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data-nav="trigger" data-nav-search data-nav-target="nav-search" href="/search.aspx"><span class="a11y-sr-only">Search</span></a> <div class="nav__primary__dropdown" data-nav="target" id="nav-search"> <p data-module="label-float"> <label for="site-search"> <span class="nav-search__label--desktop">What are you searching for?</span> <span class="nav-search__label--mobile">Search</span> </label> <input type="search" id="site-search" value=""> <button class="fat-button"><span class="a11y-sr-only">Submit</span></button> </p> </div> </li> </ul> </nav> </header>    <main class="site-main" id="main-content" tabindex="-1"> <div id="panelMainContent"> <section class="layout-columns"> <div class="layout-columns__sidebar -padding--horizontal -padding--vertical -background--blue"> <div class="layout-columns__sidebar__content"> <h1 class="sidebar-heading"> <span class="sidebar-heading__subheading">Topic</span>Depression </h1> </div> </div> <div class="layout-columns__main -padding--vertical -padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=1057" itemprop="url"> Mindfulness-based Cognitive Therapy Shows Promise for Treating Depression in Chronically Ill Patients</a> </h3> <p itemprop="description"> <p>Mass General researchers were part of the first group to investigate whether mindfulness-based cognitive therapy might relieve depression in people with chronic pain.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/topic.aspx?id=1052" itemprop="relatedLink">Mindfulness</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2018-05-24" itemprop="datePublished">May 24, 2018</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=1158" itemprop="url"> Women with Major Depression During Pregnancy Have High Rates of Recurrence During Their Child's Formative Years</a> </h3> <p itemprop="description"> <p>Depression during pregnancy is highly likely to recur after delivery, Mass General researchers have determined. The finding implies that maternal depression is a major confounder when assessing the influence of prenatal antidepressant exposure on child neurodevelopment.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/topic.aspx?id=1032" itemprop="relatedLink">Female Mental Health</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2018-11-27" itemprop="datePublished">November 27, 2018</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/article-external.aspx?id=1039" itemprop="url"> Effective Ketamine Dosages for Treatment-resistant Depression Identified</a> </h3> <p itemprop="description"> <p>Ketamine has long been used as a general anesthetic, but more recent research has found it to be effective in rapidly relieving depression symptoms when given at low, subanesthetic doses. New research identifies two optimal dosages.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/topic.aspx?id=1041" itemprop="relatedLink">Ketamine Treatment</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2018-11-07" itemprop="datePublished">November 7, 2018</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=2646" itemprop="url"> Propensity Score Weighting Accounts Well for Placebo Response in Two Trials of Medical Therapy for MDD</a> </h3> <p itemprop="description"> <p>Maurizio Fava, MD, and colleagues previously developed an AI approach to account for the propensity to respond to placebo in randomized, controlled trials of drugs for major depressive disorder (MDD), and they show the method more accurately interprets the results of trials complicated by the placebo response.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-09-10" itemprop="datePublished">September 10, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/q-a.aspx?id=1027" itemprop="url"> Chief of Psychiatry, Maurizio Fava, MD, Discusses U.S. News & World Report ranking Mass General #1 for Psychiatry in 2024-25</a> </h3> <p itemprop="description"> <p><span>The Massachusetts General Hospital Department of Psychiatry has been recognized for its exceptional commitment to advancing mental healthcare. Mass General was ranked #1 Psychiatry in the nation for Psychiatry in 2024-25 by U.S. News and World Report.</span></p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/topic.aspx?id=1041" itemprop="relatedLink">Ketamine Treatment</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -qa">Q & A</span> <time class="date" datetime="2024-07-16" itemprop="datePublished">July 16, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=2629" itemprop="url"> Children of Parents With ADHD Are at Substantial Risk of Developing ADHD and Associated Impairments</a> </h3> <p itemprop="description"> <p><span>Joseph Biederman, MD, Mai Uchida, MD, and colleagues have demonstrated that children of parents who have ADHD are at significant risk of developing full or subsyndromal forms of ADHD themselves, as well as ADHD-associated psychiatric, cognitive, social, and educational impairments.</span></p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1044" itemprop="relatedLink">ADHD</a>, <a href="/neuro/topic.aspx?id=1031" itemprop="relatedLink">Depression</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-06-17" itemprop="datePublished">June 17, 2024</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=depression&maxResults=15">View All Depression Updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Depression Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Cristina Cusin, MD" itemprop="image" srcset="/assets/images/contributors/cristina_cusin_advances.png, /assets/images/contributors/cristina_cusin_advances_2x.png 2x" src="/assets/images/contributors/cristina_cusin_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1221" itemprop="url">Cristina Cusin, MD</a> </h3> <p itemprop="jobTitle"> Assistant Professor in Psychiatry, Staff Psychiatrist, Depression Clinical and Research Program</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/article.aspx?id=1088">Q&A with Dr. Cristina Cusin: What to Know About Esketamine and Ketamine Treatment</a> </p> </div> <p class="profile-card__image"> <img alt="Cristina Cusin, MD" itemprop="image" srcset="/assets/images/contributors/cristina_cusin_advances.png, /assets/images/contributors/cristina_cusin_advances_2x.png 2x" src="/assets/images/contributors/cristina_cusin_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/David_Mischoulon_advances.png, /assets/images/contributors/David_Mischoulon_advances_2x.png 2x" src="/assets/images/contributors/David_Mischoulon_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1127" itemprop="url">David Mischoulon, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director, Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Joyce R. Tedlow Professor of Psychiatry, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2593">Heated Yoga Linked to Reduction of Moderate to Severe Depressive Symptoms in Randomized Controlled Trial</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/David_Mischoulon_advances.png, /assets/images/contributors/David_Mischoulon_advances_2x.png 2x" src="/assets/images/contributors/David_Mischoulon_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Fava_advances.png, /assets/images/contributors/Fava_advances_2x.png 2x" src="/assets/images/contributors/Fava_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1128" itemprop="url">Maurizio Fava, MD</a> </h3> <p itemprop="jobTitle"> Psychiatrist-In-Chief; Director, Division of Clinical Research of the MGH Research Institute, Executive Director, Clinical Trials Network and Institute (CTNI), Massachusetts General Hospital, Associate Dean for Clinical & Translational Research, Slater Family Professor of Psychiatry, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2646">Propensity Score Weighting Accounts Well for Placebo Response in Two Trials of Medical Therapy for MDD</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Fava_advances.png, /assets/images/contributors/Fava_advances_2x.png 2x" src="/assets/images/contributors/Fava_advances.png"> </p> </li> </ul> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block 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