Enzyme Products and Resources

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These include enzymes involved in post-translational modifications such as ubiquitination, glycosylation, or phosphorylation, enzymes with immunotherapeutic potential, and enzymes used for bioprocessing applications.</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-enzyme-hero-img.png" alt="3D image of an Enzyme" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/reagents">Bio-Techne Reagents</a> </li> <li> Enzymes </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="#ubiquitin">Ubiquitin-Related Enzymes</a> | <a href="#glycobiology">Glycobiology-Related Enzymes</a> | <a href="#immunotherapy">Immunotherapy-Related Enzymes</a> | <a href="#kinases">Kinases & Phosphatases</a> | <a href="#bioprocessing">Bioprocessing Enzymes</a> | <a href="#bulk">Bulk Enzymes</a> | <a href="#resources">Resources</a> | <a href="#background">Background Information</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="ubiquitin"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Ubiquitin-related Enzymes</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>• The highest purity <a href="/search?keywords=e1%20Activating%20Enzymes&brand=rnd&category_attr=Proteins%20and%20Enzymes">E1 activating enzymes</a> for Ubiquitin, SUMO, NEDD8, ISG15, and other Ubiquitin-like proteins</p> <p>• The widest selection of <a href="/search?keywords=e2%20Conjugating%20Enzymes&brand=rnd&category_attr=Proteins%20and%20Enzymes">E2 conjugating enzymes</a>, including E2s for HECT-, RBR- and RING-type E3s, monoubiquitylating E2s, K11-, K48-, and K63-specific chain building E2s, and the SUMO and Neddylation E2s</p> <p>• The largest collection of highly active <a href="/search?keywords=e3%20ligase&brand=rnd&category_attr=Proteins%20and%20Enzymes&view=condensed">E3 ligases</a>, including HECT-, RBR-, SCF-, and other RING classes</p> <p>• The most active, full-length recombinant <a href="/search?keywords=Deubiquitinating%20enzymes&view=condensed&brand=rnd&category_attr=Proteins%20and%20Enzymes">deubiquitinase enzymes</a> on the market</p> <p>• <a href="/search?keywords=proteasome&view=condensed&brand=rnd&category_attr=Proteins%20and%20Enzymes">Proteasome complexes</a> including the 19S, 20S, and 26S proteasomes, the 20S immunoproteasome and the PA28 a, b, or g regulatory complexes</p> <p>• <a href="/services/custom-protein-services">Custom services</a> for polyubiquitin characterization, DUB profiling, and protein purification are available to meet every researcher’s need</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/reagents/proteins/ubiquitin-proteasome-system" class="btn btn-primary" type="link"> Explore Ubiquitin-related Enzymes </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/ubiquitin-related-enzymes-450x400.jpg" alt="Ubiquitin-Related Enzymes" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="glycobiology"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/glycobiology-related-enzymes-450x400.jpg" alt="Glycobiology-Related Enzymes" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h2>Glycobiology-related Enzymes</h2></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>• A large selection of <a href="/search?keywords=fucosyltransferase&category_attr=Proteins%20and%20Enzymes">fucosyltransferases</a> with clickable substrate <a href="/p/small-molecules-peptides/gdp-azido-fucose_es101">GDP-Azido-Fucose</a> for investigating core-, terminal-, and protein O-fucosylation modifications</p> <p>• <a href="/search?keywords=sialyltransferase&view=condensed&category_attr=Proteins%20and%20Enzymes">Sialyltransferases</a> with clickable substrate <a href="/p/small-molecules-peptides/cmp-azido-sialic-acid_es102">CMP-Azido-Sialic Acid</a> and <a href="/p/small-molecules-peptides/cmp-c9-biotin-sialic-acid_es201">CMP-C9-Biotin-Sialic Acid</a> for exploring alpha2-3, alpha2-6, and alpha2-8 sialylation of different glycoproteins or glycolipids</p> <p>• A wide selection of highly active <a href="/search?keywords=n-acetylglucosaminyltransferase&view=condensed&category_attr=Proteins%20and%20Enzymes">N-acetylglucosaminyltransferases</a> with clickable substrates <a href="/p/small-molecules-peptides/udp-azido-glcnac_es104">UDP-Azido-GlcNAc</a> and <a href="/search?keywords=n-acetylgalactosaminyltransferase&view=condensed&category_attr=Proteins%20and%20Enzymes">N-acetylgalactosaminyltransferases</a> with clickable substrate <a href="/p/small-molecules-peptides/udp-azido-galnac_es103">UDP-Azido-GalNAc</a></p> <p>• Highly active <a href="/search?keywords=heparinase&view=condensed&category_attr=Proteins%20and%20Enzymes">heparinases</a>, <a href="/t/heparanase-hpse/proteins-enzymes">heparanases</a>, <a href="/search?keywords=chondroitinase&view=condensed&category_attr=Proteins%20and%20Enzymes">chondroitinases</a>, and <a href="/search?keywords=hyaluronidase&view=condensed&category_attr=Proteins%20and%20Enzymes">hyaluronidases</a> for studying various glycosaminoglycans</p> <p>• The largest collection of human lysosomal <a href="/search?keywords=glycosidase&view=condensed&category_attr=Proteins%20and%20Enzymes">glycosidases</a> that can be used as enzymatic tools as well as drug targets</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/search?keywords=glycobiologyenzymes&category_attr=Proteins%20and%20Enzymes" class="btn btn-primary" type="link"> Search Glycobiology-related Enzymes </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="immunotherapy"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Immunotherapy-related Enzymes</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>• A large selection of enzymes involved in amino acid metabolism that are potential immunotherapeutic targets, including <a href="/t/indoleamine-2-3-dioxygenase-ido?category_attr=Proteins%20and%20Enzymes">IDO</a>, <a href="/t/tdo2?category_attr=Proteins%20and%20Enzymes">TDO2</a>, <a href="/t/arginase-1-arg1/proteins-enzymes">ARG1</a>, and <a href="/t/arginase-2-arg2/proteins-enzymes">ARG2</a></p> <p>• Highly active, angiogenesis-promoting matrix metalloproteinases, including <a href="/t/mmp-2/proteins-enzymes">MMP-2</a>, <a href="/t/mmp-9?category_attr=Proteins%20and%20Enzymes">MMP-9</a>, and <a href="/t/mmp-14-mt1-mmp/proteins-enzymes">MT1-MMP/MMP-14</a>, and broad spectrum and selective <a href="/search?keywords=mmp%20inhibitors&view=condensed&brand=tocris">MMP inhibitors</a></p> <p>• The ectoenzymes, <a href="/t/cd39-entpd1/proteins-enzymes">CD39</a> and <a href="/search?keywords=cd73&view=condensed&category_attr=Proteins%20and%20Enzymes&common_name=5u0027-Nucleotidase/CD73">CD73</a>, which generate extracellular adenosine and contribute to immunosuppression in the tumor microenvironment</p> <p>• A wide range of metabolic enzymes and inhibitors for investigating metabolic alterations in tumor cells</p> <p>• A complete collection of <a href="/search?keywords=kinase&view=condensed&category_attr=Proteins%20and%20Enzymes">kinases</a> and <a href="/search?keywords=kinase%20inhibitors&view=condensed&brand=tocris&category_attr=Small%20Molecules%20and%20Peptides">kinase inhibitors</a> for exploring cancer cell signaling pathways</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/search?keywords=immunotherapyenzymes&category_attr=Proteins%20and%20Enzymes" class="btn btn-primary" type="link"> View Immunotherapy-related Enzymes </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/images/webinar/LP_images/Protein-Bioprocessing-LP-Characterization-Enzyme.png" alt="Protein Bioprocessing: we offer a selection of flexible and fully-integrated solutions for your workflow." loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--dark"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/banners/bt-gmp-proteins-hero-banner-1500x340.jpg" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/custom-protein-library-teaser-solo.png" alt="Ribbon structure of a recombinant protein" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h2>PNGase F N-Glycan Releasing Kit</h2></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>N-glycosylation is a post-translational modification that can affect protein structures and functions, including receptor binding, cell signaling, pathogenicity, and immune recognition. This kit provides PNGase F and the buffers needed to release N-glycans from glycoproteins for gel and mass spectrometry analysis.</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/p/elisa-kits/pngase-f-n-glycan-releasing-kit_ea006" class="btn btn-primary" type="link"> Explore PNGase F Kit </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="kinases"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/kinases-phosphatases-illustration-v3.png" alt="Kinases Phosphatases Illustration" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h3>Kinases and Phosphatases</h3></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>• A large selection of active intracellular <a href="/search?keywords=kinase&category_attr=Proteins%20and%20Enzymes">kinases</a>, including <a href="/t/erk1/proteins-enzymes">ERK1</a>, <a href="/t/erk2/proteins-enzymes">ERK2</a>, <a href="/t/mek2/proteins-enzymes">MEK2</a>, <a href="/search?keywords=p38&category_attr=Proteins%20and%20Enzymes">p38</a>, and <a href="/t/ask1/proteins-enzymes">ASK1</a> for studying protein phosphorylation</p> <p>• The largest selection of potent and selective <a href="/search?keywords=kinase%20inhibitor&brand=tocris&category_attr=Small%20Molecules%20and%20Peptides">kinase inhibitors</a></p> <p>• A substantial collection of <a href="/search?keywords=phosphatase&category_attr=Proteins%20and%20Enzymes">phosphatases</a> and <a href="/search?keywords=phosphatase%20inhibitor&brand=tocris&category_attr=Small%20Molecules%20and%20Peptides">phosphatase inhibitors</a> for investigating the effects of protein dephosphorylation</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/search?keywords=kinasesphosphatases&category_attr=Proteins%20and%20Enzymes" class="btn btn-primary" type="link"> Search Our Kinases and Phosphatases </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid 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