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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-VNS5L9E4H7"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-VNS5L9E4H7", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Characterising the molecular changes that underpin the progression and pathogenesis of cancer." /> <link rel="shortlink" href="https://www.bccrc.ca/dept/mo/" /> <link rel="canonical" href="https://www.bccrc.ca/dept/mo/" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/mo/sites/molecularoncology/files/BCClogo_Research_MolecularOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <style>.carousel__slide_139 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/header/public/2019-10/MO%20Stock13_0.jpg?itok=5gsKAOHg)} @media (min-width: 600px) { .carousel__slide_139 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/carousel/public/2019-10/MO%20Stock13_0.jpg?itok=AHPCAsat)}}</style> <style>.carousel__slide_38 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/header/public/2019-10/MO%20Stock21%20flipped.jpg?itok=9Ph47DjC)} @media (min-width: 600px) { .carousel__slide_38 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/carousel/public/2019-10/MO%20Stock21%20flipped.jpg?itok=My7GE1Xh)}}</style> <style>.carousel__slide_140 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/header/public/2019-10/MO%20Stock02.jpg?itok=sfcQ9D_-)} @media (min-width: 600px) { .carousel__slide_140 {background-image: url(https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/styles/carousel/public/2019-10/MO%20Stock02.jpg?itok=AClwIFTG)}}</style> <link rel="icon" href="/dept/mo/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Molecular Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_nYWlFnEygeNSjbTAchYRcwUV5SV9RXtwiJlGbdI-_Tc.css?delta=0&language=en&theme=bccrc&include=eJxFyEEKwzAMBdELqfaZvmThuCixkaK2uX0hULoZmMciLlXgM0ON-N5uk2GPOC8bRyeZrrV5LljBEx9acHTH2uLHfyl5rGQbsWmjuOLUvTJC6TX0HfVu2WdL0y-rOzAj" /> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_c_M5VvJkbKVs1ZmYN8FBs07xuEnQ_GtFDXXNhkMTXvg.css?delta=1&language=en&theme=bccrc&include=eJxFyEEKwzAMBdELqfaZvmThuCixkaK2uX0hULoZmMciLlXgM0ON-N5uk2GPOC8bRyeZrrV5LljBEx9acHTH2uLHfyl5rGQbsWmjuOLUvTJC6TX0HfVu2WdL0y-rOzAj" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=3&language=en&theme=bccrc&include=eJxFyEEKwzAMBdELqfaZvmThuCixkaK2uX0hULoZmMciLlXgM0ON-N5uk2GPOC8bRyeZrrV5LljBEx9acHTH2uLHfyl5rGQbsWmjuOLUvTJC6TX0HfVu2WdL0y-rOzAj" /> </head> <body class="colour--emerald has-carousel front page--front"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--front has-carousel page"> <div class="region__header--inner region--inner"> <nav role="navigation" aria-labelledby="block-utility-menu" id="block-utility"> <h2 class="visually-hidden" id="block-utility-menu">Utility</h2> <ul class="menu"> <li class="menu-item"> <a href="https://www.bccrc.ca/dept/cid" target="_blank"><span class="nomobile">For Patients - </span>Find a Clinical Trial</a> </li> </ul> </nav> <section class="views-element-container block block--views-blockcarousel-block-1 block-views-block-carousel-block-1" id="block-views-block-carousel-block-1"> <div><div class="js-view-dom-id-e18462db28368e430c20fd617846a3996dbbd341050a21251ff34295e92ac46a view view--carousel"> <div class="views-row"><div class="views-field views-field-field-carousel"><div class="field-content"><div class="field field--carousel carousel" data-timeout="5000" data-slides=".layout__carousel_slide"> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_140 tinted" id="paragraph--140"> <div class="inner"> <h2 class="section__title">Molecular Oncology</h2> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_38 tinted" id="paragraph--38"> <div class="inner"> <h2 class="section__title">Molecular Oncology </h2> </div> </section> <section class="layout layout__carousel_slide layout__parent__node carousel__slide_139 tinted" id="paragraph--139"> <div class="inner"> <h2 class="section__title">Molecular Oncology</h2> </div> </section> </div> </div></div></div> </div> </div> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--front full"> <div class="field field--body"><h2>Characterising the molecular changes that underpin the progression and pathogenesis of cancer.</h2></div> </article> <section class="layout layout__callout layout__parent__node paragraph paragraph--type--callout paragraph--view-mode--default" id="our-focus"> <div class="section__title"><h2 class="section__title">Our Focus</h2></div> <div class="inner"> <div class="field field--summary"> <h3>Through the use of cutting edge technologies, Molecular Oncology (MO) aims to identify genes involved in the development of cancer, quickly and accurately.</h3> <p>MO's researchers combine diverse techniques, ranging from genomics, computational biology, tumour imaging, in vitro and in vivo functional models, to study biological and clinical phenotypes. The proteins produced by these genes may serve as targets for novel chemotherapy drugs and other cancer treatments, or imaging scans. MO uses these combined techniques to validate the role of the novel candidate genes in the development of cancer; with an eye towards translating findings into improved treatment options for cancer patients around the world.</p> </div> </div> </section> <section class="layout layout__news layout__parent__node paragraph paragraph--type--news paragraph--view-mode--default" id="paragraph--149"> <h2 class="section__title">News & Events</h2><div class="inner"><div class="featured has-teasers"><article class="node--article teaser"> <a href="/dept/mo/news/recipients-bc-cancer-foundation-2024-rising-stars-award-competition-announced" class="image"><figure class="remote-image"><img src="//www.bccrc.ca/sites/bccrc.ca/files/styles/large/public/2024-12/Rising%20Stars%202024.png?itok=UvRhGz5Z" alt=""></figure></a> <div class="node__inner"> <footer class="node"> <article> </article> <div> <span><time datetime="2024-12-03T09:24:51-08:00" title="Tuesday, December 3, 2024 - 9:24am">Dec 03, 2024</time> </span> </div> </footer> <h2 class="node__title"><a href="/dept/mo/news/recipients-bc-cancer-foundation-2024-rising-stars-award-competition-announced" rel="bookmark"><span>Recipients of BC Cancer Foundation 2024 Rising Stars Award competition announced </span> </a></h2> <div class="field field--body"><p>Congratulations to the recipients of the BC Cancer Foundation (BCCF) 2024 Rising Stars Award competition!</p><p>This year’s awardees are: </p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/news/recipients-bc-cancer-foundation-2024-rising-stars-award-competition-announced" rel="tag" title="Recipients of BC Cancer Foundation 2024 Rising Stars Award competition announced " hreflang="en">More Info<span class="visually-hidden"> about Recipients of BC Cancer Foundation 2024 Rising Stars Award competition announced </span></a></li></ul> </div> </article> </div><div class="teasers"><article class="node--article teaser"> <a href="/dept/mo/news/cancer-mutations-healthy-cells-point-origins-breast-cancer" class="image"><figure class="remote-image"><img src="//www.bccrc.ca/sites/bccrc.ca/files/styles/large/public/2023-12/Sam%20Aparicio.jpg?itok=-OoPBY8q" alt=""></figure></a> <div class="node__inner"> <footer class="node"> <article> </article> <div> <span><time datetime="2024-11-26T09:57:51-08:00" title="Tuesday, November 26, 2024 - 9:57am">Nov 26, 2024</time> </span> </div> </footer> <h2 class="node__title"><a href="/dept/mo/news/cancer-mutations-healthy-cells-point-origins-breast-cancer" rel="bookmark"><span>Cancer-like mutations in healthy cells point to origins of breast cancer</span> </a></h2> <div class="field field--body"><p>Researchers at BC Cancer, the University of British Columbia (UBC), Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer—cancer-like mutations appearing in the cells of healthy women.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/news/cancer-mutations-healthy-cells-point-origins-breast-cancer" rel="tag" title="Cancer-like mutations in healthy cells point to origins of breast cancer" hreflang="en">More Info<span class="visually-hidden"> about Cancer-like mutations in healthy cells point to origins of breast cancer</span></a></li></ul> </div> </article> <article class="node--article teaser"> <a href="/dept/mo/news/dr-poul-sorensen-receives-esteemed-doctors-bc-terry-fox-medal" class="image"><figure class="remote-image"><img src="//www.bccrc.ca/sites/bccrc.ca/files/styles/large/public/2023-11/PoulSorensen.jpg?itok=j-V5KDIb" alt=""></figure></a> <div class="node__inner"> <footer class="node"> <article> </article> <div> <span><time datetime="2024-11-20T09:35:19-08:00" title="Wednesday, November 20, 2024 - 9:35am">Nov 20, 2024</time> </span> </div> </footer> <h2 class="node__title"><a href="/dept/mo/news/dr-poul-sorensen-receives-esteemed-doctors-bc-terry-fox-medal" rel="bookmark"><span>Dr. Poul Sorensen receives esteemed Doctors of BC Terry Fox Medal</span> </a></h2> <div class="field field--body"><p>Dr. Poul Sorensen is the recipient of the 2024 Doctors of BC Terry Fox Medal, a prestigious award recognizing outstanding individuals who have achieved success in clinical practice, research and/or teaching to advance cancer care. A distinguished scientist at the BC Cancer Research Institute (BCCRI) and professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia (UBC), Dr. Sorensen was selected based on his remarkable contributions to the field of pediatric cancer research and in translating scientific discoveries into clinical practice. </p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/news/dr-poul-sorensen-receives-esteemed-doctors-bc-terry-fox-medal" rel="tag" title="Dr. Poul Sorensen receives esteemed Doctors of BC Terry Fox Medal" hreflang="en">More Info<span class="visually-hidden"> about Dr. Poul Sorensen receives esteemed Doctors of BC Terry Fox Medal</span></a></li></ul> </div> </article> <article class="node--article teaser"> <a href="/dept/mo/news/drug-discovery-could-prevent-spread-childhood-bone-cancer" class="image"><figure class="remote-image"><img src="//www.bccrc.ca/sites/bccrc.ca/files/styles/large/public/2024-09/Sorensen%20Lizardo.png?itok=fFmdI3Sw" alt=""></figure></a> <div class="node__inner"> <footer class="node"> <article> </article> <div> <span><time datetime="2024-09-04T12:19:44-07:00" title="Wednesday, September 4, 2024 - 12:19pm">Sep 04, 2024</time> </span> </div> </footer> <h2 class="node__title"><a href="/dept/mo/news/drug-discovery-could-prevent-spread-childhood-bone-cancer" rel="bookmark"><span>Drug discovery could prevent spread of childhood bone cancer</span> </a></h2> <div class="field field--body"><p>Despite decades of advancement in treatment, cancer spreading to multiple parts of the body remains one of the biggest challenges facing patients and their health care teams.</p><p>This is particularly true for osteosarcoma, the most common bone cancer in children and teenagers. While survival rates are approximately 70 per cent for people with localized disease, there is a high risk of metastatic spread to the lungs, after which the odds of survival fall dramatically to 20 per cent or less.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/news/drug-discovery-could-prevent-spread-childhood-bone-cancer" rel="tag" title="Drug discovery could prevent spread of childhood bone cancer" hreflang="en">More Info<span class="visually-hidden"> about Drug discovery could prevent spread of childhood bone cancer</span></a></li></ul> </div> </article> </div></div> </section> </section> <section class="views-element-container block block--views-blocklabs-block-1 block--research-labs block-views-block-labs-block-1" id="block-views-block-labs-block-1"> <h2 class="section__title">Research Labs</h2> <div><div class="js-view-dom-id-2b4bbd29accb972ba585f6267d3dff39b80c96f5ae8a41c7e2dfc7bf2a286aa1 view view--labs"> <div class="views-view-grid view--labs cols-4"> <article class="node lab teaser"> <a href="/dept/mo/labs/aparicio-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Sam%20Aparicio.jpg?itok=2eFD7psC" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/aparicio-lab" rel="bookmark" ><span>Aparicio Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/benard-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-07/DSC09247.jpg?itok=pR2_8Tm8" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/benard-lab" rel="bookmark" ><span>Bénard Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/huntsman-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/David%20Huntsman.jpg?itok=QlyuncJ5" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/huntsman-lab" rel="bookmark" ><span>Huntsman Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/lin-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Kuo-Shyan%20Lin.jpg?itok=r1LKGqyE" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/lin-lab" rel="bookmark" ><span>Lin Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/park-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-05/DSC00088-min.jpg?itok=iEOK-h7k" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/park-lab" rel="bookmark" ><span>Park Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/roth-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Andrew%20Roth.jpg?itok=-ITfQ9_O" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/roth-lab" rel="bookmark" ><span>Roth Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/schrader-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Intan%20Schrader.jpg?itok=m4zqBWxp" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/schrader-lab" rel="bookmark" ><span>Schrader Lab</span> </a> </h2> </article> <article class="node lab teaser"> <a href="/dept/mo/labs/sorensen-lab"><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-08/DSC00160.jpg?itok=ITnownWp" width="580" height="460" alt="" /> </figure> </a> <h2 class="node__title"> <a href="/dept/mo/labs/sorensen-lab" rel="bookmark" ><span>Sorensen Lab</span> </a> </h2> </article> </div> </div> </div> </section> <section class="views-element-container block block--views-blockpublications-block-1 block--recent-publications block-views-block-publications-block-1" id="block-views-block-publications-block-1"> <h2 class="section__title">Recent Publications</h2> <div><div class="js-view-dom-id-12c3f6b2c10f37339ee834cb4bc442515f61aa217f68e0745c1a4abeb8e3ec45 view view--publications"> <div class="views-view-grid view--publications cols-3"> <article> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37846480" target="_blank" rel="bookmark"><span>The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes</span> </a></p> <div class="field field--field_journal">EMBO reports</div> <div class="field field--field_authors">Turgu B, El-Naggar A, Kogler M, Tortola L, Zhang HF, Hassan M, Lizardo MM, Kung SH, Lam W, Penninger JM, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37846480" target="_blank">Learn More</a></div> </article> <article> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37812652" target="_blank" rel="bookmark"><span>Surface and global proteome analyses identify ENPP1 and other surface proteins as actionable immunotherapeutic targets in Ewing sarcoma</span> </a></p> <div class="field field--field_journal">Clinical Cancer Research</div> <div class="field field--field_authors">Mooney B, Negri GL, Shyp T, Delaidelli A, Zhang HF, Spencer Miko SE, Weiner AK, Radaoui AB, Shraim R, Lizardo MM, Hughes CS, Li A, El-Naggar AM, Rouleau M, Li W, Dimitrov DS, Kurmasheva RT, Houghton PJ, Diskin SJ, Maris JM, Morin GB, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37812652" target="_blank">Learn More</a></div> </article> <article> <p class="node__title"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37611092" target="_blank" rel="bookmark"><span>A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma</span> </a></p> <div class="field field--field_journal">Science Advances</div> <div class="field field--field_authors">Zhang HF, Delaidelli A, Javed S, Turgu B, Morrison T, Hughes CS, Yang X, Pachva M, Lizardo MM, Singh G, Hoffmann J, Huang YZ, Patel K, Shraim R, Kung SHY, Morin GB, Aparicio S, Martinez D, Maris JM, Bosse KR, Williams KC, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37611092" target="_blank">Learn More</a></div> </article> </div> <nav role="navigation" aria-labelledby="pagination-heading"> <h4 class="visually-hidden">Pagination</h4> <ul class="js-pager__items pager__items mini"> <li> <a href="/dept/mo/molecular-oncology?page=1" title="Go to next page" rel="next"> <span class="visually-hidden">Next page</span> <span aria-hidden="true">››</span> </a> </li> </ul> </nav> </div> </div> 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