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Integrated Approach to Pain in Hemodialysis Patients | NIH HEAL Initiative
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paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> <div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-43461b5d5c46e52e72a6ad52e0bfc2df9f49b40c3aa3bb04ca0d22afc0278ede"> <div id="carousel-1182140018" class="callout carousel no-controllers pol slide" data-ride="carousel"> <div class="carousel-inner"> <p><strong>Research Spotlights</strong></p> <div class="carousel-item active"> <span class="carousel-item-container"> <div class="card overlay-body" id="hope-for-managing-pain"> <a href="/news/stories/HOPE-for-managing-pain" aria-label="HOPE for Managing Pain"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/21-0229%20GettyImages-1139130075_940x788%20%281%29.jpg?itok=AQTbYN2W" width="900" height="507" alt="A man receiving dialysis " class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/HOPE-for-managing-pain"> HOPE for Managing Pain </a> </p> </div> </div> </div> </div> </span> </div> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview</h2> <h3>The Research Need</h3> <p>Pain is a common problem in Medicare end-stage renal disease (ESRD) hemodialysis patients. The rate of chronic opioid prescriptions in ESRD hemodialysis patients, approximately 20 percent, is higher than the rate in Medicare comparison populations.</p> <p>ESRD hemodialysis patients are an ideal population in which to launch and monitor interventions because of their long-term participation in monitored treatment and the availability of data resources. To date, many interventions, both behavioral and medical, have not been tried in this population or have not been rigorously evaluated by randomized controlled trials. These interventions could reduce the rate of opioid prescription and opioid use and could address related issues, such as depression, anxiety, and pain.</p> <h3>About the Program</h3> <p>The Hemodialysis Opioid Prescription Effort (HOPE) consortium will develop an intervention to address the problems of pain and opioid use in U.S. hemodialysis populations. The consortium will initiate multipronged pain treatment tailored to each patient, without opioids, and using buprenorphine and other novel agents to reduce dependence on opioids in affected patients.</p> <p>Analyses will consider comorbid illnesses, such as diabetes and mental health disorders, and social determinants of health, such as socioeconomic status, social isolation, social support, residential factors, and perception of racial discrimination. The goal is to identify novel risk factors for pain and opioid use in this population.</p> <p>End points will be chronic opioid prescription rates, prescription drug doses, pain control, patient satisfaction with care, perception of quality of life, hospitalization rates, and mortality rates. The consortium may use electronic health records to capture real-time risk factor and outcomes data by leveraging and expanding a pilot set of more than 200 standardized data elements that the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Chronic Kidney Disease eCare Plan Working Group identified and prioritized for comprehensive chronic kidney disease care.</p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-56e7002ef4c010b26d62116084408e16424deb5b08c9e89ab4a325f6e8a33fa8"> <h2>Open Funding Opportunities </h2> There are no Open Funding Opportunities at this time. </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-1652772969" class="col-12 accordion"> <div class="card-header col-12" id="heading-1652772969-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1652772969-0" aria-expanded="false" aria-controls="collapse-1652772969-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-1652772969-0" class="collapse " aria-labelledby="heading-1652772969-0" data-parent="#accordion-1652772969"> <div class="card-body"> <h3>Clinical Centers</h3> <ul> <li><strong>Hennepin Healthcare Research Institute</strong> – Minnesota</li> <li><strong>Massachusetts General Hospital</strong> – Massachusetts</li> <li><strong>New York University</strong> – New York</li> <li><strong>University of Illinois, Chicago</strong> – Illinois</li> <li><strong>University of Pittsburgh</strong> – Pennsylvania</li> <li><strong>University of Washington</strong> – Washington</li> <li><strong>Vanderbilt University</strong> – Tennessee</li> <li><strong>Yale University</strong> – Connecticut</li> </ul> <h3>Scientific and Data Research Center</h3> <ul> <li><strong>University of Pennsylvania</strong> – Pennsylvania</li> </ul> </div> </div> </div> <div id="accordion-243956193" class="col-12 accordion"> <div class="card-header col-12" id="heading-243956193-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-243956193-1" aria-expanded="false" aria-controls="collapse-243956193-1"> Funded Projects </button> </h2> </div> <div id="collapse-243956193-1" class="collapse " aria-labelledby="heading-243956193-1" data-parent="#accordion-243956193"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-4b0cf4472709999bc4e3efed0e81835e23ef22559618477f3deb713832e547a1"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Creating a multi-level intervention to reduce stigma for buprenorphine use for individuals with End Stage Kidney Disease and Chronic Pain </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=181#project-title-38446> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=181#project-title-38446">Summary</a> </div> <div class="col-6 d-lg-none"> Sep 29, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> University of Illinois at Chicago Hemodialysis Opioid Prescription Effort (HOPE) Clinical Center </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=181#project-title-38466> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=181#project-title-38466">Summary</a> </div> <div class="col-6 d-lg-none"> Sep 29, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Pain Reduction and Opioid MedIcation Safety in ESRD (PROMISE) study </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=181#project-title-34731> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=181#project-title-34731">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Video-Telecare Collaborative Pain Management to Improve Function and Reduce Opioid Risk in Patients with End Stage Renal Disease Receiving Hemodialysis </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=181#project-title-33836> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=181#project-title-33836">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Randomized ESRD Trial COmparing CBT alone VERsus with buprenorphine (RECOVER) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=181#project-title-35156> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=181#project-title-35156">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" href=/funding/awarded?research_program=181> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contact </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#53383a3e3e363f23133e323a3f7d3d3a3b7d343c25">Paul L. Kimmel, M.D.</a><br /> NIDDK</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Participating NIH Institutes, Centers, and Offices</h3> <p><ul> <li><a href="https://www.niddk.nih.gov/">National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)</a></li> <li><a href="https://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul> <li><a href="https://heal.nih.gov/research/clinical-research/health-equity-pain-management">Advancing Health Equity in Pain Management</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/back-pain">Back Pain Consortium Research Program (BACPAC)</a></li> <li><a href="https://heal.nih.gov/research/preclinical-translational/biomarkers">Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/eppic-net">Early Phase Pain Investigation Clinical Network (EPPIC Net)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/integrative-management-chronic-pain">Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/pain-management-research">Pain Management Effectiveness Research Network (ERN)</a></li> <li><a href="https://heal.nih.gov/research/clinical-research/prism">PRagmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated February 21, 2025</p> </div> </div> </div> <footer class="fluid-container p-3 footer" role="contentinfo"> <div class="container"> <div class="row"> <div class="col-12 col-md-3"> <div class="footer-logo"><a href="/"><img alt="NIH HEAL Initiative" src="/assets/HEAL_Initaitive_White.svg" /></a></div> <h2>Contact Us</h2> <p>Please send email to <a href="/cdn-cgi/l/email-protection#eca4a9ada09d99899f98858382ac8388c2828584c28b839a"><span class="__cf_email__" 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