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class="content-header content-container -width--wide -centered"> <div class="tags"> <ul class="tag__list"> <li class="tag__item"> <a class="tag__link" href="/research-and-innovation/topic.aspx?id=1056">COVID-19</a> </li> <li class="tag__item"> <a class="tag__link" href="/research-and-innovation/topic.aspx?id=1114">Gene and Cell Therapy</a> </li> <li class="tag__item"> <a class="tag__link" href="/ophthalmology/specialty.aspx?id=1014">Ophthalmology</a> </li> <li class="tag__item"> <a class="tag__link" href="/research-and-innovation/specialty.aspx?id=1011">Research and Innovation</a> </li> <li class="tag__item"> <a class="tag__link" href="/research-and-innovation/topic.aspx?id=1087">Vaccine</a> </li> </ul> </div> <h1 class="content-header__heading" itemprop="name">Developing a Gene-based Vaccine Candidate for COVID-19</h1> <div class="content-header__metadata"> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2020-05-08" itemprop="datePublished">Published on May 8, 2020 </time> </p> <p data-module="share-links"> </p> <p class="citation"> Originally published in <cite itemprop="citation"><a href="https://www.massgeneral.org/news/press-release/Massachusetts-eye-and-ear-and-massachusett-general-hospital-advancing-novel-experimenta-gene-based-covid19-vaccine-aavcovid">Mass General</a></cite> </p> </div> </div> </header> <div class="-padding--vertical -padding--horizontal"> <div class="layout-columns -width--wide -centered"> <div class="layout-columns__main"> <div class="layout-columns__main__content"> <div class="content-summary"> <h3 class="content-summary__heading">In This Article</h3> <ul> <li>Researchers from Massachusetts General Hospital and Massachusetts Eye and Ear are developing an experimental vaccine candidate against SARS-CoV-2, called AAVCOVID</li> <li>The AAVCOVID strategy uses an adeno-associated viral vector technology to induce immunity in healthy populations</li> <li>The vaccine candidate is currently in preclinical development</li> <li>Clinical studies planned for later this year will determine the safety and efficacy of the approach </li> </ul> </div> <p></p><div class="article__signup-container"> <div class="email-signup-inline__container -background--white"> <style> #email-signup-inline { /* 540px */ background-image: url(/assets/raw/email-signup/cardiovascular-sub-callout.jpg); } @media only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #email-signup-inline { /* 1080 width */ background-image: url(/assets/raw/email-signup/cardiovascular-sub-callout.jpg); } } </style> <div class="content-container -width--wide -centered email-signup-inline__wrapper" 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class="codesection" id="code-538"></div> <form method="post" action="https://massgeneral.tfaforms.net/api_v2/workflow/processor" class="hintsBelow labelsAbove" id="538"> <div class="oneField field-container-D " id="tfa_9-D"> <div aria-live="assertive"> <p class="marketo-signup__error"> Error: Please enter a valid email address. </p> </div> <p class="marketo-signup__input" data-module="label-float"> <label for="email-address"> Email Address </label> <input type="email" id="tfa_9" name="tfa_9" value="" data-marketo="email" > <button class="fat-button" type="submit" data-label="Submit" class="primaryAction" id="submit_button" value="Submit"> <span class="a11y-sr-only">Submit</span> </button> </p> <input type="hidden" id="tfa_10" name="tfa_10" value="Sub_MGB Advances" class=""><input type="hidden" id="tfa_12" name="tfa_12" value="AiM Sub Box" class=""> </div> <div style="clear:both"></div> <input type="hidden" value="538" name="tfa_dbFormId" id="tfa_dbFormId"> <input type="hidden" value="" name="tfa_dbResponseId" id="tfa_dbResponseId"> <input type="hidden" value="2be2ce342ee3a8558d26381d0bdb8739" name="tfa_dbControl" id="tfa_dbControl"> <input type="hidden" value="" name="tfa_dbWorkflowSessionUuid" id="tfa_dbWorkflowSessionUuid"> <input type="hidden" value="2" name="tfa_dbVersionId" id="tfa_dbVersionId"> <input type="hidden" value="" name="tfa_switchedoff" id="tfa_switchedoff"> </form> </div> </div> </div> <script id="open-telemetry-script" type="text/javascript" src="https://massgeneral.tfaforms.net/dist/open-telemetry/open-telemetry.152f594b0ae29ae89d4a.js" data-customer-id="1118" data-exporter-url="https://us-east-1-otel.formassembly.com/v1/traces" data-exporter-console="0" ></script> <script src="https://massgeneral.tfaforms.net/api_v2/sst/copy-and-paste"></script> </div> </div> </div> <p>Researchers from Massachusetts Eye and Ear and Massachusetts General Hospital have developed a vaccine candidate for COVID-19, which they plan to test in humans within the year.</p> <p>The vaccine, called AAVCOVID, is the product of a unique, gene-based approach that uses adeno-associated viral (AAV) vector technology to help the body develop an immune response to the virus.</p> <p>The AAVCOVID vaccine program was developed in the laboratory of <a href="https://advances.massgeneral.org/contributors/contributor.aspx?id=1916" target="_blank" rel="noopener noreferrer">Luk H. Vandenberghe, PhD</a>, director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear. Work in the laboratory began in mid-January after the first research papers on the coronavirus outbreak in Wuhan were published.</p> <p>AAV technology delivers genetic sequences of the SARS-CoV-2 using an AAV vector as a vehicle into the body. The technology has been used extensively in the field of gene therapy, and in recent years, two AAV-based drugs have been approved by the FDA.</p> <p>Dr. Vandenberghe says that AAV is a superior technology for safe and efficient gene delivery. He continues that the unique technologies being applied in AAVCOVID support the potential for a potent immunity against SARS-CoV-2 from a single intramuscular injection.</p> <p>Tests are currently underway in animal models, and a plan is in place to begin clinical testing in humans later this year.</p> <p><a href="https://advances.massgeneral.org/contributors/contributor.aspx?id=1645" target="_blank" rel="noopener noreferrer">Mason Freeman, MD,</a> director and founder of the <a href="https://www.massgeneral.org/research/division-clinical-research/centers-units-and-faculty/centers/translational-research-center" target="_blank" rel="noopener noreferrer">Mass General Translational Research Center</a>, is leading the effort to develop a clinical study to establish safety and efficacy of the experimental vaccine. Dr. Freeman described the vaccine candidate as an elegant and extremely creative approach that is designed to protect vulnerable patients as well as the health care workers who care for them.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p><p class="fat-link__wrapper u-text-right"> <a class="fat-link -caret -large" href="https://www.massgeneral.org/news/press-release/Massachusetts-eye-and-ear-and-massachusett-general-hospital-advancing-novel-experimenta-gene-based-covid19-vaccine-aavcovid">Read More on Mass General</a> </p> <p class="cta">View all <a href="https://advances.massgeneral.org/research-and-innovation/topic.aspx?id=1056">COVID-19 updates</a></p> <p class="cta">Learn more about <a href="https://www.massgeneral.org/news/coronavirus/research/">COVID-19 research at Mass General</a></p> </div> </div> <aside class="layout-columns__sidebar -article__contributors"> <div class="layout-columns__sidebar__content"> <div class="profile-compact__wrapper"> <p class="u-no-margin"> <strong>Contributors</strong> </p> <div class="profile -compact" itemscope itemtype="http://schema.org/Person"> <div class="profile__content"> <h3 class="profile__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1916" itemprop="url">Luk Vandenberghe, PhD ›</a></h3><p class="profile__title" itemprop="jobTitle">Associate Professor of Ophthalmology, Harvard Medical School, Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear</p> </div> <p class="profile__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/luk_vandenberghe2_advances.png, /assets/images/contributors/luk_vandenberghe2_advances_2x.png 2x" src="/assets/images/contributors/luk_vandenberghe2_advances.png"> </p> </div> <div class="profile -compact" itemscope itemtype="http://schema.org/Person"> <div class="profile__content"> <h3 class="profile__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1645" itemprop="url">Mason Wright Freeman, MD ›</a></h3><p class="profile__title" itemprop="jobTitle">Director and Founder, Mass General Translational Research Center</p> </div> </div> </div> </div> </aside> <section class="topics-layout -article__related"> <div class="topics-layout__inner"> <div class="topics-layout__sidebar"> <h2 class="section-heading">Related topics</h2> </div> <div class="topics-layout__main"> <ul class="topics-list" data-module="topics-list"> <li><a href="/research-and-innovation/topic.aspx?id=1056">COVID-19</a></li> <li><a href="/research-and-innovation/topic.aspx?id=1114">Gene and Cell Therapy</a></li> <li><a href="/research-and-innovation/topic.aspx?id=1087">Vaccine</a></li> </ul> </div> </div> </section> <section class="-padding--horizontal -padding--vertical -article__related"> <div class="layout-columns -width--wide -centered"> <div class="layout-columns__pod--half"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Related</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/research-and-innovation/article.aspx?id=1187" itemprop="url">Update on Use of Hydroxychloroquine to Treat COVID-19: Q&A with Raghu Chivukula, MD, PhD</a> </h3> <p itemprop="description"> <p></p> <p></p> <p>Recently, based on clinical data, the FDA and the NIH have each released formal statements expressing concern regarding the safety and efficacy of hydroxychloroquine and chloroquine. In his second Q&A on the subject, Raghu Chivukula, MD, PhD, gives an update on the use of these drugs to treat COVID-19.</p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p> <p></p></p> <p class="content-tease__related"> <a href="/cardiovascular/specialty.aspx?id=1002" itemprop="relatedLink">Cardiovascular</a>, <a href="/research-and-innovation/topic.aspx?id=1056" itemprop="relatedLink">COVID-19</a>, <a href="/pulmonary/specialty.aspx?id=1012" itemprop="relatedLink">Pulmonary and Critical Care</a>, <a href="/research-and-innovation/specialty.aspx?id=1011" itemprop="relatedLink">Research and Innovation</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2020-04-29" itemprop="datePublished">April 29, 2020</time> </p> </div> </div> <div class="layout-columns__pod--half"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Related</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/research-and-innovation/article.aspx?id=1190" itemprop="url">Identifying SARS-CoV-2 Antibodies to Detect Immunity</a> </h3> <p itemprop="description"> <p>As the COVID-19 pandemic continues to evolve around the globe, researchers at Massachusetts General Hospital are identifying antibodies that provide immunity against the SARS-CoV-2 virus.</p></p> <p class="content-tease__related"> <a href="/research-and-innovation/topic.aspx?id=1056" itemprop="relatedLink">COVID-19</a>, <a href="/research-and-innovation/specialty.aspx?id=1011" itemprop="relatedLink">Research and Innovation</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2020-05-01" itemprop="datePublished">May 1, 2020</time> </p> </div> </div> </div> </section> </div> 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