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window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":59135224,"created_at":"2021-10-20T10:37:33.259-07:00","from_world_paper_id":180582947,"updated_at":"2024-11-24T02:33:35.561-08:00","_data":{"publisher":"Springer Nature","grobid_abstract":"Background: Painters are exposed to an extensive variety of harmful substances like aromatic hydrocarbons used as solvents and paint removers, some of which have shown clastogenic activity. These substances constitute a complex mixture of chemicals which contain well-known genotoxicants, such as Benzene, Toluene and Xylene. Thus, chronic occupational exposure to such substances may be considered to possess genotoxic risk. In Colombia the information available around the genotoxic damage (Chromosomal and DNA damage) in car paint shop workers is limited and the knowledge of this damage could contribute not only to a better understanding of the carcinogenic effect of this kind of substances but also could be used as biomarkers of occupational exposure to genotoxic agents. Results: In this study, the genotoxic effect of aromatic hydrocarbons was assessed in peripheral blood lymphocytes of 24 workers occupationally exposed and 24 unexposed donors, by using Cytogenetic analysis and comet assay. A high frequency of Chromosomal alterations was found in the exposed group in comparison with those observed in the unexposed group. Among the total of CAs observed in the exposed group, fragilities were most frequently found (100 %), followed by chromosomal breaks (58 %), structural (41.2 %) and numerical chromosomal alterations (21 %). Numerical chromosomal alterations, fragilities and chromosomal breaks showed significant differences between exposed and unexposed groups. Among the fragilities, fra(9)(q12) was the most frequently observed. DNA damage index was also significantly higher in the exposed group compared to the unexposed group (p \u003c 0.000). Conclusions: Our results revealed that occupational exposure to aromatic hydrocarbons is significantly associated with Chromosomal and DNA damage in car paint shops workers and are also indicative of high chromosomal instability. The high frequency of both Chromosomal Alterations and DNA Damage Index observed in this study indicates an urgent need of intervention not only to prevent the increased risk of developing cancer but also to the application of strict health control and motivation to the use of appropriate protecting devices during work.","publication_date":"2016,,","publication_name":"Molecular Cytogenetics","grobid_abstract_attachment_id":"73215195"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"High chromosomal instability in workers occupationally exposed to solvents and paint removers","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [201407174]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":73215195,"attachmentType":"pdf"}"><img alt="First page of “High chromosomal instability in workers occupationally exposed to solvents and paint removers”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/73215195/mini_magick20211020-10552-yn0op.png?1634751565" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">High chromosomal instability in workers occupationally exposed to solvents and paint removers</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="201407174" href="https://independent.academia.edu/MilenaRond%C3%B3nLagos"><img alt="Profile image of Milena Rondón Lagos" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/201407174/62737937/51033790/s65_milena.rond_n_lagos.png" />Milena Rondón Lagos</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2016, Molecular Cytogenetics</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">9 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 59135224; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Background: Painters are exposed to an extensive variety of harmful substances like aromatic hydrocarbons used as solvents and paint removers, some of which have shown clastogenic activity. These substances constitute a complex mixture of chemicals which contain well-known genotoxicants, such as Benzene, Toluene and Xylene. Thus, chronic occupational exposure to such substances may be considered to possess genotoxic risk. In Colombia the information available around the genotoxic damage (Chromosomal and DNA damage) in car paint shop workers is limited and the knowledge of this damage could contribute not only to a better understanding of the carcinogenic effect of this kind of substances but also could be used as biomarkers of occupational exposure to genotoxic agents. Results: In this study, the genotoxic effect of aromatic hydrocarbons was assessed in peripheral blood lymphocytes of 24 workers occupationally exposed and 24 unexposed donors, by using Cytogenetic analysis and comet assay. A high frequency of Chromosomal alterations was found in the exposed group in comparison with those observed in the unexposed group. Among the total of CAs observed in the exposed group, fragilities were most frequently found (100 %), followed by chromosomal breaks (58 %), structural (41.2 %) and numerical chromosomal alterations (21 %). Numerical chromosomal alterations, fragilities and chromosomal breaks showed significant differences between exposed and unexposed groups. Among the fragilities, fra(9)(q12) was the most frequently observed. DNA damage index was also significantly higher in the exposed group compared to the unexposed group (p < 0.000). Conclusions: Our results revealed that occupational exposure to aromatic hydrocarbons is significantly associated with Chromosomal and DNA damage in car paint shops workers and are also indicative of high chromosomal instability. The high frequency of both Chromosomal Alterations and DNA Damage Index observed in this study indicates an urgent need of intervention not only to prevent the increased risk of developing cancer but also to the application of strict health control and motivation to the use of appropriate protecting devices during work.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":73215195,"attachmentType":"pdf","workUrl":"https://www.academia.edu/59135224/High_chromosomal_instability_in_workers_occupationally_exposed_to_solvents_and_paint_removers"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":73215195,"attachmentType":"pdf","workUrl":"https://www.academia.edu/59135224/High_chromosomal_instability_in_workers_occupationally_exposed_to_solvents_and_paint_removers"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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An increased risk of cancer has also been reported in occupations with heavy exposure to traffic-related pollution. The aim of this study was to assess the cytogenetic effects of urban air pollution by analyzing the chromosomal aberration (CA) frequencies in lymphocytes and to estimate the polycyclic aromatic hydrocarbons (PAHs) exposure by measuring urinary 1hydroxypyrene (1-OHP) levels. A total of 15 traffic policemen and 17 taxi drivers working in the city of Ankara were the exposed groups and 23 healthy men working in the office departments were the control group. The overall mean AE S:D: values of 1-OHP excretions of traffic policemen, taxi drivers and control subjects were 0:59 AE 0:40 lmol=mol creatinine, 0:32 AE 0:25 lmol=mol creatinine and 0:57 AE 0:36 lmol=mol creatinine, respectively. Urinary 1-OHP levels of nonsmoking policemen were significantly greater than those of nonsmoking control subjects ðp < 0:05Þ. The overall mean AE S:D: values for CA frequencies (%) from policemen, taxi drivers and control group were 1:29 AE 1:59, 1:81 AE 1:79, and 0:26 AE 0:73, respectively. There was a significantly greater frequency of CAs in exposed groups relative to the matched control population ðp < 0:05; p < 0:01Þ. Age, sex and smoking habits have not influenced the cytogenetic end-point in this study. Our results demonstrate that occupational exposure to urban air pollutants leads to a significant induction of cytogenetic damage in peripheral lymphocytes of traffic policemen and taxi drivers. Ó</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals","attachmentId":44159546,"attachmentType":"pdf","work_url":"https://www.academia.edu/14421215/Chromosomal_damage_in_peripheral_blood_lymphocytes_from_nurses_occupationally_exposed_to_chemicals","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14421215/Chromosomal_damage_in_peripheral_blood_lymphocytes_from_nurses_occupationally_exposed_to_chemicals"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="5078067" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5078067/Evaluation_of_genotoxicity_in_a_group_of_workers_from_a_petroleum_refinery_aromatics_plant">Evaluation of genotoxicity in a group of workers from a petroleum refinery aromatics plant</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6794574" href="https://independent.academia.edu/SusanaSilva8">Susana Silva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Mutation Research-genetic Toxicology and Environmental Mutagenesis, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Petroleum refinery workers are potentially exposed to a wide range of petroleum-derived hydrocarbons and chemical substances used in the manufacturing of petroleum derivatives. Benzene, toluene and xylene (BTX) are produced by distillation in the aromatics units and used as raw materials for petrol and petrochemical products. The aim of this study was to evaluate the genotoxic effects of occupational exposure to BTX in a petroleum refinery in the North of Portugal. The exposed group consisted of 48 workers from the aromatics plant and the control group consisted of 30 persons matched for various confounding factors.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of genotoxicity in a group of workers from a petroleum refinery aromatics plant","attachmentId":49459164,"attachmentType":"pdf","work_url":"https://www.academia.edu/5078067/Evaluation_of_genotoxicity_in_a_group_of_workers_from_a_petroleum_refinery_aromatics_plant","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5078067/Evaluation_of_genotoxicity_in_a_group_of_workers_from_a_petroleum_refinery_aromatics_plant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="62819354" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene">Cytogenetic changes in subjects occupationally exposed to benzene</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33146506" href="https://independent.academia.edu/KarmelaSentija">Karmela Sentija</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chemosphere, 2000</p><p class="ds-related-work--abstract ds2-5-body-sm">Humans are exposed to benzene from various occupational and environmental sources. The genotoxic eects of benzene were assessed in peripheral blood lymphocytes of 36 workers employed in the shoe industry for a period extending from seven months to over 30 years. Chromosomal aberrations and sister chromatide exchanges were used as indicators of genotoxic eects. The incidence of dicentric chromosomes in the exposed group was signi®cantly higher than in the control group (P < 0.05). No signi®cant increase was detected between the working period in the exposed group and chromosomal aberrations. Sister chromatide exchange (SCE) frequency was not signi®cantly increased in the exposed group.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytogenetic changes in subjects occupationally exposed to benzene","attachmentId":75465370,"attachmentType":"pdf","work_url":"https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62819354/Cytogenetic_changes_in_subjects_occupationally_exposed_to_benzene"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="120586102" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/120586102/Estimation_of_cytogenetic_risk_among_coke_oven_workers_exposed_to_polycyclic_aromatic_hydrocarbons">Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="303263162" href="https://independent.academia.edu/MohanaDevi19">Mohana Devi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Biochimica Polonica, 2013</p><p class="ds-related-work--abstract ds2-5-body-sm">Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group I</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons","attachmentId":115687682,"attachmentType":"pdf","work_url":"https://www.academia.edu/120586102/Estimation_of_cytogenetic_risk_among_coke_oven_workers_exposed_to_polycyclic_aromatic_hydrocarbons","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/120586102/Estimation_of_cytogenetic_risk_among_coke_oven_workers_exposed_to_polycyclic_aromatic_hydrocarbons"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="18191099" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18191099/Chromosomal_Aberrations_in_Males_Occupationally_Exposed_to_Chemical_Pollutants_in_the_Gaza_Strip_Palestine">Chromosomal Aberrations in Males Occupationally Exposed to Chemical Pollutants in the Gaza Strip-Palestine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="421518" href="https://iugaza-ps.academia.edu/FadelSharif">Fadel A Sharif</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39541345" href="https://uni-saarland.academia.edu/MohammedLaqqan">Mohammed Laqqan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">iugaza.edu.ps</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective: This study was conducted to evaluate the frequency of chromosomal aberrations in peripheral blood lymphocytes from Palestinian males exposed to various chemical pollutants during their daily work.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Chromosomal Aberrations in Males Occupationally Exposed to Chemical Pollutants in the Gaza Strip-Palestine","attachmentId":39924606,"attachmentType":"pdf","work_url":"https://www.academia.edu/18191099/Chromosomal_Aberrations_in_Males_Occupationally_Exposed_to_Chemical_Pollutants_in_the_Gaza_Strip_Palestine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18191099/Chromosomal_Aberrations_in_Males_Occupationally_Exposed_to_Chemical_Pollutants_in_the_Gaza_Strip_Palestine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="30523059" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30523059/Cytogenetic_biomonitoring_on_a_group_of_petroleum_refinery_workers">Cytogenetic biomonitoring on a group of petroleum refinery workers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57946937" href="https://independent.academia.edu/giovannatranfo">giovanna tranfo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Environmental and Molecular Mutagenesis, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Workers employed in petroleum refineries are exposed to a wide range of toxic compounds (benzene, polycyclic aromatic hydrocarbons, heavy metals, etc.) with known mutagenic and carcinogenic potential. In this study, we investigated by using the cytokinesis block micronucleus (CBMN) assay on human peripheral blood lymphocytes (PBL) whether general occupational exposure in petroleum refineries resulted in early biological effects, which would be indicative of adverse health effects in the long term. In this study, out of more 500 workers enrolled in the study, 79 male subjects (46 nonsmokers and 33 smokers), employed in two different Italian petroleum refineries, and a total of 50 male control subjects (34 nonsmokers and 16 smokers) were selected by using very strict selection criteria. The comparison of chromosome damage in PBL between exposed and control populations pointed out a significant increase of micronuclei in the exposed group, correlated with the length of employment. Results confirm that smoking is the principal confounding factor for the responses. In conclusion, our results are indicative of a potential genotoxic risk related to the complex occupational exposure in petroleum refineries, despite the measures adopted in the plants, and corroborate the need to increase safety measures to avoid exposure to chemical agents. Environ. Mol. Mutagen. 52:440-447, 2011. V V C 2011 Wiley-Liss, Inc.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytogenetic biomonitoring on a group of petroleum refinery workers","attachmentId":50967593,"attachmentType":"pdf","work_url":"https://www.academia.edu/30523059/Cytogenetic_biomonitoring_on_a_group_of_petroleum_refinery_workers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30523059/Cytogenetic_biomonitoring_on_a_group_of_petroleum_refinery_workers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="83742375" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83742375/Monitoring_of_gas_station_attendants_exposure_to_benzene_toluene_xylene_BTX_using_three_color_chromosome_painting">Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63159410" href="https://independent.academia.edu/LucianoScherrer">Luciano Scherrer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular Cytogenetics, 2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Chronic exposure of BTX (benzene, toluene, xylene) may lead to progressive degeneration of bone marrow, aplastic anemia and/or leukemia. In Brazil there is no self-service fuel in gas stations and attendants fill the fuel themselves. Due to this they are chronically exposed to high concentration of BTX. Occupational exposure to benzene has been associated with increased chromosomal aberrations in peripheral blood lymphocytes. Fluorescence in situ hybridization (FISH) using whole chromosome painting (wcp) probes allows the rapid detection of chromosomal aberration. In the present study three-color wcp probes for chromosomes 1, 2 and 4 were used for monitoring 60 gas station attendants. Results: Blood tests were done and interviews were conducted for each worker. For searching for possible associations between the clinical characteristics and the frequency of chromosomal aberrations the workers were divided into two groups (≤ 10 chromosomal abnormalities per 1,000 metaphases and > 10 chromosomal abnormalities per 1,000 metaphases).The studied workers had a low median age (36 year), albeit long period of BTX exposure (median was 16 years). Low prevalence of smoking and moderate consumption of alcoholic beverages were found in this population. The cytogenetic analysis showed 16.6% (10/60) of workers with a high frequency of chromosomal abnormalities (>10 chromosomal abnormalities per 1,000 metaphases). Translocations were the most frequently observed chromosome aberration. The statistical analysis revealed highly significant differences in skin color (p = 0.002) and a weak significant differences in gender (p = 0.052) distribution between the two groups. Conclusion: 16.6% of the studied population showed elevated frequencies of chromosomal abnormalities, which is highly likely to be correlated with their exposure to BTX during their work. Therefore, further studies are needed for better characterize the work associated damage of the genome in gas station workers. It is necessary to better understand the risks that these workers are exposed, so that we can be effective in preventing diseases and maintaining the health of these workers and possibly the offspring.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting","attachmentId":88988506,"attachmentType":"pdf","work_url":"https://www.academia.edu/83742375/Monitoring_of_gas_station_attendants_exposure_to_benzene_toluene_xylene_BTX_using_three_color_chromosome_painting","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83742375/Monitoring_of_gas_station_attendants_exposure_to_benzene_toluene_xylene_BTX_using_three_color_chromosome_painting"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="88868219" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/88868219/Aplastic_anemia_clinical_implications_and_DNA_damage_in_workers_with_occupational_exposure_to_aromatic_hydrocarbons_in_Rio_de_Janeiro">Aplastic anemia, clinical implications and DNA damage in workers with occupational exposure to aromatic hydrocarbons in Rio de Janeiro</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63159410" href="https://independent.academia.edu/LucianoScherrer">Luciano Scherrer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">RESEARCH RESULTS IN BIOMEDICINE</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Brazilian gas station workers (GWS) are daily exposed to petroleumderived hydrocarbons which are harmful. The aim of the study: The aim of this study was to evaluate the clinical complaints and the genotoxic effects in GWS. Materials and methods: Overall, 88 workers were recruited versus 127 controls. To test the influence of the time of exposure, we have divided the workers into two groups arbitrarily in: Group 1 (G1), with the short time of exposure, ≤ 3 years; and Group 2 (G2), with the longer time of exposure, > 3 years. Results: The most relevant complaints were headache (32%) and fatigue (20%), lipothymia (11%), and less commonly sleeplessness and crustiness (both 5%), drowsiness (4%), irritability (3%) and pruritus (1%). 12% of them reported having alcoholic histories. The workers presented concerning alterations found in the blood. Polycythemia (5/88), leukocytosis (10/88) and anemia (19/88) were the most frequent. Hepatic enzymatic damage showed an increase in LDH, bilirubin and AST. Anemia was not associated with the higher LDH rate. Micronucleus (MN) and comet tests were determined in erythrocytes and leukocytes, respectively. The MN test was significant for the total workers group (P = 0.034). As for the class of the comet tails, they were significantly higher for G1 (P = 0.001) and for the total of workers (P = 0.001), for the G2 the significance was borderline (P = 0.05). Conclusion: There were important clinical and laboratorial complaints. Genotoxicity assays indicated DNA damage and they can be useful to prevent serious diseases in this group.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Aplastic anemia, clinical implications and DNA damage in workers with occupational exposure to aromatic hydrocarbons in Rio de Janeiro","attachmentId":92772468,"attachmentType":"pdf","work_url":"https://www.academia.edu/88868219/Aplastic_anemia_clinical_implications_and_DNA_damage_in_workers_with_occupational_exposure_to_aromatic_hydrocarbons_in_Rio_de_Janeiro","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/88868219/Aplastic_anemia_clinical_implications_and_DNA_damage_in_workers_with_occupational_exposure_to_aromatic_hydrocarbons_in_Rio_de_Janeiro"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="1545014" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure">11.Chromosomal Damage Risk Assessment to Benzene Exposure</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1020414" href="https://independent.academia.edu/AlexanderDecker">Alexander Decker</a></div><p class="ds-related-work--abstract ds2-5-body-sm">This study was a cross-sectional survey study to assess relative risk (RR) of chromosomal damage through benzene exposure in 45 gasoline stations workers compared to 30 controls in central area of Bangkok. Sister chromatid exchange (SCE) is as genotoxic biomarker, performed in white blood cells, and blood benzene level (BBL) is a biological marker of benzene exposure was performed by gas chromatographyflame ionization detector (GC-FID) using modified headspace solid-phase micro-extraction (HS-SPME) technique. The results showed that the average blood benzene level of these workers was significantly higher than in the controls (p < 0.001) as well as the frequency of sister chromatid exchange. The sister chromatid exchange was strongly and positively associated with blood benzene level of gasoline workers (p < 0.001) with the chromosomal damage relative risk at 2.50 (p < 0.001).</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"11.Chromosomal Damage Risk Assessment to Benzene Exposure","attachmentId":13096431,"attachmentType":"pdf","work_url":"https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/1545014/11_Chromosomal_Damage_Risk_Assessment_to_Benzene_Exposure"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="24509657" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24509657/Occupational_exposure_to_polycyclic_aromatic_hydrocarbons_and_DNA_damage_by_industry_a_nationwide_study_in_Germany">Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47240901" href="https://independent.academia.edu/EleonoraFabianova">Eleonora Fabianova</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Toxicology, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Exposure to polycyclic aromatic hydrocarbons (PAH) and DNA damage were analyzed in coke oven (n = 37), refractory (n = 96), graphite electrode (n = 26), and converter workers (n = 12), whereas construction workers (n = 48) served as referents. PAH exposure was assessed by personal air sampling during shift and biological monitoring in urine post shift (1-hydroxypyrene, 1-OHP and 1-, 2 + 9-, 3-, 4-hydroxyphenanthrenes, OHPHE). DNA damage was measured by 8-oxo-7,8-dihydro-2Јdeoxyguanosine (8-oxodGuo) and DNA strand breaks in blood post shift. Median 1-OHP and OHPHE were highest in converter workers (13.5 and 37.2 g/g crea). The industrial setting contributed to the metabolite concentrations rather than the air-borne concentration alone. Other routes of uptake, probably dermal, inXuenced associations between air-borne concentrations and levels of PAH metabolites in urine making biomonitoring results preferred parameters to assess exposure to PAH. DNA damage in terms of 8-oxo-dGuo and DNA strand breaks was higher in exposed workers compared to referents ranking highest for graphite-electrode production. The type of industry contributed to genotoxic DNA damage and DNA damage was not unequivocally associated to PAH on the individual level most likely due to potential contributions of co-exposures.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Occupational exposure to polycyclic aromatic hydrocarbons and DNA damage by industry: a nationwide study in Germany","attachmentId":44842438,"attachmentType":"pdf","work_url":"https://www.academia.edu/24509657/Occupational_exposure_to_polycyclic_aromatic_hydrocarbons_and_DNA_damage_by_industry_a_nationwide_study_in_Germany","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24509657/Occupational_exposure_to_polycyclic_aromatic_hydrocarbons_and_DNA_damage_by_industry_a_nationwide_study_in_Germany"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":73215195,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":73215195,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_73215195" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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