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<span>Characteristics</span> </div> </a> <button aria-controls="toc-Characteristics-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Characteristics subsection</span> </button> <ul id="toc-Characteristics-sublist" class="vector-toc-list"> <li id="toc-Cultivars" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cultivars"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Cultivars</span> </div> </a> <ul id="toc-Cultivars-sublist" class="vector-toc-list"> <li id="toc-Noble_and_non-noble_kava" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Noble_and_non-noble_kava"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.1</span> <span>Noble and non-noble kava</span> </div> </a> <ul id="toc-Noble_and_non-noble_kava-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Growing_regions" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Growing_regions"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.2</span> <span>Growing regions</span> </div> </a> <ul id="toc-Growing_regions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Relationship_with_kawakawa" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Relationship_with_kawakawa"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1.3</span> <span>Relationship with kawakawa</span> </div> </a> <ul id="toc-Relationship_with_kawakawa-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Composition" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Composition"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Composition</span> </div> </a> <ul id="toc-Composition-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Pharmacology" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Pharmacology"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Pharmacology</span> </div> </a> <button aria-controls="toc-Pharmacology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Pharmacology subsection</span> </button> <ul id="toc-Pharmacology-sublist" class="vector-toc-list"> <li id="toc-Constituents" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Constituents"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Constituents</span> </div> </a> <ul id="toc-Constituents-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacodynamics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacodynamics"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Pharmacodynamics</span> </div> </a> <ul id="toc-Pharmacodynamics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Detection" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Detection"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Detection</span> </div> </a> <ul id="toc-Detection-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Preparations" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Preparations"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Preparations</span> </div> </a> <button aria-controls="toc-Preparations-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Preparations subsection</span> </button> <ul id="toc-Preparations-sublist" class="vector-toc-list"> <li id="toc-Traditional_preparation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Traditional_preparation"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Traditional preparation</span> </div> </a> <ul id="toc-Traditional_preparation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Supplements_and_pharmaceutical_preparations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Supplements_and_pharmaceutical_preparations"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Supplements and pharmaceutical preparations</span> </div> </a> <ul id="toc-Supplements_and_pharmaceutical_preparations-sublist" class="vector-toc-list"> <li id="toc-Concerns" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Concerns"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2.1</span> <span>Concerns</span> </div> </a> <ul id="toc-Concerns-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Kava_culture" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Kava_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Kava culture</span> </div> </a> <ul id="toc-Kava_culture-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Kava_bars" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Kava_bars"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.4</span> <span>Kava bars</span> </div> </a> <ul id="toc-Kava_bars-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Effects_of_consumption" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Effects_of_consumption"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Effects of consumption</span> </div> </a> <ul id="toc-Effects_of_consumption-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Toxicity,_safety,_and_potential_side_effects" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Toxicity,_safety,_and_potential_side_effects"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Toxicity, safety, and potential side effects</span> </div> </a> <button aria-controls="toc-Toxicity,_safety,_and_potential_side_effects-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Toxicity, safety, and potential side effects subsection</span> </button> <ul id="toc-Toxicity,_safety,_and_potential_side_effects-sublist" class="vector-toc-list"> <li id="toc-General_observations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#General_observations"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>General observations</span> </div> </a> <ul id="toc-General_observations-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Effects_on_the_liver" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Effects_on_the_liver"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Effects on the liver</span> </div> </a> <ul id="toc-Effects_on_the_liver-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Other_adverse_reactions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Other_adverse_reactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Other adverse reactions</span> </div> </a> <ul id="toc-Other_adverse_reactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Potential_interactions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Potential_interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.4</span> <span>Potential interactions</span> </div> </a> <ul id="toc-Potential_interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Kava_dermopathy" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Kava_dermopathy"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.5</span> <span>Kava dermopathy</span> </div> </a> <ul id="toc-Kava_dermopathy-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Research" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Research"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Research</span> </div> </a> <ul id="toc-Research-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Traditional_medicine" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Traditional_medicine"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Traditional medicine</span> </div> </a> <ul id="toc-Traditional_medicine-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Regulation" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Regulation"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Regulation</span> </div> </a> <button aria-controls="toc-Regulation-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Regulation subsection</span> </button> <ul id="toc-Regulation-sublist" class="vector-toc-list"> <li id="toc-Australia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Australia"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.1</span> <span>Australia</span> </div> </a> <ul id="toc-Australia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Europe" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Europe"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.2</span> <span>Europe</span> </div> </a> <ul id="toc-Europe-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-New_Zealand" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#New_Zealand"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.3</span> <span>New Zealand</span> </div> </a> <ul id="toc-New_Zealand-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-North_America" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#North_America"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.4</span> <span>North America</span> </div> </a> <ul id="toc-North_America-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vanuatu" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vanuatu"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.5</span> <span>Vanuatu</span> </div> </a> <ul id="toc-Vanuatu-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Kava</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 48 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-48" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">48 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Kawa" title="Kawa – Afrikaans" lang="af" hreflang="af" data-title="Kawa" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D8%A7%D9%81%D8%A7" title="كافا – Arabic" lang="ar" hreflang="ar" data-title="كافا" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Asturian" lang="ast" hreflang="ast" data-title="Piper methysticum" data-language-autonym="Asturianu" data-language-local-name="Asturian" class="interlanguage-link-target"><span>Asturianu</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Belarusian" lang="be" hreflang="be" data-title="Piper methysticum" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bi mw-list-item"><a href="https://bi.wikipedia.org/wiki/Kava" title="Kava – Bislama" lang="bi" hreflang="bi" data-title="Kava" data-language-autonym="Bislama" data-language-local-name="Bislama" class="interlanguage-link-target"><span>Bislama</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Catalan" lang="ca" hreflang="ca" data-title="Piper methysticum" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Pep%C5%99ovn%C3%ADk_opojn%C3%BD" title="Pepřovník opojný – Czech" lang="cs" hreflang="cs" data-title="Pepřovník opojný" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Kava" title="Kava – Danish" lang="da" hreflang="da" data-title="Kava" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Kava" title="Kava – German" lang="de" hreflang="de" data-title="Kava" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Spanish" lang="es" hreflang="es" data-title="Piper methysticum" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Kavao" title="Kavao – Esperanto" lang="eo" hreflang="eo" data-title="Kavao" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D8%A7%D9%88%D8%A7" title="کاوا – Persian" lang="fa" hreflang="fa" data-title="کاوا" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Kava" title="Kava – French" lang="fr" hreflang="fr" data-title="Kava" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Galician" lang="gl" hreflang="gl" data-title="Piper methysticum" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%B9%B4%EB%B0%94_(%EC%8B%9D%EB%AC%BC)" title="카바 (식물) – Korean" lang="ko" hreflang="ko" data-title="카바 (식물)" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hsb mw-list-item"><a href="https://hsb.wikipedia.org/wiki/Kawowy_popjerjowc" title="Kawowy popjerjowc – Upper Sorbian" lang="hsb" hreflang="hsb" data-title="Kawowy popjerjowc" data-language-autonym="Hornjoserbsce" data-language-local-name="Upper Sorbian" class="interlanguage-link-target"><span>Hornjoserbsce</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Kava" title="Kava – Indonesian" lang="id" hreflang="id" data-title="Kava" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Italian" lang="it" hreflang="it" data-title="Piper methysticum" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Latin" lang="la" hreflang="la" data-title="Piper methysticum" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Kava" title="Kava – Latvian" lang="lv" hreflang="lv" data-title="Kava" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Svaigusis_pipiras" title="Svaigusis pipiras – Lithuanian" lang="lt" hreflang="lt" data-title="Svaigusis pipiras" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Kava" title="Kava – Hungarian" lang="hu" hreflang="hu" data-title="Kava" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%9A%D0%B0%D0%B2%D0%B0" title="Кава – Macedonian" lang="mk" hreflang="mk" data-title="Кава" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%95%E0%B4%BE%E0%B4%B5" title="കാവ – Malayalam" lang="ml" hreflang="ml" data-title="കാവ" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D9%83%D8%A7%D9%81%D8%A7" title="كافا – Egyptian Arabic" lang="arz" hreflang="arz" data-title="كافا" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Kava" title="Kava – Malay" lang="ms" hreflang="ms" data-title="Kava" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-fj mw-list-item"><a href="https://fj.wikipedia.org/wiki/Yaqona" title="Yaqona – Fijian" lang="fj" hreflang="fj" data-title="Yaqona" data-language-autonym="Na Vosa Vakaviti" data-language-local-name="Fijian" class="interlanguage-link-target"><span>Na Vosa Vakaviti</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Kava_(plant)" title="Kava (plant) – Dutch" lang="nl" hreflang="nl" data-title="Kava (plant)" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AB%E3%83%B4%E3%82%A1" title="カヴァ – Japanese" lang="ja" hreflang="ja" data-title="カヴァ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Kava" title="Kava – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Kava" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Pieprz_metystynowy" title="Pieprz metystynowy – Polish" lang="pl" hreflang="pl" data-title="Pieprz metystynowy" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Piper_methysticum" title="Piper methysticum – Portuguese" lang="pt" hreflang="pt" data-title="Piper methysticum" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ty mw-list-item"><a href="https://ty.wikipedia.org/wiki/%E2%80%99ava" title="’ava – Tahitian" lang="ty" hreflang="ty" data-title="’ava" data-language-autonym="Reo tahiti" data-language-local-name="Tahitian" class="interlanguage-link-target"><span>Reo tahiti</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Kava" title="Kava – Romanian" lang="ro" hreflang="ro" data-title="Kava" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9F%D0%B5%D1%80%D0%B5%D1%86_%D0%BE%D0%BF%D1%8C%D1%8F%D0%BD%D1%8F%D1%8E%D1%89%D0%B8%D0%B9" title="Перец опьяняющий – Russian" lang="ru" hreflang="ru" data-title="Перец опьяняющий" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Kava" title="Kava – Simple English" lang="en-simple" hreflang="en-simple" data-title="Kava" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Kava_kava" title="Kava kava – Slovenian" lang="sl" hreflang="sl" data-title="Kava kava" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-szl mw-list-item"><a href="https://szl.wikipedia.org/wiki/Kava_kava" title="Kava kava – Silesian" lang="szl" hreflang="szl" data-title="Kava kava" data-language-autonym="Ślůnski" data-language-local-name="Silesian" class="interlanguage-link-target"><span>Ślůnski</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Kava_(usev)" title="Kava (usev) – Serbian" lang="sr" hreflang="sr" data-title="Kava (usev)" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Kava_(usev)" title="Kava (usev) – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Kava (usev)" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Kavapippuri" title="Kavapippuri – Finnish" lang="fi" hreflang="fi" data-title="Kavapippuri" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://sv.wikipedia.org/wiki/Kava" title="Kava – Swedish" lang="sv" hreflang="sv" data-title="Kava" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%95%E0%AE%B5%E0%AE%BE_(%E0%AE%9A%E0%AF%86%E0%AE%9F%E0%AE%BF)" title="கவா (செடி) – Tamil" lang="ta" hreflang="ta" data-title="கவா (செடி)" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%84%E0%B8%B2%E0%B8%A7%E0%B8%B2" title="คาวา – Thai" lang="th" hreflang="th" data-title="คาวา" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-to mw-list-item"><a href="https://to.wikipedia.org/wiki/Kava" title="Kava – Tongan" lang="to" hreflang="to" data-title="Kava" data-language-autonym="Lea faka-Tonga" data-language-local-name="Tongan" class="interlanguage-link-target"><span>Lea faka-Tonga</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Kava" title="Kava – Turkish" lang="tr" hreflang="tr" data-title="Kava" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9F%D0%B5%D1%80%D0%B5%D1%86%D1%8C_%D0%BF%27%D1%8F%D0%BD%D0%BA%D0%B8%D0%B9" title="Перець п'янкий – Ukrainian" lang="uk" hreflang="uk" 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id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Piper_methysticum" hreflang="en"><span>Wikimedia Commons</span></a></li><li class="wb-otherproject-link wb-otherproject-species mw-list-item"><a href="https://species.wikimedia.org/wiki/Piper_methysticum" hreflang="en"><span>Wikispecies</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q161067" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div 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i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about the plant. For the class of pharmacological derivatives, see <a href="/wiki/Kavalactone" title="Kavalactone">Kavalactone</a>. For other uses, see <a href="/wiki/Kava_(disambiguation)" class="mw-disambig" title="Kava (disambiguation)">Kava (disambiguation)</a>.</div> <p class="mw-empty-elt"> </p> <table class="infobox biota" style="text-align: left; width: 200px; font-size: 100%"> <tbody><tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(180,250,180)">Kava </th></tr> <tr> <td colspan="2" style="text-align: center"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Starr_070515-7054_Piper_methysticum.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Starr_070515-7054_Piper_methysticum.jpg/220px-Starr_070515-7054_Piper_methysticum.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Starr_070515-7054_Piper_methysticum.jpg/330px-Starr_070515-7054_Piper_methysticum.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Starr_070515-7054_Piper_methysticum.jpg/440px-Starr_070515-7054_Piper_methysticum.jpg 2x" data-file-width="2816" data-file-height="2112" /></a></span> </td></tr> <tr> <td colspan="2" style="text-align: center; font-size: 88%"><i>Piper methysticum</i> leaves </td></tr> <tr> <th colspan="2" style="color:inherit; min-width:15em; text-align: center; background-color: rgb(180,250,180)"><a href="/wiki/Taxonomy_(biology)" title="Taxonomy (biology)">Scientific classification</a> <span class="plainlinks taxobox-edit-taxonomy skin-invert" style="font-size:smaller; float:right; padding-right:0.4em; margin-left:-3em;"><span typeof="mw:File"><a href="/wiki/Template:Taxonomy/Piper" title="Edit this classification"><img alt="Edit this classification" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/15px-OOjs_UI_icon_edit-ltr.svg.png" decoding="async" width="15" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/23px-OOjs_UI_icon_edit-ltr.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/30px-OOjs_UI_icon_edit-ltr.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span> </th></tr> <tr> <td>Kingdom: </td> <td><a href="/wiki/Plant" title="Plant">Plantae</a> </td></tr> <tr> <td><i>Clade</i>: </td> <td><a href="/wiki/Vascular_plant" title="Vascular plant">Tracheophytes</a> </td></tr> <tr> <td><i>Clade</i>: </td> <td><a href="/wiki/Flowering_plant" title="Flowering plant">Angiosperms</a> </td></tr> <tr> <td><i>Clade</i>: </td> <td><a href="/wiki/Magnoliids" title="Magnoliids">Magnoliids</a> </td></tr> <tr> <td>Order: </td> <td><a href="/wiki/Piperales" title="Piperales">Piperales</a> </td></tr> <tr> <td>Family: </td> <td><a href="/wiki/Piperaceae" title="Piperaceae">Piperaceae</a> </td></tr> <tr> <td>Genus: </td> <td><a href="/wiki/Piper_(plant)" title="Piper (plant)"><i>Piper</i></a> </td></tr> <tr> <td>Species: </td> <td><div style="display:inline" class="species"><i><b>P. methysticum</b></i></div> </td></tr> <tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(180,250,180)"><a href="/wiki/Binomial_nomenclature" title="Binomial nomenclature">Binomial name</a> </th></tr> <tr> <td colspan="2" style="text-align: center"><b><span class="binomial"><span style="font-weight:normal;"></span><i>Piper methysticum</i></span></b><br /><div style="font-size: 85%;"><a href="/wiki/Georg_Forster" title="Georg Forster">G.Forst.</a></div> </td></tr> </tbody></table><style data-mw-deduplicate="TemplateStyles:r1238732961">@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-night .mw-parser-output .infobox.biota img{background:transparent}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-os .mw-parser-output .infobox.biota img{background:white}}.mw-parser-output .infobox.biota .taxobox-edit-taxonomy img{background:transparent!important}body.skin-vector .mw-parser-output table.biota.infobox{margin-top:0.5em}body.skin--responsive .mw-parser-output table.biota.infobox tr.taxonrow td{padding:2px 10px}</style> <p><b>Kava</b> or <b>kava kava</b> (<i><b>Piper methysticum</b></i>: <a href="/wiki/Latin" title="Latin">Latin</a> 'pepper' and Latinized <a href="/wiki/Ancient_Greek" title="Ancient Greek">Greek</a> 'intoxicating') is a crop of the <a href="/wiki/Pacific_Islands" class="mw-redirect" title="Pacific Islands">Pacific Islands</a>.<sup id="cite_ref-mwd_1-0" class="reference"><a href="#cite_note-mwd-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> The name <i>kava</i> is from <a href="/wiki/Tongan_language" title="Tongan language">Tongan</a> and <a href="/wiki/Marquesan_language" title="Marquesan language">Marquesan</a>, meaning 'bitter';<sup id="cite_ref-mwd_1-1" class="reference"><a href="#cite_note-mwd-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> other names for kava include <i>ʻawa</i> (<a href="/wiki/Hawaii" title="Hawaii">Hawaiʻi</a>),<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Samoa_%27ava_ceremony" class="mw-redirect" title="Samoa 'ava ceremony"><i>ʻava</i></a> (<a href="/wiki/Samoa" title="Samoa">Samoa</a>), <i>yaqona</i> or <i>yagona</i> (<a href="/wiki/Fiji" title="Fiji">Fiji</a>),<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> <i>sakau</i> (<a href="/wiki/Pohnpei" title="Pohnpei">Pohnpei</a>),<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> <i>seka</i> (<a href="/wiki/Kosrae" title="Kosrae">Kosrae</a>),<sup id="cite_ref-Lebot1992_5-0" class="reference"><a href="#cite_note-Lebot1992-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> and <i>malok</i> or <i>malogu</i> (parts of <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a>).<sup id="cite_ref-:1_6-0" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Kava is consumed for its <a href="/wiki/Sedation" title="Sedation">sedating effects</a> throughout the <a href="/wiki/Pacific_Ocean" title="Pacific Ocean">Pacific Ocean</a> cultures of <a href="/wiki/Polynesia" title="Polynesia">Polynesia</a>, including <a href="/wiki/Hawaii" title="Hawaii">Hawaii</a> and <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a>, <a href="/wiki/Melanesia" title="Melanesia">Melanesia</a>, some parts of <a href="/wiki/Micronesia" title="Micronesia">Micronesia</a>, such as <a href="/wiki/Pohnpei" title="Pohnpei">Pohnpei</a> and <a href="/wiki/Kosrae" title="Kosrae">Kosrae</a>, and the <a href="/wiki/Philippines" title="Philippines">Philippines</a>. </p><p>The <a href="/wiki/Root" title="Root">root</a> of the plant is used to produce a drink with <a href="/wiki/Sedative" title="Sedative">sedative</a>, <a href="/wiki/Anesthetic" title="Anesthetic">anesthetic</a>, and <a href="/wiki/Euphoria" title="Euphoria">euphoriant</a> properties. Its active ingredients are called <a href="/wiki/Kavalactone" title="Kavalactone">kavalactones</a>.<sup id="cite_ref-wang_7-0" class="reference"><a href="#cite_note-wang-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> A 2003 <a href="/wiki/Systematic_review" title="Systematic review">systematic review</a> concluded it had a small effect for treating short-term <a href="/wiki/Anxiety_disorder" title="Anxiety disorder">anxiety</a>.<sup id="cite_ref-pittler_8-0" class="reference"><a href="#cite_note-pittler-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Moderate consumption of kava in its traditional form, i.e., as a water-based suspension of kava roots, has been deemed to present an "acceptably low level of health risk" by the <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a>.<sup id="cite_ref-fao-who_9-0" class="reference"><a href="#cite_note-fao-who-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> However, consumption of kava <a href="/wiki/Extract" title="Extract">extracts</a> produced with <a href="/wiki/Organic_solvents" class="mw-redirect" title="Organic solvents">organic solvents</a>, or excessive amounts of poor-quality kava products, may be linked to an increased risk of adverse health outcomes, including potential <a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">liver injury</a>.<sup id="cite_ref-fao-who_9-1" class="reference"><a href="#cite_note-fao-who-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kuchta_1647–1653_10-0" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_11-0" class="reference"><a href="#cite_note-:0-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r886046785">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="History_and_names">History and names</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=1" title="Edit section: History and names"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Domesticated_plants_and_animals_of_Austronesia" title="Domesticated plants and animals of Austronesia">Domesticated plants and animals of Austronesia</a></div> <p>Kava is conspecific with <i>Piper wichmannii,</i> indicating Kava was domesticated from <i>Piper wichmannii</i> (syn. <i>Piper subbullatum</i>).<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Ross2008Lexicon_13-0" class="reference"><a href="#cite_note-Ross2008Lexicon-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Kava originated in Fiji and spread through the pacific by <a href="/wiki/Polynesian_navigation" title="Polynesian navigation">Polynesian navigation</a>. </p><p>It was spread by the <a href="/wiki/Austronesian_peoples" title="Austronesian peoples">Austronesian</a> <a href="/wiki/Lapita_culture" title="Lapita culture">Lapita culture</a> after contact eastward into the rest of <a href="/wiki/Polynesia" title="Polynesia">Polynesia</a>. It is endemic to <a href="/wiki/Oceania" title="Oceania">Oceania</a> and is not found in other Austronesian groups. Kava reached <a href="/wiki/Hawaii" title="Hawaii">Hawaii</a>, but it is absent in <a href="/wiki/New_Zealand" title="New Zealand">New Zealand</a>, where it cannot grow.<sup id="cite_ref-Ross2008Lexicon_13-1" class="reference"><a href="#cite_note-Ross2008Lexicon-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lebot1989_14-0" class="reference"><a href="#cite_note-Lebot1989-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-temarareoKava_15-0" class="reference"><a href="#cite_note-temarareoKava-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Consumption of kava is also believed to be the reason why <a href="/wiki/Betel_nut_chewing" title="Betel nut chewing">betel nut chewing</a>, ubiquitous elsewhere, was lost for Austronesians in Oceania.<sup id="cite_ref-blusttrusell_16-0" class="reference"><a href="#cite_note-blusttrusell-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>According to Lynch (2002), the reconstructed <a href="/wiki/Proto-Polynesian_language" title="Proto-Polynesian language">Proto-Polynesian</a> term for the plant, <i>*kava</i>, was derived from the <a href="/wiki/Proto-Oceanic_language" title="Proto-Oceanic language">Proto-Oceanic</a> term <i>*kawaR</i> in the sense of a "bitter root" or "potent root [used as fish poison]". It may have been related to reconstructed <i>*wakaR</i> (in Proto-Oceanic and <a href="/wiki/Proto-Malayo-Polynesian_language" title="Proto-Malayo-Polynesian language">Proto-Malayo-Polynesian</a>) via <a href="/wiki/Metathesis_(linguistics)" title="Metathesis (linguistics)">metathesis</a>. It originally referred to <i><a href="/wiki/Zingiber_zerumbet" title="Zingiber zerumbet">Zingiber zerumbet</a></i>, used to make a similar mildly psychoactive bitter drink in Austronesian rituals. Cognates for <i>*kava</i> include <a href="/wiki/Pohnpeian_language" title="Pohnpeian language">Pohnpeian</a> <i>sa-kau</i>; <a href="/wiki/Tongan_language" title="Tongan language">Tongan</a>, <a href="/wiki/Niue_language" class="mw-redirect" title="Niue language">Niue</a>, <a href="/wiki/Rapa_Nui_language" title="Rapa Nui language">Rapa Nui</a>, <a href="/wiki/Tuamotuan_language" title="Tuamotuan language">Tuamotuan</a>, and <a href="/wiki/Rarotongan_language" class="mw-redirect" title="Rarotongan language">Rarotongan</a> <i>kava</i>; <a href="/wiki/Samoan_language" title="Samoan language">Samoan</a>, <a href="/wiki/Tahitian_language" title="Tahitian language">Tahitian</a>, and <a href="/wiki/Marquesan_language" title="Marquesan language">Marquesan</a> <i>ʻava</i>; and <a href="/wiki/Hawaiian_language" title="Hawaiian language">Hawaiian</a> <i>ʻawa</i>. In some languages, most notably <a href="/wiki/M%C4%81ori_language" title="Māori language">Māori</a> <i>kawa</i>, the cognates have come to mean "bitter", "sour", or "acrid" to the taste.<sup id="cite_ref-Ross2008Lexicon_13-2" class="reference"><a href="#cite_note-Ross2008Lexicon-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lynch2002_17-0" class="reference"><a href="#cite_note-Lynch2002-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Heathcote2012_18-0" class="reference"><a href="#cite_note-Heathcote2012-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-McLean2014_19-0" class="reference"><a href="#cite_note-McLean2014-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>In the <a href="/wiki/Cook_Islands" title="Cook Islands">Cook Islands</a>, the reduplicated forms of <i>kawakawa</i> or <i>kavakava</i> are also applied to the unrelated members of the genus <i><a href="/wiki/Pittosporum" title="Pittosporum">Pittosporum</a></i>. In other languages, such as <a href="/wiki/Futunan_language" title="Futunan language">Futunan</a>, compound terms like <i>kavakava atua</i> refer to other species belonging to the genus <i><a href="/wiki/Piper_(genus)" class="mw-redirect" title="Piper (genus)">Piper</a></i>. The <a href="/wiki/Reduplication" title="Reduplication">reduplication</a> of the base form is indicative of falsehood or likeness, in the sense of "false kava".<sup id="cite_ref-temarareoKawakawa_20-0" class="reference"><a href="#cite_note-temarareoKawakawa-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-temarareoKava_15-1" class="reference"><a href="#cite_note-temarareoKava-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> In <a href="/wiki/New_Zealand" title="New Zealand">New Zealand</a>, it was applied to the kawakawa (<i><a href="/wiki/Piper_excelsum" title="Piper excelsum">Piper excelsum</a></i>), which is <a href="/wiki/Endemic" class="mw-redirect" title="Endemic">endemic</a> to New Zealand and nearby <a href="/wiki/Norfolk_Island" title="Norfolk Island">Norfolk Island</a> and <a href="/wiki/Lord_Howe_Island" title="Lord Howe Island">Lord Howe Island</a>. It was exploited by the Māori based on previous knowledge of the kava, as the latter could not survive in the colder climates of New Zealand. The <a href="/wiki/M%C4%81ori_language" title="Māori language">Māori</a> name for the plant, <i>kawakawa</i>, is derived from the same <a href="/wiki/Etymon" class="mw-redirect" title="Etymon">etymon</a> as kava, but <a href="/wiki/Reduplicated" class="mw-redirect" title="Reduplicated">reduplicated</a>. It is a sacred tree among the <a href="/wiki/M%C4%81ori_people" title="Māori people">Māori people</a>. It is seen as a symbol of death, corresponding to the rangiora (<i><a href="/wiki/Brachyglottis_repanda" title="Brachyglottis repanda">Brachyglottis repanda</a></i>), which is the symbol of life. However, <i>kawakawa</i> has no psychoactive properties. Its connection to kava is linked to its similarity in appearance and bitter taste.<sup id="cite_ref-temarareoKawakawa_20-1" class="reference"><a href="#cite_note-temarareoKawakawa-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Characteristics">Characteristics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=2" title="Edit section: Characteristics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kava was historically grown only in the <a href="/wiki/Hawaiian_Islands" title="Hawaiian Islands">Pacific islands of Hawaii</a>, <a href="/wiki/Federated_States_of_Micronesia" title="Federated States of Micronesia">Federated States of Micronesia</a>, <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a>, <a href="/wiki/Fiji" title="Fiji">Fiji</a>, the <a href="/wiki/Samoa" title="Samoa">Samoas</a>, and <a href="/wiki/Tonga" title="Tonga">Tonga</a>. An <a href="/wiki/Inventory" title="Inventory">inventory</a> of <i>P. methysticum</i> distribution showed it was cultivated on numerous islands of <a href="/wiki/Micronesia" title="Micronesia">Micronesia</a>, <a href="/wiki/Melanesia" title="Melanesia">Melanesia</a>, <a href="/wiki/Polynesia" title="Polynesia">Polynesia</a>, and <a href="/wiki/Hawaii" title="Hawaii">Hawaii</a>, whereas specimens of <i>P. wichmannii</i> were all from <a href="/wiki/Papua_New_Guinea" title="Papua New Guinea">Papua New Guinea</a>, the <a href="/wiki/Solomon_Islands" title="Solomon Islands">Solomon Islands</a>, and Vanuatu.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Traditionally, plants are harvested around four years of age, as older plants have higher concentrations of kavalactones. After reaching about 2 metres (6.6 ft) in height, plants grow a wider stalk and additional stalks, but not much taller. The roots can reach a depth of 60 centimetres (2.0 ft). </p> <div class="mw-heading mw-heading3"><h3 id="Cultivars">Cultivars</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=3" title="Edit section: Cultivars"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg/220px-John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg" decoding="async" width="220" height="298" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/ff/John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg/330px-John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/ff/John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg/440px-John_LaFarge_-_Young_Girls_Preparing_Kava_Outside_of_the_Hut_Whose_Posts_Are_Decorated_wih_Flowers.jpg 2x" data-file-width="797" data-file-height="1081" /></a><figcaption>Painting showing women preparing kava by <a href="/wiki/John_La_Farge" title="John La Farge">John La Farge</a> (<abbr title="circa">c.</abbr><span style="white-space:nowrap;"> 1891</span>).</figcaption></figure> <p>Kava consists of sterile cultivars cloned from its wild ancestor, <i>Piper wichmanii</i>.<sup id="cite_ref-:1_6-1" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Today it comprises hundreds of different cultivars grown across the Pacific. Each cultivar has not only different requirements for successful cultivation, but also displays unique characteristics both in terms of its appearance and its psychoactive properties.<sup id="cite_ref-:1_6-2" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Noble_and_non-noble_kava">Noble and non-noble kava</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=4" title="Edit section: Noble and non-noble kava"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Scholars make a distinction between the so-called noble and non-noble kava. The latter category comprises the so-called tudei (or "two-day") kavas, medicinal kavas, and wild kava (<i>Piper wichmanii</i>, the ancestor of domesticated <i>Piper methysticum</i>).<sup id="cite_ref-:1_6-3" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Teschke_2503–2516_22-0" class="reference"><a href="#cite_note-Teschke_2503–2516-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> Traditionally, only noble kavas have been used for regular consumption, due to their more favourable composition of kavalactones and other compounds that produce more pleasant effects and have lower potential for causing negative side effects, such as nausea, or "kava hangover".<sup id="cite_ref-:1_6-4" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kuchta_1647–1653_10-1" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The perceived benefits of noble cultivars explain why only these cultivars were spread around the Pacific by Polynesian and Melanesian migrants, with presence of non-noble cultivars limited to the islands of Vanuatu, from which they originated.<sup id="cite_ref-:1_6-5" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> More recently, it has been suggested that the widespread use of tudei cultivars in the manufacturing of several kava products might have been the key factor contributing to the rare reports of adverse reactions to kava observed among the consumers of kava-based products in Europe.<sup id="cite_ref-Kuchta_1647–1653_10-2" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Tudei varieties have traditionally not been grown in Hawaii and Fiji, but in recent years there have been reports of farmers attempting to grow "isa" or "palisi" non-noble cultivars in Hawaii, and of imports of dried tudei kava into Fiji for further re-exporting.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> The tudei cultivars may be easier and cheaper to grow: while it takes up to 5 years for noble kava to mature, non-noble varieties can often be harvested just one year after being planted. </p><p>The concerns about the adverse effects of non-noble varieties, produced by their undesirable composition of kavalactones and high concentrations of potentially harmful compounds (<a href="/wiki/Flavokavain" title="Flavokavain">flavokavains</a>, which are not present in any significant concentration in the noble varieties), have led to legislation prohibiting exports from countries such as Vanuatu.<sup id="cite_ref-Kuchta_1647–1653_10-3" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Likewise, efforts have been made to educate non-traditional customers about the difference between noble and non-noble varieties and that non-noble varieties do not offer the same results as noble cultivars.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> In recent years, government regulatory bodies and non-profit NGOs have been set up with the declared aim of monitoring kava quality; producing regular reports; certifying vendors selling proper, noble kava; and warning customers against products that may contain tudei varieties.<sup id="cite_ref-teschke2011_26-0" class="reference"><a href="#cite_note-teschke2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Growing_regions">Growing regions</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=5" title="Edit section: Growing regions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In Vanuatu, exportation of kava is strictly regulated. Only cultivars classified as noble are allowed to be exported. Only the most desirable cultivars for everyday drinking are classified as noble to maintain quality control. In addition, their laws mandate that exported kava must be at least five years old and farmed organically. Their most popular noble cultivars are "Borogu" or "Borongoru" from <a href="/wiki/Pentecost_Island" class="mw-redirect" title="Pentecost Island">Pentecost Island</a>, "Melomelo" from <a href="/wiki/Aoba_Island" class="mw-redirect" title="Aoba Island">Aoba Island</a> (called <i>Sese</i> in the north <a href="/wiki/Pentecost_Island" class="mw-redirect" title="Pentecost Island">Pentecost Island</a>), and "Palarasul" kava from <a href="/wiki/Espiritu_Santo" title="Espiritu Santo">Espiritu Santo</a>. In Vanuatu, Tudei ("two-day") kava is reserved for special ceremonial occasions and exporting it is not allowed. "Palisi" is a popular Tudei variety. </p><p>In <a href="/wiki/Hawaii" title="Hawaii">Hawaii</a>, there are many other cultivars of kava (<a href="/wiki/Hawaiian_language" title="Hawaiian language">Hawaiian</a>: <i lang="haw">ʻawa</i>). Some of the most popular cultivars are <i>Mahakea</i>, <i>Moʻi</i>, <i>Hiwa</i>, and <i>Nene</i>. The <i><a href="/wiki/Ali%CA%BBi" title="Aliʻi">Aliʻi</a></i> (kings) of <a href="/wiki/Ancient_Hawaii" title="Ancient Hawaii">precolonial Hawaii</a> coveted the <i>Moʻi</i> variety, which had a strong cerebral effect due to a predominant amount of the <a href="/wiki/Kavalactone" title="Kavalactone">kavalactone</a> kavain. This sacred variety was so important to them that no one but royalty could ever experience it, "lest they suffer an untimely death". The reverence for Hiwa in old Hawaiʻi is evident in this portion of a chant recorded by <a href="/wiki/Nathaniel_Bright_Emerson" title="Nathaniel Bright Emerson">Nathaniel Bright Emerson</a> and quoted by E. S. Craighill and Elizabeth Green Handy: "This refers to the cup of sacramental ʻawa brewed from the strong, black ʻawa root (ʻawa hiwa), which was drunk sacramentally by the kumu hula": </p> <style data-mw-deduplicate="TemplateStyles:r1244412712">.mw-parser-output .templatequote{overflow:hidden;margin:1em 0;padding:0 32px}.mw-parser-output .templatequotecite{line-height:1.5em;text-align:left;margin-top:0}@media(min-width:500px){.mw-parser-output .templatequotecite{padding-left:1.6em}}</style><blockquote class="templatequote"><div class="poem"> <p>The day of revealing shall see what it sees: <br /> A seeing of facts, a sifting of rumors, <br /> An insight won by the black sacred 'awa, <br /> A vision like that of a god!<sup id="cite_ref-JohnstonRogers_27-0" class="reference"><a href="#cite_note-JohnstonRogers-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p> </div></blockquote> <p>Winter describes a <a href="/wiki/Hula" title="Hula">hula</a> prayer for inspiration that contains the line, <i>He ʻike pū ʻawa hiwa.</i> Pukui and Elbert translated this as "a knowledge from kava offerings". Winter explains that ʻawa, especially of the Hiwa variety, was offered to hula deities in return for knowledge and inspiration.<sup id="cite_ref-JohnstonRogers_27-1" class="reference"><a href="#cite_note-JohnstonRogers-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p><p>More recently, specialized kava varieties have been introduced to <a href="/wiki/South_Florida" title="South Florida">South Florida</a> which have been acclimated and adapted to grow well in South Florida's unique soil and climate and have significant resistance to pest and disease pressures. As of 2024, cultivation of these varieties is limited to a small number of commercial farms and backyard growers. </p> <div class="mw-heading mw-heading4"><h4 id="Relationship_with_kawakawa">Relationship with kawakawa</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=6" title="Edit section: Relationship with kawakawa"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Piper_excelsum_excelsum_G.Forst._(AM_AK347570-2).jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg/220px-Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg/330px-Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg/440px-Piper_excelsum_excelsum_G.Forst._%28AM_AK347570-2%29.jpg 2x" data-file-width="4000" data-file-height="2664" /></a><figcaption>Kawakawa (<i><a href="/wiki/Piper_excelsum" title="Piper excelsum">Piper excelsum</a></i>) plant may have been named by early <a href="/wiki/Polynesian_culture" title="Polynesian culture">Polynesian voyagers</a> to <a href="/wiki/New_Zealand" title="New Zealand">New Zealand</a> due to its similarities to kava.</figcaption></figure> <p>The Kawakawa (<i><a href="/wiki/Piper_excelsum" title="Piper excelsum">Piper excelsum</a></i>) plant, known also as "Māori kava", may be confused with kava. While the two plants look similar and have similar names, they are different, but related, species. Kawakawa is a small tree endemic to New Zealand, having importance to traditional medicine and <a href="/wiki/M%C4%81ori_culture" title="Māori culture">Māori culture</a>. As noted by the Kava Society of New Zealand, "in all likelihood, the kava plant was known to the first settlers of Aotearoa [New Zealand]. It is also possible that (just like the Polynesian migrants that settled in Hawaii) the Maori explorers brought some kava with them. Unfortunately, most of New Zealand is simply too cold for growing kava and hence the Maori settlers lost their connection to the sacred plant."<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> Further, "in New Zealand, where the climate is too cold for kava, the Maori gave the name kawa-kawa to another <i>Piperaceae M. excelsum</i>, in memory of the kava plants they undoubtedly brought with them and unsuccessfully attempted to cultivate. The Maori word kawa also means "ceremonial protocol", recalling the stylized consumption of the drug typical of Polynesian societies".<sup id="cite_ref-:1_6-6" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Kawakawa is commonly used in Maori traditional medicine for the treatment of skin infections, wounds, and cuts, and (when prepared as a tea) for stomach upsets and other minor illnesses.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Composition">Composition</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=7" title="Edit section: Composition"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Fresh kava root contains on average 80% <a href="/wiki/Water" title="Water">water</a>. Dried root contains approximately 43% <a href="/wiki/Starch" title="Starch">starch</a>, 20% <a href="/wiki/Dietary_fibre" class="mw-redirect" title="Dietary fibre">dietary fiber</a>, 15% <a href="/wiki/Kavalactone" title="Kavalactone">kavalactones</a>,<sup id="cite_ref-wang_7-1" class="reference"><a href="#cite_note-wang-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> 12% water, 3.2% <a href="/wiki/Sugar" title="Sugar">sugars</a>, 3.6% <a href="/wiki/Protein_(nutrient)" title="Protein (nutrient)">protein</a>, and 3.2% <a href="/wiki/Micronutrient" title="Micronutrient">minerals</a>. </p><p>In general, kavalactone content is greatest in the roots and decreases higher up the plant into the stems and leaves.<sup id="cite_ref-wang_7-2" class="reference"><a href="#cite_note-wang-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Relative concentrations of 15%, 10%, and 5% have been observed in the root, stump, and basal stems, respectively.<sup id="cite_ref-Lebot1992_5-1" class="reference"><a href="#cite_note-Lebot1992-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The relative content of kavalactones depends not only on plant segment but also on the kava plant variety, plant maturity, geographic location, and time of harvest.<sup id="cite_ref-wang_7-3" class="reference"><a href="#cite_note-wang-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The kavalactones present are <a href="/wiki/Kavain" title="Kavain">kavain</a>, <a href="/wiki/Demethoxyyangonin" class="mw-redirect" title="Demethoxyyangonin">demethoxyyangonin</a>, and <a href="/wiki/Yangonin" title="Yangonin">yangonin</a>, which are higher in the roots than in the stems and leaves, with <a href="/wiki/Dihydrokavain" title="Dihydrokavain">dihydrokavain</a>, <a href="/wiki/Methysticin" title="Methysticin">methysticin</a>, and <a href="/wiki/Dihydromethysticin" title="Dihydromethysticin">dihydromethysticin</a> also present.<sup id="cite_ref-wang_7-4" class="reference"><a href="#cite_note-wang-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>The mature roots of the kava plant are harvested after a minimum of four years (at least five years, ideally) for peak kavalactone content. Most kava plants produce around 50 kg (110 lb) of root when they are harvested. Kava root is classified into two categories: crown root (or chips) and lateral root. Crown roots are the large-diameter pieces that look like 1.5 to 5 inches (38 to 127 mm)-diameter wooden poker chips. Most kava plants consist of approximately 80% crown root upon harvesting. Lateral roots are smaller-diameter roots that look more like a typical root. A mature kava plant is about 20% lateral roots. Kava lateral roots have the highest content of kavalactones in the kava plant. "Waka" grade kava is made of lateral roots only. </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=8" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Constituents">Constituents</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=9" title="Edit section: Constituents"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Frame"><a href="/wiki/File:Kavalactone_General_Structure.PNG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/5/5f/Kavalactone_General_Structure.PNG" decoding="async" width="290" height="224" class="mw-file-element" data-file-width="290" data-file-height="224" /></a><figcaption>The general structure of the <a href="/wiki/Kavalactone" title="Kavalactone">kavalactones</a>, without the R<sub>1</sub>-R<sub>2</sub> -O-CH<sub>2</sub>-O- bridge and with all possible C=C double bonds shown.</figcaption></figure> <p>A total of 18 different <a href="/wiki/Kavalactone" title="Kavalactone">kavalactones</a> (or kavapyrones) have been identified to date, at least 15 of which are active.<sup id="cite_ref-pmid21073405_30-0" class="reference"><a href="#cite_note-pmid21073405-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> However, six of them, including <a href="/wiki/Kavain" title="Kavain">kavain</a>, <a href="/wiki/Dihydrokavain" title="Dihydrokavain">dihydrokavain</a>, <a href="/wiki/Methysticin" title="Methysticin">methysticin</a>, <a href="/wiki/Dihydromethysticin" title="Dihydromethysticin">dihydromethysticin</a>, <a href="/wiki/Yangonin" title="Yangonin">yangonin</a>, and <a href="/wiki/Desmethoxyyangonin" title="Desmethoxyyangonin">desmethoxyyangonin</a>, have been determined to be responsible for about 96% of the plant's pharmacological activity.<sup id="cite_ref-pmid21073405_30-1" class="reference"><a href="#cite_note-pmid21073405-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> Some minor constituents, including three <a href="/wiki/Chalcone" title="Chalcone">chalcones</a> — <a href="/wiki/Flavokavain_A" title="Flavokavain A">flavokavain A</a>, <a href="/wiki/Flavokavain_B" title="Flavokavain B">flavokavain B</a>, and <a href="/wiki/Flavokavain_C" title="Flavokavain C">flavokavain C</a> — have also been identified,<sup id="cite_ref-pmid21073405_30-2" class="reference"><a href="#cite_note-pmid21073405-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> as well as a toxic alkaloid (not present in the consumable parts of the plant<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup>), <a href="/wiki/Pipermethystine" title="Pipermethystine">pipermethystine</a>.<sup id="cite_ref-pmid21506562_32-0" class="reference"><a href="#cite_note-pmid21506562-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Alkaloid" title="Alkaloid">Alkaloids</a> are present in the roots and leaves.<sup id="cite_ref-drugs_33-0" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacodynamics">Pharmacodynamics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=10" title="Edit section: Pharmacodynamics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The following <a href="/wiki/Pharmacology" title="Pharmacology">pharmacological</a> actions have been reported for kava and/or its major active constituents:<sup id="cite_ref-pmid12383029_34-0" class="reference"><a href="#cite_note-pmid12383029-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Potentiation of <a href="/wiki/GABAA_receptor" title="GABAA receptor">GABA<sub>A</sub> receptor</a> activity (by kavain, dihydrokavain, methysticin, dihydromethysticin, and yangonin).</li> <li><a href="/wiki/Reuptake_inhibitor" title="Reuptake inhibitor">Inhibition</a> of the <a href="/wiki/Reuptake" title="Reuptake">reuptake</a> of <a href="/wiki/Norepinephrine" title="Norepinephrine">norepinephrine</a> (by kavain and methysticin) and possibly also of <a href="/wiki/Dopamine" title="Dopamine">dopamine</a> (by kavain and desmethoxyyangonin).</li> <li>Binding to the <a href="/wiki/CB1_receptor" class="mw-redirect" title="CB1 receptor">CB<sub>1</sub> receptor</a> (by yangonin).<sup id="cite_ref-pmid22525682_35-0" class="reference"><a href="#cite_note-pmid22525682-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup></li> <li>Inhibition of <a href="/wiki/Voltage-gated_sodium_channel" title="Voltage-gated sodium channel">voltage-gated sodium channels</a> and <a href="/wiki/Voltage-gated_calcium_channel" title="Voltage-gated calcium channel">voltage-gated calcium channels</a> (by kavain and methysticin).</li> <li><a href="/wiki/Monoamine_oxidase_B" title="Monoamine oxidase B">Monoamine oxidase B</a> reversible inhibition (by all six of the major kavalactones).</li></ul> <p>Receptor binding assays with botanical extracts have revealed direct interactions of leaf extracts of kava (which appear to be more active than root extracts) with the <a href="/wiki/GABA" title="GABA">GABA</a> (i.e., main) binding site of the <a href="/wiki/GABAA" class="mw-redirect" title="GABAA">GABA<sub>A</sub></a> receptor, the <a href="/wiki/D2_receptor" class="mw-redirect" title="D2 receptor">D<sub>2</sub> receptor</a>, the <a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-</a> and <a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid receptors</a>, and the <a href="/wiki/H1_receptor" class="mw-redirect" title="H1 receptor">H<sub>1</sub></a> and <a href="/wiki/H2_receptor" class="mw-redirect" title="H2 receptor">H<sub>2</sub> receptors</a>.<sup id="cite_ref-pmid11458444_36-0" class="reference"><a href="#cite_note-pmid11458444-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DasguptaHammett-Stabler2011_37-0" class="reference"><a href="#cite_note-DasguptaHammett-Stabler2011-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Weak interaction with the <a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">5-HT<sub>6</sub></a> and <a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">5-HT<sub>7</sub> receptors</a> and the <a href="/wiki/Benzodiazepine_site" class="mw-redirect" title="Benzodiazepine site">benzodiazepine site</a> of the GABA<sub>A</sub> receptor was also observed.<sup id="cite_ref-pmid11458444_36-1" class="reference"><a href="#cite_note-pmid11458444-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p><p>Potentiation of GABA<sub>A</sub> receptor activity may underlie the <a href="/wiki/Anxiolytic" title="Anxiolytic">anxiolytic</a> effects of kava, while elevation of dopamine levels in the nucleus accumbens likely underlie the moderately <a href="/wiki/Psychotropic" class="mw-redirect" title="Psychotropic">psychotropic</a> effects the plant can produce. Changes in the activity of 5-HT neurons could explain the sleep-inducing action.<sup id="cite_ref-pmid9829291_38-0" class="reference"><a href="#cite_note-pmid9829291-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> However, failure of the GABA<sub>A</sub> receptor inhibitor <a href="/wiki/Flumazenil" title="Flumazenil">flumazenil</a> to reverse the anxiolytic effects of kava in mice suggests that <a href="/wiki/Benzodiazepine" title="Benzodiazepine">benzodiazepine</a>-like effects are not contributing to the pharmacological profile of kava extracts.<sup id="cite_ref-pmid12845414_39-0" class="reference"><a href="#cite_note-pmid12845414-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p><p>Heavy, long-term use of kava has been found to be free of association with reduced ability in <a href="/wiki/Saccade" title="Saccade">saccade</a> and <a href="/wiki/Cognitive_test" title="Cognitive test">cognitive tests</a>, but has been associated with elevated liver enzymes.<sup id="cite_ref-pmid12589393_40-0" class="reference"><a href="#cite_note-pmid12589393-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Detection">Detection</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=11" title="Edit section: Detection"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Recent usage of kava has been documented in forensic investigations by quantitation of kavain in blood specimens. The principal urinary metabolite, conjugated 4'-OH-kavain, is generally detectable for up to 48 hours.<sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Preparations">Preparations</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=12" title="Edit section: Preparations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Kava_fiji.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/51/Kava_fiji.jpg/220px-Kava_fiji.jpg" decoding="async" width="220" height="153" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/51/Kava_fiji.jpg/330px-Kava_fiji.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/51/Kava_fiji.jpg/440px-Kava_fiji.jpg 2x" data-file-width="445" data-file-height="310" /></a><figcaption>Kava root drying in <a href="/wiki/Lovoni" title="Lovoni">Lovoni</a> village, <a href="/wiki/Ovalau_(Fiji)" class="mw-redirect" title="Ovalau (Fiji)">Ovalau</a>, <a href="/wiki/Fiji" title="Fiji">Fiji</a> (2005)</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Traditional_preparation">Traditional preparation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=13" title="Edit section: Traditional preparation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kava is consumed in various ways throughout the <a href="/wiki/Pacific_Ocean" title="Pacific Ocean">Pacific Ocean</a> cultures of <a href="/wiki/Polynesia" title="Polynesia">Polynesia</a>, <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a>, <a href="/wiki/Melanesia" title="Melanesia">Melanesia</a>, and some parts of <a href="/wiki/Micronesia" title="Micronesia">Micronesia</a> and <a href="/wiki/Australia" title="Australia">Australia</a>. Traditionally, it is prepared by either chewing, grinding, or pounding the roots of the kava plant. Grinding is done by hand against a cone-shaped block of dead <a href="/wiki/Coral" title="Coral">coral</a>; the hand forms a <a href="/wiki/Mortar_and_pestle" title="Mortar and pestle">mortar</a> and the coral a <a href="/wiki/Pestle" class="mw-redirect" title="Pestle">pestle</a>. The ground root/bark is combined with only a little water, as the fresh root releases moisture during grinding. Pounding is done in a large stone with a small log. The product is then added to cold water and consumed as quickly as possible. </p><p>The extract is an <a href="/wiki/Emulsion" title="Emulsion">emulsion</a> of kavalactone droplets in starch. The taste is slightly pungent, while the distinctive aroma depends on whether it was prepared from dry or fresh plant, and on the variety. The colour is grey to tan to opaque greenish. </p><p>Kava prepared as described above is much more potent than processed kava. Chewing produces the strongest effect because it produces the finest particles. Fresh, undried kava produces a stronger beverage than dry kava. The strength also depends on the species and techniques of cultivation. </p><p>In Vanuatu, a strong kava drink is normally followed by a hot meal or tea. The meal traditionally follows some time after the drink so that the <a href="/wiki/Psychoactive" class="mw-redirect" title="Psychoactive">psychoactives</a> are absorbed into the bloodstream more quickly. Traditionally, no flavoring is added. </p><p>In Papua New Guinea, the locals in Madang province refer to their kava as <i>waild koniak</i> ("wild cognac" in English). </p> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Fijian_kava_ceremony.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Fijian_kava_ceremony.jpg/260px-Fijian_kava_ceremony.jpg" decoding="async" width="260" height="163" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Fijian_kava_ceremony.jpg/390px-Fijian_kava_ceremony.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b8/Fijian_kava_ceremony.jpg/520px-Fijian_kava_ceremony.jpg 2x" data-file-width="3557" data-file-height="2234" /></a><figcaption>Fijian kava ceremony being performed for tourists (2015). Traditionally, kava grog is drunk from the shorn half-shell of a coconut, called a <i>bilo</i>.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p><span class="anchor" id="Grog"></span><a href="/wiki/Fijians" title="Fijians">Fijians</a> commonly share a drink called <b>grog</b>, made by pounding sun-dried kava root into a fine powder, straining and mixing it with cold water. Traditionally, grog is drunk from the shorn half-shell of a coconut, called a <i>bilo</i>. Grog is very popular in <a href="/wiki/Fiji" title="Fiji">Fiji</a>, especially among young men, and often brings people together for storytelling and socializing. Drinking grog for a few hours brings a numbing and relaxing effect to the drinker; grog also numbs the tongue, and grog drinking typically is followed by a "chaser" or sweet or spicy snack to follow a <i>bilo</i>. </p> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Kava_vanuatu.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/en/thumb/9/95/Kava_vanuatu.jpg/220px-Kava_vanuatu.jpg" decoding="async" width="220" height="136" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/95/Kava_vanuatu.jpg/330px-Kava_vanuatu.jpg 1.5x, //upload.wikimedia.org/wikipedia/en/9/95/Kava_vanuatu.jpg 2x" data-file-width="400" data-file-height="247" /></a><figcaption>Kava root being prepared for consumption in Asanvari village on <a href="/wiki/Maewo" title="Maewo">Maewo</a> Island, <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a> (2006).</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Supplements_and_pharmaceutical_preparations">Supplements and pharmaceutical preparations</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=14" title="Edit section: Supplements and pharmaceutical preparations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Water extraction is the traditional method for preparation of the plant. <a href="/wiki/Pharmaceutical" class="mw-redirect" title="Pharmaceutical">Pharmaceutical</a> and <a href="/wiki/Herbal_supplement" class="mw-redirect" title="Herbal supplement">herbal supplement</a> companies extract kavalactones from the kava plant using solvents such as <a href="/wiki/Supercritical_carbon_dioxide" title="Supercritical carbon dioxide">supercritical carbon dioxide</a>,<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Acetone" title="Acetone">acetone</a>, and <a href="/wiki/Ethanol" title="Ethanol">ethanol</a> to produce pills standardized with between 30% and 90% kavalactones.<sup id="cite_ref-teschke2011_26-1" class="reference"><a href="#cite_note-teschke2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Concerns">Concerns</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=15" title="Edit section: Concerns"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Numerous scholars<sup id="cite_ref-teschke16_44-0" class="reference"><a href="#cite_note-teschke16-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> and regulatory bodies<sup id="cite_ref-:2_45-0" class="reference"><a href="#cite_note-:2-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:7_46-0" class="reference"><a href="#cite_note-:7-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> have raised concerns over the safety profile of such products. </p><p>One group of scholars say that organic solvents introduce compounds that may affect the liver into the standardized product; these compounds are not extracted by water and are consequently largely absent from kava prepared with water.<sup id="cite_ref-:5_47-0" class="reference"><a href="#cite_note-:5-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> For instance, when compared with water extraction, organic solvents extract vastly larger amounts of flavokavains, compounds associated with adverse reactions to kava that are present in very low concentrations in noble kava, but significant in non-noble.<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kuchta_1647–1653_10-4" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Also, "chemical solvents used do not extract the same compounds as the natural water extracts in traditional use. The extraction process may exclude important modifying constituents soluble only in water".<sup id="cite_ref-:5_47-1" class="reference"><a href="#cite_note-:5-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> In particular, it has been noted that, unlike traditional water-based preparations, products obtained with the use of organic solvents do not contain <a href="/wiki/Glutathione" title="Glutathione">glutathione</a>, an important liver-protecting compound.<sup id="cite_ref-:6_49-0" class="reference"><a href="#cite_note-:6-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> Another group of researchers noted: "The extraction process (aqueous vs. acetone in the two types of preparations) is responsible for the difference in toxicity as extraction of glutathione in addition to the kava lactones is important to provide protection against hepatotoxicity".<sup id="cite_ref-:6_49-1" class="reference"><a href="#cite_note-:6-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> </p><p>It has also been argued that kavalactone extracts have often been made from low-quality plant material, including the toxic aerial parts of the plant that contain the hepatotoxic alkaloid <a href="/wiki/Pipermethystine" title="Pipermethystine">Pipermethystine</a>, non-noble kava varieties, or plants affected by mold — which, in light of the chemical solvents' ability to extract far greater amounts of the potentially toxic compounds than water, makes them particularly problematic. </p><p>In the context of these concerns, the <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> advises against the consumption of ethanolic and acetonic kavalactone extracts, and says that "products should be developed from water-based suspensions of kava".<sup id="cite_ref-:7_46-1" class="reference"><a href="#cite_note-:7-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> The government of Australia prohibits the sales of such kavalactone extracts, and only permits the sale of kava products in their natural form or produced with cold water.<sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Kava_culture">Kava culture</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=16" title="Edit section: Kava culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Kava.JPG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/be/Kava.JPG/220px-Kava.JPG" decoding="async" width="220" height="145" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/b/be/Kava.JPG 1.5x" data-file-width="320" data-file-height="211" /></a><figcaption>A sign showing a "Kava licence area" at <a href="/wiki/Yirrkala" title="Yirrkala">Yirrkala</a>, in the <a href="/wiki/Northern_Territory" title="Northern Territory">Northern Territory</a> of <a href="/wiki/Australia" title="Australia">Australia</a>.</figcaption></figure> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Kava_culture" title="Kava culture">Kava culture</a></div> <p>Kava is used for medicinal, religious, political, cultural, and social purposes throughout the Pacific. These cultures have a great respect for the plant and place a high importance on it. In Fiji, for example, a formal <i>yaqona</i> (kava) ceremony will often accompany important social, political, or religious functions, usually involving a ritual presentation of the bundled roots as a <i>sevusevu</i> (gift) and drinking of the <i>yaqona</i> itself.<sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> Due to the importance of kava in religious rituals and the seemingly (from the Western point of view) unhygienic preparation method, its consumption was discouraged or even banned by Christian missionaries.<sup id="cite_ref-:1_6-7" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Kava_bars">Kava bars</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=17" title="Edit section: Kava bars"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Nakamal" title="Nakamal">Nakamal</a></div> <p>With kava's increasing popularity, bars serving the plant in its liquid state are beginning to open up outside of the South Pacific.<sup id="cite_ref-Kuchta_1647–1653_10-5" class="reference"><a href="#cite_note-Kuchta_1647–1653-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-53" class="reference"><a href="#cite_note-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup> </p><p>While some bars have been committed to only serving the traditional forms and types of kava, other establishments have been accused of serving non-traditionally consumed non-noble kava varieties, which are cheaper but far more likely to cause unpleasant effects and adverse reactions, or of serving kava with other substances, including <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">alcohol</a>.<sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Effects_of_consumption">Effects of consumption</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=18" title="Edit section: Effects of consumption"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The nature of effects will largely depend on the cultivar of the kava plant and the form of its consumption.<sup id="cite_ref-:3_55-0" class="reference"><a href="#cite_note-:3-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> Traditionally, only noble kava cultivars have been consumed, as they are accepted as safe and produce desired effects.<sup id="cite_ref-Lebot_554–560_56-0" class="reference"><a href="#cite_note-Lebot_554–560-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup> The specific effects of various noble kavas depend on various factors, such as the cultivar used (and the related specific composition of kavalactones), age of the plant, and method of consumption.<sup id="cite_ref-:3_55-1" class="reference"><a href="#cite_note-:3-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> However, it can be stated that in general, noble kava produces a state of calmness, relaxation, and well-being without diminishing cognitive performance.<sup id="cite_ref-:1_6-8" class="reference"><a href="#cite_note-:1-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup> Kava may produce an initial talkative period, followed by muscle relaxation and eventual sleepiness.<sup id="cite_ref-59" class="reference"><a href="#cite_note-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup> </p><p>As noted in one of the earliest Western publications on kava (1886): "A well prepared Kava potion drunk in small quantities produces only pleasant changes in behavior. It is therefore a slightly stimulating drink which helps relieve great fatigue. It relaxes the body after strenuous efforts, clarifies the mind and sharpens the mental faculties".<sup id="cite_ref-60" class="reference"><a href="#cite_note-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup> </p><p>Despite its psychoactive effects, kava is not considered to be physically addictive and its use does not lead to dependency.<sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Toxicity,_safety,_and_potential_side_effects"><span id="Toxicity.2C_safety.2C_and_potential_side_effects"></span>Toxicity, safety, and potential side effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=19" title="Edit section: Toxicity, safety, and potential side effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="General_observations">General observations</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=20" title="Edit section: General observations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There is limited safety information available on the effects of kava consumption, but in general, moderate consumption appears unlikely to be harmful, while there is evidence of harm from heavy use.<sup id="cite_ref-fao-who_9-2" class="reference"><a href="#cite_note-fao-who-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Effects_on_the_liver">Effects on the liver</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=21" title="Edit section: Effects on the liver"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There is published evidence of the <a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">hepatotoxicity</a> of kava extracts, and concerns about this led to kava being omitted from the <a href="/wiki/US_Pharmacopeia" class="mw-redirect" title="US Pharmacopeia">US Pharmacopeia</a>.<sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Other_adverse_reactions">Other adverse reactions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=22" title="Edit section: Other adverse reactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Adverse reactions may result from the poor quality of kava raw material used in the manufacturing of various kava products.<sup id="cite_ref-teschke2011_26-2" class="reference"><a href="#cite_note-teschke2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-drugs_33-1" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_64-0" class="reference"><a href="#cite_note-:4-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-teschke16_44-1" class="reference"><a href="#cite_note-teschke16-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> In addition to the potential for hepatotoxicity, adverse reactions from chronic use may include visual impairment, rashes or dermatitis, seizures, weight loss, and malnutrition, but there is only limited high-quality research on these possible effects.<sup id="cite_ref-fao-who_9-3" class="reference"><a href="#cite_note-fao-who-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-drugs_33-2" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>On the basis of research findings and long history of safe use across the South Pacific, experts recommend using water-based extractions of high-quality peeled rhizome and roots of the noble kava cultivars to minimize the potential of adverse reactions to chronic use.<sup id="cite_ref-fao-who_9-4" class="reference"><a href="#cite_note-fao-who-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-teschke2011_26-3" class="reference"><a href="#cite_note-teschke2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Potential_interactions">Potential interactions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=23" title="Edit section: Potential interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Several adverse interactions with drugs have been documented, both prescription and nonprescription — including, but not limited to, <a href="/wiki/Anticonvulsants" class="mw-redirect" title="Anticonvulsants">anticonvulsants</a>, alcohol, <a href="/wiki/Anxiolytics" class="mw-redirect" title="Anxiolytics">anxiolytics</a> (central nervous system depressants such as <a href="/wiki/Benzodiazepines" class="mw-redirect" title="Benzodiazepines">benzodiazepines</a>), <a href="/wiki/Antipsychotics" class="mw-redirect" title="Antipsychotics">antipsychotics</a>, <a href="/wiki/Levodopa" title="Levodopa">levodopa</a>, diuretics, and drugs metabolized by <a href="/wiki/Cytochrome_P450" title="Cytochrome P450">CYP450</a> in the liver.<sup id="cite_ref-drugs_33-3" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>A few notable potential drug interactions are, but are not limited to: </p> <ul><li>Alcohol: It has been reported that combined use of alcohol and kava extract can have additive sedative effects.<sup id="cite_ref-drugs_33-4" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-65" class="reference"><a href="#cite_note-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup> Regarding cognitive function, kava has been shown to have additive cognitive impairments while taken with alcohol when compared to taking placebo and alcohol alone.<sup id="cite_ref-ReferenceA_66-0" class="reference"><a href="#cite_note-ReferenceA-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup></li> <li>Anxiolytics (CNS depressants such as benzodiazepines and barbiturates): Kava may have potential additive CNS depressant effects (such as sedation and anxiolytic effects) with <a href="/wiki/Benzodiazepines" class="mw-redirect" title="Benzodiazepines">benzodiazepines</a> and <a href="/wiki/Barbiturates" class="mw-redirect" title="Barbiturates">barbiturates</a>.<sup id="cite_ref-drugs_33-5" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReferenceA_66-1" class="reference"><a href="#cite_note-ReferenceA-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup> Kava taken in combination with <a href="/wiki/Alprazolam" title="Alprazolam">alprazolam</a> can cause a semicomatose state in humans.<sup id="cite_ref-67" class="reference"><a href="#cite_note-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a> <a href="/wiki/Agonist" title="Agonist">agonist</a> — <a href="/wiki/Levodopa" title="Levodopa">levodopa</a>: One of levodopa's chronic side effects that Parkinson's patients experience is the "on-off phenomenon" of motor fluctuations, where there will be periods of oscillations between "on", where the patient experiences symptomatic relief, and "off", where the therapeutic effect wears off early.<sup id="cite_ref-68" class="reference"><a href="#cite_note-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup> When taking levodopa and kava together, it has been shown that there is an increased frequency of this "on-off phenomenon".<sup id="cite_ref-69" class="reference"><a href="#cite_note-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Kava_dermopathy">Kava dermopathy</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=24" title="Edit section: Kava dermopathy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Long-term and heavy kava consumption is associated with a reversible <a href="/wiki/Cutaneous_condition" class="mw-redirect" title="Cutaneous condition">skin condition</a> known as "kava dermopathy", or <i>kanikani</i> (in the <a href="/wiki/Fijian_language" title="Fijian language">Fijian language</a>), characterised by dry and scaly skin covering the palms of the hands, soles of the feet, and back.<sup id="cite_ref-drugs_33-6" class="reference"><a href="#cite_note-drugs-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-70" class="reference"><a href="#cite_note-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Norton_89–97_71-0" class="reference"><a href="#cite_note-Norton_89–97-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup> The first symptom to appear is usually dry, peeling skin; some Pacific Islanders deliberately consume large quantities of kava for several weeks in order to get the peeling effect, resulting in a layer of new skin.<sup id="cite_ref-72" class="reference"><a href="#cite_note-72"><span class="cite-bracket">[</span>72<span class="cite-bracket">]</span></a></sup> These effects appeared at consumption levels between 31 grams (1.1 oz) to 440 grams (0.97 lb) a week of kava powder. Despite numerous studies, the mechanism that causes kava dermopathy is poorly understood "but may relate to interference with cholesterol metabolism".<sup id="cite_ref-Norton_89–97_71-1" class="reference"><a href="#cite_note-Norton_89–97-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup> The condition is easily treatable with abstinence or lowering of kava intake as the skin appears to be returning to its normal state within a couple of weeks of reduced or no kava use.<sup id="cite_ref-Norton_89–97_71-2" class="reference"><a href="#cite_note-Norton_89–97-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup> Kava dermopathy should not be confused with rare instances of allergic reactions to kava that are usually characterised by itchy rash or puffy face.<sup id="cite_ref-73" class="reference"><a href="#cite_note-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=25" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kava is under preliminary research for its potential <a href="/wiki/Psychoactive" class="mw-redirect" title="Psychoactive">psychoactive</a><sup id="cite_ref-pmid21073405_30-3" class="reference"><a href="#cite_note-pmid21073405-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> — primarily <a href="/wiki/Anxiolytic" title="Anxiolytic">anxiolytic</a> — sleep-inducing, and sleep-enhancing properties.<sup id="cite_ref-74" class="reference"><a href="#cite_note-74"><span class="cite-bracket">[</span>74<span class="cite-bracket">]</span></a></sup> Preliminary analysis of kava effects in people with short-term <a href="/wiki/Anxiety_disorder" title="Anxiety disorder">anxiety disorders</a> indicated a small level of improvement.<sup id="cite_ref-pittler_8-1" class="reference"><a href="#cite_note-pittler-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Traditional_medicine">Traditional medicine</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=26" title="Edit section: Traditional medicine"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Yaqona-bundle-Fiji-2010.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/28/Yaqona-bundle-Fiji-2010.jpg/220px-Yaqona-bundle-Fiji-2010.jpg" decoding="async" width="220" height="143" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/28/Yaqona-bundle-Fiji-2010.jpg/330px-Yaqona-bundle-Fiji-2010.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/28/Yaqona-bundle-Fiji-2010.jpg/440px-Yaqona-bundle-Fiji-2010.jpg 2x" data-file-width="2259" data-file-height="1469" /></a><figcaption>A traditional Fijian yaqona bundle of roots</figcaption></figure> <p>Over centuries, kava has been used in the <a href="/wiki/Traditional_medicine" title="Traditional medicine">traditional medicine</a> of the South <a href="/wiki/Pacific_Islands" class="mw-redirect" title="Pacific Islands">Pacific Islands</a> for <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> and peripheral effects.<sup id="cite_ref-Showman_56–67_75-0" class="reference"><a href="#cite_note-Showman_56–67-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup> As noted in one literature review: "Peripherally, kava is indicated in traditional Pacific medicine for urogenital conditions (<a href="/wiki/Gonorrhea" title="Gonorrhea">gonorrhea</a> infections, chronic <a href="/wiki/Urinary_tract_infection" title="Urinary tract infection">cystitis</a>, difficulty urinating), reproductive and women's health (...), gastrointestinal upsets, respiratory ailments (<a href="/wiki/Asthma" title="Asthma">asthma</a>, coughs, and <a href="/wiki/Tuberculosis" title="Tuberculosis">tuberculosis</a>), skin diseases and topical wounds, and as an <a href="/wiki/Analgesic" title="Analgesic">analgesic</a>, with significant subtlety and nuance attending the precise strain, plant component (leaf, stem, root) and preparative method to be used".<sup id="cite_ref-Showman_56–67_75-1" class="reference"><a href="#cite_note-Showman_56–67-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Regulation">Regulation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=27" title="Edit section: Regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kava remains legal in most countries. Regulations often treat it as a food or <a href="/wiki/Dietary_supplement" title="Dietary supplement">dietary supplement</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Australia">Australia</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=28" title="Edit section: Australia"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In Australia, the supply of kava is regulated through the National Code of Kava Management.<sup id="cite_ref-ANZFSC_76-0" class="reference"><a href="#cite_note-ANZFSC-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> Travellers to Australia are allowed to bring up to 4 kg of kava in their baggage, provided they are at least 18 years old and the kava is in root or dried form. Commercial import of larger quantities is allowed, under licence for medical or scientific purposes. These restrictions were introduced in 2007 after concern about abuse of kava in indigenous communities. Initially, the import limit was 2 kg per person; it was raised to 4 kg in December 2019, and a pilot program allowing for commercial importation was implemented on 1 December 2021.<sup id="cite_ref-77" class="reference"><a href="#cite_note-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-78" class="reference"><a href="#cite_note-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup> </p><p>The Australian <a href="/wiki/Therapeutic_Goods_Administration" title="Therapeutic Goods Administration">Therapeutic Goods Administration</a> has recommended no more than 250 mg of kavalactones be taken in a 24‑hour period.<sup id="cite_ref-79" class="reference"><a href="#cite_note-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup> </p><p>Kava possession is limited to 2 kg per adult in the <a href="/wiki/Northern_Territory" title="Northern Territory">Northern Territory</a>.<sup id="cite_ref-80" class="reference"><a href="#cite_note-80"><span class="cite-bracket">[</span>80<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-81" class="reference"><a href="#cite_note-81"><span class="cite-bracket">[</span>81<span class="cite-bracket">]</span></a></sup> While it was previously banned in <a href="/wiki/Western_Australia" title="Western Australia">Western Australia</a> in the 2000s, the Western Australian Health Department announced the lifting of the ban in February 2017, bringing Western Australia "into line with other States" where it has always remained legal, albeit closely regulated.<sup id="cite_ref-82" class="reference"><a href="#cite_note-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Europe">Europe</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=29" title="Edit section: Europe"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Following discussions on the safety of certain pharmaceutical products derived from kava and sold in Germany, the EU imposed a temporary ban on imports of kava-based pharmaceutical products in 2002. The sale of kava plant became regulated in <a href="/wiki/Switzerland" title="Switzerland">Switzerland</a>, <a href="/wiki/France" title="France">France</a>, and in prepared form in the <a href="/wiki/Netherlands" title="Netherlands">Netherlands</a>.<sup id="cite_ref-83" class="reference"><a href="#cite_note-83"><span class="cite-bracket">[</span>83<span class="cite-bracket">]</span></a></sup> Some Pacific island states which had been benefiting from the export of kava to the pharmaceutical companies have attempted to overturn the EU ban on kava-based pharmaceutical products by invoking international trade agreements at the <a href="/wiki/WTO" class="mw-redirect" title="WTO">WTO</a>: <a href="/wiki/Fiji" title="Fiji">Fiji</a>, <a href="/wiki/Samoa" title="Samoa">Samoa</a>, <a href="/wiki/Tonga" title="Tonga">Tonga</a>, and <a href="/wiki/Vanuatu" title="Vanuatu">Vanuatu</a> argued that the ban was imposed with insufficient evidence.<sup id="cite_ref-84" class="reference"><a href="#cite_note-84"><span class="cite-bracket">[</span>84<span class="cite-bracket">]</span></a></sup> The pressure prompted <a href="/wiki/Germany" title="Germany">Germany</a> to reconsider the evidence base for banning kava-based pharmaceutical products.<sup id="cite_ref-85" class="reference"><a href="#cite_note-85"><span class="cite-bracket">[</span>85<span class="cite-bracket">]</span></a></sup> On 10 June 2014, the German Administrative Court overturned the 2002 ban, making selling kava as a medicine legal (personal possession of kava has never been illegal), albeit strictly regulated. In Germany, kava-based pharmaceutical preparations are currently prescription drugs. Furthermore, patient and professional information brochures have been redesigned to warn about potential side effects.<sup id="cite_ref-86" class="reference"><a href="#cite_note-86"><span class="cite-bracket">[</span>86<span class="cite-bracket">]</span></a></sup> These strict measures have been opposed by some of the leading kava scientists. In early 2016, a court case was filed against the Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM/German Federal Institute for Drugs and Medical Devices), arguing that the new regulatory regime is too strict and not justified.<sup id="cite_ref-87" class="reference"><a href="#cite_note-87"><span class="cite-bracket">[</span>87<span class="cite-bracket">]</span></a></sup> </p><p>In the <a href="/wiki/United_Kingdom" title="United Kingdom">United Kingdom</a>, it is a criminal offence to sell, supply, or import any medicinal product containing kava for human consumption.<sup id="cite_ref-88" class="reference"><a href="#cite_note-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup> It is legal to possess kava for personal use or to import it for purposes other than human consumption (e.g., for animals). </p><p>Until August 2018, Poland was the only EU country with an "outright ban on kava" and where the mere possession of kava was prohibited and may have resulted in a prison sentence.<sup id="cite_ref-89" class="reference"><a href="#cite_note-89"><span class="cite-bracket">[</span>89<span class="cite-bracket">]</span></a></sup> Under the new legislation, kava is no longer listed among prohibited substances and it is therefore legal to possess, import, and consume the plant,<sup id="cite_ref-90" class="reference"><a href="#cite_note-90"><span class="cite-bracket">[</span>90<span class="cite-bracket">]</span></a></sup> but it remains illegal to sell it within Poland for the purpose of human consumption.<sup id="cite_ref-91" class="reference"><a href="#cite_note-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup> </p><p>In the Netherlands, for unknown reasons, the ban was never lifted, and it is still prohibited to prepare, manufacture, or trade kava or goods containing kava.<sup id="cite_ref-92" class="reference"><a href="#cite_note-92"><span class="cite-bracket">[</span>92<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="New_Zealand">New Zealand</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=30" title="Edit section: New Zealand"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>When used traditionally, kava is regulated as a food under the Food Standards Code. Kava may also be used as an herbal remedy, where it is currently regulated by the Dietary Supplements Regulations. Only traditionally consumed forms and parts of the kava plant (i.e., pure roots of the kava plant, water extractions prepared from these roots) can legally be sold as food or dietary supplements in New Zealand. The aerial parts of the plant (growing up and out of the ground), unlike the roots, contain relatively small amounts of kavalactones; instead, they contain a mildly toxic alkaloid, pipermethysticine.<sup id="cite_ref-:2_45-1" class="reference"><a href="#cite_note-:2-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> While not normally consumed, the sale of aerial plant sections and non-water based extract (such as CO<sub style="font-size: 80%;vertical-align: -0.35em">2</sub>, acetonic, or ethanol extractions) is prohibited for the purpose of human consumption (but can be sold as an ingredient in cosmetics or other products not intended for human consumption).<sup id="cite_ref-93" class="reference"><a href="#cite_note-93"><span class="cite-bracket">[</span>93<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-94" class="reference"><a href="#cite_note-94"><span class="cite-bracket">[</span>94<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="North_America">North America</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=31" title="Edit section: North America"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In 2002, <a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a> issued an order prohibiting the sale of any product containing kava.<sup id="cite_ref-95" class="reference"><a href="#cite_note-95"><span class="cite-bracket">[</span>95<span class="cite-bracket">]</span></a></sup> While the restrictions on kava were lifted in 2012,<sup id="cite_ref-96" class="reference"><a href="#cite_note-96"><span class="cite-bracket">[</span>96<span class="cite-bracket">]</span></a></sup> Health Canada lists five kava ingredients as of 2017.<sup id="cite_ref-97" class="reference"><a href="#cite_note-97"><span class="cite-bracket">[</span>97<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-98" class="reference"><a href="#cite_note-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup> </p><p>In 2002, the U.S. <a href="/wiki/Regulation_of_food_and_dietary_supplements_by_the_U.S._Food_and_Drug_Administration" title="Regulation of food and dietary supplements by the U.S. Food and Drug Administration">Food and Drug Administration</a> issued a Consumer Advisory: "Kava-Containing Dietary Supplements May be Associated with Severe Liver Injury". No legal action was taken, and this advisory has since been archived.<sup id="cite_ref-99" class="reference"><a href="#cite_note-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Vanuatu">Vanuatu</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=32" title="Edit section: Vanuatu"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The Pacific island-state of Vanuatu has passed legislation to regulate the quality of its kava exports. Vanuatu prohibits the export or consumption of non-noble kava varieties or the parts of the plant that are unsuitable for consumption (such as leaves and stems).<sup id="cite_ref-100" class="reference"><a href="#cite_note-100"><span class="cite-bracket">[</span>100<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=33" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/List_of_herbs_with_known_adverse_effects" title="List of herbs with known adverse effects">List of herbs with known adverse effects</a></li> <li><a href="/wiki/Alcohol_and_Drugs_History_Society" title="Alcohol and Drugs History Society">Alcohol and Drugs History Society</a></li> <li><a href="/wiki/Betel" title="Betel">Betel</a></li> <li><a href="/wiki/Domesticated_plants_and_animals_of_Austronesia" title="Domesticated plants and animals of Austronesia">Domesticated plants and animals of Austronesia</a></li> <li><a href="/wiki/Kava_culture" title="Kava culture">Kava culture</a></li> <li><a href="/wiki/Nakamal" title="Nakamal">Nakamal</a></li> <li><a href="/wiki/Paan" class="mw-redirect" title="Paan">Paan</a></li> <li><a href="/wiki/Samoa_%27ava_ceremony" class="mw-redirect" title="Samoa 'ava ceremony">Samoa 'ava ceremony</a></li> <li><a href="/wiki/Samoan_plant_names" class="mw-redirect" title="Samoan plant names">Samoan plant names</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=34" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-mwd-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-mwd_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-mwd_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.merriam-webster.com/dictionary/kava">"Kava"</a>. Merriam–Webster Online Dictionary. 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Kava&rft.pub=Merriam%E2%80%93Webster+Online+Dictionary&rft.date=2018&rft_id=https%3A%2F%2Fwww.merriam-webster.com%2Fdictionary%2Fkava&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://wehewehe.org/gsdl2.85/cgi-bin/hdict?a=d&d=D1669">"Nā Puke Wehewehe ʻŌlelo Hawaiʻi"</a>. <i>wehewehe.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">22 December</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=wehewehe.org&rft.atitle=N%C4%81+Puke+Wehewehe+%CA%BB%C5%8Clelo+Hawai%CA%BBi&rft_id=http%3A%2F%2Fwehewehe.org%2Fgsdl2.85%2Fcgi-bin%2Fhdict%3Fa%3Dd%26d%3DD1669&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20180610162905/http://www.fijiembassy.be/index.php?page_in=yaqona">"Embassy of the Republic of Fiji"</a>. <i>www.fijiembassy.be</i>. Archived from <a rel="nofollow" class="external text" href="http://www.fijiembassy.be/index.php?page_in=yaqona">the original</a> on 10 June 2018<span class="reference-accessdate">. Retrieved <span class="nowrap">22 December</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.fijiembassy.be&rft.atitle=Embassy+of+the+Republic+of+Fiji&rft_id=http%3A%2F%2Fwww.fijiembassy.be%2Findex.php%3Fpage_in%3Dyaqona&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text">Balick, Michael J. and Leem, Roberta (2002) <a rel="nofollow" class="external text" href="http://sciweb.nybg.org/science2/pdfs/mb/Kava.pdf"><i>Traditional use of sakau (kava) in Pohnpei: lessons for integrative medicine</i></a> Alternative Therapies, Vol. 8, No.4. p. 96</span> </li> <li id="cite_note-Lebot1992-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-Lebot1992_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Lebot1992_5-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLebotMerlinLindstrom1992" class="citation book cs1">Lebot V, Merlin M, Lindstrom L (23 December 1992). <i>Kava</i>. Yale University Press. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2307%2Fj.ctt211qwxb">10.2307/j.ctt211qwxb</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-300-23898-3" title="Special:BookSources/978-0-300-23898-3"><bdi>978-0-300-23898-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Kava&rft.pub=Yale+University+Press&rft.date=1992-12-23&rft_id=info%3Adoi%2F10.2307%2Fj.ctt211qwxb&rft.isbn=978-0-300-23898-3&rft.aulast=Lebot&rft.aufirst=Vincent&rft.au=Merlin%2C+Mark&rft.au=Lindstrom%2C+Lamont&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-:1-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-:1_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:1_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-:1_6-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-:1_6-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-:1_6-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-:1_6-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-:1_6-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-:1_6-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-:1_6-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLebotMerlinLindstrom1997" class="citation book cs1">Lebot V, Merlin M, Lindstrom L (1997). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=wxTrQOP36NsC&pg=PA37"><i>Kava: The Pacific Elixir: The Definitive Guide to Its Ethnobotany, History, and Chemistry</i></a>. 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Health Canada. 26 May 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">3 July</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.hc-sc.gc.ca&rft.atitle=Listing+of+Drugs+Currently+Regulated+as+New+Drugs+%28The+New+Drugs+List%29&rft.date=2016-05-26&rft_id=http%3A%2F%2Fwww.hc-sc.gc.ca%2Fdhp-mps%2Fprodpharma%2Fapplic-demande%2Fguide-ld%2Fnewdrug-drognouv%2Fndrugs_ndrogue-eng.php&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-97"><span class="mw-cite-backlink"><b><a href="#cite_ref-97">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.healthlinkbc.ca/health-topics/kava">"Kava"</a>. HealthLink BC, Government of British Columbia. 23 September 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">3 March</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Kava&rft.pub=HealthLink+BC%2C+Government+of+British+Columbia&rft.date=2021-09-23&rft_id=https%3A%2F%2Fwww.healthlinkbc.ca%2Fhealth-topics%2Fkava&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-98"><span class="mw-cite-backlink"><b><a href="#cite_ref-98">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20220811202841/http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredsReq.do?srchRchTxt=kava&srchRchRole=-1&mthd=Search&lang=eng">"Ingredients - Kava"</a>. Health Canada. 2017. Archived from <a rel="nofollow" class="external text" href="http://webprod.hc-sc.gc.ca/nhpid-bdipsn/ingredsReq.do?srchRchTxt=kava&srchRchRole=-1&mthd=Search&lang=eng">the original</a> on 11 August 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">1 July</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Ingredients+-+Kava&rft.pub=Health+Canada&rft.date=2017&rft_id=http%3A%2F%2Fwebprod.hc-sc.gc.ca%2Fnhpid-bdipsn%2FingredsReq.do%3FsrchRchTxt%3Dkava%26srchRchRole%3D-1%26mthd%3DSearch%26lang%3Deng&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-99"><span class="mw-cite-backlink"><b><a href="#cite_ref-99">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090603082809/https://www.fda.gov/Food/ResourcesForYou/Consumers/ucm085482.htm">"Consumer Advisory: Kava-Containing Dietary Supplements May be Associated with Severe Liver Injury"</a>. US Food and Drug Administration. 25 March 2002. Archived from <a rel="nofollow" class="external text" href="https://www.fda.gov/Food/ResourcesForYou/Consumers/ucm085482.htm">the original</a> on 3 June 2009<span class="reference-accessdate">. Retrieved <span class="nowrap">28 June</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Consumer+Advisory%3A+Kava-Containing+Dietary+Supplements+May+be+Associated+with+Severe+Liver+Injury&rft.pub=US+Food+and+Drug+Administration&rft.date=2002-03-25&rft_id=https%3A%2F%2Fwww.fda.gov%2FFood%2FResourcesForYou%2FConsumers%2Fucm085482.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> <li id="cite_note-100"><span class="mw-cite-backlink"><b><a href="#cite_ref-100">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://faolex.fao.org/docs/html/van38473.htm">"Vanuatu - Legislation - Kava Act 2002"</a>. <i>faolex.fao.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2 July</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=faolex.fao.org&rft.atitle=Vanuatu+-+Legislation+-+Kava+Act+2002&rft_id=http%3A%2F%2Ffaolex.fao.org%2Fdocs%2Fhtml%2Fvan38473.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Kava&action=edit&section=35" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:var(--background-color-interactive-subtle,#f8f9fa);display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1;min-width:0}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-image"><span class="noviewer" typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/34px-Wikispecies-logo.svg.png" decoding="async" width="34" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/51px-Wikispecies-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/df/Wikispecies-logo.svg/68px-Wikispecies-logo.svg.png 2x" data-file-width="941" data-file-height="1103" /></span></span></div> <div class="side-box-text plainlist"><a href="/wiki/Wikispecies" title="Wikispecies">Wikispecies</a> has information related to <i><b><a href="https://species.wikimedia.org/wiki/Piper_methysticum" class="extiw" title="wikispecies:Piper methysticum">Piper methysticum</a></b></i>.</div></div> </div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1235681985"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1237033735"><div class="side-box side-box-right plainlinks sistersitebox"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"> <div class="side-box-flex"> <div class="side-box-image"><span class="noviewer" typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/38px-Wikisource-logo.svg.png" decoding="async" width="38" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/57px-Wikisource-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/76px-Wikisource-logo.svg.png 2x" data-file-width="410" data-file-height="430" /></span></span></div> <div class="side-box-text plainlist"><a href="/wiki/Wikisource" title="Wikisource">Wikisource</a> has the text of the <a href="/wiki/Encyclop%C3%A6dia_Britannica_Eleventh_Edition" title="Encyclopædia Britannica Eleventh Edition">1911 <i>Encyclopædia Britannica</i></a> article "<span style="font-weight:bold;"><a href="https://en.wikisource.org/wiki/1911_Encyclop%C3%A6dia_Britannica/Kava" class="extiw" title="wikisource:1911 Encyclopædia Britannica/Kava">Kava</a></span>".</div></div> </div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1973-01-01_2_page008.html">"UNODC - Bulletin on Narcotics: The narcotic pepper - The chemistry and pharmacology of Piper methysticum and related species"</a>. United Nations Office on Drugs and Crime. 1973. pp. Issue 2<span class="reference-accessdate">. Retrieved <span class="nowrap">19 February</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=UNODC+-+Bulletin+on+Narcotics%3A+The+narcotic+pepper+-+The+chemistry+and+pharmacology+of+Piper+methysticum+and+related+species&rft.pages=Issue+2&rft.pub=United+Nations+Office+on+Drugs+and+Crime&rft.date=1973&rft_id=http%3A%2F%2Fwww.unodc.org%2Funodc%2Fen%2Fdata-and-analysis%2Fbulletin%2Fbulletin_1973-01-01_2_page008.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20030901220234/http://www.spc.int/cis/kava.htm">Kava ban documents</a></li> <li><a rel="nofollow" class="external text" href="http://www.hear.org/species/piper_methysticum/"><i>Piper methysticum</i> information</a> from the Hawaiian Ecosystems at Risk project (<a rel="nofollow" class="external text" href="http://www.hear.org/">HEAR</a>)</li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation encyclopaedia cs1"><span class="cs1-ws-icon" title="s:Encyclopædia Britannica, Ninth Edition/Kava"><a class="external text" href="https://en.wikisource.org/wiki/Encyclop%C3%A6dia_Britannica,_Ninth_Edition/Kava">"Kava" </a></span>. <i><a href="/wiki/Encyclop%C3%A6dia_Britannica" title="Encyclopædia Britannica">Encyclopædia Britannica</a></i>. Vol. 14 (9th ed.). 1882.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Kava&rft.btitle=Encyclop%C3%A6dia+Britannica&rft.edition=9th&rft.date=1882&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKava" class="Z3988"></span></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul 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id="Kava" style="font-size:114%;margin:0 4em"><a class="mw-selflink selflink">Kava</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">History</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Kava</a></li> <li><a href="/wiki/Kava_culture" title="Kava culture">Kava culture</a></li> <li><a href="/wiki/Coconut_shell_cup" title="Coconut shell cup">Coconut shell cup</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Chemical composition</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Kavalactone" title="Kavalactone">Kavalactones</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Desmethoxyyangonin" title="Desmethoxyyangonin">Desmethoxyyangonin</a></li> <li><a href="/wiki/Dihydrokavain" title="Dihydrokavain">Dihydrokavain</a></li> <li><a href="/wiki/Dihydromethysticin" title="Dihydromethysticin">Dihydromethysticin</a></li> <li><a href="/wiki/Kavain" title="Kavain">Kavain</a></li> <li><a href="/wiki/Methysticin" title="Methysticin">Methysticin</a></li> <li><a href="/wiki/Yangonin" title="Yangonin">Yangonin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Flavokavain" title="Flavokavain">Flavokavains</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Flavokavain_A" title="Flavokavain A">Flavokavain A</a></li> <li><a href="/wiki/Flavokavain_B" title="Flavokavain B">Flavokavain B</a></li> <li><a href="/wiki/Flavokavain_C" title="Flavokavain C">Flavokavain C</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pipermethystine" title="Pipermethystine">Pipermethystine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Hypnotics/sedatives_(N05C)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Hypnotics_and_sedatives" title="Template:Hypnotics and sedatives"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Hypnotics_and_sedatives" title="Template talk:Hypnotics and sedatives"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Hypnotics_and_sedatives" title="Special:EditPage/Template:Hypnotics and sedatives"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hypnotics/sedatives_(N05C)" style="font-size:114%;margin:0 4em"><a href="/wiki/Hypnotic" title="Hypnotic">Hypnotics</a>/<a href="/wiki/Sedative" title="Sedative">sedatives</a> (<a href="/wiki/ATC_code_N05#N05C" title="ATC code N05">N05C</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GABAA_receptor" title="GABAA receptor">GABA<sub>A</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Alcohol_(chemistry)" title="Alcohol (chemistry)">Alcohols</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2M2B" class="mw-redirect" title="2M2B">2M2B</a></li> <li><a href="/wiki/Chloralodol" title="Chloralodol">Chloralodol</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Diethylpropanediol" class="mw-redirect" title="Diethylpropanediol">Diethylpropanediol</a></li> <li><a href="/wiki/Ethchlorvynol" title="Ethchlorvynol">Ethchlorvynol</a></li> <li><a href="/wiki/Methylpentynol" title="Methylpentynol">Methylpentynol</a></li> <li><a href="/wiki/2,2,2-Trichloroethanol" title="2,2,2-Trichloroethanol">Trichloroethanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Barbiturate" title="Barbiturate">Barbiturates</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allobarbital" title="Allobarbital">Allobarbital</a></li> <li><a href="/wiki/Amobarbital" title="Amobarbital">Amobarbital</a></li> <li><a href="/wiki/Aprobarbital" title="Aprobarbital">Aprobarbital</a></li> <li><a href="/wiki/Barbital" title="Barbital">Barbital</a></li> <li><a href="/wiki/Butabarbital" title="Butabarbital">Butabarbital</a></li> <li><a href="/wiki/Butobarbital" title="Butobarbital">Butobarbital</a></li> <li><a href="/wiki/Cyclobarbital" title="Cyclobarbital">Cyclobarbital</a></li> <li><a href="/wiki/Ethallobarbital" title="Ethallobarbital">Ethallobarbital</a></li> <li><a href="/wiki/Heptabarb" title="Heptabarb">Heptabarb</a></li> <li><a href="/wiki/Hexobarbital" title="Hexobarbital">Hexobarbital</a></li> <li><a href="/wiki/Mephobarbital" class="mw-redirect" title="Mephobarbital">Mephobarbital</a></li> <li><a href="/wiki/Methohexital" title="Methohexital">Methohexital</a></li> <li><a href="/wiki/Narcobarbital" title="Narcobarbital">Narcobarbital</a></li> <li><a href="/wiki/Pentobarbital" title="Pentobarbital">Pentobarbital</a></li> <li><a href="/wiki/Phenallymal" class="mw-redirect" title="Phenallymal">Phenallymal</a></li> <li><a href="/wiki/Phenobarbital" title="Phenobarbital">Phenobarbital</a></li> <li><a href="/wiki/Propylbarbital" title="Propylbarbital">Propylbarbital</a></li> <li><a href="/wiki/Proxibarbal" class="mw-redirect" title="Proxibarbal">Proxibarbal</a></li> <li><a href="/wiki/Reposal" title="Reposal">Reposal</a></li> <li><a href="/wiki/Secobarbital" title="Secobarbital">Secobarbital</a></li> <li><a href="/wiki/Talbutal" title="Talbutal">Talbutal</a></li> <li><a href="/wiki/Thiamylal" title="Thiamylal">Thiamylal</a></li> <li><a href="/wiki/Sodium_thiopental" title="Sodium thiopental">Thiopental</a></li> <li><a href="/wiki/Thiotetrabarbital" title="Thiotetrabarbital">Thiotetrabarbital</a></li> <li><a href="/wiki/Vinbarbital" title="Vinbarbital">Vinbarbital</a></li> <li><a href="/wiki/Vinylbital" title="Vinylbital">Vinylbital</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Benzodiazepine" title="Benzodiazepine">Benzodiazepines</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Brotizolam" title="Brotizolam">Brotizolam</a></li> <li><a href="/wiki/Cinolazepam" title="Cinolazepam">Cinolazepam</a></li> <li><a href="/wiki/Climazolam" title="Climazolam">Climazolam</a></li> <li><a href="/wiki/Clonazolam" title="Clonazolam">Clonazolam</a></li> <li><a href="/wiki/Doxefazepam" title="Doxefazepam">Doxefazepam</a></li> <li><a href="/wiki/Estazolam" title="Estazolam">Estazolam</a></li> <li><a href="/wiki/Flubromazolam" title="Flubromazolam">Flubromazolam</a></li> <li><a href="/wiki/Flunitrazolam" title="Flunitrazolam">Flunitrazolam</a></li> <li><a href="/wiki/Flunitrazepam" title="Flunitrazepam">Flunitrazepam</a></li> <li><a href="/wiki/Flurazepam" title="Flurazepam">Flurazepam</a></li> <li><a href="/wiki/Flutemazepam" title="Flutemazepam">Flutemazepam</a></li> <li><a href="/wiki/Flutoprazepam" title="Flutoprazepam">Flutoprazepam</a></li> <li><a href="/wiki/Loprazolam" title="Loprazolam">Loprazolam</a></li> <li><a href="/wiki/Lormetazepam" title="Lormetazepam">Lormetazepam</a></li> <li><a href="/wiki/Midazolam" title="Midazolam">Midazolam</a></li> <li><a href="/wiki/Nimetazepam" title="Nimetazepam">Nimetazepam</a></li> <li><a href="/wiki/Nitemazepam" title="Nitemazepam">Nitemazepam</a></li> <li><a href="/wiki/Nitrazepam" title="Nitrazepam">Nitrazepam</a></li> <li><a href="/wiki/Nitrazolam" title="Nitrazolam">Nitrazolam</a></li> <li><a href="/wiki/Quazepam" title="Quazepam">Quazepam</a></li> <li><a href="/wiki/Temazepam" title="Temazepam">Temazepam</a></li> <li><a href="/wiki/Triazolam" title="Triazolam">Triazolam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Carbamate" title="Carbamate">Carbamates</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/wiki/Emylcamate" title="Emylcamate">Emylcamate</a></li> <li><a href="/wiki/Ethinamate" title="Ethinamate">Ethinamate</a></li> <li><a href="/wiki/Hexapropymate" title="Hexapropymate">Hexapropymate</a></li> <li><a href="/wiki/Meprobamate" title="Meprobamate">Meprobamate</a></li> <li><a href="/wiki/Methocarbamol" title="Methocarbamol">Methocarbamol</a></li> <li><a href="/wiki/Phenprobamate" title="Phenprobamate">Phenprobamate</a></li> <li><a href="/wiki/Procymate" title="Procymate">Procymate</a></li> <li><a href="/wiki/Tybamate" title="Tybamate">Tybamate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Imidazole" title="Imidazole">Imidazoles</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Etomidate" title="Etomidate">Etomidate</a></li> <li><a href="/wiki/Metomidate" title="Metomidate">Metomidate</a></li> <li><a href="/wiki/Propoxate" title="Propoxate">Propoxate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Monoureide" class="mw-redirect" title="Monoureide">Monoureides</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acecarbromal" title="Acecarbromal">Acecarbromal</a></li> <li><a href="/wiki/Apronal" title="Apronal">Apronal (apronalide)</a></li> <li><a href="/wiki/Bromisoval" title="Bromisoval">Bromisoval</a></li> <li><a href="/w/index.php?title=Capuride&action=edit&redlink=1" class="new" title="Capuride (page does not exist)">Capuride</a></li> <li><a href="/wiki/Carbromal" title="Carbromal">Carbromal</a></li> <li><a href="/w/index.php?title=Ectylurea&action=edit&redlink=1" class="new" title="Ectylurea (page does not exist)">Ectylurea</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Neuroactive_steroid" class="mw-redirect" title="Neuroactive steroid">Neuroactive steroids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acebrochol" title="Acebrochol">Acebrochol</a></li> <li><a href="/wiki/Allopregnanolone" title="Allopregnanolone">Allopregnanolone</a></li> <li><a href="/wiki/Alfadolone" title="Alfadolone">Alphadolone</a></li> <li><a href="/wiki/Alphaxolone" class="mw-redirect" title="Alphaxolone">Alphaxolone</a></li> <li><a href="/wiki/Eltanolone" class="mw-redirect" title="Eltanolone">Eltanolone</a></li> <li><a href="/wiki/Hydroxydione" title="Hydroxydione">Hydroxydione</a></li> <li><a href="/wiki/Minaxolone" title="Minaxolone">Minaxolone</a></li> <li><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Nonbenzodiazepine" title="Nonbenzodiazepine">Nonbenzodiazepines</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Eszopiclone" title="Eszopiclone">Eszopiclone</a></li> <li><a href="/wiki/Indiplon" title="Indiplon">Indiplon</a></li> <li><a href="/wiki/Lirequinil" title="Lirequinil">Lirequinil</a></li> <li><a href="/wiki/Necopidem" title="Necopidem">Necopidem</a></li> <li><a href="/wiki/Pazinaclone" title="Pazinaclone">Pazinaclone</a></li> <li><a href="/wiki/Saripidem" title="Saripidem">Saripidem</a></li> <li><a href="/wiki/Suproclone" title="Suproclone">Suproclone</a></li> <li><a href="/wiki/Suriclone" title="Suriclone">Suriclone</a></li> <li><a href="/wiki/Zaleplon" title="Zaleplon">Zaleplon</a></li> <li><a href="/wiki/Zolpidem" title="Zolpidem">Zolpidem</a></li> <li><a href="/wiki/Zopiclone" title="Zopiclone">Zopiclone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Phenol" title="Phenol">Phenols</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Propofol" title="Propofol">Propofol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Piperidinedione" class="mw-redirect" title="Piperidinedione">Piperidinediones</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glutethimide" title="Glutethimide">Glutethimide</a></li> <li><a href="/wiki/Methyprylon" title="Methyprylon">Methyprylon</a></li> <li><a href="/wiki/Pyrithyldione" title="Pyrithyldione">Pyrithyldione</a></li> <li><a href="/wiki/Piperidione" title="Piperidione">Piperidione</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Quinazolinone" title="Quinazolinone">Quinazolinones</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Afloqualone" title="Afloqualone">Afloqualone</a></li> <li><a href="/wiki/Cloroqualone" title="Cloroqualone">Cloroqualone</a></li> <li><a href="/wiki/Diproqualone" title="Diproqualone">Diproqualone</a></li> <li><a href="/wiki/Etaqualone" title="Etaqualone">Etaqualone</a></li> <li><a href="/wiki/Mebroqualone" title="Mebroqualone">Mebroqualone</a></li> <li><a href="/wiki/Mecloqualone" title="Mecloqualone">Mecloqualone</a></li> <li><a href="/wiki/Methaqualone" title="Methaqualone">Methaqualone</a></li> <li><a href="/wiki/Methylmethaqualone" title="Methylmethaqualone">Methylmethaqualone</a></li> <li><a href="/wiki/Nitromethaqualone" title="Nitromethaqualone">Nitromethaqualone</a></li> <li><a href="/wiki/SL-164" title="SL-164">SL-164</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetophenone" title="Acetophenone">Acetophenone</a></li> <li><a href="/wiki/Acetylglycinamide_chloral_hydrate" title="Acetylglycinamide chloral hydrate">Acetylglycinamide chloral hydrate</a></li> <li><a href="/wiki/Bromide" title="Bromide">Bromide</a> compounds <ul><li><a href="/wiki/Lithium_bromide" title="Lithium bromide">Lithium bromide</a></li> <li><a href="/wiki/Potassium_bromide" title="Potassium bromide">Potassium bromide</a></li> <li><a href="/wiki/Sodium_bromide" title="Sodium bromide">Sodium bromide</a></li></ul></li> <li><a href="/wiki/Centalun" title="Centalun">Centalun</a></li> <li><a href="/wiki/Chloral_betaine" title="Chloral betaine">Chloral betaine</a></li> <li><a href="/wiki/Chloral_hydrate" title="Chloral hydrate">Chloral hydrate</a></li> <li><a href="/wiki/Chloralose" title="Chloralose">Chloralose</a></li> <li><a href="/wiki/Clomethiazole" title="Clomethiazole">Clomethiazole</a></li> <li><a href="/wiki/Dichloralphenazone" title="Dichloralphenazone">Dichloralphenazone</a></li> <li><a href="/wiki/Gaboxadol" title="Gaboxadol">Gaboxadol</a></li> <li><a href="/wiki/Kavalactone" title="Kavalactone">Kavalactones</a></li> <li><a href="/wiki/Loreclezole" title="Loreclezole">Loreclezole</a></li> <li><a href="/wiki/Paraldehyde" title="Paraldehyde">Paraldehyde</a></li> <li><a href="/wiki/Petrichloral" title="Petrichloral">Petrichloral</a></li> <li><a href="/w/index.php?title=Sulfonylalkane&action=edit&redlink=1" class="new" title="Sulfonylalkane (page does not exist)">Sulfonylalkanes</a> <ul><li><a href="/wiki/Sulfonmethane" title="Sulfonmethane">Sulfonmethane (sulfonal)</a></li> <li><a href="/wiki/Tetronal" title="Tetronal">Tetronal</a></li> <li><a href="/wiki/Trional" title="Trional">Trional</a></li></ul></li> <li><a href="/wiki/Triclofos" title="Triclofos">Triclofos</a></li> <li><a href="/wiki/Sesquiterpene" title="Sesquiterpene">Sesquiterpene</a> <ul><li><a href="/wiki/Isovaleramide" title="Isovaleramide">Isovaleramide</a></li> <li><a href="/wiki/Isovaleric_acid" title="Isovaleric acid">Isovaleric acid</a></li> <li><a href="/wiki/Valerenic_acid" title="Valerenic acid">Valerenic acid</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GABAB_receptor" title="GABAB receptor">GABA<sub>B</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/1,4-Butanediol" title="1,4-Butanediol">1,4-Butanediol</a></li> <li><a href="/wiki/4-Fluorophenibut" title="4-Fluorophenibut">4-Fluorophenibut</a></li> <li><a href="/wiki/Aceburic_acid" title="Aceburic acid">Aceburic acid</a></li> <li><a href="/wiki/Baclofen" title="Baclofen">Baclofen</a></li> <li><a href="/wiki/GABOB" class="mw-redirect" title="GABOB">GABOB</a></li> <li><a href="/wiki/Gamma-Hydroxybutyric_acid" class="mw-redirect" title="Gamma-Hydroxybutyric acid">GHB</a> (<a href="/wiki/Sodium_oxybate" title="Sodium oxybate">sodium oxybate</a>)</li> <li><a href="/wiki/Gamma-Butyrolactone" class="mw-redirect" title="Gamma-Butyrolactone">GBL</a></li> <li><a href="/wiki/Gamma-Valerolactone" class="mw-redirect" title="Gamma-Valerolactone">GVL</a></li> <li><a href="/wiki/Phenibut" title="Phenibut">Phenibut</a></li> <li><a href="/wiki/Tolibut" title="Tolibut">Tolibut</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/H1_receptor" class="mw-redirect" title="H1 receptor">H<sub>1</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Histamine_antagonist" class="mw-redirect" title="Histamine antagonist">Antihistamines</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Captodiame" title="Captodiame">Captodiame</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a></li> <li><a href="/wiki/Doxylamine" title="Doxylamine">Doxylamine</a></li> <li><a href="/wiki/Hydroxyzine" title="Hydroxyzine">Hydroxyzine</a></li> <li><a href="/wiki/Methapyrilene" title="Methapyrilene">Methapyrilene</a></li> <li><a href="/wiki/Perlapine" title="Perlapine">Perlapine</a></li> <li><a href="/wiki/Pheniramine" title="Pheniramine">Pheniramine</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Propiomazine" title="Propiomazine">Propiomazine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Antidepressant" title="Antidepressant">Antidepressants</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Serotonin_antagonists_and_reuptake_inhibitors" class="mw-redirect" title="Serotonin antagonists and reuptake inhibitors">Serotonin antagonists and reuptake inhibitors</a> <ul><li><a href="/wiki/Etoperidone" title="Etoperidone">Etoperidone</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li></ul></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> <ul><li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Doxepin" title="Doxepin">Doxepin</a></li> <li><a href="/wiki/Trimipramine" title="Trimipramine">Trimipramine</a>, etc.</li></ul></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> <ul><li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a>, etc.</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Antipsychotic" title="Antipsychotic">Antipsychotics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> <ul><li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a>, etc.</li></ul></li> <li><a href="/wiki/Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> <ul><li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a>, etc.</li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α<sub>2</sub>-Adrenergic</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Clonidine" title="Clonidine">Clonidine</a></li> <li><a href="/wiki/Detomidine" title="Detomidine">Detomidine</a></li> <li><a href="/wiki/Dexmedetomidine" title="Dexmedetomidine">Dexmedetomidine</a></li> <li><a href="/wiki/Lofexidine" title="Lofexidine">Lofexidine</a></li> <li><a href="/wiki/Medetomidine" title="Medetomidine">Medetomidine</a></li> <li><a href="/wiki/Romifidine" title="Romifidine">Romifidine</a></li> <li><a href="/wiki/Tizanidine" title="Tizanidine">Tizanidine</a></li> <li><a href="/wiki/Xylazine" title="Xylazine">Xylazine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">5-HT<sub>2A</sub></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Antidepressant" title="Antidepressant">Antidepressants</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> <ul><li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Doxepin" title="Doxepin">Doxepin</a></li> <li><a href="/wiki/Trimipramine" title="Trimipramine">Trimipramine</a>, etc.</li></ul></li> <li><a href="/wiki/Tetracyclic_antidepressant" title="Tetracyclic antidepressant">Tetracyclic antidepressants</a> <ul><li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a>, etc.</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Antipsychotic" title="Antipsychotic">Antipsychotics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Typical_antipsychotic" title="Typical antipsychotic">Typical antipsychotics</a> <ul><li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a>, etc.</li></ul></li> <li><a href="/wiki/Atypical_antipsychotic" title="Atypical antipsychotic">Atypical antipsychotics</a> <ul><li><a href="/wiki/Olanzapine" title="Olanzapine">Olanzapine</a></li> <li><a href="/wiki/Quetiapine" title="Quetiapine">Quetiapine</a></li> <li><a href="/wiki/Risperidone" title="Risperidone">Risperidone</a>, etc.</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Niaprazine" title="Niaprazine">Niaprazine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Melatonin_receptor" title="Melatonin receptor">Melatonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Agomelatine" title="Agomelatine">Agomelatine</a></li> <li><a href="/wiki/Melatonin_(medication)" class="mw-redirect" title="Melatonin (medication)">Melatonin</a></li> <li><a href="/wiki/Ramelteon" title="Ramelteon">Ramelteon</a></li> <li><a href="/wiki/Tasimelteon" title="Tasimelteon">Tasimelteon</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Orexin_receptor" title="Orexin receptor">Orexin</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Daridorexant" title="Daridorexant">Daridorexant</a></li> <li><a href="/wiki/Lemborexant" title="Lemborexant">Lemborexant</a></li> <li><a href="/wiki/Suvorexant" title="Suvorexant">Suvorexant</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Gabapentinoid" title="Gabapentinoid"><abbr title="alpha2delta subunit">α<sub>2</sub>δ</abbr> <abbr title="voltage-gated calcium channel">VDCC</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/wiki/Phenibut" title="Phenibut">Phenibut</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a> <ul><li><a href="/wiki/Cannabis_(drug)" title="Cannabis (drug)">Cannabis</a></li></ul></li> <li><a href="/w/index.php?title=Chlorophenylalkyldiol&action=edit&redlink=1" class="new" title="Chlorophenylalkyldiol (page does not exist)">Chlorophenylalkyldiols</a> <ul><li><a href="/wiki/Fenpentadiol" title="Fenpentadiol">Fenpentadiol</a></li> <li><a href="/wiki/Metaglycodol" title="Metaglycodol">Metaglycodol</a></li> <li><a href="/wiki/Phenaglycodol" title="Phenaglycodol">Phenaglycodol</a></li></ul></li> <li><a href="/wiki/2,2-Diethyl-1,3-propanediol" class="mw-redirect" title="2,2-Diethyl-1,3-propanediol">Diethylpropanediol</a></li> <li><a href="/wiki/Evoxine" title="Evoxine">Evoxine</a></li> <li><a href="/wiki/Fenadiazole" title="Fenadiazole">Fenadiazole</a></li> <li><a href="/wiki/Guaifenesin" title="Guaifenesin">Guaifenesin</a>-related <a href="/wiki/Muscle_relaxant" title="Muscle relaxant">muscle relaxants</a> <ul><li><a href="/wiki/Chlorphenesin" class="mw-redirect" title="Chlorphenesin">Chlorphenesin</a></li> <li><a href="/wiki/Mephenesin" title="Mephenesin">Mephenesin</a></li> <li><a href="/wiki/Mephenoxalone" title="Mephenoxalone">Mephenoxalone</a></li> <li><a href="/wiki/Metaxalone" title="Metaxalone">Metaxalone</a></li> <li><a href="/wiki/Methocarbamol" title="Methocarbamol">Methocarbamol</a></li></ul></li> <li><a href="/wiki/Midaflur" title="Midaflur">Midaflur</a></li> <li><a href="/wiki/Opioid" title="Opioid">Opioids</a> (e.g., <a href="/wiki/Morphine" title="Morphine">morphine</a>)</li> <li><a href="/wiki/Passiflora" title="Passiflora">Passion flower</a></li> <li><a href="/wiki/Scopolamine" title="Scopolamine">Scopolamine</a></li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li> <li><a href="/wiki/UMB68" class="mw-redirect" title="UMB68">UMB68</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"></div><div role="navigation" class="navbox" aria-labelledby="Culture_of_indigenous_Oceania" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Culture_of_Oceania" title="Template:Culture of Oceania"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Culture_of_Oceania" title="Template talk:Culture of Oceania"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Culture_of_Oceania" title="Special:EditPage/Template:Culture of Oceania"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Culture_of_indigenous_Oceania" style="font-size:114%;margin:0 4em"><a href="/wiki/List_of_Indigenous_peoples#Oceania" title="List of Indigenous peoples">Culture of indigenous Oceania</a></div></th></tr><tr><td class="navbox-abovebelow" colspan="2"><div>List of resources about traditional arts and culture of Oceania</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oceanian_art" title="Oceanian art">Art</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Easter_Island#Ahu" title="Easter Island">Ahu</a></li> <li><a href="/wiki/Indigenous_Australian_art" title="Indigenous Australian art">Australia</a></li> <li><a href="/wiki/Austronesian_peoples#Arts" title="Austronesian peoples">Austronesia</a></li> <li><a href="/wiki/Cook_Islands" title="Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Kapa" title="Kapa">kapa (Hawaiʻi)</a></li> <li><a href="/wiki/Lei_(garland)" title="Lei (garland)">Lei</a></li> <li><a href="/wiki/Magimagi" title="Magimagi">magimagi</a></li> <li><a href="/wiki/Moai" title="Moai">moai</a></li> <li><a href="/wiki/New_Zealand_art" title="New Zealand art">New Zealand</a> <ul><li><a href="/wiki/Category:M%C4%81ori_art" title="Category:Māori art">Māori</a></li></ul></li> <li><a href="/wiki/Nguzu_nguzu" title="Nguzu nguzu">nguzu nguzu</a></li> <li><a href="/wiki/Oceanian_art" title="Oceanian art">Oceania</a></li> <li><a href="/wiki/Papua_New_Guinean_art" title="Papua New Guinean art">Papua New Guinea</a></li> <li><a href="/wiki/Reimiro" title="Reimiro">reimiro</a></li> <li><a href="/wiki/T%C4%81_moko" title="Tā moko">tā moko</a></li> <li><a href="/wiki/Tabua" title="Tabua">tabua</a></li> <li><a href="/wiki/Ta%CA%BBovala" title="Taʻovala">taʻovala</a></li> <li><a href="/wiki/Tapa_cloth" title="Tapa cloth">tapa ["masi" (Fiji), "ngatu" (Tonga), "siapo" (Sāmoa), " ʻuha" (Rotuma)]</a></li> <li><a href="/wiki/Tattoo" title="Tattoo">tattoo</a></li> <li><a href="/wiki/T%C4%93fui" title="Tēfui">tēfui</a></li> <li><a href="/wiki/Tivaevae" title="Tivaevae">tivaevae</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Broad culture</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Areca_nut" title="Areca nut">areca nut</a></li> <li><a class="mw-selflink selflink">"yaqona" (Fiji), or "sakau" (Pohnpei)</a></li> <li><a href="/wiki/Kava_culture" title="Kava culture">Kava culture</a></li> <li><a href="/wiki/Lapita_culture" title="Lapita culture">Lapita</a></li> <li><a href="/wiki/M%C4%81ori_culture" title="Māori culture">Māori</a></li> <li><a href="/wiki/Polynesian_culture" title="Polynesian culture">Polynesia</a></li> <li><a href="/wiki/Samoa_%27ava_ceremony" class="mw-redirect" title="Samoa 'ava ceremony">Sāmoa 'ava ceremony</a></li> <li><a href="/wiki/History_of_wood_carving#Aboriginal" title="History of wood carving">Wood carving</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Geo-specific,<br />general</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Indigenous_Australians#Culture" title="Indigenous Australians">Australia</a> <ul><li><a href="/wiki/Australian_Aboriginal_astronomy" title="Australian Aboriginal astronomy">Australian Aboriginal astronomy</a>)</li></ul></li> <li><a href="/wiki/Austronesian_peoples#Culture" title="Austronesian peoples">Austronesia</a></li> <li><a href="/wiki/Caroline_Islands#People_and_culture" title="Caroline Islands">Caroline Islands</a>, <i>-<a href="/wiki/Pwo" title="Pwo">Pwo</a></i></li> <li><a href="/wiki/Moriori#Revival_of_culture" title="Moriori">Chatham Islands</a></li> <li><a href="/wiki/Cook_Islands#Culture" title="Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Easter_Island#Culture" title="Easter Island">Easter Island</a></li> <li><a href="/wiki/Culture_of_Fiji" title="Culture of Fiji">Fiji</a> <ul><li><i><a href="/wiki/Lau_Islands#Culture_and_economy" title="Lau Islands">Lau Islands</a></i></li> <li><i><a href="/wiki/Fijian_traditions_and_ceremonies" title="Fijian traditions and ceremonies">traditions and ceremonies</a></i></li></ul></li> <li><a href="/wiki/Guam#Culture" title="Guam">Guam</a> <ul><li><i><a href="/wiki/Lomilomi_massage" title="Lomilomi massage">Lomilomi massage</a></i></li></ul></li> <li><a href="/wiki/Culture_of_Kiribati" title="Culture of Kiribati">Kiribati</a></li> <li><a href="/wiki/Culture_of_the_Marquesas_Islands" title="Culture of the Marquesas Islands">French Polynesia's Marquesas Islands</a></li> <li><a href="/wiki/Federated_States_of_Micronesia#Culture" title="Federated States of Micronesia">Federated States of Micronesia</a></li> <li><a href="/wiki/Culture_of_Nauru" title="Culture of Nauru">Nauru</a></li> <li><a href="/wiki/New_Caledonia#Culture" title="New Caledonia">New Caledonia</a></li> <li><a href="/wiki/Culture_of_New_Zealand" title="Culture of New Zealand">New Zealand</a> <ul><li><a href="/wiki/M%C4%81ori_culture" title="Māori culture">Māori</a></li></ul></li> <li><a href="/wiki/Niue#Culture" title="Niue">Niue</a></li> <li><a href="/wiki/Norfolk_Island#Culture" title="Norfolk Island">Norfolk Island</a></li> <li><a href="/wiki/Palau#Culture" title="Palau">Palau</a></li> <li><a href="/wiki/Culture_of_Papua_New_Guinea" title="Culture of Papua New Guinea">Papua New Guinea</a></li> <li><a href="/wiki/Pitcairn_Islands#Culture_and_religion" title="Pitcairn Islands">Pitcairn Islands</a></li> <li><a href="/wiki/Samoan_culture" class="mw-redirect" title="Samoan culture">Sāmoa</a></li> <li><a href="/wiki/Culture_of_the_Solomon_Islands" title="Culture of the Solomon Islands">Solomon Islands</a></li> <li><a href="/wiki/Culture_of_Tonga" title="Culture of Tonga">Tonga</a></li> <li><a href="/wiki/Torres_Strait_Islanders#Culture" title="Torres Strait Islanders">Torres Strait Islands</a></li> <li><a href="/wiki/Tuvalu#Culture" title="Tuvalu">Tuvalu</a></li> <li><a href="/wiki/Culture_of_Vanuatu" title="Culture of Vanuatu">Vanuatu</a></li> <li><a href="/wiki/Wallis_and_Futuna#Culture" title="Wallis and Futuna">Wallis and Futuna</a></li> <li><a href="/wiki/Polynesian_navigation" title="Polynesian navigation">Polynesian Navigation</a></li> <li><a href="/wiki/Micronesian_navigation" title="Micronesian navigation">Micronesian Navigation</a></li> <li><a href="/wiki/Marshallese_culture" class="mw-redirect" title="Marshallese culture">Marshall Islands</a> <ul><li><i><a href="/wiki/Marshall_Islands_stick_chart" title="Marshall Islands stick chart">Stick charts of</a></i></li></ul></li> <li><a href="/wiki/Yap#Culture" title="Yap">Yap</a> <ul><li><i><a href="/wiki/Yap#Navigation_(sailing)" title="Yap">navigation</a></i></li> <li><i><a href="/wiki/Weriyeng" title="Weriyeng">Weriyeng navigation school</a></i></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Canoes</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aboriginal_dugout_canoe" title="Aboriginal dugout canoe">Aboriginal dugout</a></li> <li><a href="/wiki/Alingano_Maisu" title="Alingano Maisu">Alingano Maisu</a></li> <li><a href="/wiki/Balangay" title="Balangay">Bangka</a></li> <li><a href="/wiki/Drua" title="Drua">Drua</a></li> <li><a href="/wiki/Dugout_(boat)#Pacific_Islands" class="mw-redirect" title="Dugout (boat)">Dugout (boat)</a></li> <li><a href="/wiki/H%C5%8Dk%C5%ABle%CA%BBa" title="Hōkūleʻa">Hōkūleʻa</a></li> <li><a href="/wiki/Kaep" title="Kaep">Kaep</a></li> <li><a href="/wiki/Karakoa" title="Karakoa">Karakoa</a></li> <li><a href="/wiki/M%C4%81ori_migration_canoes" title="Māori migration canoes">Māori migration</a></li> <li><a href="/wiki/Outrigger_canoe" class="mw-redirect" title="Outrigger canoe">Outrigger</a></li> <li><a href="/wiki/Paopao_(canoe)" title="Paopao (canoe)"> Paopao (Tuvalu)</a></li> <li><a href="/wiki/Paraw" title="Paraw">Paraw</a></li> <li><a href="/wiki/Canoe_sailing#Polynesian_sailing_canoes" title="Canoe sailing">Polynesian sailing</a></li> <li><a href="/wiki/Proa" title="Proa">Proa</a></li> <li><a href="/wiki/Vinta" title="Vinta">Vinta</a></li> <li><a href="/wiki/Waka_(canoe)" title="Waka (canoe)">Waka</a> <ul><li><a href="/wiki/List_of_M%C4%81ori_waka" title="List of Māori waka">list</a></li></ul></li> <li><a href="/wiki/Walap" title="Walap">Walap</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Dance</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/%CA%BBAparima" title="ʻAparima">ʻAparima</a></li> <li><a href="/wiki/Cibi" title="Cibi">cibi</a></li> <li><a href="/wiki/Fara_(Rotuman_festivity)" title="Fara (Rotuman festivity)">fara</a></li> <li><a href="/wiki/Fire_performance" title="Fire performance">fire dancing</a></li> <li><a href="/wiki/Firewalking" title="Firewalking">firewalking</a></li> <li><a href="/wiki/Haka" title="Haka">haka</a></li> <li><a href="/wiki/Hivinau" title="Hivinau">hivinau</a></li> <li><a href="/wiki/Hula" title="Hula">hula</a></li> <li><a href="/wiki/Kailao" title="Kailao">kailao</a></li> <li><a href="/wiki/Kapa_haka" title="Kapa haka">kapa haka</a></li> <li><a href="/wiki/Dance_in_Kiribati" title="Dance in Kiribati">Kiribati</a></li> <li><a href="/wiki/Meke" title="Meke">meke</a></li> <li><a href="/wiki/%27ote%27a" title="'ote'a">'ote'a</a></li> <li><a href="/wiki/Pa%27o%27a" class="mw-redirect" title="Pa'o'a">pa'o'a</a></li> <li><a href="/wiki/Poi_(performance_art)" title="Poi (performance art)">poi</a></li> <li><a href="/wiki/Dance_in_Rotuma" title="Dance in Rotuma">Rotuma</a></li> <li><a href="/wiki/Samoan_culture#Dance" class="mw-redirect" title="Samoan culture">siva</a></li> <li><a href="/wiki/Category:Dances_of_Tahiti" title="Category:Dances of Tahiti">Tahiti</a></li> <li><a href="/wiki/Tamure" title="Tamure">tāmūrē</a></li> <li><a href="/wiki/Tautoga" title="Tautoga">tautoga</a></li> <li><a href="/wiki/Category:Dances_of_Tonga" title="Category:Dances of Tonga">Tonga</a></li> <li><a href="/wiki/Music_of_Tuvalu" title="Music of Tuvalu">Tuvalu</a></li> <li><a href="/wiki/%27upa%27upa" title="'upa'upa">'upa'upa</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Festivals</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Australia <ul><li><a href="/wiki/Garma_Festival_of_Traditional_Cultures" title="Garma Festival of Traditional Cultures">Garma Festival</a></li></ul></li> <li>Hawaiʻi <ul><li><a href="/wiki/Aloha_Festivals" title="Aloha Festivals">Aloha Festivals</a></li> <li><a href="/wiki/Merrie_Monarch_Festival" title="Merrie Monarch Festival">Merrie Monarch Festival</a></li> <li><a href="/wiki/World_Invitational_Hula_Festival" title="World Invitational Hula Festival">World Invitational Hula Festival</a></li></ul></li> <li><a href="/wiki/List_of_festivals_in_Fiji" title="List of festivals in Fiji">Fiji</a></li> <li>New Zealand <ul><li><a href="/wiki/Pasifika_Festival" title="Pasifika Festival">Pasifika Festival</a></li> <li><a href="/wiki/Te_Matatini" title="Te Matatini">Te Matatini</a></li></ul></li> <li><a href="/wiki/Pacific_Community" title="Pacific Community">Pacific Community</a> <ul><li><a href="/wiki/Festival_of_Pacific_Arts" title="Festival of Pacific Arts">Festival of Pacific Arts</a></li></ul></li> <li><a href="/wiki/Category:Festivals_in_Papua_New_Guinea" title="Category:Festivals in Papua New Guinea">Papua New Guinea</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oceanic_languages" title="Oceanic languages">Languages</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">by area</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible autocollapse navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Oceania_topic" title="Template:Oceania topic"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Oceania_topic" title="Template talk:Oceania topic"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Oceania_topic" title="Special:EditPage/Template:Oceania topic"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Languages_of_Oceania" style="font-size:114%;margin:0 4em"><a href="/wiki/Languages_of_Oceania" title="Languages of Oceania">Languages of Oceania </a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Sovereign states</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Languages_of_Australia" title="Languages of Australia">Australia</a></li> <li><a href="/wiki/Languages_of_the_Federated_States_of_Micronesia" class="mw-redirect" title="Languages of the Federated States of Micronesia">Federated States of Micronesia</a></li> <li><a href="/wiki/Languages_of_Fiji" title="Languages of Fiji">Fiji</a></li> <li><a href="/wiki/Languages_of_Kiribati" class="mw-redirect" title="Languages of Kiribati">Kiribati</a></li> <li><a href="/wiki/Languages_of_the_Marshall_Islands" class="mw-redirect" title="Languages of the Marshall Islands">Marshall Islands</a></li> <li><a href="/wiki/Languages_of_Nauru" class="mw-redirect" title="Languages of Nauru">Nauru</a></li> <li><a href="/wiki/Languages_of_New_Zealand" title="Languages of New Zealand">New Zealand</a></li> <li><a href="/wiki/Languages_of_Palau" class="mw-redirect" title="Languages of Palau">Palau</a></li> <li><a href="/wiki/Languages_of_Papua_New_Guinea" title="Languages of Papua New Guinea">Papua New Guinea</a></li> <li><a href="/wiki/Languages_of_Samoa" class="mw-redirect" title="Languages of Samoa">Samoa</a></li> <li><a href="/wiki/Languages_of_Solomon_Islands" class="mw-redirect" title="Languages of Solomon Islands">Solomon Islands</a></li> <li><a href="/wiki/Languages_of_Tonga" class="mw-redirect" title="Languages of Tonga">Tonga</a></li> <li><a href="/wiki/Languages_of_Tuvalu" class="mw-redirect" title="Languages of Tuvalu">Tuvalu</a></li> <li><a href="/wiki/Languages_of_Vanuatu" title="Languages of Vanuatu">Vanuatu</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Associated states<br />of New Zealand</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Languages_of_the_Cook_Islands" class="mw-redirect" title="Languages of the Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Languages_of_Niue" class="mw-redirect" title="Languages of Niue">Niue</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Dependencies<br />and other territories</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Languages_of_American_Samoa" class="mw-redirect" title="Languages of American Samoa">American Samoa</a></li> <li><a href="/wiki/Languages_of_Christmas_Island" class="mw-redirect" title="Languages of Christmas Island">Christmas Island</a></li> <li><a href="/wiki/Languages_of_the_Cocos_(Keeling)_Islands" class="mw-redirect" title="Languages of the Cocos (Keeling) Islands">Cocos (Keeling) Islands</a></li> <li><a href="/wiki/Languages_of_Easter_Island" class="mw-redirect" title="Languages of Easter Island">Easter Island</a></li> <li><a href="/wiki/Languages_of_French_Polynesia" class="mw-redirect" title="Languages of French Polynesia">French Polynesia</a></li> <li><a href="/wiki/Languages_of_Guam" class="mw-redirect" title="Languages of Guam">Guam</a></li> <li><a href="/wiki/Languages_of_Hawaii" class="mw-redirect" title="Languages of Hawaii">Hawaii</a></li> <li><a href="/wiki/Languages_of_New_Caledonia" title="Languages of New Caledonia">New Caledonia</a></li> <li><a href="/wiki/Languages_of_Norfolk_Island" title="Languages of Norfolk Island">Norfolk Island</a></li> <li><a href="/wiki/Languages_of_the_Northern_Mariana_Islands" class="mw-redirect" title="Languages of the Northern Mariana Islands">Northern Mariana Islands</a></li> <li><a href="/wiki/Languages_of_the_Pitcairn_Islands" class="mw-redirect" title="Languages of the Pitcairn Islands">Pitcairn Islands</a></li> <li><a href="/wiki/Languages_of_Tokelau" title="Languages of Tokelau">Tokelau</a></li> <li><a href="/wiki/Languages_of_Wallis_and_Futuna" class="mw-redirect" title="Languages of Wallis and Futuna">Wallis and Futuna</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">by category</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Category:Languages_of_Oceania" title="Category:Languages of Oceania">Languages of Oceania</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Oceanian_literature" title="Oceanian literature">Literature</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible autocollapse navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Oceania_topic" title="Template:Oceania topic"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Oceania_topic" title="Template talk:Oceania topic"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Oceania_topic" title="Special:EditPage/Template:Oceania topic"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Literature_of_Oceania" style="font-size:114%;margin:0 4em"><a href="/wiki/Literature_of_Oceania" class="mw-redirect" title="Literature of Oceania">Literature of Oceania </a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Sovereign states</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Literature_of_Australia" class="mw-redirect" title="Literature of Australia">Australia</a></li> <li><a href="/w/index.php?title=Literature_of_the_Federated_States_of_Micronesia&action=edit&redlink=1" class="new" title="Literature of the Federated States of Micronesia (page does not exist)">Federated States of Micronesia</a></li> <li><a href="/wiki/Literature_of_Fiji" class="mw-redirect" title="Literature of Fiji">Fiji</a></li> <li><a href="/w/index.php?title=Literature_of_Kiribati&action=edit&redlink=1" class="new" title="Literature of Kiribati (page does not exist)">Kiribati</a></li> <li><a href="/w/index.php?title=Literature_of_the_Marshall_Islands&action=edit&redlink=1" class="new" title="Literature of the Marshall Islands (page does not exist)">Marshall Islands</a></li> <li><a href="/w/index.php?title=Literature_of_Nauru&action=edit&redlink=1" class="new" title="Literature of Nauru (page does not exist)">Nauru</a></li> <li><a href="/wiki/Literature_of_New_Zealand" class="mw-redirect" title="Literature of New Zealand">New Zealand</a></li> <li><a href="/w/index.php?title=Literature_of_Palau&action=edit&redlink=1" class="new" title="Literature of Palau (page does not exist)">Palau</a></li> <li><a href="/wiki/Literature_of_Papua_New_Guinea" class="mw-redirect" title="Literature of Papua New Guinea">Papua New Guinea</a></li> <li><a href="/wiki/Literature_of_Samoa" class="mw-redirect" title="Literature of Samoa">Samoa</a></li> <li><a href="/w/index.php?title=Literature_of_Solomon_Islands&action=edit&redlink=1" class="new" title="Literature of Solomon Islands (page does not exist)">Solomon Islands</a></li> <li><a href="/wiki/Literature_of_Tonga" class="mw-redirect" title="Literature of Tonga">Tonga</a></li> <li><a href="/w/index.php?title=Literature_of_Tuvalu&action=edit&redlink=1" class="new" title="Literature of Tuvalu (page does not exist)">Tuvalu</a></li> <li><a href="/wiki/Literature_of_Vanuatu" title="Literature of Vanuatu">Vanuatu</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Associated states<br />of New Zealand</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Literature_of_the_Cook_Islands" class="mw-redirect" title="Literature of the Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Literature_of_Niue" class="mw-redirect" title="Literature of Niue">Niue</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Dependencies<br />and other territories</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Literature_of_American_Samoa&action=edit&redlink=1" class="new" title="Literature of American Samoa (page does not exist)">American Samoa</a></li> <li><a href="/w/index.php?title=Literature_of_Christmas_Island&action=edit&redlink=1" class="new" title="Literature of Christmas Island (page does not exist)">Christmas Island</a></li> <li><a href="/w/index.php?title=Literature_of_the_Cocos_(Keeling)_Islands&action=edit&redlink=1" class="new" title="Literature of the Cocos (Keeling) Islands (page does not exist)">Cocos (Keeling) Islands</a></li> <li><a href="/w/index.php?title=Literature_of_Easter_Island&action=edit&redlink=1" class="new" title="Literature of Easter Island (page does not exist)">Easter Island</a></li> <li><a href="/w/index.php?title=Literature_of_French_Polynesia&action=edit&redlink=1" class="new" title="Literature of French Polynesia (page does not exist)">French Polynesia</a></li> <li><a href="/w/index.php?title=Literature_of_Guam&action=edit&redlink=1" class="new" title="Literature of Guam (page does not exist)">Guam</a></li> <li><a href="/wiki/Literature_of_Hawaii" class="mw-redirect" title="Literature of Hawaii">Hawaii</a></li> <li><a href="/wiki/Literature_of_New_Caledonia" class="mw-redirect" title="Literature of New Caledonia">New Caledonia</a></li> <li><a href="/w/index.php?title=Literature_of_Norfolk_Island&action=edit&redlink=1" class="new" title="Literature of Norfolk Island (page does not exist)">Norfolk Island</a></li> <li><a href="/w/index.php?title=Literature_of_the_Northern_Mariana_Islands&action=edit&redlink=1" class="new" title="Literature of the Northern Mariana Islands (page does not exist)">Northern Mariana Islands</a></li> <li><a href="/w/index.php?title=Literature_of_the_Pitcairn_Islands&action=edit&redlink=1" class="new" title="Literature of the Pitcairn Islands (page does not exist)">Pitcairn Islands</a></li> <li><a href="/w/index.php?title=Literature_of_Tokelau&action=edit&redlink=1" class="new" title="Literature of Tokelau (page does not exist)">Tokelau</a></li> <li><a href="/w/index.php?title=Literature_of_Wallis_and_Futuna&action=edit&redlink=1" class="new" title="Literature of Wallis and Futuna (page does not exist)">Wallis and Futuna</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Music</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Music_of_the_Austral_Islands" title="Music of the Austral Islands">Austral Islands (French Polynesia)</a></li> <li><a href="/wiki/Indigenous_music_of_Australia" title="Indigenous music of Australia">Australia</a></li> <li><a href="/wiki/Austronesian_peoples#Music" title="Austronesian peoples">Austronesia</a></li> <li><a href="/wiki/Music_of_the_Cook_Islands" title="Music of the Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Music_of_Easter_Island" title="Music of Easter Island">Easter Island</a></li> <li><a href="/wiki/Music_of_Fiji" title="Music of Fiji">Fiji</a></li> <li><a href="/wiki/Music_of_Guam" title="Music of Guam">Guam</a></li> <li><a href="/wiki/Music_of_Kiribati" title="Music of Kiribati">Kiribati</a></li> <li><a href="/wiki/Lali_(drum)" title="Lali (drum)">Lali</a></li> <li><a href="/wiki/Music_of_Melanesia" title="Music of Melanesia">Melanesia</a></li> <li><a href="/wiki/Music_of_Micronesia" class="mw-redirect" title="Music of Micronesia">Micronesia</a></li> <li><a href="/wiki/Music_of_the_Federated_States_of_Micronesia" class="mw-redirect" title="Music of the Federated States of Micronesia">Federated States of Micronesia</a></li> <li><a href="/wiki/Music_of_Nauru" title="Music of Nauru">Nauru</a></li> <li><a href="/wiki/Music_of_New_Caledonia" title="Music of New Caledonia">New Caledonia</a></li> <li><a href="/wiki/Music_of_New_Zealand" title="Music of New Zealand">New Zealand</a> <ul><li><a href="/wiki/M%C4%81ori_music" title="Māori music">Māori</a></li></ul></li> <li><a href="/wiki/Music_of_Niue" title="Music of Niue">Niue</a></li> <li><a href="/wiki/Music_of_the_Northern_Mariana_Islands" title="Music of the Northern Mariana Islands">Northern Mariana Islands</a></li> <li><a href="/wiki/Music_of_Palau" title="Music of Palau">Palau</a></li> <li><a href="/wiki/Music_of_Papua_New_Guinea" title="Music of Papua New Guinea">Papua New Guinea</a></li> <li><a href="/wiki/Music_of_Polynesia" title="Music of Polynesia">Polynesia</a></li> <li><a href="/wiki/Music_of_Samoa" title="Music of Samoa">Sāmoa</a></li> <li><a href="/wiki/Slit_drum" title="Slit drum">Slit drum</a></li> <li><a href="/wiki/Music_of_Solomon_Islands" title="Music of Solomon Islands">Solomon Islands</a></li> <li><a href="/wiki/Music_of_Tahiti" title="Music of Tahiti">Tahiti</a></li> <li><a href="/wiki/Music_of_Tokelau" title="Music of Tokelau">Tokelau</a></li> <li><a href="/wiki/Music_of_Tonga" title="Music of Tonga">Tonga</a></li> <li><a href="/wiki/Music_of_Tuvalu" title="Music of Tuvalu">Tuvalu</a></li> <li><a href="/wiki/Music_of_Vanuatu" title="Music of Vanuatu">Vanuatu</a></li> <li><a href="/wiki/Music_of_Polynesia" title="Music of Polynesia">Wallis and Futuna</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Mythology</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Australian_Aboriginal_mythology" class="mw-redirect" title="Australian Aboriginal mythology">Australian Aboriginal</a></li> <li><a href="/wiki/Category:Fijian_mythology" title="Category:Fijian mythology">Fijian</a></li> <li><a href="/wiki/Mangarevan_mythology" class="mw-redirect" title="Mangarevan mythology">Mangarevan</a></li> <li><a href="/wiki/Tahiti_and_Society_Islands_mythology" title="Tahiti and Society Islands mythology">Maohi</a></li> <li><a href="/wiki/M%C4%81ori_mythology" title="Māori mythology">Māori</a></li> <li><a href="/wiki/Melanesian_mythology" title="Melanesian mythology">Melanesian</a></li> <li><a href="/wiki/Menehune" title="Menehune">Menehune</a></li> <li><a href="/wiki/Micronesian_mythology" title="Micronesian mythology">Micronesian</a></li> <li><a href="/wiki/Category:Oceanian_legendary_creatures" title="Category:Oceanian legendary creatures">Oceanian legendary creatures</a></li> <li><a href="/wiki/Polynesian_mythology" title="Polynesian mythology">Polynesian</a></li> <li><a href="/wiki/Rapa_Nui_mythology" title="Rapa Nui mythology">Rapa Nui</a></li> <li><a href="/wiki/Samoan_mythology" title="Samoan mythology">Samoan</a></li> <li><a href="/wiki/Tuvaluan_mythology" title="Tuvaluan mythology">Tuvaluan</a></li> <li><a href="/wiki/Category:Vanuatu_mythology" title="Category:Vanuatu mythology">Vanuatuan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Research</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asian_American_and_Pacific_Islander_Policy_Research_Consortium" title="Asian American and Pacific Islander Policy Research Consortium">Asian American and Pacific Islander Policy Research Consortium</a></li> <li><a href="/wiki/Australian_Institute_of_Aboriginal_and_Torres_Strait_Islander_Studies" title="Australian Institute of Aboriginal and Torres Strait Islander Studies">Australian Institute of Aboriginal and Torres Strait Islander Studies</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Indigenous_Australians" title="Indigenous Australians">Indigenous Australian</a></li> <li><a href="/wiki/Austronesian_peoples" title="Austronesian peoples">Austronesian</a></li> <li><a href="/wiki/Sama-Bajau" title="Sama-Bajau">Sama-Bajau</a></li> <li><a href="/wiki/Chamorro_people" title="Chamorro people">Chamorro</a></li> <li><a href="/wiki/Moriori" title="Moriori">Chatham Islander (Moriori <em>or</em> Rekohu)</a></li> <li><a href="/wiki/Fijians" title="Fijians">Fijian (iTaukei)</a></li> <li><a href="/wiki/Native_Hawaiians" title="Native Hawaiians">Hawaiian</a></li> <li><a href="/wiki/Ilocano_people" title="Ilocano people">Ilocano</a></li> <li><a href="/wiki/Igorot" class="mw-redirect" title="Igorot">Igorot</a></li> <li><a href="/wiki/Ivatan_people" title="Ivatan people">Ivatans</a></li> <li><a href="/wiki/Lumad" title="Lumad">Lumad</a></li> <li><a href="/wiki/M%C4%81ori_people" title="Māori people">Māori</a></li> <li><a href="/wiki/Demographics_of_the_Marshall_Islands" title="Demographics of the Marshall Islands">Marshallese</a></li> <li><a href="/wiki/Melanesians" title="Melanesians">Melanesian</a></li> <li><a href="/wiki/Micronesians" title="Micronesians">Micronesian</a></li> <li><a href="/wiki/Negrito" title="Negrito">Negrito</a></li> <li><a href="/wiki/Norfolk_Islanders" title="Norfolk Islanders">Norfolk Islander</a></li> <li><a href="/wiki/Indigenous_people_of_New_Guinea" title="Indigenous people of New Guinea">Papuan</a></li> <li><a href="/wiki/Polynesians" title="Polynesians">Polynesian</a></li> <li><a href="/wiki/Maohi" title="Maohi">Indigenous Polynesian (Mā’ohi)</a></li> <li><a href="/wiki/Rapa_Nui_people" title="Rapa Nui people">Rapa Nui</a></li> <li><a href="/wiki/Rotumans" title="Rotumans">Rotuman</a></li> <li><a href="/wiki/Samoans" title="Samoans">Samoan (Tagata Māo‘i)</a></li> <li><a href="/wiki/Tagalog_people" title="Tagalog people">Tagalog</a></li> <li><a href="/wiki/Tahitians" title="Tahitians">Tahitian</a></li> <li><a href="/wiki/Taiwanese_aborigines" class="mw-redirect" title="Taiwanese aborigines">Taiwanese aborigines</a></li> <li><a href="/wiki/Tokelauan_people" title="Tokelauan people">Tokelauan</a></li> <li><a href="/wiki/Demographics_of_Tonga" title="Demographics of Tonga">Tongan</a></li> <li><a href="/wiki/Torres_Strait_Islanders" title="Torres Strait Islanders">Torres Strait Islander</a></li> <li><a href="/wiki/Visayans" title="Visayans">Visayans</a></li> <li><a href="/wiki/Yami_people" class="mw-redirect" title="Yami people">Yami</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Religion</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible autocollapse navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Oceania_topic" title="Template:Oceania topic"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Oceania_topic" title="Template talk:Oceania topic"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Oceania_topic" title="Special:EditPage/Template:Oceania topic"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Religion_in_Oceania" style="font-size:114%;margin:0 4em"><a href="/wiki/Religion_in_Oceania" title="Religion in Oceania">Religion in Oceania </a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Sovereign states</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Religion_in_Australia" title="Religion in Australia">Australia</a></li> <li><a href="/wiki/Religion_in_the_Federated_States_of_Micronesia" title="Religion in the Federated States of Micronesia">Federated States of Micronesia</a></li> <li><a href="/wiki/Religion_in_Fiji" title="Religion in Fiji">Fiji</a></li> <li><a href="/wiki/Religion_in_Kiribati" title="Religion in Kiribati">Kiribati</a></li> <li><a href="/wiki/Religion_in_the_Marshall_Islands" title="Religion in the Marshall Islands">Marshall Islands</a></li> <li><a href="/wiki/Religion_in_Nauru" title="Religion in Nauru">Nauru</a></li> <li><a href="/wiki/Religion_in_New_Zealand" title="Religion in New Zealand">New Zealand</a></li> <li><a href="/wiki/Religion_in_Palau" title="Religion in Palau">Palau</a></li> <li><a href="/wiki/Religion_in_Papua_New_Guinea" title="Religion in Papua New Guinea">Papua New Guinea</a></li> <li><a href="/wiki/Religion_in_Samoa" title="Religion in Samoa">Samoa</a></li> <li><a href="/wiki/Religion_in_Solomon_Islands" title="Religion in Solomon Islands">Solomon Islands</a></li> <li><a href="/wiki/Religion_in_Tonga" title="Religion in Tonga">Tonga</a></li> <li><a href="/wiki/Religion_in_Tuvalu" title="Religion in Tuvalu">Tuvalu</a></li> <li><a href="/wiki/Religion_in_Vanuatu" title="Religion in Vanuatu">Vanuatu</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Associated states<br />of New Zealand</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Religion_in_the_Cook_Islands" title="Religion in the Cook Islands">Cook Islands</a></li> <li><a href="/wiki/Religion_in_Niue" class="mw-redirect" title="Religion in Niue">Niue</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Dependencies<br />and other territories</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Religion_in_American_Samoa" class="mw-redirect" title="Religion in American Samoa">American Samoa</a></li> <li><a href="/wiki/Religion_in_Christmas_Island" class="mw-redirect" title="Religion in Christmas Island">Christmas Island</a></li> <li><a href="/w/index.php?title=Religion_in_the_Cocos_(Keeling)_Islands&action=edit&redlink=1" class="new" title="Religion in the Cocos (Keeling) Islands (page does not exist)">Cocos (Keeling) Islands</a></li> <li><a href="/w/index.php?title=Religion_in_Easter_Island&action=edit&redlink=1" class="new" title="Religion in Easter Island (page does not exist)">Easter Island</a></li> <li><a href="/wiki/Religion_in_French_Polynesia" class="mw-redirect" title="Religion in French Polynesia">French Polynesia</a></li> <li><a href="/wiki/Religion_in_Guam" class="mw-redirect" title="Religion in Guam">Guam</a></li> <li><a href="/wiki/Religion_in_Hawaii" class="mw-redirect" title="Religion in Hawaii">Hawaii</a></li> <li><a href="/wiki/Religion_in_New_Caledonia" class="mw-redirect" title="Religion in New Caledonia">New Caledonia</a></li> <li><a href="/wiki/Religion_in_Norfolk_Island" class="mw-redirect" title="Religion in Norfolk Island">Norfolk Island</a></li> <li><a href="/wiki/Religion_in_the_Northern_Mariana_Islands" class="mw-redirect" title="Religion in the Northern Mariana Islands">Northern Mariana Islands</a></li> <li><a href="/wiki/Religion_in_the_Pitcairn_Islands" class="mw-redirect" title="Religion in the Pitcairn Islands">Pitcairn Islands</a></li> <li><a href="/wiki/Religion_in_Tokelau" title="Religion in Tokelau">Tokelau</a></li> <li><a href="/wiki/Religion_in_Wallis_and_Futuna" class="mw-redirect" title="Religion in Wallis and Futuna">Wallis and Futuna</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>For other topics including Oceanian <a href="/wiki/Cinema_of_Oceania" class="mw-redirect" title="Cinema of Oceania">cinema</a>, <a href="/wiki/Shell_money_in_Oceania" class="mw-redirect" title="Shell money in Oceania">indigenous currency</a>, <a href="/wiki/Category:History_of_Oceanian_clothing" title="Category:History of Oceanian clothing">dress</a>, <a href="/wiki/Category:Oceanian_folklore" title="Category:Oceanian folklore">folklore</a> and <a href="/wiki/Category:Oceanian_cuisine" title="Category:Oceanian cuisine">cuisine</a>, see <a href="/wiki/Category:Culture_of_Oceania" title="Category:Culture of Oceania">Category:Culture of Oceania</a>.</div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"></div><div role="navigation" class="navbox" aria-labelledby="Cannabinoid_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Cannabinoid_receptor_modulators" title="Template:Cannabinoid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Cannabinoid_receptor_modulators" title="Template talk:Cannabinoid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Cannabinoid_receptor_modulators" title="Special:EditPage/Template:Cannabinoid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cannabinoid_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Cannabinoid_receptor" title="Cannabinoid receptor">Cannabinoid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a><br /><span class="nobold">(<a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a>)</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cannabinoid_receptor_type_1" class="mw-redirect" title="Cannabinoid receptor type 1"><abbr title="Cannabinoid receptor type 1">CB<sub>1</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cannabinoid receptor type 1</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists<br /><i>(abridged,<br /><a href="/wiki/Template:Cannabinoids" title="Template:Cannabinoids">full list</a>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Arachidonoylglycerol" title="2-Arachidonoylglycerol">2-AG</a></li> <li><a href="/wiki/2-Arachidonyl_glyceryl_ether" title="2-Arachidonyl glyceryl ether">2-AGE (noladin ether)</a></li> <li><a href="/wiki/11-Hydroxy-THC" title="11-Hydroxy-THC">11-Hydroxy-THC</a></li> <li><a href="/wiki/Amyrin" title="Amyrin">α-Amyrin · β-Amyrin</a></li> <li><a href="/wiki/AB-CHMINACA" title="AB-CHMINACA">AB-CHMINACA</a></li> <li><a href="/w/index.php?title=AM-1172&action=edit&redlink=1" class="new" title="AM-1172 (page does not exist)">AM-1172</a></li> <li><a href="/wiki/AM-1220" title="AM-1220">AM-1220</a></li> <li><a href="/wiki/AM-1221" title="AM-1221">AM-1221</a></li> <li><a href="/wiki/AM-1235" title="AM-1235">AM-1235</a></li> <li><a href="/wiki/AM-2201" title="AM-2201">AM-2201</a></li> <li><a href="/wiki/AM-2232" title="AM-2232">AM-2232</a></li> <li><a href="/wiki/Anandamide" title="Anandamide">Anandamide</a></li> <li><a href="/w/index.php?title=Arvanil&action=edit&redlink=1" class="new" title="Arvanil (page does not exist)">Arvanil</a></li> <li><a href="/wiki/AZ-11713908" title="AZ-11713908">AZ-11713908</a></li> <li><a href="/wiki/Cannabinol" title="Cannabinol">Cannabinol</a></li> <li><a href="/wiki/CB-13" title="CB-13">CB-13</a></li> <li><a href="/wiki/CP_47,497" title="CP 47,497">CP 47,497</a></li> <li><a href="/wiki/CP_55,940" title="CP 55,940">CP 55,940</a></li> <li><a href="/wiki/Dimethylheptylpyran" title="Dimethylheptylpyran">Dimethylheptylpyran</a></li> <li><a href="/wiki/Docosatetraenoylethanolamide" title="Docosatetraenoylethanolamide">DEA</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Epigallocatechin_gallate" title="Epigallocatechin gallate">EGCG</a></li> <li><a href="/wiki/Catechin" title="Catechin">Epicatechin</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">Gallocatechol (gallocatechin)</a></li> <li><a href="/wiki/Honokiol" title="Honokiol">Honokiol</a></li> <li><a href="/wiki/HU-210" title="HU-210">HU-210</a></li> <li><a href="/wiki/JWH-007" title="JWH-007">JWH-007</a></li> <li><a href="/wiki/JWH-015" title="JWH-015">JWH-015</a></li> <li><a href="/wiki/JWH-018" title="JWH-018">JWH-018</a></li> <li><a href="/wiki/JWH-073" title="JWH-073">JWH-073</a></li> <li><a href="/wiki/Kavain" title="Kavain">Kavain</a></li> <li><a href="/wiki/L-759,633" title="L-759,633">L-759,633</a></li> <li><a href="/wiki/Levonantradol" title="Levonantradol">Levonantradol</a></li> <li><a href="/wiki/Menabitan" title="Menabitan">Menabitan</a></li> <li><a href="/wiki/Nabilone" title="Nabilone">Nabilone</a></li> <li><a href="/wiki/Nabitan" title="Nabitan">Nabitan</a></li> <li><a href="/wiki/N-Arachidonoyl_dopamine" title="N-Arachidonoyl dopamine">NADA</a></li> <li><a href="/wiki/O-1812" title="O-1812">O-1812</a></li> <li><a href="/wiki/Oleamide" title="Oleamide">Oleamide</a></li> <li><a href="/wiki/Pravadoline" title="Pravadoline">Pravadoline</a></li> <li><a href="/wiki/Serinolamide_A" title="Serinolamide A">Serinolamide A</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">THC (dronabinol)</a></li> <li><a href="/wiki/UR-144" title="UR-144">UR-144</a></li> <li><a href="/wiki/WIN_55,212-2" title="WIN 55,212-2">WIN 55,212-2</a></li> <li><a href="/wiki/Yangonin" title="Yangonin">Yangonin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Inverse agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/wiki/INV-202" class="mw-redirect" title="INV-202">INV-202</a></li> <li><a href="/wiki/Monlunabant" title="Monlunabant">Monlunabant</a></li> <li><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a></li> <li><a href="/wiki/Surinabant" title="Surinabant">Surinabant</a></li> <li><a href="/wiki/Taranabant" title="Taranabant">Taranabant</a></li> <li><a href="/wiki/TM-38837" title="TM-38837">TM-38837</a></li> <li><a href="/wiki/Zevaquenabant" title="Zevaquenabant">Zevaquenabant</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AM-6545" title="AM-6545">AM-6545</a></li> <li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Cannabigerol" title="Cannabigerol">Cannabigerol</a></li> <li><a href="/wiki/Drinabant" title="Drinabant">Drinabant</a></li> <li><a href="/wiki/Falcarinol" title="Falcarinol">Falcarinol (carotatoxin)</a></li> <li><a href="/wiki/Hemopressin" title="Hemopressin">Hemopressin</a></li> <li><a href="/wiki/Ibipinabant" title="Ibipinabant">Ibipinabant</a></li> <li><a href="/wiki/LY-320,135" title="LY-320,135">LY-320,135</a></li> <li><a href="/wiki/MK-9470" title="MK-9470">MK-9470</a></li> <li><a href="/wiki/NESS-0327" title="NESS-0327">NESS-0327</a></li> <li><a href="/wiki/O-2050" title="O-2050">O-2050</a></li> <li><a href="/wiki/Otenabant" title="Otenabant">Otenabant</a></li> <li><a href="/wiki/PF-514273" title="PF-514273">PF-514273</a></li> <li><a href="/wiki/PipISB" title="PipISB">PipISB</a></li> <li><a href="/wiki/Rosonabant" title="Rosonabant">Rosonabant</a></li> <li><a href="/w/index.php?title=Selonabant&action=edit&redlink=1" class="new" title="Selonabant (page does not exist)">Selonabant</a></li> <li><a href="/wiki/Tetrahydrocannabivarin" title="Tetrahydrocannabivarin">THCV</a></li> <li><a href="/wiki/VCHSR" title="VCHSR">VCHSR</a></li> <li><a href="/wiki/Virodhamine" title="Virodhamine">Virodhamine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Cannabinoid_receptor_type_2" class="mw-redirect" title="Cannabinoid receptor type 2"><abbr title="Cannabinoid receptor type 2">CB<sub>2</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cannabinoid receptor type 2</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Arachidonoylglycerol" title="2-Arachidonoylglycerol">2-AG</a></li> <li><a href="/wiki/2-Arachidonyl_glyceryl_ether" title="2-Arachidonyl glyceryl ether">2-AGE (noladin ether)</a></li> <li><a href="/wiki/3,3%27-Diindolylmethane" title="3,3'-Diindolylmethane">3,3'-Diindolylmethane</a></li> <li><a href="/wiki/4-O-Methylhonokiol" title="4-O-Methylhonokiol">4-O-Methylhonokiol</a></li> <li><a href="/wiki/Amyrin" title="Amyrin">α-Amyrin · β-Amyrin</a></li> <li><a href="/wiki/A-796,260" title="A-796,260">A-796,260</a></li> <li><a href="/wiki/A-834,735" title="A-834,735">A-834,735</a></li> <li><a href="/wiki/A-836,339" title="A-836,339">A-836,339</a></li> <li><a href="/w/index.php?title=AM-1172&action=edit&redlink=1" class="new" title="AM-1172 (page does not exist)">AM-1172</a></li> <li><a href="/wiki/AM-1221" title="AM-1221">AM-1221</a></li> <li><a href="/wiki/AM-1235" title="AM-1235">AM-1235</a></li> <li><a href="/wiki/AM-1241" title="AM-1241">AM-1241</a></li> <li><a href="/wiki/AM-2232" title="AM-2232">AM-2232</a></li> <li><a href="/wiki/Anandamide" title="Anandamide">Anandamide</a></li> <li><a href="/wiki/AZ-11713908" title="AZ-11713908">AZ-11713908</a></li> <li><a href="/wiki/Cannabinol" title="Cannabinol">Cannabinol</a></li> <li><a href="/wiki/Caryophyllene" title="Caryophyllene">Caryophyllene</a></li> <li><a href="/wiki/CB-13" title="CB-13">CB-13</a></li> <li><a href="/wiki/CBS-0550" title="CBS-0550">CBS-0550</a></li> <li><a href="/wiki/CP_55,940" title="CP 55,940">CP 55,940</a></li> <li><a href="/wiki/GW-405,833" title="GW-405,833">GW-405,833 (L-768,242)</a></li> <li><a href="/wiki/GW-842,166X" title="GW-842,166X">GW-842,166X</a></li> <li><a href="/wiki/HU-308" class="mw-redirect" title="HU-308">HU-308</a></li> <li><a href="/wiki/JTE_7-31" title="JTE 7-31">JTE 7-31</a></li> <li><a href="/wiki/JWH-007" title="JWH-007">JWH-007</a></li> <li><a href="/wiki/JWH-015" title="JWH-015">JWH-015</a></li> <li><a href="/wiki/JWH-018" title="JWH-018">JWH-018</a></li> <li><a href="/w/index.php?title=JWH-73&action=edit&redlink=1" class="new" title="JWH-73 (page does not exist)">JWH-73</a></li> <li><a href="/wiki/JWH-133" title="JWH-133">JWH-133</a></li> <li><a href="/wiki/L-759,633" title="L-759,633">L-759,633</a></li> <li><a href="/wiki/L-759,656" title="L-759,656">L-759,656</a></li> <li><a href="/wiki/Lenabasum" title="Lenabasum">Lenabasum (anabasum)</a></li> <li><a href="/wiki/Magnolol" title="Magnolol">Magnolol</a></li> <li><a href="/wiki/MDA-19" title="MDA-19">MDA-19</a></li> <li><a href="/wiki/Nabitan" title="Nabitan">Nabitan</a></li> <li><a href="/wiki/N-Arachidonoyl_dopamine" title="N-Arachidonoyl dopamine">NADA</a></li> <li><a href="/wiki/Olorinab" title="Olorinab">Olorinab (APD-371)</a></li> <li><a href="/wiki/PF-03550096" title="PF-03550096">PF-03550096</a></li> <li><a href="/wiki/S-444,823" title="S-444,823">S-444,823</a></li> <li><a href="/wiki/SER-601" title="SER-601">SER-601</a></li> <li><a href="/wiki/Serinolamide_A" title="Serinolamide A">Serinolamide A</a></li> <li><a href="/wiki/UR-144" title="UR-144">UR-144</a></li> <li><a href="/wiki/Tedalinab" title="Tedalinab">Tedalinab</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">THC (dronabinol)</a></li> <li><a href="/wiki/Tetrahydrocannabivarin" title="Tetrahydrocannabivarin">THCV</a></li> <li><a href="/w/index.php?title=Tetrahydromagnolol&action=edit&redlink=1" class="new" title="Tetrahydromagnolol (page does not exist)">Tetrahydromagnolol</a></li> <li><a href="/wiki/Virodhamine" title="Virodhamine">Virodhamine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4-O-Methylhonokiol" title="4-O-Methylhonokiol">4-O-Methylhonokiol</a></li> <li><a href="/wiki/AM-630" title="AM-630">AM-630</a></li> <li><a href="/wiki/BML-190" title="BML-190">BML-190</a></li> <li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Honokiol" title="Honokiol">Honokiol</a></li> <li><a href="/wiki/JTE-907" title="JTE-907">JTE-907</a></li> <li><a href="/wiki/SR-144,528" title="SR-144,528">SR-144,528</a></li> <li><a href="/wiki/WIN_54,461" title="WIN 54,461">WIN 54,461</a></li> <li><a href="/wiki/WIN_56,098" title="WIN 56,098">WIN 56,098</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/NAGly_receptor" title="NAGly receptor"><abbr title="N-Arachidonyl glycine receptor">NAGly</abbr><br />(<abbr title="G protein-coupled receptor 18">GPR18</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abnormal_cannabidiol" title="Abnormal cannabidiol">Abnormal cannabidiol</a></li> <li><a href="/wiki/Arachidonylcyclopropylamide" title="Arachidonylcyclopropylamide">ACPA</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM251</a></li> <li><a href="/wiki/Anandamide" title="Anandamide">Anandamide</a></li> <li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/N-Arachidonylglycine" title="N-Arachidonylglycine">NADGly</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">THC (dronabinol)</a></li> <li><a href="/wiki/O-1602" title="O-1602">O-1602</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PSB-CB5" title="PSB-CB5">PSB-CB5</a></li> <li><a href="/wiki/O-1918" title="O-1918">O-1918</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><abbr title="G protein-coupled receptor 55"><a href="/wiki/GPR55" title="GPR55">GPR55</a></abbr></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Arachidonyl_glyceryl_ether" title="2-Arachidonyl glyceryl ether">2-AGE (noladin ether)</a></li> <li><a href="/w/index.php?title=2-Arachidonoyl_lysophosphatidylinositol&action=edit&redlink=1" class="new" title="2-Arachidonoyl lysophosphatidylinositol (page does not exist)">2-ALPI</a></li> <li><a href="/wiki/Abnormal_cannabidiol" title="Abnormal cannabidiol">Abnormal cannabidiol</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/w/index.php?title=CID1011163&action=edit&redlink=1" class="new" title="CID1011163 (page does not exist)">CID1011163</a></li> <li><a href="/w/index.php?title=CID1252842&action=edit&redlink=1" class="new" title="CID1252842 (page does not exist)">CID1252842</a></li> <li><a href="/w/index.php?title=CID1792579&action=edit&redlink=1" class="new" title="CID1792579 (page does not exist)">CID1792579</a></li> <li><a href="/wiki/CP_55,940" title="CP 55,940">CP 55,940</a></li> <li><a href="/w/index.php?title=GSK-494581A&action=edit&redlink=1" class="new" title="GSK-494581A (page does not exist)">GSK-494581A</a></li> <li><a href="/wiki/Lysophosphatidylinositol" title="Lysophosphatidylinositol">Lysophosphatidylinositol</a></li> <li><a href="/w/index.php?title=ML-184&action=edit&redlink=1" class="new" title="ML-184 (page does not exist)">ML-184</a></li> <li><a href="/w/index.php?title=ML-185&action=edit&redlink=1" class="new" title="ML-185 (page does not exist)">ML-185</a></li> <li><a href="/w/index.php?title=ML-186&action=edit&redlink=1" class="new" title="ML-186 (page does not exist)">ML-186</a></li> <li><a href="/wiki/O-1602" title="O-1602">O-1602</a></li> <li><a href="/wiki/Oleoylethanolamide" title="Oleoylethanolamide">Oleoylethanolamide</a></li> <li><a href="/wiki/Palmitoylethanolamide" title="Palmitoylethanolamide">Palmitoylethanolamide</a></li> <li><a href="/wiki/Tetrahydrocannabinol" title="Tetrahydrocannabinol">THC (dronabinol)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/CID-16020046" class="mw-redirect" title="CID-16020046">CID-16020046</a></li> <li><a href="/w/index.php?title=ML-191&action=edit&redlink=1" class="new" title="ML-191 (page does not exist)">ML-191</a></li> <li><a href="/w/index.php?title=ML-192&action=edit&redlink=1" class="new" title="ML-192 (page does not exist)">ML-192</a></li> <li><a href="/w/index.php?title=ML-193&action=edit&redlink=1" class="new" title="ML-193 (page does not exist)">ML-193</a></li> <li><a href="/wiki/O-1918" title="O-1918">O-1918</a></li> <li><a href="/wiki/PSB-SB-487" title="PSB-SB-487">PSB-SB-487</a></li> <li><a href="/wiki/PSB-SB-1202" title="PSB-SB-1202">PSB-SB-1202</a></li> <li><a href="/w/index.php?title=PSB-SB-1203&action=edit&redlink=1" class="new" title="PSB-SB-1203 (page does not exist)">PSB-SB-1203</a></li> <li><a href="/w/index.php?title=Tetrahydromagnolol&action=edit&redlink=1" class="new" title="Tetrahydromagnolol (page does not exist)">Tetrahydromagnolol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><abbr title="G protein-coupled receptor 119"><a href="/wiki/GPR119" title="GPR119">GPR119</a></abbr></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Agonists" scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Oleoylglycerol" title="2-Oleoylglycerol">2-Oleoylglycerol</a></li> <li><a href="/wiki/Anandamide" title="Anandamide">Anandamide</a></li> <li><a href="/w/index.php?title=APD668&action=edit&redlink=1" class="new" title="APD668 (page does not exist)">APD668</a></li> <li><a href="/wiki/AR-231,453" title="AR-231,453">AR-231,453</a></li> <li><a href="/w/index.php?title=AS-1269574&action=edit&redlink=1" class="new" title="AS-1269574 (page does not exist)">AS-1269574</a></li> <li><a href="/w/index.php?title=MBX-2982&action=edit&redlink=1" class="new" title="MBX-2982 (page does not exist)">MBX-2982</a></li> <li><a href="/w/index.php?title=N-Oleoyldopamine&action=edit&redlink=1" class="new" title="N-Oleoyldopamine (page does not exist)">N-Oleoyldopamine</a></li> <li><a href="/wiki/Oleoylethanolamide" title="Oleoylethanolamide">Oleoylethanolamide</a></li> <li><a href="/w/index.php?title=Olvanil&action=edit&redlink=1" class="new" title="Olvanil (page does not exist)">Olvanil</a></li> <li><a href="/wiki/PSN-375,963" title="PSN-375,963">PSN-375,963</a></li> <li><a href="/wiki/PSN-632,408" title="PSN-632,408">PSN-632,408</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Endocannabinoid_transporter" title="Endocannabinoid transporter">Transporter</a><br /><span class="nobold">(<a href="/wiki/Reuptake_modulator" title="Reuptake modulator">modulators</a>)</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="eCBTsTooltip_Endocannabinoid_transporter" scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Endocannabinoid_transporter" title="Endocannabinoid transporter"><abbr title="Endocannabinoid transporter">eCBTs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Endocannabinoid transporter</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/w/index.php?title=5%27-DMH-CBD&action=edit&redlink=1" class="new" title="5'-DMH-CBD (page does not exist)">5'-DMH-CBD</a></li> <li><a href="/wiki/AM404" title="AM404">AM-404</a></li> <li><a href="/w/index.php?title=AM-1172&action=edit&redlink=1" class="new" title="AM-1172 (page does not exist)">AM-1172</a></li> <li><a href="/wiki/Arachidonoyl_serotonin" title="Arachidonoyl serotonin">Arachidonoyl serotonin</a></li> <li><a href="/w/index.php?title=Arvanil&action=edit&redlink=1" class="new" title="Arvanil (page does not exist)">Arvanil</a></li> <li><a href="/wiki/Cannabidiol" title="Cannabidiol">Cannabidiol</a></li> <li><a href="/wiki/Guineesine" title="Guineesine">Guineensine</a></li> <li><a href="/wiki/LY-2183240" title="LY-2183240">LY-2183240</a></li> <li><a href="/w/index.php?title=O-2093&action=edit&redlink=1" class="new" title="O-2093 (page does not exist)">O-2093</a></li> <li><a href="/w/index.php?title=OMDM-2&action=edit&redlink=1" class="new" title="OMDM-2 (page does not exist)">OMDM-2</a></li> <li><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol (acetaminophen)</a></li> <li><a href="/w/index.php?title=SB-FI-26&action=edit&redlink=1" class="new" title="SB-FI-26 (page does not exist)">SB-FI-26</a></li> <li><a href="/w/index.php?title=UCM-707&action=edit&redlink=1" class="new" title="UCM-707 (page does not exist)">UCM-707</a></li> <li><a href="/wiki/URB597" class="mw-redirect" title="URB597">URB-597</a></li> <li><a href="/wiki/VDM-11" title="VDM-11">VDM-11</a></li> <li><a href="/w/index.php?title=WOBE490&action=edit&redlink=1" class="new" title="WOBE490 (page does not exist)">WOBE490</a></li> <li><a href="/w/index.php?title=WOBE491&action=edit&redlink=1" class="new" title="WOBE491 (page does not exist)">WOBE491</a></li> <li><a href="/w/index.php?title=WOBE492&action=edit&redlink=1" class="new" title="WOBE492 (page does not exist)">WOBE492</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Enzyme" title="Enzyme">Enzyme</a><br /><span class="nobold">(<a href="/wiki/Enzyme_modulator" title="Enzyme modulator">modulators</a>)</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Fatty_acid_amide_hydrolase" class="mw-redirect" title="Fatty acid amide hydrolase"><abbr title="Fatty acid amide hydrolase">FAAH</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Fatty acid amide hydrolase</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/4-Nonylphenylboronic_acid" title="4-Nonylphenylboronic acid">4-Nonylphenylboronic acid</a></li> <li><a href="/wiki/Arachidonyl_trifluoromethyl_ketone" title="Arachidonyl trifluoromethyl ketone">AACOCF<sub>3</sub></a></li> <li><a href="/wiki/AM404" title="AM404">AM-404</a></li> <li><a href="/wiki/Arachidonoyl_serotonin" title="Arachidonoyl serotonin">Arachidonoyl serotonin</a></li> <li><a href="/wiki/BIA_10-2474" title="BIA 10-2474">BIA 10-2474</a></li> <li><a href="/wiki/Biochanin_A" title="Biochanin A">Biochanin A</a></li> <li><a href="/wiki/Genistein" title="Genistein">Genistein</a></li> <li><a href="/wiki/IDFP" title="IDFP">IDFP</a></li> <li><a href="/w/index.php?title=JNJ-1661010&action=edit&redlink=1" class="new" title="JNJ-1661010 (page does not exist)">JNJ-1661010</a></li> <li><a href="/wiki/JNJ-42165279" title="JNJ-42165279">JNJ-42165279</a></li> <li><a href="/wiki/JZL195" title="JZL195">JZL-195</a></li> <li><a href="/wiki/Kaempferol" title="Kaempferol">Kaempferol</a></li> <li><a href="/wiki/LY-2183240" title="LY-2183240">LY-2183240</a></li> <li><a href="/wiki/Methoxy_arachidonyl_fluorophosphonate" title="Methoxy arachidonyl fluorophosphonate">MAFP</a></li> <li><a href="/w/index.php?title=Palmitoylisopropylamide&action=edit&redlink=1" class="new" title="Palmitoylisopropylamide (page does not exist)">Palmitoylisopropylamide</a></li> <li><a href="/wiki/Paracetamol" title="Paracetamol">Paracetamol (acetaminophen)</a></li> <li><a href="/wiki/PF-3845" title="PF-3845">PF-3845</a></li> <li><a href="/w/index.php?title=PF-750&action=edit&redlink=1" class="new" title="PF-750 (page does not exist)">PF-750</a></li> <li><a href="/wiki/Redafamdastat" title="Redafamdastat">Redafamdastat (JZP-150, PF-04457845)</a></li> <li><a href="/w/index.php?title=SA-47&action=edit&redlink=1" class="new" title="SA-47 (page does not exist)">SA-47</a></li> <li><a href="/w/index.php?title=SA-57&action=edit&redlink=1" class="new" title="SA-57 (page does not exist)">SA-57</a></li> <li><a href="/w/index.php?title=TAK_21d&action=edit&redlink=1" class="new" title="TAK 21d (page does not exist)">TAK 21d</a></li> <li><a href="/w/index.php?title=TC-F_2&action=edit&redlink=1" class="new" title="TC-F 2 (page does not exist)">TC-F 2</a></li> <li><a href="/w/index.php?title=UCM710&action=edit&redlink=1" class="new" title="UCM710 (page does not exist)">UCM710</a></li> <li><a href="/wiki/URB597" class="mw-redirect" title="URB597">URB-597</a></li></ul> <ul><li><b>Activators:</b> <a href="/w/index.php?title=PDP-EA&action=edit&redlink=1" class="new" title="PDP-EA (page does not exist)">PDP-EA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><a href="/wiki/Monoacylglycerol_lipase" title="Monoacylglycerol lipase">MAGL</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/w/index.php?title=ABX-1431&action=edit&redlink=1" class="new" title="ABX-1431 (page does not exist)">ABX-1431</a></li> <li><a href="/wiki/IDFP" title="IDFP">IDFP</a></li> <li><a href="/w/index.php?title=JJKK_048&action=edit&redlink=1" class="new" title="JJKK 048 (page does not exist)">JJKK 048</a></li> <li><a href="/w/index.php?title=JW_642&action=edit&redlink=1" class="new" title="JW 642 (page does not exist)">JW 642</a></li> <li><a href="/wiki/JZL184" title="JZL184">JZL-184</a></li> <li><a href="/wiki/JZL195" title="JZL195">JZL-195</a></li> <li><a href="/w/index.php?title=JZP-361&action=edit&redlink=1" class="new" title="JZP-361 (page does not exist)">JZP-361</a></li> <li><a href="/w/index.php?title=KML_29&action=edit&redlink=1" class="new" title="KML 29 (page does not exist)">KML 29</a></li> <li><a href="/wiki/Methoxy_arachidonyl_fluorophosphonate" title="Methoxy arachidonyl fluorophosphonate">MAFP</a></li> <li><a href="/w/index.php?title=MJN110&action=edit&redlink=1" class="new" title="MJN110 (page does not exist)">MJN110</a></li> <li><a href="/w/index.php?title=N-Arachidonoylmaleimide&action=edit&redlink=1" class="new" title="N-Arachidonoylmaleimide (page does not exist)">NAM</a></li> <li><a href="/w/index.php?title=Pristimerin&action=edit&redlink=1" class="new" title="Pristimerin (page does not exist)">Pristimerin</a></li> <li><a href="/wiki/URB602" title="URB602">URB-602</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><abbr title="alpha/beta-Hydrolase domain containing 6"><a href="/wiki/ABHD6" title="ABHD6">ABHD6</a></abbr></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/w/index.php?title=JZP-169&action=edit&redlink=1" class="new" title="JZP-169 (page does not exist)">JZP-169</a></li> <li><a href="/w/index.php?title=JZP-430&action=edit&redlink=1" class="new" title="JZP-430 (page does not exist)">JZP-430</a></li> <li><a href="/w/index.php?title=KT182&action=edit&redlink=1" class="new" title="KT182 (page does not exist)">KT182</a></li> <li><a href="/w/index.php?title=KT185&action=edit&redlink=1" class="new" title="KT185 (page does not exist)">KT185</a></li> <li><a href="/w/index.php?title=KT195&action=edit&redlink=1" class="new" title="KT195 (page does not exist)">KT195</a></li> <li><a href="/w/index.php?title=KT203&action=edit&redlink=1" class="new" title="KT203 (page does not exist)">KT203</a></li> <li><a href="/w/index.php?title=LEI-106&action=edit&redlink=1" class="new" title="LEI-106 (page does not exist)">LEI-106</a></li> <li><a href="/w/index.php?title=ML294&action=edit&redlink=1" class="new" title="ML294 (page does not exist)">ML294</a></li> <li><a href="/w/index.php?title=ML295&action=edit&redlink=1" class="new" title="ML295 (page does not exist)">ML295</a></li> <li><a href="/w/index.php?title=ML296&action=edit&redlink=1" class="new" title="ML296 (page does not exist)">ML296</a></li> <li><a href="/w/index.php?title=UCM710&action=edit&redlink=1" class="new" title="UCM710 (page does not exist)">UCM710</a></li> <li><a href="/w/index.php?title=WWL-70&action=edit&redlink=1" class="new" title="WWL-70 (page does not exist)">WWL-70</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:4em;;text-align:center;"><abbr title="alpha/beta-Hydrolase domain containing 12"><a href="/wiki/ABHD12" title="ABHD12">ABHD12</a></abbr></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b>Inhibitors:</b> <a href="/wiki/Betulinic_acid" title="Betulinic acid">Betulinic acid</a></li> <li><a href="/wiki/Maslinic_acid" title="Maslinic acid">Maslinic acid</a></li> <li><a href="/wiki/Methoxy_arachidonyl_fluorophosphonate" title="Methoxy arachidonyl fluorophosphonate">MAFP</a></li> <li><a href="/wiki/Oleanolic_acid" title="Oleanolic acid">Oleanolic acid</a></li> <li><a href="/wiki/Orlistat" title="Orlistat">Orlistat (tetrahydrolipstatin)</a></li> <li><a href="/wiki/Ursolic_acid" title="Ursolic acid">Ursolic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>Precursors:</b> <a href="/wiki/Phosphatidylethanolamine" title="Phosphatidylethanolamine">Phosphatidylethanolamine</a></li> <li><a href="/wiki/N-Acylphosphatidylethanolamine" title="N-Acylphosphatidylethanolamine">NAPE</a></li> <li><a href="/wiki/Diglyceride" title="Diglyceride">Diacylglycerol</a></li></ul> <ul><li><b>Others:</b> <a href="/w/index.php?title=2-Palmitoylglycerol&action=edit&redlink=1" class="new" title="2-Palmitoylglycerol (page does not exist)">2-PG</a> <i>(directly potentiates activity of 2-AG at CB<sub>1</sub> receptor)</i></li> <li><a href="/w/index.php?title=ARN-272&action=edit&redlink=1" class="new" title="ARN-272 (page does not exist)">ARN-272</a> <i>(FAAH-like anandamide transporter inhibitor)</i></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><i> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></dd> <dd><i> <a href="/wiki/Template:Cannabinoids" title="Template:Cannabinoids">Cannabinoids</a> (cannabinoids by structure)</i></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Ion_channel_modulators" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Ion_channel_modulators" title="Template:Ion channel modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Ion_channel_modulators" title="Template talk:Ion channel modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Ion_channel_modulators" title="Special:EditPage/Template:Ion channel modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Ion_channel_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Channel_modulator" title="Channel modulator">Ion channel modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Calcium_channel" title="Calcium channel">Calcium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="VDCCsTooltip_Voltage-dependent_calcium_channels" scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-dependent_calcium_channels" class="mw-redirect" title="Voltage-dependent calcium channels"><abbr title="Voltage-dependent calcium channels">VDCCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-dependent calcium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <i><a href="/wiki/Dihydropyridine" class="mw-redirect" title="Dihydropyridine">Dihydropyridines</a>:</i> <a href="/wiki/Amlodipine" title="Amlodipine">Amlodipine</a></li> <li><a href="/wiki/Aranidipine" title="Aranidipine">Aranidipine</a></li> <li><a href="/wiki/Azelnidipine" title="Azelnidipine">Azelnidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Barnidipine</a></li> <li><a href="/wiki/Clevidipine" title="Clevidipine">Clevidipine</a></li> <li><a href="/w/index.php?title=Cronidipine&action=edit&redlink=1" class="new" title="Cronidipine (page does not exist)">Cronidipine</a></li> <li><a href="/wiki/Darodipine" title="Darodipine">Darodipine</a></li> <li><a href="/w/index.php?title=Dexniguldipine&action=edit&redlink=1" class="new" title="Dexniguldipine (page does not exist)">Dexniguldipine</a></li> <li><a href="/w/index.php?title=Elgodipine&action=edit&redlink=1" class="new" title="Elgodipine (page does not exist)">Elgodipine</a></li> <li><a href="/w/index.php?title=Elnadipine&action=edit&redlink=1" class="new" title="Elnadipine (page does not exist)">Elnadipine</a></li> <li><a href="/wiki/Felodipine" title="Felodipine">Felodipine</a></li> <li><a href="/w/index.php?title=Flordipine&action=edit&redlink=1" class="new" title="Flordipine (page does not exist)">Flordipine</a></li> <li><a href="/w/index.php?title=Furnidipine&action=edit&redlink=1" class="new" title="Furnidipine (page does not exist)">Furnidipine</a></li> <li><a href="/w/index.php?title=Iganidipine&action=edit&redlink=1" class="new" title="Iganidipine (page does not exist)">Iganidipine</a></li> <li><a href="/wiki/Isradipine" title="Isradipine">Isradipine</a></li> <li><a href="/wiki/Lacidipine" title="Lacidipine">Lacidipine</a></li> <li><a href="/w/index.php?title=Lemildipine&action=edit&redlink=1" class="new" title="Lemildipine (page does not exist)">Lemildipine</a></li> <li><a href="/wiki/Lercanidipine" title="Lercanidipine">Lercanidipine</a></li> <li><a href="/wiki/Levamlodipine" title="Levamlodipine">Levamlodipine</a></li> <li><a href="/w/index.php?title=Levniguldipine&action=edit&redlink=1" class="new" title="Levniguldipine (page does not exist)">Levniguldipine</a></li> <li><a href="/wiki/Manidipine" title="Manidipine">Manidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Mepirodipine</a></li> <li><a href="/w/index.php?title=Mesudipine&action=edit&redlink=1" class="new" title="Mesudipine (page does not exist)">Mesudipine</a></li> <li><a href="/wiki/Nicardipine" title="Nicardipine">Nicardipine</a></li> <li><a href="/wiki/Nifedipine" title="Nifedipine">Nifedipine</a></li> <li><a href="/wiki/Niguldipine" title="Niguldipine">Niguldipine</a></li> <li><a href="/wiki/Niludipine" title="Niludipine">Niludipine</a></li> <li><a href="/wiki/Nilvadipine" title="Nilvadipine">Nilvadipine</a></li> <li><a href="/wiki/Nimodipine" title="Nimodipine">Nimodipine</a></li> <li><a href="/wiki/Nisoldipine" title="Nisoldipine">Nisoldipine</a></li> <li><a href="/wiki/Nitrendipine" title="Nitrendipine">Nitrendipine</a></li> <li><a href="/w/index.php?title=Olradipine&action=edit&redlink=1" class="new" title="Olradipine (page does not exist)">Olradipine</a></li> <li><a href="/wiki/Oxodipine" title="Oxodipine">Oxodipine</a></li> <li><a href="/w/index.php?title=Palonidipine&action=edit&redlink=1" class="new" title="Palonidipine (page does not exist)">Palonidipine</a></li> <li><a href="/wiki/Pranidipine" title="Pranidipine">Pranidipine</a></li> <li><a href="/wiki/Riodipine" title="Riodipine">Ryodipine (riodipine)</a></li> <li><a href="/w/index.php?title=Sagandipine&action=edit&redlink=1" class="new" title="Sagandipine (page does not exist)">Sagandipine</a></li> <li><a href="/w/index.php?title=Sornidipine&action=edit&redlink=1" class="new" title="Sornidipine (page does not exist)">Sornidipine</a></li> <li><a href="/w/index.php?title=Teludipine&action=edit&redlink=1" class="new" title="Teludipine (page does not exist)">Teludipine</a></li> <li><a href="/w/index.php?title=Tiamdipine&action=edit&redlink=1" class="new" title="Tiamdipine (page does not exist)">Tiamdipine</a></li> <li><a href="/w/index.php?title=Trombodipine&action=edit&redlink=1" class="new" title="Trombodipine (page does not exist)">Trombodipine</a></li> <li><a href="/w/index.php?title=Vatanidipine&action=edit&redlink=1" class="new" title="Vatanidipine (page does not exist)">Vatanidipine</a>; <i><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a> derivatives:</i> <a href="/wiki/Clentiazem" title="Clentiazem">Clentiazem</a></li> <li><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a></li> <li><a href="/w/index.php?title=Iprotiazem&action=edit&redlink=1" class="new" title="Iprotiazem (page does not exist)">Iprotiazem</a></li> <li><a href="/w/index.php?title=Nictiazem&action=edit&redlink=1" class="new" title="Nictiazem (page does not exist)">Nictiazem</a></li> <li><a href="/w/index.php?title=Siratiazem&action=edit&redlink=1" class="new" title="Siratiazem (page does not exist)">Siratiazem</a>; <i><a href="/wiki/Arylalkylamine" title="Arylalkylamine">Phenylalkylamines</a>:</i> <a href="/wiki/Anipamil" title="Anipamil">Anipamil</a></li> <li><a href="/w/index.php?title=Dagapamil&action=edit&redlink=1" class="new" title="Dagapamil (page does not exist)">Dagapamil</a></li> <li><a href="/wiki/Devapamil" title="Devapamil">Devapamil</a></li> <li><a href="/w/index.php?title=Dexverapamil&action=edit&redlink=1" class="new" title="Dexverapamil (page does not exist)">Dexverapamil</a></li> <li><a href="/wiki/Emopamil" title="Emopamil">Emopamil</a></li> <li><a href="/w/index.php?title=Etripamil&action=edit&redlink=1" class="new" title="Etripamil (page does not exist)">Etripamil</a></li> <li><a href="/wiki/Falipamil" title="Falipamil">Falipamil</a></li> <li><a href="/wiki/Gallopamil" title="Gallopamil">Gallopamil</a></li> <li><a href="/w/index.php?title=Levemopamil&action=edit&redlink=1" class="new" title="Levemopamil (page does not exist)">Levemopamil</a></li> <li><a href="/w/index.php?title=Nexopamil&action=edit&redlink=1" class="new" title="Nexopamil (page does not exist)">Nexopamil</a></li> <li><a href="/wiki/Norverapamil" title="Norverapamil">Norverapamil</a></li> <li><a href="/w/index.php?title=Ronipamil&action=edit&redlink=1" class="new" title="Ronipamil (page does not exist)">Ronipamil</a></li> <li><a href="/wiki/Tiapamil" title="Tiapamil">Tiapamil</a></li> <li><a href="/wiki/Verapamil" title="Verapamil">Verapamil</a>; <i>Others:</i> <a href="/wiki/AH-1058" title="AH-1058">AH-1058</a></li> <li><a href="/w/index.php?title=Brinazarone&action=edit&redlink=1" class="new" title="Brinazarone (page does not exist)">Brinazarone</a></li> <li><a href="/wiki/Budiodarone" title="Budiodarone">Budiodarone</a></li> <li><a href="/wiki/Celivarone" title="Celivarone">Celivarone</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Fantofarone" title="Fantofarone">Fantofarone</a></li> <li><a href="/w/index.php?title=SR-33805&action=edit&redlink=1" class="new" title="SR-33805 (page does not exist)">SR-33805</a></li> <li><a href="/wiki/Tetrahydropalmatine" title="Tetrahydropalmatine">Tetrahydropalmatine</a></li></ul> <ul><li><b><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N-type-selective</a>:</b> <a href="/wiki/%CE%A9-Conotoxin" class="mw-redirect" title="Ω-Conotoxin">ω-Conotoxins</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_GVIA&action=edit&redlink=1" class="new" title="Ω-Conotoxin GVIA (page does not exist)">ω-Conotoxin GVIA</a></li> <li><a href="/wiki/Caroverine" title="Caroverine">Caroverine</a></li> <li><a href="/w/index.php?title=Huwentoxin_XVI&action=edit&redlink=1" class="new" title="Huwentoxin XVI (page does not exist)">Huwentoxin XVI</a></li> <li><a href="/wiki/Leconotide" title="Leconotide">Leconotide (ω-conotoxin CVID)</a></li> <li><a href="/w/index.php?title=PD-173212&action=edit&redlink=1" class="new" title="PD-173212 (page does not exist)">PD-173212</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/w/index.php?title=Z160&action=edit&redlink=1" class="new" title="Z160 (page does not exist)">Z160</a></li> <li><a href="/wiki/Ziconotide" title="Ziconotide">Ziconotide (ω-conotoxin MVIIA)</a></li></ul> <ul><li><b><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P-type-selective</a>:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_IVA&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVA (page does not exist)">ω-Agatoxin IVA</a></li> <li><a href="/w/index.php?title=%CE%A9-Agatoxin_IVB&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVB (page does not exist)">ω-Agatoxin IVB</a></li></ul> <ul><li><b><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R-type-selective</a>:</b> <a href="/wiki/SNX-482" title="SNX-482">SNX-482</a></li></ul> <ul><li><b><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T-type-selective</a>:</b> <a href="/w/index.php?title=ABT-639&action=edit&redlink=1" class="new" title="ABT-639 (page does not exist)">ABT-639</a></li> <li><a href="/w/index.php?title=ML-218&action=edit&redlink=1" class="new" title="ML-218 (page does not exist)">ML-218</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=NNC_55-0396&action=edit&redlink=1" class="new" title="NNC 55-0396 (page does not exist)">NNC 55-0396</a></li> <li><a href="/w/index.php?title=ProTx_I&action=edit&redlink=1" class="new" title="ProTx I (page does not exist)">ProTx I</a></li> <li><a href="/w/index.php?title=Z944&action=edit&redlink=1" class="new" title="Z944 (page does not exist)">Z944</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><b>Non-selective:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_TK&action=edit&redlink=1" class="new" title="Ω-Agatoxin TK (page does not exist)">ω-Agatoxin TK</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_MVIIC&action=edit&redlink=1" class="new" title="Ω-Conotoxin MVIIC (page does not exist)">ω-Conotoxin MVIIC</a></li> <li><a href="/wiki/Benidipine" title="Benidipine">Benidipine</a></li> <li><a href="/wiki/Bepridil" title="Bepridil">Bepridil</a></li> <li><a href="/wiki/Cilnidipine" title="Cilnidipine">Cilnidipine</a></li> <li><a href="/wiki/Cinnarizine" title="Cinnarizine">Cinnarizine</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Efonidipine" title="Efonidipine">Efonidipine</a></li> <li><a href="/wiki/Flunarizine" title="Flunarizine">Flunarizine</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Levetiracetam" title="Levetiracetam">Levetiracetam</a></li> <li><a href="/wiki/Lomerizine" title="Lomerizine">Lomerizine</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/w/index.php?title=NP078585&action=edit&redlink=1" class="new" title="NP078585 (page does not exist)">NP078585</a></li> <li><a href="/wiki/Ruthenium_red" title="Ruthenium red">Ruthenium red</a></li> <li><a href="/wiki/TROX-1" title="TROX-1">TROX-1</a></li></ul> <ul><li><b><a href="/wiki/Voltage-dependent_calcium_channel#α2δ_Subunit" class="mw-redirect" title="Voltage-dependent calcium channel">α<sub>2</sub>δ subunit</a>-selective (<a href="/wiki/Gabapentinoid" title="Gabapentinoid">gabapentinoids</a>):</b> <a href="/wiki/4-Methylpregabalin" title="4-Methylpregabalin">4-Methylpregabalin</a></li> <li><a href="/wiki/Arbaclofen" class="mw-redirect" title="Arbaclofen">Arbaclofen</a></li> <li><a href="/wiki/Arbaclofen_placarbil" title="Arbaclofen placarbil">Arbaclofen placarbil</a></li> <li><a href="/wiki/Atagabalin" title="Atagabalin">Atagabalin</a></li> <li><a href="/wiki/Baclofen" title="Baclofen">Baclofen</a></li> <li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Imagabalin" title="Imagabalin">Imagabalin</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/w/index.php?title=PD-200,347&action=edit&redlink=1" class="new" title="PD-200,347 (page does not exist)">PD-200,347</a></li> <li><a href="/wiki/PD-217,014" title="PD-217,014">PD-217,014</a></li> <li><a href="/w/index.php?title=PD-299,685&action=edit&redlink=1" class="new" title="PD-299,685 (page does not exist)">PD-299,685</a></li> <li><a href="/wiki/Phenibut" title="Phenibut">Phenibut</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li></ul> <ul><li><b>Others/unsorted:</b> <a href="/wiki/Bencyclane" title="Bencyclane">Bencyclane</a></li> <li><a href="/wiki/Berbamine" title="Berbamine">Berbamine</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a href="/wiki/Canadine" title="Canadine">Canadine</a></li> <li><a href="/wiki/Carboxyamidotriazole" title="Carboxyamidotriazole">Carboxyamidotriazole</a></li> <li><a href="/wiki/Cycleanine" title="Cycleanine">Cycleanine</a></li> <li><a href="/wiki/Dauricine" title="Dauricine">Dauricine</a></li> <li><a href="/wiki/Dimeditiapramine" class="mw-redirect" title="Dimeditiapramine">Dimeditiapramine</a></li> <li><a href="/wiki/Diproteverine" title="Diproteverine">Diproteverine</a></li> <li><a href="/wiki/Enpiperate" title="Enpiperate">Enpiperate</a></li> <li><a href="/wiki/Eperisone" title="Eperisone">Eperisone</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Ethadione" title="Ethadione">Ethadione</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Fasudil" title="Fasudil">Fasudil</a></li> <li><a href="/wiki/Fendiline" title="Fendiline">Fendiline</a></li> <li><a href="/wiki/Fostedil" title="Fostedil">Fostedil</a></li> <li><a href="/wiki/Imepitoin" title="Imepitoin">Imepitoin</a></li> <li><a href="/wiki/JTV-519" title="JTV-519">JTV-519</a></li> <li><a href="/wiki/Lidoflazine" title="Lidoflazine">Lidoflazine</a></li> <li><a href="/wiki/Magnesium" title="Magnesium">Magnesium</a></li> <li><a href="/wiki/Manoalide" title="Manoalide">Manoalide</a></li> <li><a href="/wiki/Mesuximide" title="Mesuximide">Mesuximide</a></li> <li><a href="/wiki/Monatepil" title="Monatepil">Monatepil</a></li> <li><a href="/wiki/Naftopidil" title="Naftopidil">Naftopidil</a></li> <li><a href="/wiki/Ochratoxin_A" title="Ochratoxin A">Ochratoxin A</a></li> <li><a href="/wiki/Osthol" title="Osthol">Osthol</a></li> <li><a href="/wiki/Otilonium_bromide" title="Otilonium bromide">Otilonium bromide</a></li> <li><a href="/wiki/Paramethadione" title="Paramethadione">Paramethadione</a></li> <li><a href="/wiki/Phensuximide" title="Phensuximide">Phensuximide</a></li> <li><a href="/wiki/Pinaverium_bromide" title="Pinaverium bromide">Pinaverium bromide</a></li> <li><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a></li> <li><a href="/wiki/Rhynchophylline" title="Rhynchophylline">Rhynchophylline</a></li> <li><a href="/wiki/Sesamodil" title="Sesamodil">Sesamodil</a></li> <li><a href="/wiki/Silperisone" title="Silperisone">Silperisone</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Tetrandrine" title="Tetrandrine">Tetrandrine</a></li> <li><a href="/wiki/Tolperisone" title="Tolperisone">Tolperisone</a></li> <li><a href="/wiki/Trimethadione" title="Trimethadione">Trimethadione</a></li> <li><a href="/wiki/Valperinol" title="Valperinol">Valperinol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_opener" title="Calcium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <a href="/wiki/Bay_K8644" title="Bay K8644">Bay K8644</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Potassium_channel" title="Potassium channel">Potassium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_potassium_channels" class="mw-redirect" title="Voltage-gated potassium channels"><abbr title="Voltage-gated potassium channels">VGKCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated potassium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3,4-Diaminopyridine" class="mw-redirect" title="3,4-Diaminopyridine">3,4-Diaminopyridine (amifampridine)</a></li> <li><a href="/wiki/4-Aminopyridine" title="4-Aminopyridine">4-Aminopyridine (fampridine/dalfampridine)</a></li> <li><a href="/w/index.php?title=Adekalant&action=edit&redlink=1" class="new" title="Adekalant (page does not exist)">Adekalant</a></li> <li><a href="/wiki/Almokalant" title="Almokalant">Almokalant</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bretylium" title="Bretylium">Bretylium</a></li> <li><a href="/wiki/Bunaftine" title="Bunaftine">Bunaftine</a></li> <li><a href="/wiki/Charybdotoxin" title="Charybdotoxin">Charybdotoxin</a></li> <li><a href="/w/index.php?title=Clamikalant&action=edit&redlink=1" class="new" title="Clamikalant (page does not exist)">Clamikalant</a></li> <li><a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/w/index.php?title=Dalazatide&action=edit&redlink=1" class="new" title="Dalazatide (page does not exist)">Dalazatide</a></li> <li><a href="/wiki/Dendrotoxin" title="Dendrotoxin">Dendrotoxin</a></li> <li><a href="/wiki/Dofetilide" title="Dofetilide">Dofetilide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Hanatoxin" title="Hanatoxin">Hanatoxin</a></li> <li><a href="/wiki/HgeTx1" title="HgeTx1">HgeTx1</a></li> <li><a href="/wiki/HsTx1" title="HsTx1">HsTx1</a></li> <li><a href="/wiki/Ibutilide" title="Ibutilide">Ibutilide</a></li> <li><a href="/w/index.php?title=Inakalant&action=edit&redlink=1" class="new" title="Inakalant (page does not exist)">Inakalant</a></li> <li><a href="/wiki/Kaliotoxin" title="Kaliotoxin">Kaliotoxin</a></li> <li><a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/wiki/Lolitrem_B" title="Lolitrem B">Lolitrem B</a></li> <li><a href="/wiki/Maurotoxin" title="Maurotoxin">Maurotoxin</a></li> <li><a href="/wiki/Nifekalant" title="Nifekalant">Nifekalant</a></li> <li><a href="/w/index.php?title=Notoxin&action=edit&redlink=1" class="new" title="Notoxin (page does not exist)">Notoxin</a></li> <li><a href="/wiki/Paxilline" title="Paxilline">Paxilline</a></li> <li><a href="/w/index.php?title=Pinokalant&action=edit&redlink=1" class="new" title="Pinokalant (page does not exist)">Pinokalant</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/w/index.php?title=ShK-186&action=edit&redlink=1" class="new" title="ShK-186 (page does not exist)">ShK-186</a></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Tedisamil" title="Tedisamil">Tedisamil</a></li> <li><a href="/w/index.php?title=Terikalant&action=edit&redlink=1" class="new" title="Terikalant (page does not exist)">Terikalant</a></li> <li><a href="/wiki/Tetraethylammonium" title="Tetraethylammonium">Tetraethylammonium</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/HERG" title="HERG">hERG</a> (KCNH2, K<sub>v</sub>11.1)-specific:</b> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/AmmTX3" title="AmmTX3">AmmTX3</a></li> <li><a href="/wiki/Astemizole" title="Astemizole">Astemizole</a></li> <li><a href="/wiki/Azaspiracid" title="Azaspiracid">Azaspiracid</a></li> <li><a href="/wiki/AZD1305" title="AZD1305">AZD1305</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bedaquiline" title="Bedaquiline">Bedaquiline</a></li> <li><a href="/wiki/BeKm-1_toxin" title="BeKm-1 toxin">BeKm-1</a></li> <li><a href="/wiki/BmTx3" title="BmTx3">BmTx3</a></li> <li><a href="/wiki/BRL-32872" title="BRL-32872">BRL-32872</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Cisapride" title="Cisapride">Cisapride</a></li> <li><a href="/wiki/Clarithromycin" title="Clarithromycin">Clarithromycin</a></li> <li><a href="/wiki/Darifenacin" title="Darifenacin">Darifenacin</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a></li> <li><a href="/wiki/Diallyl_trisulfide" title="Diallyl trisulfide">Diallyl trisulfide</a></li> <li><a href="/wiki/Domperidone" title="Domperidone">Domperidone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Ergtoxin" title="Ergtoxin">Ergtoxins</a></li> <li><a href="/wiki/Erythromycin" title="Erythromycin">Erythromycin</a></li> <li><a href="/wiki/Gigactonine" title="Gigactonine">Gigactonine</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Norpropoxyphene" title="Norpropoxyphene">Norpropoxyphene</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li> <li><a href="/wiki/PNU-282,987" title="PNU-282,987">PNU-282,987</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li> <li><a href="/wiki/Roxithromycin" title="Roxithromycin">Roxithromycin</a></li> <li><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></li> <li><a href="/wiki/Solifenacin" title="Solifenacin">Solifenacin</a></li> <li><a href="/wiki/Tamulotoxin" title="Tamulotoxin">Tamulotoxin</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Terfenadine" title="Terfenadine">Terfenadine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Tolterodine" title="Tolterodine">Tolterodine</a></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/w/index.php?title=XE-991&action=edit&redlink=1" class="new" title="XE-991 (page does not exist)">XE-991</a></li> <li><a href="/wiki/Ssm_spooky_toxin" title="Ssm spooky toxin">Spooky toxin (SsTx)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a></li> <li><a href="/wiki/Retigabine" title="Retigabine">Retigabine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Inwardly_rectifying_potassium_channel" class="mw-redirect" title="Inwardly rectifying potassium channel"><abbr title="Inwardly rectifying potassium channel">IRKs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Inwardly rectifying potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/wiki/Acetohexamide" title="Acetohexamide">Acetohexamide</a></li> <li><a href="/wiki/Carbutamide" title="Carbutamide">Carbutamide</a></li> <li><a href="/wiki/Chlorpropamide" title="Chlorpropamide">Chlorpropamide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide (glyburide)</a></li> <li><a href="/wiki/Glibornuride" title="Glibornuride">Glibornuride</a></li> <li><a href="/wiki/Glicaramide" title="Glicaramide">Glicaramide</a></li> <li><a href="/wiki/Gliclazide" title="Gliclazide">Gliclazide</a></li> <li><a href="/wiki/Glimepiride" title="Glimepiride">Glimepiride</a></li> <li><a href="/wiki/Glipizide" title="Glipizide">Glipizide</a></li> <li><a href="/wiki/Gliquidone" title="Gliquidone">Gliquidone</a></li> <li><a href="/wiki/Glisoxepide" title="Glisoxepide">Glisoxepide</a></li> <li><a href="/wiki/Glyclopyramide" title="Glyclopyramide">Glyclopyramide</a></li> <li><a href="/w/index.php?title=Glycyclamide&action=edit&redlink=1" class="new" title="Glycyclamide (page does not exist)">Glycyclamide</a></li> <li><a href="/wiki/Metahexamide" title="Metahexamide">Metahexamide</a></li> <li><a href="/wiki/Mitiglinide" title="Mitiglinide">Mitiglinide</a></li> <li><a href="/wiki/Nateglinide" title="Nateglinide">Nateglinide</a></li> <li><a href="/wiki/Repaglinide" title="Repaglinide">Repaglinide</a></li> <li><a href="/wiki/Tolazamide" title="Tolazamide">Tolazamide</a></li> <li><a href="/wiki/Tolbutamide" title="Tolbutamide">Tolbutamide</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/wiki/Barium" title="Barium">Barium</a></li> <li><a href="/wiki/Caramiphen" title="Caramiphen">Caramiphen</a></li> <li><a href="/wiki/Cloperastine" title="Cloperastine">Cloperastine</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Ifenprodil" title="Ifenprodil">Ifenprodil</a></li> <li><a href="/wiki/Tertiapin" title="Tertiapin">Tertiapin</a></li> <li><a href="/wiki/Tipepidine" title="Tipepidine">Tipepidine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/w/index.php?title=Aprikalim&action=edit&redlink=1" class="new" title="Aprikalim (page does not exist)">Aprikalim</a></li> <li><a href="/wiki/Bimakalim" title="Bimakalim">Bimakalim</a></li> <li><a href="/wiki/Cromakalim" title="Cromakalim">Cromakalim</a></li> <li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li> <li><a href="/w/index.php?title=Emakalim&action=edit&redlink=1" class="new" title="Emakalim (page does not exist)">Emakalim</a></li> <li><a href="/wiki/Levcromakalim" class="mw-redirect" title="Levcromakalim">Levcromakalim</a></li> <li><a href="/w/index.php?title=Mazokalim&action=edit&redlink=1" class="new" title="Mazokalim (page does not exist)">Mazokalim</a></li> <li><a href="/wiki/Minoxidil" title="Minoxidil">Minoxidil</a></li> <li><a href="/wiki/Minoxidil_sulfate" title="Minoxidil sulfate">Minoxidil sulfate</a></li> <li><a href="/w/index.php?title=Naminidil&action=edit&redlink=1" class="new" title="Naminidil (page does not exist)">Naminidil</a></li> <li><a href="/wiki/Nicorandil" title="Nicorandil">Nicorandil</a></li> <li><a href="/wiki/Pinacidil" title="Pinacidil">Pinacidil</a></li> <li><a href="/w/index.php?title=Rilmakalim&action=edit&redlink=1" class="new" title="Rilmakalim (page does not exist)">Rilmakalim</a></li> <li><a href="/w/index.php?title=Sarakalim&action=edit&redlink=1" class="new" title="Sarakalim (page does not exist)">Sarakalim</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/w/index.php?title=ML-297&action=edit&redlink=1" class="new" title="ML-297 (page does not exist)">ML-297 (VU0456810)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel"><abbr title="Calcium-activated potassium channel">K<sub>Ca</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/GAL-021" class="mw-redirect" title="GAL-021">GAL-021</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Rottlerin" title="Rottlerin">Rottlerin (mallotoxin)</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Tandem_pore_domain_potassium_channel" class="mw-redirect" title="Tandem pore domain potassium channel"><abbr title="Tandem pore domain potassium channel">K2Ps</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Tandem pore domain potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/12-O-Tetradecanoylphorbol-13-acetate" title="12-O-Tetradecanoylphorbol-13-acetate">12-O-Tetradecanoylphorbol-13-acetate</a></li> <li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Norfluoxetine" class="mw-redirect" title="Norfluoxetine">Norfluoxetine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Riluzole" title="Riluzole">Riluzole</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Sodium_channel" title="Sodium channel">Sodium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_sodium_channels" class="mw-redirect" title="Voltage-gated sodium channels"><abbr title="Voltage-gated sodium channels">VGSCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated sodium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Antianginals:</i> <a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li></ul> <ul><li><i>Antiarrhythmics (class I):</i> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Aprindine" title="Aprindine">Aprindine</a></li> <li><a href="/wiki/Disopyramide" title="Disopyramide">Disopyramide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Encainide" title="Encainide">Encainide</a></li> <li><a href="/wiki/Flecainide" title="Flecainide">Flecainide</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Lorajmine" title="Lorajmine">Lorajmine</a></li> <li><a href="/wiki/Lorcainide" title="Lorcainide">Lorcainide</a></li> <li><a href="/wiki/Mexiletine" title="Mexiletine">Mexiletine</a></li> <li><a href="/wiki/Moracizine" title="Moracizine">Moricizine</a></li> <li><a href="/wiki/Pilsicainide" title="Pilsicainide">Pilsicainide</a></li> <li><a href="/wiki/Prajmaline" title="Prajmaline">Prajmaline</a></li> <li><a href="/wiki/Procainamide" title="Procainamide">Procainamide</a></li> <li><a href="/wiki/Propafenone" title="Propafenone">Propafenone</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Sparteine" title="Sparteine">Sparteine</a></li> <li><a href="/wiki/Tocainide" title="Tocainide">Tocainide</a></li></ul> <ul><li><i>Anticonvulsants:</i> <a href="/w/index.php?title=Acetylpheneturide&action=edit&redlink=1" class="new" title="Acetylpheneturide (page does not exist)">Acetylpheneturide</a></li> <li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Cenobamate" title="Cenobamate">Cenobamate</a></li> <li><a href="/wiki/Chlorphenacemide" title="Chlorphenacemide">Chlorphenacemide</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Eslicarbazepine_acetate" title="Eslicarbazepine acetate">Eslicarbazepine acetate</a></li> <li><a href="/wiki/Ethotoin" title="Ethotoin">Ethotoin</a></li> <li><a href="/wiki/Fosphenytoin" title="Fosphenytoin">Fosphenytoin</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Lacosamide" title="Lacosamide">Lacosamide</a></li> <li><a href="/wiki/Licarbazepine" title="Licarbazepine">Licarbazepine</a></li> <li><a href="/wiki/Mephenytoin" title="Mephenytoin">Mephenytoin</a></li> <li><a href="/wiki/Oxcarbazepine" title="Oxcarbazepine">Oxcarbazepine</a></li> <li><a href="/wiki/Oxitriptyline" title="Oxitriptyline">Oxitriptyline</a></li> <li><a href="/wiki/Phenacemide" title="Phenacemide">Phenacemide</a></li> <li><a href="/wiki/Pheneturide" title="Pheneturide">Pheneturide</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/Rufinamide" title="Rufinamide">Rufinamide</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/wiki/Sodium_valproate" class="mw-redirect" title="Sodium valproate">Sodium valproate</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li> <li><a href="/wiki/Valproate_pivoxil" title="Valproate pivoxil">Valproate pivoxil</a></li> <li><a href="/wiki/Valproate_semisodium" class="mw-redirect" title="Valproate semisodium">Valproate semisodium</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li> <li><a href="/wiki/Valpromide" title="Valpromide">Valpromide</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><i>Local anesthetics:</i> <a href="/wiki/3-(p-Fluorobenzoyloxy)tropane" title="3-(p-Fluorobenzoyloxy)tropane"><i>p</i>FBT</a></li> <li><a href="/wiki/Amylocaine" title="Amylocaine">Amylocaine</a></li> <li><a href="/wiki/Articaine" title="Articaine">Articaine</a></li> <li><a href="/wiki/Benzocaine" title="Benzocaine">Benzocaine</a></li> <li><a href="/wiki/Bupivacaine" title="Bupivacaine">Bupivacaine</a> (<a href="/wiki/Levobupivacaine" title="Levobupivacaine">Levobupivacaine</a>, <a href="/wiki/Ropivacaine" title="Ropivacaine">Ropivacaine</a>)</li> <li><a href="/wiki/Butacaine" title="Butacaine">Butacaine</a></li> <li><a href="/wiki/Butamben" title="Butamben">Butamben</a></li> <li><a href="/wiki/Chloroprocaine" title="Chloroprocaine">Chloroprocaine</a></li> <li><a href="/wiki/Cinchocaine" title="Cinchocaine">Cinchocaine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Cyclomethycaine" title="Cyclomethycaine">Cyclomethycaine</a></li> <li><a href="/wiki/Dimethocaine" title="Dimethocaine">Dimethocaine</a></li> <li><a href="/wiki/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a></li> <li><a href="/wiki/Etidocaine" title="Etidocaine">Etidocaine</a></li> <li><a href="/wiki/Hexylcaine" title="Hexylcaine">Hexylcaine</a></li> <li><a href="/wiki/Iontocaine" title="Iontocaine">Iontocaine</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Mepivacaine" title="Mepivacaine">Mepivacaine</a></li> <li><a href="/wiki/Meprylcaine" title="Meprylcaine">Meprylcaine</a></li> <li><a href="/wiki/Metabutoxycaine" title="Metabutoxycaine">Metabutoxycaine</a></li> <li><a href="/wiki/Orthocaine" title="Orthocaine">Orthocaine</a></li> <li><a href="/wiki/Piperocaine" title="Piperocaine">Piperocaine</a></li> <li><a href="/wiki/Prilocaine" title="Prilocaine">Prilocaine</a></li> <li><a href="/wiki/Procaine" title="Procaine">Procaine</a></li> <li><a href="/wiki/Propoxycaine" title="Propoxycaine">Propoxycaine</a></li> <li><a href="/wiki/Proxymetacaine" title="Proxymetacaine">Proxymetacaine</a></li> <li><a href="/wiki/Risocaine" title="Risocaine">Risocaine</a></li> <li><a href="/wiki/Tetracaine" title="Tetracaine">Tetracaine</a></li> <li><a href="/wiki/Trimecaine" title="Trimecaine">Trimecaine</a></li></ul> <ul><li><i>Analgesics:</i> <a href="/w/index.php?title=AZD-3161&action=edit&redlink=1" class="new" title="AZD-3161 (page does not exist)">AZD-3161</a></li> <li><a href="/wiki/DSP-2230" title="DSP-2230">DSP-2230</a></li> <li><a href="/wiki/Funapide" title="Funapide">Funapide</a></li> <li><a href="/w/index.php?title=GDC-0276&action=edit&redlink=1" class="new" title="GDC-0276 (page does not exist)">GDC-0276</a></li> <li><a href="/w/index.php?title=NKTR-171&action=edit&redlink=1" class="new" title="NKTR-171 (page does not exist)">NKTR-171</a></li> <li><a href="/w/index.php?title=PF-04531083&action=edit&redlink=1" class="new" title="PF-04531083 (page does not exist)">PF-04531083</a></li> <li><a href="/wiki/PF-05089771" title="PF-05089771">PF-05089771</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Raxatrigine" class="mw-redirect" title="Raxatrigine">Raxatrigine</a></li> <li><a href="/w/index.php?title=RG7893&action=edit&redlink=1" class="new" title="RG7893 (page does not exist)">RG7893 (GDC-0287)</a></li></ul> <ul><li><i>Toxins:</i> <a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/wiki/Neosaxitoxin" title="Neosaxitoxin">Neosaxitoxin</a></li> <li><a href="/wiki/Saxitoxin" title="Saxitoxin">Saxitoxin</a></li> <li><a href="/wiki/Tetrodotoxin" title="Tetrodotoxin">Tetrodotoxin</a></li> <li><a href="/wiki/Zetekitoxin_AB" title="Zetekitoxin AB">Zetekitoxin AB</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Evenamide" title="Evenamide">Evenamide</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a> (<a href="/wiki/Mentha" title="Mentha">mint</a>)</li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aconitine" title="Aconitine">Aconitine</a></li> <li>Atracotoxins (<a href="/wiki/Omega-Atracotoxin" title="Omega-Atracotoxin">ω-Atracotoxin</a>, <a href="/wiki/Robustoxin" class="mw-redirect" title="Robustoxin">Robustoxin</a>, <a href="/wiki/Versutoxin" title="Versutoxin">Versutoxin</a>)</li> <li><a href="/wiki/Batrachotoxin" title="Batrachotoxin">Batrachotoxin</a></li> <li><a href="/wiki/Ciguatoxin" title="Ciguatoxin">Ciguatoxins</a></li> <li><a href="/wiki/Grayanotoxin" title="Grayanotoxin">Grayanotoxins</a></li> <li><a href="/wiki/Poneratoxin" title="Poneratoxin">Poneratoxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel"><abbr title="Epithelial sodium channel">ENaC</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Epithelial sodium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Benzamil" title="Benzamil">Benzamil</a></li> <li><a href="/wiki/Triamterene" title="Triamterene">Triamterene</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Solnatide&action=edit&redlink=1" class="new" title="Solnatide (page does not exist)">Solnatide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Acid-sensing_ion_channel" title="Acid-sensing ion channel"><abbr title="Acid-sensing ion channel">ASICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Acid-sensing ion channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=A-317567&action=edit&redlink=1" class="new" title="A-317567 (page does not exist)">A-317567</a></li> <li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Aspirin" title="Aspirin">Aspirin</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a></li> <li><a href="/w/index.php?title=PcTX1&action=edit&redlink=1" class="new" title="PcTX1 (page does not exist)">PcTX1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chloride_channel" title="Chloride channel">Chloride</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_chloride_channel" class="mw-redirect" title="Calcium-activated chloride channel"><abbr title="Calcium-activated chloride channel">CaCCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated chloride channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Crofelemer" title="Crofelemer">Crofelemer</a></li> <li><a href="/wiki/DIDS" title="DIDS">DIDS</a></li> <li><a href="/wiki/Ethacrynic_acid" class="mw-redirect" title="Ethacrynic acid">Ethacrynic acid</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Furosemide" title="Furosemide">Furosemide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Mefloquine" title="Mefloquine">Mefloquine</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbachol" title="Carbachol">Carbachol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator"><abbr title="Cystic fibrosis transmembrane conductance regulator">CFTR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cystic fibrosis transmembrane conductance regulator</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Lonidamine" title="Lonidamine">Lonidamine</a></li> <li><a href="/wiki/Piretanide" title="Piretanide">Piretanide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=1,7-Phenanthroline&action=edit&redlink=1" class="new" title="1,7-Phenanthroline (page does not exist)">1,7-Phenanthroline</a></li> <li><a href="/wiki/1,10-Phenanthroline" title="1,10-Phenanthroline">1,10-Phenanthroline</a></li> <li><a href="/w/index.php?title=4,7-Phenanthroline&action=edit&redlink=1" class="new" title="4,7-Phenanthroline (page does not exist)">4,7-Phenanthroline</a></li> <li><a href="/w/index.php?title=7,8-Benzoquinoline&action=edit&redlink=1" class="new" title="7,8-Benzoquinoline (page does not exist)">7,8-Benzoquinoline</a></li> <li><a href="/wiki/Ivacaftor" title="Ivacaftor">Ivacaftor</a></li> <li><a href="/wiki/Phenanthridine" title="Phenanthridine">Phenanthridine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bumetanide" title="Bumetanide">Bumetanide</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></li> <li><a href="/wiki/Mepacrine" title="Mepacrine">Mepacrine</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=Talniflumate&action=edit&redlink=1" class="new" title="Talniflumate (page does not exist)">Talniflumate</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Transient_receptor_potential_channels" class="mw-redirect" title="Transient receptor potential channels"><abbr title="Transient receptor potential channels">TRPs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Transient receptor potential channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Ligand_gated_ion_channels" class="mw-redirect" title="Ligand gated ion channels"><abbr title="Ligand gated ion channels">LGICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Ligand gated ion channels</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Pharmacomodulation" title="Template:Pharmacomodulation">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">Transient receptor potential channel modulators</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="GABAA_receptor_positive_modulators" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:GABAA_receptor_positive_modulators" title="Template:GABAA receptor positive modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:GABAA_receptor_positive_modulators" title="Template talk:GABAA receptor positive modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:GABAA_receptor_positive_modulators" title="Special:EditPage/Template:GABAA receptor positive modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="GABAA_receptor_positive_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/GABAA_receptor_positive_allosteric_modulator" title="GABAA receptor positive allosteric modulator"><abbr title="γ-Aminobutyric acid">GABA</abbr><sub>A</sub> receptor positive modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Alcohol_(chemistry)" title="Alcohol (chemistry)">Alcohols</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Brometone&action=edit&redlink=1" class="new" title="Brometone (page does not exist)">Brometone</a></li> <li><a href="/wiki/1-Butanol" title="1-Butanol">Butanol</a></li> <li><a href="/wiki/Chloralodol" title="Chloralodol">Chloralodol</a></li> <li><a href="/wiki/Chlorobutanol" title="Chlorobutanol">Chlorobutanol (cloretone)</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a> (<a href="/wiki/Alcoholic_drink" class="mw-redirect" title="Alcoholic drink">alcoholic drink</a>)</li> <li><a href="/wiki/Ethchlorvynol" title="Ethchlorvynol">Ethchlorvynol</a></li> <li><a href="/wiki/Isobutanol" title="Isobutanol">Isobutanol</a></li> <li><a href="/wiki/Isopropanol" class="mw-redirect" title="Isopropanol">Isopropanol</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Methanol" title="Methanol">Methanol</a></li> <li><a href="/wiki/Methylpentynol" title="Methylpentynol">Methylpentynol</a></li> <li><a href="/wiki/1-Pentanol" title="1-Pentanol">Pentanol</a></li> <li><a href="/wiki/Petrichloral" title="Petrichloral">Petrichloral</a></li> <li><a href="/wiki/1-Propanol" title="1-Propanol">Propanol</a></li> <li><a href="/wiki/Tert-Butanol" class="mw-redirect" title="Tert-Butanol"><i>tert</i>-Butanol (2M2P)</a></li> <li><a href="/wiki/Tert-Pentanol" class="mw-redirect" title="Tert-Pentanol"><i>tert</i>-Pentanol (2M2B)</a></li> <li><a href="/wiki/Tribromoethanol" title="Tribromoethanol">Tribromoethanol</a></li> <li><a href="/wiki/Trichloroethanol" class="mw-redirect" title="Trichloroethanol">Trichloroethanol</a></li> <li><a href="/wiki/Triclofos" title="Triclofos">Triclofos</a></li> <li><a href="/wiki/Trifluoroethanol" class="mw-redirect" title="Trifluoroethanol">Trifluoroethanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Barbiturate" title="Barbiturate">Barbiturates</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/(-)-5-(1,3-Dimethylbutyl)-5-ethylbarbituric_acid" class="mw-redirect" title="(-)-5-(1,3-Dimethylbutyl)-5-ethylbarbituric acid">(-)-DMBB</a></li> <li><a href="/wiki/Allobarbital" title="Allobarbital">Allobarbital</a></li> <li><a href="/wiki/Alphenal" title="Alphenal">Alphenal</a></li> <li><a href="/wiki/Amobarbital" title="Amobarbital">Amobarbital</a></li> <li><a href="/wiki/Aprobarbital" title="Aprobarbital">Aprobarbital</a></li> <li><a href="/wiki/Barbexaclone" title="Barbexaclone">Barbexaclone</a></li> <li><a href="/wiki/Barbital" title="Barbital">Barbital</a></li> <li><a href="/wiki/Benzobarbital" title="Benzobarbital">Benzobarbital</a></li> <li><a href="/wiki/Benzylbutylbarbiturate" title="Benzylbutylbarbiturate">Benzylbutylbarbiturate</a></li> <li><a href="/wiki/Brallobarbital" title="Brallobarbital">Brallobarbital</a></li> <li><a href="/wiki/Brophebarbital" title="Brophebarbital">Brophebarbital</a></li> <li><a href="/wiki/Butabarbital" title="Butabarbital">Butabarbital/Secbutabarbital</a></li> <li><a href="/wiki/Butalbital" title="Butalbital">Butalbital</a></li> <li><a href="/wiki/Buthalital" title="Buthalital">Buthalital</a></li> <li><a href="/wiki/Butobarbital" title="Butobarbital">Butobarbital</a></li> <li><a href="/wiki/Butallylonal" title="Butallylonal">Butallylonal</a></li> <li><a href="/wiki/Carbubarb" title="Carbubarb">Carbubarb</a></li> <li><a href="/wiki/Crotylbarbital" title="Crotylbarbital">Crotylbarbital</a></li> <li><a href="/wiki/Cyclobarbital" title="Cyclobarbital">Cyclobarbital</a></li> <li><a href="/wiki/Cyclopentobarbital" title="Cyclopentobarbital">Cyclopentobarbital</a></li> <li><a href="/wiki/Difebarbamate" title="Difebarbamate">Difebarbamate</a></li> <li><a href="/wiki/Enallylpropymal" title="Enallylpropymal">Enallylpropymal</a></li> <li><a href="/wiki/Ethallobarbital" title="Ethallobarbital">Ethallobarbital</a></li> <li><a href="/wiki/Eterobarb" title="Eterobarb">Eterobarb</a></li> <li><a href="/wiki/Febarbamate" title="Febarbamate">Febarbamate</a></li> <li><a href="/wiki/Heptabarb" title="Heptabarb">Heptabarb</a></li> <li><a href="/wiki/Heptobarbital" title="Heptobarbital">Heptobarbital</a></li> <li><a href="/wiki/Hexethal" title="Hexethal">Hexethal</a></li> <li><a href="/wiki/Hexobarbital" title="Hexobarbital">Hexobarbital</a></li> <li><a href="/wiki/Metharbital" title="Metharbital">Metharbital</a></li> <li><a href="/wiki/Methitural" title="Methitural">Methitural</a></li> <li><a href="/wiki/Methohexital" title="Methohexital">Methohexital</a></li> <li><a href="/wiki/Methylphenobarbital" title="Methylphenobarbital">Methylphenobarbital</a></li> <li><a href="/wiki/Narcobarbital" title="Narcobarbital">Narcobarbital</a></li> <li><a href="/wiki/Nealbarbital" title="Nealbarbital">Nealbarbital</a></li> <li><a href="/wiki/Pentobarbital" title="Pentobarbital">Pentobarbital</a></li> <li><a href="/wiki/Phenallymal" class="mw-redirect" title="Phenallymal">Phenallymal</a></li> <li><a href="/wiki/Phenobarbital" title="Phenobarbital">Phenobarbital</a></li> <li><a href="/wiki/Phetharbital" title="Phetharbital">Phetharbital</a></li> <li><a href="/wiki/Primidone" title="Primidone">Primidone</a></li> <li><a href="/wiki/Probarbital" title="Probarbital">Probarbital</a></li> <li><a href="/wiki/Propallylonal" title="Propallylonal">Propallylonal</a></li> <li><a href="/wiki/Propylbarbital" title="Propylbarbital">Propylbarbital</a></li> <li><a href="/wiki/Proxibarbital" title="Proxibarbital">Proxibarbital</a></li> <li><a href="/wiki/Reposal" title="Reposal">Reposal</a></li> <li><a href="/wiki/Secobarbital" title="Secobarbital">Secobarbital</a></li> <li><a href="/wiki/Sigmodal" title="Sigmodal">Sigmodal</a></li> <li><a href="/wiki/Spirobarbital" title="Spirobarbital">Spirobarbital</a></li> <li><a href="/wiki/Talbutal" title="Talbutal">Talbutal</a></li> <li><a href="/wiki/Tetrabamate" title="Tetrabamate">Tetrabamate</a></li> <li><a href="/wiki/Tetrabarbital" title="Tetrabarbital">Tetrabarbital</a></li> <li><a href="/wiki/Thialbarbital" title="Thialbarbital">Thialbarbital</a></li> <li><a href="/wiki/Thiamylal" title="Thiamylal">Thiamylal</a></li> <li><a href="/wiki/Thiobarbital" title="Thiobarbital">Thiobarbital</a></li> <li><a href="/wiki/Thiobutabarbital" title="Thiobutabarbital">Thiobutabarbital</a></li> <li><a href="/wiki/Sodium_thiopental" title="Sodium thiopental">Thiopental</a></li> <li><a href="/wiki/Thiotetrabarbital" title="Thiotetrabarbital">Thiotetrabarbital</a></li> <li><a href="/wiki/Valofane" title="Valofane">Valofane</a></li> <li><a href="/wiki/Vinbarbital" title="Vinbarbital">Vinbarbital</a></li> <li><a href="/wiki/Vinylbital" title="Vinylbital">Vinylbital</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Benzodiazepine" title="Benzodiazepine">Benzodiazepines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Oxoquazepam" title="2-Oxoquazepam">2-Oxoquazepam</a></li> <li><a href="/wiki/3-Hydroxyphenazepam" title="3-Hydroxyphenazepam">3-Hydroxyphenazepam</a></li> <li><a href="/wiki/Adinazolam" title="Adinazolam">Adinazolam</a></li> <li><a href="/wiki/Alprazolam" title="Alprazolam">Alprazolam</a></li> <li><a href="/wiki/Arfendazam" title="Arfendazam">Arfendazam</a></li> <li><a href="/wiki/Avizafone" title="Avizafone">Avizafone</a></li> <li><a href="/wiki/Bentazepam" title="Bentazepam">Bentazepam</a></li> <li><a href="/wiki/Bretazenil" title="Bretazenil">Bretazenil</a></li> <li><a href="/wiki/Bromazepam" title="Bromazepam">Bromazepam</a></li> <li><a href="/wiki/Bromazolam" title="Bromazolam">Bromazolam</a></li> <li><a href="/wiki/Brotizolam" title="Brotizolam">Brotizolam</a></li> <li><a href="/wiki/Camazepam" title="Camazepam">Camazepam</a></li> <li><a href="/wiki/Carburazepam" title="Carburazepam">Carburazepam</a></li> <li><a href="/wiki/Chlordiazepoxide" title="Chlordiazepoxide">Chlordiazepoxide</a></li> <li><a href="/wiki/Ciclotizolam" title="Ciclotizolam">Ciclotizolam</a></li> <li><a href="/wiki/Cinazepam" title="Cinazepam">Cinazepam</a></li> <li><a href="/wiki/Cinolazepam" title="Cinolazepam">Cinolazepam</a></li> <li><a href="/wiki/Clazolam" title="Clazolam">Clazolam</a></li> <li><a href="/wiki/Climazolam" title="Climazolam">Climazolam</a></li> <li><a href="/wiki/Clobazam" title="Clobazam">Clobazam</a></li> <li><a href="/wiki/Clonazepam" title="Clonazepam">Clonazepam</a></li> <li><a href="/wiki/Clonazolam" title="Clonazolam">Clonazolam</a></li> <li><a href="/wiki/Cloniprazepam" title="Cloniprazepam">Cloniprazepam</a></li> <li><a href="/wiki/Clorazepate" title="Clorazepate">Clorazepate</a></li> <li><a href="/wiki/Clotiazepam" title="Clotiazepam">Clotiazepam</a></li> <li><a href="/wiki/Cloxazolam" title="Cloxazolam">Cloxazolam</a></li> <li><a href="/wiki/CP-1414S" title="CP-1414S">CP-1414S</a></li> <li><a href="/wiki/Cyprazepam" title="Cyprazepam">Cyprazepam</a></li> <li><a href="/wiki/Delorazepam" title="Delorazepam">Delorazepam</a></li> <li><a href="/wiki/Demoxepam" title="Demoxepam">Demoxepam</a></li> <li><a href="/wiki/Diazepam" title="Diazepam">Diazepam</a></li> <li><a href="/wiki/Diclazepam" title="Diclazepam">Diclazepam</a></li> <li><a href="/wiki/Dimdazenil" title="Dimdazenil">Dimdazenil</a></li> <li><a href="/wiki/Doxefazepam" title="Doxefazepam">Doxefazepam</a></li> <li><a href="/wiki/Elfazepam" title="Elfazepam">Elfazepam</a></li> <li><a href="/wiki/Estazolam" title="Estazolam">Estazolam</a></li> <li><a href="/wiki/Ethyl_carfluzepate" title="Ethyl carfluzepate">Ethyl carfluzepate</a></li> <li><a href="/wiki/Ethyl_dirazepate" title="Ethyl dirazepate">Ethyl dirazepate</a></li> <li><a href="/wiki/Ethyl_loflazepate" title="Ethyl loflazepate">Ethyl loflazepate</a></li> <li><a href="/wiki/Etizolam" title="Etizolam">Etizolam</a></li> <li><a href="/wiki/FG-8205" title="FG-8205">FG-8205</a></li> <li><a href="/wiki/Fletazepam" title="Fletazepam">Fletazepam</a></li> <li><a href="/wiki/Flubromazepam" title="Flubromazepam">Flubromazepam</a></li> <li><a href="/wiki/Flubromazolam" title="Flubromazolam">Flubromazolam</a></li> <li><a href="/wiki/Fludiazepam" title="Fludiazepam">Fludiazepam</a></li> <li><a href="/wiki/Flunitrazepam" title="Flunitrazepam">Flunitrazepam</a></li> <li><a href="/wiki/Flunitrazolam" title="Flunitrazolam">Flunitrazolam</a></li> <li><a href="/wiki/Flurazepam" title="Flurazepam">Flurazepam</a></li> <li><a href="/wiki/Flutazolam" title="Flutazolam">Flutazolam</a></li> <li><a href="/wiki/Flutemazepam" title="Flutemazepam">Flutemazepam</a></li> <li><a href="/wiki/Flutoprazepam" title="Flutoprazepam">Flutoprazepam</a></li> <li><a href="/wiki/Fosazepam" title="Fosazepam">Fosazepam</a></li> <li><a href="/wiki/Gidazepam" title="Gidazepam">Gidazepam</a></li> <li><a href="/wiki/Halazepam" title="Halazepam">Halazepam</a></li> <li><a href="/wiki/Haloxazolam" title="Haloxazolam">Haloxazolam</a></li> <li><a href="/wiki/Iclazepam" title="Iclazepam">Iclazepam</a></li> <li><a href="/wiki/Imidazenil" title="Imidazenil">Imidazenil</a></li> <li><a href="/wiki/Irazepine" title="Irazepine">Irazepine</a></li> <li><a href="/wiki/Ketazolam" title="Ketazolam">Ketazolam</a></li> <li><a href="/wiki/Lofendazam" title="Lofendazam">Lofendazam</a></li> <li><a href="/wiki/Lopirazepam" title="Lopirazepam">Lopirazepam</a></li> <li><a href="/wiki/Loprazolam" title="Loprazolam">Loprazolam</a></li> <li><a href="/wiki/Lorazepam" title="Lorazepam">Lorazepam</a></li> <li><a href="/wiki/Lormetazepam" title="Lormetazepam">Lormetazepam</a></li> <li><a href="/wiki/Meclonazepam" title="Meclonazepam">Meclonazepam</a></li> <li><a href="/wiki/Medazepam" title="Medazepam">Medazepam</a></li> <li><a href="/wiki/Menitrazepam" title="Menitrazepam">Menitrazepam</a></li> <li><a href="/wiki/Metaclazepam" title="Metaclazepam">Metaclazepam</a></li> <li><a href="/wiki/Mexazolam" title="Mexazolam">Mexazolam</a></li> <li><a href="/wiki/Midazolam" title="Midazolam">Midazolam</a></li> <li><a href="/wiki/Motrazepam" title="Motrazepam">Motrazepam</a></li> <li><a href="/wiki/N-Desalkylflurazepam" title="N-Desalkylflurazepam">N-Desalkylflurazepam</a></li> <li><a href="/wiki/Nifoxipam" title="Nifoxipam">Nifoxipam</a></li> <li><a href="/wiki/Nimetazepam" title="Nimetazepam">Nimetazepam</a></li> <li><a href="/wiki/Nitrazepam" title="Nitrazepam">Nitrazepam</a></li> <li><a href="/wiki/Nitrazepate" title="Nitrazepate">Nitrazepate</a></li> <li><a href="/wiki/Nitrazolam" title="Nitrazolam">Nitrazolam</a></li> <li><a href="/wiki/Nordazepam" title="Nordazepam">Nordazepam</a></li> <li><a href="/wiki/Nortetrazepam" title="Nortetrazepam">Nortetrazepam</a></li> <li><a href="/wiki/Oxazepam" title="Oxazepam">Oxazepam</a></li> <li><a href="/wiki/Oxazolam" title="Oxazolam">Oxazolam</a></li> <li><a href="/wiki/Phenazepam" title="Phenazepam">Phenazepam</a></li> <li><a href="/wiki/Pinazepam" title="Pinazepam">Pinazepam</a></li> <li><a href="/wiki/Pivoxazepam" title="Pivoxazepam">Pivoxazepam</a></li> <li><a href="/wiki/Prazepam" title="Prazepam">Prazepam</a></li> <li><a href="/wiki/Premazepam" title="Premazepam">Premazepam</a></li> <li><a href="/wiki/Proflazepam" title="Proflazepam">Proflazepam</a></li> <li><a href="/wiki/Pyrazolam" title="Pyrazolam">Pyrazolam</a></li> <li><a href="/wiki/QH-II-66" title="QH-II-66">QH-II-66</a></li> <li><a href="/wiki/Quazepam" title="Quazepam">Quazepam</a></li> <li><a href="/wiki/Reclazepam" title="Reclazepam">Reclazepam</a></li> <li><a href="/wiki/Remimazolam" title="Remimazolam">Remimazolam</a></li> <li><a href="/wiki/Rilmazafone" title="Rilmazafone">Rilmazafone</a></li> <li><a href="/wiki/Ripazepam" title="Ripazepam">Ripazepam</a></li> <li><a href="/wiki/Ro48-6791" title="Ro48-6791">Ro48-6791</a></li> <li><a href="/wiki/Ro48-8684" title="Ro48-8684">Ro48-8684</a></li> <li><a href="/wiki/SH-053-R-CH3-2%E2%80%B2F" title="SH-053-R-CH3-2′F">SH-053-R-CH3-2′F</a></li> <li><a href="/wiki/Sulazepam" title="Sulazepam">Sulazepam</a></li> <li><a href="/wiki/Temazepam" title="Temazepam">Temazepam</a></li> <li><a href="/wiki/Tetrazepam" title="Tetrazepam">Tetrazepam</a></li> <li><a href="/wiki/Tolufazepam" class="mw-redirect" title="Tolufazepam">Tolufazepam</a></li> <li><a href="/wiki/Triazolam" title="Triazolam">Triazolam</a></li> <li><a href="/wiki/Triflubazam" title="Triflubazam">Triflubazam</a></li> <li><a href="/wiki/Triflunordazepam" title="Triflunordazepam">Triflunordazepam (Ro5-2904)</a></li> <li><a href="/wiki/Tuclazepam" title="Tuclazepam">Tuclazepam</a></li> <li><a href="/wiki/Uldazepam" title="Uldazepam">Uldazepam</a></li> <li><a href="/wiki/Zapizolam" title="Zapizolam">Zapizolam</a></li> <li><a href="/wiki/Zolazepam" title="Zolazepam">Zolazepam</a></li> <li><a href="/wiki/Zomebazam" title="Zomebazam">Zomebazam</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Carbamate" title="Carbamate">Carbamates</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carisbamate" title="Carisbamate">Carisbamate</a></li> <li><a href="/wiki/Carisoprodol" title="Carisoprodol">Carisoprodol</a></li> <li><a href="/wiki/Clocental" title="Clocental">Clocental</a></li> <li><a href="/wiki/Cyclarbamate" title="Cyclarbamate">Cyclarbamate</a></li> <li><a href="/wiki/Difebarbamate" title="Difebarbamate">Difebarbamate</a></li> <li><a href="/wiki/Emylcamate" title="Emylcamate">Emylcamate</a></li> <li><a href="/wiki/Ethinamate" title="Ethinamate">Ethinamate</a></li> <li><a href="/wiki/Febarbamate" title="Febarbamate">Febarbamate</a></li> <li><a href="/wiki/Felbamate" title="Felbamate">Felbamate</a></li> <li><a href="/wiki/Hexapropymate" title="Hexapropymate">Hexapropymate</a></li> <li><a href="/wiki/Hydroxyphenamate" title="Hydroxyphenamate">Hydroxyphenamate</a></li> <li><a href="/wiki/Lorbamate" title="Lorbamate">Lorbamate</a></li> <li><a href="/wiki/Mebutamate" title="Mebutamate">Mebutamate</a></li> <li><a href="/wiki/Meprobamate" title="Meprobamate">Meprobamate</a></li> <li><a href="/wiki/Nisobamate" title="Nisobamate">Nisobamate</a></li> <li><a href="/wiki/Pentabamate" title="Pentabamate">Pentabamate</a></li> <li><a href="/wiki/Phenprobamate" title="Phenprobamate">Phenprobamate</a></li> <li><a href="/wiki/Procymate" title="Procymate">Procymate</a></li> <li><a href="/wiki/Styramate" title="Styramate">Styramate</a></li> <li><a href="/wiki/Tetrabamate" title="Tetrabamate">Tetrabamate</a></li> <li><a href="/wiki/Tybamate" title="Tybamate">Tybamate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Flavonoid" title="Flavonoid">Flavonoids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/6-Methylapigenin" title="6-Methylapigenin">6-Methylapigenin</a></li> <li><a href="/wiki/Ampelopsin" title="Ampelopsin">Ampelopsin (dihydromyricetin)</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/Baicalein" title="Baicalein">Baicalein</a></li> <li><a href="/wiki/Baicalin" title="Baicalin">Baicalin</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epigallocatechin" class="mw-redirect" title="Epigallocatechin">EGC</a></li> <li><a href="/wiki/Epigallocatechin_gallate" title="Epigallocatechin gallate">EGCG</a></li> <li><a href="/wiki/Hispidulin" title="Hispidulin">Hispidulin</a></li> <li><a href="/w/index.php?title=Linarin&action=edit&redlink=1" class="new" title="Linarin (page does not exist)">Linarin</a></li> <li><a href="/wiki/Luteolin" title="Luteolin">Luteolin</a></li> <li><a href="/w/index.php?title=Trans-6,4%E2%80%B2-dimethoxyretrochalcone&action=edit&redlink=1" class="new" title="Trans-6,4′-dimethoxyretrochalcone (page does not exist)">Rc-OMe</a></li> <li><a href="/wiki/Scutellaria" title="Scutellaria">Skullcap</a> constituents (e.g., <a href="/wiki/Baicalin" title="Baicalin">baicalin</a>)</li> <li><a href="/wiki/Wogonin" title="Wogonin">Wogonin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Imidazole" title="Imidazole">Imidazoles</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Etomidate" title="Etomidate">Etomidate</a></li> <li><a href="/wiki/Metomidate" title="Metomidate">Metomidate</a></li> <li><a href="/wiki/Propoxate" title="Propoxate">Propoxate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a class="mw-selflink selflink">Kava</a> constituents</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=10-Methoxyyangonin&action=edit&redlink=1" class="new" title="10-Methoxyyangonin (page does not exist)">10-Methoxyyangonin</a></li> <li><a href="/w/index.php?title=11-Methoxyyangonin&action=edit&redlink=1" class="new" title="11-Methoxyyangonin (page does not exist)">11-Methoxyyangonin</a></li> <li><a href="/w/index.php?title=11-Hydroxyyangonin&action=edit&redlink=1" class="new" title="11-Hydroxyyangonin (page does not exist)">11-Hydroxyyangonin</a></li> <li><a href="/wiki/Desmethoxyyangonin" title="Desmethoxyyangonin">Desmethoxyyangonin</a></li> <li><a href="/w/index.php?title=11-Methoxy-12-hydroxydehydrokavain&action=edit&redlink=1" class="new" title="11-Methoxy-12-hydroxydehydrokavain (page does not exist)">11-Methoxy-12-hydroxydehydrokavain</a></li> <li><a href="/w/index.php?title=7,8-Dihydroyangonin&action=edit&redlink=1" class="new" title="7,8-Dihydroyangonin (page does not exist)">7,8-Dihydroyangonin</a></li> <li><a href="/wiki/Kavain" title="Kavain">Kavain</a></li> <li><a href="/w/index.php?title=5-Hydroxykavain&action=edit&redlink=1" class="new" title="5-Hydroxykavain (page does not exist)">5-Hydroxykavain</a></li> <li><a href="/w/index.php?title=5,6-Dihydroyangonin&action=edit&redlink=1" class="new" title="5,6-Dihydroyangonin (page does not exist)">5,6-Dihydroyangonin</a></li> <li><a href="/w/index.php?title=7,8-Dihydrokavain&action=edit&redlink=1" class="new" title="7,8-Dihydrokavain (page does not exist)">7,8-Dihydrokavain</a></li> <li><a href="/w/index.php?title=5,6,7,8-Tetrahydroyangonin&action=edit&redlink=1" class="new" title="5,6,7,8-Tetrahydroyangonin (page does not exist)">5,6,7,8-Tetrahydroyangonin</a></li> <li><a href="/w/index.php?title=5,6-Dehydromethysticin&action=edit&redlink=1" class="new" title="5,6-Dehydromethysticin (page does not exist)">5,6-Dehydromethysticin</a></li> <li><a href="/wiki/Methysticin" title="Methysticin">Methysticin</a></li> <li><a href="/w/index.php?title=7,8-Dihydromethysticin&action=edit&redlink=1" class="new" title="7,8-Dihydromethysticin (page does not exist)">7,8-Dihydromethysticin</a></li> <li><a href="/wiki/Yangonin" title="Yangonin">Yangonin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Monoureide" class="mw-redirect" title="Monoureide">Monoureides</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acecarbromal" title="Acecarbromal">Acecarbromal</a></li> <li><a href="/wiki/Apronal" title="Apronal">Apronal (apronalide)</a></li> <li><a href="/wiki/Bromisoval" title="Bromisoval">Bromisoval</a></li> <li><a href="/wiki/Carbromal" title="Carbromal">Carbromal</a></li> <li><a href="/w/index.php?title=Capuride&action=edit&redlink=1" class="new" title="Capuride (page does not exist)">Capuride</a></li> <li><a href="/w/index.php?title=Ectylurea&action=edit&redlink=1" class="new" title="Ectylurea (page does not exist)">Ectylurea</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Neuroactive_steroid" class="mw-redirect" title="Neuroactive steroid">Neuroactive steroids</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acebrochol" title="Acebrochol">Acebrochol</a></li> <li><a href="/wiki/Allopregnanolone" title="Allopregnanolone">Allopregnanolone (brexanolone)</a></li> <li><a href="/wiki/Alfadolone" title="Alfadolone">Alfadolone</a></li> <li><a href="/wiki/Alfaxalone" title="Alfaxalone">Alfaxalone</a></li> <li><a href="/wiki/3%CE%B1-Androstanediol" title="3α-Androstanediol">3α-Androstanediol</a></li> <li><a href="/wiki/Androstenol" title="Androstenol">Androstenol</a></li> <li><a href="/wiki/Androsterone" title="Androsterone">Androsterone</a></li> <li>Certain <a href="/wiki/Anabolic-androgenic_steroid" class="mw-redirect" title="Anabolic-androgenic steroid">anabolic-androgenic steroids</a></li> <li><a href="/wiki/Cholesterol" title="Cholesterol">Cholesterol</a></li> <li><a href="/wiki/Dihydrodeoxycorticosterone" title="Dihydrodeoxycorticosterone">DHDOC</a></li> <li><a href="/wiki/3%CE%B1-Dihydroprogesterone" title="3α-Dihydroprogesterone">3α-DHP</a></li> <li><a href="/wiki/5%CE%B1-Dihydroprogesterone" title="5α-Dihydroprogesterone">5α-DHP</a></li> <li><a href="/wiki/5%CE%B2-Dihydroprogesterone" title="5β-Dihydroprogesterone">5β-DHP</a></li> <li><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">DHT</a></li> <li><a href="/wiki/Etiocholanolone" title="Etiocholanolone">Etiocholanolone</a></li> <li><a href="/wiki/Ganaxolone" title="Ganaxolone">Ganaxolone</a></li> <li><a href="/wiki/Hydroxydione" title="Hydroxydione">Hydroxydione</a></li> <li><a href="/wiki/Minaxolone" title="Minaxolone">Minaxolone</a></li> <li><a href="/wiki/ORG-20599" title="ORG-20599">ORG-20599</a></li> <li><a href="/wiki/ORG-21465" title="ORG-21465">ORG-21465</a></li> <li><a href="/wiki/P1-185" title="P1-185">P1-185</a></li> <li><a href="/wiki/Posovolone" title="Posovolone">Posovolone</a></li> <li><a href="/wiki/Pregnanolone" title="Pregnanolone">Pregnanolone (eltanolone)</a></li> <li><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></li> <li><a href="/wiki/Renanolone" title="Renanolone">Renanolone</a></li> <li><a href="/w/index.php?title=SAGE-105&action=edit&redlink=1" class="new" title="SAGE-105 (page does not exist)">SAGE-105</a></li> <li><a href="/wiki/SAGE-324" title="SAGE-324">SAGE-324</a></li> <li><a href="/w/index.php?title=SAGE-516&action=edit&redlink=1" class="new" title="SAGE-516 (page does not exist)">SAGE-516</a></li> <li><a href="/w/index.php?title=SAGE-689&action=edit&redlink=1" class="new" title="SAGE-689 (page does not exist)">SAGE-689</a></li> <li><a href="/w/index.php?title=SAGE-872&action=edit&redlink=1" class="new" title="SAGE-872 (page does not exist)">SAGE-872</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li> <li><a href="/wiki/Tetrahydrodeoxycorticosterone" title="Tetrahydrodeoxycorticosterone">THDOC</a></li> <li><a href="/wiki/Zuranolone" title="Zuranolone">Zuranolone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Nonbenzodiazepine" title="Nonbenzodiazepine">Nonbenzodiazepines</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Cyclopyrrolone" class="mw-redirect" title="Cyclopyrrolone">Cyclopyrrolones</a></i>: <a href="/wiki/Eszopiclone" title="Eszopiclone">Eszopiclone</a></li> <li><a href="/wiki/Pagoclone" title="Pagoclone">Pagoclone</a></li> <li><a href="/wiki/Pazinaclone" title="Pazinaclone">Pazinaclone</a></li> <li><a href="/wiki/Suproclone" title="Suproclone">Suproclone</a></li> <li><a href="/wiki/Suriclone" title="Suriclone">Suriclone</a></li> <li><a href="/wiki/Zopiclone" title="Zopiclone">Zopiclone</a></li></ul> <ul><li><i><a href="/wiki/Imidazopyridine" title="Imidazopyridine">Imidazopyridines</a></i>: <a href="/wiki/Alpidem" title="Alpidem">Alpidem</a></li> <li><a href="/wiki/DS-1_(drug)" title="DS-1 (drug)">DS-1</a></li> <li><a href="/wiki/Necopidem" title="Necopidem">Necopidem</a></li> <li><a href="/wiki/Saripidem" title="Saripidem">Saripidem</a></li> <li><a href="/wiki/Zolpidem" title="Zolpidem">Zolpidem</a></li></ul> <ul><li><i><a href="/wiki/Pyrazolopyrimidine" title="Pyrazolopyrimidine">Pyrazolopyrimidines</a></i>: <a href="/wiki/Divaplon" title="Divaplon">Divaplon</a></li> <li><a href="/wiki/Fasiplon" title="Fasiplon">Fasiplon</a></li> <li><a href="/wiki/Indiplon" title="Indiplon">Indiplon</a></li> <li><a href="/wiki/Lorediplon" title="Lorediplon">Lorediplon</a></li> <li><a href="/wiki/Ocinaplon" title="Ocinaplon">Ocinaplon</a></li> <li><a href="/wiki/Panadiplon" title="Panadiplon">Panadiplon</a></li> <li><a href="/wiki/Taniplon" title="Taniplon">Taniplon</a></li> <li><a href="/wiki/Zaleplon" title="Zaleplon">Zaleplon</a></li></ul> <ul><li><i>Others</i>: <a href="/wiki/Adipiplon" title="Adipiplon">Adipiplon</a></li> <li><a href="/wiki/CGS-8216" title="CGS-8216">CGS-8216</a></li> <li><a href="/wiki/CGS-9896" title="CGS-9896">CGS-9896</a></li> <li><a href="/wiki/CGS-13767" title="CGS-13767">CGS-13767</a></li> <li><a href="/wiki/CGS-20625" title="CGS-20625">CGS-20625</a></li> <li><a href="/wiki/CL-218,872" title="CL-218,872">CL-218,872</a></li> <li><a href="/wiki/CP-615,003" title="CP-615,003">CP-615,003</a></li> <li><a href="/w/index.php?title=CTP-354&action=edit&redlink=1" class="new" title="CTP-354 (page does not exist)">CTP-354</a></li> <li><a href="/wiki/ELB-139" title="ELB-139">ELB-139</a></li> <li><a href="/wiki/GBLD-345" title="GBLD-345">GBLD-345</a></li> <li><a href="/wiki/Imepitoin" title="Imepitoin">Imepitoin</a></li> <li><a href="/wiki/JM-1232" title="JM-1232">JM-1232</a></li> <li><a href="/wiki/L-838,417" title="L-838,417">L-838,417</a></li> <li><a href="/wiki/Lirequinil" title="Lirequinil">Lirequinil (Ro41-3696)</a></li> <li><a href="/wiki/NS-2664" title="NS-2664">NS-2664</a></li> <li><a href="/wiki/NS-2710" title="NS-2710">NS-2710</a></li> <li><a href="/wiki/NS-11394" title="NS-11394">NS-11394</a></li> <li><a href="/wiki/Pipequaline" title="Pipequaline">Pipequaline</a></li> <li><a href="/wiki/ROD-188" title="ROD-188">ROD-188</a></li> <li><a href="/wiki/RWJ-51204" title="RWJ-51204">RWJ-51204</a></li> <li><a href="/wiki/SB-205,384" class="mw-redirect" title="SB-205,384">SB-205,384</a></li> <li><a href="/wiki/SX-3228" title="SX-3228">SX-3228</a></li> <li><a href="/w/index.php?title=TGSC01AA&action=edit&redlink=1" class="new" title="TGSC01AA (page does not exist)">TGSC01AA</a></li> <li><a href="/wiki/TP-003" title="TP-003">TP-003</a></li> <li><a href="/wiki/TPA-023" title="TPA-023">TPA-023</a></li> <li><a href="/wiki/TP-13" title="TP-13">TP-13</a></li> <li><a href="/wiki/U-89843A" title="U-89843A">U-89843A</a></li> <li><a href="/wiki/U-90042" title="U-90042">U-90042</a></li> <li><a href="/wiki/Viqualine" title="Viqualine">Viqualine</a></li> <li><a href="/wiki/Y-23684" title="Y-23684">Y-23684</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Phenol" title="Phenol">Phenols</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fospropofol" title="Fospropofol">Fospropofol</a></li> <li><a href="/wiki/Propofol" title="Propofol">Propofol</a></li> <li><a href="/wiki/Thymol" title="Thymol">Thymol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Piperidinedione" class="mw-redirect" title="Piperidinedione">Piperidinediones</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glutethimide" title="Glutethimide">Glutethimide</a></li> <li><a href="/wiki/Methyprylon" title="Methyprylon">Methyprylon</a></li> <li><a href="/wiki/Piperidione" title="Piperidione">Piperidione</a></li> <li><a href="/wiki/Pyrithyldione" title="Pyrithyldione">Pyrithyldione</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Pyrazolopyridine" class="mw-redirect" title="Pyrazolopyridine">Pyrazolopyridines</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cartazolate" title="Cartazolate">Cartazolate</a></li> <li><a href="/wiki/Etazolate" title="Etazolate">Etazolate</a></li> <li><a href="/wiki/ICI-190,622" title="ICI-190,622">ICI-190,622</a></li> <li><a href="/wiki/Tracazolate" title="Tracazolate">Tracazolate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Quinazolinone" title="Quinazolinone">Quinazolinones</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Afloqualone" title="Afloqualone">Afloqualone</a></li> <li><a href="/wiki/Cloroqualone" title="Cloroqualone">Cloroqualone</a></li> <li><a href="/wiki/Diproqualone" title="Diproqualone">Diproqualone</a></li> <li><a href="/wiki/Etaqualone" title="Etaqualone">Etaqualone</a></li> <li><a href="/wiki/Mebroqualone" title="Mebroqualone">Mebroqualone</a></li> <li><a href="/wiki/Mecloqualone" title="Mecloqualone">Mecloqualone</a></li> <li><a href="/wiki/Methaqualone" title="Methaqualone">Methaqualone</a></li> <li><a href="/wiki/Methylmethaqualone" title="Methylmethaqualone">Methylmethaqualone</a></li> <li><a href="/wiki/Nitromethaqualone" title="Nitromethaqualone">Nitromethaqualone</a></li> <li><a href="/wiki/SL-164" title="SL-164">SL-164</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;"><a href="/wiki/Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">Volatiles</a>/<a href="/wiki/Inhalational_anaesthetic" class="mw-redirect" title="Inhalational anaesthetic">gases</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetone" title="Acetone">Acetone</a></li> <li><a href="/wiki/Acetophenone" title="Acetophenone">Acetophenone</a></li> <li><a href="/wiki/Acetylglycinamide_chloral_hydrate" title="Acetylglycinamide chloral hydrate">Acetylglycinamide chloral hydrate</a></li> <li><a href="/wiki/Aliflurane" title="Aliflurane">Aliflurane</a></li> <li><a href="/wiki/Benzene" title="Benzene">Benzene</a></li> <li><a href="/wiki/Butane" title="Butane">Butane</a></li> <li><a href="/wiki/Butylene" class="mw-redirect" title="Butylene">Butylene</a></li> <li><a href="/wiki/Centalun" title="Centalun">Centalun</a></li> <li><a href="/wiki/Chloral" title="Chloral">Chloral</a></li> <li><a href="/wiki/Chloral_betaine" title="Chloral betaine">Chloral betaine</a></li> <li><a href="/wiki/Chloral_hydrate" title="Chloral hydrate">Chloral hydrate</a></li> <li><a href="/wiki/Chloroform" title="Chloroform">Chloroform</a></li> <li><a href="/wiki/Cryofluorane" class="mw-redirect" title="Cryofluorane">Cryofluorane</a></li> <li><a href="/wiki/Desflurane" title="Desflurane">Desflurane</a></li> <li><a href="/wiki/Dichloralphenazone" title="Dichloralphenazone">Dichloralphenazone</a></li> <li><a href="/wiki/Dichloromethane" title="Dichloromethane">Dichloromethane</a></li> <li><a href="/wiki/Diethyl_ether" title="Diethyl ether">Diethyl ether</a></li> <li><a href="/wiki/Enflurane" title="Enflurane">Enflurane</a></li> <li><a href="/wiki/Chloroethane" title="Chloroethane">Ethyl chloride</a></li> <li><a href="/wiki/Ethylene" title="Ethylene">Ethylene</a></li> <li><a href="/wiki/Fluroxene" title="Fluroxene">Fluroxene</a></li> <li><a href="/wiki/Gasoline" title="Gasoline">Gasoline</a></li> <li><a href="/wiki/Halopropane" title="Halopropane">Halopropane</a></li> <li><a href="/wiki/Halothane" title="Halothane">Halothane</a></li> <li><a href="/wiki/Isoflurane" title="Isoflurane">Isoflurane</a></li> <li><a href="/wiki/Kerosene" title="Kerosene">Kerosine</a></li> <li><a href="/wiki/Methoxyflurane" title="Methoxyflurane">Methoxyflurane</a></li> <li><a href="/wiki/Methoxypropane" title="Methoxypropane">Methoxypropane</a></li> <li><a href="/wiki/Nitric_oxide" title="Nitric oxide">Nitric oxide</a></li> <li><a href="/wiki/Nitrogen" title="Nitrogen">Nitrogen</a></li> <li><a href="/wiki/Nitrous_oxide" title="Nitrous oxide">Nitrous oxide</a></li> <li><a href="/wiki/Norflurane" class="mw-redirect" title="Norflurane">Norflurane</a></li> <li><a href="/wiki/Paraldehyde" title="Paraldehyde">Paraldehyde</a></li> <li><a href="/wiki/Propane" title="Propane">Propane</a></li> <li><a href="/wiki/Propene" class="mw-redirect" title="Propene">Propylene</a></li> <li><a href="/wiki/Roflurane" title="Roflurane">Roflurane</a></li> <li><a href="/wiki/Sevoflurane" title="Sevoflurane">Sevoflurane</a></li> <li><a href="/wiki/Synthane" title="Synthane">Synthane</a></li> <li><a href="/wiki/Teflurane" title="Teflurane">Teflurane</a></li> <li><a href="/wiki/Toluene" title="Toluene">Toluene</a></li> <li><a href="/wiki/1,1,1-Trichloroethane" title="1,1,1-Trichloroethane">Trichloroethane (methyl chloroform)</a></li> <li><a href="/wiki/Trichloroethylene" title="Trichloroethylene">Trichloroethylene</a></li> <li><a href="/wiki/Divinyl_ether" title="Divinyl ether">Vinyl ether</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center;">Others/unsorted</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-Hydroxybutanal" title="3-Hydroxybutanal">3-Hydroxybutanal</a></li> <li><a href="/w/index.php?title=%CE%91-Ethyl-%CE%B1-methylthiobutyrolactone&action=edit&redlink=1" class="new" title="Α-Ethyl-α-methylthiobutyrolactone (page does not exist)">α-EMTBL</a></li> <li><a href="/w/index.php?title=AA-29504&action=edit&redlink=1" class="new" title="AA-29504 (page does not exist)">AA-29504</a></li> <li><a href="/wiki/Alogabat" title="Alogabat">Alogabat</a></li> <li><a href="/wiki/Avermectin" title="Avermectin">Avermectins</a> (e.g., <a href="/wiki/Ivermectin" title="Ivermectin">ivermectin</a>)</li> <li><a href="/wiki/Bromide" title="Bromide">Bromide</a> compounds (e.g., <a href="/wiki/Lithium_bromide" title="Lithium bromide">lithium bromide</a>, <a href="/wiki/Potassium_bromide" title="Potassium bromide">potassium bromide</a>, <a href="/wiki/Sodium_bromide" title="Sodium bromide">sodium bromide</a>)</li> <li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Chloralose" title="Chloralose">Chloralose</a></li> <li><a href="/wiki/Chlormezanone" title="Chlormezanone">Chlormezanone</a></li> <li><a href="/wiki/Clomethiazole" title="Clomethiazole">Clomethiazole</a></li> <li><a href="/wiki/Darigabat" title="Darigabat">Darigabat</a></li> <li><a href="/wiki/3,3-Diethyl-2-pyrrolidinone" title="3,3-Diethyl-2-pyrrolidinone">DEABL</a></li> <li><a href="/wiki/Deuterated_etifoxine" title="Deuterated etifoxine">Deuterated etifoxine</a></li> <li><a href="/wiki/Dihydroergoline" class="mw-redirect" title="Dihydroergoline">Dihydroergolines</a> (e.g., <a href="/wiki/Dihydroergocryptine" title="Dihydroergocryptine">dihydroergocryptine</a>, <a href="/w/index.php?title=Dihydroergosine&action=edit&redlink=1" class="new" title="Dihydroergosine (page does not exist)">dihydroergosine</a>, <a href="/wiki/Dihydroergotamine" title="Dihydroergotamine">dihydroergotamine</a>, <a href="/wiki/Ergoloid" title="Ergoloid">ergoloid (dihydroergotoxine)</a>)</li> <li><a href="/w/index.php?title=4-Chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide&action=edit&redlink=1" class="new" title="4-Chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide (page does not exist)">DS2</a></li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Etazepine" title="Etazepine">Etazepine</a></li> <li><a href="/wiki/Etifoxine" title="Etifoxine">Etifoxine</a></li> <li><a href="/wiki/Fenamate" class="mw-redirect" title="Fenamate">Fenamates</a> (e.g., <a href="/wiki/Flufenamic_acid" title="Flufenamic acid">flufenamic acid</a>, <a href="/wiki/Mefenamic_acid" title="Mefenamic acid">mefenamic acid</a>, <a href="/wiki/Niflumic_acid" title="Niflumic acid">niflumic acid</a>, <a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">tolfenamic acid</a>)</li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a></li> <li><a href="/wiki/Hopantenic_acid" title="Hopantenic acid">Hopantenic acid</a></li> <li><a href="/wiki/KRM-II-81" title="KRM-II-81">KRM-II-81</a></li> <li><a href="/wiki/Lanthanum" title="Lanthanum">Lanthanum</a></li> <li><a href="/wiki/Lavender_oil" title="Lavender oil">Lavender oil</a></li> <li><a href="/wiki/Lignan" title="Lignan">Lignans</a> (e.g., <a href="/wiki/4-O-methylhonokiol" class="mw-redirect" title="4-O-methylhonokiol">4-O-methylhonokiol</a>, <a href="/wiki/Honokiol" title="Honokiol">honokiol</a>, <a href="/wiki/Magnolol" title="Magnolol">magnolol</a>, <a href="/wiki/Obovatol" title="Obovatol">obovatol</a>)</li> <li><a href="/wiki/Loreclezole" title="Loreclezole">Loreclezole</a></li> <li><a href="/wiki/Menthyl_isovalerate" title="Menthyl isovalerate">Menthyl isovalerate (validolum)</a></li> <li><a href="/wiki/Monastrol" title="Monastrol">Monastrol</a></li> <li><a href="/wiki/Niacin" title="Niacin">Niacin</a></li> <li><a href="/wiki/Niacinamide" class="mw-redirect" title="Niacinamide">Niacinamide</a></li> <li><a href="/wiki/Org_25435" class="mw-redirect" title="Org 25435">Org 25,435</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/Propanidid" title="Propanidid">Propanidid</a></li> <li><a href="/wiki/Retigabine" title="Retigabine">Retigabine (ezogabine)</a></li> <li><a href="/wiki/Safranal" title="Safranal">Safranal</a></li> <li><a href="/wiki/Seproxetine" title="Seproxetine">Seproxetine</a></li> <li><a href="/wiki/Stiripentol" title="Stiripentol">Stiripentol</a></li> <li><a href="/w/index.php?title=Sulfonylalkane&action=edit&redlink=1" class="new" title="Sulfonylalkane (page does not exist)">Sulfonylalkanes</a> (e.g., <a href="/wiki/Sulfonmethane" title="Sulfonmethane">sulfonmethane (sulfonal)</a>, <a href="/wiki/Tetronal" title="Tetronal">tetronal</a>, <a href="/wiki/Trional" title="Trional">trional</a>)</li> <li><a href="/wiki/Terpenoid" title="Terpenoid">Terpenoids</a> (e.g., <a href="/wiki/Borneol" title="Borneol">borneol</a>)</li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/wiki/Valerian_(herb)" title="Valerian (herb)">Valerian</a> constituents (e.g., <a href="/wiki/3-methylbutanoic_acid" class="mw-redirect" title="3-methylbutanoic acid">isovaleric acid</a>, <a href="/wiki/Isovaleramide" title="Isovaleramide">isovaleramide</a>, <a href="/wiki/Valerenic_acid" title="Valerenic acid">valerenic acid</a>, <a href="/w/index.php?title=Valerenol&action=edit&redlink=1" class="new" title="Valerenol (page does not exist)">valerenol</a>)</li></ul> <ul><li><i>Unsorted benzodiazepine site positive modulators:</i> <a href="/wiki/%CE%91-Pinene" title="Α-Pinene">α-Pinene</a></li> <li><a href="/wiki/MRK-409_(MK-0343)" class="mw-redirect" title="MRK-409 (MK-0343)">MRK-409 (MK-0343)</a></li> <li><a href="/w/index.php?title=TCS-1105&action=edit&redlink=1" class="new" title="TCS-1105 (page does not exist)">TCS-1105</a></li> <li><a href="/wiki/TCS-1205" title="TCS-1205">TCS-1205</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:GABA_receptor_modulators" title="Template:GABA receptor modulators">GABA receptor modulators</a> • <a href="/wiki/Template:GABA_metabolism_and_transport_modulators" title="Template:GABA metabolism and transport modulators">GABA metabolism/transport modulators</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Opioid_receptor_modulators" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Opioid_receptor_modulators" title="Template:Opioid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Opioid_receptor_modulators" title="Template talk:Opioid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Opioid_receptor_modulators" title="Special:EditPage/Template:Opioid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Opioid_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-opioid</a><br />(MOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Agonists(abridged;_full_list)" scope="row" class="navbox-group" style="width:1%">Agonists<br />(abridged;<br /> <a href="/wiki/List_of_opioids" title="List of opioids">full list</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-HO-PCP" title="3-HO-PCP">3-HO-PCP</a></li> <li><a href="/w/index.php?title=7-Acetoxymitragynine&action=edit&redlink=1" class="new" title="7-Acetoxymitragynine (page does not exist)">7-Acetoxymitragynine</a></li> <li><a href="/wiki/7-Hydroxymitragynine" title="7-Hydroxymitragynine">7-Hydroxymitragynine</a></li> <li><a href="/w/index.php?title=%CE%A8-Akuammigine&action=edit&redlink=1" class="new" title="Ψ-Akuammigine (page does not exist)">ψ-Akuammigine</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">α-Chlornaltrexamine</a></li> <li><a href="/w/index.php?title=Alpha-Narcotine&action=edit&redlink=1" class="new" title="Alpha-Narcotine (page does not exist)">α-Narcotine</a></li> <li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Acetylfentanyl" title="Acetylfentanyl">Acetylfentanyl</a></li> <li><a href="/wiki/Acrylfentanyl" title="Acrylfentanyl">Acrylfentanyl</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/AH-7921" title="AH-7921">AH-7921</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/w/index.php?title=Akuammidine&action=edit&redlink=1" class="new" title="Akuammidine (page does not exist)">Akuammidine</a></li> <li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Apparicine" title="Apparicine">Apparicine</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Benzhydrocodone" title="Benzhydrocodone">Benzhydrocodone</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Butyrfentanyl" title="Butyrfentanyl">Butyrfentanyl</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Chloroxymorphamine" title="Chloroxymorphamine">Chloroxymorphamine</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/DAMGO" title="DAMGO">DAMGO (DAGO)</a></li> <li><a href="/wiki/Dermorphin" title="Dermorphin">Dermorphin</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene (propoxyphene)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dimethylaminopivalophenone" title="Dimethylaminopivalophenone">Dimethylaminopivalophenone</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diphenoxylate" title="Diphenoxylate">Diphenoxylate</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/Endomorphin-1" title="Endomorphin-1">Endomorphin-1</a></li> <li><a href="/wiki/Endomorphin-2" title="Endomorphin-2">Endomorphin-2</a></li> <li><a href="/wiki/Eseroline" title="Eseroline">Eseroline</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Frakefamide" title="Frakefamide">Frakefamide</a></li> <li><a href="/wiki/Furanylfentanyl" title="Furanylfentanyl">Furanylfentanyl</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/Hodgkinsine" title="Hodgkinsine">Hodgkinsine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/IBNtxA" title="IBNtxA">IBNtxA</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levacetylmethadol" title="Levacetylmethadol">Levacetylmethadol</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Loxicodegol" class="mw-redirect" title="Loxicodegol">Loxicodegol</a></li> <li><a href="/wiki/LS-115509" title="LS-115509">LS-115509</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphiceptin" title="Morphiceptin">Morphiceptin</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalmexone" title="Nalmexone">Nalmexone</a></li> <li><a href="/wiki/Naltalimide" title="Naltalimide">Naltalimide</a></li> <li><a href="/w/index.php?title=Neopine&action=edit&redlink=1" class="new" title="Neopine (page does not exist)">Neopine</a></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Nufenoxole" title="Nufenoxole">Nufenoxole</a></li> <li><a href="/wiki/Octreotide" title="Octreotide">Octreotide</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Oxycodegol" title="Oxycodegol">Oxycodegol</a></li> <li><a href="/wiki/Oxymorphone-3-methoxynaltrexonazine" title="Oxymorphone-3-methoxynaltrexonazine">OM-3-MNZ</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphazone" title="Oxymorphazone">Oxymorphazone</a></li> <li><a href="/w/index.php?title=Oxymorphonazine&action=edit&redlink=1" class="new" title="Oxymorphonazine (page does not exist)">Oxymorphonazine</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/w/index.php?title=Oxymorphone_phenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone phenylhydrazone (page does not exist)">Oxymorphone phenylhydrazone</a></li> <li><a href="/w/index.php?title=Oxymorphone_p-nitrophenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone p-nitrophenylhydrazone (page does not exist)">OxyPNPH</a></li> <li><i><a href="/wiki/Papaver_somniferum" title="Papaver somniferum">Papaver somniferum</a></i> (<a href="/wiki/Opium" title="Opium">opium</a>)</li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pericine" title="Pericine">Pericine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/w/index.php?title=PL-017&action=edit&redlink=1" class="new" title="PL-017 (page does not exist)">PL-017</a></li> <li><a href="/wiki/Prodine" title="Prodine">Prodine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/PZM21" title="PZM21">PZM21</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Salsolinol" title="Salsolinol">Salsolinol</a></li> <li><a href="/wiki/SC-17599" title="SC-17599">SC-17599</a></li> <li><a href="/wiki/Sinomenine" title="Sinomenine">Sinomenine</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tetrahydropapaveroline" title="Tetrahydropapaveroline">Tetrahydropapaveroline</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tianeptine" title="Tianeptine">Tianeptine</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/wiki/Trimebutine" title="Trimebutine">Trimebutine</a></li> <li><a href="/wiki/TRIMU_5" title="TRIMU 5">TRIMU 5</a></li> <li><a href="/wiki/TRV734" title="TRV734">TRV734</a></li> <li><a href="/w/index.php?title=Tubotaiwine&action=edit&redlink=1" class="new" title="Tubotaiwine (page does not exist)">Tubotaiwine</a></li> <li><a href="/wiki/U-47700" title="U-47700">U-47700</a></li> <li><a href="/wiki/Valorphin" title="Valorphin">Valorphin</a></li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Picenadol" title="Picenadol">(3S,4S)-Picenadol</a></li> <li><a href="/wiki/Viminol" title="Viminol">2-(S)-N,N-(R)-Viminol</a></li> <li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/4-Caffeoyl-1,5-quinide" title="4-Caffeoyl-1,5-quinide">4-Caffeoyl-1,5-quinide</a></li> <li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/Alpha-Gliadin" class="mw-redirect" title="Alpha-Gliadin">α-Gliadin</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Akuammine" title="Akuammine">Akuammine</a></li> <li><a href="/wiki/Alvimopan" title="Alvimopan">Alvimopan</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li>CTAP</li> <li><a href="/w/index.php?title=CTOP&action=edit&redlink=1" class="new" title="CTOP (page does not exist)">CTOP</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Cyprodime" title="Cyprodime">Cyprodime</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/w/index.php?title=Ginsenoside_R&action=edit&redlink=1" class="new" title="Ginsenoside R (page does not exist)">Ginsenoside R</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Lobeline" title="Lobeline">Lobeline</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methocinnamox" title="Methocinnamox">Methocinnamox</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylsamidorphan_chloride&action=edit&redlink=1" class="new" title="Methylsamidorphan chloride (page does not exist)">Methylsamidorphan chloride</a></li> <li><a href="/wiki/Naldemedine" title="Naldemedine">Naldemedine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Nalorphine_dinicotinate" title="Nalorphine dinicotinate">Nalorphine dinicotinate</a></li> <li><a href="/wiki/Naloxazone" title="Naloxazone">Naloxazone</a></li> <li><a href="/wiki/Naloxegol" title="Naloxegol">Naloxegol</a></li> <li><a href="/wiki/Naloxol" title="Naloxol">Naloxol</a></li> <li><a href="/wiki/Naloxonazine" title="Naloxonazine">Naloxonazine</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/w/index.php?title=Naltrexazone&action=edit&redlink=1" class="new" title="Naltrexazone (page does not exist)">Naltrexazone</a></li> <li><a href="/w/index.php?title=Naltrexonazine&action=edit&redlink=1" class="new" title="Naltrexonazine (page does not exist)">Naltrexonazine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid</a><br />(DOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/7-Spiroindanyloxymorphone" title="7-Spiroindanyloxymorphone">7-SIOM</a></li> <li><a href="/wiki/ADL-5747" title="ADL-5747">ADL-5747 (PF-04856881)</a></li> <li><a href="/wiki/ADL-5859" title="ADL-5859">ADL-5859</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/w/index.php?title=AR-M100390&action=edit&redlink=1" class="new" title="AR-M100390 (page does not exist)">AR-M100390 (ARM390)</a></li> <li><a href="/wiki/AZD2327" class="mw-redirect" title="AZD2327">AZD2327</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/wiki/BU-48" title="BU-48">BU-48</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/Deltorphin" title="Deltorphin">Deltorphin A</a></li> <li><a href="/wiki/Deltorphin_I" title="Deltorphin I">Deltorphin I</a></li> <li><a href="/w/index.php?title=Deltorphin_II&action=edit&redlink=1" class="new" title="Deltorphin II (page does not exist)">Deltorphin II</a></li> <li><a href="/wiki/Desmethylclozapine" title="Desmethylclozapine">Desmethylclozapine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/DPDPE" title="DPDPE">DPDPE</a></li> <li><a href="/wiki/DPI-221" title="DPI-221">DPI-221</a></li> <li><a href="/wiki/DPI-3290" title="DPI-3290">DPI-3290</a></li> <li><a href="/w/index.php?title=(D-Ser2,_Leu5,_Thr6)-Enkephalin&action=edit&redlink=1" class="new" title="(D-Ser2, Leu5, Thr6)-Enkephalin (page does not exist)">DSLET</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/w/index.php?title=Fentanyl_isothiocyanate&action=edit&redlink=1" class="new" title="Fentanyl isothiocyanate (page does not exist)">FIT</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Isomethadone" title="Isomethadone">Isomethadone</a></li> <li><a href="/wiki/JNJ-20788560" title="JNJ-20788560">JNJ-20788560</a></li> <li><a href="/wiki/KNT-127" title="KNT-127">KNT-127</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/N-Phenethyl-14-ethoxymetopon" title="N-Phenethyl-14-ethoxymetopon">N-Phenethyl-14-ethoxymetopon</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RWJ-394674" title="RWJ-394674">RWJ-394674</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/w/index.php?title=SB-235863&action=edit&redlink=1" class="new" title="SB-235863 (page does not exist)">SB-235863</a></li> <li><a href="/wiki/SNC-80" title="SNC-80">SNC-80</a></li> <li><a href="/w/index.php?title=SNC-162&action=edit&redlink=1" class="new" title="SNC-162 (page does not exist)">SNC-162</a></li> <li><a href="/wiki/TAN-67" title="TAN-67">TAN-67 (SB-205,607)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/C-8813" title="C-8813">Thiobromadol (C-8813)</a></li> <li><a href="/wiki/Tonazocine" title="Tonazocine">Tonazocine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/w/index.php?title=TRV250&action=edit&redlink=1" class="new" title="TRV250 (page does not exist)">TRV250</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li> <li><a href="/wiki/Zenazocine" title="Zenazocine">Zenazocine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/w/index.php?title=Naltrindole-5%27-isothiocyanate&action=edit&redlink=1" class="new" title="Naltrindole-5'-isothiocyanate (page does not exist)">5'-NTII</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/w/index.php?title=Alpha-Santolol&action=edit&redlink=1" class="new" title="Alpha-Santolol (page does not exist)">α-Santolol</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/w/index.php?title=7-Benzylidenenaltrexone&action=edit&redlink=1" class="new" title="7-Benzylidenenaltrexone (page does not exist)">BNTX</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/w/index.php?title=ICI-154129&action=edit&redlink=1" class="new" title="ICI-154129 (page does not exist)">ICI-154129</a></li> <li><a href="/w/index.php?title=ICI-174864&action=edit&redlink=1" class="new" title="ICI-174864 (page does not exist)">ICI-174864</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylnaltrindole&action=edit&redlink=1" class="new" title="Methylnaltrindole (page does not exist)">Methylnaltrindole</a></li> <li><a href="/w/index.php?title=N-Benzylnaltrindole&action=edit&redlink=1" class="new" title="N-Benzylnaltrindole (page does not exist)">N-Benzylnaltrindole</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/w/index.php?title=SDM25N&action=edit&redlink=1" class="new" title="SDM25N (page does not exist)">SDM25N</a></li> <li><a href="/wiki/SoRI-9409" title="SoRI-9409">SoRI-9409</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid</a><br />(KOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/8-Carboxamidocyclazocine" title="8-Carboxamidocyclazocine">8-CAC</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/14-Methoxymetopon" title="14-Methoxymetopon">14-Methoxymetopon</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Allomatrine" class="mw-redirect" title="Allomatrine">Allomatrine</a></li> <li><a href="/w/index.php?title=Apadoline&action=edit&redlink=1" class="new" title="Apadoline (page does not exist)">Apadoline</a></li> <li><a href="/wiki/Asimadoline" title="Asimadoline">Asimadoline</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Big_dynorphin" title="Big dynorphin">Big dynorphin</a></li> <li><a href="/wiki/Bremazocine" title="Bremazocine">Bremazocine</a></li> <li><a href="/wiki/BRL-52537" title="BRL-52537">BRL-52537</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Ciprefadol" title="Ciprefadol">Ciprefadol</a></li> <li><a href="/wiki/CR665" title="CR665">CR665</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/Cyclorphan" title="Cyclorphan">Cyclorphan</a></li> <li><a href="/wiki/Cyprenorphine" title="Cyprenorphine">Cyprenorphine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Difelikefalin" title="Difelikefalin">Difelikefalin</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Dynorphin_B" title="Dynorphin B">Dynorphin B (rimorphin)</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Enadoline" title="Enadoline">Enadoline</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/w/index.php?title=Erinacine_E&action=edit&redlink=1" class="new" title="Erinacine E (page does not exist)">Erinacine E</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fedotozine" title="Fedotozine">Fedotozine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/wiki/GR-89696" title="GR-89696">GR-89696</a></li> <li><a href="/w/index.php?title=GR-103545&action=edit&redlink=1" class="new" title="GR-103545 (page does not exist)">GR-103545</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/HS665" title="HS665">HS665</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/HZ-2" title="HZ-2">HZ-2</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/ICI-199,441" title="ICI-199,441">ICI-199,441</a></li> <li><a href="/wiki/ICI-204,448" title="ICI-204,448">ICI-204,448</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketazocine" title="Ketazocine">Ketazocine</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leumorphin" title="Leumorphin">Leumorphin (dynorphin B-29)</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/LPK-26" title="LPK-26">LPK-26</a></li> <li><a href="/wiki/Lufuradom" title="Lufuradom">Lufuradom</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/w/index.php?title=MB-1C-OH&action=edit&redlink=1" class="new" title="MB-1C-OH (page does not exist)">MB-1C-OH</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Moxazocine" title="Moxazocine">Moxazocine</a></li> <li><a href="/w/index.php?title=MR-2034&action=edit&redlink=1" class="new" title="MR-2034 (page does not exist)">MR-2034</a></li> <li><a href="/w/index.php?title=N-MPPP&action=edit&redlink=1" class="new" title="N-MPPP (page does not exist)">N-MPPP</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalfurafine" title="Nalfurafine">Nalfurafine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Niravoline" title="Niravoline">Niravoline</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Norbuprenorphine-3-glucuronide" title="Norbuprenorphine-3-glucuronide">Norbuprenorphine-3-glucuronide</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Proxorphan" title="Proxorphan">Proxorphan</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Salvinorin_A" title="Salvinorin A">Salvinorin A</a> (<a href="/wiki/Salvia_divinorum" title="Salvia divinorum">salvia</a>)</li> <li><a href="/wiki/Salvinorin_B_ethoxymethyl_ether" class="mw-redirect" title="Salvinorin B ethoxymethyl ether">Salvinorin B ethoxymethyl ether</a></li> <li><a href="/wiki/Salvinorin_B_methoxymethyl_ether" title="Salvinorin B methoxymethyl ether">Salvinorin B methoxymethyl ether</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Spiradoline" title="Spiradoline">Spiradoline (U-62,066)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tifluadom" title="Tifluadom">Tifluadom</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Desipramine" title="Desipramine">desipramine</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/U-50488" title="U-50488">U-50488</a></li> <li><a href="/w/index.php?title=U-54,494A&action=edit&redlink=1" class="new" title="U-54,494A (page does not exist)">U-54,494A</a></li> <li><a href="/wiki/U-69,593" title="U-69,593">U-69,593</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/5%27-Guanidinonaltrindole" title="5'-Guanidinonaltrindole">5'-GNTI</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Buprenorphine/samidorphan" title="Buprenorphine/samidorphan">Buprenorphine/samidorphan</a></li> <li><a href="/wiki/Amentoflavone" title="Amentoflavone">Amentoflavone</a></li> <li><a href="/w/index.php?title=5%27-Acetamidinoethylnaltrindole&action=edit&redlink=1" class="new" title="5'-Acetamidinoethylnaltrindole (page does not exist)">ANTI</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/w/index.php?title=Arodyne&action=edit&redlink=1" class="new" title="Arodyne (page does not exist)">Arodyne</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Aticaprant" title="Aticaprant">Aticaprant</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/w/index.php?title=AZ-MTAB&action=edit&redlink=1" class="new" title="AZ-MTAB (page does not exist)">AZ-MTAB</a></li> <li><a href="/wiki/Binaltorphimine" title="Binaltorphimine">Binaltorphimine</a></li> <li><a href="/wiki/BU09059" title="BU09059">BU09059</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/CERC-501" class="mw-redirect" title="CERC-501">CERC-501 (LY-2456302)</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Icalcaprant" title="Icalcaprant">CVL-354</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/w/index.php?title=DIPPA&action=edit&redlink=1" class="new" title="DIPPA (page does not exist)">DIPPA</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/w/index.php?title=LY-2444296&action=edit&redlink=1" class="new" title="LY-2444296 (page does not exist)">LY-2444296</a></li> <li><a href="/wiki/LY-2459989" title="LY-2459989">LY-2459989</a></li> <li><a href="/w/index.php?title=LY-2795050&action=edit&redlink=1" class="new" title="LY-2795050 (page does not exist)">LY-2795050</a></li> <li><a href="/w/index.php?title=MeJDTic&action=edit&redlink=1" class="new" title="MeJDTic (page does not exist)">MeJDTic</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=ML190&action=edit&redlink=1" class="new" title="ML190 (page does not exist)">ML190</a></li> <li><a href="/w/index.php?title=ML350&action=edit&redlink=1" class="new" title="ML350 (page does not exist)">ML350</a></li> <li><a href="/w/index.php?title=MR-2266&action=edit&redlink=1" class="new" title="MR-2266 (page does not exist)">MR-2266</a></li> <li><a href="/w/index.php?title=N-Fluoropropyl-JDTic&action=edit&redlink=1" class="new" title="N-Fluoropropyl-JDTic (page does not exist)">N-Fluoropropyl-JDTic</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Navacaprant" title="Navacaprant">Navacaprant</a></li> <li><a href="/wiki/Norbinaltorphimine" title="Norbinaltorphimine">Norbinaltorphimine</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/PF-4455242" class="mw-redirect" title="PF-4455242">PF-4455242</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/w/index.php?title=UPHIT&action=edit&redlink=1" class="new" title="UPHIT (page does not exist)">UPHIT</a></li> <li><a href="/wiki/Zyklophin" title="Zyklophin">Zyklophin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a><br />(NOP)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Arg14,Lys15)Nociceptin&action=edit&redlink=1" class="new" title="(Arg14,Lys15)Nociceptin (page does not exist)">(Arg14,Lys15)Nociceptin</a></li> <li><a href="/w/index.php?title=((pF)Phe4)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="((pF)Phe4)Nociceptin(1-13)NH2 (page does not exist)">((pF)Phe<sup>4</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=(Phe1%CE%A8(CH2-NH)Gly2)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2 (page does not exist)">(Phe<sup>1</sup>Ψ(CH<sub>2</sub>-NH)Gly<sup>2</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRWK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRWK-NH2 (page does not exist)">Ac-RYYRWK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRIK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRIK-NH2 (page does not exist)">Ac-RYYRIK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/w/index.php?title=JNJ-19385899&action=edit&redlink=1" class="new" title="JNJ-19385899 (page does not exist)">JNJ-19385899</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/MCOPPB" title="MCOPPB">MCOPPB</a></li> <li><a href="/wiki/MT-7716" title="MT-7716">MT-7716</a></li> <li><a href="/wiki/NNC_63-0532" title="NNC 63-0532">NNC 63-0532</a></li> <li><a href="/wiki/Nociceptin" title="Nociceptin">Nociceptin (orphanin FQ)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-11)&action=edit&redlink=1" class="new" title="Nociceptin (1-11) (page does not exist)">Nociceptin (1-11)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-13)NH2&action=edit&redlink=1" class="new" title="Nociceptin (1-13)NH2 (page does not exist)">Nociceptin (1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Ro64-6198" title="Ro64-6198">Ro64-6198</a></li> <li><a href="/wiki/Ro65-6570" title="Ro65-6570">Ro65-6570</a></li> <li><a href="/wiki/SCH-221510" title="SCH-221510">SCH-221510</a></li> <li><a href="/w/index.php?title=SCH-486757&action=edit&redlink=1" class="new" title="SCH-486757 (page does not exist)">SCH-486757</a></li> <li><a href="/w/index.php?title=SR-8993&action=edit&redlink=1" class="new" title="SR-8993 (page does not exist)">SR-8993</a></li> <li><a href="/wiki/SR-16435" title="SR-16435">SR-16435</a></li> <li><a href="/wiki/Sunobinop" title="Sunobinop">Sunobinop (S-117957)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Nphe1)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Nphe1)Nociceptin(1-13)NH2 (page does not exist)">(Nphe<sup>1</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/w/index.php?title=BAN-ORL-24&action=edit&redlink=1" class="new" title="BAN-ORL-24 (page does not exist)">BAN-ORL-24</a></li> <li><a href="/wiki/BTRX-246040" title="BTRX-246040">BTRX-246040 (LY-2940094)</a></li> <li><a href="/wiki/J-113,397" title="J-113,397">J-113,397</a></li> <li><a href="/wiki/JTC-801" title="JTC-801">JTC-801</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-7)&action=edit&redlink=1" class="new" title="Nociceptin (1-7) (page does not exist)">Nociceptin (1-7)</a></li> <li><a href="/w/index.php?title=Nocistatin&action=edit&redlink=1" class="new" title="Nocistatin (page does not exist)">Nocistatin</a></li> <li><a href="/wiki/SB-612,111" title="SB-612,111">SB-612,111</a></li> <li><a href="/w/index.php?title=SR-16430&action=edit&redlink=1" class="new" title="SR-16430 (page does not exist)">SR-16430</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/w/index.php?title=Trap-101&action=edit&redlink=1" class="new" title="Trap-101 (page does not exist)">Trap-101</a></li> <li><a href="/w/index.php?title=UFP-101&action=edit&redlink=1" class="new" title="UFP-101 (page does not exist)">UFP-101</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Enkephalinase_inhibitor" title="Enkephalinase inhibitor">Enkephalinase inhibitors</a>:</i> <a href="/wiki/Amastatin" title="Amastatin">Amastatin</a></li> <li><a href="/w/index.php?title=BL-2401&action=edit&redlink=1" class="new" title="BL-2401 (page does not exist)">BL-2401</a></li> <li><a href="/wiki/Candoxatril" title="Candoxatril">Candoxatril</a></li> <li><a href="/wiki/Phenylalanine#D-,_L-_and_DL-phenylalanine" title="Phenylalanine"><span style="font-size:85%;">D </span>-Phenylalanine</a></li> <li><a href="/w/index.php?title=Dexecadotril&action=edit&redlink=1" class="new" title="Dexecadotril (page does not exist)">Dexecadotril (retorphan)</a></li> <li><a href="/wiki/Ecadotril" title="Ecadotril">Ecadotril (sinorphan)</a></li> <li><a href="/wiki/Kelatorphan" title="Kelatorphan">Kelatorphan</a></li> <li><a href="/wiki/Racecadotril" title="Racecadotril">Racecadotril (acetorphan)</a></li> <li><a href="/wiki/RB-101" title="RB-101">RB-101</a></li> <li><a href="/wiki/RB-120" title="RB-120">RB-120</a></li> <li><a href="/wiki/RB-3007" title="RB-3007">RB-3007</a></li> <li><a href="/w/index.php?title=Opiorphan&action=edit&redlink=1" class="new" title="Opiorphan (page does not exist)">Opiorphan</a></li> <li><a href="/wiki/Selank" title="Selank">Selank</a></li> <li><a href="/wiki/Semax" title="Semax">Semax</a></li> <li><a href="/wiki/Spinorphin" title="Spinorphin">Spinorphin</a></li> <li><a href="/wiki/Thiorphan" title="Thiorphan">Thiorphan</a></li> <li><a href="/wiki/Tynorphin" title="Tynorphin">Tynorphin</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> <ul><li><i>Propeptides:</i> <a href="/wiki/Lipotropin" title="Lipotropin">β-Lipotropin (proendorphin)</a></li> <li><a href="/wiki/Prodynorphin" title="Prodynorphin">Prodynorphin</a></li> <li><a href="/wiki/Proenkephalin" title="Proenkephalin">Proenkephalin</a></li> <li><a href="/w/index.php?title=Pronociceptin&action=edit&redlink=1" class="new" title="Pronociceptin (page does not exist)">Pronociceptin</a></li> <li><a href="/wiki/Proopiomelanocortin" title="Proopiomelanocortin">Proopiomelanocortin (POMC)</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Kyotorphin" title="Kyotorphin">Kyotorphin</a> (met-enkephalin releaser/degradation stabilizer)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Taxon_identifiers" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Taxon_identifiers" style="font-size:114%;margin:0 4em"><a href="/wiki/Help:Taxon_identifiers" title="Help:Taxon identifiers">Taxon identifiers</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;"><i>Piper methysticum</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><span style="white-space:nowrap;"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a>: <span class="uid"><span class="external"><a href="https://www.wikidata.org/wiki/Q161067" class="extiw" title="wikidata:Q161067">Q161067</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Wikispecies" title="Wikispecies">Wikispecies</a>: <span class="uid"><span class="external"><a href="https://species.wikimedia.org/wiki/Piper_methysticum" class="extiw" title="wikispecies:Piper methysticum">Piper methysticum</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Barcode_of_Life_Data_System" title="Barcode of Life Data System">BOLD</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.boldsystems.org/index.php/TaxBrowser_TaxonPage?taxid=1109787">1109787</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Ecocrop" title="Ecocrop">Ecocrop</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://ecocrop.review.fao.org/ecocrop/srv/en/cropView?id=1713">1713</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Encyclopedia_of_Life" title="Encyclopedia of Life">EoL</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://eol.org/pages/596615">596615</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/EPPO_Code" title="EPPO Code">EPPO</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://gd.eppo.int/taxon/PIPME">PIPME</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Global_Biodiversity_Information_Facility" title="Global Biodiversity Information Facility">GBIF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.gbif.org/species/3086358">3086358</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Germplasm_Resources_Information_Network" title="Germplasm Resources Information Network">GRIN</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://npgsweb.ars-grin.gov/gringlobal/taxonomydetail.aspx?id=28587">28587</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/INaturalist" title="INaturalist">iNaturalist</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://inaturalist.org/taxa/166895">166895</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/International_Plant_Names_Index" title="International Plant Names Index">IPNI</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.ipni.org/n/198437-2">198437-2</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Interim_Register_of_Marine_and_Nonmarine_Genera" title="Interim Register of Marine and Nonmarine Genera">IRMNG</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.irmng.org/aphia.php?p=taxdetails&id=11059660">11059660</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Integrated_Taxonomic_Information_System" title="Integrated Taxonomic Information System">ITIS</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=18313">18313</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Missouri_Botanical_Garden" title="Missouri Botanical Garden">MoBotPF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?taxonid=285095">285095</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/NatureServe" title="NatureServe">NatureServe</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://explorer.natureserve.org/Taxon/ELEMENT_GLOBAL.2.155089/">2.155089</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=130404">130404</a></span></span></li> <li><span style="white-space:nowrap;">NZOR: <span class="uid"><a rel="nofollow" class="external text" href="https://www.nzor.org.nz/names/893f34bb-cfcd-45fb-9357-3cd8710cc865">893f34bb-cfcd-45fb-9357-3cd8710cc865</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Open_Tree_of_Life" title="Open Tree of Life">Open Tree of Life</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://tree.opentreeoflife.org/taxonomy/browse?id=1081778">1081778</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/The_Plant_List" title="The Plant List">Plant List</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.theplantlist.org/tpl1.1/record/kew-2569602">kew-2569602</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Natural_Resources_Conservation_Service#Plants" title="Natural Resources Conservation Service">PLANTS</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://plants.sc.egov.usda.gov/plant-profile/PIME">PIME</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Plants_of_the_World_Online" title="Plants of the World Online">POWO</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://powo.science.kew.org/taxon/urn%3Alsid%3Aipni.org%3Anames%3A198437-2">urn:lsid:ipni.org:names:198437-2</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Tropicos" title="Tropicos">Tropicos</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://legacy.tropicos.org/Name/25001137">25001137</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/World_Flora_Online" title="World Flora Online">WFO</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://list.worldfloraonline.org/wfo-0000486456">wfo-0000486456</a></span></span></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r1038841319">.mw-parser-output .tooltip-dotted{border-bottom:1px dotted;cursor:help}</style></div><div role="navigation" class="navbox authority-control" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Help:Authority_control" title="Help:Authority control">Authority control databases</a>: National <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q161067#identifiers" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, 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