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class="container"> <div class="grid"> <div class="cell-md-9"> <p class="breadcrumbs"><a href="/">Home</a> / Education / Disease Spotlight / <span class="blue">Neurology</span></p> <h1>Bring neurology discoveries to light with the SomaScan® Assay</h1> <p>Detect low-abundance proteins in complex sample types, including cerebrospinal fluid and blood.</p> </div> </div> </div> </div><div class="wrap white " id="wrap_0" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><h2 style="text-align: center">Unlocking advances in <em class="blue">neurological research</em></h2> <p>Nearly 100 million people in the United States alone suffer from one of more than 1,000 different neurological diseases.<sup>1</sup> These diseases can derive from various sources, such as faulty genes, problems with development of the nervous system, degeneration of the nervous system, dysfunctional proteins, and signaling pathways.<sup>2-4</sup></p> <p>In neurological research and clinical settings, the use of biomarkers is crucial for a deeper understanding of the mechanisms behind these diseases and for enabling early detection. Traditionally, neurology has relied on cognitive assessments, imaging techniques, and postmortem brain tissue analysis to study disease. In recent years, proteomics, or protein profiling, has emerged as a powerful tool in neurological research. Proteomics can measure complex body fluids like cerebrospinal fluid (CSF), providing a comprehensive approach that allows researchers to accurately identify potential biomarkers. This improves knowledge of disease mechanisms and enables earlier detection and the development of targeted treatments.</p> <h3 style="text-align: center">The power of proteomics with the SomaScan Assay</h3> <p>The <a href="https://somalogic.com/somascan-platform/">SomaScan Platform</a> harnesses the power of proteomics for targeted research, facilitating the discovery of potential biomarkers and utilization as a research tool in clinical trials.</p> <p>By leveraging high-content profiling, the platform can be used to further the study of a range of neurologic diseases, including Alzheimer’s disease, Parkinson’s disease, spinal cord disorders, as well as cancer.<sup>5-9</sup> In addition, this sensitive proteomics approach can be used to identify and track blood- and cerebrospinal fluid-based biomarkers, which can be used in research related to disease and disease progression<sup>5,10</sup>, ultimately translating to faster drug development.</p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><hr /> </div> </div><div class="text-block cell-md-10 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="mb-60"><h2 class="a-center">CSF offers insight into neurologic disease pathology through comprehensive protein measurement</h2> </div> </div><div class="text-block cell-md-5 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-9095" src="https://somalogic.com/wp-content/uploads/2024/09/CSF_PortraitImage2.webp" alt="Gloved hand in a lab, holding sample of cerebrospinal fluid" width="387" height="600" srcset="https://somalogic.com/wp-content/uploads/2024/09/CSF_PortraitImage2.webp 387w, https://somalogic.com/wp-content/uploads/2024/09/CSF_PortraitImage2-194x300.webp 194w, https://somalogic.com/wp-content/uploads/2024/09/CSF_PortraitImage2-161x250.webp 161w" sizes="auto, (max-width: 387px) 100vw, 387px" /></p> </div> </div><div class="text-block cell-md-7 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><p>Cerebrospinal fluid (CSF) is a critical fluid for neurological research due to its association with the central nervous system. The <a href="/somascan-11k-assay/">SomaScan 11K Assay</a> now supports CSF samples, offering even greater precision in neurological research and biomarker discovery. By incorporating CSF samples, the SomaScan 11K Assay enables researchers to gain deeper insights into disease mechanisms and protein biomarkers specific to neurological disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and other neurodegenerative conditions. This expanded capability accelerates advancements in neurobiology and translational research.</p> <h3><span style="color: black;font-weight: bold">CASE STUDY</span> Revealing New Insights in Parkinson’s Disease Using CSF Samples and the SomaScan Assay</h3> <p>This case study by Phillips et al. presents the largest SOMAmer® reagent-based proteomics analysis of CSF to date, identifying 25 proteins linked to Parkinson’s disease. The study highlights the utility of the SomaScan Assay in analyzing CSF to uncover novel protein associations, contributing to a deeper understanding of neurological disorders. Learn how CSF proteomics can enhance biomarker discovery and therapeutic research.<br /> <a class="btn blue" style="margin-top: 30px" href="https://somalogic.com/somascan-assay-case-study-advancing-biomarker-discovery-in-neurological-diseases-through-csf-proteomics/">View full case study</a></p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><hr /> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>Biomarker discovery and identification<br /> with the <em class="blue">SomaScan 11K Assay</em></h2> <p>Over 3,500 protein targets associated with neurology can be measured using the SomaScan 11K Assay. This figure depicts a protein-protein interaction network of Alzheimer’s disease associated protein targets (i.e. Apo-E, Tau, BDNF) using the pathway analysis tool STRING. A comprehensive list of protein targets included in the SomaScan 11K Assay is accessible via the <a href="https://somalogic.com/somascan-menu/">SomaScan Menu Tool</a>.</p> </div> </div><div class="text-block cell-md-10 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="aligncenter wp-image-8289 size-large" src="https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-1024x907.png" alt="String chart" width="1024" height="907" srcset="https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-1024x907.png 1024w, https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-300x266.png 300w, https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-768x680.png 768w, https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-1536x1360.png 1536w, https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-2048x1813.png 2048w, https://somalogic.com/wp-content/uploads/2024/07/string_hires_image-282x250.png 282w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mt-60"><h2>Look deeper with the <em class="blue">SomaScan Platform</em></h2> </div> </div><div class="cards-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class=" cards " ><div class="card transparent owl-block" title="Speedometer-like graphic"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2022/06/High-Throughput_Hex.png" alt="Speedometer-like graphic" /></p> <h3>Multiplex, high-throughput proteomics</h3> <div class="content"><p class="a-center">Profile <a href="https://somalogic.com/somascan-assay-services/">11,000 protein measurements</a> per sample and conduct high-throughput analysis of >1,000 samples simultaneously.<sup>5</sup></p> </div> </div> </div><div class="card transparent owl-block" title="Magnifying glass"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2022/06/Sensitive_Hex.png" alt="Magnifying glass" /></p> <h3>Sensitive detection</h3> <div class="content"><p class="a-center">Detect and quantify a <a href="https://somalogic.com/dynamic-range/">wide dynamic range</a> of proteins (from fmol – µmol) in complex sample types, including cerebrospinal fluid and blood.<sup>5,10</sup></p> </div> </div> </div><div class="card transparent owl-block" title="Small hexagons together"> <div> <p><img src="https://somalogic.com/wp-content/uploads/2022/06/Reproducible_Hex.png" alt="Small hexagons together" /></p> <h3>Reproducible</h3> <div class="content"><p class="a-center">Obtain consistent and <a href="https://somalogic.com/coefficients-of-variation/">reproducible</a> inter- and intra-assay results for data analysis and comparison.<sup>5</sup></p> </div> </div> </div></div> </div></div> </div> </div><div class="wrap grey " id="wrap_1" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="aligncenter wp-image-8051 size-medium" src="https://somalogic.com/wp-content/uploads/2024/05/ErikJohnson-300x300.jpg" alt="Erik Johnson, MD, PhD, Assistant Professor, Department of Neurology Emory University" width="300" height="300" srcset="https://somalogic.com/wp-content/uploads/2024/05/ErikJohnson-300x300.jpg 300w, https://somalogic.com/wp-content/uploads/2024/05/ErikJohnson-150x150.jpg 150w, https://somalogic.com/wp-content/uploads/2024/05/ErikJohnson-250x250.jpg 250w, https://somalogic.com/wp-content/uploads/2024/05/ErikJohnson.jpg 400w" sizes="auto, (max-width: 300px) 100vw, 300px" /></p> </div> </div><div class="text-block cell-md-8 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><h3 style="color: black">Using proteomics to advance understanding of alzheimer’s disease</h3> <p>Limited understanding due to its complex pathophysiology and lack of definitive biomarkers currently constrains the diagnosis and treatment of Alzheimer’s disease (AD). But new research is uncovering dynamic brain changes during Alzheimer’s progression, offering potential therapeutic targets. This webinar explores how proteomics and systems biology can be integrated to elucidate AD pathology.</p> <p><a class="btn blue" href="https://somalogic.com/webinar/using-proteomics-to-advance-understanding-of-alzheimers-disease/">View webinar</a></p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center desktop"><hr style="height: 0px" /> </div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-7815" src="https://somalogic.com/wp-content/uploads/2024/04/KeenanWalkerPaper_Preview-1.jpg" alt="Preview of Application Focus paper from Dr Keenan Walker - SomaLogic" width="300" height="300" srcset="https://somalogic.com/wp-content/uploads/2024/04/KeenanWalkerPaper_Preview-1.jpg 300w, https://somalogic.com/wp-content/uploads/2024/04/KeenanWalkerPaper_Preview-1-150x150.jpg 150w, https://somalogic.com/wp-content/uploads/2024/04/KeenanWalkerPaper_Preview-1-250x250.jpg 250w" sizes="auto, (max-width: 300px) 100vw, 300px" /></p> </div> </div><div class="text-block cell-md-8 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><h3 style="color: black">Application Focus: Exploring Brain Diseases Through Plasma Proteomics</h3> <p>Keenan Walker, PhD and Chief, Multimodal Imaging of Neurodegenerative Disease (MIND), National Institute on Aging (NIH) summarizes information that explores the relationship between systemic proteins and Alzheimer’s disease in this paper. This paper is based on his presentation from the webinar titled “Using plasma proteomics to understand Alzheimer’s and other brain diseases”.</p> <p><a class="btn blue" href="https://share.hsforms.com/1liy7id4PQEaxaLlqj15FCA3zbc6" target="_blank" rel="noopener">Download application focus</a></p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center desktop"><hr style="height: 0px" /> </div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-7475" src="https://somalogic.com/wp-content/uploads/2024/03/Wyss-Coray-square.jpg" alt="Tony Wyss-Coray, PhD" width="300" height="300" srcset="https://somalogic.com/wp-content/uploads/2024/03/Wyss-Coray-square.jpg 300w, https://somalogic.com/wp-content/uploads/2024/03/Wyss-Coray-square-150x150.jpg 150w, https://somalogic.com/wp-content/uploads/2024/03/Wyss-Coray-square-250x250.jpg 250w" sizes="auto, (max-width: 300px) 100vw, 300px" /></p> </div> </div><div class="text-block cell-md-8 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><h3 style="color: black">Young blood for old brains and the quest to slow brain aging</h3> <p>Tony Wyss-Coray, PhD, D.H. Chen Distinguished Professor of Neurology and Neurological Sciences and Director of the Phil and Penny Knight Initiative for Brain Resilience at Stanford University, presents data on his team’s findings that blood-borne factors from young humans and mice are sufficient to counteract aspects of brain aging and improve cognitive function in old mice, while blood plasma from old organisms is detrimental to young mice and impairs their cognition.</p> <p><a class="btn blue" href="https://somalogic.com/webinar/young-blood-for-old-brains-and-the-quest-to-slow-brain-aging/">Watch on-demand webinar</a></p> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center desktop"><hr style="height: 0px" /> </div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="alignnone size-full wp-image-6661" src="https://somalogic.com/wp-content/uploads/2023/12/brainNeurons-square.jpg" alt="Abstract image of brain neruons" width="300" height="300" srcset="https://somalogic.com/wp-content/uploads/2023/12/brainNeurons-square.jpg 300w, https://somalogic.com/wp-content/uploads/2023/12/brainNeurons-square-150x150.jpg 150w, https://somalogic.com/wp-content/uploads/2023/12/brainNeurons-square-250x250.jpg 250w" sizes="auto, (max-width: 300px) 100vw, 300px" /></p> </div> </div><div class="text-block cell-md-8 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40"><h3 style="color: black">Proteomics for precision neuroscience: The power of protein analysis</h3> <p>Christopher Whelan, MSc, PhD, Carlos Cruchaga, PhD, and Keenan Walker, PhD, discuss how academic, industry, and government researchers are directly measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases.</p> <p><a class="btn blue" href="https://somalogic.com/webinar/proteomics-for-precision-neuroscience-the-power-of-protein-analysis/">Watch on-demand webinar</a></p> </div> </div></div> </div> </div><div class="wrap white " id="wrap_2" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2>Advanced <em class="blue">proteomics offerings</em> in neurology</h2> <p>The <a href="https://somalogic.com/somascan-platform/">SomaScan Platform</a> is available in multiple formats, each providing unique data outputs to fast-track your neurology research.</p> </div> </div><div class="cards-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0"> <div class=" cards " ><div class="card white owl-block" title=""> <div> <h3>SomaScan Assay</h3> <div class="content"><p class="a-center">With the ability to profile thousands of proteins simultaneously, the SomaScan Assay is well-suited to measuring low- and high-abundant proteins in a small amount of blood or cerebrospinal fluid.<sup>5,10</sup></p> </div> <p class="a-center"><a href="https://somalogic.com/somascan-assay-services/" class="btn blue on-white" target="">Learn more</a></p> </div> </div><div class="card white owl-block" title=""> <div> <h3>SomaScan Panels</h3> <div class="content"><p class="a-center">These custom panels can be individualized from our menu of 11,000 protein analytes. The assay is also offered as a neuroscience panel containing 1,316 preset analytes most relevant to neurology-focused proteomics. This panel focuses on significant neurologic disease associations including Alzheimer’s disease, Parkinson’s disease, spinal cord disorders, cancer, ischemia, seizures, addiction, pain, and others.<sup>5</sup></p> </div> <p class="a-center"><a href="/somascan-panels/" class="btn blue on-white" target="">Learn more</a></p> </div> </div><div class="card white owl-block" title=""> <div> <h3>SomaSignal<sup>®</sup> Tests</h3> <div class="content"><p class="a-center">Monitor clinical metrics, including those associated with dementia and other critical parameters, such as cardiovascular fitness and glucose tolerance.<sup>5,11</sup></p> </div> <p class="a-center"><a href="https://somalogic.com/somascan-assay-services/" class="btn blue on-white" target="">Learn more</a></p> </div> </div></div> </div></div> </div> </div><div class="wrap grey " id="wrap_3" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><h2 class="mb-60">Curated neurology research publications</h2> <div class="wpdt-c wdt-skin-light"> <input type="hidden" id="table_2_desc" 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<th data-class="expand" class=" wdtheader sort " style=""> Title</th> <th class=" wdtheader sort " style=""> Author</th> <th data-hide="phone,tablet" class="phone,tablet wdtheader sort " style=""> Year</th> <th data-hide="phone,tablet" class="phone,tablet wdtheader sort " style=""> Journal</th> <th class=" wdtheader sort " style=""> Link</th> </tr> </thead>   <tbody>  <div data-id="35" class="wdt-timeline-item wdt-timeline-table_2" style=""> <div class="wdt-table-loader"> <div class="wdt-table-loader-row wdt-table-loader-header"> <div class="wdt-table-loader-header-cell wdt-animated-background"></div> <div class="wdt-table-loader-header-cell wdt-animated-background"></div> <div class="wdt-table-loader-header-cell wdt-animated-background"></div> </div> <div class="wdt-table-loader-row"> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> <div class="wdt-table-loader-cell wdt-animated-background"></div> 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for differentiating bipolar disorder from major depressive disorder</td> <td style="">Idemoto K, et al.</td> <td style="">2021</td> <td style="">J Psychiatr Res</td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/33360224/' rel='' target='_blank'><button class='SL-btn'>View now</button></a></td> </tr> <tr id="table_35_row_2" data-row-index="2"> <td style="">Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology</td> <td style="">Morani F, et al.</td> <td style="">2020</td> <td style="">Front Neurol</td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/33584503/' rel='' target='_blank'><button class='SL-btn'>View now</button></a></td> </tr> <tr id="table_35_row_3" data-row-index="3"> <td style="">Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function</td> <td style="">Adams J, et al.</td> <td style="">2023</td> <td style="">Sci Advances</td> <td style=""><a href='https://www.science.org/doi/10.1126/sciadv.adf8764' rel='' target='_blank'><button class='SL-btn'>View now</button></a></td> </tr> <tr id="table_35_row_4" data-row-index="4"> <td style="">Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.</td> <td style="">Rutledge, J. et al.</td> <td style="">2024</td> <td style="">Acta Neuropathol.</td> <td style=""><a href='https://pubmed.ncbi.nlm.nih.gov/38467937/' rel='' target='_blank'><button class='SL-btn'>View now</button></a></td> </tr> <tr id="table_35_row_5" data-row-index="5"> <td style="">Head-to-head comparison of aptamer- and antibody-based proteomic platforms in human cerebrospinal fluid samples from a real-world memory clinic cohort</td> <td style="">Puerta R, et al.</td> <td style="">2024</td> <td style="">medRxiv Preprint</td> <td style=""><a href='https://www.medrxiv.org/content/10.1101/2024.07.18.24310563v1' rel='' target='_blank'><button class='SL-btn'>View 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Ann Neurol. 2017;81(4):479-484. doi:10.1002/ana.24897. <strong>2.</strong> Moujalled D, Strasser A, Liddell JR. Molecular mechanisms of cell death in neurological diseases. Cell Death Differ. 2021;28(7):2029-2044. doi:10.1038/s41418-021-00814-y. <strong>3.</strong> McKinnon PJ. DNA repair deficiency and neurological disease. Nat Rev Neurosci. 2009;10(2):100-112. doi:10.1038/nrn2559. <strong>4.</strong> Sweeney P, Park H, Baumann M, et al. Protein misfolding in neurodegenerative diseases: implications and strategies. Transl Neurodegener. 2017;6:6. doi:10.1186/s40035-017-0077-5. <strong>5.</strong> Data on file. SomaLogic Operating Co., Inc. <strong>6.</strong> Ward M, Schofield EL. Biomarkers for brain disorders. Therapy. 2010;7(4):321-336. <strong>7.</strong> Shi L, Winchester LM, Westwood S, et al. Replication study of plasma proteins relating to Alzheimer’s pathology. Alzheimers Dement. 2021;17(9):1452-1464. doi:10.1002/alz.12322. <strong>8.</strong> Yang C, Farias FHG, Ibanez L, et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat Neurosci. 2021;24(9):1302-1312. doi:10.1038/s41593-021-00886-6. <strong>9.</strong> Candia J, Cheung F, Kotliarov Y, et al. Assessment of variability in the SOMAscan Assay. Sci Rep. 2017;7(1):14248. doi:10.1038/s41598-017-14755-5. <strong>10.</strong> Masvekar R, Wu T, Kosa P, Barbour C, Fossati V, Bielekova B. Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity. Mult Scler Relat Disord. 2019;28:34-43. doi:10.1016/j.msard.2018.11.032. <strong>11.</strong> Walker KA, Chen J, Zhang J, et al. Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk. 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