Tapestri Single-cell Sequencing Platform

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aria-current="page">Tapestri Platform</span></span></div></div> <div class="instrument-hero old"> <div class="_1300-container inner-content platform-old"> <div class="panels-cols"> <div class="mission-copy old"> <h1 class="h2-thin nm w">Using a Single Cell Sequencing Platform to Untangle the Complexity of Cancer with a True Multi-Omics Approach.</h1> <div class="panel-sub">Gain the true single-cell picture to enable precise understanding</div> <p class="mb30">The Tapestri Platform is the only system capable of simultaneously providing both genotype and phenotype data from the same cell, across thousands of single cells. With DNA as a foundation, our proprietary two-step microfluidic workflow enables the simultaneous detection of analytes, including SNVs, CNVs, and proteins. Meet the complexity of cancer with true multi-omics analysis.</p> <a href="https://fast.wistia.net/embed/iframe/ibprppwa0s?autoplay=true" class="button w-button video-link v-lightbox" style="color: #fff; display: inline-block; width: auto;"> View Video </a> <div class="secondary-ctas"> <a href="/resources/technical-notes/protein-correlations-application-note/" class="more-link show">Download App Note</a> </div> </div> <div class="instrument-image"> <img src="/wp-content/themes/missionbio-v2/images-2/products/platform/tapestri-instrument-only-hero-black.jpg" srcset="/wp-content/themes/missionbio-v2/images-2/products/platform/tapestri-instrument-only-hero-black-500.jpg 500w, /wp-content/themes/missionbio-v2/images-2/products/platform/tapestri-instrument-only-hero-black.jpg 800w" sizes="(max-width: 479px) 87vw, (max-width: 767px) 83vw, (max-width: 991px) 32vw, 500px" alt="Tapestri instrument product image" class="instrument"> </div> </div> </div> </div> <div class="panels-categories"> <div class="_1300-container inner-content panel-catego"> <div class="panels-links"> <a href="#Benefits" class="cap-link">Key Benefits</a> <a href="#Workflow" class="cap-link">Workflow</a> <a href="#Tapestri" class="cap-link">Library Prep</a> <a href="#Reagents" class="cap-link">REAGENTS</a> <a href="#Software" class="cap-link">Software</a> <a href="#Resources" class="cap-link">Resources</a></div> </div> </div> <div id="Benefits" class="panels-section platform"> <div class="_1300-container inner-content key-benefits"> <img src="/wp-content/themes/missionbio-v2/images-2/products/platform/MBIO_instrument-box-monitor-SNV-transparent.png" srcset="/wp-content/themes/missionbio-v2/images-2/products/platform/MBIO_instrument-box-monitor-SNV-transparent.png 500w, /wp-content/themes/missionbio-v2/images-2/products/platform/MBIO_instrument-box-monitor-SNV-transparent.png 800w, /wp-content/themes/missionbio-v2/images-2/products/platform/MBIO_instrument-box-monitor-SNV-transparent.png 1080w, /wp-content/themes/missionbio-v2/images-2/products/platform/MBIO_instrument-box-monitor-SNV-transparent.png 1600w" sizes="(max-width: 479px) 87vw, (max-width: 767px) 83vw, 600px" alt="Tapestri product image with an instrument, reagent kit and analysis software displaying a fish plot" class="platform-image"> <div class="benefits-cols"> <div class="benefits-card"> <div class="benefit-content no-lines"> <div class="icon-title">Two steps. DNA + any analyte. Endless possibilities.</div> <div>Our novel two-step microfluidic workflow is foundational to access DNA and protein in single cells, providing a true multi-omics picture. Combining two assays in a single integrated workflow saves costs and time, accelerating research and drug development pipelines.</div> </div> </div> <div class="benefits-card"> <div class="benefit-content no-lines"> <div class="icon-title">Targeted and customizable.</div> <div>Leverage curated pre-designed panels of DNA and surface protein targets, or create custom panels to suit your needs. Our optimized AI design pipeline will ensure a panel with high uniformity delivered in just weeks.</div> </div> </div> <div class="benefits-card"> <div class="benefit-content no-lines"> <div class="icon-title">Confidence in a comprehensive <span style="white-space: nowrap;">end-to-end</span> workflow.</div> <div>With core reagent and cartridge kits to take you from single cells to a sequencing-ready library, leverage optimized analysis tools to convert your complex multi-dimensional, multi-analyte data to actionable insights.</div> </div> </div> </div> </div> </div> <div id="Workflow" class="panels-section"> <div id="Workflow" class="_1300-container inner-content key-benefits"> <h2 class="h2 c">The Complete Tapestri Workflow</h2> <p class="highlight-heading">Integrate seamlessly into your existing NGS workflow with sample prep and analysis solutions using the Tapestri single-cell sequencing platform</p> <div>With our single-cell sequencing platform, use the Tapestri Instrument, reagents, and consumables up-front of your NGS system and then Tapestri Pipeline and Tapestri Insights software for data analysis and visualization.</div> <div class="workflow"> <div class="workflow-col"> <div class="workflow-title">Target Selection</div> <div class="workflow-copy">Choose a <span class="nowrap">pre-designed</span> or custom DNA panel</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Target-2_1.svg" alt="primer and DNA fragment alignment icon" class="worflow-icon s"> <div class="workflow-links"> <a href="/products/panels/" class="worflow-links">Pre-designed DNA Panels</a> <a href="/products/panels/custom-panels/" class="worflow-links">Custom DNA Panels with Tapestri Designer</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">SAMPLE<br>PREP</div> <div class="workflow-copy">Add a protein panel and simple cell staining protocol</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Sample.svg" alt="microtube with mixed population of cells icon" class="worflow-icon"> <div class="workflow-links"> <a href="/products/panels/totalseq-d-heme-oncology/" class="worflow-links">Protein Panels</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">LIBRARY<br>PREP</div> <div class="workflow-copy">Single workflow combines DNA and protein panels</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Prep.svg" alt="Tapestri Platform icon" class="worflow-icon"> <div class="workflow-links"> <a href="/products/platform/" class="worflow-links">Tapestri Instrument</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">SEQUENCING</div> <div class="workflow-copy">Single sequencing run for <span class="nowrap">multi-omics</span> <span class="nowrap">single-cell</span> data</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Sequence.svg" alt="next-generation sequencing platform icon" class="worflow-icon"> <div class="workflow-links"></div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">PIPELINE</div> <div class="workflow-copy">Integrated pipeline for <span class="nowrap">multi-omics</span> analysis</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-pipeline.svg" alt="Tapestri Pipeline Software icon" class="worflow-icon l"> <div class="workflow-links"> <a target="_blank" href="https://portal.missionbio.com" class="worflow-links">Tapestri Pipeline</a> </div> </div> <div class="workflow-arrow"> <img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt=""> </div> <div class="workflow-col"> <div class="workflow-title">ANALYSIS</div> <div class="workflow-copy">Powerful analysis and visualization software</div> <img src="/wp-content/themes/missionbio-v2/images/Icon-Analyze-V2.svg" alt="monitor with plots icon" class="worflow-icon l"> <div class="workflow-links"> <a target="_blank" href="https://portal.missionbio.com" class="worflow-links">Tapestri Insights</a> </div> </div> </div> </div> </div> <div id="Tapestri" class="panels-section gray"> <div id="Workflow" class="_1300-container inner-content key-benefits"> <h2 class="h2 c">Library Prep with Tapestri</h2> <p class="highlight-heading">Access high-quality data with a unique two-step microfluidic workflow</p> <div>Based on a novel two-step microfluidic workflow, the Tapestri Platform can access DNA and protein in single cells to give you true multi-omics. Each reaction in the two-step workflow is discretely optimized: isolation of DNA from the cell and oligo-conjugate antibodies in the first step, followed by targeted multiplex PCR in the second step.</div> <div class="workflow"> <div class="workflow-col"> <div class="workflow-title"> <div class="step">STEP 1</div> <div>CELL ENCAPSULATION</div> </div><img src="/wp-content/themes/missionbio-v2/images/How-1.svg" alt="" class="t-how-icon"></div> <div class="workflow-arrow"><img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt="Cells inside a channel entering oil to get encapsulated by oil"></div> <div class="workflow-col"> <div class="workflow-title"> <div>DNA + PROTEIN RELEASE</div> </div><img src="/wp-content/themes/missionbio-v2/images/How-2.svg" alt="" class="t-how-icon"></div> <div class="workflow-arrow"><img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt="Cells covered in protease and then releasing DNA and protein"></div> <div class="workflow-col"> <div class="workflow-title"> <div class="step">STEP 2</div> <div>CELL BARCODING</div> </div><img src="/wp-content/themes/missionbio-v2/images/How-3.svg" alt="" class="t-how-icon"></div> <div class="workflow-arrow"><img src="/wp-content/themes/missionbio-v2/images/Workflow-Arrow.svg" alt="Cell lysates and barcoding beads coming together to pair up"></div> <div class="workflow-col"> <div class="workflow-title"> <div>TARGET AMPLIFICATION</div> </div><img src="/wp-content/themes/missionbio-v2/images/How-4.svg" alt="DNA and protein are then amplified with primers" class="t-how-icon s"></div> </div> <div class="t-how-legend"><img src="/wp-content/themes/missionbio-v2/images/How-Legend.svg" alt="Legend for the above diagram including DNA, protein, cell barcode, gene-specific primer and protein specific primer" class="t-how-legend-icon"></div> </div> </div> <div id="Reagents" class="panels-section st"> <div class="_1300-container inner-content panels-details w c"> <h2 class="h2 c mb">Tapestri Reagents</h2> <p class="highlight-heading">Leverage Tapestri Core Reagent Kits with Targeted DNA and Protein Panels</p> <div class="benefits-cols"> <div class="benefits-card reagent"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Target-2_1.svg" alt="primer and DNA fragment alignment icon" class="benefit-icon tr"> <div class="icon-title">Targeted DNA single-cell panels</div> <div class="p-col wide"> <div class="p-bullet"> <div>Select from pre-designed panels carefully curated for a range of cancers</div> </div> <div class="p-bullet"> <div>Create a custom panel for utmost flexibility (human, mouse, or any other genome)</div> </div> <div class="p-bullet"> <div>Use our best-in-class AI-driven design engine optimized for droplet-based multiplex PCR chemistry</div> </div> </div> <a href="/products/panels/" class="more-link show">LEARN MORE</a> </div> </div> <div class="benefits-card reagent"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Sample.svg" alt="microtube with mixed population of cells icon" class="benefit-icon tr"> <div class="icon-title">Targeted protein single-cell panels</div> <div class="p-col wide"> <div class="p-bullet"> <div>Integrate oligo-tagged protein antibodies into the Tapestri workflow</div> </div> <div class="p-bullet"> <div>Explore the optimized and fully validated TotalSeq™-D Heme Oncology Cocktail and TotalSeq™-D Antibody Hashtags for multiplexing from BioLegend.</div> </div> <div class="p-bullet"> <div>Obtain concurrent measurements of DNA and proteins to uncover genotypes and phenotypes from the same cells</div> </div> </div> <a target="_blank" href="/products/panels/totalseq-d-heme-oncology/" class="more-link show">LEARN MORE</a> </div> </div> <div class="benefits-card reagent"> <div class="benefit-content"><img src="/wp-content/themes/missionbio-v2/images-2/products/panels/MBIO_Tapestri-Box.png" srcset="/wp-content/themes/missionbio-v2/images-2/products/panels/MBIO_Tapestri-Box.png 500w, /wp-content/themes/missionbio-v2/images-2/products/panels/MBIO_Tapestri-Box.png 800w" sizes="(max-width: 479px) 58vw, 250.515625px" alt="Tapestri single-cell multi-omics reagent kit image" class="benefit-icon tr _2"> <div class="icon-title">Reagent kits for DNA-only or multi-omics experiments</div> <div class="p-col wide"> <div class="p-bullet"> <div>Use with pre-titrated protein panels or custom TotalSeq-D antibodies from BioLegend</div> </div> <div class="p-bullet"> <div>Start with a suspension of single cells, or utilize our nuclei isolation protocol</div> </div> <div class="p-bullet"> <div>Compatible with any size targeted DNA panel up to 1,000 amplicons</div> </div> </div> <a href="/products/panels/" class="more-link show">LEARN MORE</a> </div> </div> </div> </div> </div> <div id="Software" class="panels-section st gray"> <div class="_1300-container inner-content panels-details c"> <h2 class="h2 c mb">Tapestri Software</h2> <p class="highlight-heading">Spend less time integrating data and more time gaining insights</p> <div class="benefits-cols"> <div class="benefits-card reagent"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-pipeline.svg" alt="Tapestri Pipeline Software icon" class="benefit-icon tr _2"> <div class="icon-title s">Tapestri Pipeline</div> <div class="p-col wide"> <div class="p-bullet"> <div>Use our streamlined bioinformatics workflow optimized for single-cell DNA and protein analysis</div> </div> <div class="p-bullet"> <div>Perform automated secondary analysis</div> </div> <div class="p-bullet"> <div>Obtain cell barcode deconvolution, read alignment, DNA variant calling, and protein expression counts</div> </div> </div> <div class="soft-cols"></div> <a target="_blank" href="https://portal.missionbio.com/" class="more-link show">LEARN MORE</a></div> </div> <div class="benefits-card reagent"> <div class="benefit-content"> <img src="/wp-content/themes/missionbio-v2/images/Icon-Analyze-V2.svg" alt="monitor with plots icon" class="benefit-icon tr _2"> <div class="icon-title s">Tapestri Insights</div> <div class="p-col wide"> <div class="p-bullet"> <div>Leverage our user-friendly and turnkey analysis solutions for meaningful insights to advance your research</div> </div> <div class="p-bullet"> <div>Perform tertiary analysis with powerful analysis and visualization tools</div> </div> <div class="p-bullet"> <div>Create UMAP plots, XY plots, violin plots, bar plots, and fish plots to uncover actionable ground-truth insights</div> </div> </div> <a target="_blank" href="https://portal.missionbio.com/" class="more-link show">LEARN MORE</a></div> </div> </div> </div> </div> <div id="Caps-Apps" class="panels-section margins"> <div class="applications-cols _1300"> <a href="/capabilities/dna-protein/" class="h-applications-col _50 st w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Capabilities</div> <div>Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.</div> <div class="more-link light">LEARN MORE</div> </div> </a> <a href="/applications/oncology/hematology/" class="h-applications-col _50 ge w-inline-block" data-ix="applications-hover"> <div class="h-application-overlay"></div> <div class="h-application-content"> <div class="h-application-title">Applications</div> <div>Conduct high-throughput single-cell DNA sequencing from thousands of cells in hematology, solid tumor, and cell and gene therapy applications.</div> <div class="more-link light">LEARN MORE</div> </div> </a> </div> </div> <div id="Resources" class="h-resources"> <div class="_1300-container inner-content"> <h3 class="h3 w">Featured Resources</h3> <div class="h-resources-grid"> <div 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href="https://missionbio.com/resources/ebooks/single-cell-sequencing-101/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn">technical note</div> <a href="https://missionbio.com/resources/technical-notes/protein-correlations-application-note/" class="h-resource-title-link"> Correlations between genomic variants and protein expression in AML patient samples </a> <br /> <a href="https://missionbio.com/resources/technical-notes/protein-correlations-application-note/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> </div> <a href="https://missionbio.com/resources/" class="more-link light show">ALL RESOURCES</a> </div> </div> <div class="cta red r"> <div class="_1300-container inner-content cta"> <h3 class="h3 w">Ready to get started?</h3> <p 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