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src="//a.academia-assets.com/images/s65_no_pic.png" />Juan Sandoval</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2006, Biochemical Journal</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":43806931,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14885768/Id2_leaves_the_chromatin_of_the_E2F4_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":43806931,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14885768/Id2_leaves_the_chromatin_of_the_E2F4_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration"}"><span class="material-symbols-outlined" style="font-size: 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href="https://www.academia.edu/10640956/Id2_leaves_the_chromatin_of_the_E24_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration">Id2 leaves the chromatin of the E24–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26008368" href="https://independent.academia.edu/juansandoval25">juan sandoval</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Id2 leaves the chromatin of the E24–p130-controlled c-myc promoter during hepatocyte priming for liver 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The authors undertook a review of scientific publications with a focus on the liver regeneration.The cellular processes involved in liver regeneration require multiple systematic actions related to cytokines and growth factors. These interactions result in the initiation of mitogenic potential of the hepatocytes. The action of these modulators in the regenerative process require a processing in the extra-cellular matrix. Serines and metal proteins are responsible for the bio availability of cytokines and growth factors so that they can interact as receptors in the cellular membrane generating signaling events for the beginning and end of the liver regenerative process. The exact mechanism of interaction between cells, cytokines and growth factors is not well established yet. A series of ordered events that result in the hepatic tissue regeneration has been described. The better understanding of these interactions should provide a new approach of the treatment for liver diseases, aiming at inducing the regenerative process.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A molecular view of liver regeneration","attachmentId":49140177,"attachmentType":"pdf","work_url":"https://www.academia.edu/5787009/A_molecular_view_of_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5787009/A_molecular_view_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="81384309" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration">Molecular biology of liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55720677" href="https://independent.academia.edu/JSobczak1">J. Sobczak</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimie, 1986</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular biology of liver regeneration","attachmentId":87445384,"attachmentType":"pdf","work_url":"https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="85295266" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85295266/Signals_and_cells_involved_in_regulating_liver_regeneration">Signals and cells involved in regulating liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="228778049" href="https://independent.academia.edu/GeorgeMichalopoulos5">George Michalopoulos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cells, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and their receptors (MET and EGFR). In addition multiple cytokines and other signaling molecules contribute to the orchestration of a signal which drives hepatocytes into DNA synthesis. The other cell types of the liver receive and transmit to hepatocytes complex signals so that, in the end of the regenerative process, complete hepatic tissue is assembled and regeneration is terminated at the proper time and at the right liver size. 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In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated hepatocytes. We have studied Id-i expression in proliferating hepatocytes using an in vivo model of liver regeneration after partial hepatectomy and an in vitro growth factor stimulated hepatocyte culture system. Strong activation of Id-i was oh served in mid-late G1 of the hepatocyte cell cycle at a time corresponding to a mitogen restriction point. These observations suggest that Id-i is involved in the control of proliferation and differentiation in liver cells. tissues and cells of mesodermal origin. To gain insight into the potential role of Id proteins in proliferation and differentiation of endoderm-derived tissues, we determined the expression of the Id-i gene in rat liver in relation to hepatocyte proliferation and differen tiation...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Expression of Helix-Loop-Helix Factor Id-i Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture1","attachmentId":41368374,"attachmentType":"pdf","work_url":"https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="5787008" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5787008/Cellular_aspects_of_liver_regeneration">Cellular aspects of liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8467246" href="https://independent.academia.edu/JulianaFerreira9">Juliana Ferreira</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Cirurgica Brasileira, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">This paper has the objective to analyze the cellular aspects of liver regeneration (LR). Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a bypotential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocitic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. 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href="https://www.academia.edu/5787008/Cellular_aspects_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="79443890" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79443890/New_insights_into_liver_regeneration">New insights into liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34425522" href="https://independent.academia.edu/H%C3%A9l%C3%A8neGilgenkrantz">Hélène Gilgenkrantz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"New insights into liver regeneration","attachmentId":86156877,"attachmentType":"pdf","work_url":"https://www.academia.edu/79443890/New_insights_into_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/79443890/New_insights_into_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="101056348" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101056348/Modulation_of_the_Gene_Network_Connected_to_Interferon_%CE%B3_in_Liver_Regeneration_from_Oval_Cells">Modulation of the Gene Network Connected to Interferon-γ in Liver Regeneration from Oval Cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43593595" href="https://independent.academia.edu/SnorriThorgeirsson">Snorri Thorgeirsson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American Journal of Pathology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Modulation of the Gene Network Connected to Interferon-γ in Liver Regeneration from Oval Cells","attachmentId":101701341,"attachmentType":"pdf","work_url":"https://www.academia.edu/101056348/Modulation_of_the_Gene_Network_Connected_to_Interferon_%CE%B3_in_Liver_Regeneration_from_Oval_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101056348/Modulation_of_the_Gene_Network_Connected_to_Interferon_%CE%B3_in_Liver_Regeneration_from_Oval_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="12699438" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12699438/Cellular_aspects_of_liver_regeneration1">Cellular aspects of liver regeneration1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31718557" href="https://usp-br.academia.edu/FernandoRamalho">Fernando Ramalho</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Cirurgica …, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">1. Study performed in the Laboratory of Cellular Proliferation of the Department of Pathology of the Faculty of Medicine of Ribeirão Preto, University of São Paulo, (FMRPUSP), Brazil. 2. Fellow PhD degree of the Department of Pathology, (FMRP-USP), Brazil. 3. PhD, ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cellular aspects of liver regeneration1","attachmentId":45999436,"attachmentType":"pdf","work_url":"https://www.academia.edu/12699438/Cellular_aspects_of_liver_regeneration1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12699438/Cellular_aspects_of_liver_regeneration1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="92144495" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings">Studying Liver Regeneration by Means of Molecular Biology: How Far We Are in Interpreting the Findings?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="89129603" href="https://independent.academia.edu/MartinBuncek">Martin Buncek</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Medica (Hradec Kralove, Czech Republic), 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Liver regeneration in mammals is a unique phenomenon attracting scientific interest for decades. It is a valuable model for basic biology research of cell cycle control as well as for clinically oriented studies of wide and heterogeneous group of liver diseases. This article provides a concise review of current knowledge about the liver regeneration, focusing mainly on rat partial hepatectomy model. The three main recognized phases of the regenerative response are described. The article also summarizes history of molecular biology approaches to the topic and finally comments on obstacles in interpreting the data obtained from large scale microarray-based gene expression analyses.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Studying Liver Regeneration by Means of Molecular Biology: How Far We Are in Interpreting the Findings?","attachmentId":95232349,"attachmentType":"pdf","work_url":"https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":43806931,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":43806931,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_43806931" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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