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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">Commentary</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Video</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-09-17T19:49:02.503">September 17, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Promising Clinical Trial Updates in IPF/PPF</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/pearl-steinzor">Pearl Steinzor</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Promising Clinical Trial Updates in IPF/PPF" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" 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M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"><div class="related-landing sm:w-auto md:max-w-fit lg:w-[auto] md:text-center my-2 md:my-0 undefined"><a class="" href="/conference/ers"><div class="mt-6"><span class="text-primary text-sm">Conference</span><span class="mx-1 text-sm">|</span><span class="text-sm text-blue-700 underline">ERS: European Respiratory Society</span></div></a></div></div><p class="py-2 mb-2 text-sm italic text-gray-600">Toby Maher, MD, PhD, professor of clinical medicine, Keck Medicine of USC, discusses recent advancements in clinical trials for patients with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><div class="relative"><div class="brightcove-fluid" autoplay=""></div></div><p class="pb-2">It is important to explore the extended safety profile as well as the long-term efficacy of new drugs in patients with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF), says Toby Maher, MD, PhD, professor of clinical medicine, Keck Medicine of USC. </p><p class="pb-2"></p><p class="pb-2"><strong><span style="text-decoration:underline">Transcript</span></strong></p><p class="pb-2"><strong>Can you discuss the design of the FIBRONEER-ON open-label extension trial?</strong></p><p class="pb-2">The FIBRONEER-ON open-label extension trial is a follow-on from 2 clinical trials, the FIBRONEER trial in patients with idiopathic pulmonary fibrosis and the FIBRONEER trial in patients with progressive pulmonary fibrosis. Both of those studies contain over 1000 participants per trial. In those trials, patients are on either placebo or 1 of 2 doses of nerandomilast, which is a PDE4B inhibitor. In the FIBRONEER-ON trial, we're going to be rolling patients over from those 2 trials so that everybody receives open-label treatment with neradomilast. What we're looking for in that trial is to understand the extended safety profile of the drug and at the same time, to also try and gain further understanding about long-term efficacy.</p><p class="pb-2"></p><p class="pb-2"><strong>What were the key findings regarding the effects of lysophosphatidic acid receptor 1 (LPA1) antagonism with BMS-98627 on biomarkers in patients with IPF and PPF?</strong></p><p class="pb-2">Thankfully, they've given that drug a name; it's now admilparant. It's an LPA receptor 1 antagonist. There's good preclinical evidence that the LPA receptor pathway plays an important role in driving fibrosis. In that particular trial, that was a phase 2b trial where we explored 2 doses of treatment compared to placebo, in 2 separate cohorts of patients; 1 group who had idiopathic pulmonary fibrosis, the other group who had progressive pulmonary fibrosis. We looked at both sets of patients separately, but the results were pretty consistent across both groups. The higher dose of admilparant, the 60-mg daily dose, appeared to slow the rate of FVC [forced vital capacity] decline compared to placebo, and that was over 6 months of treatment. And so, as a phase 2 study, that really was to allow us to make the decision about going into phase 3, and there are now separate clinical trials at phase 3 looking at admilparant in patients with either IPF or progressive pulmonary fibrosis.</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" 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href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448.jpg?fit=crop&auto=format" alt="Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent">Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/758a0de566362b3ad859754c1250dd77346ec42d-1200x738.jpg?fit=crop&auto=format" alt="Christopher Sayed, MD, UNC Chapel Hill" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">BE HEARD Trials Highlight Efficacy of Bimekizumab in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On November 20, the FDA approved bimekizumab (Bimzelx; UCB Pharma) for use in patients with moderate to severe hidradenitis suppurativa.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1593b9084e200d929c984e7607fbdfb8e2f5b8d3-300x168.png?fit=crop&auto=format" alt="AHA 100 Years logo | Image: AHA" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">Vertical Integration in Cardiology Brings Less Value, Analysis Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The poster session, “Behind the Curtain: How Healthcare Policy Shapes Patient Outcomes,” took place on the final day of the American Heart Association Scientific Session.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448.jpg?fit=crop&auto=format" alt="Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent">Facility Type Influences Antifibrotic Treatment Rates in Patients With IPF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/facility-type-influences-antifibrotic-treatment-rates-in-patients-with-ipf?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study in Japan found that antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent">Operationalizing Bispecifics in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/operationalizing-bispecifics-in-multiple-myeloma?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Tyler Sandahl, PharmD, of Mayo Clinic, and Michael Byrne, DO, of Tennessee Oncology, discuss practical advice for bringing bispecifics to the community.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/758a0de566362b3ad859754c1250dd77346ec42d-1200x738.jpg?fit=crop&auto=format" alt="Christopher Sayed, MD, UNC Chapel Hill" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">BE HEARD Trials Highlight Efficacy of Bimekizumab in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/be-heard-trials-highlight-efficacy-of-bimekizumab-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On November 20, the FDA approved bimekizumab (Bimzelx; UCB Pharma) for use in patients with moderate to severe hidradenitis suppurativa.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent">Expert Insights on How Utilization Management Drives Physician Burnout</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-insights-on-how-utilization-management-drives-physician-burnout?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with the author of a study published in the November 2024 issue of The American Journal of Managed Care® to explore the link between utilization management and physician burnout. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1593b9084e200d929c984e7607fbdfb8e2f5b8d3-300x168.png?fit=crop&auto=format" alt="AHA 100 Years logo | Image: AHA" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent">Vertical Integration in Cardiology Brings Less Value, Analysis Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/vertical-integration-in-cardiology-brings-less-value-analysis-finds?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The poster session, “Behind the Curtain: How Healthcare Policy Shapes Patient Outcomes,” took place on the final day of the American Heart Association Scientific Session.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Promising Clinical Trial Updates in IPF/PPF","datePublished":"2024-09-17T19:49:02.503Z","dateModified":"2024-09-17T19:49:05Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/1bf7c5537f1a14b980bc6f4b1f955a8fe75364c1-2704x1522.png?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/promising-clinical-trial-updates-in-ipf-ppf"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Nerandomilast,IPF Clinical Trials,IPF/PPF Clinical Trials","articleBody":"\n\nIt is important to explore the extended safety profile as well as the long-term efficacy of new drugs in patients with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF), says Toby Maher, MD, PhD, professor of clinical medicine, Keck Medicine of USC. \n\n\n\nTranscript\n\nCan you discuss the design of the FIBRONEER-ON open-label extension trial?\n\nThe FIBRONEER-ON open-label extension trial is a follow-on from 2 clinical trials, the FIBRONEER trial in patients with idiopathic pulmonary fibrosis and the FIBRONEER trial in patients with progressive pulmonary fibrosis. Both of those studies contain over 1000 participants per trial. In those trials, patients are on either placebo or 1 of 2 doses of nerandomilast, which is a PDE4B inhibitor. In the FIBRONEER-ON trial, we're going to be rolling patients over from those 2 trials so that everybody receives open-label treatment with neradomilast. What we're looking for in that trial is to understand the extended safety profile of the drug and at the same time, to also try and gain further understanding about long-term efficacy.\n\n\n\nWhat were the key findings regarding the effects of lysophosphatidic acid receptor 1 (LPA1) antagonism with BMS-98627 on biomarkers in patients with IPF and PPF?\n\nThankfully, they've given that drug a name; it's now admilparant. It's an LPA receptor 1 antagonist. There's good preclinical evidence that the LPA receptor pathway plays an important role in driving fibrosis. In that particular trial, that was a phase 2b trial where we explored 2 doses of treatment compared to placebo, in 2 separate cohorts of patients; 1 group who had idiopathic pulmonary fibrosis, the other group who had progressive pulmonary fibrosis. We looked at both sets of patients separately, but the results were pretty consistent across both groups. The higher dose of admilparant, the 60-mg daily dose, appeared to slow the rate of FVC [forced vital capacity] decline compared to placebo, and that was over 6 months of treatment. And so, as a phase 2 study, that really was to allow us to make the decision about going into phase 3, and there are now separate clinical trials at phase 3 looking at admilparant in patients with either IPF or progressive pulmonary fibrosis.","description":"Toby Maher, MD, PhD, professor of clinical medicine, Keck Medicine of USC, discusses recent advancements in clinical trials for patients with idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). 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IPF."}],"_type":"block","style":"normal","_key":"0f32077b8479"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"c647fe9caecb0","_type":"span"}],"_type":"block","style":"normal","_key":"556622a68323"},{"style":"normal","_key":"185ec7c45c7d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite these benefits, an online survey of respiratory physicians across Europe found that 54% of those with IPF were not receiving antifibrotic therapy. The researchers noted that many untreated patients had mild IPF, indicating a lack of proactive treatment.","_key":"1786ff5389d00"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ba73852589c10"}],"_type":"block","style":"normal","_key":"bd544b033879"},{"markDefs":[],"children":[{"_key":"5579653999780","_type":"span","marks":[],"text":"Conversely, some cases present challenges for initiating antifibrotic therapy, and poor PS can hinder treatment continuation; starting therapy in patients with preserved PS is preferable. Building on past research, the researchers surveyed general practitioners and respiratory physicians in Japan to determine the proportion of untreated patients with IPF and factors associated with nonintervention."}],"_type":"block","style":"normal","_key":"66c63c57ca1a"},{"alignment":"right","disableTextWrap":false,"disableLightBox":true,"widthP":40,"alt":"Exterior of a hospital | Image Credit: Spiroview Inc. - stock.adobe.com","imgcaption":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Antifibrotic treatment rates for patients with idiopathic pulmonary fibrosis (IPF) varied by medical facility, with higher treatment rates observed in referral hospitals than in general hospitals or clinics. | Image Credit: Spiroview Inc. - stock.adobe.com","_key":"2b83b0b08ece"}],"_type":"block","style":"normal","_key":"308532b7e3b2"}],"asset":{"_ref":"image-f1dd6b59e85295091f77dfc0c25fdeb8a9856a93-4592x3448-jpg","_type":"reference"},"_type":"figure","_key":"2939b480fd65"},{"markDefs":[],"children":[{"marks":[],"text":"The study was conducted at 23 medical facilities (9 clinics, 12 general hospitals, 1 university hospital, and 1 specialized respiratory hospital) in Yamaguchi, Japan, from December 2019 to October 2020. The researchers included patients diagnosed with IPF at the study facility.","_key":"92476cdfcdbf0","_type":"span"}],"_type":"block","style":"normal","_key":"218de00e81b4"},{"markDefs":[],"children":[{"text":"","_key":"5c74ca26fc0a0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"e0ebc73c01cc"},{"style":"normal","_key":"7e25fab5b342","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Both physicians and patients conducted the surveys. Patients completed a 3-item questionnaire on PS, cough symptom severity, and the modified Medical Research Council (mMRC) scale. In contrast, physicians recorded patients' demographic data, clinical characteristics, and IPF diagnoses. They also recorded clinical examination data, treatment details, when treatment started, and why; for those who did not receive treatment, the physicians recorded the reasons why.","_key":"32a68fa996790"}],"_type":"block"},{"_key":"5df46ffb0cc2","markDefs":[],"children":[{"text":"","_key":"8a631a22d4fb0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Physicians in the specialized respiratory and university hospitals also asked about the time from diagnosis at other facilities to referral, pulmonary function test (PFT) results, and Krebs von den Lungen 6 (KL-6) and surfactant protein D (Sp-D) values at the initial visit. ","_key":"777ac23244e30"}],"_type":"block","style":"normal","_key":"24cdddf66e01"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7c39b5f03be4"}],"_type":"block","style":"normal","_key":"8d63c4c5ab36"},{"markDefs":[],"children":[{"_key":"2ecfffb092c6","_type":"span","marks":[],"text":"The researchers performed a principal component analysis (PCA) using 15 clinical variables, including age, sex, medical facility, body mass index (BMI), specialized tests, and symptom severity. In the PCA plots, the researchers evaluated the distribution of clinical variables vs antifibrotic treatment."}],"_type":"block","style":"normal","_key":"ed023c3455f7"},{"markDefs":[],"children":[{"_key":"e78245645f0a0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"1b5aff0d650c"},{"style":"normal","_key":"5f9e9f8aea0d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers enrolled 518 patients with interstitial lung disease (ILD) in the study, 207 of whom were diagnosed with IPF. Among these 207 patients, 168 had a good PS, or a PS of 2 or less, which could indicate their treatment eligibility. Their mean (SD) age was 76.5 (8.2), and most (72.6%) were male. Also, 125 (74%) received treatment at a general hospital, 29 (17%) at either a specialized respiratory or a university hospital, and 14 (8%) at a clinic.","_key":"72be55df72210"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"d2dda4277fa10"}],"_type":"block","style":"normal","_key":"8a0422349fc3","markDefs":[]},{"style":"normal","_key":"857ca7efc518","markDefs":[],"children":[{"text":"Of those with IPF, 39 (22.6%) received an antifibrotic drug. The PCA determined that the rate of antifibrotic treatment was significantly higher in referral hospitals than in clinics or general hospitals. Based on physicians’ questionnaires, most did not prescribe antifibrotic drugs due to mild symptoms, imaging findings, or oxygenation, with no differences between facilities. ","_key":"f402874016ac0","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"9a3542063244","markDefs":[],"children":[{"marks":[],"text":"","_key":"c5ae02e7402f","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"c1b9ce7e0a5d","_type":"span","marks":[],"text":"However, for those who received antifibrotic drugs, the time from diagnosis to treatment in referral hospitals (16 cases) and general hospitals (20 cases) was a mean (SD) of 24.5 (35.7) and 35.5 (40.0) months, respectively; there were no significant differences."}],"_type":"block","style":"normal","_key":"558459c819ac"},{"children":[{"_type":"span","marks":[],"text":"","_key":"31a7e09702620"}],"_type":"block","style":"normal","_key":"405c9cc5899e","markDefs":[]},{"_key":"6d62900c1858","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers found that treatment rates were significantly higher among patients with poor PS, higher mMRC scores, and long-term oxygen therapy (LTOT) users (","_key":"3bea81611d950"},{"_key":"3bea81611d951","_type":"span","marks":["em"],"text":"P "},{"marks":[],"text":"\u003c .0001). Therefore, symptom severity is a relevant factor for therapeutic intervention decisions in general hospitals. Conversely, treatment rates in referral hospitals were not associated with PS, mMRC score, or LTOT use; symptom severity is not considered when deciding on therapeutic intervention in this setting.","_key":"3bea81611d952","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"c6d313d6b853","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2143012e56060"}]},{"children":[{"_type":"span","marks":[],"text":"The researchers acknowledged their limitations, one being that they conducted their study in a rural part of Japan rather than an urban area. Therefore, it cannot be considered an overall assessment of the country. Similarly, because it only analyzed patients within Japan, the findings may not be generalizable to other populations. Despite this, the researchers expressed confidence in their findings.","_key":"733fa6ec90cb0"}],"_type":"block","style":"normal","_key":"0fcce14fd947","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"ec99bb31c7f20"}],"_type":"block","style":"normal","_key":"c123d1713c4c","markDefs":[]},{"_type":"block","style":"normal","_key":"673ca5ee1f79","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Our findings indicate that further awareness of the indications for antifibrotic therapy in mild cases of IPF and collaboration between general and specialized hospitals are required,” the authors concluded.","_key":"6782f7edc4e90"}]},{"_type":"block","style":"normal","_key":"6912c26a1eb1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0dfe505ed68c0"}]},{"markDefs":[],"children":[{"_key":"de858caaf4a60","_type":"span","marks":["strong"],"text":"References"}],"_type":"block","style":"normal","_key":"7e5e3dae0a29"},{"style":"normal","_key":"a3c3837dd0f9","listItem":"number","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Asami-Noyama M, Hamada K, Asai Y, et al. 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Despite the benefits of pirfenidone and nintedanib, many patients with mild IPF remain untreated, often due to mild symptoms or imaging findings. The study, conducted in Yamaguchi, Japan, highlights the need for increased awareness of antifibrotic therapy indications and better collaboration between general and specialized hospitals. 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There are other IL-17 antagonists that are out there that mostly have tried to go after and block IL-17A, which is very important in conditions like psoriasis and other inflammatory diseases, but there's another type of IL-17 called IL-17F. And while it's not sort of as potent at causing inflammation, there's just so much of it around that if you don't block it, you tend to see continued inflammation in those patients.","_key":"2d4341db6b520"}],"_type":"block"},{"children":[{"marks":[],"text":"","_key":"2f5ca6ff7c770","_type":"span"}],"_type":"block","style":"normal","_key":"5df1beed20c8","markDefs":[]},{"style":"normal","_key":"8b18cf35a776","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So by blocking both A and F, you get a more complete blockade of the type of inflammation that drives these kinds of conditions, and in some instances, that seems to translate into improvement in symptoms overall. 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kieferpix - stock.adobe.com.jpg"},"published":"2024-11-26T16:10:18.871Z"}]},{"taxonomyMapping":[{"_createdAt":"2020-03-30T19:06:53Z","_rev":"Zzg2CQjl4x3UedGJkY3tyu","name":"Conference","identifier":"conference","_updatedAt":"2022-07-31T01:47:04Z","parent":null,"pixelTrackingCode":null,"_type":"taxonomy","_id":"1862ee25-8e65-4dbe-8fd3-d4c11642b211"}],"url":"vertical-integration-in-cardiology-brings-less-value-analysis-finds","factCheckAuthorMapping":null,"summary":"The poster session, “Behind the Curtain: How Healthcare Policy Shapes Patient Outcomes,” took place on the final day of the American Heart Association Scientific Session.","_type":"article","body":[{"_type":"block","style":"normal","_key":"7586660408c2","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.ajmc.com/conference/aha","_key":"a4f0648b22f4"}],"children":[{"_type":"span","marks":[],"text":"Vertical integration, which has consolidated independent cardiologists into hospital systems over the past 15 years, has led to higher costs in Medicare with “minimal evidence” of any increase in quality, according to findings presented during the recent 2024 ","_key":"dc76ff2ef1720"},{"marks":["a4f0648b22f4"],"text":"American Heart Association","_key":"2d35fd1904eb","_type":"span"},{"_type":"span","marks":[],"text":" (AHA) Scientific Sessions in Chicago, Illinois.","_key":"13e7b3101e1b"},{"marks":["superscript"],"text":"1","_key":"ba2f4efcd981","_type":"span"}]},{"children":[{"marks":[],"text":"The analysis, “The Association of Cardiologist Vertical Integration With Care Quality, Patient Outcomes, and Utilization,” was presented by as part of the poster session, “Behind the Curtain: How Healthcare Policy Shapes Patient Outcomes,” which took place on the final day of the AHA sessions, Monday, November 18, 2024.","_key":"5adfd183cc9b0","_type":"span"}],"_type":"block","style":"normal","_key":"2c1edda343b6","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"The findings were simultaneously reported in the ","_key":"1c1d37dc23280"},{"marks":["em","e23a4fd03ceb"],"text":"Journal of the American College of Cardiology","_key":"1c1d37dc23281","_type":"span"},{"_key":"1c1d37dc23282","_type":"span","marks":[],"text":"."},{"_type":"span","marks":["superscript"],"text":"2","_key":"5eae91c609f0"}],"_type":"block","style":"normal","_key":"7ceca9ba5b23","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.jacc.org/doi/10.1016/j.jacc.2024.10.109","_key":"e23a4fd03ceb"}]},{"alt":"Vinay Kini, MD, MSc | Image credit: Weill Cornell Medicine","disableLightBox":true,"_type":"figure","imgcaption":[{"style":"normal","_key":"a0f029369154","markDefs":[],"children":[{"marks":[],"text":"Vinay Kini, MD, MSc | Image credit: Weill Cornell Medicine","_key":"345f9692c1f7","_type":"span"}],"_type":"block"}],"_key":"2bcd79512020","asset":{"_ref":"image-113a2f66774360668b6672f7627f1f2bbd45b9a8-480x561-jpg","_type":"reference"},"disableTextWrap":false,"alignment":"left","widthP":25},{"_type":"block","style":"normal","_key":"3b066d64aeef","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study’s senior author and presenter, Vinay Kini, MD, MSc, a cardiologist and health services researcher with Weill Cornell Medicine, acknowledged that the results mean those paying for Medicare cardiology services are receiving less value due to consolidation.","_key":"e5b8ef1add8a0"}]},{"_type":"block","style":"normal","_key":"dd38b68d07db","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Kini said the study was designed to measure if the purported benefits of vertical integration result in better quality care. First, he explained how consolidation of the supply chain in health care can take different forms, from physician practices affiliating with hospitals to physicians becoming direct employees of the hospitals. Data presented showed that the percentage of US cardiologists employed by hospitals increased from 26% in 2008 to 61% in 2018.","_key":"1253c826960b0"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"a6dccc03bfc5"}]},{"_key":"e389fb5cc7cd","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Proponents of integration say that there's improved communication and care coordination, particularly between inpatient and outpatient settings, that it can facilitate systems approaches to quality improvement because of larger systems, and it can reduce duplicative testing and readmissions,” Kini said.","_key":"066d3422cb9b0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"6b56d48d853a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Critics of integration cite a fair amount of work that has shown that integration leads to increased prices, because of the ability of larger organizations to command higher prices, particularly from commercial insurers,” he said. “Reduced competition and reduced patient choice are also potential drawbacks of integration.”","_key":"3b6f24e64cc80"}],"_type":"block"},{"style":"normal","_key":"3a72cc0211be","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the analysis, Kini and coauthors followed cardiologists as consolidation picked up steam from 2008 to 2018. They could trace when physicians switched from using individual provider numbers to hospital tax ID numbers to bill Medicare. Based on each physician’s billing for Medicare fee-for-service patients, they tracked billing for hospitalization for incident heart failure (HF) and acute myocardial infarction (MI). Using a 3-year lookback period, the researchers excluded prior hospitalizations and examined mortality, readmission, and other quality and care utilization metrics.","_key":"9832b2a02f910"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The cardiologists studied were then split into 3 groups for a differences-in-differences analysis: nonintegrated, always integrated, or “switchers,” with the latter being those who changed from a nonhospital tax ID to a hospital tax ID for billing. These cardiologists were compared with the nonintegrated group for study period.","_key":"5669ff7918f90"}],"_type":"block","style":"normal","_key":"703333fb8d88"},{"children":[{"_type":"span","marks":[],"text":"According to the abstract, the sample covered 186,052 patients with acute (MI) and 259,849 HF patients treated by cardiologists who switched to integrated practice and 168,052 acute MI patients and 245,769 HF patients cared for by nonintegrated cardiologists.","_key":"c0d1325d030c0"}],"_type":"block","style":"normal","_key":"47b751cd18dc","markDefs":[]},{"_key":"4c3d32d2be44","markDefs":[],"children":[{"text":"“So, what did we find? 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The only significant difference was a small difference in the 30-day follow-up clinic visit; (adjusted difference: 1.04%; 95% CI: 0.46%-1.62%)."},{"_key":"a09ed1f6eddd","_type":"span","marks":["superscript"],"text":"2"},{"_type":"span","marks":[],"text":" Authors reported “no differences in utilization between patients treated by hospital-employed cardiologists (postswitch) vs independent cardiologists.”","_key":"ccd33e1e7632"}],"_type":"block","style":"normal","_key":"64a10dbfc717"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Giving the evidence that health care consolidation has contributed to rising costs,","_key":"7f7040938ed30"},{"_type":"span","marks":["em"],"text":" The American Journal of Managed Care","_key":"7f7040938ed31"},{"_type":"span","marks":[],"text":"® asked if the classic definition of value—quality divided by cost—meant vertical integration results in less value. 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This effort comes at a time of unprecedented inequity in the US, most directly in terms of income and wealth,” Perera said.","_key":"a01e55e553250","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"6249cf440c89","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, despite adoption of the Affordable Care Act in 2010, coverage gaps and the challenge of the underinsured remains.","_key":"7d6e270ce13a0"}]},{"children":[{"_type":"span","marks":[],"text":"Based on responses from 3544 adults with a mean age of 47.1 years (SD, 17.9 years), a majority of US adults agree that the rich have easier access to health care (79.5%; 95% CI, 75.7%-83.3%). Additional results showed:","_key":"39ab3e836f8d0"}],"_type":"block","style":"normal","_key":"f878ae8a2603","markDefs":[]},{"_type":"block","style":"normal","_key":"14f90a79133a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"More than half believe differential access based on income is unfair (56.5%; 52.0%-60.9%), with opinions varying significantly based on party affiliation; 70.8% of Democrats believe access to health care based on income is unfair, compared with 34.0% of Republicans.","_key":"462f3a3b3c310"}]},{"_type":"block","style":"normal","_key":"0d44a69aee91","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Only 10.7% of Americans (8.1%-13.3%) are willing to pay higher taxes to expand or improve the level of health care for all. Again, support splits by party affiliation, with 20.3% of Democrats supporting higher taxes vs 2.6% of Republicans. There was no statistically significant variation in responses based on age or income.","_key":"86195a2e7cb40"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The implications of these findings for cardiovascular health policy makers are challenging. Partisan dynamics, Perera said, “are more powerful than other demographic considerations when expanding health care coverage for cardiometabolic conditions, including preventive screening, guideline-directed therapies and in hospital care.”","_key":"f89910ba37540"}],"_type":"block","style":"normal","_key":"be983f5ca51d"},{"_key":"5078cf82a82e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Given challenges to vaccination, “alternative strategies such as supplementing income, increasing minimum wage, and addressing inflation” are in order, he said. “More globally, this work is just a reminder of the power of perceptions that people act not based on realities, but their perception of reality when making these big decisions, such as how to vote or how to seek care.”","_key":"3c89b116a2710"}],"_type":"block","style":"normal"},{"style":"normal","_key":"6b62621f4fae","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Total Spending on CV Care in US Could Reach $460 Billion by 2050","_key":"37e7b038b87d0"}],"_type":"block"},{"_key":"a1c7f50eea0b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"A forecast of the cost of cardiovascular (CV) care in the US presented during the poster session shows that spending could rise from the $324 billion spent in 2019 to $460 billion by 2050—a 41.9% increase over a 30-year period.","_key":"707a3f5747a10"},{"_type":"span","marks":["superscript"],"text":"4","_key":"3d94de30e563"}],"_type":"block","style":"normal"},{"imgcaption":[{"_type":"block","style":"normal","_key":"1c94b71eb909","markDefs":[],"children":[{"_key":"4e421eae9e50","_type":"span","marks":[],"text":"Feras Wahab, MS | Image credit: LinkedIn"}]}],"alignment":"left","_type":"figure","alt":"Feras Wahab, MS | Image credit: LinkedIn","_key":"bf3d022052dd","disableTextWrap":false,"widthP":25,"asset":{"_ref":"image-6ac2a488dd654b9e973bf13583fb66872bf461f5-233x273-jpg","_type":"reference"},"disableLightBox":true},{"_type":"block","style":"normal","_key":"da4b29114819","markDefs":[],"children":[{"marks":[],"text":"The forecast reflects an aging population and shifts due to the fallout of the COVID-19 pandemic, according to the analysts, from the Institute For Health Metrics and Evaluation (IHME) and the University of Washington, both in Seattle.","_key":"701f16ab39bf0","_type":"span"}]},{"style":"normal","_key":"e9d1ac04cb0e","markDefs":[],"children":[{"marks":[],"text":"The analysis, funded by the AHA and prepared by, was presented by Feras Wahab, MS, of IHME. “Cardiovascular care in the US has seen a dramatic increase in the last couple of years and decades,” he said. “The lack of detailed future cost forecasts poses a significant challenge to health care systems and policymakers who are unable to target the diseases or types of care that are most impacting the rising costs.”","_key":"8c3b56c1c36b0","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“So given all this, the objective for us was to estimate future US cardiovascular disease spending and utilization rates for 2020, to 2050, specified to the sex, state, disease, age and type of care level.”","_key":"f97893a4ec250"}],"_type":"block","style":"normal","_key":"4a48e5309dac"},{"style":"normal","_key":"3e3c9bc03ece","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Using IHME’s analysis of spending from 2000 to 2019 as a starting point, the analysts evaluated data from insurance claims, drug prescriptions, emergency department visits, inpatient stays, ambulatory care visits, nursing facility stays, and population forecasts from the Global Burden of Disease study.","_key":"0350032721370"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Results show the highest sources of increased spending will be from nursing facility care and home health care, which will rise form 11.8% to 13.9%, and from 7.1% to 8.2% of total spending, respectively. By 2050, spending for ischemic heart disease will be $110 billion up from $79 billion in 2019. Heart failure (HF) will follow at $102 billion, up from $64 billion in 2019.","_key":"3b1539808fda0"}],"_type":"block","style":"normal","_key":"7a834f7d05f1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"As a share of overall spending, HF is expected to increase from 19.7% of CV spending in 2019 to 22.1% in 2050. During this period, spending on obesity will rise from $13 billion to $15 billion, but obesity will shrink slightly (0.8%) as a share of all spending on CV spending, due to rising costs for other conditions.","_key":"132def04f5a60"}],"_type":"block","style":"normal","_key":"498b37b1d2d2"},{"children":[{"_type":"span","marks":[],"text":"Other results presented at the session showed detrimental effects of Medicaid work requirements on enrollment,","_key":"e80333bb7d910"},{"_key":"2a7fdf75b27c","_type":"span","marks":["superscript"],"text":"5"},{"_type":"span","marks":[],"text":" showed that publicly insured patients in Michigan had lower rates of cardiac rehabilitation utilization,","_key":"bdecdb5434ce"},{"_type":"span","marks":["superscript"],"text":"6","_key":"1c98f68a655c"},{"_type":"span","marks":[],"text":" and found that over a 20-year period ending in 2023, the American College of Cardiology (ACC) and the AHA spent $34.1 million and $14.3 million, respectively, on lobbying activity.","_key":"5252e865e1b1"},{"_type":"span","marks":["superscript"],"text":"7","_key":"a0cfdb3391b9"}],"_type":"block","style":"normal","_key":"aecc69314c26","markDefs":[]},{"style":"normal","_key":"078619c17228","markDefs":[],"children":[{"text":"The poster session was comoderated by Jay B. Lusk, MD, MBA, preventive medicine resident, University of North Carolina at Chapel Hill, and Paula Chatterjee, MD, MPH, director of Health Equity Research, Leonard Davis Institute of Health Economics and assistant professor of Medicine, Perelman School of Medicine, University of Pennsylvania.","_key":"29e74c8bce260","_type":"span","marks":[]}],"_type":"block"},{"_key":"d7df58007d0c","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"cf92812970f10"}],"_type":"block","style":"normal"},{"children":[{"text":"1. Moghtaderi A, Magid DJ, Masoudi FA, et al. The association of hospital-cardiologist integration with patient outcomes, care quality, and utilization. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois; Abstract MDP1544.","_key":"a10afd0b27860","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"503858ed0864","markDefs":[]},{"_type":"block","style":"normal","_key":"c20ba2bb61b1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"2. Moghtaderi A, Magid DJ, Yuan AY, Black B, Luo QE, Kini V. The association of hospital-cardiologist integration with patient outcomes, care quality, and utilization. ","_key":"6168c90bf5860"},{"text":"J Am Coll Cardiol.","_key":"6168c90bf5861","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" Published online November 15, 2024. doi:10.1016/j.jacc.2024.10.109","_key":"6168c90bf5862"}]},{"_type":"block","style":"normal","_key":"761aadb3701c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"3. Perera S, Wadhera RK, Khullar D. Americans’ views on healthcare coverage, access, and equity in the US: implications for cardiovascular health. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois; Abstract MDP1540.","_key":"4ebcb6eb20ac0"}]},{"children":[{"_type":"span","marks":[],"text":"4. Wahab F, Lindstrom M, Roth GA, Dieleman J. Forecasting US state-level health expenditures for cardiovascular diseases through 2050. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois; Abstract MDP 1541.","_key":"a10b00acefe30"}],"_type":"block","style":"normal","_key":"89d47085567a","markDefs":[]},{"markDefs":[],"children":[{"_key":"b9513c833f0f0","_type":"span","marks":[],"text":"5. Engel-Rebitzer E, Marinacci L, Zheng Z, et al. Medicaid work requirements and changes in insurance coverage, employment, access to care, and health status overall and among people with cardiovascular disease. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois. Abstract MDP1542."}],"_type":"block","style":"normal","_key":"f7d7b6b71818"},{"children":[{"_type":"span","marks":[],"text":"6. Pedamallu H, Mantey J, Sukul D, et al. Publicly-insured patients have lower rates of cardiac rehabilitation enrollment: a statewide experience in Michigan. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois. Abstract MDP1543.","_key":"6ebe1d5644980"}],"_type":"block","style":"normal","_key":"b1e9368f277a","markDefs":[]},{"_key":"402341cddf46","markDefs":[],"children":[{"_type":"span","marks":[],"text":"7. Patel PN, Milks MW, Miller AP, Mehta LS. Advocacy in cardiology: healthcare lobbying and campaign finance activities of major cardiovascular professional societies, 2003 to 2023. Presented at: 2024 American Heart Association Scientific Sessions, November 16-18, 2024; Chicago, Illinois. 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Yet, early data from the 2024 to 2025 respiratory virus season show concerningly low vaccination rates across the country, according to a study published in the CDC’s ","_key":"29a4f763d9e04","_type":"span"},{"_type":"span","marks":["em","0b1e150b543a"],"text":"Morbidity and Mortality Weekly Report","_key":"29a4f763d9e05"},{"_type":"span","marks":[],"text":".","_key":"29a4f763d9e06"},{"marks":["superscript"],"text":"1","_key":"0e5d43636777","_type":"span"}],"_type":"block","style":"normal","_key":"3f0b704dad4b","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/rsv","_key":"172a9ca37d13"},{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/covid-19","_key":"a18e78bff152"},{"nofollow":true,"blank":true,"_type":"link","href":"https://www.cdc.gov/mmwr/volumes/73/wr/mm7346a2.htm?s_cid=mm7346a2_w#suggestedcitation","_key":"0b1e150b543a"}]},{"_type":"figure","widthP":35,"disableLightBox":true,"alt":"Nursing home care | Image credit: Kzenon - stock.adobe.com","imgcaption":[{"markDefs":[],"children":[{"marks":["aligncenter"],"text":"Findings underscore the urgent need to boost vaccination efforts to safeguard one of the most vulnerable populations from preventable respiratory illnesses. | Image credit: Kzenon - stock.adobe.com","_key":"fc1135718d360","_type":"span"}],"_type":"block","style":"normal","_key":"f7080a022f4d"}],"_key":"b57b5285ea9e","alignment":"left","asset":{"_ref":"image-316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840-jpg","_type":"reference"},"disableTextWrap":false},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Most nursing home residents have not been afforded the protection offered by vaccination against severe COVID-19, influenza, and RSV disease during the 2024–2025 respiratory virus season,” wrote the investigators of the report. “Addressing low coverage of vaccination against COVID-19, influenza, and RSV must be prioritized, and larger facilities and those in counties with high social vulnerability could benefit from effective interventions.”","_key":"961b4560b1e60"}],"_type":"block","style":"normal","_key":"37782ba74549"},{"_key":"201f2818d226","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5c0d97a7c5b00"}],"_type":"block","style":"normal"},{"style":"normal","_key":"160d1fa93f68","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Current CDC guidelines recommend a single dose of the RSV vaccine for all adults aged 75 years and older, and adults aged 60 to 74 years at increased risk for severe RSV.","_key":"8fbe3635fb430"},{"_type":"span","marks":["superscript"],"text":"2","_key":"fe850fe3e887"}],"_type":"block"},{"children":[{"_key":"d58d8d64b6720","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"c5afdbe65bf6","markDefs":[]},{"_key":"a54a651555f3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"To evaluate vaccination coverage among nursing home residents, data were collected from CMS-certified nursing homes reporting to the CDC’s National Healthcare Safety Network (NHSN) during the week of November 10, 2024.","_key":"92a1143910a40"},{"_type":"span","marks":["superscript"],"text":"1 ","_key":"3483f0446c9c"},{"_type":"span","marks":[],"text":"Facilities electronically reported the number of residents who occupied a bed for at least 1 day during the collection week and the number vaccinated with the 2024 to 2025 COVID-19 vaccine, influenza vaccine, and RSV vaccine. Influenza and RSV vaccination data were reported voluntarily, while COVID-19 vaccination reporting was mandatory.","_key":"6aa20a28c07f"}],"_type":"block","style":"normal"},{"_key":"242200872a9c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\nVaccination coverage among nursing home residents was reported by 51.8% of facilities, with only 17.9% of residents receiving the vaccine. Coverage varied widely by region, from 9.3% in HHS Region 6 to 29.2% in HHS Region 8, and was highest in counties with lower social vulnerability (21.3%) and in smaller facilities (24.1%).","_key":"6aa9a95312e70"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a3b4712b0f6f0"}],"_type":"block","style":"normal","_key":"4f23d31519ae"},{"_key":"655c13299ace","markDefs":[],"children":[{"_key":"6d6e2e1e43230","_type":"span","marks":[],"text":"Influenza vaccination coverage was voluntarily reported by 59.4% of facilities, with 58.4% of residents vaccinated. Coverage ranged from 50.9% in HHS Region 10 to 64.1% in HHS Region 1 and was higher in the least socially vulnerable counties (60.8%) and smaller facilities (62.9%)."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"9b05c96fb9c70","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"ef79beabf256"},{"children":[{"marks":[],"text":"COVID-19 vaccination coverage, which was reported by 92.9% of facilities, remained low, with only 29.7% of residents receiving the 2024 to 2025 COVID-19 vaccine. Coverage was lowest in HHS Region 6 (19.8%) and highest in Region 8 (38.6%), with better rates observed in smaller facilities (34.7%) and less vulnerable counties (33.6%). These findings highlight substantial gaps in vaccine uptake, particularly for RSV and COVID-19.","_key":"2e9941b21abf0","_type":"span"}],"_type":"block","style":"normal","_key":"e026ae7211c9","markDefs":[]},{"_type":"block","style":"normal","_key":"54cc79d7a6ea","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b61eb94f9e580"}]},{"_key":"c7463e245961","markDefs":[],"children":[{"marks":[],"text":"However, the investigators noted some limitations. First, reporting of influenza and RSV vaccination coverage was voluntary, and facilities that chose to report may have had higher vaccination rates than those that did not, potentially biasing the results. Second, the increase in the number of facilities reporting influenza and RSV vaccination coverage compared with the previous season limited direct comparisons between seasons. Third, RSV vaccination coverage was calculated for residents of all ages, although approximately 91% of nursing home residents are aged 60 years and older, for whom the vaccine is recommended. Finally, vaccination data were aggregated, preventing assessment of individual-level factors influencing vaccine uptake, such as demographic or clinical characteristics.","_key":"a0321c48d9f60","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"8a018cb91a740"}],"_type":"block","style":"normal","_key":"e2063803964a","markDefs":[]},{"style":"normal","_key":"dc1de8833529","markDefs":[],"children":[{"text":"Despite these limitations, these findings underscore the urgent need to boost vaccination efforts to safeguard one of the most vulnerable populations from preventable respiratory illnesses.","_key":"2435609055e90","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4b5169f9282e0"}],"_type":"block","style":"normal","_key":"b158846d9f4c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Although CDC and other federal agencies have programs in place to address both the financial and vaccine hesitancy–related barriers to vaccination in nursing homes, more needs to be done at every level to protect nursing home residents, who constitute one of the population groups at highest risk for severe respiratory disease,” wrote the investigators.","_key":"499c0bfb4d2d0"}],"_type":"block","style":"normal","_key":"4c732e0da54e"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c5e804155d1a0"}],"_type":"block","style":"normal","_key":"c10bc8ecf31f"},{"_key":"9aaf3d9a68fb","markDefs":[],"children":[{"marks":["strong"],"text":"References","_key":"ef3b9dcea98d0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[{"_type":"link","href":"http://dx.doi.org/10.15585/mmwr.mm7346a2","_key":"0b631d436eed","nofollow":true,"blank":true}],"children":[{"marks":[],"text":"1. Reses HE, Segovia G, Dubendris H, et al. Coverage with influenza, respiratory syncytial virus, and COVID-19 vaccines among nursing home residents — National Healthcare Safety Network, United States, November 2024. ","_key":"7b8f957b8f2e0","_type":"span"},{"text":"MMWR Morb Mortal Wkly Rep.","_key":"7b8f957b8f2e1","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" 2024;73:1052-1057. doi:","_key":"7b8f957b8f2e2"},{"_type":"span","marks":["0b631d436eed"],"text":"http://dx.doi.org/10.15585/mmwr.mm7346a2","_key":"7b8f957b8f2e3"}],"_type":"block","style":"normal","_key":"8735f3f6f08a"},{"style":"normal","_key":"20ab0a0618e5","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.html","_key":"025b5ce4476d"}],"children":[{"_key":"194262328b8a0","_type":"span","marks":[],"text":"2. RSV vaccine guidance for older adults. CDC. August 30, 2024. Accessed November 22, 2024. "},{"_type":"span","marks":["025b5ce4476d"],"text":"https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.html","_key":"194262328b8a1"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"572013791b050"}],"_type":"block","style":"normal","_key":"d83158e2a1a2"}],"contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles"},"gptTakeaways":"• Nursing home residents face high risks from respiratory viruses, yet vaccination rates for RSV, influenza, and COVID-19 are low for the 2024–2025 season.\n\n• Only 17.9% of residents received the RSV vaccine, 58.4% received the influenza vaccine, and 29.7% received the COVID-19 vaccine, with regional variations.\n\n• Vaccination coverage is higher in smaller facilities and less socially vulnerable counties, highlighting disparities in vaccine uptake.\n\n• Limitations include voluntary reporting for influenza and RSV vaccines, potential reporting bias, and aggregated data preventing individual-level analysis.\n\n• Despite existing programs, more efforts are needed to address barriers and improve vaccination rates among nursing home residents.","factCheckAuthors":null,"title":"Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake ","is_visible":true,"_rev":"EbkpNMUbiIwDU1ASlr9zxQ","authors":[{"displayName":"Pearl Steinzor","url":"pearl-steinzor"}],"gptSummary":"Nursing home residents are at increased risk for severe complications from respiratory viruses, yet vaccination rates for RSV, influenza, and COVID-19 remain low for the 2024–2025 season. 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