farhi group</a> </li> <li class="menu-item"> <a href="/spatial-technology-platform/research#lipinski" data-drupal-link-system-path="node/5556646">Lipinski group</a> </li> <li class="menu-item"> <a href="/spatial-technology-platform/research#fernandez" data-drupal-link-system-path="node/5556646">Fernandez group</a> </li> <li class="menu-item"> <a href="/spatial-technology-platform/research#barner" data-drupal-link-system-path="node/5556646">Erion-Barner group</a> </li> </ul> </li> <li class="menu-item"> <a href="/spatial-technology-platform/partner-us" data-drupal-link-system-path="node/5556656">Collaborate with us</a> </li> <li class="menu-item"> <a href="/technology-areas/spatial-technology-platform/join-team" data-drupal-link-system-path="node/5556661">Join us</a> </li> </ul> </div> </div> </div> </div> </div> </div> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Spatial transcriptomics, multiplexed immunofluorescence, and other imaging-based spatial technologies have enabled biologists to study single-cell gene and protein expression with spatial context to answer critical biological questions in a variety of animal models, tissue types, and clinical samples. </p> <p>The Spatial Technology Platform (STP) further expands the impact of spatial -omics through comprehensive support–from study design to data acquisition and processing–for a broad range of users.  We also maintain an active research arm that develops and advances cutting edge spatial, imaging, and computational technologies.</p> <p> </p> <h2>Collaborate with STP</h2> <p>We provide full stack support of spatial studies, beginning with advice on study design; progressing through sample handling and data acquisition; and finally to providing tools for low level data processing. We consult on data interpretation and provide resources for self guided data analysis, serve as collaborators on large scale biological projects, and collaborate to develop new tools when existing methods cannot answer a stated question. We have experience with multiple small scale (<10) and large scale (>100) projects. Our organization is structured so that anyone, regardless of affiliation or not-for-profit status can take advantage of our capabilities. Finally, as a “Specialized Service Facility” (SSF) our prices are designed to be more competitive than doing experiments yourself, while still taking advantage of our expertise. </p> <p> </p> <h2>Research at STP</h2> <p>The STP has an active research wing driven by the leadership team that conducts independent research in the following areas:</p> <ul> <li>Algorithms for preprocessing spatial omics and benchmarking</li> <li>In situ Perturb-Seq</li> <li>Cell painting in tissue</li> <li>Light sheet spatial omics </li> <li>Utilizing spatial tools in new contexts</li> <li>Novel computational and visualization techniques</li> <li>And more…</li> </ul> </div> </div> </div> </div> </div> </div> </div> <div class="content-section container"> <div class="content-section__main"> <div class="views-element-container block block-views block-views-blockrelated-publications-list-more-link"> <div class="publications-list-wrapper"> <div class="publications-list-wrapper__title"> <h2>Recent publications</h2> <div class="more-link"> <a href="/publications-list/2991">Other Spatial Technology Platform publications</a> </div> </div> <div><div class="view view-related-publications view-id-related_publications view-display-id-list_more_link js-view-dom-id-e809a185c57a4de05eee5866766f33ea0b8150a2294b65da167ad9702f9f1d4d"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1347941" hreflang="en">Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1331656" hreflang="en">Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1339136" hreflang="en">Optimization-based decoding of Imaging Spatial Transcriptomics data.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1340131" hreflang="en">Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1344711" hreflang="en">Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1344946" hreflang="en">Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1168921" hreflang="en">Pyramidal neuron subtype diversity governs microglia states in the neocortex.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1153581" hreflang="en">Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1145901" hreflang="en">The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.</a></span></div></div> <div class="views-row"><div class="views-field views-field-title"><span class="field-content"><a href="/publications/broad1347946" hreflang="en">MITI minimum 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