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{"work":{"id":12699438,"created_at":"2015-05-31T05:44:31.952-07:00","from_world_paper_id":137073457,"updated_at":"2021-01-14T22:45:14.118-08:00","_data":{"abstract":"1. Study performed in the Laboratory of Cellular Proliferation of the Department of Pathology of the Faculty of Medicine of Ribeirão Preto, University of São Paulo, (FMRPUSP), Brazil. 2. Fellow PhD degree of the Department of Pathology, (FMRP-USP), Brazil. 3. PhD, ...","publisher":"SciELO Brasil","publication_date":"2006,,","publication_name":"Acta Cirurgica …"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Cellular aspects of liver regeneration1","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [31718557]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":45999436,"attachmentType":"pdf"}"><img alt="First page of “Cellular aspects of liver regeneration1”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/45999436/mini_magick20190210-5546-1psx7n.png?1549851022" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Cellular aspects of liver regeneration1</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="31718557" href="https://usp-br.academia.edu/FernandoRamalho"><img alt="Profile image of Fernando Ramalho" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Fernando Ramalho</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2006, Acta Cirurgica …</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">4 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 12699438; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=12699438"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">1. Study performed in the Laboratory of Cellular Proliferation of the Department of Pathology of the Faculty of Medicine of Ribeirão Preto, University of São Paulo, (FMRPUSP), Brazil. 2. Fellow PhD degree of the Department of Pathology, (FMRP-USP), Brazil. 3. PhD, ...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":45999436,"attachmentType":"pdf","workUrl":"https://www.academia.edu/12699438/Cellular_aspects_of_liver_regeneration1"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":45999436,"attachmentType":"pdf","workUrl":"https://www.academia.edu/12699438/Cellular_aspects_of_liver_regeneration1"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas" data-impression-entity-id="12699438" data-impression-entity-type="2" data-impression-source="signup-banner"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Upon damage in this organ, the regenerative capacity of hepatocyte is sufficiently able to reestablish the parenchyma as a whole. Taking into account the regenerative capacity of hepatocyte, the need of a progenitor or a liver trunk cell was not obvious. Nowadays it is well-established that precursor cells take part in the liver regenerative process. The liver trunk cell, oval cell, acts as a bypotential precursor, contributing for the liver restoration, mainly when the hepatocytes are unable to proliferate. Another precursor, trunk cell of hematopoetic origin (HSC), takes part in the regenerative process, originating cells of the hepatocitic lineage and colangiocytes, as well as the oval cell. The way the trans-differentiation takes place is not established yet. A number of studies must be undertaken in order to clarify questions, such as the possible occurrence of cellular fusion process between the HSC and the hepatic cells and the possibility of application as a new therapeutic procedure in the treatment of diseases associated with insufficiency of this noble organ.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cellular aspects of liver regeneration","attachmentId":49140167,"attachmentType":"pdf","work_url":"https://www.academia.edu/5787008/Cellular_aspects_of_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5787008/Cellular_aspects_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="81384309" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration">Molecular biology of liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55720677" href="https://independent.academia.edu/JSobczak1">J. Sobczak</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimie, 1986</p><p class="ds-related-work--abstract ds2-5-body-sm">Liver regeneration is a good system for studying cell proliferation in an in vivo, physiologically controlled situation. Various hepatotrophic factors, neuromediators, hormones and growth factors, presumably acting in synergy, seem necessary to induce the switch from quiescence to proliferation. As a consequence of this activation, a number of changes occurs in the hepatocyte: (I) modifications of the plasma membrane proteins; (II) metabolic changes such as variations in albumin and fibrinogen concentrations, and induction of the acute phase proteins; (III) induction of several specific mRNAs; (IV) variations in cAMP concentrations, and consequently in the activity of protein kinases and several other enzymes; (V) modifications in chromosomal proteins; (VI) induction of proteins involved in DNA replication. A model has been constructed which is more a basis for reflexion than a theoretical model. It takes ' into account the possible connections between the 'different molecular events cited above. It is hypothesized that DNA replication is at least partly uncoupled from mitosis, and that the initial events of the proliferative response may be triggered by nutritional elements. rat liver / hepatic regeneration / DNA replication / mitosis / cell proliferation Resume-Biologie moleculaire de la regeneration hepatique, La regeneration hepatique apres une hepatectomie partielle a ete longuement etudiee d'un point de vue physiologique. Quelques facteurs hepatotrophiques (hormones, neuromediateurs, facteurs protetques) ont ete identifies, mais les apports recents de la biologie moleculaire permettent de mieux comprendre les evenements qui precedent 10 replication et fa mitose. Au cours de la regeneration, bien que toutes les fonctions differenciees de fa cellule hepatique soient maintenues, son metabolisme est affecte (en particulier la synthese d'albumine, de fibrinogene et des proteines de stress). Le role de l'AMPc se degage clairement: it est necessaire pour que fa synthese d'ADN ail lieu; it active les proteines kinases AMPc dependantes qui, apres translocation du cytoplasme vers Ie noyau , phosphorylent les proteines chromatiniennes, dont I'histone Hl. D'autres evenements ont ete decrits: activation de pro Mines appartenant au complexe de replication, modification de proteines membran aires, augmentation du niveau de certains ARN messagers (parmi lesquels des oncogenes). Par ai/leurs, il apparait que dans ce systeme, la replication peut eIre decouplee de 10 mitose. Tous ces elements sont integres dans un schema final qui se veut etre davantage une base de reflexion qu 'un modele theorique du controle de la multiplication cellulaire. regeneration hepatique / proliferation cellulaire / mitose I joie de rat .. This article is dedicated to th e memory of J .M. Sala-Trepat.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular biology of liver regeneration","attachmentId":87445384,"attachmentType":"pdf","work_url":"https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81384309/Molecular_biology_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="5787009" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5787009/A_molecular_view_of_liver_regeneration">A molecular view of liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8467246" href="https://independent.academia.edu/JulianaFerreira9">Juliana Ferreira</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Cirurgica Brasileira, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">The purpose of this review was to carry out an analysis of the liver regenerative process focusing on the molecular interactions involved in this process. The authors undertook a review of scientific publications with a focus on the liver regeneration.The cellular processes involved in liver regeneration require multiple systematic actions related to cytokines and growth factors. These interactions result in the initiation of mitogenic potential of the hepatocytes. The action of these modulators in the regenerative process require a processing in the extra-cellular matrix. Serines and metal proteins are responsible for the bio availability of cytokines and growth factors so that they can interact as receptors in the cellular membrane generating signaling events for the beginning and end of the liver regenerative process. The exact mechanism of interaction between cells, cytokines and growth factors is not well established yet. A series of ordered events that result in the hepatic tissue regeneration has been described. The better understanding of these interactions should provide a new approach of the treatment for liver diseases, aiming at inducing the regenerative process.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A molecular view of liver regeneration","attachmentId":49140177,"attachmentType":"pdf","work_url":"https://www.academia.edu/5787009/A_molecular_view_of_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5787009/A_molecular_view_of_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="123735787" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123735787/The_natural_history_of_liver_regeneration_in_rats_Description_of_an_animal_model_for_liver_regeneration_studies">The natural history of liver regeneration in rats: Description of an animal model for liver regeneration studies</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="317083195" href="https://independent.academia.edu/KasperAndersen32">Kasper Andersen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Surgery, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Rodent models have been used to evaluate aspects of liver regeneration. The aim of the present study was to investigate the natural history of liver regeneration in healthy rats. Methods: A 70% partial hepatectomy was performed in 64 rats. The animals were randomised into 8 groups and evaluated on postoperative days one to eight. Hepatocyte proliferation was evaluated by immunohistochemistry using unbiased stereological principles. Results: The mean rat body weight was 238 g (211e287). The mean weight of the resected liver was 6.3 g (5.2e7.3) and the estimated mean total liver weight was 8.9 g (7.4e10.4). Both liver weight analysis and regeneration rate showed an ascending curve, with a maximum slope on postoperative days 1e4, reaching a steady state on days 5e8. Hepatocyte proliferation (positive Ki-67 cell profiles pr. mm 2 ) was high (250 cell profiles/mm 2 ) on postoperative days 1e3 and tapered off on day 5. Conclusion: Seventy percent partial hepatectomy in healthy rats induces a rapid regenerative response and PODs 2, 4 and 8 seems optimal for assessing hepatic growth in future studies.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The natural history of liver regeneration in rats: Description of an animal model for liver regeneration studies","attachmentId":118098224,"attachmentType":"pdf","work_url":"https://www.academia.edu/123735787/The_natural_history_of_liver_regeneration_in_rats_Description_of_an_animal_model_for_liver_regeneration_studies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123735787/The_natural_history_of_liver_regeneration_in_rats_Description_of_an_animal_model_for_liver_regeneration_studies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="5350001" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5350001/Mechanisms_of_reparative_regeneration_of_the_pathologically_changed_liver">Mechanisms of reparative regeneration of the pathologically changed liver</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7416825" href="https://uin-suska.academia.edu/BartonAlbino">Barton Albino</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Bulletin of Experimental Biology and Medicine, 1973</p><p class="ds-related-work--abstract ds2-5-body-sm">Restoration of the normal parenchyma during reparative regeneration of the liver was studied by histological, cytological, biochemical, and immunochemical methods in rats with experimental cirrhosis and hepatitis. Analysis of the mitotic activity of the hepatocytes, the dynamics of the change in the number of binuclear cells, and the change in size and ploidy of the mononuclear hepatocytes revealed some general and specific rules governing reparative regeneration and the reversibility of the pathological changes in these conditions. Somatic polyploidization is suggested as playing an essential role in the reparative regeneration of the pathologically changed liver.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mechanisms of reparative regeneration of the pathologically changed liver","attachmentId":49330787,"attachmentType":"pdf","work_url":"https://www.academia.edu/5350001/Mechanisms_of_reparative_regeneration_of_the_pathologically_changed_liver","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5350001/Mechanisms_of_reparative_regeneration_of_the_pathologically_changed_liver"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="79443890" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79443890/New_insights_into_liver_regeneration">New insights into liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34425522" href="https://independent.academia.edu/H%C3%A9l%C3%A8neGilgenkrantz">Hélène Gilgenkrantz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Even if the Greeks probably anticipated rather than discovered the extraordinary regenerative capacity of the liver with the Prometheus myth, this phenomenon still fascinates scientists nowadays with the same enthusiasm. There are good reasons to decipher this process other than to find an answer to our fantasy of immortality: it could indeed help patients needing large liver resections or living-donor liver transplantation, it could increase our understanding of liver pathology and finally it could enable novel cell-therapy approaches. For decades, most of our knowledge about the mechanisms involved in liver regeneration came from the classic twothirds partial hepatectomy (PH) model. In this scenario, hepatocytes play the leading role, which raises the question of the simple existence of a stem cell population. Recently however, hepatic progenitor cells come again under the limelight, seeming to play a role in liver physiology and in various liver diseases such as steatosis or cirrhosis. Excellent reviews have recently addressed liver regeneration. Our goal is therefore to focus on recent improvements in the field, highlighting data mostly published in the last two years in order to draw a putative picture of what the future research axes on liver regeneration might look like.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"New insights into liver regeneration","attachmentId":86156877,"attachmentType":"pdf","work_url":"https://www.academia.edu/79443890/New_insights_into_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/79443890/New_insights_into_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="85295262" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85295262/Liver_regeneration_Alternative_epithelial_pathways">Liver regeneration: Alternative epithelial pathways</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="228778049" href="https://independent.academia.edu/GeorgeMichalopoulos5">George Michalopoulos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The International Journal of Biochemistry &amp; Cell Biology, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Loss of hepatic tissue triggers a regenerative response in the whole organ. Under typical normal conditions, all hepatic cells (epithelial: hepatocytes and biliary epithelial cells; non-epithelial: stellate cells, macrophages and endothelial cells) undergo one to three rounds of replication to establish the original number of cells and restore organ size. The review summarizes the literature of regenerative patterns in situations in which proliferation of either hepatocytes or biliary epithelial cells is inhibited. The evidence strongly suggests that under these circumstances, hepatocytes or biliary epithelial cells can function as facultative stem cells for each other and replenish the inhibited cellular compartment by a process of trans-differentiation, involving complex signaling pathways. These pathways are activated under experimental conditions in rodents and in fulminant hepatitis associated with liver failure in humans. Mechanistic analysis of these pathways has implications for liver biology and for potential therapeutic modalities in human liver disease.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Liver regeneration: Alternative epithelial pathways","attachmentId":90036132,"attachmentType":"pdf","work_url":"https://www.academia.edu/85295262/Liver_regeneration_Alternative_epithelial_pathways","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85295262/Liver_regeneration_Alternative_epithelial_pathways"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="92144495" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings">Studying Liver Regeneration by Means of Molecular Biology: How Far We Are in Interpreting the Findings?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="89129603" href="https://independent.academia.edu/MartinBuncek">Martin Buncek</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Medica (Hradec Kralove, Czech Republic), 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Liver regeneration in mammals is a unique phenomenon attracting scientific interest for decades. It is a valuable model for basic biology research of cell cycle control as well as for clinically oriented studies of wide and heterogeneous group of liver diseases. This article provides a concise review of current knowledge about the liver regeneration, focusing mainly on rat partial hepatectomy model. The three main recognized phases of the regenerative response are described. The article also summarizes history of molecular biology approaches to the topic and finally comments on obstacles in interpreting the data obtained from large scale microarray-based gene expression analyses.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Studying Liver Regeneration by Means of Molecular Biology: How Far We Are in Interpreting the Findings?","attachmentId":95232349,"attachmentType":"pdf","work_url":"https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92144495/Studying_Liver_Regeneration_by_Means_of_Molecular_Biology_How_Far_We_Are_in_Interpreting_the_Findings"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="84950370" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84950370/Revisiting_the_liver_from_development_to_regeneration_what_we_ought_to_know_">Revisiting the liver: from development to regeneration - what we ought to know!</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35486159" href="https://independent.academia.edu/IsabelFabregat">Isabel Fabregat</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The International Journal of Developmental Biology, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">The liver is structurally and functionally heterogeneous and complex, and it accomplishes crucial functions for the organism. Its most remarkable potential is its capacity to regenerate after injury in order to maintain whole body homeostasis and guarantee the survival of the individual. Under normal conditions, liver regeneration (LR) is attributed to adult hepatocytes, the main cells in the liver which are able to proliferate in response to different stimuli or injuries. Nevertheless, when liver injury is severe and/or hepatocytes are prevented from proliferation, liver stem/progenitor cells (LS/PCs) participate directing LR to maintain liver mass and functions. Different mechanisms have been shown to guide this second line of LR, such as intrahepatic and extrahepatic liver progenitor cells, as well as transdifferentiation processes between hepatocytes and other liver cells. For this reason, many efforts have been made to elucidate the specific molecular mechanisms which orchestrate this process; this in turn would improve the prognosis and treatment of liver diseases. In this review, we revisit the fascinating process of LR, also with a short overview about liver development, the process from which arises the concept of LS/PCs participating in LR, and very important nowadays when considering cell therapy and tissue bioengineering for the treatment of patients suffering from liver disease.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Revisiting the liver: from development to regeneration - what we ought to know!","attachmentId":89801717,"attachmentType":"pdf","work_url":"https://www.academia.edu/84950370/Revisiting_the_liver_from_development_to_regeneration_what_we_ought_to_know_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/84950370/Revisiting_the_liver_from_development_to_regeneration_what_we_ought_to_know_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="23512917" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23512917/Liver_Regeneration_Is_an_Angiogenesis_Associated_Phenomenon">Liver Regeneration Is an Angiogenesis- Associated Phenomenon</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45522513" href="https://independent.academia.edu/RitchieEwan">Ewan Ritchie</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Annals of Surgery, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">To investigate whether liver regeneration is an angiogenesisassociated phenomenon.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Liver Regeneration Is an Angiogenesis- Associated Phenomenon","attachmentId":43948793,"attachmentType":"pdf","work_url":"https://www.academia.edu/23512917/Liver_Regeneration_Is_an_Angiogenesis_Associated_Phenomenon","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23512917/Liver_Regeneration_Is_an_Angiogenesis_Associated_Phenomenon"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":45999436,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":45999436,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_45999436" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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proliferation","attachmentId":39923057,"attachmentType":"pdf","work_url":"https://www.academia.edu/18188605/Analytical_methods_for_the_study_of_liver_cell_proliferation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/18188605/Analytical_methods_for_the_study_of_liver_cell_proliferation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="115624148" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115624148/Liver_regeneration_the_best_kept_secret_A_model_of_tissue_injury_response">Liver regeneration--the best kept secret. 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rat","attachmentId":41215171,"attachmentType":"pdf","work_url":"https://www.academia.edu/20239358/Extracellular_matrix_remodeling_at_the_early_stages_of_liver_regeneration_in_the_rat","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/20239358/Extracellular_matrix_remodeling_at_the_early_stages_of_liver_regeneration_in_the_rat"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="85295254" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85295254/Liver_regeneration">Liver regeneration</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="228778049" href="https://independent.academia.edu/GeorgeMichalopoulos5">George Michalopoulos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cellular Physiology, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Liver regeneration","attachmentId":90036128,"attachmentType":"pdf","work_url":"https://www.academia.edu/85295254/Liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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data-collection-position="7" data-entity-id="25330829" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25330829/Effect_of_Molecular_Therapeutics_on_Liver_Regeneration_in_a_Murine_Model">Effect of Molecular Therapeutics on Liver Regeneration in a Murine Model</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45771235" href="https://independent.academia.edu/fanfan20">fan fan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Oncology, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Molecular Therapeutics on Liver Regeneration in a Murine 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href="https://www.academia.edu/101560209/A_Model_of_Liver_Regeneration">A Model of Liver Regeneration</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="269126061" href="https://independent.academia.edu/LeonFurchtgott">Leon Furchtgott</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biophysical Journal, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Model of Liver Regeneration","attachmentId":102068455,"attachmentType":"pdf","work_url":"https://www.academia.edu/101560209/A_Model_of_Liver_Regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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data-author-id="42442502" href="https://independent.academia.edu/JiHuaShi">Ji-Hua Shi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Liver Transplantation, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Growth of hepatocellular carcinoma in the regenerating liver","attachmentId":41711736,"attachmentType":"pdf","work_url":"https://www.academia.edu/21093886/Growth_of_hepatocellular_carcinoma_in_the_regenerating_liver","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21093886/Growth_of_hepatocellular_carcinoma_in_the_regenerating_liver"><span 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href="https://independent.academia.edu/AnnaDiehl">Anna Diehl</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Regulation of signal transduction during liver regeneration","attachmentId":38831918,"attachmentType":"pdf","work_url":"https://www.academia.edu/15939556/Regulation_of_signal_transduction_during_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15939556/Regulation_of_signal_transduction_during_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="33594117" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33594117/Stem_Cells_and_Liver_Regeneration">Stem Cells and Liver Regeneration</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65765705" href="https://independent.academia.edu/CraigDorrell">Craig Dorrell</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65805076" href="https://independent.academia.edu/AlessandraDuncan">ANDREW Duncan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Gastroenterology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="73843819" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73843819/Hepatic_regeneration_If_it_aint_broke_dont_fix_it">Hepatic regeneration: If it ain't broke, don't fix it</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="60056066" href="https://independent.academia.edu/GeraldMinuk">Gerald Minuk</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatic regeneration: If it ain't broke, don't fix 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