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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-8CT98BPDP3"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-8CT98BPDP3", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Dr. Victor Ling Laboratory works to understand the mechanism of resistance to anticancer drugs observed in many human cancers. Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P-glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity. In some cancers the correlation between the presence of Pgp function and non-response to chemotherapy has been established and the use of agents that block Pgp function has begun to yield promising results in combination with conventional chemotherapy." /> <link rel="canonical" href="https://www.bccrc.ca/dept/io/labs/ling-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/io/sites/integrativeoncology/files/BCClogo_Research_IntegrativeOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/io/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Ling Lab | Integrative Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/io/sites/integrativeoncology/files/css/css_SCagdG5Pz5nFXqskH7yDJ_TuZXsLPcezDhINFhqnSnQ.css?delta=0&language=en&theme=bccrc&include=eJxLSk4uStZPz8lPSszRLS6pzMnMS9cpriwuSc3VT0osTgUAzBAMcA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/io/sites/integrativeoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxLSk4uStZPz8lPSszRLS6pzMnMS9cpriwuSc3VT0osTgUAzBAMcA" /> </head> <body class="colour--emerald not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/io/">Integrative Oncology</a> </li> <li> Ling Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Ling Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/io/dept/io/people/victor-ling" class="button"><span>Dr. Victor Ling, PhD</span> </a> <div class="field field--field_phone_number"><a href="tel:604-675-8222">604-675-8222</a></div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>Dr. Victor Ling Laboratory works to understand the mechanism of resistance to anticancer drugs observed in many human cancers. Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P-glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity. In some cancers the correlation between the presence of Pgp function and non-response to chemotherapy has been established and the use of agents that block Pgp function has begun to yield promising results in combination with conventional chemotherapy. Our research in understanding the structure and function of Pgp will provide the fundamental basis for the pharmaceutical industry to design better blockers of Pgp. We and others have also discovered that PgP is a member of a superfamily of related proteins called ABC transporters which may be represented by more than 50 members in the human genome. These transporters are found in all kingdoms of life and appear to be involved in many fundamental biological processes. An inventory of ABC Transporters is currently being generated and we are profiling their expression patterns in different drug-resistant cell lines and some cancers. We are also studying a related liver-specific gene discovered in our lab, the sister of P-glycoprotein (sPgp), and its function in bile formation and cholesterol homeostasis. The mutation of Spgp in humans can cause Progressive Familiar Intrahepatic Cholaestasis -a liver disease, which is often fatal , especially in children. Technologies/expertise in our laboratory include: quantitative RT-PCR, expression profiling, generation of knockout mice, phylogenetic analysis, serial analysis of gene expression (SAGE), Protein biochemistry, Fluorescence labelling, and Transport kinetics.</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/io/people/victor-ling" ><figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-10/Dr.%20Ling%202010%203.jpg?itok=rJAUd3RI" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/io/people/victor-ling" rel="bookmark">Dr. Victor Ling, PhD</a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Distinguished Scientist</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8222">604-675-8222</a></div> <a href= "https://www.bccrc.ca/dept/io/contact/192" class="more">Send message</a> <a href="/dept/io/people/victor-ling" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Lin Liu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/io/contact/155" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title"></h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Jonathan Sheps </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/io/contact/156" class="more">Send message</a> </div> </section> </article> </div></section> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. 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