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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-11-14T16:25:51.764">November 14, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Impact of RSV on Hospitalizations in US Adults Prior to Vaccine Introduction</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/pearl-steinzor">Pearl Steinzor</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Impact of RSV on Hospitalizations in US Adults Prior to Vaccine Introduction" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" 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viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">Respiratory syncytial virus (RSV) caused significant hospitalizations and severe outcomes in adults, especially those aged 75 years and older.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">A study analyzing data from October 2016 to September 2023 revealed a substantial burden of <a target="_blank" href="https://www.ajmc.com/compendium/rsv">respiratory syncytial virus</a> (RSV) in hospitalized US adults before the rollout of the 2023 RSV vaccines, suggesting that increasing RSV vaccination among older adults could help reduce severe clinical outcomes and health care burdens.<sup class="text-inherit">1</sup></p><div class=""><div style="width:33%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%275404%27%20height=%273602%27/%3e"/></span><img alt="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" title="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" title="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fe8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><div style="text-align:center">The researchers believe the findings underscore the significant burden of RSV in the older adult population prior to the introduction of vaccines. | Image credit: angellodeco - stock.adobe.com</div></p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">The cross-sectional study is published in <em><a rel="nofollow noreferrer noopener" target="_blank" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2826104?resultClick=1">JAMA Network Open</a>.</em></p><p class="pb-2"></p><p class="pb-2">“This analysis used 2016 to 2023 data from the population-based RSV Hospitalization Surveillance Network (RSV-NET) to describe the demographic characteristics of adults 18 years or older hospitalized with laboratory-confirmed RSV and to estimate rates and numbers of RSV-associated hospitalizations, intensive care unit (ICU) admissions, and in-hospital deaths,” the researchers of the study wrote.</p><p class="pb-2"></p><p class="pb-2">On June 26, 2024, the CDC’s Advisory Committee on Immunization Practices (ACIP) updated its recommendations that all adults aged 75 and older and adults 60 to 74 years who are at increased risk for severe RSV should receive a single dose of the RSV vaccine (Arexvy [GSK], Abrysvo [Pfizer], or mResvia [Moderna]).<sup class="text-inherit">2</sup></p><p class="pb-2"></p><p class="pb-2">RESP-NET conducts population-based surveillance of RSV, COVID-19, and influenza hospitalizations in the US.<sup class="text-inherit">1</sup> The data captured laboratory-confirmed RSV-associated hospitalizations from 58 counties in 12 states, covering about 8% of the US population. Eligible participants included nonpregnant adults 18 years or older who had a positive RSV test result during hospitalization or within 14 days prior.</p><p class="pb-2"></p><p class="pb-2">The primary outcome of the study was the burden of RSV in US adults, measured by the rates of RSV-associated hospitalizations, ICU admissions, and in-hospital deaths.</p><p class="pb-2"></p><p class="pb-2">Between the 2016-2017 and 2022-2023 RSV seasons, the study identified a total of 16,575 laboratory-confirmed RSV-associated hospitalizations, with reverse transcription polymerase chain reaction (RT-PCR) being the primary diagnostic test (98.7%). Additionally, a significant majority of patients (62.6%) were 65 or older.</p><p class="pb-2"></p><p class="pb-2">Hospitalization rates peaked in January each year, with notable disruptions during the COVID-19 pandemic. ICU admissions occurred in 19.1% of cases, and 4.3% of patients died in the hospital, with the highest mortality rate (5.8%) observed in adults 75 years or older.</p><p class="pb-2"></p><p class="pb-2">Testing practices improved over time, increasing from 30.4% of hospitalized adults in 2016-2017 to over 60% in 2022-2023. The unadjusted hospitalization rate ranged from 8.8 to 21.2 per 100,000 adults, while adjusted rates varied significantly by age, peaking among adults 75 years or older. The estimated number of annual RSV-associated hospitalizations ranged from 123,000 in 2016-2017 to 193,000 in 2017-2018, with ICU admissions and in-hospital deaths also showing substantial burden.</p><p class="pb-2"></p><p class="pb-2">Older adults, especially those 75 years and older, accounted for most severe outcomes, representing 45.6% of hospitalizations, 38.6% of ICU admissions, and 58.7% of in-hospital deaths.</p><p class="pb-2"></p><p class="pb-2">However, the researchers acknowledged several limitations. First, RSV testing was based on clinicians' discretion, potentially leading to an underestimation of the true RSV burden. Although adjustments were made for testing practices and test sensitivity, the underlying assumptions may be incorrect. Therefore, the burden estimates could be biased. Additionally, the analysis did not include nonrespiratory complications of RSV or assess primary reasons for hospitalization. Lastly, RSV-NET data may not be fully generalizable to the entire US population.</p><p class="pb-2"></p><p class="pb-2">Despite these limitations, the researchers believe the findings underscore the significant burden of RSV in the older adult population before introducing vaccines.</p><p class="pb-2"></p><p class="pb-2">“The study found that most hospitalizations occurred among older adults, with the highest hospitalization rates in those aged 75 years or older,” wrote the researchers. “Given the large numbers of potentially vaccine-preventable hospitalizations and deaths associated with RSV, increasing vaccine coverage among adults at highest risk could reduce associated hospitalizations and severe clinical outcomes.”</p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Havers FP, Whitaker M, Melgar M, et al. Burden of respiratory syncytial virus–associated hospitalizations in US adults, October 2016 to September 2023. <em>JAMA Netw Open.</em> 2024;7(11):e2444756. doi:10.1001/jamanetworkopen.2024.44756</p><p class="pb-2">2. Steinzor P. FDA approves Abrysvo RSV vaccine for adults at increased risk. <em>AJMC</em><sup class="text-inherit">®</sup><em>. </em>October 23, 2024. Accessed November 14, 2024. <a target="_blank" href="https://www.ajmc.com/view/fda-approves-abrysvo-rsv-vaccine-for-adults-at-increased-risk">https://www.ajmc.com/view/fda-approves-abrysvo-rsv-vaccine-for-adults-at-increased-risk</a>.</p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" 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text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 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Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format" alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"> RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f7e04cbc83dfad74d8bdb0df2c82f0d80ff4f7ea-4160x2981.jpg?fit=crop&auto=format" alt="STI test | Image credit: Saiful52 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent">STI Epidemic May Be Slowing, CDC Data Suggest</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Latest data from the CDC shows signs that the number of sexually transmitted infections (STIs) is declining. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent">Elevating Equitable Health Care for the LGBTQ+ Community</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format" alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"> RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f7e04cbc83dfad74d8bdb0df2c82f0d80ff4f7ea-4160x2981.jpg?fit=crop&auto=format" alt="STI test | Image credit: Saiful52 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent">STI Epidemic May Be Slowing, CDC Data Suggest</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/sti-epidemic-may-be-slowing-cdc-data-suggests?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Latest data from the CDC shows signs that the number of sexually transmitted infections (STIs) is declining. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Impact of RSV on Hospitalizations in US Adults Prior to Vaccine Introduction","datePublished":"2024-11-14T16:25:51.764Z","dateModified":"2024-11-14T18:23:44Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/e8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"RSV hospitalizations in adults,RSV burden in older adults,RSV vaccine","articleBody":"A study analyzing data from October 2016 to September 2023 revealed a substantial burden of respiratory syncytial virus (RSV) in hospitalized US adults before the rollout of the 2023 RSV vaccines, suggesting that increasing RSV vaccination among older adults could help reduce severe clinical outcomes and health care burdens.1\n\n\n\nThe cross-sectional study is published in JAMA Network Open.\n\n\n\n“This analysis used 2016 to 2023 data from the population-based RSV Hospitalization Surveillance Network (RSV-NET) to describe the demographic characteristics of adults 18 years or older hospitalized with laboratory-confirmed RSV and to estimate rates and numbers of RSV-associated hospitalizations, intensive care unit (ICU) admissions, and in-hospital deaths,” the researchers of the study wrote.\n\n\n\nOn June 26, 2024, the CDC’s Advisory Committee on Immunization Practices (ACIP) updated its recommendations that all adults aged 75 and older and adults 60 to 74 years who are at increased risk for severe RSV should receive a single dose of the RSV vaccine (Arexvy [GSK], Abrysvo [Pfizer], or mResvia [Moderna]).2\n\n\n\nRESP-NET conducts population-based surveillance of RSV, COVID-19, and influenza hospitalizations in the US.1 The data captured laboratory-confirmed RSV-associated hospitalizations from 58 counties in 12 states, covering about 8% of the US population. Eligible participants included nonpregnant adults 18 years or older who had a positive RSV test result during hospitalization or within 14 days prior.\n\n\n\nThe primary outcome of the study was the burden of RSV in US adults, measured by the rates of RSV-associated hospitalizations, ICU admissions, and in-hospital deaths.\n\n\n\nBetween the 2016-2017 and 2022-2023 RSV seasons, the study identified a total of 16,575 laboratory-confirmed RSV-associated hospitalizations, with reverse transcription polymerase chain reaction (RT-PCR) being the primary diagnostic test (98.7%). Additionally, a significant majority of patients (62.6%) were 65 or older.\n\n\n\nHospitalization rates peaked in January each year, with notable disruptions during the COVID-19 pandemic. ICU admissions occurred in 19.1% of cases, and 4.3% of patients died in the hospital, with the highest mortality rate (5.8%) observed in adults 75 years or older.\n\n\n\nTesting practices improved over time, increasing from 30.4% of hospitalized adults in 2016-2017 to over 60% in 2022-2023. The unadjusted hospitalization rate ranged from 8.8 to 21.2 per 100,000 adults, while adjusted rates varied significantly by age, peaking among adults 75 years or older. The estimated number of annual RSV-associated hospitalizations ranged from 123,000 in 2016-2017 to 193,000 in 2017-2018, with ICU admissions and in-hospital deaths also showing substantial burden.\n\n\n\nOlder adults, especially those 75 years and older, accounted for most severe outcomes, representing 45.6% of hospitalizations, 38.6% of ICU admissions, and 58.7% of in-hospital deaths.\n\n\n\nHowever, the researchers acknowledged several limitations. First, RSV testing was based on clinicians' discretion, potentially leading to an underestimation of the true RSV burden. Although adjustments were made for testing practices and test sensitivity, the underlying assumptions may be incorrect. Therefore, the burden estimates could be biased. Additionally, the analysis did not include nonrespiratory complications of RSV or assess primary reasons for hospitalization. Lastly, RSV-NET data may not be fully generalizable to the entire US population.\n\n\n\nDespite these limitations, the researchers believe the findings underscore the significant burden of RSV in the older adult population before introducing vaccines.\n\n\n\n“The study found that most hospitalizations occurred among older adults, with the highest hospitalization rates in those aged 75 years or older,” wrote the researchers. “Given the large numbers of potentially vaccine-preventable hospitalizations and deaths associated with RSV, increasing vaccine coverage among adults at highest risk could reduce associated hospitalizations and severe clinical outcomes.”\n\n\n\n\n\nReferences\n\n1. Havers FP, Whitaker M, Melgar M, et al. Burden of respiratory syncytial virus–associated hospitalizations in US adults, October 2016 to September 2023. JAMA Netw Open. 2024;7(11):e2444756. doi:10.1001/jamanetworkopen.2024.44756\n\n2. Steinzor P. FDA approves Abrysvo RSV vaccine for adults at increased risk. AJMC®. October 23, 2024. Accessed November 14, 2024. https://www.ajmc.com/view/fda-approves-abrysvo-rsv-vaccine-for-adults-at-increased-risk.\n\n\n\n\n\n","description":"Respiratory syncytial virus (RSV) caused significant hospitalizations and severe outcomes in adults, especially those aged 75 years and older.","author":[{"@type":"Person","name":"Pearl Steinzor"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] 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ICU admissions occurred in 19.1% of cases, and 4.3% of patients died in the hospital, with the highest mortality rate (5.8%) observed in adults 75 years or older."}],"_type":"block","style":"normal","_key":"31aee9c247d7","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[]},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3da1496107180"}],"_type":"block","style":"normal","_key":"45bcf66ece5f","upload_doc":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"text":"Testing practices improved over time, increasing from 30.4% of hospitalized adults in 2016-2017 to over 60% in 2022-2023. The unadjusted hospitalization rate ranged from 8.8 to 21.2 per 100,000 adults, while adjusted rates varied significantly by age, peaking among adults 75 years or older. 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facilities and less socially vulnerable counties, highlighting disparities in vaccine uptake.\n\n• Limitations include voluntary reporting for influenza and RSV vaccines, potential reporting bias, and aggregated data preventing individual-level analysis.\n\n• Despite existing programs, more efforts are needed to address barriers and improve vaccination rates among nursing home residents.","title":"Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake ","thumbnail":{"_type":"mainImage","alt":"Nursing home care | Image credit: Kzenon - stock.adobe.com","asset":{"_ref":"image-316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840-jpg","_type":"reference"}},"_updatedAt":"2024-11-22T20:39:32Z","documentGroup":null,"ExcludeFromPubMedXML":false,"_type":"article","summary":"Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. ","_createdAt":"2024-11-22T20:16:33Z","gptSummary":"Nursing home residents are at increased risk for severe complications from respiratory viruses, yet vaccination rates for RSV, influenza, and COVID-19 remain low for the 2024–2025 season. Data from CMS-certified nursing homes show only 17.9% of residents received the RSV vaccine, 58.4% received the influenza vaccine, and 29.7% received the COVID-19 vaccine. Coverage varies by region and is generally higher in smaller facilities and less socially vulnerable counties. 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Influenza and RSV vaccination data were reported voluntarily, while COVID-19 vaccination reporting was mandatory.","_key":"6aa20a28c07f"}],"_type":"block","style":"normal","_key":"a54a651555f3"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\nVaccination coverage among nursing home residents was reported by 51.8% of facilities, with only 17.9% of residents receiving the vaccine. Coverage varied widely by region, from 9.3% in HHS Region 6 to 29.2% in HHS Region 8, and was highest in counties with lower social vulnerability (21.3%) and in smaller facilities (24.1%).","_key":"6aa9a95312e70"}],"_type":"block","style":"normal","_key":"242200872a9c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a3b4712b0f6f0"}],"_type":"block","style":"normal","_key":"4f23d31519ae"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Influenza vaccination coverage was voluntarily reported by 59.4% of facilities, with 58.4% of residents vaccinated. Coverage ranged from 50.9% in HHS Region 10 to 64.1% in HHS Region 1 and was higher in the least socially vulnerable counties (60.8%) and smaller facilities (62.9%).","_key":"6d6e2e1e43230"}],"_type":"block","style":"normal","_key":"655c13299ace"},{"markDefs":[],"children":[{"text":"","_key":"9b05c96fb9c70","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"ef79beabf256"},{"markDefs":[],"children":[{"text":"COVID-19 vaccination coverage, which was reported by 92.9% of facilities, remained low, with only 29.7% of residents receiving the 2024 to 2025 COVID-19 vaccine. Coverage was lowest in HHS Region 6 (19.8%) and highest in Region 8 (38.6%), with better rates observed in smaller facilities (34.7%) and less vulnerable counties (33.6%). These findings highlight substantial gaps in vaccine uptake, particularly for RSV and COVID-19.","_key":"2e9941b21abf0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"e026ae7211c9"},{"markDefs":[],"children":[{"_key":"b61eb94f9e580","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"54cc79d7a6ea"},{"markDefs":[],"children":[{"marks":[],"text":"However, the investigators noted some limitations. First, reporting of influenza and RSV vaccination coverage was voluntary, and facilities that chose to report may have had higher vaccination rates than those that did not, potentially biasing the results. Second, the increase in the number of facilities reporting influenza and RSV vaccination coverage compared with the previous season limited direct comparisons between seasons. Third, RSV vaccination coverage was calculated for residents of all ages, although approximately 91% of nursing home residents are aged 60 years and older, for whom the vaccine is recommended. Finally, vaccination data were aggregated, preventing assessment of individual-level factors influencing vaccine uptake, such as demographic or clinical characteristics.","_key":"a0321c48d9f60","_type":"span"}],"_type":"block","style":"normal","_key":"c7463e245961"},{"markDefs":[],"children":[{"_key":"8a018cb91a740","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"e2063803964a"},{"style":"normal","_key":"dc1de8833529","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite these limitations, these findings underscore the urgent need to boost vaccination efforts to safeguard one of the most vulnerable populations from preventable respiratory illnesses.","_key":"2435609055e90"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"4b5169f9282e0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"b158846d9f4c"},{"markDefs":[],"children":[{"text":"“Although CDC and other federal agencies have programs in place to address both the financial and vaccine hesitancy–related barriers to vaccination in nursing homes, more needs to be done at every level to protect nursing home residents, who constitute one of the population groups at highest risk for severe respiratory disease,” wrote the investigators.","_key":"499c0bfb4d2d0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"4c732e0da54e"},{"markDefs":[],"children":[{"text":"","_key":"c5e804155d1a0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"c10bc8ecf31f"},{"markDefs":[],"children":[{"text":"References","_key":"ef3b9dcea98d0","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"9aaf3d9a68fb"},{"_type":"block","style":"normal","_key":"8735f3f6f08a","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"http://dx.doi.org/10.15585/mmwr.mm7346a2","_key":"0b631d436eed"}],"children":[{"_type":"span","marks":[],"text":"1. Reses HE, Segovia G, Dubendris H, et al. Coverage with influenza, respiratory syncytial virus, and COVID-19 vaccines among nursing home residents — National Healthcare Safety Network, United States, November 2024. ","_key":"7b8f957b8f2e0"},{"_type":"span","marks":["em"],"text":"MMWR Morb Mortal Wkly Rep.","_key":"7b8f957b8f2e1"},{"_type":"span","marks":[],"text":" 2024;73:1052-1057. doi:","_key":"7b8f957b8f2e2"},{"_type":"span","marks":["0b631d436eed"],"text":"http://dx.doi.org/10.15585/mmwr.mm7346a2","_key":"7b8f957b8f2e3"}]},{"_type":"block","style":"normal","_key":"20ab0a0618e5","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.html","_key":"025b5ce4476d"}],"children":[{"_type":"span","marks":[],"text":"2. RSV vaccine guidance for older adults. CDC. August 30, 2024. Accessed November 22, 2024. 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The study was conducted to confirm RSV vaccine effectiveness found in clinical trials against lower respiratory tract disease using real world data.","_key":"5f21390bbfbd","_type":"span","marks":[]},{"_type":"span","marks":["superscript"],"text":"1","_key":"f41fbe9996d1"}]},{"markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"034898ed767f"}],"_type":"block","style":"normal","_key":"855f348fe562"},{"children":[{"_key":"0e2bd22cb7150","_type":"span","marks":[],"text":"According to the CDC, the US experiences up to 160,000 hospitalizations and around 10,000 deaths among older adults due to RSV infection each year. 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Gonorrhea cases notably declined by 7.2%, while chlamydia rates remained stable, and syphilis cases increased slightly by 1%. Disparities persist, with young individuals and men who have sex with men (MSM) disproportionately affected. The data highlights the need for continued innovation and investment in STI prevention, addressing inequities in healthcare access, and understanding sexual network dynamics to mitigate the impact of STIs.","gptTakeaways":"• The 2023 STI data shows a 1.8% overall decrease, with significant declines in gonorrhea cases and stable chlamydia rates.\n\n• Syphilis cases increased by 1%, with notable declines in primary and secondary syphilis but rises in late-stage cases.\n\n• Disparities in STI rates persist, affecting young individuals, MSM, and racial/ethnic minorities, highlighting healthcare access inequities.\n\n• Continued innovation and investment in STI prevention are crucial to address systemic barriers and reduce STI impact.","ExcludeFromPubMedXML":false,"body":[{"_type":"block","style":"normal","_key":"ad62d22b5e06","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Although more than 2.4 million cases of sexually transmitted infections (STIs) were reported in 2023, new data reveals promising signs that the epidemic is slowing.","_key":"92c0055d9b6f0"},{"_type":"span","marks":["superscript"],"text":"1","_key":"4e4a7de0306e"}]},{"disableLightBox":true,"alignment":"left","widthP":34,"_key":"30cd7a8832f0","disableTextWrap":false,"alt":"STI test | Image credit: Saiful52 - stock.adobe.com","asset":{"_ref":"image-f7e04cbc83dfad74d8bdb0df2c82f0d80ff4f7ea-4160x2981-jpg","_type":"reference"},"_type":"figure","imgcaption":[{"markDefs":[],"children":[{"text":"Latest data from the CDC shows signs that the number of sexually transmitted infections (STIs) is declining. | Image credit: Saiful52 - stock.adobe.com","_key":"cce5643c44f50","_type":"span","marks":["aligncenter"]}],"_type":"block","style":"normal","_key":"f3f8a254572d"}]},{"markDefs":[],"children":[{"marks":[],"text":"\"I see a glimmer of hope amidst millions of STIs,\" said Jonathan Mermin, MD, MPH, Director of CDC's National Center for HIV, Viral Hepatitis, STD, and TB Prevention, in a statement. \"After nearly 2 decades of STI increases, the tide is turning. We must make the most of this moment—let's further this momentum with creative innovation and further investment in STI prevention.\"","_key":"b1acdc5bfeb10","_type":"span"}],"_type":"block","style":"normal","_key":"cb3d3cbb5229"},{"_type":"block","style":"normal","_key":"9518713d5526","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b9fa15886e410"}]},{"_key":"cca9eed43fd5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In 2023, over 209,000 cases of syphilis, over 600,000 cases of gonorrhea, and over 1.6 million cases of chlamydia were reported.","_key":"7d18f8595d6b0"},{"_type":"span","marks":["superscript"],"text":"2 ","_key":"b3fe03dc8fc7"},{"_type":"span","marks":[],"text":"Moreover, the combined count of over 2.4 million STIs includes 3882 cases of congenital syphilis, including 279 congenital syphilis stillbirths and neonatal/infant deaths.","_key":"50896433e924"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"77ab43beb0f20"}],"_type":"block","style":"normal","_key":"bb3ee2e1b94e","markDefs":[]},{"style":"normal","_key":"fc921d04fd5b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Although the total number of STIs remains high, there was an overall decrease of 1.8% from 2022 to 2023. Gonorrhea cases fell by 7.2%, while chlamydia rates remained stable (change of less than 1%), and total syphilis cases increased by 1%.","_key":"4b51ca6452de0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3e6f93764d810"}],"_type":"block","style":"normal","_key":"59e81d751aa6"},{"_key":"87c24e855015","markDefs":[],"children":[{"_type":"span","marks":[],"text":"With 601,319 cases reported, gonorrhea was the second most common nationally notifiable STI in the US. in 2023. Following a historic low in 2009, gonorrhea rates rose through 2021 but showed consecutive declines of 9.2% from 2021 to 2022 and 7.7% from 2022 to 2023. Reductions were seen across most age groups, genders, and racial/ethnic populations in 40 states, with the steepest decline among women (14.1%), especially those aged 20 to 24 years (14.6%) and 25 to 29 years (19.2%).","_key":"6892b474051e0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c3c2e7b1dd2a0"}],"_type":"block","style":"normal","_key":"e94f0c7da5a0"},{"children":[{"_type":"span","marks":[],"text":"Since 2013, gonorrhea rates have been consistently higher among men than women, largely due to cases among men who have sex with men (MSM). Data from the STI Surveillance Network (SSuN) suggests that MSM accounted for about half of gonorrhea cases in 2023, though this varied by jurisdiction.","_key":"96ef6f73f04a0"}],"_type":"block","style":"normal","_key":"b31f6a1228fa","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"02ffbb0371710"}],"_type":"block","style":"normal","_key":"226f16c68b41"},{"style":"normal","_key":"c80cfa3ccfdd","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In 2023, there were 209,253 reported syphilis cases (all stages, including congenital), the highest number since 1950 and a 1.0% increase from 2022. This included:","_key":"b3e026216d1e0"}],"_type":"block"},{"children":[{"text":"53,007 primary and secondary (P\u0026S) syphilis cases (a 10.2% decrease from 2022)","_key":"6adfc95674b70","_type":"span","marks":[]}],"level":1,"_type":"block","style":"normal","_key":"d58599c61574","listItem":"bullet","markDefs":[]},{"level":1,"_type":"block","style":"normal","_key":"4a622386d667","listItem":"bullet","markDefs":[],"children":[{"text":"53,573 early non-primary, non-secondary syphilis cases (a 5.9% decrease)","_key":"072b0fbbbd420","_type":"span","marks":[]}]},{"style":"normal","_key":"755b9891b776","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"98,791 cases of unknown duration or late syphilis (a 12.8% increase)","_key":"8da7f8b65aad0"}],"level":1,"_type":"block"},{"_type":"block","style":"normal","_key":"8cb449e95aa0","listItem":"bullet","markDefs":[],"children":[{"_type":"span","marks":[],"text":"3882 congenital syphilis cases (a 3.0% increase)","_key":"eb8b21cd07330"}],"level":1},{"_type":"block","style":"normal","_key":"83b3070f9685","markDefs":[],"children":[{"_key":"1c46e44302440","_type":"span","marks":[],"text":""}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The overall syphilis case rate per 100,000 people remained stable (from 61.1 to 61.3), but trends differed by stage. The rate of P\u0026S syphilis fell by 10.7%, the first significant decline since 2001, with decreases across genders, age groups, and racial/ethnic populations in 41 states plus Washington D.C. However, the rate of unknown duration or late syphilis rose by 12.2%, possibly reflecting delayed diagnoses due to disruptions in STI services during the COVID-19 pandemic.","_key":"a4126ea7744c0"}],"_type":"block","style":"normal","_key":"e6aaed39bf69"},{"children":[{"_type":"span","marks":[],"text":"","_key":"a3040e6e4dfd0"}],"_type":"block","style":"normal","_key":"ee35156f1aaa","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"MSM accounted for 32.7% of all P\u0026S syphilis cases and 57.5% of cases among men with known sex partners in 2023. Notably, P\u0026S syphilis cases among MSM decreased by 13.4%, marking the first substantial decline in over 15 years, with reductions seen in both HIV-negative (8.5%) and HIV-positive MSM (11.4%).","_key":"feea4120cf1f0"}],"_type":"block","style":"normal","_key":"773b668a0318"},{"children":[{"_type":"span","marks":[],"text":"","_key":"12ca62f4a8c70"}],"_type":"block","style":"normal","_key":"a33ca7d1a863","markDefs":[]},{"style":"normal","_key":"9f1058cd531f","markDefs":[],"children":[{"text":"In 2023, disparities in STI rates remained significant. Nearly half (48.2%) of all cases of chlamydia, gonorrhea, and syphilis (all stages) were among individuals aged 15 to 24 years. MSM experienced a disproportionate burden of STIs, including gonorrhea and P\u0026S syphilis, with 37.2% of MSM diagnosed with P\u0026S syphilis also having HIV. Additionally, 32.4% of all reported cases of chlamydia, gonorrhea, and P\u0026S syphilis were among non-Hispanic Black or African American individuals, who make up only 12.6% of the US population. Rates of P\u0026S syphilis and congenital syphilis were highest among American Indian or Alaska Native individuals.","_key":"33adb43c2d1c0","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"7db61a0710b1","markDefs":[],"children":[{"text":"","_key":"427bfcb193b90","_type":"span","marks":[]}],"_type":"block"},{"_key":"f533f3f91e62","markDefs":[],"children":[{"text":"These disparities likely reflect not only differences in sexual behavior but also inequities in access to quality sexual health care and variations in sexual network dynamics.","_key":"b5c10d98ded10","_type":"span","marks":[]},{"_key":"1ed6410c2926","_type":"span","marks":["superscript"],"text":"1"},{"_type":"span","marks":[],"text":" In communities with higher STI prevalence, individuals face a greater risk of encountering an infected partner, regardless of similar sexual behavior patterns. 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