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In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1" /> <meta property="og:title" content="Expression of Helix-Loop-Helix Factor Id-i Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture1" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Id proteins are known as negative regulators of differentiation in various cell types. In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated" /> <meta property="article:author" content="https://independent.academia.edu/FacsBd" /> <meta name="description" content="Id proteins are known as negative regulators of differentiation in various cell types. In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated" /> <title>(PDF) Expression of Helix-Loop-Helix Factor Id-i Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture1</title> <link rel="canonical" href="https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '8a116c19e8726d72e5f38e985ded30eabdbede04'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1740531413000); window.Aedu.timeDifference = new Date().getTime() - 1740531413000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Id proteins are known as negative regulators of differentiation in various cell types. In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated hepatocytes. We have studied Id-i expression in proliferating hepatocytes using an in vivo model of liver regeneration after partial hepatectomy and an in vitro growth factor stimulated hepatocyte culture system. Strong activation of Id-i was oh served in mid-late G1 of the hepatocyte cell cycle at a time corresponding to a mitogen restriction point. These observations suggest that Id-i is involved in the control of proliferation and differentiation in liver cells. tissues and cells of mesodermal origin. To gain insight into the potential role of Id proteins in proliferation and differentiation of endoderm-derived tissues, we determined the expression of the Id-i gene in rat liver in relation to hepatocyte proliferation and differen tiation...","author":[{"@context":"https://schema.org","@type":"Person","name":"Facs Bd","url":"https://independent.academia.edu/FacsBd"}],"contributor":[],"dateCreated":"2016-01-21","headline":"Expression of Helix-Loop-Helix Factor Id-i Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture1","image":"https://attachments.academia-assets.com/41368374/thumbnails/1.jpg","inLanguage":"en","keywords":["Cell Cycle","Gene expression","Liver regeneration","Partial Hepatectomy","Growth 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In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated hepatocytes. We have studied Id-i expression in proliferating hepatocytes using an in vivo model of liver regeneration after partial hepatectomy and an in vitro growth factor stimulated hepatocyte culture system. Strong activation of Id-i was oh served in mid-late G1 of the hepatocyte cell cycle at a time corresponding to a mitogen restriction point. These observations suggest that Id-i is involved in the control of proliferation and differentiation in liver cells. tissues and cells of mesodermal origin. To gain insight into the potential role of Id proteins in proliferation and differentiation of endoderm-derived tissues, we determined the expression of the Id-i gene in rat liver in relation to hepatocyte proliferation and differen tiation...","ai_title_tag":"Id-i Expression in Rat Liver: Proliferation and Differentiation"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Expression of Helix-Loop-Helix Factor Id-i Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture1","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [41851109]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; 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In this report, we show that the Id-i gene was down regulated during the development of rat liver. No Id-i transcripts were detected in terminal differentiated hepatocytes. We have studied Id-i expression in proliferating hepatocytes using an in vivo model of liver regeneration after partial hepatectomy and an in vitro growth factor stimulated hepatocyte culture system. Strong activation of Id-i was oh served in mid-late G1 of the hepatocyte cell cycle at a time corresponding to a mitogen restriction point. These observations suggest that Id-i is involved in the control of proliferation and differentiation in liver cells. tissues and cells of mesodermal origin. To gain insight into the potential role of Id proteins in proliferation and differentiation of endoderm-derived tissues, we determined the expression of the Id-i gene in rat liver in relation to hepatocyte proliferation and differen tiation...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":41368374,"attachmentType":"pdf","workUrl":"https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":41368374,"attachmentType":"pdf","workUrl":"https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas" data-impression-entity-id="20432925" data-impression-entity-type="2" data-impression-source="signup-banner"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="41368374" data-landing_url="https://www.academia.edu/20432925/Expression_of_Helix_Loop_Helix_Factor_Id_i_Is_Dependent_on_the_Hepatocyte_Proliferation_and_Differentiation_Status_in_Rat_Liver_and_in_Primary_Culture1" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="10640956" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/10640956/Id2_leaves_the_chromatin_of_the_E24_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration">Id2 leaves the chromatin of the E24–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="26008368" href="https://independent.academia.edu/juansandoval25">juan sandoval</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Id2 leaves the chromatin of the E24–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration","attachmentId":47241404,"attachmentType":"pdf","work_url":"https://www.academia.edu/10640956/Id2_leaves_the_chromatin_of_the_E24_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" 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priming for liver regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33865365" href="https://independent.academia.edu/JuanSandoval48">Juan Sandoval</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Id2 leaves the chromatin of the E2F4–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration","attachmentId":43806931,"attachmentType":"pdf","work_url":"https://www.academia.edu/14885768/Id2_leaves_the_chromatin_of_the_E2F4_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14885768/Id2_leaves_the_chromatin_of_the_E2F4_p130_controlled_c_myc_promoter_during_hepatocyte_priming_for_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="26528800" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26528800/TGF_%CE%B21_induced_cell_growth_arrest_and_partial_differentiation_is_related_to_the_suppression_of_Id1_in_human_hepatoma_cells">TGF-β1-induced cell growth arrest and partial differentiation is related to the suppression of Id1 in human hepatoma cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50495672" href="https://independent.academia.edu/YutakaTakeda">Yutaka Takeda</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Oncology Reports, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Transforming growth factor beta 1 (TGF-ß1) is a proposed regulator of Ids (inhibitors of DNA binding/differentiation) gene expression in epithelial cells. We previously reported that Id proteins are variously expressed in human hepatocellular carcinomas (HCC). However, the mechanism of regulation of Ids in HCC remains obscure. Here, we examined the relationship between Id1 and TGF-ß1 in four HCC cell lines, and studied the changes in cell proliferation, cell cycle and differentiation. The four HCC cell lines expressed Id1, TGF-ß1 and their receptors at various levels. TGF-ß1 strongly inhibited the growth of HuH7 cells, while the growth inhibition was moderate in PLC/PRF/5, and was not observed in HLE and HLF cell lines. TGF-ß1-induced growth inhibition in HuH7 cells was associated with cell accumulation in the G1 phase and partial induction of differentiation (with reduction of AFP and AFP-L3). Induction by TGF-ß1 dose-dependently suppressed Id1 expression in HuH7 cells; 1 ng/ml TGF-ß1 inhibited Id1 by 84.0 and 78.6% that of the untreated control at transcriptional and protein levels, respectively. HLE and HLF cells, which did not exhibit a TGF-ß1 growth inhibitory effect, lacked TGF-ß receptors and Id1 expression was not altered. In PLC/PRF/ 5 cells, Id1 augmentation was not observed in response to TGF-ß1, indicating that TGF-ß1induced growth inhibition was not related to Id1 in this cell line. Our results suggest that, in some HCC cells, the pathway of suppression of Id1 by TGF-ß1 may be important in TGF-ß1-induced growth inhibition and partial differentiation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"TGF-β1-induced cell growth arrest and partial differentiation is related to the suppression of Id1 in human hepatoma cells","attachmentId":46824199,"attachmentType":"pdf","work_url":"https://www.academia.edu/26528800/TGF_%CE%B21_induced_cell_growth_arrest_and_partial_differentiation_is_related_to_the_suppression_of_Id1_in_human_hepatoma_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26528800/TGF_%CE%B21_induced_cell_growth_arrest_and_partial_differentiation_is_related_to_the_suppression_of_Id1_in_human_hepatoma_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="44983993" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/44983993/Gene_regulation_in_rodent_hepatocytes_during_development_differentiation_and_disease">Gene regulation in rodent hepatocytes during development, differentiation and disease</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="89761205" href="https://unil.academia.edu/JovanMirkovitch">Jovan Mirkovitch</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Biochemistry, 1993</p><p class="ds-related-work--abstract ds2-5-body-sm">The expression of genes in the liver is mostly controlled at the transcriptional level and depends on the regulatory interactions between cis-acting sequences and trans-acting molecules. Proximal promoters and distant enhancers in combination with a number of hepatocyte-enriched DNA-binding proteins and general transcription factors interact specifically with these elements and control the expression of liver-specific genes. Hepatocyte-enriched regulatory proteins have been isolated from liver nuclear extracts, characterized, and their corresponding genes have been cloned. These include the hepatocyte nuclear factors 1, 3, 4 (HNF-1,3,4), some members of the CAAATIenhancer binding protein (CEBP) family, and D site binding protein (DBP). These factors belong to larger families and are able to form heterodimers, perhaps with the exception of the HNF-3 family, with other members of the same family. Interestingly, the majority of the genes encoding such proteins are themselves regulated at the transcriptional level, although both transcriptional and post-transcriptional events modulate their expression during development, hepatocyte differentiation and disease, suggesting that a transcriptional cascade may play a critical role in mammalian liver development and differentiation. Cellular proliferation and differentiation during development is controlled by many regulatory processes. These include the selective induction, expression and regulation of the activity of genes which are likely to encode for DNAbinding proteins or proteins that interact with them and control the transcription of several other genes. Thus a cascade of transcriptional activities is initiated that will direct development and differentiation to the adult phenotype [l -31. The study of liver development and differentiation offers many opportunities to address these questions at the molecular level. Rodent liver organogenesis has been thoroughly studied at the cellular level. It is now known that at day eight of embryonal development the endodermal cells of the developing foregut are induced by the precardiac mesenchyme and approximately one day later the hepatic endoderm will emerge from the gut endoderm. Subsequently the primary liver diverticulum invades the mesenchyme of the septum transversum. During this stage, proliferation and differentiation of the hepatic endoderm into hepatoblasts occurs.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Gene regulation in rodent hepatocytes during development, differentiation and disease","attachmentId":65524369,"attachmentType":"pdf","work_url":"https://www.academia.edu/44983993/Gene_regulation_in_rodent_hepatocytes_during_development_differentiation_and_disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/44983993/Gene_regulation_in_rodent_hepatocytes_during_development_differentiation_and_disease"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="60466763" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60466763/Phenotypic_characterization_of_rat_hepatoma_cell_lines_and_lineage_specific_regulation_of_gene_expression_by_differentiation_agents">Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32414826" href="https://unc.academia.edu/LolaReid">Lola Reid</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Differentiation, 1998</p><p class="ds-related-work--abstract ds2-5-body-sm">Hepatoma cell lines can be characterized by their expression of hepatocyte-and biliary-specific genes and by their response to differentiating agents in a lineage-dependent manner. These characteristics can be used to map the maturational lineage position of the cell lines. Tissue-specific gene expression and regulation by heparin, dimethylsulfoxide (DMSO), and sodium butyrate (SB) were examined in three rat hepatoma cell lines and two rat liver epithelial cell lines. Based on antigenic profiles and gene expression in serum-supplemented medium, the hepatoma cell lines could be organized in distinct categories of hepatic differentiation. All three hepatomas expressed the following five genes: γ-glutamyl transpeptidase (GGT), glutathione-S-transferase pi (Yp), glutamine synthetase, and α5 and β1 integrin. Cell line H 4 AzC 2 also expressed α-fetoprotein (AFP), albumin, IGF II receptor, and the biliary/oval cell antigens OC.2 and OC.3, a phenotype characteristic of fetal hepatocytes. FTO-2B cells lacked AFP, OC.2, and OC.3 but expressed albumin and IGF II receptor in addition to the five commonly expressed genes, consistent with a more hepatocyte-like phenotype. Cell line H5D.7 expressed neither albumin nor the IGF II receptor, but did express OC.2, OC.3, and α3 integrin in addition to the five commonly expressed genes, characteristic of biliary epithelial cells. Regulation of gene expression by heparin, DMSO, and SB was examined in cells cultured in hormonally defined medium. The patterns of regulation of AFP, albumin, GGT, and Yp were dependent upon the state of differentiation of the cell. FTO-2B cells regulated genes in a manner similar to that of E16 fetal hepatocytes, H 4 AzC 2 regulated genes characteristic of both hepatocytic and biliary lineages, and H5D.7 regulated only biliary genes. Suppression of GGT by DMSO was uniformly observed. The three cell lines expressed equal amounts of HNF-4, but FTO-2B cells expressed more HNF-3β and less HNF-3α, while the reverse was true of H 4 AzC 2 and H5D.7 cells.& b d y :</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents","attachmentId":73900555,"attachmentType":"pdf","work_url":"https://www.academia.edu/60466763/Phenotypic_characterization_of_rat_hepatoma_cell_lines_and_lineage_specific_regulation_of_gene_expression_by_differentiation_agents","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60466763/Phenotypic_characterization_of_rat_hepatoma_cell_lines_and_lineage_specific_regulation_of_gene_expression_by_differentiation_agents"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="18732520" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18732520/Ye_H_Holterman_AX_Yoo_KW_Franks_RR_Costa_RH_Premature_expression_of_the_winged_helix_transcription_factor_HFH_11B_in_regenerating_mouse_liver_accelerates_hepatocyte_entry_into_S_phase_Mol_Cell_Biol_19_8570_8580">Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH.. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 19: 8570-8580</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38798235" href="https://independent.academia.edu/HonggangYe">Honggang Ye</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular and Cellular Biology</p><p class="ds-related-work--abstract ds2-5-body-sm">Two-thirds partial hepatectomy (PH) induces differentiated cells in the liver remnant to proliferate and regenerate to its original size. The proliferation-specific HNF-3/fork head homolog-11B protein (HFH-11B; also known as Trident and Win) is a family member of the winged helix/fork head transcription factors and in regenerating liver its expression is reactivated prior to hepatocyte entry into DNA replication (S phase). To examine whether HFH-11B regulates hepatocyte proliferation during liver regeneration, we used the -3-kb transthyretin (TTR) promoter to create transgenic mice that displayed ectopic hepatocyte expression of HFH-11B. Liver regeneration studies with the TTR-HFH-11B mice demonstrate that its premature expression resulted in an 8-h acceleration in the onset of hepatocyte DNA replication and mitosis. This liver regeneration phenotype is associated with protracted expression of cyclin D1 and C/EBPbeta, which are involved in stimulating DNA replication and premature e...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH.. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 19: 8570-8580","attachmentId":40224769,"attachmentType":"pdf","work_url":"https://www.academia.edu/18732520/Ye_H_Holterman_AX_Yoo_KW_Franks_RR_Costa_RH_Premature_expression_of_the_winged_helix_transcription_factor_HFH_11B_in_regenerating_mouse_liver_accelerates_hepatocyte_entry_into_S_phase_Mol_Cell_Biol_19_8570_8580","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18732520/Ye_H_Holterman_AX_Yoo_KW_Franks_RR_Costa_RH_Premature_expression_of_the_winged_helix_transcription_factor_HFH_11B_in_regenerating_mouse_liver_accelerates_hepatocyte_entry_into_S_phase_Mol_Cell_Biol_19_8570_8580"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="71809454" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71809454/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1%CE%B1_and_1%CE%B2_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation">Nonparenchymal cells from regenerating rat liver generate interleukin‐1α and‐1β: A mechanism of negative regulation of hepatocyte proliferation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39700117" href="https://independent.academia.edu/ClareSelden">Clare Selden</a></div><p class="ds-related-work--metadata ds2-5-body-xs">…, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">role suppressing hepatocyte proliferation and terminating the Following experimental partial hepatectomy of 70% in the surge of DNA synthesis induced after partial hepatectomy. rat, there is a semisynchronized surge of hepatocyte prolifera-(HEPATOLOGY 1997;26:49-58.) tion that ceases after 48 to 72 hours. Little is known about the determinants governing the termination of the proliferative phase, although transforming growth factor (TGF) b has been The majority of hepatocytes in the adult liver are quiescent implicated as an important inhibitor of hepatocyte replication with respect to proliferation. In the rat, only 0.1% of hepatoin this model. We previously reported an additional noncyte nuclei are engaged in replicative DNA synthesis, and TGF-b inhibitor in medium conditioned by nonparenchymal the mitotic rate is 1 in 10,000; 1 figures for human liver are cells isolated from regenerating liver (CM-NPC-Reg) between similar. Adult hepatocytes remain capable of proliferation, 24 and 48 hours after partial hepatectomy, but it was not and, after injury, there is a prompt regenerative response that found in medium conditioned by nonparenchymal cells from recruits mature hepatocytes into the cell cycle. In the rat unoperated control liver. CM-NPC-Reg suppressed replicative after partial hepatectomy of 70%, cells enter the S phase DNA synthesis of primary rat hepatocytes in response to hepawithin 12 to 15 hours, and up to 40% of hepatocytes are in tocyte growth factor (HGF), epidermal growth factor (EGF), the S phase at the peak of DNA synthesis 24 hours after or TGF-a as assessed by 3 H-thymidine incorporation. We now resection. 2 At 30 hours' post-resection, there is a synchropresent evidence that interleukin (IL)-1 is the major inhibitor nous wave of hepatocyte mitosis with a histological mitotic of hepatocyte DNA synthesis present in CM-NPC-Reg. IL-1 index of the order of 30%. Hepatocytes may undergo more receptor antagonist abrogated the inhibition, as did antibodies than one round of replication, until the liver regains its forto rat IL-1a and-b; a combination of both antibodies was mer size-typically 7 to 10 days after resection in the rat required, implicating both IL-1a and IL-1b as active constitmodel-when the process terminates. The determinants of uents in CM-NPC-Reg. To investigate in vivo changes in IL-1 hepatocyte proliferation during liver regeneration are highly expression, we assessed expression of IL-1a messenger RNA complex, and different mechanisms operate during the initia-(mRNA) in whole rat liver following partial hepatectomy; tion of DNA synthesis and during the termination of the mRNA was down-regulated at 10 hours in the pre-replicative proliferative surge. Initiating processes within the liver inphase of liver regeneration and up-regulated at 24 hours and clude: 1) disruption of the extracellular matrix, which both 48 hours when proliferation is waning. Rat hepatocytes isorenders hepatocytes more sensitive to growth factors and lated from liver 24 hours after partial hepatectomy showed liberates matrix-sequestered hepatocyte mitogens such as heincreased sensitivity to the inhibitory action of IL-1. Exogepatocyte growth factor (HGF), heparin-binding epidermal nous IL-1b, administered parenterally to a group of rats at 0 growth factor (EGF), and acidic fibroblast growth factor; 3 2) and 12 hours after partial hepatectomy significantly reduced activation of enzymes that liberate active fragments of growth the incorporation of the thymidine analogue, bromodeoxyurifactors (e.g., plasminogen cleavage of HGF); 4 and 3) endine (BrdU), into hepatocytes at 18 hours. These data indicate hanced synthesis of autocrine (transforming growth factor that nonparenchymal cells isolated from regenerating rat liver [TGF] a) and paracrine (HGF) hepatocyte mitogens. 5,6 In elaborate IL-1, and support the hypothesis that IL-1 plays a addition, neural and systemic influences are recruited-noradrenaline, 7 insulin, and glucagon acting as co-mitogens, 8 and EGF from the submandibular gland, 9 have all been Abbreviations: HGF, hepatocyte growth factor; EGF, epidermal growth factor; TGF, shown to amplify or sustain the regenerative response. transforming growth factor; CM-NPC-Reg, conditioned medium from nonparenchymal In contrast, the mechanisms terminating the surge of DNA cells isolated from regenerating liver; CM-NPC-Con, conditioned medium from nonparenchymal cells from control liver; IL, interleukin; mRNA, messenger RNA; MTT, 3-synthesis have been less investigated until recently. The ter-[4,5-dimethylthiazol-2-yl]-2,5,-diphenyl tetrazolium bromide; PBS, phosphate-bufmination of proliferation and the restoration of normal liver fered saline; BrdU, bromodeoxyuridine; IL-1ra, interleukin-1 receptor antagonist. cell mass have been variously attributed to the temporary fall From the Department of Medicine, Royal Postgraduate Medical School, Hammerin concentration of a negative regulatory chalone normally</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Nonparenchymal cells from regenerating rat liver generate interleukin‐1α and‐1β: A mechanism of negative regulation of hepatocyte proliferation","attachmentId":81003657,"attachmentType":"pdf","work_url":"https://www.academia.edu/71809454/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1%CE%B1_and_1%CE%B2_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/71809454/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1%CE%B1_and_1%CE%B2_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="105178595" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105178595/Expression_of_hepatic_transcription_factors_during_liver_development_and_oval_cell_differentiation">Expression of hepatic transcription factors during liver development and oval cell differentiation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43593595" href="https://independent.academia.edu/SnorriThorgeirsson">Snorri Thorgeirsson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of cell biology, 1994</p><p class="ds-related-work--abstract ds2-5-body-sm">The oval cells are thought to be the progeny of a liver stem cell compartment and strong evidence now exists indicating that these cells can participate in liver regeneration by differentiating into different hepatic lineages. To better understand the regulation of this process we have studied the expression of liver-enriched transcriptional factors (HNF1 alpha and HNF1 beta, HNF3 alpha, HNF3 beta, and HNF3 gamma, HNF4, C/EBP, C/EBP beta, and DBP) in an experimental model of oval cell proliferation and differentiation and compared the expression of these factors to that observed during late stages of hepatic ontogenesis. The steady-state mRNA levels of four (HNF1 alpha, HNF3 alpha, HNF4, and C/EBP beta) &quot;liver-enriched&quot; transcriptional factors gradually decrease during the late period of embryonic liver development while three factors (HNF1 beta, HNF3 beta, and DBP) increase. In the normal adult rat liver the expression of all the transcription factors are restricted to th...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Expression of hepatic transcription factors during liver development and oval cell differentiation","attachmentId":104703211,"attachmentType":"pdf","work_url":"https://www.academia.edu/105178595/Expression_of_hepatic_transcription_factors_during_liver_development_and_oval_cell_differentiation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/105178595/Expression_of_hepatic_transcription_factors_during_liver_development_and_oval_cell_differentiation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="19656308" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19656308/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1_and_1_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation">Nonparenchymal cells from regenerating rat liver generate interleukin-1? and -1?: A mechanism of negative regulation of hepatocyte proliferation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40170601" href="https://independent.academia.edu/HumphreyHodgson">Humphrey Hodgson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">role suppressing hepatocyte proliferation and terminating the Following experimental partial hepatectomy of 70% in the surge of DNA synthesis induced after partial hepatectomy. rat, there is a semisynchronized surge of hepatocyte prolifera-(HEPATOLOGY 1997;26:49-58.) tion that ceases after 48 to 72 hours. Little is known about the determinants governing the termination of the proliferative phase, although transforming growth factor (TGF) b has been</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Nonparenchymal cells from regenerating rat liver generate interleukin-1? and -1?: A mechanism of negative regulation of hepatocyte proliferation","attachmentId":40762217,"attachmentType":"pdf","work_url":"https://www.academia.edu/19656308/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1_and_1_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19656308/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1_and_1_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="124192670" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124192670/The_Role_of_Id2_in_the_Regulation_of_Chromatin_Structure_and_Gene_Expression">The Role of Id2 in the Regulation of Chromatin Structure and Gene Expression</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="314175199" href="https://independent.academia.edu/rosaZARAGOZ%C3%81COLOM">rosa ZARAGOZÁ COLOM</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chromatin Remodelling, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Role of Id2 in the Regulation of Chromatin Structure and Gene Expression","attachmentId":118464378,"attachmentType":"pdf","work_url":"https://www.academia.edu/124192670/The_Role_of_Id2_in_the_Regulation_of_Chromatin_Structure_and_Gene_Expression","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/124192670/The_Role_of_Id2_in_the_Regulation_of_Chromatin_Structure_and_Gene_Expression"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":41368374,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":41368374,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_41368374" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Expression and localization of regenerating gene I in a rat liver regeneration model","attachmentId":113119770,"attachmentType":"pdf","work_url":"https://www.academia.edu/117200004/Expression_and_localization_of_regenerating_gene_I_in_a_rat_liver_regeneration_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/117200004/Expression_and_localization_of_regenerating_gene_I_in_a_rat_liver_regeneration_model"><span 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biophysical research communications, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Downregulation of IGF-1 receptor occurs after hepatic linage commitment during hepatocyte differentiation from human embryonic stem cells","attachmentId":89536261,"attachmentType":"pdf","work_url":"https://www.academia.edu/84554153/Downregulation_of_IGF_1_receptor_occurs_after_hepatic_linage_commitment_during_hepatocyte_differentiation_from_human_embryonic_stem_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/84554153/Downregulation_of_IGF_1_receptor_occurs_after_hepatic_linage_commitment_during_hepatocyte_differentiation_from_human_embryonic_stem_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="13787374" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13787374/Enhanced_liver_regeneration_following_changes_induced_by_hepatocyte_specific_genetic_ablation_of_integrin_linked_kinase">Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38540445" href="https://independent.academia.edu/JinLuo4">Jin Luo</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33431947" href="https://pitt.academia.edu/PallaviLimaye">Pallavi Limaye</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39273314" href="https://independent.academia.edu/PaulMonga">Paul Monga</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32893135" href="https://euc.academia.edu/VasilikiGkretsi">Vasiliki Gkretsi</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35876976" href="https://independent.academia.edu/UdayanApte">Udayan Apte</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="59191251" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/59191251/Rapid_induction_of_mRNAs_for_liver_regeneration_factor_and_insulin_like_growth_factor_binding_protein_1_in_primary_cultures_of_rat_hepatocytes_by_hepatocyte_growth_factor_and_epidermal_growth_factor">Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="172184512" href="https://independent.academia.edu/QiuyanChen2">Qiuyan Chen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor","attachmentId":73241720,"attachmentType":"pdf","work_url":"https://www.academia.edu/59191251/Rapid_induction_of_mRNAs_for_liver_regeneration_factor_and_insulin_like_growth_factor_binding_protein_1_in_primary_cultures_of_rat_hepatocytes_by_hepatocyte_growth_factor_and_epidermal_growth_factor","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39374724" href="https://independent.academia.edu/YusukeYamamoto1">Yusuke Yamamoto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Recapitulation ofin vivo gene expression during hepatic differentiation from murine embryonic stem cells","attachmentId":40468737,"attachmentType":"pdf","work_url":"https://www.academia.edu/19168352/Recapitulation_ofin_vivo_gene_expression_during_hepatic_differentiation_from_murine_embryonic_stem_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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</span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32857484" href="https://independent.academia.edu/HirayukiEnomoto">Hirayuki Enomoto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology Research, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatoma-derived growth factor is induced in liver regeneration","attachmentId":45009808,"attachmentType":"pdf","work_url":"https://www.academia.edu/13733176/Hepatoma_derived_growth_factor_is_induced_in_liver_regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13733176/Hepatoma_derived_growth_factor_is_induced_in_liver_regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="115885522" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/115885522/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1alpha_and_1beta_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation">Nonparenchymal cells from regenerating rat liver generate interleukin- 1alpha and -1beta: A mechanism of negative regulation of hepatocyte proliferation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39700117" href="https://independent.academia.edu/ClareSelden">Clare Selden</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Nonparenchymal cells from regenerating rat liver generate interleukin- 1alpha and -1beta: A mechanism of negative regulation of hepatocyte proliferation","attachmentId":112168829,"attachmentType":"pdf","work_url":"https://www.academia.edu/115885522/Nonparenchymal_cells_from_regenerating_rat_liver_generate_interleukin_1alpha_and_1beta_A_mechanism_of_negative_regulation_of_hepatocyte_proliferation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link 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class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38489406" href="https://thammasat.academia.edu/PakpoomKheolamai">Pakpoom Kheolamai</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Molecular Biology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Liver-enriched transcription factors are critical for the expression of hepatocyte marker genes in mES-derived hepatocyte-lineage cells","attachmentId":40083383,"attachmentType":"pdf","work_url":"https://www.academia.edu/18475679/Liver_enriched_transcription_factors_are_critical_for_the_expression_of_hepatocyte_marker_genes_in_mES_derived_hepatocyte_lineage_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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regenerating mouse liver accelerates hepatocyte entry into S phase</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38798235" href="https://independent.academia.edu/HonggangYe">Honggang Ye</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular and cellular biology, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase","attachmentId":40224761,"attachmentType":"pdf","work_url":"https://www.academia.edu/18732518/Premature_expression_of_the_winged_helix_transcription_factor_HFH_11B_in_regenerating_mouse_liver_accelerates_hepatocyte_entry_into_S_phase","alternativeTracking":true}"><span 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href="https://www.academia.edu/9281160/Expression_of_specific_hepatocyte_and_cholangiocyte_transcription_factors_in_human_liver_disease_and_embryonic_development">Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="21364743" href="https://independent.academia.edu/Alarc%C3%B3nG">Gabriela Alarcón</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Laboratory Investigation, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic 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class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13493052/Id1_is_a_critical_mediator_in_TGF_%CE%B2_induced_transdifferentiation_of_rat_hepatic_stellate_cells">Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32699700" href="https://deu.academia.edu/HarunSaid">Harun M ( U A Y A D ) Said</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Hepatology, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate 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