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-padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/article.aspx?id=1182" itemprop="url"> Biomarkers of T Cell Exhaustion in Checkpoint Inhibitor Therapy</a> </h3> <p itemprop="description"> <p></p> <p></p> <p>Could altering the balance between two CD8+ T cell states enhance immunotherapies? Research from the Massachusetts General Hospital Cancer Center seeks to find the answer.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1062" itemprop="relatedLink">Immuno-Oncology</a>, <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2020-05-28" itemprop="datePublished">May 28, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=1389" itemprop="url"> New Approach to CAR T-Cell Therapy for Glioblastoma Aims to Circumvent Antigen Escape</a> </h3> <p itemprop="description"> <p>A dual-antigen approach to immunotherapy for glioblastoma, pioneered at Massachusetts General Hospital, addresses antigenic heterogeneity and may have applications for treating other types of solid tumors.</p></p> <p class="content-tease__related"> <a href="/oncology/topic.aspx?id=1100" itemprop="relatedLink">CAR T-cell Therapy</a>, <a href="/research-and-innovation/topic.aspx?id=1114" itemprop="relatedLink">Gene and Cell Therapy</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-10-24" itemprop="datePublished">October 24, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/video.aspx?id=1099" itemprop="url"> Using Immunotherapy to Treat Brain Tumors</a> </h3> <p itemprop="description"> <p>In this video, William Curry, MD, discusses advancements in immunotherapy to target brain tumors. In clinical trials, he has seen the safety and strong immune activity of vaccinating patients with their own tumor cells, which has made him optimistic about the future of treatment for patients with brain tumors.</p></p> <p class="content-tease__related"> <a href="/neuro/topic.aspx?id=1022" itemprop="relatedLink">Brain Tumor</a>, <a href="/oncology/topic.aspx?id=1081" itemprop="relatedLink">Immunotherapy</a>, <a href="/oncology/topic.aspx?id=1061" itemprop="relatedLink">Neuro-Oncology</a>, <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/neuro/topic.aspx?id=1019" itemprop="relatedLink">Neurosurgery</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -video">Video</span> <time class="date" datetime="2019-08-27" itemprop="datePublished">August 27, 2019</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=immuno-oncology&maxResults=15">View All Immuno-Oncology Updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Mass General Cancer Center Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Bob_Carter_20120_advances.png, /assets/images/contributors/Bob_Carter_20120_advances_2x.png 2x" src="/assets/images/contributors/Bob_Carter_20120_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1106" itemprop="url">Bob S. Carter, MD, PhD</a> </h3> <p itemprop="jobTitle"> Chief, Neurosurgery Service</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2532">Co-transplantation of Regulatory T Cells Improves Cell Replacement Therapy for Parkinson's Disease</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Bob_Carter_20120_advances.png, /assets/images/contributors/Bob_Carter_20120_advances_2x.png 2x" src="/assets/images/contributors/Bob_Carter_20120_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Chin-Lee Wu" itemprop="image" srcset="/assets/images/contributors/chin-lee_wu_advances.png, /assets/images/contributors/chin-lee_wu_advances_2x.png 2x" src="/assets/images/contributors/chin-lee_wu_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1188" itemprop="url">Chin-Lee Wu, MD, PhD</a> </h3> <p itemprop="jobTitle"> Director, Genitourinary Pathology Service, Massachusetts General Hospital and Mass General Cancer Center, Professor of Pathology, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/urology/journal.aspx?id=2632">Multiparametric MRI Is Often False-Negative for Clinically Significant Prostate Cancer</a> </p> </div> <p class="profile-card__image"> <img alt="Chin-Lee Wu" itemprop="image" srcset="/assets/images/contributors/chin-lee_wu_advances.png, /assets/images/contributors/chin-lee_wu_advances_2x.png 2x" src="/assets/images/contributors/chin-lee_wu_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1516" itemprop="url">Kerry L. Reynolds, MD</a> </h3> <p itemprop="jobTitle"> Clinical Director, Inpatient Oncology Units, Director, Severe Immunotherapy Complications Program</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=1452">Researchers Chart the Course of Severe Checkpoint Inhibitor-related Colitis</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. Dougan" itemprop="image" srcset="/assets/images/contributors/michael_dougan_advances.png, /assets/images/contributors/michael_dougan_advances_2x.png 2x" src="/assets/images/contributors/michael_dougan_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1517" itemprop="url">Michael L. Dougan, MD, PhD</a> </h3> <p itemprop="jobTitle"> Physician, Division of Gastroenterology, Massachusetts General Hospital, Director, GI Center for Cancer Complications, Mass General Cancer Center, Preclinical Education Group Leader, Associate Professor of Medicine, Harvard Medical School </p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2637">Case Series: Tofacitinib Is Effective in Treating Refractory Immune Checkpoint Inhibitor Hepatitis</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. Dougan" itemprop="image" srcset="/assets/images/contributors/michael_dougan_advances.png, /assets/images/contributors/michael_dougan_advances_2x.png 2x" src="/assets/images/contributors/michael_dougan_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Dr. Hacohen" itemprop="image" srcset="/assets/images/contributors/nir_hacohen_advances.png, /assets/images/contributors/nir_hacohen_advances_2x.png 2x" src="/assets/images/contributors/nir_hacohen_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1406" itemprop="url">Nir Hacohen, PhD</a> </h3> <p itemprop="jobTitle"> <ital>Director, MGH Center for Cancer Immunology</ital><br/>Center for Cancer Research , Professor of Medicine, Harvard Medical School, Senior Member, Broad Institute</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/oncology/journal.aspx?id=2373">Considering Both Tumor and Immune Features May Improve Prediction of Melanoma Outcomes After Checkpoint Inhibition</a> </p> </div> <p class="profile-card__image"> <img alt="Dr. Hacohen" itemprop="image" srcset="/assets/images/contributors/nir_hacohen_advances.png, /assets/images/contributors/nir_hacohen_advances_2x.png 2x" src="/assets/images/contributors/nir_hacohen_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Tomas_Neilan_19347_advances.png, /assets/images/contributors/Tomas_Neilan_19347_advances_2x.png 2x" src="/assets/images/contributors/Tomas_Neilan_19347_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1041" itemprop="url">Tomas G. Neilan, MD, MPH</a> </h3> <p itemprop="jobTitle"> Director, Cardio-Oncology Program, Massachusetts General Hospital, Co-Director, Cardiac MR PET CT Program</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/cardiovascular/journal.aspx?id=1968">T1 Value on Cardiac MRI Diagnoses Myocarditis Associated with Checkpoint Inhibitors</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/Tomas_Neilan_19347_advances.png, /assets/images/contributors/Tomas_Neilan_19347_advances_2x.png 2x" src="/assets/images/contributors/Tomas_Neilan_19347_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1118" itemprop="url">William T. Curry, MD</a> </h3> <p itemprop="jobTitle"> Co-Director, Mass General Neuroscience , Director of Neurosurgical Oncology, Massachusetts General Hospital, Adeline Rose Wydotis Professor of Neurosurgery, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/neuro/journal.aspx?id=2588">Review: The Role of Antibody-Based Therapies in Neuro-Oncology</a> </p> </div> <p class="profile-card__image"> <img alt="William Curry, MD" itemprop="image" srcset="/assets/images/contributors/William_Curry_17181_advances.png, /assets/images/contributors/William_Curry_17181_advances_2x.png 2x" src="/assets/images/contributors/William_Curry_17181_advances.png"> </p> </li> </ul> <p class="fat-link__wrapper u-text-centered"> <button class="fat-link -plus -large" data-module="view-cards" data-target="#profile-cards" data-show="4">Mass General Cancer Center Contributors</button> </p> </div> </section> <div class="content-container -width--xwide -centered 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