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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F3649ad13aafe34adccd0aa13a3cc794c8fb7be00-1280x721.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">August 31st 2024</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/using-active-surveillance-to-spare-men-from-unneeded-prostate-cancer-treatment">Using Active Surveillance to Spare Men From Unneeded Prostate Cancer Treatment</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/laura-joszt"><i>Laura Joszt, MA</i></a></span></div></div><a href="/view/using-active-surveillance-to-spare-men-from-unneeded-prostate-cancer-treatment"><a href="/view/using-active-surveillance-to-spare-men-from-unneeded-prostate-cancer-treatment"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Advances in technology have made active surveillance in men with prostate cancer possible and prevented treatment for men who don’t need it, said Matthew Nielsen, MD, FACS, chair, Department of Urology, University of North Carolina School of Medicine.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/dr-jun-gong-improved-access-closes-the-gaps-between-black-white-men-with-prostate-cancer"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span 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hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/expert-panel-addresses-prostate-cancer-misconceptions-importance-of-screening"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2322e0ad26bf002facd05bf5bd7ecc1c6091ef0a-419x279.jpg?fit=crop&auto=format" alt="Patient and Clinician" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 14th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/expert-panel-addresses-prostate-cancer-misconceptions-importance-of-screening">Expert Panel Addresses Prostate Cancer Misconceptions, Importance of Screening</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/expert-panel-addresses-prostate-cancer-misconceptions-importance-of-screening"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Panelists from the American College of Surgeons (ACS) and the American Urological Association spread awareness about the realities of prostate cancer, the importance of screening, and ways for men to approach their health concerns and prevention. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/adaptive-sbrt-may-reduce-gu-gi-toxicity-risk-in-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9911fa277cdb7e885f921bc6d716d824b572eeea-250x249.jpg?fit=crop&auto=format" alt="Prostate cancer | Image credit: freshidea - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 8th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/adaptive-sbrt-may-reduce-gu-gi-toxicity-risk-in-prostate-cancer">Adaptive SBRT May Reduce GU/GI Toxicity Risk in Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/russ-conroy">Russ Conroy</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/adaptive-sbrt-may-reduce-gu-gi-toxicity-risk-in-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A meta-analysis found that the use of magnetic resonance–guided daily adaptive stereotactic body radiotherapy (SBRT) correlated with fewer acute grade 2 or higher gastrointestinal (GI) or genitourinary (GU) toxicities compared with CT-guided non-adaptive SBRT in patients with prostate cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/genetic-alterations-discovered-in-hispanic-men-with-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0da7423757eb9df8a7bfaf897236692c68ee0e91-800x400.jpg?fit=crop&auto=format" alt="Double Helix purple" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 6th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/genetic-alterations-discovered-in-hispanic-men-with-prostate-cancer">Genetic Alterations Discovered in Hispanic Men With Prostate Cancer </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/genetic-alterations-discovered-in-hispanic-men-with-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In an exploratory analysis, Hispanic men with primary and metastatic prostate cancer exhibited higher frequencies of certain altered genes compared to non-Hispanic men. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/while-prognostic-bcr-may-not-be-a-strong-surrogate-end-point-for-prostate-cancer-survival"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4f00a3a39a8550aae42530e2d7769a9d0cc2759a-888x456.jpg?fit=crop&auto=format" alt="While Prognostic, BCR May Not Be a Strong Surrogate End Point for Prostate Cancer Survival" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 31st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/while-prognostic-bcr-may-not-be-a-strong-surrogate-end-point-for-prostate-cancer-survival">While Prognostic, BCR May Not Be a Strong Surrogate End Point for Prostate Cancer Survival</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/while-prognostic-bcr-may-not-be-a-strong-surrogate-end-point-for-prostate-cancer-survival"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Measuring biochemical recurrence (BCR) as a surrogate marker produces unreliable results as a primary end point for overall survival of patients with localized prostate cancer, a study found. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mri-screening-provides-advantages-for-detecting-clinically-significant-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/54505e4bdfb53a5b762997563560f2f2708ee008-1280x800.jpg?fit=crop&auto=format" alt="MRI Screening Provides Advantages for Detecting Clinically Significant Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 25th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mri-screening-provides-advantages-for-detecting-clinically-significant-prostate-cancer">MRI Screening Provides Advantages for Detecting Clinically Significant Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mri-screening-provides-advantages-for-detecting-clinically-significant-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">MRI screening shows promise for predicting clinically significant prostate cancer (PCa) early on and independently of prostate-specific antigen (PSA) assessment. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/foundationone-cdx-fda-approved-for-niraparib-abiraterone-in-brca-positive-mcrpc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef8b0a7b39c2dabf59b8810287d35e8e94aaa8da-480x339.jpg?fit=crop&auto=format" alt="FDA Approved" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 19th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/foundationone-cdx-fda-approved-for-niraparib-abiraterone-in-brca-positive-mcrpc">FDA Approves FoundationOne CDx as Companion Diagnostic for Niraparib/Abiraterone in mCRPC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/russ-conroy">Russ Conroy</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/foundationone-cdx-fda-approved-for-niraparib-abiraterone-in-brca-positive-mcrpc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA companion diagnostic designation for FoundationOne CDx may improve access to niraparib/abiraterone acetate for eligible patients with metastatic castration-resistant prostate cancer (mCRPC) harboring a BRCA mutation.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-validates-psa-based-recurrence-definitions-for-prostate-cancer-prognostication"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Doctor and Patient Discussing Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 19th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-validates-psa-based-recurrence-definitions-for-prostate-cancer-prognostication">Study Validates PSA-Based Recurrence Definitions for Prostate Cancer Prognostication</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-validates-psa-based-recurrence-definitions-for-prostate-cancer-prognostication"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers determined that the Huber et al. criteria regarding prostate-specific antigen (PSA) levels may more accurately predict the need for additional treatment or the possibility of treatment failure compared with other PSA-based definitions.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-add-flotufolastat-f-18-injection-for-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Flotufolastat F 18 Injection for Prostate Cancer Added to NCCN Guidelines" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 12th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-add-flotufolastat-f-18-injection-for-prostate-cancer">Flotufolastat F 18 Injection for Prostate Cancer Added to NCCN Guidelines</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-add-flotufolastat-f-18-injection-for-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Data from 2 studies, LIGHTHOUSE and SPOTLIGHT, have shown the benefit of flotufolastat F 18 injection as a radiohybrid PSMA-targeted PET imaging agent in prostate cancer. The agent has now been added to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/novel-biomarker-panel-accurately-predicts-prostate-cancer-outcomes"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9911fa277cdb7e885f921bc6d716d824b572eeea-250x249.jpg?fit=crop&auto=format" alt="Prostate Cancer Detection" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 11th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/novel-biomarker-panel-accurately-predicts-prostate-cancer-outcomes">Novel Biomarker Panel Accurately Predicts Prostate Cancer Outcomes</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/novel-biomarker-panel-accurately-predicts-prostate-cancer-outcomes"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New biomarker technology shows promising results for predicting the prognosis of patients with prostate cancer after radical prostatectomy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-model-may-define-margins-and-help-identify-risk-in-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5053f8afd729a7b9632e37b0af08a140131bf0f5-1200x681.jpg?fit=crop&auto=format" alt="AI graphic" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 5th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-model-may-define-margins-and-help-identify-risk-in-prostate-cancer">AI Model May Define Margins and Help Identify Risk in Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/nicholas-wrigley">Nicholas Wrigley</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-model-may-define-margins-and-help-identify-risk-in-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Investigators of a retrospective study report that an AI deep learning model may also predict negative margin probabilities better than conventional modalities.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/equitable-care-access-may-reduce-outcome-disparities-in-advanced-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4925efa112adde4596b246b2593fe2120993a456-6483x3871.jpg?fit=crop&auto=format" alt="Image of paper figures representing skin tones" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/equitable-care-access-may-reduce-outcome-disparities-in-advanced-prostate-cancer">Equitable Care Access May Reduce Outcome Disparities in Advanced Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/equitable-care-access-may-reduce-outcome-disparities-in-advanced-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A recent study suggests that a lack of equitable access to care contributes to known disparities in outcomes between Black and White patients with advanced prostate cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-baseline-uric-acid-levels-and-prostate-cancer-prognosis"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Consultation with doctor for prostate cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 31st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-baseline-uric-acid-levels-and-prostate-cancer-prognosis">Study Finds Link Between Baseline Uric Acid Levels and Prostate Cancer Prognosis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-baseline-uric-acid-levels-and-prostate-cancer-prognosis"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers linking uric acid (UA) levels to the aggressiveness and progression of prostate cancer believe these findings can be used to study UA influence on prostate cancer–related mortality risk. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/prostate-specific-antigens-post-salvage-radiotherapy-predict-survival-outcomes-of-patients-with-recurrent-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Doctor and man discussing prostate" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 26th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/prostate-specific-antigens-post-salvage-radiotherapy-predict-survival-outcomes-of-patients-with-recurrent-prostate-cancer">Prostate-Specific Antigens Post Salvage Radiotherapy Predict Survival Outcomes of Patients With Recurrent Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/prostate-specific-antigens-post-salvage-radiotherapy-predict-survival-outcomes-of-patients-with-recurrent-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Following prostatectomy in patients with recurrent prostate cancer, researchers analyzed post–salvage radiotherapy prostate-specific antigen (PSA) values and the percentages of PSA decline to anticipate patient survival rates. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/localized-therapy-improves-prognosis-in-some-men-with-metastatic-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f990f0c4565290c49d2e7a879600afa42f9befd6-1000x667.jpg?fit=crop&auto=format" alt="Older White patient speaking with Black doctor" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 22nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/localized-therapy-improves-prognosis-in-some-men-with-metastatic-prostate-cancer">Localized Therapy Improves Prognosis in Some Men With Metastatic Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/localized-therapy-improves-prognosis-in-some-men-with-metastatic-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Forms of localized treatment have potential to positively impact the survival rate and prognosis of men diagnosed with certain forms of metastatic prostate cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-examines-telehealth-use-disparities-among-prostate-cancer-survivors"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/06c2ad532c4bd620b1284b03ef46d257ea32475e-1000x564.jpg?fit=crop&auto=format" alt="Cell Phone With Telehealth App" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 19th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-examines-telehealth-use-disparities-among-prostate-cancer-survivors">Study Examines Telehealth Use Disparities Among Prostate Cancer Survivors</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-examines-telehealth-use-disparities-among-prostate-cancer-survivors"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Most prostate cancer survivors surveyed reported feeling that telehealth cannot fully replace in-person visits, with perceptions varying significantly based on education level.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/olaparib-increases-radioligand-activity-in-mcrpc-early-results-suggest"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9911fa277cdb7e885f921bc6d716d824b572eeea-250x249.jpg?fit=crop&auto=format" alt="Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 14th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/olaparib-increases-radioligand-activity-in-mcrpc-early-results-suggest">Olaparib Increases Radioligand Activity in mCRPC, Early Findings Suggest </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brittany-lovely">Brittany Lovely</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/olaparib-increases-radioligand-activity-in-mcrpc-early-results-suggest"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Enhanced antitumor activity was seen with the addition of the PARP inhibitor olaparib to the radioligand lutetium Lu 177 vipivotide tetraxetan in patients with metastatic castration-resistant prostate cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/many-patients-with-prostate-cancer-may-face-treatment-related-financial-toxicity"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/516f844032d6644077e7e4c519b754ac154bd887-1280x800.jpg?fit=crop&auto=format" alt="Man in Hospital Bed" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 12th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/many-patients-with-prostate-cancer-may-face-treatment-related-financial-toxicity">Many Patients With Prostate Cancer May Face Treatment-Related Financial Toxicity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/many-patients-with-prostate-cancer-may-face-treatment-related-financial-toxicity"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with metastatic prostate cancer who face high financial toxicity resulting from treatment may cope in ways that impact overall quality of life, according to a recent study. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/novel-ai-model-predicts-adt-benefit-in-patients-with-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/83522c0094be7147a1b83bfffd6acb0ba7bfe65c-4174x2959.jpg?fit=crop&auto=format" alt="Artificial intelligence model graphic" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 6th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/novel-ai-model-predicts-adt-benefit-in-patients-with-prostate-cancer">Novel AI Model Predicts ADT Benefit in Patients With Prostate Cancer </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/novel-ai-model-predicts-adt-benefit-in-patients-with-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A predictive artificial intelligence (AI) biomarker of androgen deprivation therapy (ADT) benefit in prostate cancer was validated in a recent study published in NEJM Evidence.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-cardiorespiratory-fitness-impacts-cancer-risk-in-men"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/85892c69e9479c2573c6d55d559395be72c00bc7-4546x2856.jpg?fit=crop&auto=format" alt="Study Suggests Cardiorespiratory Fitness Impacts Cancer Risk in Men" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 30th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-cardiorespiratory-fitness-impacts-cancer-risk-in-men">Study Suggests Cardiorespiratory Fitness Impacts Cancer Risk in Men</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-suggests-cardiorespiratory-fitness-impacts-cancer-risk-in-men"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The study aimed to assess whether CRF was associated with prostate, colon, and lung cancer incidence and mortality among men in Sweden.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-talazoparib-plus-enzalutamide-for-mcrpc-with-hrr-gene-mutations"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/407d27c5fd74836a18293620e5dbacab64d631cd-2000x2000.jpg?fit=crop&auto=format" alt="FDA Approves Talazoparib Plus Enzalutamide for mCRPC With HRR Gene Mutations " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 21st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-talazoparib-plus-enzalutamide-for-mcrpc-with-hrr-gene-mutations">FDA Approves Talazoparib Plus Enzalutamide for mCRPC With HRR Gene Mutations </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-talazoparib-plus-enzalutamide-for-mcrpc-with-hrr-gene-mutations"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Talazoparib in combination with enzalutamide showed a 55% reduction in the risk of disease progression or death for patients with metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination repair (HRR) gene mutations in the phase 3 TALAPRO-2 trial.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/imrt-for-prostate-cancer-not-associated-with-increased-risk-of-second-primary-cancers-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="IMRT for Prostate Cancer Not Associated With Increased Risk of Second Primary Cancers, Study Finds " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 16th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/imrt-for-prostate-cancer-not-associated-with-increased-risk-of-second-primary-cancers-study-finds">IMRT for Prostate Cancer Not Associated With Increased Risk of Second Primary Cancers, Study Finds </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/imrt-for-prostate-cancer-not-associated-with-increased-risk-of-second-primary-cancers-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">There was no difference in second primary cancer risk among older adult male patients treated with intensity-modulated radiotherapy (IMRT) vs 3-dimensional conformal radiation therapy for prostate cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-brca-mutated-mcrpc-show-worse-outcomes-vs-non-brca-hrr-mcrpc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Patients With BRCA-Mutated mCRPC Show Worse Outcomes vs Non-BRCA HRR mCRPC" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 10th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-brca-mutated-mcrpc-show-worse-outcomes-vs-non-brca-hrr-mcrpc">Patients With BRCA-Mutated mCRPC Show Worse Outcomes vs Non-BRCA HRR mCRPC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jonah-feldman">Jonah Feldman</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-brca-mutated-mcrpc-show-worse-outcomes-vs-non-brca-hrr-mcrpc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An analysis of patients with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) deficiency mutations showed that patients with BRCA mutations had poor outcomes compared with those without BRCA mutations and those with non-BRCA HRR mutations.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-finds-psma-pet-may-hold-prognostic-utility-in-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9911fa277cdb7e885f921bc6d716d824b572eeea-250x249.jpg?fit=crop&auto=format" alt="Study Finds PSMA-PET May Hold Prognostic Utility in Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 9th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-psma-pet-may-hold-prognostic-utility-in-prostate-cancer">Study Finds PSMA-PET May Hold Prognostic Utility in Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-psma-pet-may-hold-prognostic-utility-in-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Research presented at the American Society of Clinical Oncology Annual Meeting found prostate-specific membrane antigen ligand positron emission tomography (PSMA-PET) to be associated with worse overall survival in prostate cancer without distant metastasis based on conventional imaging. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-first-radiohybrid-psma-targeted-pet-imaging-agent-for-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/407d27c5fd74836a18293620e5dbacab64d631cd-2000x2000.jpg?fit=crop&auto=format" alt="FDA Approves First Radiohybrid PSMA-Targeted PET Imaging Agent for Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 2nd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-first-radiohybrid-psma-targeted-pet-imaging-agent-for-prostate-cancer">FDA Approves First Radiohybrid PSMA-Targeted PET Imaging Agent for Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kristi-rosa">Kristi Rosa</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-first-radiohybrid-psma-targeted-pet-imaging-agent-for-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA has approved flotufolastat F 18 injection for positron emission tomography of prostate-specific membrane antigen–positive lesions in certain men with prostate cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-olaparib-combination-to-treat-brca-mutated-metastatic-castration-resistant-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2748d86e23cc026ac47dd5987bd1320c71de80e4-1366x768.jpg?fit=crop&auto=format" alt="FDA Approves Olaparib Combination to Treat BRCA-Mutated Metastatic Castration-Resistant Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 1st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-olaparib-combination-to-treat-brca-mutated-metastatic-castration-resistant-prostate-cancer">FDA Approves Olaparib Combination to Treat BRCA-Mutated Metastatic Castration-Resistant Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-olaparib-combination-to-treat-brca-mutated-metastatic-castration-resistant-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Olaparib plus abiraterone and prednisone or prednisolone already is approved in the European Union and several other countries.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-identifies-predictors-of-psa-screening-for-men-in-florida"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8d3be7eff398800fbcc0d1ce2d05eb3971b1b814-849x565.jpg?fit=crop&auto=format" alt="map of florida" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 24th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-identifies-predictors-of-psa-screening-for-men-in-florida">Study Identifies Predictors of PSA Screening for Men in Florida</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gianna-melillo">Gianna Melillo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-identifies-predictors-of-psa-screening-for-men-in-florida"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Results are based off of data from the Florida Behavioral Risk Factor Surveillance System. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-ses-linked-with-lower-overall-survival-in-early-onset-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/af3141c7ff76a76822e694787bda03a4b75b60d1-1280x640.jpg?fit=crop&auto=format" alt="Bladder and prostate in the doctor's hand, HTA. Prostate cancer, bladder cancer, men's health care. Modern digital medicine in urology: © Tom - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 16th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-ses-linked-with-lower-overall-survival-in-early-onset-prostate-cancer">Low SES Linked With Lower Overall Survival in Early-Onset Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gianna-melillo">Gianna Melillo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-ses-linked-with-lower-overall-survival-in-early-onset-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers suggest socioeconomic status (SES) be considered in prognostic algorithms going forward. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/extended-plnd-marginally-reduces-recurrence-risk-in-high-risk-patients-undergoing-radical-prostatectomy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7dd74cda7bcc60930d6a2db561fc4ba4bda45820-1280x770.jpg?fit=crop&auto=format" alt="Paper with prostate cancer and light blue ribbon: © Vitalii Vodolazskyi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 9th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/extended-plnd-marginally-reduces-recurrence-risk-in-high-risk-patients-undergoing-radical-prostatectomy">Extended PLND Marginally Reduces Recurrence Risk in High-Risk Patients Undergoing Radical Prostatectomy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/extended-plnd-marginally-reduces-recurrence-risk-in-high-risk-patients-undergoing-radical-prostatectomy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">No benefit was found in low-risk patients who underwent pelvic lymph node dissection (PLND).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/certain-comorbidities-may-predict-cardiovascular-event-risk-after-adt-for-prostate-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e954d79bcf7270333f5e42ee4a19cbcc07c52262-1200x665.jpg?fit=crop&auto=format" alt="Certain Comorbidities May Predict Cardiovascular Event Risk After ADT for Prostate Cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 5th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/certain-comorbidities-may-predict-cardiovascular-event-risk-after-adt-for-prostate-cancer">Certain Comorbidities May Predict Cardiovascular Event Risk After ADT for Prostate Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/certain-comorbidities-may-predict-cardiovascular-event-risk-after-adt-for-prostate-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The presence of certain comorbidities prior to androgen deprivation therapy (ADT) for prostate cancer may be associated with a greater risk of cardiovascular events after starting ADT, recent research found. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-prostate-cancer-most-concerned-with-adt-cost-delivery-method"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800.jpg?fit=crop&auto=format" alt="Doctor and Patient Talking" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 4th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-prostate-cancer-most-concerned-with-adt-cost-delivery-method">Patients With Prostate Cancer Most Concerned With ADT Cost, Delivery Method </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-prostate-cancer-most-concerned-with-adt-cost-delivery-method"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A cross-sectional survey of patient preferences found that the out-of-pocket cost of treatment was the most impactful attribute for patients when choosing an androgen deprivation therapy (ADTs) for their prostate cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/prostate-cancer?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/prostate-cancer?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/prostate-cancer?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/prostate-cancer?page=4">4</a><a class="px-4 py-2 border-y border-r" href="/compendium/prostate-cancer?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span 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","contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"authors":[{"displayName":"Kyle Munz","url":"kyle-munz"}],"factCheckAuthors":null,"_id":"2bf1101f-9751-4f4c-baa5-0501d2f59555","title":"Equitable Care Access May Reduce Outcome Disparities in Advanced Prostate Cancer","thumbnail":{"_type":"mainImage","alt":"Image of paper figures representing skin tones","asset":{"_ref":"image-4925efa112adde4596b246b2593fe2120993a456-6483x3871-jpg","_type":"reference"}},"published":"2023-08-03T13:00:00.000Z","updatedOn":null},{"thumbnail":{"alt":"Consultation with doctor for prostate cancer","asset":{"_ref":"image-3f7f99efed72bfd1ce6398367251fe1358aa1fde-1200x800-jpg","_type":"reference"},"_type":"mainImage"},"contentCategory":{"name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory"},"factCheckAuthors":null,"_id":"0e654453-7eca-41a7-a74f-5fa5782dbbd4","title":"Study Finds Link Between Baseline Uric Acid Levels and Prostate Cancer Prognosis","url":"study-finds-link-between-baseline-uric-acid-levels-and-prostate-cancer-prognosis","authors":[{"displayName":"Kyle Munz","url":"kyle-munz"}],"summary":"Researchers linking uric acid (UA) levels to the aggressiveness and progression of prostate cancer believe these findings can be used to study UA influence on prostate cancer–related mortality risk. 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","title":"Many Patients With Prostate Cancer May Face Treatment-Related Financial Toxicity","published":"2023-07-12T18:40:31.926Z","updatedOn":null,"contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"authors":[{"displayName":"Rose McNulty","url":"rose-mcnulty"}],"factCheckAuthors":null,"_id":"0760335f-ab42-497b-b2c5-783bc220711d"},{"title":"Novel AI Model Predicts ADT Benefit in Patients With Prostate Cancer ","url":"novel-ai-model-predicts-adt-benefit-in-patients-with-prostate-cancer","thumbnail":{"_type":"mainImage","alt":"Artificial intelligence model 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showed a 55% reduction in the risk of disease progression or death for patients with metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination repair (HRR) gene mutations in the phase 3 TALAPRO-2 trial.","published":"2023-06-21T17:11:20.222Z","updatedOn":null,"contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"title":"FDA Approves Talazoparib Plus Enzalutamide for mCRPC With HRR Gene Mutations ","thumbnail":{"_type":"mainImage","asset":{"_ref":"image-407d27c5fd74836a18293620e5dbacab64d631cd-2000x2000-jpg","_type":"reference"}}},{"updatedOn":null,"contentCategory":{"name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory"},"authors":[{"displayName":"Rose 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Shore, MD, FACS, medical director of the Carolina Urologic Research Center. In PEACE-1, patients received abiraterone acetate with prednisone plus docetaxel, and in ARASENS, patients received darolutamide with docetaxel.","_key":"58b9d658a2b90","_type":"span"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"35114863912d"}],"_type":"block","style":"normal","_key":"9cbf444d5acc"},{"children":[{"_type":"span","marks":[],"text":"The addition of docetaxel means a multidisciplinary team is important, he added. Many urologists won’t give docetaxel and will send the patient to a medical oncologist. 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From a support services perspective, there's a role to expand a lot of services. Some of these were described in the Oncology Care Model such as social work or nutritional support or navigation, physical therapy, palliative care; these are things that are not traditionally reimbursed in a fee-for-service environment, however, can lead to improved outcomes for patients or reduced costs throughout the patient journey. 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","_key":"4b40f18e2d1c"}],"_type":"block","style":"normal","_key":"b3ac8892465d","markDefs":[]},{"style":"normal","_key":"537743df4045","markDefs":[],"children":[{"text":"","_key":"3245214fe7f4","_type":"span","marks":[]}],"_type":"block"},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"8d864fb0f3ee"}],"_type":"block","style":"normal","_key":"9433c674e40f","markDefs":[]},{"children":[{"_type":"span","marks":["strong"],"text":"Is payer coverage for genomic testing keeping pace with the precision oncology options in genitourinary disease?","_key":"1621841abbe00"}],"_type":"block","style":"normal","_key":"83bb9d75ad3a","markDefs":[]},{"style":"normal","_key":"c75bbca30860","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I'm fortunate enough to be able to send next-generation sequencing on virtually all of my patients with metastatic disease. And I routinely send both tissue-based as well as liquid cell-free DNA next-generation sequencing for all patients with metastatic GU [genitourinary] cancers.","_key":"45be012e67da0"}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"6da86e4e0576","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"1c72c7c2a85a"},{"_key":"a106b60638c7","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"The most recent annual report on cancer statistics from the American Cancer Society showed a rise in prostate cancer after years of decline. What are your thoughts on why prostate cancer is increasing?","_key":"64e8d749c3550"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"There's recently been an increase in the incidence of prostate cancer diagnoses as well as a trend toward later-stage diagnoses, which a lot of us feel is due to diminished screening during the COVID-19 pandemic. 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It's the most common cancer in men in the United States, after skin cancer, and it is also the second most common cause of cancer death. So, there's a lot known about the fact that early diagnosis of prostate cancer leads to significantly better outcomes, both with screening tests and with early detection. ","_key":"a1d11175c1d10","_type":"span"}],"_type":"block"},{"_key":"2a64e1cd1e25","markDefs":[],"children":[{"text":"I think Prostate Cancer Awareness Month really capitalizes on the public awareness for men who may be unaware of their risk of prostate cancer [and making sure they're] educated on it, them and their loved ones, [so they can] understand what the symptoms and the management approach would be for prostate cancer. Because of its significant outsized importance as a very common cancer, the month of September is dedicated to increasing that awareness.","_key":"e17430ce07cc","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"marks":["strong"],"text":"We know that there are significant disparities in prostate cancer, with Black men being more likely to develop prostate cancer and more likely to die from it. Why does this occur?","_key":"880020244fe70","_type":"span"}],"_type":"block","style":"normal","_key":"ffcadab3c368","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Oh: ","_key":"1295df45ed15"},{"_type":"span","marks":[],"text":"I think this is a subject of continued active investigation. There probably are multiple reasons why African Americans are at greater risk of both developing prostate cancer and also of dying of it.","_key":"b8b281e8a0810"}],"_type":"block","style":"normal","_key":"c5a72463cd8c"},{"markDefs":[],"children":[{"marks":[],"text":"At least part of the disparity we know may be biological in nature, meaning that there may be some genetic risk factors that are more common in African American men than in others. We don't know what causes prostate cancer, but we know that there are genetic predispositions. There may also be environmental factors at play, including diet and environment. And then finally, there may be issues of health care access, which may be contributing.","_key":"cb1d3cb124b2","_type":"span"}],"_type":"block","style":"normal","_key":"c61def7e24f4"},{"children":[{"_type":"span","marks":[],"text":"So, my opinion is that there's probably multiple factors that lead to this disparity, this disparity in outcomes. 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We’re seeing a very rich pipeline in terms of more GNRH agents coming to market, beyond the agonists and antagonists that are oral, that are safer, and that have some clinically meaningful differentiation. [This includes] lowering cardiovascular [CV] risk, not just for men who have cardiovascular risk factors but for those who don’t, because age is already a risk factor. It’s an exciting time, but it starts with awareness. It starts with education around not just the risk itself but how meaningful the clinical differentiation is and how quickly the progression to the cardiac risk occurs and that degree of clinical differentiation. With safer alternatives within weeks, the curve starts separating in terms of cardiovascular risk reduction. There are alternative treatments and clinical differentiation, but we also have to highlight the unmet need through education, better risk-assessment tools, and shared decision support for providers and for patients and also for payers, so we understand the efficacy but also the safety and the potential implications for total cost of care.","_key":"ecd7d56606ac"}],"_type":"block"},{"_type":"block","style":"normal","_key":"0f9e5c434c85","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7eb009cf672d0"}]},{"_key":"380d9f4b2ec6","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Bhavesh Shah, RPh, BCOP: ","_key":"1cced1bb9d840"},{"_type":"span","marks":[],"text":"Historically, there’s not a single oncologist who doesn’t know the cardiovascular risk associated with patients with prostate cancer, with the therapies we give them. But we’ve seen historically that there’s conflicting evidence in terms of whether there’s an increased risk or it’s the same. [Or when there’s] not structured guidance when you have multiple organizations saying to do this or that. Not having uniform recommendations also brings out the wrong message to providers. There really needs to be this uniform, universal message across disciplines that there’s increased risk and here’s what you need to do. Maybe there are providers who know that there’s an existing cardiovascular risk, especially patients with preexisting cardiovascular risk. What do you do for them? What do you do for these patients besides instilling in them the fear of God that they’re going develop a cardiovascular event and they need to diet, they need to exercise, they need to stop smoking—all these lifestyle modifications. There are other interventions: is there room for using a drug that has a lower cardiotoxicity or lower cardiovascular-event concerns for patients with prostate cancer? I truly think that’s done through a randomized control trial or through real-world evidence that helps providers feel more comfortable. It’s not coming from meta-analysis or retrospective post-op analyses. It’s based on validated real-world evidence or randomized control trials.","_key":"1cced1bb9d841"}],"_type":"block","style":"normal"},{"children":[{"text":"","_key":"3505bf89eb420","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"0ff5588153c2","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"John L. Fox, MD, MHA: ","_key":"025f695639ac0"},{"marks":[],"text":"Is it likely in the near future that we’re going to have changes in how we manage prostate cancer with incorporation of cardiovascular risks into the treatment equation? I don’t know what’s going to change that. Until the NCCN [National Comprehensive Cancer Network], or the FDA, or somebody else comes out with a black-box warning that suggests we’re causing harm to patients, and that we should look for alternative strategies that reduce cardiovascular risk, it’s unlikely. It’s unfortunate. Absolutely. But I don’t see payers taking the lead in driving that, especially given the relative paucity of data. 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We do this already for patients with breast cancer, who receive anthracyclines. We make sure if they have a preexisting cardiovascular disease that we would have close collaboration with a cardiologist. When we have a patient with osteoporosis, it’s not the prostate oncologist who’s managing the patient for the osteoporosis but the endocrinologist. Unless they have metastatic to the bone, then the oncologist takes on that patient. But there’s already this model existing where we’re cross-collaborating with multidisciplinary specialty providers to manage oncology because it’s definitely becoming a complexity where patients are living longer and then seeing adverse effects. Even some drugs are causing patients to develop diabetes. Or we’re giving them drugs that are requiring significant adjustment in their diabetic medications. But you know that this isn’t the expertise of an oncologist. This is already happening. Having an alignment because we also see the cardiology providers have guidelines they abide by. Essentially, having that incorporated into their guidelines would create better education and collaboration with cardiologists and other disciplines that we may need to collaborate with in managing not just prostate cancer.","_key":"951a0ef4b84c1","_type":"span"}],"_type":"block","style":"normal","_key":"bfa08c2809c5","markDefs":[]},{"_type":"block","style":"normal","_key":"c8c9ce50b3f2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6dcd1701f2050"}]},{"_key":"c1205d98cbc7","markDefs":[],"children":[{"text":"John L. Fox, MD, MHA: ","_key":"1dbbb346c35b0","_type":"span","marks":["strong"]},{"_type":"span","marks":[],"text":"All of us would like to have a holistic approach to our care where we have multiple specialists opining on what the best therapy is. The reality is that most patients don’t get that holistic multispecialty approach to their treatment decision-making. It’s usually left to the urologist who’s initiating treatment and, sometimes, subsequently a referral to a medical oncologist. What would get us to the point where we had multispecialty approaches? It’s complicated because running a multidisciplinary clinic is expensive, and it’s not well reimbursed. In the near future, it’s unlikely that we’re going to have cardiologists involved in this decision-making process. It’s still possible if we increase awareness of cardiovascular risks: men die from cardiovascular disease with prostate cancer and not from prostate cancer.","_key":"1dbbb346c35b1"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"a019b07ab8580"}],"_type":"block","style":"normal","_key":"626c3fe1946c","markDefs":[]},{"style":"normal","_key":"83943f1e4d98","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We talked earlier about the role of decision-support tools at the point of care. We talked about the role of guidelines, pathways, and professional society recommendations. But I suspect that for the patient with metastatic castrate-resistant prostate cancer, it’s unlikely we’re going to have multispecialty clinics in the near future.","_key":"3776bdd499820"}],"_type":"block"},{"_type":"block","style":"normal","_key":"4b7e323e962d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"100c4d4df0ff0"}]},{"markDefs":[],"children":[{"text":"Maria Lopes, MD, MS: ","_key":"b7141012fbed0","_type":"span","marks":["strong"]},{"_type":"span","marks":[],"text":"This is the ultimate wish: having a multidisciplinary approach to the management of the patient who has prostate cancer. Also, the shared decision-making component that does need to exist helps patients understand their options. But who owns the patient when they have cancer? Especially if they have long survival, which is great news. It may be the PCP [primary care provider], the oncologist, or the urologist early on.","_key":"b7141012fbed1"}],"_type":"block","style":"normal","_key":"9def91c019c8"},{"_key":"d539a74c6f0b","markDefs":[],"children":[{"marks":[],"text":"","_key":"1ae7cc1b01c70","_type":"span"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"a80b6c8286c3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"How can we have a more integrated team-based approach? It’s important to educate care managers as they’re interacting with patients and caregivers but also multiple providers or specialists. To be able to direct the proper education, to be able to also have the right risk tools, to understand the context of patient age and risk factors, [and to] make the appropriate treatment selection so that at the end, we can optimize care and outcomes. 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We don’t usually call out prostate cancer and ADT [androgen deprivation therapy] as a risk. There’s usually a heavy focus on HEDIS [Healthcare Effectiveness Data and Information Set] measures, which are part of NCQA [National Committee for Quality Assurance] accreditation, star performance measures, because that’s how CMS [Centers for Medicare \u0026 Medicaid Services]rewards us. To the extent that there’s a measure that focuses on prostate cancer and the risk of ADT and it’s actionable in terms of what we should be doing in terms of either outreach or education, that becomes important to accelerate this knowledge of ADT risk superimposed on cardiovascular risk and prostate cancer. General awareness may not be there at this time. Unless there’s a specific measure, we may still continue to, at a population level, look for cardiac risk factors, independent of whether you have prostate cancer. This adds another element of opportunities, specifically looking at cardiac risk, treatment medications, and perhaps how long you’ve even been a treatment. That highlights the magnitude of the risk benefit and perhaps something actionable that you can do to minimize the risk.","_key":"cfac288ec4391","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7a8ea6fc0c190"}],"_type":"block","style":"normal","_key":"c151db057ba4"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Understanding the safety issues with each product, we’re calling out as an informational note if someone already has cardiovascular risk, to assess risk benefit with a particular treatment if it has been demonstrated to compound cardiovascular risk. For agents who have less risk, we’re helping providers do a better assessment of risk benefit. If they have somebody with significant cardiovascular risk reduction, perhaps [we’re providing] a crosswalk to treatments that are safer—equally effective but safer alternatives. Hopefully we’re making the right decisions that are evidence based, but we’re not adding significantly to cost, hospitalizations, and events related to what already is a significant risk for that individual.","_key":"00428f23e2f80"}],"_type":"block","style":"normal","_key":"6655650b6f2c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1a0ebbaf5c370"}],"_type":"block","style":"normal","_key":"c5885ecfa13c"},{"children":[{"_type":"span","marks":[],"text":"There are a lot of unmet needs for tools for clinicians and payers to identify what these patients are because we do this at a population level. But there’s not necessarily a crosswalk if you have prostate cancer or you’re on an ADT and you call out the subpopulation for further intervention. There’s certainly an opportunity for payers and providers to identify alternatives, and if they’re safer, to consider those in the management strategy.","_key":"e475a285c92b0"}],"_type":"block","style":"normal","_key":"9b8f32b92fae","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ddc805c920db"}],"_type":"block","style":"normal","_key":"5b3fe53af636"},{"_key":"f02301f23d20","markDefs":[],"children":[{"_type":"span","marks":["strong","em"],"text":"Transcript edited for clarity.","_key":"bb6bd5b7f8c8"}],"_type":"block","style":"normal"}],"factCheckAuthorMapping":null,"_id":"1be18f58-e23d-4db9-b272-8846a89e5f5a","published":"2022-04-06T13:00:00.000Z","seoTag":["prostate cancer","CVD","cardiovascular disease","CVD risk","quality measures","population health","risk-benefit ration","coverage policies","cost of care","management 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We’re doing meta-analysis. We have small phase 2 randomized controlled trials. We could use a randomized control trial to bring light to all the things we need to manage these patients better. But we may not have the luxury to do a randomized control trial. Imagine doing a randomized control trial to show cardiovascular events related to an intervention. It could take years, and the magnitude of the patients you need may be significant amount.","_key":"aeb21916446b1","_type":"span"}],"_type":"block","style":"normal","_key":"5c5a2425c08d"},{"_key":"c1c8f2961a8b","markDefs":[],"children":[{"marks":[],"text":"","_key":"6ac46c48752f0","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"This is where we could use real-world evidence. We have endorsement even from government agencies like the FDA. They’re already using real-world evidence to approve therapies that would take years to do randomized controlled trials. They have a framework to get more evidence for specific diseases, for specific interventions. So real-world evidence would be huge in terms of getting evidence efficiently to providers in managing this disease from a perspective of better, safer treatments.","_key":"da2702fd11850"}],"_type":"block","style":"normal","_key":"5953f370f418"},{"_key":"0e4bf42872d5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e496ca56337e0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Maria Lopes, MD, MS: ","_key":"32d177ca58cd0"},{"text":"There’s certainly an opportunity for real-world data as new treatment options emerge that appear to be safer. Following this through in terms of real-world evidence, that helps demonstrate that, on the background of comorbidities, there may be different risk classifications from a cardiovascular-risk or other risk perspective and the numbers needed to treat to avoid an event.","_key":"32d177ca58cd1","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"6479ad716775"},{"style":"normal","_key":"3bfb8ab78934","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c88df1292b4f0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"Data help us understand the degree of clinical differentiation, both in the short and long term, with implications for total cost of care, reducing cardiovascular-risk reduction and [measuring] how quickly that occurs—to be able to demonstrate clinical benefit and financial return. There’s definitely an opportunity for real-world data and also for risk tools. Risk tools that can be embedded in the EMR [electronic medical record] or used for predictive analytics to call out patients who may be at higher risk with something actionable. That can be considered and perhaps allow oncologists across multiple specialties opportunities for education. There’s a more holistic view on the cause and effect of treatments related to cancer and their impact on the context of age, comorbidities, and other risk factors, so better decision-making can occur and so we’re not only evidence based but also cost conscious.","_key":"6878d31c17e10"}],"_type":"block","style":"normal","_key":"eb88ee7e615b","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"5271594624920","_type":"span"}],"_type":"block","style":"normal","_key":"4e63672bd3d2"},{"_type":"block","style":"normal","_key":"28f3a32cad40","markDefs":[],"children":[{"_key":"33720d88e1300","_type":"span","marks":["strong"],"text":"John L. Fox, MD, MHA:"},{"_type":"span","marks":[],"text":" The key question for everyone regarding cardiovascular morbidity and mortality and the impact these drugs have in men with prostate cancer is what type of evidence would be compelling? What type of evidence would be compelling to a health plan to prefer 1 therapy over another? What type of evidence would be compelling to a medical oncologist as they’re making treatment decisions? What type of evidence would be compelling to the NCCN [National Comprehensive Cancer Network] as it writes its guidelines in preferring antagonists, which the evidence suggests lowers cardiovascular morbidity and mortality compared with agonists? What type of evidence would be compelling?","_key":"33720d88e1301"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7a7e7117c9c10"}],"_type":"block","style":"normal","_key":"3c55c22f2692"},{"style":"normal","_key":"743c3e2d41bf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We have 1 clinical trial, 80 patients, that showed that patients receiving GNRH antagonists had lower cardiovascular morbidity and mortality, yet that hasn’t changed health plan decision-making. It hasn’t changed physician decision-making. It hasn’t changed the guidelines. So what type of evidence would be compelling? I don’t think we’re going to have large head-to-head trials in the future, so the most likely place the evidence will come from is real-world evidence. There are challenges with real-world evidence, including the elimination of bias or confounders in the analysis. That would be the most compelling evidence. Health plans are unlikely to make a move on preferring antagonists over agonists unless there’s a recommendation from the NCCN.","_key":"f0de799eafc80"}],"_type":"block"},{"_key":"479dfbe242e3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"425faaf6e1ca0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"If there was clear evidence, including supported by guidelines, that GNRH agonists increase the risk of cardiovascular disease and that GNRH antagonists should be used preferentially, how do we affect that change? How do we ensure that patients get the appropriate therapy? There are probably a couple of ways of doing that. One is to use decision-support tools at the time of ordering therapy. Many EMRs, including oncology EMRs, have the ability to deliver that information to providers.","_key":"4e9a620068140"}],"_type":"block","style":"normal","_key":"1e69224bd1cb"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ca281cc789200"}],"_type":"block","style":"normal","_key":"6583e3214069"},{"_type":"block","style":"normal","_key":"f24783bd693c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The other way to do that could be through health plans. If there’s evidence that agonists are inferior and that we should be using antagonists instead, then we could implement that at the level of the health plan. Today, though, that GNRH agonists like Lupron [leuprorelin] aren’t prior authorized, at least in the plan that I’ve most recently worked with, whereas GNRH antagonists are. So if we were to want to implement that, we’d have to change our policies and procedures around how we manage those therapies. I’d also note that education is going to be critical. I cited evidence earlier that 75% of men initiating treatment for prostate cancer with GNRH analogs have preexisting cardiovascular events or are at high risk for cardiovascular events, yet the market share for GNRH agonists is 97% compared with about 3% for GNRH antagonists. There’s a lopsided distribution compared with the risk that exists.","_key":"721c3e7996720"}]},{"children":[{"marks":[],"text":"","_key":"49d78d6547bf","_type":"span"}],"_type":"block","style":"normal","_key":"bc6c8e6e406f","markDefs":[]},{"children":[{"_key":"4a05ec094063","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"0c529d778194","markDefs":[]},{"style":"normal","_key":"1b6a66a7e457","markDefs":[],"children":[{"text":"Transcript edited for clarity.","_key":"6bc8d6b9e56d","_type":"span","marks":["strong","em"]}],"_type":"block"}],"internalTag":["prostate cancer","CVD","cardiovascular 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Fox, MD, MHA: ","_key":"81d26fe1559e0"},{"_type":"span","marks":[],"text":"As physicians, all of us want to improve patients’ longevity of life and quality of life. Because medicine is specialized and fragmented, the urologist is primarily looking at ways to improve the patients’ survival from their prostate cancer, when they have advanced prostate cancer. I don’t think we’re looking more comprehensively at how we can improve overall life expectancy. If we were to do that, we’d acknowledge that since 1995, cardiovascular mortality has exceeded prostate cancer mortality in patients with prostate cancer and incorporate that into our decision-making.","_key":"81d26fe1559e1"}],"_type":"block"},{"_type":"block","style":"normal","_key":"73db52c3ab72","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7d83e37a03130"}]},{"markDefs":[],"children":[{"text":"Unfortunately, I don’t think we have a good mechanism for looking at overall mortality in these patients and incorporating cardiovascular-risk factors into treatment decision-making. In the future, if we’re going to reduce total cost of care, we need to think about what the relative trade-offs are in those therapies. Ideally, if we could find a way of improving overall life expectancy, reducing prostate cancer mortality, and reducing cardiovascular mortality, that would be ideal. At the end of the day, the question is, is there good evidence to support therapies that reduce cardiovascular mortality, and what’s the relative cost of that? If we had a therapy that reduced the total cost of care, including the cost of the drug, who would argue against that?","_key":"fe707b7e24410","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"3b63a65ee7c2"},{"style":"normal","_key":"26ffcaab0bf9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8cbe4638d1490"}],"_type":"block"},{"_key":"9783dc3fc6c6","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Maria Lopes, MD, MS: ","_key":"6058b385bfc80"},{"_type":"span","marks":[],"text":"In general, we look at efficacy [and] safety. Safety usually is at a high level in terms of adverse events. More becomes available in terms of clinical differentiation, particularly with respect to safety, event reduction, numbers needed to treat to avoid an event, and how different treatment options compare. That becomes really important. Many times we don’t have that information to be able to compare across regiments. Also, it starts to be more focused in the guidelines to help providers help patients make better-informed decisions, as well as for payers. We’re in a P\u0026T [pharmacy and therapeutics] committee, trying to put together [or] look at prior authorizations, perhaps on what we should include. These become interesting opportunities to consider patient segmentation, and perhaps be proactive in terms of analytics to identify opportunities to educate providers, as we look holistically at the impact of treatment on other comorbid conditions and total costs.","_key":"6058b385bfc81"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"88d9f843a960","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7b98eab465b10"}]},{"_key":"d1392350ef88","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"John L. Fox, MD, MHA:","_key":"a40d1dec1eda0"},{"_type":"span","marks":[],"text":" Every health plan has a pharmacy and therapeutics committee where we evaluate new therapies for the treatment of any condition, including prostate cancer. The primary thing we’re looking at is the efficacy of that treatment in terms of reducing the unintended consequence of that disease, which in this case would be death. But we don’t consider safety or toxicities associated with that in our decisions. That’s the role of the medical oncologist and patient to weigh the risks and benefits of those therapies. That said, unless there’s a black-box warning on a drug, those adverse effects, or unintended consequences of a treatment, aren’t considered. In this space, should we be considering the cardiovascular unintended consequences? We probably should be. The fact of the matter is, that’s not commonly considered in our decision-making. In other words, the preponderance of evidence, although it’s not strong evidence, suggests that GNRH antagonists reduce cardiovascular risks compared with cardiovascular agonists. But they’re not in a preferred position, and we don’t require antagonist compared with agonist.","_key":"a40d1dec1eda1"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"cf007dc0aabf"}],"_type":"block","style":"normal","_key":"986f317bad91","markDefs":[]},{"children":[{"_type":"span","marks":["strong","em"],"text":"Transcript edited for clarity.","_key":"773aee165075"}],"_type":"block","style":"normal","_key":"6a7fc0c2691f","markDefs":[]}],"factCheckAuthorMapping":null,"url":{"current":"factors-in-evaluating-therapy-for-prostate-cancer","_type":"slug"},"updatedOn":null,"_updatedAt":"2022-03-07T20:45:41Z","documentGroupMapping":[{"_ref":"e2239e11-3a71-4962-b6cd-df32cfbc3c96","_type":"reference","_key":"49b358ba00d7"}],"taxonomyMapping":[{"name":"Prostate Cancer","_id":"a16ec324-112c-426d-a4a3-5d84ba7a87cf","_updatedAt":"2023-11-03T18:15:46Z","identifier":"prostate-cancer","parent":{"_ref":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_type":"reference"},"cmeType":"per","_rev":"J9E0v654gKdSlGLhTDCgfg","_type":"taxonomy","perKeywordMapping":["Genitourinary Cancer","Health Equity Diversity \u0026 Inclusion"],"_createdAt":"2020-11-06T18:47:16Z"}],"is_visible":true,"documentGroup":{"_ref":"e2239e11-3a71-4962-b6cd-df32cfbc3c96","_type":"reference"},"_id":"92009ad8-7f78-40c3-a322-99db7e5337e6","ExcludeFromPubMedXML":false,"_createdAt":"2022-03-07T20:45:41Z","link":"/view/factors-in-evaluating-therapy-for-prostate-cancer"},{"_createdAt":"2022-03-07T20:41:48Z","_updatedAt":"2022-03-07T20:41:48Z","seoTag":["prostate cancer","CVD","cardiovascular disease","alternative payment models","CVD risk","cost of care","risk-bearing practices"],"showSocialShare":true,"body":[{"videoID":"6290391939001","source":"brightcove","_key":"14a574f38278","_type":"video"},{"children":[{"marks":[],"text":"","_key":"6adee0f31239","_type":"span"}],"_type":"block","style":"normal","_key":"2138e3804291","markDefs":[]},{"markDefs":[],"children":[{"marks":["strong"],"text":"Transcript:","_key":"7cb5c6496d10","_type":"span"}],"_type":"block","style":"normal","_key":"104dd71bac22"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Bhavesh Shah, RPh, BCOP: ","_key":"868d575f66e60"},{"_type":"span","marks":[],"text":"There’s definitely an impact on alternative payment models when you have patients with prostate cancer or any malignancy. Thinking about the cardiovascular implications we have, especially because we just talked about patients [who are] African American. No matter if they have low risk or intermediate risk, they probably have a much higher risk of mortality and cardiovascular events from the prostate cancer therapies that we have, specifically ADT [androgen deprivation therapy]. As a payer, we were more looking at the total cost of care. If you’re in a risk-based agreement or you own and operate a payer, you’re aware of these things if you’re in this type of model or in the risk-based agreement. There are full-risk models, and there are dual-risk models. There’s definitely a lot more awareness around the alternative payment models that drive some of the outcomes, which impact the total cost of care. As a payer and a provider, I think there’s more that we need to see around the total cost of care from these complications and comorbidities that we’ve seen historically for decades.","_key":"868d575f66e61"}],"_type":"block","style":"normal","_key":"0d5e4e1e8a83"},{"style":"normal","_key":"1965f83448fa","markDefs":[],"children":[{"text":"","_key":"59a79905d1720","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"How have we changed our practice by having better drugs, better screening, better treatment, better awareness to manage total cost of care? If we’re able to show that, [then you have] these alternative payment models, which aren’t focused on cardiovascular events related to prostate cancer but can be. You have a direct link that shows that if you have prostate cancer, if you’re Black, and if you have ADT, your risk of developing mortality is X, Y, Z, and it’s going to increase the total cost of care for a payer. What’s the most optimal therapy that this patient should be on? Is it going to be a drug that reduces cardiovascular risk for that patient? [We need to] change the treatment landscape if we’re able to connect the dots from more evidence.","_key":"55b6f57907950"}],"_type":"block","style":"normal","_key":"ee960447f941"},{"children":[{"_key":"1fdc86581c870","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"28940b783761","markDefs":[]},{"_key":"bf36991db5da","markDefs":[],"children":[{"text":"Maria Lopes, MD, MS: ","_key":"0138fc3fa45d0","_type":"span","marks":["strong"]},{"_type":"span","marks":[],"text":"It’s about understanding and looking at patient whole health, understanding the implication for total cost of care, and understanding from an oncologist standpoint, which tends to focus on oncology. In the context of age and comorbid conditions, treatment selection may matter in terms of implications for total costs of care. It raises the need to a higher level, both in terms of analytics, as well as care coordination and integration of care among treatment providers.","_key":"0138fc3fa45d1"}],"_type":"block","style":"normal"},{"children":[{"_key":"ca42c17cc2f50","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"f8a6685b3240","markDefs":[]},{"children":[{"_key":"2903679119d90","_type":"span","marks":[],"text":"At a time when we’re under accountable care [organizations], we’re trying to manage risk and total costs, regardless of comorbidities and across different silos. It certainly highlights an amazing opportunity where you look at compounding that risk. It doesn’t take years to see what kind of an impact ADT can have on increasing cardiovascular-risk reduction and what can be done to mitigate that risk. Multiple provider groups can hopefully work together around shared decision-making and around making the appropriate treatment selections that can impact total cost of care."}],"_type":"block","style":"normal","_key":"ad028e87bb9d","markDefs":[]},{"_type":"block","style":"normal","_key":"ce2a1a17204e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f169310c2520"}]},{"_type":"block","style":"normal","_key":"31314afc3b53","markDefs":[],"children":[{"_key":"ee8922990fd2","_type":"span","marks":["strong","em"],"text":"Transcript edited for clarity."}]}],"documentGroupMapping":[{"_key":"9a5a6c553f9e","_ref":"e2239e11-3a71-4962-b6cd-df32cfbc3c96","_type":"reference"}],"factCheckAuthorMapping":null,"summary":"Continuing their discussion on cost of care in prostate cancer, experts reflect on how cardiovascular disease impacts risk-bearing practices and alternative payment models.","link":"/view/cvd-in-prostate-cancer-risk-bearing-practices-and-alternative-payment-models","internalTag":["prostate cancer","CVD","cardiovascular disease"],"_rev":"DAih6bqk0qBEh5HKrk6BCg","published":"2022-03-23T13:20:00.000Z","authorMapping":[{"url":{"current":"john-l-fox-md-mha","_type":"slug"},"displayName":"John L. 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