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Prevention of Progression to Opioid Use Disorder | NIH HEAL Initiative
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class="gtm-breadcrumb">Research</a></li> <li class="breadcrumb-item gtm-breadcrumb"><a href="/research/new-strategies" class="gtm-breadcrumb">New Strategies To Prevent and Treat Opioid Addiction</a></li> <li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Prevention of Progression to Moderate or Severe Opioid Use Disorder</li> </ol> </nav> </div> </div> <div class="col-sm-12 col-md-5"> </div> </div> </div> <div class="layout-content"> <div> <div id="block-particle-content"> <h1> Prevention of Progression to Moderate or Severe Opioid Use Disorder </h1> <div> <div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div class='row'> <div> <div class="col-12 col-xl-6 float-right"> <div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-8b5f36979bc1e655d7a3987363c9952f3bed228d14084f11eb4cf5f475b583b3"> <div id="carousel-2126169665" class="callout carousel no-controllers pol slide" data-ride="carousel"> <div class="carousel-inner"> <p><strong>Research Spotlights</strong></p> <div class="carousel-item active"> <span class="carousel-item-container"> <div class="card overlay-body" id="stopping-opioid-misuse-in-its-tracks"> <a href="/news/stories/stopping-opioid-misuse" aria-label="Stopping Opioid Misuse in its Tracks"> <div> <div class="visually-hidden field-label">Image</div> <img loading="lazy" src="/files/styles/callout_carousel/public/STOP-GettyImages-1264330859.jpg?itok=xE9hviKs" width="900" height="507" alt="woman sitting at a table working on a laptop computer" class="img-fluid" /> </div> </a> <div class="card-body"> <div class="center-card-body"> <div class="center-card-body-content"> <p class="card-title"> <a href="/news/stories/stopping-opioid-misuse"> Stopping Opioid Misuse in its Tracks </a> </p> </div> </div> </div> </div> </span> </div> </div> </div> </div> </div> </div> <p class='col-12'> <h2>Overview</h2> <h3>The Research Need</h3> <p>According to the Substance Abuse and Mental Health Service Administration’s 2018 National Survey on Drug Use and Health, an estimated 10.3 million people in the U.S. misused opioids in the past year. Of these individuals, only 2 million met the criteria for opioid use disorder (OUD).</p> <p>Very little is known about the efficacy of interventions for people who do not meet the criteria for moderate or severe OUD. The prevalence of subthreshold OUD in primary care settings is 5-10 percent, and rates are higher (21-29 percent) among those receiving prescribed opioids. Those with subthreshold OUD are at high risk of developing moderate or severe OUD and/or dying from an overdose, and more empirical evidence is needed about pragmatic prevention interventions that integrated general medical settings can adopt.</p> <h3>About the Program</h3> <p>To study the efficacy of prevention interventions to arrest the progression from risky opioid use to more severe OUD, researchers will test the efficacy of a Subthreshold Opioid Use Disorder Prevention (STOP) intervention in primary care settings. Risky opioid use is defined as (1) having taken prescribed opioids for nonmedical use or having used illicit opioids and (2) meeting no more than three of five diagnostic criteria for OUD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.</p> <p>STOP adopts an early intervention approach based on a collaborative care model and consists of:</p> <ul> <li>A practice-embedded nurse care manager who provides patient education and supports the primary care provider (PCP) in engaging, monitoring, and guiding patients who have risky opioid use.</li> <li>Brief advice delivered to patients by their PCP.</li> <li>Phone counseling by behavioral health providers to motivate patients and support behavior change.</li> </ul> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-7a080d0da474307e93421021e2bef9dfb88eea5f071ebf5b661cb5d93ec3c312"> <h2>Open Funding Opportunities </h2> There are no Open Funding Opportunities at this time. </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Program Details </h2> <div class="basic-content-grid-no-media"> <div> <p>To date, through the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup>, NIH has contributed $12.6 million to fund this clinical trial within the National Drug Abuse Treatment Clinical Trials Network (CTN).</p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> Research Examples </h2> <div class="basic-content-grid-no-media"> <div> <p>Researchers will determine whether STOP reduces risky opioid use. They will also examine the impact of STOP on progression to moderate or severe OUD, overdose risk behavior, and overdose events in adults with risky use of illicit or prescription opioids.</p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="container"> <div class="pattern"> <div id="accordion-1691501649" class="col-12 accordion"> <div class="card-header col-12" id="heading-1691501649-0"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-1691501649-0" aria-expanded="false" aria-controls="collapse-1691501649-0"> Funded Institutions and Locations </button> </h2> </div> <div id="collapse-1691501649-0" class="collapse " aria-labelledby="heading-1691501649-0" data-parent="#accordion-1691501649"> <div class="card-body"> <ul> <li><strong>Emmes Corporation </strong>– Maryland</li> <li><strong>McLean Hospital</strong> – Massachusetts</li> <li><a><strong>New York University School of Medicine </strong>– New York</a></li> <li><strong>University of California, San Francisco</strong> – California</li> </ul> </div> </div> </div> <div id="accordion-458950061" class="col-12 accordion"> <div class="card-header col-12" id="heading-458950061-1"> <h2 class="mb-0"> <button class="btn btn-link h2 expand-link" data-toggle="collapse" data-target="#collapse-458950061-1" aria-expanded="false" aria-controls="collapse-458950061-1"> Funded Projects </button> </h2> </div> <div id="collapse-458950061-1" class="collapse " aria-labelledby="heading-458950061-1" data-parent="#accordion-458950061"> <div class="card-body"> <div class="views-element-container form-group"><div class="viewsreference--view-title"> </div> <div class="js-view-dom-id-522b446d484ec85cf795138c4b10ee630f05ed21ab41aefa5b1500fdb57c2109"> <div class="pattern"> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Subthreshold Opioid Use Disorder Prevention (STOP); which will test the efficacy of a primary care Subthreshold Opioid Use Disorder Prevention (STOP) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=131#project-title-35691> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=131#project-title-35691">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Subthreshold Opioid Use Disorder Prevention (STOP); which will test the efficacy of a primary care Subthreshold Opioid Use Disorder Prevention (STOP) </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=131#project-title-35456> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=131#project-title-35456">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Subthreshold Opioid Use Disorder Prevention (STOP) Trial </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=131#project-title-35676> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=131#project-title-35676">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Subthreshold Opioid Use Disorder Prevention (STOP) Trial </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=131#project-title-35866> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=131#project-title-35866">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> <div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;"> <div class="col-3 d-none d-lg-block"> 2020 </div> <div class="col-lg-6 col-md-12"> Subthreshold Opioid Use Disorder Prevention (STOP) Trial </div> <div class="col-3 d-none d-lg-block"> <a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=131#project-title-35461> Summary </a> </div> <div class="col-6 d-lg-none"> <a href="/funding/awarded?research_program=131#project-title-35461">Summary</a> </div> <div class="col-6 d-lg-none"> Mar 19, 2020 </div> </div> </div> <div style="text-align:right;"> <a class="btn btn-primary" href=/funding/awarded?research_program=131> View all </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default"> <div class='container'> <div class='pattern'> <div class="content-card-grid"> <div class="row"> <div class="col-md-4 order-1"> <div class='card gradient'> <div class='card-body'> <h3 class='card-title'> Contact </h3> <div class='card-text'> <p><a href="/cdn-cgi/l/email-protection#c8afadadbca0a9e6bbbdaabaa9a5a9a6a1a9a588a6a1a0e6afa7be">Geetha Subramaniam, Ph.D.</a><br>NIDA</p> </div> </div> </div> </div> <div class="col-md-8 order-2"> <h3>Participating NIH Institutes, Centers, and Offices</h3> <p><ul> <li><a href="https://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li> </ul> </p> </div> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default"> <div class='container'> <div class="dynamic_content"> </div> </div> </div> <div class="paragraph paragraph--type--basic-content paragraph--view-mode--default"> <div class="container"> <div class='basic-content content-align-left pattern'> <div class='basic-content-grid-container ' style=''> <h2 class='basic-content-grid-h2-no-media'> View Other Research Programs in This Focus Area </h2> <div class="basic-content-grid-no-media"> <div> <ul><li><a href="https://heal.nih.gov/research/new-strategies/care-polysubstance-use-primary-care">Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care)</a></li><li><a href="https://heal.nih.gov/research/new-strategies/optimizing-care">Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions</a></li><li><a href="https://heal.nih.gov/research/new-strategies/duration-retention-discontinuation">Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder</a></li><li><a href="https://heal.nih.gov/research/new-strategies/preventing-opioid-use-disorder">Preventing Opioid Use Disorder</a></li><li><a href="https://heal.nih.gov/research/new-strategies/sleep-dysfunction">Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery</a></li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <div class="container"> <p class="last-updated">Page last updated January 11, 2025</p> </div> </div> </div> <footer class="fluid-container p-3 footer" role="contentinfo"> <div class="container"> <div class="row"> <div class="col-12 col-md-3"> <div 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