Multiple Myeloma | Mission Bio

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href="https://missionbio.com/applications/oncology/">Oncology Research</a></span> <span class="bread-arrow"></span> <span class="breadcrumb_last" aria-current="page">Multiple Myeloma</span></span></div></div> <section id="multiple-myeloma-hero" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/MBIO_HomepageBanner_MultipleMyeloma.jpg')" class="dark_mobile"> <div class="_1300-container inner-content"> <div class="apps-cols"> <div class="mission-copy"> <h1 class="h2-thin nm w">Get the whole picture—down to the single-cell level</h1> <div class="description"><p>Introducing the Tapestri Single-cell Multiple Myeloma Multiomics Solution</p> </div> <a style="color: #ffffff; margin: 30px 0 0 0; padding-top: 9px; padding-bottom: 9px;" class="button" href="/company/contact/" target="">Talk to a scientist</a> </div> </div> </div> </section> <section id="multiple-myeloma-panels-categories"> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#multiple-myeloma-critical_moments" class="cap-link">KEY BENEFITS</a> <a href="#Directly-Correlate" class="cap-link">DATA</a> <a href="#multiple_myeloma-assay_content" class="cap-link">ASSAY CONTENT</a> <a href="#multiple_myeloma-workflow" class="cap-link">WORKFLOW</a> <a href="#applications-resources" class="cap-link">RESOURCES</a> <a href="#get_started" class="cap-link">GET STARTED</a> </div> </div> </div> </section> <section id="multiple-myeloma-critical_moments"> <div class="_1300-container inner-content"> <h2 class="section_title">Track Cancer’s Most Critical Moments</h2> <div class="description"><p>Numerous genomic events and complex clonality in multiple myeloma (MM) render it a challenging disease with a high relapse rate despite advancements in therapies and diagnostic approaches.</p> <p>Tapestri single-cell multiomics analysis transforms how you understand the complexities of multiple myeloma and its precursor stages by integrating genomic, proteomic, and clonotypic subclonal assessment with single-cell resolution, all within a single assay.</p> <p>With the Tapestri Single-cell Multiple Myeloma Multiomics Solution, you gain crucial insights into the clonal and subclonal heterogeneity underlying myeloma progression, therapy response, and relapse often missed by traditional bulk methods, potentially improving the identification of novel biomarkers and the development of better therapies.</p> </div> <div class="advantages-cols flex"> <div class="advantages-card flex_25"> <div class="advantages-info"> <div class="border-right"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-121.svg" alt="" class="app-icon"> </div> <h4 class="name">Hotspot Mutations in Driver & Resistance Genes</h4> </div> <div class="description"><p>Assess clonal heterogeneity & evolution in multiple myeloma (includes SNV and focal CNA)</p> </div> </div> </div> <div class="advantages-card flex_25"> <div class="advantages-info"> <div class="border-right"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-112.svg" alt="" class="app-icon"> </div> <h4 class="name">Zygosity</h4> </div> <div class="description"><p>Discern zygosity of detected mutations impacting disease progression or drug resistance</p> </div> </div> </div> <div class="advantages-card flex_25"> <div class="advantages-info"> <div class="border-right"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-122.svg" alt="" class="app-icon"> </div> <h4 class="name">Genome-wide  CNV</h4> </div> <div class="description"><p>Analyze whole  genome copy number gains and losses</p> </div> </div> </div> <div class="advantages-card flex_25"> <div class="advantages-info"> <div class="border-right"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-117.svg" alt="" class="app-icon"> </div> <h4 class="name">V(D)J Clonotyping</h4> </div> <div class="description"><p>Identify Ig clonotype in the CDR3 region</p> </div> </div> </div> <div class="advantages-card flex_25"> <div class="advantages-info"> <div class="border-right"> <div class="image"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-118.svg" alt="" class="app-icon"> </div> <h4 class="name">Surface  Immunophenotype</h4> </div> <div class="description"><p>Classify cell types and identify immunotherapy targets such as BCMA and FcRH5</p> </div> </div> </div> </div> </div> </section> <section id="multiple-myeloma-primary_applications" class="primary_applications_section"> <div class="_1300-container inner-content key-benefits"> <h2 class="section_title">Primary Applications</h2> <div class="applications-cols"> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/Rectangle-127.png')"> <div class="applications-info"> <div class="applications-info__heading"> <h4 class="name">Understand Disease Evolution From MGUS or SMM</h4> <div class="description"><ul> <li>Assess the clonality driving myeloma transformation</li> <li>Pinpoint subclonal drivers of disease evolution before clinical indicators appear</li> <li>Understand therapy response mechanisms to study early intervention</li> </ul> </div> </div> </div> </div> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/Rectangle-127.png')"> <div class="applications-info"> <div class="applications-info__heading"> <h4 class="name">Immunotherapy Development & Optimization</h4> <div class="description"><ul> <li>Identify heterogeneity of druggable targets (e.g. BCMA, FcRH5)</li> <li>Elucidate mechanisms of resistance to therapies like CAR-T & bispecifics</li> <li>Determine the zygosity of mutations linked to MM progression or drug resistance</li> </ul> <p>Learn about our cell therapy characterization solution.</p> </div> </div> <a class="button" href="/applications/cell-and-gene-therapy/" target=""">LEARN MORE <svg xmlns="http://www.w3.org/2000/svg" width="16" height="8" viewBox="0 0 16 8" fill="none"> <path d="M0.5 4.5C0.223858 4.5 -3.54637e-08 4.27614 0 4C5.66101e-09 3.72386 0.223858 3.5 0.5 3.5L0.5 4.5ZM15.8536 3.64645C16.0488 3.84171 16.0488 4.15829 15.8536 4.35355L12.6716 7.53553C12.4763 7.73079 12.1597 7.73079 11.9645 7.53553C11.7692 7.34027 11.7692 7.02369 11.9645 6.82843L14.7929 4L11.9645 1.17157C11.7692 0.976309 11.7692 0.659727 11.9645 0.464465C12.1597 0.269202 12.4763 0.269203 12.6716 0.464465L15.8536 3.64645ZM0.5 3.5L15.5 3.5L15.5 4.5L0.5 4.5L0.5 3.5Z" fill="#53B4D3"/> </svg> </a> </div> </div> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/Rectangle-38.png')"> <div class="applications-info"> <div class="applications-info__heading"> <h4 class="name">Understand Disease Biology Using Cancer Models</h4> <div class="description"><ul> <li>Recapitulate MM in mouse or humanized models to uncover molecular pathogenesis</li> <li>Assess clonal heterogeneity & evolution in preclinical models</li> <li>Discover druggable targets and identify promising drug candidates</li> </ul> </div> </div> </div> </div> </div> </div> </section> <section id="multiple-myeloma-webinar" class="multiple_myeloma_webinar"> <div class="_1300-container inner-content key-benefits"> <div class="multiple_myeloma_webinar__block"> <div class="left"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Ellipse-6.png" alt=""> </div> <div class="right"> <h4 class="title_with_border">FEATURED WEBINAR</h4> <h2 class="title">From Stealth to Spotlight</h2> <div class="subtitle">Single-Cell Identification of SMM Clones Driving Myeloma Progression and Therapy Resistance</div> <div class="description"><p>Learn how to identify <span style="font-weight: 400;">smoldering multiple myeloma (SMM)</span> clonal populations progressing to active myeloma or resistant disease with a true multiomics platform that can quantitatively correlate multiple features from SMM subclones including SNVs, genome-wide CNVs, Ig clonotype, and surface protein expression.</p> </div> <div class="position"><p>Featuring Adam Sciambi, PhD<br /> CTO, Mission Bio</p> </div> <a class="button" href="/resources/presentations/single-cell-multiple-myeloma/" target="_blank">WATCH THE WEBINAR</a> </div> </div> </div> </section> <section id="multiple_myeloma-directly-correlate" class="panels-section st"> <div id="Directly-Correlate" class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Directly Correlate Molecular Signatures of Multiple Myeloma at the Clonal Level</h2> <p class="mb30-copy _60"> <p>Tapestri automatically generates comprehensive and intuitive reports with data visualizations to help you easily correlate various clonal and subclonal attributes.</p> </p> <a class="button" href="/wp-content/uploads/2024/10/MM01_4.html" target=""">SEE AN EXAMPLE REPORT</a> </div> </section> <section id="applications-genome-tapestri"> <div class="_1300-container inner-content"> <h2 class="section_title">Tapestri Single-cell Myeloma Multiomics Solution</h2> <div class="subtitle">Get everything you need to conduct single-cell multiomics analysis of multiple myeloma samples in your lab with this fully-supported, all-in-one package.</div> <div class="info"> <ul> <li>Tapestri Instrument</li> <li>Tapestri Single-cell Multiple Myeloma Multiomics Kit including: <ul> <li>DNA + Protein Core Kit</li> <li>Multiple Myeloma DNA Panel</li> <li>Genome-Wide CNV Panel</li> <li>Multiple Myeloma Antibody Cocktail</li> </ul> </li> <li>Software-Based Analysis (via Portal Access or On-Premise Activation)</li> <li>Sample Multiplexing by Genotyping</li> </ul> <img class="info_image" src="https://missionbio.com/wp-content/uploads/2024/06/image-12.png" alt=""> </div> <div class="description"> </div> </div> </section> <section id="multiple_myeloma-assay_content" class="multiple_myeloma-assay_content"> <div class="_1300-container inner-content"> <h2 class="section_title">Assay Content</h2> <div class="description"><p>• Coverage of key driver and resistance genes, genome-wide copy number variations (CNVs), V(D)J clonotype, and cell lineage & immunotherapy markers</p> <p>• Available to purchase as a complete solution or as standalone panels</p> </div> </div> </section> <section id="multiple_myeloma-overview" class="multiple_myeloma-overview"> <div class="_1300-container inner-content"> <div class="sub_info"> <h2 class="section_title">Overview of Tapestri Single-Cell Multiple Myeloma Multiomics Assay Content</h2> <div class="description"></div> <h3></h3> <div class="table_block_overflow"> <div class="table_block"> <div class="table_block__item table_block__item_head"> <div class="table_block__item_first">Panel</div> <div class="table_block__item_second">Analyte(s)</div> <div class="table_block__item_third">Targets covered</div> </div> <div class="table_block__item table_block__item_content"> <div class="table_block__item_first">Tapestri Single-Cell DNA Multiple Myeloma Panel</div> <div class="table_block__item_second_and_third"> <div class="table_block__item_second_and_third__item"> <div class="table_block__item_second"> Hotspot mutations in driver & resistance genes </div> <div class="table_block__item_third"> 47 genes associated with multiple myeloma and therapy resistance </div> </div> <div class="table_block__item_second_and_third__item"> <div class="table_block__item_second"> Focal copy number aberrations (CNA) </div> <div class="table_block__item_third"> 10 genes with focal copy number aberrations </div> </div> <div class="table_block__item_second_and_third__item"> <div class="table_block__item_second"> V(D)J clonotype </div> <div class="table_block__item_third"> CDR3 region of the IgH, IgK, and IgL chains </div> </div> </div> </div> <div class="table_block__item table_block__item_content"> <div class="table_block__item_first">Tapestri Single-Cell DNA Genome-Wide CNV Panel</div> <div class="table_block__item_second_and_third"> <div class="table_block__item_second_and_third__item"> <div class="table_block__item_second"> Genome-wide copy number variations </div> <div class="table_block__item_third"> All chromosome arms except chrY </div> </div> </div> </div> <div class="table_block__item table_block__item_content"> <div class="table_block__item_first">TotalSeq-D Multiple Myeloma Antibody Cocktail</div> <div class="table_block__item_second_and_third"> <div class="table_block__item_second_and_third__item"> <div class="table_block__item_second"> Cell surface antigens </div> <div class="table_block__item_third"> 19-plex antibody oligonucleotide conjugates targeting cell lineage markers & therapeutic targets </div> </div> </div> </div> </div> </div> </div> </div> </section> <section id="multiple_myeloma-accordion" class="multiple_myeloma-assay_content"> <div class="_1300-container inner-content"> <div class="accordion_block" id="accordion_block"> <h2 class="section_title">Details of Each Panel</h2> <div class="accordion"> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #717171">Single-сell DNA Multiple Myeloma Panel <div class="plus_icon"> <span class="line1" style="background: #717171"></span> <span class="line2" style="background: #717171"></span> </div> </div> </div> <div class="accordion-content accordion-content__with_tabs"> <div class="navtabs"> <div class="navtab active" data-target="navtab1">Hotspot Mutations</div> <div class="navtab " data-target="navtab2">Resistance Mutations</div> <div class="navtab " data-target="navtab3">Focal CNA</div> <div class="navtab " data-target="navtab4">V(D)J Clonotype</div> </div> <div class="contenttabs"> <div id="navtab1" class="content active"> <h4>34 genes with hotspot mutations</h4> <div class="description"><p>Drivers genes commonly associated with multiple myeloma curated based on<br /> consultation with global experts and publications</p> </div> <div class="table"> <div class="row"> <div class="cell cell_0"> <p>ACTG1</p> </div> <div class="cell cell_1"> <p>ATM</p> </div> <div class="cell cell_2"> <p>BRAF</p> </div> <div class="cell cell_3"> <p>CCND1</p> </div> <div class="cell cell_4"> <p>CCND3</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>CDKN1B</p> </div> <div class="cell cell_1"> <p>CDKN2C</p> </div> <div class="cell cell_2"> <p>CYLD</p> </div> <div class="cell cell_3"> <p>DIS3</p> </div> <div class="cell cell_4"> <p>EGR1</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>EZH2</p> </div> <div class="cell cell_1"> <p>FAM46C</p> </div> <div class="cell cell_2"> <p>FGFR3</p> </div> <div class="cell cell_3"> <p>IDH1</p> </div> <div class="cell cell_4"> <p>IDH2</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>IKFZ1</p> </div> <div class="cell cell_1"> <p>IRF4</p> </div> <div class="cell cell_2"> <p>KRAS</p> </div> <div class="cell cell_3"> <p>LTB</p> </div> <div class="cell cell_4"> <p>MAF</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>MAX</p> </div> <div class="cell cell_1"> <p>MYC</p> </div> <div class="cell cell_2"> <p>NFKBIA</p> </div> <div class="cell cell_3"> <p>NRAS</p> </div> <div class="cell cell_4"> <p>PRDM1</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>PTPN11</p> </div> <div class="cell cell_1"> <p>RB1</p> </div> <div class="cell cell_2"> <p>SF3B1</p> </div> <div class="cell cell_3"> <p>SLAMF7</p> </div> <div class="cell cell_4"> <p>SP140</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>TP53</p> </div> <div class="cell cell_1"> <p>TRAF2</p> </div> <div class="cell cell_2"> <p>TRAF3</p> </div> <div class="cell cell_3"> <p>XBP1</p> </div> <div class="cell cell_4"> </div> </div> </div> <style> #navtab1 .cell_0 { width: 20%; } </style> <style> #navtab1 .cell_1 { width: 20%; } </style> <style> #navtab1 .cell_2 { width: 20%; } </style> <style> #navtab1 .cell_3 { width: 20%; } </style> <style> #navtab1 .cell_4 { width: 20%; } </style> </div> <div id="navtab2" class="content "> <h4>13 genes with resistance mutations</h4> <div class="description"><p>Genes associated with therapy resistance in multiple myeloma curated based on consultation with global experts and publications.</p> </div> <div class="table"> <div class="row"> <div class="cell cell_0"> <p>CD38</p> </div> <div class="cell cell_1"> <p>CRBN</p> </div> <div class="cell cell_2"> <p>CUL4B</p> </div> <div class="cell cell_3"> <p>FCRL5</p> </div> <div class="cell cell_4"> <p>FRG1</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>FRMPD3</p> </div> <div class="cell cell_1"> <p>GPRC5D</p> </div> <div class="cell cell_2"> <p>NR3C1</p> </div> <div class="cell cell_3"> <p>OGT</p> </div> <div class="cell cell_4"> <p>RARA</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>TNFRSF17</p> </div> <div class="cell cell_1"> <p>TRAPPC8</p> </div> <div class="cell cell_2"> <p>UNC13C</p> </div> <div class="cell cell_3"> </div> <div class="cell cell_4"> </div> </div> </div> <style> #navtab2 .cell_0 { width: 20%; } </style> <style> #navtab2 .cell_1 { width: 20%; } </style> <style> #navtab2 .cell_2 { width: 20%; } </style> <style> #navtab2 .cell_3 { width: 20%; } </style> <style> #navtab2 .cell_4 { width: 20%; } </style> </div> <div id="navtab3" class="content "> <h4>10 genes with focal copy number aberrations</h4> <div class="description"><p>Genes with focal CNAs commonly associated with multiple myeloma curated based on consultation with global experts and publications.</p> </div> <div class="table"> <div class="row"> <div class="cell cell_0"> <p>ATM / BIRC2/3<br /> (11q22.3)</p> </div> <div class="cell cell_1"> <p>CDKN2A/9<br /> (9p21.3)</p> </div> <div class="cell cell_2"> <p>CDKN2C<br /> (1p32.3)</p> </div> <div class="cell cell_3"> <p>EVI5 / RPL5<br /> (1p22.3)</p> </div> <div class="cell cell_4"> <p>FAM46C /<br /> TENT5C<br /> (1p12)</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>GPRC5D /<br /> CDKN1B<br /> (12p13.1)</p> </div> <div class="cell cell_1"> <p>MYC<br /> (8q24.21)</p> </div> <div class="cell cell_2"> <p>RB1<br /> (13q14.2)</p> </div> <div class="cell cell_3"> <p>TNFRSF17<br /> (16p13.13)</p> </div> <div class="cell cell_4"> <p>TP53<br /> (17p13.1)</p> </div> </div> </div> <style> #navtab3 .cell_0 { width: 20%; } </style> <style> #navtab3 .cell_1 { width: 20%; } </style> <style> #navtab3 .cell_2 { width: 20%; } </style> <style> #navtab3 .cell_3 { width: 20%; } </style> <style> #navtab3 .cell_4 { width: 20%; } </style> </div> <div id="navtab4" class="content "> <h4>V(D)J Clonotype</h4> <div class="description"><p>Forward and reverse primers targeting the CDR3 region of the IgH, IgK, and IgL chains.</p> </div> <div class="table"> <div class="row"> <div class="cell cell_0"> <p><strong>Targets</strong></p> </div> <div class="cell cell_1"> <p><strong>No. of forward / reverse primers</strong></p> </div> <div class="cell cell_2"> <p><strong>No. of V/J genes targeted</strong></p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>BCR-IGH</p> </div> <div class="cell cell_1"> <p>38/5</p> </div> <div class="cell cell_2"> <p>8 V subgroups (447/450 alleles)</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>BCR-IGk</p> </div> <div class="cell cell_1"> <p>15/4</p> </div> <div class="cell cell_2"> <p>6 J subgroups (13/13 alleles)</p> </div> </div> <div class="row"> <div class="cell cell_0"> <p>BCR-IGL</p> </div> <div class="cell cell_1"> <p>20/5</p> </div> <div class="cell cell_2"> <p>7 V subgroups (126/126 alleles)</p> </div> </div> </div> <style> #navtab4 .cell_0 { width: 20%; } </style> <style> #navtab4 .cell_1 { width: 20%; } </style> <style> #navtab4 .cell_2 { width: 60%; } </style> </div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #53B4D3">Single-cell DNA Genome-wide CNV Panel <div class="plus_icon"> <span class="line1" style="background: #53B4D3"></span> <span class="line2" style="background: #53B4D3"></span> </div> </div> </div> <div class="accordion-content accordion-content__without_tabs"> <h4>Genome-wide copy number variations</h4> <div class="description"><p>500 amplicon panel uniformly covering nearly the entire genome.</p> </div> <div class="two_column"> <div class="left"> <img src="https://missionbio.com/wp-content/uploads/2024/10/unnamed.png" alt=""> </div> <div class="right"> </div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-title"> <div class="title" style="background: #EB2334">TotalSeq-D Multiple Myeloma Antibody Cocktail <div class="plus_icon"> <span class="line1" style="background: #EB2334"></span> <span class="line2" style="background: #EB2334"></span> </div> </div> </div> <div class="accordion-content accordion-content__without_tabs"> <h4>19 antibody oligonucleotide conjugates (AOCs)</h4> <div class="description"><p>Surface antigen makers for cell type classification and therapeutic target identification.</p> </div> <div class="two_column"> <div class="left"> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-146.svg" alt=""> </div> <div class="right"> <h5><p>Emerging targets for immunotherapy covered by our assay</p> </h5> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-145.svg" alt=""> </div> </div> </div> </div> </div> </div> </div> </section> <section id="multiple_myeloma-workflow" class="multiple_myeloma-workflow"> <div class="_1300-container inner-content"> <div class="title_with_image_external"> <div class="title_with_image"> <h2 class="section_title">The Tapestri Multiple Myeloma Workflow</h2> <img src="https://missionbio.com/wp-content/uploads/2024/06/Group-142.png" alt=""> </div> </div> <div class="description"><p>Our streamlined multiple myeloma workflow allows you to multiplex bone marrow samples on the Tapestri Platform, sequence the libraries on an NGS platform, and then easily analyze the results using the Tapestri Multiple Myeloma Software. The Solution can integrate SNVs, focal CNAs, genome-wide CNVs, V(D)J clonotype, and immunophenotype.</p> </div> </div> </section> <section id="multiple_myeloma-partnering" class="panels-section st"> <div id="Partnering" class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Partnering with Mission Bio</h2> <p class="mb30-copy _60"> <p>To support you and your drug development, we provide full service as a strategic partner for you from single-cell assay design, sample processing, through to data analysis and visualization. Whether we offer services internally or in partnership with qualified CROs, we are dedicated to the accelerated success of your drug development programs.</p> </p> <img src="https://missionbio.com/wp-content/uploads/2024/06/2RlqzL.png" loading="lazy" alt="Three icons including a light bulb and a data chart, a correlation graph, and a physician" class="partnering-image"> <a class="button" href="/products/pharma-assay-development/" target=""">LEARN MORE ABOUT PAD</a> </div> </section> <section id="applications-resources" class="h-resources" style=""> <div class="_1300-container inner-content"> <h2 class="section_title w" style="">Featured Resources </h2> <div class="h-resources-grid"> <div class="h-resource-card sp" data-ix="show-more-link"> <div class="h-resource-image sp" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/scientific-presentations-card-image-v2.png);"></div> <div class="h-resource-content"> <div class="h-resource-category d sp"> SCIENTIFIC PRESENTATION </div> <a href="https://missionbio.com/resources/presentations/panel-discussion-aml-mm-single-cell-multiomics/" class="h-resource-title-link"> From Cells to Cures: Panel Discussion on Advancing Clonal Profiling in Leukemia & Myeloma With Single-Cell Multiomics </a> <br/> <a href="https://missionbio.com/resources/presentations/panel-discussion-aml-mm-single-cell-multiomics/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn"> PUBLICATION </div> <a href="https://missionbio.com/resources/publications/ras-raf-landscape-in-monoclonal-plasma-cell-conditions/" class="h-resource-title-link"> RAS/RAF landscape in monoclonal plasma cell conditions </a> <br/> <a href="https://missionbio.com/resources/publications/ras-raf-landscape-in-monoclonal-plasma-cell-conditions/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card p" data-ix="show-more-link"> <div class="h-resource-image p" style="background-image: url(/wp-content/themes/missionbio-v2/images-2/Posters.png);"></div> <div class="h-resource-content"> <div class="h-resource-category d pt">posters</div> <a href="https://missionbio.com/resources/posters/single-cell-multiomic-clonal-tracking-in-myeloma-identifies-smm-clones-that-progress-to-mm-and-low-frequency-mm-clones-with-resistance-features-enabling-more-precise-application-of-targeted-therapies/" class="h-resource-title-link"> Single-cell Multiomic Clonal Tracking in Myeloma Identifies SMM Clones that Progress to MM and Low-Frequency MM Clones with Resistance Features Enabling More Precise Application of Targeted Therapies </a> <br/> <a href="https://missionbio.com/resources/posters/single-cell-multiomic-clonal-tracking-in-myeloma-identifies-smm-clones-that-progress-to-mm-and-low-frequency-mm-clones-with-resistance-features-enabling-more-precise-application-of-targeted-therapies/" class="more-link">LEARN MORE</a> </div> </div> </div> </div> </section> <section id="get_started" class="mrd-get_started"> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Get Started</h3> <div class="mb30 w"><p>Contact us to begin your evaluation</p> </div> <a href="/company/contact/" class="button w wo r w-button">CONTACT US</a> <div class="mb30 w get_started_bottom_description"><p>For Research Use Only. 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