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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F4835328%2FImmune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":49609185,"identifier":"Attachment_49609185","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":4835328,"created_at":"2013-10-20T18:58:23.074-07:00","from_world_paper_id":120249180,"updated_at":"2024-11-16T01:51:04.112-08:00","_data":{"grobid_abstract":"The objective of this study was to evaluate the immune response and reactagenicity of a communed hepatitis B, diphtheria, tetanus and whole-cell Bordetella pertussis (DTPw-HBV) vaccine administered to healthy infants at 2, 4 and 6 months of age. A total of 179 infants (6-12 weeks of age) received three doses of DTPw-HBV vaccine. Blood samples for antibody determinations were taken before vaccination, 2 months after the second dose and I month after the third dose. solicited and unsolicited symptoms were recorded by parents in a diary card. All vaccinees had protective levels of anti-HBs [geometric mean titre (GMT): 1526 mlU ml-'], anti-diphtheria and antitetanus antibodies, I month after the third dose. Ninety-two percent of the subjects exhibited a response to the B. pertussis component. Most (99.4%) solicited reactions occurred within the first 48 h and the majority were mild or moderate. The safety, immunogenicity of this tetruvalent vaccine was demonstrated when it was administered in infunts following the 0, 2, 4-month dosing schedule. Copyright 0 1997 Elsevier Science Ltd.","publication_date":"1997,,","publication_name":"Vaccine","grobid_abstract_attachment_id":"49609185"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [6263365]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":49609185,"attachmentType":"pdf"}"><img alt="First page of “Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/49609185/mini_magick20190131-27589-1vz3odb.png?1548925446" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="6263365" href="https://independent.academia.edu/AlbertoPerez7"><img alt="Profile image of Alberto Perez" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/6263365/2574513/2990496/s65_alberto.perez.jpg" />Alberto Perez</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1997, Vaccine</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">3 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 4835328; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The objective of this study was to evaluate the immune response and reactagenicity of a communed hepatitis B, diphtheria, tetanus and whole-cell Bordetella pertussis (DTPw-HBV) vaccine administered to healthy infants at 2, 4 and 6 months of age. A total of 179 infants (6-12 weeks of age) received three doses of DTPw-HBV vaccine. Blood samples for antibody determinations were taken before vaccination, 2 months after the second dose and I month after the third dose. solicited and unsolicited symptoms were recorded by parents in a diary card. All vaccinees had protective levels of anti-HBs [geometric mean titre (GMT): 1526 mlU ml-'], anti-diphtheria and antitetanus antibodies, I month after the third dose. Ninety-two percent of the subjects exhibited a response to the B. pertussis component. Most (99.4%) solicited reactions occurred within the first 48 h and the majority were mild or moderate. The safety, immunogenicity of this tetruvalent vaccine was demonstrated when it was administered in infunts following the 0, 2, 4-month dosing schedule. Copyright 0 1997 Elsevier Science Ltd.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":49609185,"attachmentType":"pdf","workUrl":"https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":49609185,"attachmentType":"pdf","workUrl":"https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Vandepapeliere</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1995</p><p class="ds-related-work--abstract ds2-5-body-sm">A vaccine combining hepatitis B with diphtheria, tetanus and whole-cell Bordetella pertussis (DTPwHBV) would facilitate the attainment of universal vaccination of infants against hepatitis B. A candidate vaccine was administered to 42 infants beginning at 7-15 weeks of age. Antibodies were measured from pre- and postvaccination blood samples. After three doses, at least 94.9% of the infants were protected against hepatitis B, diphtheria and tetanus. Responses to B. pertussis were considered adequate. No serious adverse events were reported. These results indicate that this candidate vaccine is safe and immunogenic when administered to infants according to a three-dose schedule, with doses 2 months apart.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of a combined tetravalent diphtheria, tetanus, whole-cell pertussis and hepatitis B candidate vaccine administered to healthy infants according to a three-dose vaccination schedule","attachmentId":43682292,"attachmentType":"pdf","work_url":"https://www.academia.edu/14975690/Evaluation_of_a_combined_tetravalent_diphtheria_tetanus_whole_cell_pertussis_and_hepatitis_B_candidate_vaccine_administered_to_healthy_infants_according_to_a_three_dose_vaccination_schedule","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14975690/Evaluation_of_a_combined_tetravalent_diphtheria_tetanus_whole_cell_pertussis_and_hepatitis_B_candidate_vaccine_administered_to_healthy_infants_according_to_a_three_dose_vaccination_schedule"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="83687820" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial">Immunogenicity of two diphtheria-tetanus-whole cell pertussis-hepatitis B vaccines in infants: A comparative trial</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="106494209" href="https://independent.academia.edu/drprajaktbarde">dr prajakt barde</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity of two diphtheria-tetanus-whole cell pertussis-hepatitis B vaccines in infants: A comparative trial","attachmentId":88950764,"attachmentType":"pdf","work_url":"https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/83687820/Immunogenicity_of_two_diphtheria_tetanus_whole_cell_pertussis_hepatitis_B_vaccines_in_infants_A_comparative_trial"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="11441050" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants">Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27850479" href="https://independent.academia.edu/JuanLopez251">Juan Lopez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">The aim of this single-blind, parallel trial was to assess whether the hepatitis B (HB) component of a DTPw-HB vaccine interferes with the immune response to the other three components when administered at 3, 5 and 7 months of age. One hundred and six infants were randomized to receive three doses of DTPw or DTPw-HB vaccines. Seroprotection (or seroresponse) rates and geometric mean titers (GMT) of antibodies were assessed 3–6 weeks after the third dose. Anti-diphtheria, anti-tetanus and anti-Bordetella pertussis antibodies were measured by ELISA and anti-HBs by radio-immunoassay. Local and general signs and symptoms were recorded for a 4-day follow-up period after each vaccination. After the full vaccination course all subjects in both groups had seroprotective titers (≥0.1 IU ml−1) against diphtheria and tetanus and seroresponded (titers ≥15 EL.U ml−1) to B. pertussis, and there was no significant difference between groups in relation to GMT. All subjects vaccinated with DTPw-HB had seroprotective levels (≥10 mIU ml−1) of anti-HBs antibodies after the third dose (GMT of 2318 mIU ml−1). Overall there were no significant differences between groups in relation to the incidence of local and general symptoms. These results show that the HB component did not interfere with the immune response to the other three components of the vaccine.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants","attachmentId":46706768,"attachmentType":"pdf","work_url":"https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="62049503" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules">Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31850906" href="https://unito.academia.edu/CarlaZotti">Carla Zotti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><p class="ds-related-work--abstract ds2-5-body-sm">The reactogenicity and immunogenic&y of a tetravalent diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HB) vaccine (SmithKline Beecham) were studied in 565 infants immunized according to one of two different schedules, at 2, 4 and 6 months of age (group A n = 208) or at 3, 5 and 11 months of age (group B n = 357). The incidences of local and general reactions within the first 8 days after vaccination were similar in the two groups of infants, the vast majority being mild in intensity and occurring within 2-3 days of vaccine administration. Severe local symptoms were rare: pain affer 0.6% of all doses, redness after 0.5% and 1.3%, and swelling qfter 0.3%) and 1.570, in group A and B, respectively. Only one infant in group A and one in group B had a temperature > 39.O"C. Both schedules proved satisfactory in obtaining high levels of antibodies against all antigens. The rates of serologic response against the different antigens reached 100% in both groups. Antibody titres against all vaccine components were elevated following both schedules, but after the third dose of vaccine geometric mean antibody titres (GMTs) against D toxoid, jilamentous haemaglutinin (FHA), pertactin (PRN) and hepatitis B (HB) were significantly higher in the 3, 5, I1 group than after the 2, 4, 6 schedule. Antibody titres measured at 7 months of age in the group immunized at 2, 4 and 6 months were higher than those reached at 6 months of age in infants immunized at 3, 5 and 11 months, but FHA and PRN were within the range of a DTPa vaccine with proven ejj'kacy. We conclude that DTPa-HB vaccine was safe, well tolerated and highly immunogenic. Both vaccination schedules (2, 4, 6 and 3, 5, 11) can be considered suitable for mass immunization programmes.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules","attachmentId":74917132,"attachmentType":"pdf","work_url":"https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62049503/Safety_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_vaccine_administered_according_to_two_different_primary_vaccination_schedules"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="26688399" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age">Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50682354" href="https://independent.academia.edu/MahmoodJedditehrani">Mahmood Jeddi-tehrani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age","attachmentId":46970339,"attachmentType":"pdf","work_url":"https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="14098306" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14098306/Long_term_pertussis_specific_immune_responses_to_a_combined_diphtheria_tetanus_tricomponent_acellular_pertussis_and_hepatitis_B_vaccine_in_pre_term_infants">Long-term pertussis-specific immune responses to a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine in pre-term infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33105872" href="https://unibo.academia.edu/GiacomoFaldella">Giacomo Faldella</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Immunoglobulin G (IgG) antibody titres against pertussis antigens, Bordetella pertussis-specific proliferation and cytokine production by peripheral blood mononuclear cells (PBMCs) were evaluated at the age of 5-6 years in 13 children who had been pre-term infants with a gestational age (GA) of ≤31 weeks, 10 who had been pre-term infants with a GA of 32-37 weeks, and 15 who had been term infants with a GA of 38-42 weeks. All of the infants had been immunised with a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine (DTaP-HBV) at 3, 5, and 11 months of post-natal age. Our results show that the long-term immune responses induced by primary pertussis vaccination in the pre-term infants (especially those with a GA of ≤31 weeks) were qualitatively and quantitatively lower than those observed in the term infants. In order to maintain an adequate pertussis-specific immune response, in term children a booster at 5-6 years of age may be suggested, whereas in pre-term an earlier booster should be useful.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Long-term pertussis-specific immune responses to a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine in pre-term infants","attachmentId":44606406,"attachmentType":"pdf","work_url":"https://www.academia.edu/14098306/Long_term_pertussis_specific_immune_responses_to_a_combined_diphtheria_tetanus_tricomponent_acellular_pertussis_and_hepatitis_B_vaccine_in_pre_term_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14098306/Long_term_pertussis_specific_immune_responses_to_a_combined_diphtheria_tetanus_tricomponent_acellular_pertussis_and_hepatitis_B_vaccine_in_pre_term_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="29154874" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course">Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="54905929" href="https://independent.academia.edu/ValterSundh">Valter Sundh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Immunogenicity and reactogenicity of primary vaccination with combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus (DTPa-HBV-IPV) vaccine when co-administered with Haemophilus influenzae (Hib) conjugate vaccine were assessed in 60 healthy infants. Infants received HBV vaccine at birth, then DTPa-HBV-IPV and Hib vaccines at age 1.5 months, 3.5 months and 6 months. Blood samples were collected before the first DTPa-HBV-IPV and Hib vaccine doses and 1 month after dose 3. Reactogenicity was assessed using diary cards. One month after primary vaccination, all infants were seroprotected/ seropositive against all vaccine antigens evaluated. The poliovirus antigen could not be evaluated. The vaccines were well tolerated. No case of fever > 39.0°C was reported. No serious adverse events were considered related to vaccination. Primary vaccination with DTPa-HBV-IPV and Hib vaccines was immunogenic and well tolerated. Combined vaccines, such as this pentavalent vaccine, minimize the number of injections and vaccination visits required to complete primary vaccination, and provide choice and flexibility for physicians and vaccine providers.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and Reactogenicity of Diphtheria—Tetanus—Acellular Pertussis—Hepatitis B—Inactivated Poliovirus and Haemophilus influenzae Type B Vaccines Administered Concomitantly to Infants as a Three-dose Primary Course","attachmentId":49599593,"attachmentType":"pdf","work_url":"https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/29154874/Immunogenicity_and_Reactogenicity_of_Diphtheria_Tetanus_Acellular_Pertussis_Hepatitis_B_Inactivated_Poliovirus_and_Haemophilus_influenzae_Type_B_Vaccines_Administered_Concomitantly_to_Infants_as_a_Three_dose_Primary_Course"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="2495889" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life">Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293675" href="https://ankara.academia.edu/BetulUlukol">Betul Ulukol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">This study was designed to assess the immunogenicity of a vaccine combining diphtheria and tetanus toxoids, acellular pertussis vaccine, and inactivated poliovirus vaccine reconstituting Haemophilus influenzae type b polysaccharide conjugated to tetanus protein (DTaP-IPV//PRP-T; Pasteur Mérieux Connaught, Lyon, France) administered simultaneously in association with hepatitis B vaccine (RECOMBIVAX ™ Merck, Sharp & Dohme, West Point, PA, USA) for the primary immunization of infants. The vaccines were administered at two, three and four months of age. One hundred and sixty-two healthy infants, aged 8–10 weeks, were enrolled in the study. Blood samples were taken before the first dose and 4 weeks after the third dose. The infants were observed for 15 minutes after vaccination for any immediate reaction. Adverse events requiring a medical consultation were recorded by the parents in a diary over the 7 days following vaccination. Four weeks after the third immunization, the percentages of infants fulfilling seroconversion criteria were 98.9% for pertussis toxin, 95.9% for filamentous haemagglutinin, 100.0% for tetanus, 100.0% for diphtheria, 99.3% for poliovirus type 1, 100.0% for both poliovirus types 2 and 3, 98.0% for Haemophilus influenzae type b, and 100% for hepatitis B surface antigen. No vaccine-related serious adverse event was reported. The simultaneous administration of DTaP-IPV//PRP-T and hepatitis B vaccines at two, three and four months of age yielded clinically satisfactory immune responses to all antigens compared with historical controls and gave a good safety profile.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life","attachmentId":50600022,"attachmentType":"pdf","work_url":"https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="12232174" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12232174/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_">Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw- …</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="30716972" href="https://unearte.academia.edu/JUANLOPEZ">JUAN LOPEZ</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">The aim of this single-blind, parallel trial was to assess whether the hepatitis B (HB) component of a DTPw-HB vaccine inter$eres with the immune response to the other three components when administered at 3, 5 and 7 months of age. One hundred and six infants were randomized to receive three doses of DTPw or DTPw-HB vaccines.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw- …","attachmentId":46291457,"attachmentType":"pdf","work_url":"https://www.academia.edu/12232174/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12232174/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="18549004" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age">Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="60261763" href="https://independent.academia.edu/JohnThipphawong">John Thipphawong</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38584614" href="https://nrc-ca.academia.edu/LuisBarreto">Luis Barreto</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1998</p><p class="ds-related-work--abstract ds2-5-body-sm">Safety, immunogenicity and lot consistency of five-component pertussis combination vaccine (CPDT-IPV//PRP-T) in infants were compared to that of whole cell pertussis combination vaccine (DPT-IPV//PRP-T), as were separate and combined injections of CPDT-IPV and PRP-T. No significant differences in adverse event rates were observed between lots of CPDT-IPV//PRP-T or between separate or combined injections of CPDT-IPV and PRP-T. Minor differences in antibody responses were observed between lots of component pertussis vaccine. Higher concentrations of diphtheria and tetanus antitoxins were induced by separate than by combined injection of CPDT-IPV and PRP-T, but no other differences in immunogenicity were observed. Adverse reactions were more than twice as frequent after whole cell than after component pertussis vaccines. Antibody responses to pertussis toxoid, filamentous hemagglutin and pertactin were significantly greater after component vaccines, while the response to type 3 poliovirus was higher after whole cell vaccine. No significant differences were observed for other vaccine components. CPDT-IPV//PRP-T was safe and immunogenic in infants. Antibody results were similar to those observed in a Swedish field trial that demonstrated CPDT to be 85% effective in preventing clinical pertussis.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and immunogenicity of a combined five-component pertussis-diphtheria-tetanus-inactivated poliomyelitis-Haemophilus b conjugate vaccine administered to infants at two, four and six months of age","attachmentId":42159872,"attachmentType":"pdf","work_url":"https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18549004/Safety_and_immunogenicity_of_a_combined_five_component_pertussis_diphtheria_tetanus_inactivated_poliomyelitis_Haemophilus_b_conjugate_vaccine_administered_to_infants_at_two_four_and_six_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":49609185,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":49609185,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49609185" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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