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data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-author</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39390628" href="https://www.academia.edu/Documents/in/Medicina_Preventiva_Y_Salud_Publica"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/OsvaldoBruera","location":"/OsvaldoBruera","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/OsvaldoBruera","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Medicina Preventiva Y Salud Publica"]}" data-trace="false" data-dom-id="Pill-react-component-42e8d746-a465-4e2f-88ed-3881d799fe65"></div> <div id="Pill-react-component-42e8d746-a465-4e2f-88ed-3881d799fe65"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39390628" href="https://www.academia.edu/Documents/in/Comorbidity"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Comorbidity"]}" data-trace="false" data-dom-id="Pill-react-component-a7e92f90-0064-4c15-81d6-aca0d7d7c98f"></div> <div id="Pill-react-component-a7e92f90-0064-4c15-81d6-aca0d7d7c98f"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39390628" href="https://www.academia.edu/Documents/in/Microarray_Data_Analysis"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Microarray Data Analysis"]}" data-trace="false" data-dom-id="Pill-react-component-ba8c9195-405f-4c2e-8194-77aa9966aa79"></div> <div id="Pill-react-component-ba8c9195-405f-4c2e-8194-77aa9966aa79"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39390628" href="https://www.academia.edu/Documents/in/Biological_Activity_Of_Natural_Products"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Biological Activity Of Natural Products"]}" data-trace="false" data-dom-id="Pill-react-component-90c4889c-af63-4805-967e-cec979b5f50f"></div> <div id="Pill-react-component-90c4889c-af63-4805-967e-cec979b5f50f"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="39390628" href="https://www.academia.edu/Documents/in/Pharmacovigilance"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Pharmacovigilance"]}" data-trace="false" data-dom-id="Pill-react-component-40287434-27d3-48f1-ad78-02ebfc279987"></div> <div id="Pill-react-component-40287434-27d3-48f1-ad78-02ebfc279987"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Osvaldo Bruera</h3></div><div class="js-work-strip profile--work_container" data-work-id="113346625"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346625/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache"><img alt="Research paper thumbnail of O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346625/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache">O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache</a></div><div class="wp-workCard_item"><span>Neuromodulation</span><span>, Oct 1, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113346625"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113346625"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113346625; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113346625]").text(description); $(".js-view-count[data-work-id=113346625]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113346625; 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Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":2584,"name":"Neuromodulation","url":"https://www.academia.edu/Documents/in/Neuromodulation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":244848,"name":"Cluster Headache","url":"https://www.academia.edu/Documents/in/Cluster_Headache"},{"id":541937,"name":"Stimulation","url":"https://www.academia.edu/Documents/in/Stimulation"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":38468188,"url":"https://doi.org/10.1016/j.neurom.2022.08.149"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113346624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina"><img alt="Research paper thumbnail of Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina">Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina</a></div><div class="wp-workCard_item"><span>Revista de Neurología</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. Recently, the efficacy and safety of monoclonal antibodies that act on the calcitonin gene-related peptide pathway (MA-CGRP) has been evaluated in migraine. Several groups around the world have developed consensus guidelines about the use of monoclonal antibodies, however, in some regions is difficult to extrapolate the recommendations. AIM To provide recommendations for the use of MA-CGRP in migraine in Argentina. DEVELOPMENT A group of neurology experts from Argentina, by using the online surveys methodology as well as face to face meetings developed the intended consensus for the use of MA-CGRP in migraine in Argentina. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how, when, treatment duration and patients follow up. CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113346624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113346624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113346624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113346624]").text(description); $(".js-view-count[data-work-id=113346624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113346624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113346624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113346624, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113346624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113346624,"title":"Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina","translated_title":"","metadata":{"abstract":"INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. Recently, the efficacy and safety of monoclonal antibodies that act on the calcitonin gene-related peptide pathway (MA-CGRP) has been evaluated in migraine. Several groups around the world have developed consensus guidelines about the use of monoclonal antibodies, however, in some regions is difficult to extrapolate the recommendations. AIM To provide recommendations for the use of MA-CGRP in migraine in Argentina. DEVELOPMENT A group of neurology experts from Argentina, by using the online surveys methodology as well as face to face meetings developed the intended consensus for the use of MA-CGRP in migraine in Argentina. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how, when, treatment duration and patients follow up. CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.","publisher":"Viguera Editores SLU","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Revista de Neurología"},"translated_abstract":"INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. Recently, the efficacy and safety of monoclonal antibodies that act on the calcitonin gene-related peptide pathway (MA-CGRP) has been evaluated in migraine. Several groups around the world have developed consensus guidelines about the use of monoclonal antibodies, however, in some regions is difficult to extrapolate the recommendations. AIM To provide recommendations for the use of MA-CGRP in migraine in Argentina. DEVELOPMENT A group of neurology experts from Argentina, by using the online surveys methodology as well as face to face meetings developed the intended consensus for the use of MA-CGRP in migraine in Argentina. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how, when, treatment duration and patients follow up. CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.","internal_url":"https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina","translated_internal_url":"","created_at":"2024-01-11T10:01:04.783-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migraña_en_Argentina","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113346622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346622/Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache"><img alt="Research paper thumbnail of Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346622/Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache">Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache</a></div><div class="wp-workCard_item"><span>Cephalalgia Reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports. Conclusion: We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94200244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94200244/Burden_and_attitude_to_resistant_and_refractory_migraine_a_survey_from_the_European_Headache_Federation_with_the_endorsement_of_the_European_Migraine_and_Headache_Alliance"><img alt="Research paper thumbnail of Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance" class="work-thumbnail" src="https://attachments.academia-assets.com/96723732/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94200244/Burden_and_attitude_to_resistant_and_refractory_migraine_a_survey_from_the_European_Headache_Federation_with_the_endorsement_of_the_European_Migraine_and_Headache_Alliance">Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance</a></div><div class="wp-workCard_item"><span>The Journal of Headache and Pain</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background New treatments are currently offering new opportunities and challenges in clinical man...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache Federation (EHF) issued a Consensus document to propose criteria to approach difficult-to-treat migraine patients in a standardized way. The Consensus proposed well-defined criteria for resistant migraine (i.e., patients who do not respond to some treatment but who have residual therapeutic opportunities) and refractory migraine (i.e., patients who still have debilitating migraine despite maximal treatment efforts). The aim of this study was to better understand the perceived impact of resistant and refractory migraine and the attitude of physicians involved in migraine care toward those conditions. Methods We conducted a web-questionnair...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65197b3f63e2dc232edc20f9efb6772d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":96723732,"asset_id":94200244,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/96723732/download_file?st=MTczMjc0NDM0Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94200244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94200244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94200244; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94200244]").text(description); $(".js-view-count[data-work-id=94200244]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94200244; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94200244']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94200244, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65197b3f63e2dc232edc20f9efb6772d" } } $('.js-work-strip[data-work-id=94200244]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94200244,"title":"Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine \u0026 Headache Alliance","translated_title":"","metadata":{"abstract":"Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78259255"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78259255/SUNCT_syndrome_responding_absolutely_to_steroids_in_two_cases_with_different_etiologies"><img alt="Research paper thumbnail of SUNCT syndrome responding absolutely to steroids in two cases with different etiologies" class="work-thumbnail" src="https://attachments.academia-assets.com/85378040/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78259255/SUNCT_syndrome_responding_absolutely_to_steroids_in_two_cases_with_different_etiologies">SUNCT syndrome responding absolutely to steroids in two cases with different etiologies</a></div><div class="wp-workCard_item"><span>The Journal of Headache and Pain</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="28c5c968397f7e519960ab043e77f633" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85378040,"asset_id":78259255,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85378040/download_file?st=MTczMjc0NDM0Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78259255"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78259255"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78259255; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78259246"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78259246/Prophylatic_treatment_of_migraine_and_migraine_clinical_variants_with_topiramate_an_update"><img alt="Research paper thumbnail of Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update" class="work-thumbnail" src="https://attachments.academia-assets.com/85368467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78259246/Prophylatic_treatment_of_migraine_and_migraine_clinical_variants_with_topiramate_an_update">Prophylatic treatment of migraine and migraine clinical variants with topiramate: an update</a></div><div class="wp-workCard_item"><span>Therapeutics and Clinical Risk Management</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="98a08e6e9e9e968faabcad7adfbbb8d2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85368467,"asset_id":78259246,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85368467/download_file?st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78259246"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78259246"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78259246; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65906377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something"><img alt="Research paper thumbnail of High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something">High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. Data from 111 migraine patients was included for an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65906377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65906377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65906377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65906377]").text(description); $(".js-view-count[data-work-id=65906377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65906377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65906377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65906377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65906377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65906377,"title":"High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?","translated_title":"","metadata":{"abstract":"Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. 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Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. Data from 111 migraine patients was included for an...","internal_url":"https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something","translated_internal_url":"","created_at":"2021-12-24T20:43:56.936-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65906376"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65906376/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking"><img alt="Research paper thumbnail of Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65906376/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking">Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65906376"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65906376"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65906376; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65906376]").text(description); $(".js-view-count[data-work-id=65906376]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65906376; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65906376']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65906376, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65906376]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65906376,"title":"Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking","translated_title":"","metadata":{"abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. 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University Center for Headache and Adaptive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PATTERN. A cooperative international long-term study. University Center for Headache and Adaptive Disorders, Dept. of Neurology, Pavia, Parma and Milano (Italy&quot;), Trondheim and Oslo (Norway**), Sao Paulo (Brazil***) and Buenos Aires (Argentina****) Chairmen: Giuseppe Nappi*, Ottar Sjaastad**, Edgard Raffaelli Jr***, Jorge A. Leston**** Co-workers: GL Miciell-*, G. C. Manzoni*, G. Bussone*, G. Helde**, A.S.E. Dacua***, O.J. Martins***, M. Figuerola****, 0. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56810102"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56810102/_288_An_unusual_case_of_low_back_pain"><img alt="Research paper thumbnail of (288) An unusual case of low back pain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56810102/_288_An_unusual_case_of_low_back_pain">(288) An unusual case of low back pain</a></div><div class="wp-workCard_item"><span>The Journal of Pain</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered pelvic bone fracture, inferior cava vein lesion with local thrombosis and transitory paraplegy. He complained of severe low back pain in the vertebral bones, right paraspinal muscles, right groin, right sciatica, besides, epigastric pain. CT scans, MRI&amp;#39;s images, and ultrasound studies showed the inferior cava vein colapsed by a big hematic collection There was no strong evidence of red flags for back pain. In 2004, the patient suffered a deep vein trombosis and was prescribed anticoagulant drugs for a year. He took tramadol (up to 300 mg/day), clonazepam (up to 6 mg/day), oxycodone (low dose: difficult to tolerate, ineffective), methadone (low dose: difficult to tolerate, ineffective), NSAID&amp;#39;s (Diclofenac, Meloxicam: ineffective), Pregabalin (150 mg/day: difficult to tolerate, ineffective), acupuncture (ineffective), fentanyl transdermal patches (25 mcg/hour: difficult to tolerate, ineffective), duloxetine (30 mg: difficult to tolerate, ineffective), ), TENS (ineffective), facet joint and radicular anesthesic blockade (ineffective). The pain (deep and drilling with brief electrical shocks) was described as severe (scale intensity: 8/10). Before using an infusion pump or a neurostimulator method we recommended the patient to see a vascular surgeon in order to withdraw the thrombotic mass through surgery in an attempt to ease the pain. The patient underwent surgery in October 2007. We were surprised by the following surgical findings: there were no thrombus, the inferior cava vein was not compromised, and there was an expansive tumoral mass compressing the structures nearby. The tumoral mass was analyzed at a pathology laboratory and the results suggest either a Schwannoma or neurilemoma. It is still under evaluation We hope that these findings provide the necessary information in order to reach the most adequate treatment for this patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56810102"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56810102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56810102; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56810102]").text(description); $(".js-view-count[data-work-id=56810102]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56810102; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56810102']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 56810102, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=56810102]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56810102,"title":"(288) An unusual case of low back pain","translated_title":"","metadata":{"abstract":"ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered pelvic bone fracture, inferior cava vein lesion with local thrombosis and transitory paraplegy. 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He took tramadol (up to 300 mg/day), clonazepam (up to 6 mg/day), oxycodone (low dose: difficult to tolerate, ineffective), methadone (low dose: difficult to tolerate, ineffective), NSAID\u0026amp;#39;s (Diclofenac, Meloxicam: ineffective), Pregabalin (150 mg/day: difficult to tolerate, ineffective), acupuncture (ineffective), fentanyl transdermal patches (25 mcg/hour: difficult to tolerate, ineffective), duloxetine (30 mg: difficult to tolerate, ineffective), ), TENS (ineffective), facet joint and radicular anesthesic blockade (ineffective). The pain (deep and drilling with brief electrical shocks) was described as severe (scale intensity: 8/10). Before using an infusion pump or a neurostimulator method we recommended the patient to see a vascular surgeon in order to withdraw the thrombotic mass through surgery in an attempt to ease the pain. The patient underwent surgery in October 2007. We were surprised by the following surgical findings: there were no thrombus, the inferior cava vein was not compromised, and there was an expansive tumoral mass compressing the structures nearby. The tumoral mass was analyzed at a pathology laboratory and the results suggest either a Schwannoma or neurilemoma. It is still under evaluation We hope that these findings provide the necessary information in order to reach the most adequate treatment for this patient.","internal_url":"https://www.academia.edu/56810102/_288_An_unusual_case_of_low_back_pain","translated_internal_url":"","created_at":"2021-10-09T09:49:34.395-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_288_An_unusual_case_of_low_back_pain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":2898,"name":"Pain","url":"https://www.academia.edu/Documents/in/Pain"},{"id":40760,"name":"Low back pain","url":"https://www.academia.edu/Documents/in/Low_back_pain"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); 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Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6dc2369d63205a5412b817e0e432f495" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71916675,"asset_id":56618512,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71916675/download_file?st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56618512"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56618512"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56618512; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56618512]").text(description); $(".js-view-count[data-work-id=56618512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56618512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56618512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 56618512, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6dc2369d63205a5412b817e0e432f495" } } $('.js-work-strip[data-work-id=56618512]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56618512,"title":"Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking","translated_title":"","metadata":{"abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4176915" id="papers"><div class="js-work-strip profile--work_container" data-work-id="113346625"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346625/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache"><img alt="Research paper thumbnail of O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346625/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache">O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache</a></div><div class="wp-workCard_item"><span>Neuromodulation</span><span>, Oct 1, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113346625"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113346625"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113346625; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113346624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina"><img alt="Research paper thumbnail of Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina">Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina</a></div><div class="wp-workCard_item"><span>Revista de Neurología</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. Recently, the efficacy and safety of monoclonal antibodies that act on the calcitonin gene-related peptide pathway (MA-CGRP) has been evaluated in migraine. Several groups around the world have developed consensus guidelines about the use of monoclonal antibodies, however, in some regions is difficult to extrapolate the recommendations. AIM To provide recommendations for the use of MA-CGRP in migraine in Argentina. DEVELOPMENT A group of neurology experts from Argentina, by using the online surveys methodology as well as face to face meetings developed the intended consensus for the use of MA-CGRP in migraine in Argentina. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how, when, treatment duration and patients follow up. CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113346624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113346624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113346624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113346624]").text(description); $(".js-view-count[data-work-id=113346624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113346624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113346624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113346624, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113346624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113346624,"title":"Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina","translated_title":"","metadata":{"abstract":"INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. 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CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.","publisher":"Viguera Editores SLU","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Revista de Neurología"},"translated_abstract":"INTRODUCTION Migraine is a very prevalent disorder that is estimated to affect about 15% of adult subjects. Recently, the efficacy and safety of monoclonal antibodies that act on the calcitonin gene-related peptide pathway (MA-CGRP) has been evaluated in migraine. Several groups around the world have developed consensus guidelines about the use of monoclonal antibodies, however, in some regions is difficult to extrapolate the recommendations. AIM To provide recommendations for the use of MA-CGRP in migraine in Argentina. DEVELOPMENT A group of neurology experts from Argentina, by using the online surveys methodology as well as face to face meetings developed the intended consensus for the use of MA-CGRP in migraine in Argentina. Recommendations were established based on published evidence and the expert opinion. Recommendations focused on how, when, treatment duration and patients follow up. CONCLUSION The recommendations of this consensus guidelines attempt to optimize the use of MA-CGRP in migraine in Argentina.","internal_url":"https://www.academia.edu/113346624/Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migra%C3%B1a_en_Argentina","translated_internal_url":"","created_at":"2024-01-11T10:01:04.783-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Consenso_sobre_el_uso_de_anticuerpos_monoclonales_en_la_migraña_en_Argentina","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113346622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113346622/Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache"><img alt="Research paper thumbnail of Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113346622/Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache">Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache</a></div><div class="wp-workCard_item"><span>Cephalalgia Reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports. Conclusion: We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. We propose this class of drugs, as a therapeutic option for NDPH.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113346622"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113346622"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113346622; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113346622]").text(description); $(".js-view-count[data-work-id=113346622]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113346622; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113346622']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113346622, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113346622]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113346622,"title":"Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache","translated_title":"","metadata":{"abstract":"Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports. Conclusion: We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. We propose this class of drugs, as a therapeutic option for NDPH.","publisher":"SAGE Publications","publication_name":"Cephalalgia Reports"},"translated_abstract":"Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports. Conclusion: We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. We propose this class of drugs, as a therapeutic option for NDPH.","internal_url":"https://www.academia.edu/113346622/Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache","translated_internal_url":"","created_at":"2024-01-11T10:00:48.251-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Case_report_Monoclonal_antibodies_as_an_alternative_treatment_for_new_daily_persistent_headache","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[],"urls":[{"id":38468186,"url":"http://journals.sagepub.com/doi/pdf/10.1177/25158163231195769"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94200248"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94200248/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache"><img alt="Research paper thumbnail of O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94200248/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache">O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache</a></div><div class="wp-workCard_item"><span>Neuromodulation: Technology at the Neural Interface</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94200248"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94200248"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94200248; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94200248]").text(description); $(".js-view-count[data-work-id=94200248]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94200248; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94200248']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94200248, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=94200248]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94200248,"title":"O111 / #562 Long -Term Effectiveness of Combined Unilateral Sphenopalatine and Occipital Nerve Stimulation in Seven Patients with Refractory Cluster Headache","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Neuromodulation: Technology at the Neural Interface"},"translated_abstract":null,"internal_url":"https://www.academia.edu/94200248/O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache","translated_internal_url":"","created_at":"2023-01-02T18:23:14.385-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"O111_562_Long_Term_Effectiveness_of_Combined_Unilateral_Sphenopalatine_and_Occipital_Nerve_Stimulation_in_Seven_Patients_with_Refractory_Cluster_Headache","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":2584,"name":"Neuromodulation","url":"https://www.academia.edu/Documents/in/Neuromodulation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":244848,"name":"Cluster Headache","url":"https://www.academia.edu/Documents/in/Cluster_Headache"},{"id":541937,"name":"Stimulation","url":"https://www.academia.edu/Documents/in/Stimulation"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":27678559,"url":"https://api.elsevier.com/content/article/PII:S1094715922009242?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="94200244"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/94200244/Burden_and_attitude_to_resistant_and_refractory_migraine_a_survey_from_the_European_Headache_Federation_with_the_endorsement_of_the_European_Migraine_and_Headache_Alliance"><img alt="Research paper thumbnail of Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance" class="work-thumbnail" src="https://attachments.academia-assets.com/96723732/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/94200244/Burden_and_attitude_to_resistant_and_refractory_migraine_a_survey_from_the_European_Headache_Federation_with_the_endorsement_of_the_European_Migraine_and_Headache_Alliance">Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance</a></div><div class="wp-workCard_item"><span>The Journal of Headache and Pain</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background New treatments are currently offering new opportunities and challenges in clinical man...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache Federation (EHF) issued a Consensus document to propose criteria to approach difficult-to-treat migraine patients in a standardized way. The Consensus proposed well-defined criteria for resistant migraine (i.e., patients who do not respond to some treatment but who have residual therapeutic opportunities) and refractory migraine (i.e., patients who still have debilitating migraine despite maximal treatment efforts). The aim of this study was to better understand the perceived impact of resistant and refractory migraine and the attitude of physicians involved in migraine care toward those conditions. Methods We conducted a web-questionnair...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65197b3f63e2dc232edc20f9efb6772d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":96723732,"asset_id":94200244,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/96723732/download_file?st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDM0Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="94200244"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="94200244"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 94200244; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=94200244]").text(description); $(".js-view-count[data-work-id=94200244]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 94200244; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='94200244']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 94200244, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65197b3f63e2dc232edc20f9efb6772d" } } $('.js-work-strip[data-work-id=94200244]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":94200244,"title":"Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine \u0026 Headache Alliance","translated_title":"","metadata":{"abstract":"Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65906377"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something"><img alt="Research paper thumbnail of High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something">High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. Data from 111 migraine patients was included for an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65906377"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65906377"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65906377; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65906377]").text(description); $(".js-view-count[data-work-id=65906377]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65906377; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65906377']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65906377, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65906377]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65906377,"title":"High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?","translated_title":"","metadata":{"abstract":"Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. Data from 111 migraine patients was included for an...","publisher":"Neurological Sciences","publication_date":{"day":null,"month":null,"year":2021,"errors":{}}},"translated_abstract":"Roughly three percent of episodic migraine patients evolve into the most burdensome chronic form of this condition every year. While some of the determinants behind this transformation are well established, others are still ill defined. Hypothyroidism is a prevalent endocrinological disorder that can both produce a secondary headache or aggravate a pre-existing primary headache disorder such as migraine. We aimed to re-assess the association between hypothyroidism and chronic migraine controlling for factors such as hormone replacement treatment status and bodyweight. We retrospectively analyzed the medical records of episodic and chronic migraine patients who consecutively consulted our headache clinic in order to determine the prevalence of adequately treated hypothyroidism in each group. Only patients receiving a stable dose regimen were included. The body mass index and other possibly confounding covariates were also collected. Data from 111 migraine patients was included for an...","internal_url":"https://www.academia.edu/65906377/High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something","translated_internal_url":"","created_at":"2021-12-24T20:43:56.936-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"High_rates_of_treated_hypothyroidism_among_chronic_migraine_patients_consulting_a_specialized_headache_clinic_are_we_missing_something","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65906376"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65906376/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking"><img alt="Research paper thumbnail of Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65906376/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking">Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65906376"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65906376"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65906376; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65906376]").text(description); $(".js-view-count[data-work-id=65906376]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65906376; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65906376']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65906376, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65906376]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65906376,"title":"Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking","translated_title":"","metadata":{"abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...","publisher":"Functional neurology","publication_date":{"day":null,"month":null,"year":2008,"errors":{}}},"translated_abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...","internal_url":"https://www.academia.edu/65906376/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking","translated_internal_url":"","created_at":"2021-12-24T20:43:56.831-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":39390628,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":39390628,"first_name":"Osvaldo","middle_initials":null,"last_name":"Bruera","page_name":"OsvaldoBruera","domain_name":"independent","created_at":"2015-11-29T07:36:15.359-08:00","display_name":"Osvaldo Bruera","url":"https://independent.academia.edu/OsvaldoBruera"},"attachments":[],"research_interests":[{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"},{"id":244848,"name":"Cluster Headache","url":"https://www.academia.edu/Documents/in/Cluster_Headache"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":294768,"name":"Wakefulness","url":"https://www.academia.edu/Documents/in/Wakefulness"},{"id":327959,"name":"Functional Neurology","url":"https://www.academia.edu/Documents/in/Functional_Neurology"},{"id":612548,"name":"Tension-Type Headache","url":"https://www.academia.edu/Documents/in/Tension-Type_Headache"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values"},{"id":1772810,"name":"Sleep Stages","url":"https://www.academia.edu/Documents/in/Sleep_Stages"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies"},{"id":3979531,"name":"Migraine disorders","url":"https://www.academia.edu/Documents/in/Migraine_disorders"}],"urls":[{"id":15668331,"url":"https://www.functionalneurology.com/common/php/portiere.php?ID=c6b0c016542bbcbbd8a207f67fc6c08e"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65906375"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65906375/Weather_Interference_on_Cluster_Headache_Temporal_Pattern_A_Cooperative_International_Long_Term_Study"><img alt="Research paper thumbnail of Weather Interference on Cluster Headache Temporal Pattern. A Cooperative International Long-Term Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65906375/Weather_Interference_on_Cluster_Headache_Temporal_Pattern_A_Cooperative_International_Long_Term_Study">Weather Interference on Cluster Headache Temporal Pattern. A Cooperative International Long-Term Study</a></div><div class="wp-workCard_item"><span>Cephalalgia</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">PATTERN. A cooperative international long-term study. University Center for Headache and Adaptive...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PATTERN. A cooperative international long-term study. University Center for Headache and Adaptive Disorders, Dept. of Neurology, Pavia, Parma and Milano (Italy&quot;), Trondheim and Oslo (Norway**), Sao Paulo (Brazil***) and Buenos Aires (Argentina****) Chairmen: Giuseppe Nappi*, Ottar Sjaastad**, Edgard Raffaelli Jr***, Jorge A. Leston**** Co-workers: GL Miciell-*, G. C. Manzoni*, G. Bussone*, G. Helde**, A.S.E. Dacua***, O.J. Martins***, M. Figuerola****, 0. Bruera****</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65906375"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65906375"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65906375; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65906375]").text(description); $(".js-view-count[data-work-id=65906375]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65906375; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65906375']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 65906375, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65906375]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65906375,"title":"Weather Interference on Cluster Headache Temporal Pattern. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56810102"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56810102/_288_An_unusual_case_of_low_back_pain"><img alt="Research paper thumbnail of (288) An unusual case of low back pain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56810102/_288_An_unusual_case_of_low_back_pain">(288) An unusual case of low back pain</a></div><div class="wp-workCard_item"><span>The Journal of Pain</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered pelvic bone fracture, inferior cava vein lesion with local thrombosis and transitory paraplegy. He complained of severe low back pain in the vertebral bones, right paraspinal muscles, right groin, right sciatica, besides, epigastric pain. CT scans, MRI&amp;#39;s images, and ultrasound studies showed the inferior cava vein colapsed by a big hematic collection There was no strong evidence of red flags for back pain. In 2004, the patient suffered a deep vein trombosis and was prescribed anticoagulant drugs for a year. He took tramadol (up to 300 mg/day), clonazepam (up to 6 mg/day), oxycodone (low dose: difficult to tolerate, ineffective), methadone (low dose: difficult to tolerate, ineffective), NSAID&amp;#39;s (Diclofenac, Meloxicam: ineffective), Pregabalin (150 mg/day: difficult to tolerate, ineffective), acupuncture (ineffective), fentanyl transdermal patches (25 mcg/hour: difficult to tolerate, ineffective), duloxetine (30 mg: difficult to tolerate, ineffective), ), TENS (ineffective), facet joint and radicular anesthesic blockade (ineffective). The pain (deep and drilling with brief electrical shocks) was described as severe (scale intensity: 8/10). Before using an infusion pump or a neurostimulator method we recommended the patient to see a vascular surgeon in order to withdraw the thrombotic mass through surgery in an attempt to ease the pain. The patient underwent surgery in October 2007. We were surprised by the following surgical findings: there were no thrombus, the inferior cava vein was not compromised, and there was an expansive tumoral mass compressing the structures nearby. The tumoral mass was analyzed at a pathology laboratory and the results suggest either a Schwannoma or neurilemoma. It is still under evaluation We hope that these findings provide the necessary information in order to reach the most adequate treatment for this patient.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56810102"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56810102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56810102; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56810102]").text(description); $(".js-view-count[data-work-id=56810102]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56810102; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56810102']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 56810102, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=56810102]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56810102,"title":"(288) An unusual case of low back pain","translated_title":"","metadata":{"abstract":"ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered pelvic bone fracture, inferior cava vein lesion with local thrombosis and transitory paraplegy. He complained of severe low back pain in the vertebral bones, right paraspinal muscles, right groin, right sciatica, besides, epigastric pain. CT scans, MRI\u0026amp;#39;s images, and ultrasound studies showed the inferior cava vein colapsed by a big hematic collection There was no strong evidence of red flags for back pain. In 2004, the patient suffered a deep vein trombosis and was prescribed anticoagulant drugs for a year. He took tramadol (up to 300 mg/day), clonazepam (up to 6 mg/day), oxycodone (low dose: difficult to tolerate, ineffective), methadone (low dose: difficult to tolerate, ineffective), NSAID\u0026amp;#39;s (Diclofenac, Meloxicam: ineffective), Pregabalin (150 mg/day: difficult to tolerate, ineffective), acupuncture (ineffective), fentanyl transdermal patches (25 mcg/hour: difficult to tolerate, ineffective), duloxetine (30 mg: difficult to tolerate, ineffective), ), TENS (ineffective), facet joint and radicular anesthesic blockade (ineffective). The pain (deep and drilling with brief electrical shocks) was described as severe (scale intensity: 8/10). Before using an infusion pump or a neurostimulator method we recommended the patient to see a vascular surgeon in order to withdraw the thrombotic mass through surgery in an attempt to ease the pain. The patient underwent surgery in October 2007. We were surprised by the following surgical findings: there were no thrombus, the inferior cava vein was not compromised, and there was an expansive tumoral mass compressing the structures nearby. The tumoral mass was analyzed at a pathology laboratory and the results suggest either a Schwannoma or neurilemoma. It is still under evaluation We hope that these findings provide the necessary information in order to reach the most adequate treatment for this patient.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"The Journal of Pain"},"translated_abstract":"ABSTRACT A 35 year old male patient with a low back injury since 2003, who at the time suffered pelvic bone fracture, inferior cava vein lesion with local thrombosis and transitory paraplegy. He complained of severe low back pain in the vertebral bones, right paraspinal muscles, right groin, right sciatica, besides, epigastric pain. CT scans, MRI\u0026amp;#39;s images, and ultrasound studies showed the inferior cava vein colapsed by a big hematic collection There was no strong evidence of red flags for back pain. In 2004, the patient suffered a deep vein trombosis and was prescribed anticoagulant drugs for a year. He took tramadol (up to 300 mg/day), clonazepam (up to 6 mg/day), oxycodone (low dose: difficult to tolerate, ineffective), methadone (low dose: difficult to tolerate, ineffective), NSAID\u0026amp;#39;s (Diclofenac, Meloxicam: ineffective), Pregabalin (150 mg/day: difficult to tolerate, ineffective), acupuncture (ineffective), fentanyl transdermal patches (25 mcg/hour: difficult to tolerate, ineffective), duloxetine (30 mg: difficult to tolerate, ineffective), ), TENS (ineffective), facet joint and radicular anesthesic blockade (ineffective). The pain (deep and drilling with brief electrical shocks) was described as severe (scale intensity: 8/10). Before using an infusion pump or a neurostimulator method we recommended the patient to see a vascular surgeon in order to withdraw the thrombotic mass through surgery in an attempt to ease the pain. The patient underwent surgery in October 2007. We were surprised by the following surgical findings: there were no thrombus, the inferior cava vein was not compromised, and there was an expansive tumoral mass compressing the structures nearby. The tumoral mass was analyzed at a pathology laboratory and the results suggest either a Schwannoma or neurilemoma. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56810039"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56810039/1_21_11_Cervical_blocks_in_chronic_daily_headache"><img alt="Research paper thumbnail of 1-21-11 Cervical blocks in chronic daily headache" class="work-thumbnail" src="https://attachments.academia-assets.com/72013396/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56810039/1_21_11_Cervical_blocks_in_chronic_daily_headache">1-21-11 Cervical blocks in chronic daily headache</a></div><div class="wp-workCard_item"><span>Journal of the Neurological Sciences</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e6cc8298920bcab921d47633a2ba5c5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72013396,"asset_id":56810039,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72013396/download_file?st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56810039"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56810039"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56810039; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="56618512"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/56618512/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking"><img alt="Research paper thumbnail of Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking" class="work-thumbnail" src="https://attachments.academia-assets.com/71916675/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/56618512/Plasma_melatonin_pattern_in_chronic_and_episodic_headaches_evaluation_during_sleep_and_waking">Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking</a></div><div class="wp-workCard_item"><span>Functional neurology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6dc2369d63205a5412b817e0e432f495" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71916675,"asset_id":56618512,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71916675/download_file?st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDM0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="56618512"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="56618512"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 56618512; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=56618512]").text(description); $(".js-view-count[data-work-id=56618512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 56618512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='56618512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 56618512, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6dc2369d63205a5412b817e0e432f495" } } $('.js-work-strip[data-work-id=56618512]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":56618512,"title":"Plasma melatonin pattern in chronic and episodic headaches: evaluation during sleep and waking","translated_title":"","metadata":{"abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. A trend to normalization of the curve during the remission period was observed. On the basis of these different melatonin secretion patterns, it might be hypoth...","publication_name":"Functional neurology"},"translated_abstract":"To look for a relationship between pineal function in chronic migraine (CM), cluster headache (CH) (during active and remission periods), chronic tension-type headache (CTTH) patients and controls during NREM sleep, REM sleep and waking, we performed serial sampling of plasma melatonin in the different sleep stages during the first half of the night, in order to avoid chronobiological interferences. Plasma melatonin levels did not show a normal curve either in the CTTH or in the CM patients and no significant differences between these groups were found in any of the sleep stages studied. Plasma melatonin values of CH patients during the cluster period showed an abnormal pattern. The curve showed a pathological lack of peaks during the active period, melatonin levels remaining within normal daytime range throughout the study. 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