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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-EH6QSG2FJ8"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-EH6QSG2FJ8", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Note: the Hay Lab has moved to the University of Calgary. While Dr. Hay remains an Associate Scientist with TFL, BC Cancer Research Centre, his laboratory is now physically located at UCalgary. All inquiries regarding supervision should be directed there.My research focuses on preclinical development, bench-to-bedside translation, and clinical evaluation of novel cellular immunotherapeutic approaches, with an expertise in chimeric antigen receptor (CAR-)T cell therapy." /> <link rel="canonical" href="https://www.bccrc.ca/dept/tfl/labs/hay-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/tfl/sites/terryfoxlab.ca/files/BCClogo_Research_TerryFoxLaboratory_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/tfl/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Hay Lab | Terry Fox Laboratory</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/tfl/sites/terryfoxlab.ca/files/css/css_Bxn9zpdS07My99x7G76QyiQFY-SQtLPW6RDCCblqJIQ.css?delta=0&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/tfl/sites/terryfoxlab.ca/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> </head> <body class="colour--navy not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/tfl/">Terry Fox Laboratory</a> </li> <li> Hay Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Hay Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/tfl/dept/tfl/people/kevin-hay" class="button"><span>Kevin Hay, MD, MSc, FRCPC</span> </a> <div class="field field--field_admin_contact"> <div class="above field--label">Admin Contact</div> <div> <div class="field field--item field--field_admin_contact"><article class="node node--profile assistant"> <div class="field--name"> <span>Jordan Cran, MSc, PMP</span> </div> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Projects Manager</div> </div> <div class="field field--field_phone_number"><a href="tel:604-675-8126">604-675-8126</a></div> </article> </div> </div> </div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>Note: <strong>the Hay Lab has moved to the </strong><a href="https://profiles.ucalgary.ca/kevin-hay"><strong>University of Calgary</strong></a>. While Dr. Hay remains an Associate Scientist with TFL, BC Cancer Research Centre, his laboratory is now physically located at UCalgary. All inquiries regarding supervision should be directed there.</p><hr><p>My research focuses on preclinical development, bench-to-bedside translation, and clinical evaluation of novel cellular immunotherapeutic approaches, with an expertise in chimeric antigen receptor (CAR-)T cell therapy.</p><p>A CAR is comprised of an extracellular antigen recognition domain linked to intracellular T cell signaling domains, which after introduction into the T cell enables T cell activation upon encounter with the target antigen. Clinical trials of CAR-T cells targeting CD19 have demonstrated impressive results in the treatment of patients with relapsed/refractory B-cell malignancies such acute lymphoblastic leukemia (ALL), non-Hodgkin鈥檚 lymphoma, and chronic lymphocytic leukemia (CLL), with response rate >80% for some cancers, highlighting the promise and feasibility of this cellular therapeutic approach.</p><p>My laboratory aims to: (a) develop CAR-T cells targeting other malignancies, such as myeloma, and (b) modify CAR-T cells so as to improve efficacy and decrease toxicity. We are exploring multi-antigen targeting approaches, modifications to the CAR construct, and different approaches to T cell manufacturing.</p><p>My clinical research with the Leukemia/BMT Program of BC focuses on the development of a CAR-T program in BC and involvement in clinical trials of CAR-T cell therapy.</p><p><iframe src="https://www.youtube.com/embed/U90fR82hsCs?rel=0" allow=";" allowfullscreen frameborder="0"></iframe></p><p>Check out the above video. Dr. Hay provides a research and clinical trial update from the Leukemia & Lymphoma Society of Canada's Leukemia Conference held November 9, 2019 at VanDusen Botanical Gardens Visitor Centre in Vancouver. In this video: Megan Norrish, BC Community Engagement Manager for the LLSC; Dr. Florian Kuchenbauer, clinical scientist, associate professor at UBC; Dr. Kevin Hay, hematologist, assistant professor at UBC.</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/tfl/people/kevin-hay" ><figure> <img loading="lazy" src="/dept/tfl/dept/tfl/sites/terryfoxlab.ca/files/styles/profile/public/2019-10/TFL_KevinHay.jpeg?itok=RlaeU_FN" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/tfl/people/kevin-hay" rel="bookmark">Kevin Hay, MD, MSc, FRCPC</a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Associate Scientist</div> </div> <div class="field field--field_labs"> <div class="field field--item field--field_labs"><a href="/dept/tfl/labs/hay-lab" hreflang="en">Hay Lab</a></div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/tfl/contact/117" class="more">Send message</a> <a href="/dept/tfl/people/kevin-hay" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/sites/terryfoxlab.ca/files/styles/profile/public/2023-02/JCRAN_2022_01.jpg?itok=tPzpf4Lv" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Jordan Cran, MSc, PMP </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Projects Manager</div> </div> <div class="field field--field_labs"> <div class="field field--item field--field_labs"><a href="/dept/tfl/labs/hoodless-lab" hreflang="en">Hoodless Lab</a></div> <div class="field field--item field--field_labs"><a href="/dept/tfl/labs/brinkman-lab" hreflang="en">Brinkman Lab</a></div> <div class="field field--item field--field_labs"><a href="/dept/tfl/labs/hay-lab" hreflang="en">Hay Lab</a></div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8126">604-675-8126</a></div> <a href= "https://www.bccrc.ca/dept/tfl/contact/23" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title">Students/Trainees</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/dept/tfl/sites/terryfoxlab.ca/files/styles/profile/public/2020-01/TFL_LorenzoLindo.jpeg?itok=Fy8_V9do" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Lorenzo Lindo </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate student</div> </div> <div class="field field--field_labs"> <div class="field field--item field--field_labs"><a href="/dept/tfl/labs/hay-lab" hreflang="en">Hay Lab</a></div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7769">604-675-8000 ext. 7769</a></div> <a href= "https://www.bccrc.ca/dept/tfl/contact/375" class="more">Send message</a> </div> </section> </article> </div></section> <section id="publications" class="layout layout__expanding layout__publications"><h2 class="section__title">Selected Publications</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/38819367" target="_blank" rel="bookmark">Outcomes with allogeneic stem cell transplant using cryopreserved versus fresh hematopoietic progenitor cell products.</a> </h2> <div class="field field--field_journal">Cytotherapy, 2024</div> <div class="field field--field_authors">Wan, Bo Angela, Lindo, Lorenzo, Mourad, Yasser Abou, Chung, Shanee, Forrest, Donna, Kuchenbauer, Florian, Nantel, Stephen, Narayanan, Sujaatha, Nevill, Tomas, Power, Maryse, Rodrigo, Judith, Sanford, David, Song, Kevin, Stubbins, Ryan J, Sutherland, Heather, Toze, Cynthia L, White, Jennifer, Roy, Claudie, Hay, Kevin A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/38819367" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/38596311" target="_blank" rel="bookmark">Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22.</a> </h2> <div class="field field--field_journal">Molecular therapy. Oncology, 2024</div> <div class="field field--field_authors">McComb, Scott, Arbabi-Ghahroudi, Mehdi, Hay, Kevin A, Keller, Brian A, Faulkes, Sharlene, Rutherford, Michael, Nguyen, Tina, Shepherd, Alex, Wu, Cunle, Marcil, Anne, Aubry, Annie, Hussack, Greg, Pinto, Devanand M, Ryan, Shannon, Raphael, Shalini, van Faassen, Henk, Zafer, Ahmed, Zhu, Qin, Maclean, Susanne, Chattopadhyay, Anindita, Gurnani, Komal, Gilbert, R茅nald, Gadoury, Christine, Iqbal, Umar, Fatehi, Dorothy, Jezierski, Anna, Huang, Jez, Pon, Robert A, Sigrist, Mhairi, Holt, Robert A, Nelson, Brad H, Atkins, Harold, Kekre, Natasha, Yung, Eric, Webb, John, Nielsen, Julie S, Weeratna, Risini D</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/38596311" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37999143" target="_blank" rel="bookmark">Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-Based Cohort Study.</a> </h2> <div class="field field--field_journal">Current oncology (Toronto, Ont.), 2023</div> <div class="field field--field_authors">Seftel, Matthew D, Pasic, Ivan, Parmar, Gaganvir, Bucher, Oliver, Allan, David S, Bhella, Sita, Hay, Kevin Anthony, Ikuomola, Oluwaseun, Musto, Grace, Prica, Anca, Richardson, Erin, Truong, Tony H, Paulson, Kristjan</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37999143" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37180149" target="_blank" rel="bookmark">A systematic review and meta-analysis of CD22 CAR T-cells alone or in combination with CD19 CAR T-cells.</a> </h2> <div class="field field--field_journal">Frontiers in immunology, 2023</div> <div class="field field--field_authors">Fergusson, Nathan J, Adeel, Komal, Kekre, Natasha, Atkins, Harold, Hay, Kevin A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37180149" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36653879" target="_blank" rel="bookmark">Identifying effect modifiers of CAR-T cell therapeutic efficacy: a systematic review and individual patient data meta-analysis protocol.</a> </h2> <div class="field field--field_journal">Systematic reviews, 2023</div> <div class="field field--field_authors">Lalu, Manoj M, Kekre, Natasha, Montroy, Joshua, Ghiasi, Maryam, Hay, Kevin, McComb, Scott, Weeratna, Risini, Atkins, Harold, Hutton, Brian, Yahya, Ayel, Masurekar, Ashish, Sobh, Mohamad, Fergusson, Dean A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36653879" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/36601119" target="_blank" rel="bookmark">CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies.</a> </h2> <div class="field field--field_journal">Frontiers in immunology, 2022</div> <div class="field field--field_authors">Kekre, Natasha, Hay, Kevin A, Webb, John R, Mallick, Ranjeeta, Balasundaram, Miruna, Sigrist, Mhairi K, Clement, Anne-Marie, Nielsen, Julie S, Quizi, Jennifer, Yung, Eric, Brown, Scott D, Dreolini, Lisa, Waller, Daniel D, Smazynski, Julian, Gierc, Nicole S, Loveless, Bianca C, Clark, Kayla, Dyer, Tyler, Hogg, Richard, McCormick, Leah, Gignac, Michael, Bell, Shanti, Chapman, D Maria, Bond, David, Yong, Siao, Fung, Rachel, Lockyer, Heather M, Hodgson, Victoria, Murphy, Catherine, Subramanian, Ana, Wiebe, Evelyn, Yoganathan, Piriya, Medynski, Liana, Vaillan, Dominique C, Black, Alice, McDiarmid, Sheryl, Kennah, Michael, Hamelin, Linda, Song, Kevin, Narayanan, Sujaatha, Rodrigo, Judith A, Dupont, Stefany, Hawrysh, Terry, Presseau, Justin, Thavorn, Kednapa, Lalu, Manoj M, Fergusson, Dean A, Bell, John C, Atkins, Harold, Nelson, Brad H, Holt, Robert A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/36601119" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/34426446" target="_blank" rel="bookmark">Innovations in cancer immunotherapy: chimeric antigen receptor T-cell therapy (CAR-T).</a> </h2> <div class="field field--field_journal">CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2021</div> <div class="field field--field_authors">Brown, Kevin, Seftel, Matthew D, Hay, Kevin A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/34426446" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/33478595" target="_blank" rel="bookmark">Efficacy and safety of CD22 chimeric antigen receptor (CAR) T cell therapy in patients with B cell malignancies: a protocol for a systematic review and meta-analysis.</a> </h2> <div class="field field--field_journal">Systematic reviews, 2021</div> <div class="field field--field_authors">Adeel, Komal, Fergusson, Nathan J, Shorr, Risa, Atkins, Harold, Hay, Kevin A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/33478595" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/32425294" target="_blank" rel="bookmark">Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes.</a> </h2> <div class="field field--field_journal">Blood reviews, 2021</div> <div class="field field--field_authors">England, James T, Abdulla, Alym, Biggs, Catherine M, Lee, Agnes Y Y, Hay, Kevin A, Hoiland, Ryan L, Wellington, Cheryl L, Sekhon, Mypinder, Jamal, Shahin, Shojania, Kamran, Chen, Luke Y C</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32425294" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/32688454" target="_blank" rel="bookmark">Building Canadian capacity for CAR-T cells in relapsed/refractory acute lymphoblastic leukaemia: a retrospective cohort study.</a> </h2> <div class="field field--field_journal">British journal of haematology, 2020</div> <div class="field field--field_authors">Khalife, Roy, Montroy, Joshua, Grigor, Emma J M, Fergusson, Dean A, Atkins, Harold, Seftel, Matthew, Presseau, Justin, Thavorn, Kednapa, Holt, Robert A, Hay, Kevin, Lalu, Manoj M, Kekre, Natasha</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32688454" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/32584416" target="_blank" rel="bookmark">Amelioration of COVID-19-related cytokine storm syndrome: parallels to chimeric antigen receptor-T cell cytokine release syndrome.</a> </h2> <div class="field field--field_journal">British journal of haematology, 2020</div> <div class="field field--field_authors">Hoiland, Ryan L, Stukas, Sophie, Cooper, Jennifer, Thiara, Sonny, Chen, Luke Y C, Biggs, Catherine M, Hay, Kevin, Lee, Agnes Y Y, Shojania, Kamran, Abdulla, Alym, Wellington, Cheryl L, Sekhon, Mypinder S</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32584416" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/32189546" target="_blank" rel="bookmark">Potentials, challenges and future of chimeric antigen receptor T-cell therapy in non-Hodgkin lymphomas.</a> </h2> <div class="field field--field_journal">Acta oncologica (Stockholm, Sweden), 2020</div> <div class="field field--field_authors">El-Galaly, Tarec Christoffer, Cheah, Chan Yoon, Kristensen, Daniel, Hutchison, Andrew, Hay, Kevin, Callr茅us, Torbj枚rn, Villa, Diego</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/32189546" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/33643299" target="_blank" rel="bookmark">Befriending the Hostile Tumor Microenvironment in CAR T-Cell Therapy.</a> </h2> <div class="field field--field_journal">Frontiers in immunology, 2020</div> <div class="field field--field_authors">Lindo, Lorenzo, Wilkinson, Lauren Hanna, Hay, Kevin Anthony</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/33643299" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31743392" target="_blank" rel="bookmark">Durable preservation of antiviral antibodies after CD19-directed chimeric antigen receptor T-cell immunotherapy.</a> </h2> <div class="field field--field_journal">Blood advances, 2019</div> <div class="field field--field_authors">Hill, Joshua A, Krantz, Elizabeth M, Hay, Kevin A, Dasgupta, Sayan, Stevens-Ayers, Terry, Bender Ignacio, Rachel A, Bar, Merav, Maalouf, Joyce, Cherian, Sindhu, Chen, Xueyan, Pepper, Greg, Riddell, Stanley R, Maloney, David G, Boeckh, Michael J, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31743392" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31648329" target="_blank" rel="bookmark">Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy.</a> </h2> <div class="field field--field_journal">Blood advances, 2019</div> <div class="field field--field_authors">Shadman, Mazyar, Gauthier, Jordan, Hay, Kevin A, Voutsinas, Jenna M, Milano, Filippo, Li, Ang, Hirayama, Alexandre V, Sorror, Mohamed L, Cherian, Sindhu, Chen, Xueyan, Cassaday, Ryan D, Till, Brian G, Gopal, Ajay K, Sandmaier, Brenda M, Maloney, David G, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31648329" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30782611" target="_blank" rel="bookmark">The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.</a> </h2> <div class="field field--field_journal">Blood, 2019</div> <div class="field field--field_authors">Hirayama, Alexandre V, Gauthier, Jordan, Hay, Kevin A, Voutsinas, Jenna M, Wu, Qian, Gooley, Ted, Li, Daniel, Cherian, Sindhu, Chen, Xueyan, Pender, Barbara S, Hawkins, Reed M, Vakil, Aesha, Steinmetz, Rachel N, Acharya, Utkarsh H, Cassaday, Ryan D, Chapuis, Aude G, Dhawale, Tejaswini M, Hendrie, Paul C, Kiem, Hans-Peter, Lynch, Ryan C, Ramos, Jorge, Shadman, Mazyar, Till, Brian G, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30782611" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30728140" target="_blank" rel="bookmark">Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.</a> </h2> <div class="field field--field_journal">Blood, 2019</div> <div class="field field--field_authors">Hay, Kevin A, Gauthier, Jordan, Hirayama, Alexandre V, Voutsinas, Jenna M, Wu, Qian, Li, Daniel, Gooley, Ted A, Cherian, Sindhu, Chen, Xueyan, Pender, Barbara S, Hawkins, Reed M, Vakil, Aesha, Steinmetz, Rachel N, Schoch, Gary, Chapuis, Aude G, Till, Brian G, Kiem, Hans-Peter, Ramos, Jorge D, Shadman, Mazyar, Cassaday, Ryan D, Acharya, Utkarsh H, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30728140" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30407609" target="_blank" rel="bookmark">Cytokine release syndrome and neurotoxicity after CD19 chimeric antigen receptor-modified (CAR-) T cell therapy.</a> </h2> <div class="field field--field_journal">British journal of haematology, 2018</div> <div class="field field--field_authors">Hay, Kevin A</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30407609" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29038338" target="_blank" rel="bookmark">Infectious complications of CD19-targeted chimeric antigen receptor-modified T-cell immunotherapy.</a> </h2> <div class="field field--field_journal">Blood, 2018</div> <div class="field field--field_authors">Hill, Joshua A, Li, Daniel, Hay, Kevin A, Green, Margaret L, Cherian, Sindhu, Chen, Xueyan, Riddell, Stanley R, Maloney, David G, Boeckh, Michael, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29038338" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/29025771" target="_blank" rel="bookmark">Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.</a> </h2> <div class="field field--field_journal">Cancer discovery, 2017</div> <div class="field field--field_authors">Gust, Juliane, Hay, Kevin A, Hanafi, La茂la-A茂cha, Li, Daniel, Myerson, David, Gonzalez-Cuyar, Luis F, Yeung, Cecilia, Liles, W Conrad, Wurfel, Mark, Lopez, Jose A, Chen, Junmei, Chung, Dominic, Harju-Baker, Susanna, 脰zpolat, Tahsin, Fink, Kathleen R, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/29025771" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28924019" target="_blank" rel="bookmark">Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor-modified T-cell therapy.</a> </h2> <div class="field field--field_journal">Blood, 2017</div> <div class="field field--field_authors">Hay, Kevin A, Hanafi, La茂la-A茂cha, Li, Daniel, Gust, Juliane, Liles, W Conrad, Wurfel, Mark M, L贸pez, Jos茅 A, Chen, Junmei, Chung, Dominic, Harju-Baker, Susanna, Cherian, Sindhu, Chen, Xueyan, Riddell, Stanley R, Maloney, David G, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28924019" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28715249" target="_blank" rel="bookmark">Durable Molecular Remissions in Chronic Lymphocytic Leukemia Treated With CD19-Specific Chimeric Antigen Receptor-Modified T Cells After Failure of Ibrutinib.</a> </h2> <div class="field field--field_journal">Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017</div> <div class="field field--field_authors">Turtle, Cameron J, Hay, Kevin A, Hanafi, La茂la-A茂cha, Li, Daniel, Cherian, Sindhu, Chen, Xueyan, Wood, Brent, Lozanski, Arletta, Byrd, John C, Heimfeld, Shelly, Riddell, Stanley R, Maloney, David G</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28715249" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28110394" target="_blank" rel="bookmark">Chimeric Antigen Receptor (CAR) T Cells: Lessons Learned from Targeting of CD19 in B-Cell Malignancies.</a> </h2> <div class="field field--field_journal">Drugs, 2017</div> <div class="field field--field_authors">Hay, Kevin A, Turtle, Cameron J</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28110394" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26010123" target="_blank" rel="bookmark">Impact of time from diagnosis to initiation of curative chemotherapy on survival of patients with diffuse large B-cell lymphoma.</a> </h2> <div class="field field--field_journal">Leukemia & lymphoma, 2016</div> <div class="field field--field_authors">Hay, Kevin, Lee, Benny, Goktepe, Ozge, Connors, Joseph M, Sehn, Laurie H, Savage, Kerry J, Klasa, Richard, Shenkier, Tamara, Gerrie, Alina, Villa, Diego</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26010123" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/24569946" target="_blank" rel="bookmark">Effect of place of residence and treatment on survival outcomes in patients with diffuse large B-cell lymphoma in British Columbia.</a> </h2> <div class="field field--field_journal">The oncologist, 2014</div> <div class="field field--field_authors">Lee, Benny, Goktepe, Ozge, Hay, Kevin, Connors, Joseph M, Sehn, Laurie H, Savage, Kerry J, Shenkier, Tamara, Klasa, Richard, Gerrie, Alina, Villa, Diego</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/24569946" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/20168090" target="_blank" rel="bookmark">Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology.</a> </h2> <div class="field field--field_journal">mAbs</div> <div class="field field--field_authors">Berry, Jody D, Hay, Kevin, Rini, James M, Yu, Meng, Wang, Linfa, Plummer, Francis A, Corbett, Cindi R, Andonov, Anton</div> <div class="field field--field_pubmed_id"><a 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id="Molecular-Oncology"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/mo">Molecular Oncology</a></h2></li><li><a href="https://www.bccrc.ca/dept/mo/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/mo/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/mo/programs" target="_blank">Programs</a></li><li><a href="https://www.bccrc.ca/dept/mo/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/mo/resources" target="_blank">Resources</a></li><li><a href="https://www.bccrc.ca/dept/mo/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/mo/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/mo/careers" target="_blank">Careers</a></li></ul></li><li class="depth--1 external microsite"><a href="https://www.bccrc.ca/dept/io" class="depth--1 external microsite">Integrative Oncology</a><ul class="depth--2 microsite" id="Integrative-Oncology"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/io">Integrative Oncology</a></h2></li><li><a href="https://www.bccrc.ca/dept/io/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/io/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/io/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/io/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/io/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/io/careers" target="_blank">Careers</a></li><li><a href="https://www.bccrc.ca/dept/io/programs" target="_blank">Programs</a></li></ul></li><li class="depth--1 external microsite"><a href="https://www.bccrc.ca/dept/lcr" class="depth--1 external microsite">Lymphoid Cancer Research</a><ul class="depth--2 microsite" id="Lymphoid-Cancer-Research"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/lcr">Lymphoid Cancer Research</a></h2></li><li><a href="https://www.bccrc.ca/dept/lcr/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/lcr/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/lcr/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/lcr/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/lcr/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/lcr/careers" target="_blank">Careers</a></li><li><a href="https://www.bccrc.ca/dept/lcr/programs" target="_blank">Programs</a></li></ul></li><li class="depth--1 external microsite"><a href="https://www.bccrc.ca/dept/et" class="depth--1 external microsite">Experimental Therapeutics</a><ul class="depth--2 microsite" id="Experimental-Therapeutics"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/et">Experimental Therapeutics</a></h2></li><li><a href="https://www.bccrc.ca/dept/et/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/et/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/et/programs" target="_blank">Programs</a></li><li><a href="https://www.bccrc.ca/dept/et/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/et/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/et/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/et/careers" target="_blank">Careers</a></li></ul></li><li class="depth--1 external microsite"><a href="https://www.bccrc.ca/dept/cid" class="depth--1 external microsite">Clinical Research</a><ul class="depth--2 microsite" id="Clinical-Research"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/cid">Clinical Research</a></h2></li><li><a href="https://www.bccrc.ca/dept/cid/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/cid/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/cid/programs" target="_blank">Programs</a></li><li><a href="https://www.bccrc.ca/dept/cid/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/cid/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/cid/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/cid/careers" target="_blank">Careers</a></li></ul></li><li class="depth--1 external microsite"><a href="https://www.bccrc.ca/dept/drc" class="depth--1 external microsite">Deeley Research Centre</a><ul class="depth--2 microsite" id="Deeley-Research-Centre"><li class="title"><button data-toggle-body="network--open" class="departments">Departments</button><h2 class="site__title"><a href="https://www.bccrc.ca/dept/drc">Deeley Research Centre</a></h2></li><li><a href="https://www.bccrc.ca/dept/drc/about-us" target="_blank">About Us</a></li><li><a href="https://www.bccrc.ca/dept/drc/people" target="_blank">People</a></li><li><a href="https://www.bccrc.ca/dept/drc/services" target="_blank">Services</a></li><li><a href="https://www.bccrc.ca/dept/drc/news" target="_blank">News & Events</a></li><li><a href="https://www.bccrc.ca/dept/drc/students-trainees" target="_blank">Students & Trainees</a></li><li><a href="https://www.bccrc.ca/dept/drc/careers" target="_blank">Careers</a></li><li><a href="https://www.bccrc.ca/dept/drc/programs" target="_blank">Programs</a></li></ul></li><li class="external depth--1"><a href="http://www.bccancer.bc.ca" class="external depth--1">BC Cancer</a></li><li class="external depth--1"><a href="https://bccancerfoundation.com/" class="external depth--1">BC Cancer Foundation</a></li></ul> </section> <section id="block-shareblock" class="block block--share-block block-shareblock"> <div class="share"><span class="label">Share</span> <a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.bccrc.ca%2Fdept%2Ftfl%2Flabs%2Fhay-lab" target="_blank"><i class="fa fa-facebook"></i></a> <a href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.bccrc.ca%2Fdept%2Ftfl%2Flabs%2Fhay-lab&text=Hay Lab" target="_blank"><i class="fa fa-twitter"></i></a> <a 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